PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24952939-3 2014 Here, we show that mice with keratinocyte-restricted p65/RelA deficiency were resistant to 7, 12-dimethylbenz(a)anthracene (DMBA)-/12-O-tetra decanoylphorbol-13 acetate (TPA)-induced skin carcinogenesis. Tetradecanoylphorbol Acetate 170-173 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 24952939-3 2014 Here, we show that mice with keratinocyte-restricted p65/RelA deficiency were resistant to 7, 12-dimethylbenz(a)anthracene (DMBA)-/12-O-tetra decanoylphorbol-13 acetate (TPA)-induced skin carcinogenesis. Tetradecanoylphorbol Acetate 170-173 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 57-61 24952939-5 2014 In addition, lack of p65 strongly inhibited TPA-induced epidermal hyperplasia and skin inflammation by suppressing the expression of proinflammatory cytokines and chemokines by epidermal keratinocytes. Tetradecanoylphorbol Acetate 44-47 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 21-24 24952939-6 2014 Therefore, p65-dependent NF-kappaB signalling in keratinocytes promotes DMBA-/TPA-induced skin carcinogenesis by protecting keratinocytes from DNA damage-induced death and facilitating the establishment of a tumour-nurturing proinflammatory microenvironment. Tetradecanoylphorbol Acetate 78-81 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 11-14 24258363-3 2014 Pretreatment with MSE in mouse skin has led to the reduction of TPA-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunits as well as phosphorylation of IkappaBalpha and p65 subsequent reduction of IkappaBalpha degradation. Tetradecanoylphorbol Acetate 64-67 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 194-197 20218615-4 2010 Pretreatment with magnolol resulted in the reduction of TPA-induced nuclear translocation of the nuclear factor-kappaB (NFkappaB) subunit and DNA binding by blocking the phosphorylation of IkappaBalpha and p65 and subsequent degradation of IkappaBalpha. Tetradecanoylphorbol Acetate 56-59 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 206-209 23399806-9 2013 Further, TPA induced altered expression of NF-kappaB (p65) and COX-2 was also attenuated by GOH. Tetradecanoylphorbol Acetate 9-12 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 54-57 22842666-4 2012 Pterostilbene also reduced TPA-induced phosphorylation of IkappaBalpha and p65 and caused subsequent degradation of IkappaBalpha. Tetradecanoylphorbol Acetate 27-30 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 75-78 21480506-8 2011 Moreover, significant increases in the protein levels analyzed by ELISA of c-Jun, p65, and p53 were observed in the skin of DMBA/TPA treated mice, whereas mice treated with 2 and DMBA/TPA had a similar expression of these transcription factors than the control mice. Tetradecanoylphorbol Acetate 129-132 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 82-85 20336681-5 2010 6-Shogaol also reduced TPA-induced phosphorylation of IkappaBalpha and p65, and caused subsequent degradation of IkappaBalpha. Tetradecanoylphorbol Acetate 23-26 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 71-74 23429041-6 2013 DHA also remarkably reduced PMA-induced p65, C/EBPbeta, c-jun and CREB nuclear translocation. Tetradecanoylphorbol Acetate 28-31 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-43 17962218-4 2007 Pre-treatment with 5-OH-HxMF resulted in the reduction of TPA-induced nuclear translocation of nuclear factor-kappaB (NF-kappaB) subunit and DNA binding by blocking phosphorylation of inhibitor kappaB (IkappaB) alpha and p65 and subsequent degradation of IkappaBalpha. Tetradecanoylphorbol Acetate 58-61 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 221-224 20026373-2 2010 The topical application of these phenolics 15min prior to TPA resulted in a significant decrease in the NF-kappaB activation which was measured in terms of p65-DNA binding. Tetradecanoylphorbol Acetate 58-61 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 156-159 20026373-3 2010 Tannic acid was the most potent inhibitor of the TPA-stimulated p65-DNA binding, while chlorogenic acid was the least effective compound. Tetradecanoylphorbol Acetate 49-52 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 64-67 18425423-7 2008 Significant increase in the protein levels of c-jun, p65, and p53 by ELISA were observed in DMBA/TPA treated mice tumors whereas less expression was observed in LA and LAM treated tumors. Tetradecanoylphorbol Acetate 97-100 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 53-56 17372274-6 2007 Pre-treatment with humulone attenuated TPA-induced phosphorylation of p65 and nuclear translocation of NF-kappaB subunit proteins. Tetradecanoylphorbol Acetate 39-42 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 70-73 16474181-6 2006 Resveratrol blunted TPA-induced phosphorylation of p65 and its interaction with CBP/p300, rendering NF-kappaB transcriptionally inactive. Tetradecanoylphorbol Acetate 20-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 51-54 16614396-7 2006 CP at the same doses inhibited TPA-induced nuclear translocation of p65 and subsequent DNA binding of NF-kappaB at 1 h by blocking the degradation of IkappaBalpha in mouse skin. Tetradecanoylphorbol Acetate 31-34 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 68-71 7791759-7 1995 Upon stimulation of RelA-overexpressing thymocytes with phorbol 12-myristate 13-acetate and lectin (phytohemaglutinin), different kappa B-binding complexes, including RelA homodimers, were partially released from I kappa B alpha. Tetradecanoylphorbol Acetate 56-87 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 20-24 15735738-6 2005 Pretreatment with [6]-gingerol resulted in a decrease in both TPA-induced DNA binding and transcriptional activities of NF-kappaB through suppression of IkappaBalpha degradation and p65 nuclear translocation. Tetradecanoylphorbol Acetate 62-65 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 182-185 15735738-8 2005 In addition, [6]-gingerol inhibited TPA-stimulated interaction of phospho-p65-(Ser-536) with cAMP response element binding protein-binding protein, a transcriptional coactivator of NF-kappaB. Tetradecanoylphorbol Acetate 36-39 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-77 12844482-8 2003 Curcumin treatment attenuated TPA- stimulated NF-kappaB activation in mouse skin, which was associated with its blockade of degradation of the inhibitory protein IkappaBalpha and also of subsequent translocation of the p65 subunit to nucleus. Tetradecanoylphorbol Acetate 30-33 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 219-222 9120401-7 1997 Furthermore, both T and B cells lacking RelA showed marked reduction in proliferative responses to stimulation with Con A, anti-CD3, anti-CD3 + anti-CD28, LPS, anti-IgM, and PMA + calcium ionophore. Tetradecanoylphorbol Acetate 174-177 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 40-44 7791759-7 1995 Upon stimulation of RelA-overexpressing thymocytes with phorbol 12-myristate 13-acetate and lectin (phytohemaglutinin), different kappa B-binding complexes, including RelA homodimers, were partially released from I kappa B alpha. Tetradecanoylphorbol Acetate 56-87 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 167-171 8035813-3 1994 NF-kappa B p50/p65 is the major inducible nuclear complex after lipopolysaccharide or phorbol myristate acetate treatment of 70Z/3 cells. Tetradecanoylphorbol Acetate 86-111 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 15-18 8254739-6 1994 One sequence motif is shown to constitutively bind CREB- and Jun-related proteins in both keratinocytes and fibroblasts, whereas the other is a target for TPA-induced c-Rel/p65(NF-kappa B)-binding activity specifically in keratinocytes. Tetradecanoylphorbol Acetate 155-158 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 173-176 32554052-4 2020 Eomes promoted the interaction of RelA and NFATc2 with the Ifng promoter and five CNS, including CNS-22 and CNS + 30 upon stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM). Tetradecanoylphorbol Acetate 139-170 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 34-38 32554052-4 2020 Eomes promoted the interaction of RelA and NFATc2 with the Ifng promoter and five CNS, including CNS-22 and CNS + 30 upon stimulation with phorbol 12-myristate 13-acetate (PMA) and ionomycin (IM). Tetradecanoylphorbol Acetate 172-175 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 34-38 29555853-4 2018 Wild-type p65 or p65DeltaSE both rescue NF-kappaB-dependent gene expression in p65-deficient murine hippocampal neurons responding to diffuse (PMA/ionomycin) stimulation. Tetradecanoylphorbol Acetate 143-146 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 10-13 29555853-4 2018 Wild-type p65 or p65DeltaSE both rescue NF-kappaB-dependent gene expression in p65-deficient murine hippocampal neurons responding to diffuse (PMA/ionomycin) stimulation. Tetradecanoylphorbol Acetate 143-146 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 17-20 29555853-4 2018 Wild-type p65 or p65DeltaSE both rescue NF-kappaB-dependent gene expression in p65-deficient murine hippocampal neurons responding to diffuse (PMA/ionomycin) stimulation. Tetradecanoylphorbol Acetate 143-146 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 17-20 30288224-5 2018 Mechanistic investigations demonstrated that GA down-regulated the expressions of IkappaBalpha and p65 and blocked the phosphorylation of IkappaBalpha and p65 in TPA-induced mouse skin. Tetradecanoylphorbol Acetate 162-165 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 155-158