PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2625810-4 1989 LPS, PMA and zymosan suppressed Fn production but stimulated PGE2 production by AM from patients with IIP but indomethacin reversed the suppressive effect of LPS, PMA and zymosan on Fn production. Tetradecanoylphorbol Acetate 5-8 fibronectin 1 Homo sapiens 32-34 2625810-3 1989 We also tested the effect of lipopolysaccharide (LPS), phorbol 12-myristate 13-acetate (PMA), zymosan and albumin-anti albumin complex (alb-anti alb) on production of Fn and PGE2 from AM. Tetradecanoylphorbol Acetate 55-86 fibronectin 1 Homo sapiens 167-169 2625810-4 1989 LPS, PMA and zymosan suppressed Fn production but stimulated PGE2 production by AM from patients with IIP but indomethacin reversed the suppressive effect of LPS, PMA and zymosan on Fn production. Tetradecanoylphorbol Acetate 5-8 fibronectin 1 Homo sapiens 182-184 2625810-4 1989 LPS, PMA and zymosan suppressed Fn production but stimulated PGE2 production by AM from patients with IIP but indomethacin reversed the suppressive effect of LPS, PMA and zymosan on Fn production. Tetradecanoylphorbol Acetate 163-166 fibronectin 1 Homo sapiens 182-184 3052623-4 1988 When the HEL cells were induced to spread on fibronectin in the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA), the MoAbs reacted with the focal adhesion sites. Tetradecanoylphorbol Acetate 76-112 fibronectin 1 Homo sapiens 45-56 2561968-3 1989 TPA also stimulates growth on fibronectin and collagen similar to that observed on laminin under control conditions. Tetradecanoylphorbol Acetate 0-3 fibronectin 1 Homo sapiens 30-41 2526813-2 1989 Treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) led to reduced binding of K562 to immobilized fibronectin (FN), although treated cells expressed 10-fold more cell surface FNR than untreated cells. Tetradecanoylphorbol Acetate 15-51 fibronectin 1 Homo sapiens 104-115 2526813-2 1989 Treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) led to reduced binding of K562 to immobilized fibronectin (FN), although treated cells expressed 10-fold more cell surface FNR than untreated cells. Tetradecanoylphorbol Acetate 53-56 fibronectin 1 Homo sapiens 104-115 3052623-4 1988 When the HEL cells were induced to spread on fibronectin in the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA), the MoAbs reacted with the focal adhesion sites. Tetradecanoylphorbol Acetate 114-117 fibronectin 1 Homo sapiens 45-56 2971556-5 1988 Treatment of the cells with TPA enhanced the binding of beads coated with human plasma fibronectin to the cells, as observed after incubation for 6 h with the beads. Tetradecanoylphorbol Acetate 28-31 fibronectin 1 Homo sapiens 87-98 2455575-8 1988 Induction by TPA led to the expression of fibronectin and factor V, which were not detected on nontreated cells. Tetradecanoylphorbol Acetate 13-16 fibronectin 1 Homo sapiens 42-53 6236860-6 1984 The peak of Fn-ms binding occurred four to five days after the induction of differentiation with dimethylsulfoxide (DMSO), and two days after induction by PMA. Tetradecanoylphorbol Acetate 155-158 fibronectin 1 Homo sapiens 12-14 2949779-4 1987 We conclude that TPA does not interfere with the fibronectin receptor on substrate-attached fibroblasts, but may influence intracellular fibronectin before it is bound to the extracellular matrix. Tetradecanoylphorbol Acetate 17-20 fibronectin 1 Homo sapiens 137-148 3346564-4 1988 Neutrophils, from burn patients, stimulated with FMLP, phorbol myristate acetate, and calcium ionophore A23187 demonstrated a 51%, 37%, and 45% decrease, respectively, in release of immunoreactive fibronectin compared with control neutrophils. Tetradecanoylphorbol Acetate 55-80 fibronectin 1 Homo sapiens 197-208 3530763-1 1986 One of the early effects of the phorbol ester tumor promoter 12-0-tetradecanoylphorbol-13-acetate (TPA) on cultured normal fibroblasts is the release of fibronectin into the culture medium. Tetradecanoylphorbol Acetate 99-102 fibronectin 1 Homo sapiens 153-164 3530763-2 1986 Immunophotoelectron microscopy was used to follow the loss of fibronectin from the upper cell surface of normal human foreskin fibroblasts exposed to TPA. Tetradecanoylphorbol Acetate 150-153 fibronectin 1 Homo sapiens 62-73 3530763-5 1986 Ten to 30 min of exposure to 100 ng/ml TPA in culture medium results in a readily visible decrease in upper cell surface fibronectin. Tetradecanoylphorbol Acetate 39-42 fibronectin 1 Homo sapiens 121-132 3530763-6 1986 In these experiments, 60 min of exposure to TPA releases nearly all upper cell surface fibronectin, leaving only occasional short streaks of label. Tetradecanoylphorbol Acetate 44-47 fibronectin 1 Homo sapiens 87-98 3530763-8 1986 This immunophotoelectron study shows the distribution of fibronectin on fibroblasts at high resolution and demonstrates that the initial fibronectin release resulting from TPA exposure is at the expense of preexisting cell-surface fibronectin. Tetradecanoylphorbol Acetate 172-175 fibronectin 1 Homo sapiens 137-148 3530763-8 1986 This immunophotoelectron study shows the distribution of fibronectin on fibroblasts at high resolution and demonstrates that the initial fibronectin release resulting from TPA exposure is at the expense of preexisting cell-surface fibronectin. Tetradecanoylphorbol Acetate 172-175 fibronectin 1 Homo sapiens 137-148 3986959-1 1985 The purpose of the experiments reported here is to improve our understanding of the mechanism whereby tumour promoters (e.g., 12-O-tetradecanoylphorbol-13-acetate, TPA) stimulate increased release of fibronectin (FN) from human lung fibroblasts (HLF) in culture. Tetradecanoylphorbol Acetate 126-162 fibronectin 1 Homo sapiens 200-211 3986959-1 1985 The purpose of the experiments reported here is to improve our understanding of the mechanism whereby tumour promoters (e.g., 12-O-tetradecanoylphorbol-13-acetate, TPA) stimulate increased release of fibronectin (FN) from human lung fibroblasts (HLF) in culture. Tetradecanoylphorbol Acetate 126-162 fibronectin 1 Homo sapiens 213-215 3882157-7 1985 Prolonged incubation of cultured endothelial cells after a 1-h treatment with phorbol myristate acetate resulted in an increased secretion of von Willebrand protein into the conditioned medium; in contrast, accumulation of thrombospondin and fibronectin in endothelial cell-conditioned medium was decreased. Tetradecanoylphorbol Acetate 78-103 fibronectin 1 Homo sapiens 242-253 6188625-11 1983 Furthermore, immunoprecipitation of the culture supernatants from these cells has shown that TPA induces the synthesis and secretion of fibronectin. Tetradecanoylphorbol Acetate 93-96 fibronectin 1 Homo sapiens 136-147 6733848-0 1984 Kinetics of fibronectin release from fibroblasts in response to 12-O-tetradecanoylphorbol-13-acetate and retinoic acid. Tetradecanoylphorbol Acetate 64-100 fibronectin 1 Homo sapiens 12-23 6733848-1 1984 We have studied the effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and its in vivo and in vitro antagonist retinoic acid (RA) on the synthesis and release of a major extracellular glycoprotein, fibronectin (FN), in human lung fibroblasts (HLF). Tetradecanoylphorbol Acetate 50-86 fibronectin 1 Homo sapiens 220-231 6733848-2 1984 The studies reported here investigate the question of whether the increased amounts of FN released by TPA treatment are cell-surface derived or require de novo synthesis of FN. Tetradecanoylphorbol Acetate 102-105 fibronectin 1 Homo sapiens 87-89 6733848-4 1984 Addition of TPA rapidly enhanced this release of FN into the culture medium, as shown with enzyme-linked immunosorbent assay. Tetradecanoylphorbol Acetate 12-15 fibronectin 1 Homo sapiens 49-51 6733848-8 1984 Pre-existing (unlabeled) FN accumulated in the medium as a result of TPA treatment at a time when newly synthesized (labeled) FN was still intracellular. Tetradecanoylphorbol Acetate 69-72 fibronectin 1 Homo sapiens 25-27 6704428-10 1984 Fibronectin synthesis or secretion was not affected by ethylnitrosourea-induced transformation, but the production of fibronectin was enhanced in the transformed cultures treated with TPA. Tetradecanoylphorbol Acetate 184-187 fibronectin 1 Homo sapiens 118-129 6733848-10 1984 We conclude that phorbol ester action and RA counteraction on the release of FN takes place on a cell-surface target; that FN which is released into the medium by TPA is derived from pre-existing FN; that RA specifically antagonizes TPA action. Tetradecanoylphorbol Acetate 163-166 fibronectin 1 Homo sapiens 77-79 6733848-10 1984 We conclude that phorbol ester action and RA counteraction on the release of FN takes place on a cell-surface target; that FN which is released into the medium by TPA is derived from pre-existing FN; that RA specifically antagonizes TPA action. Tetradecanoylphorbol Acetate 163-166 fibronectin 1 Homo sapiens 123-125 6733848-10 1984 We conclude that phorbol ester action and RA counteraction on the release of FN takes place on a cell-surface target; that FN which is released into the medium by TPA is derived from pre-existing FN; that RA specifically antagonizes TPA action. Tetradecanoylphorbol Acetate 163-166 fibronectin 1 Homo sapiens 123-125 6733848-10 1984 We conclude that phorbol ester action and RA counteraction on the release of FN takes place on a cell-surface target; that FN which is released into the medium by TPA is derived from pre-existing FN; that RA specifically antagonizes TPA action. Tetradecanoylphorbol Acetate 233-236 fibronectin 1 Homo sapiens 77-79 6733848-11 1984 No protein synthesis is required to release FN, to mediate enhanced FN release by TPA, or to counteract the enhanced release by RA. Tetradecanoylphorbol Acetate 82-85 fibronectin 1 Homo sapiens 68-70 16446495-5 2006 Moreover, our findings showed a decrease in tumor necrosis factor (TNF-alpha)- or phorbol 12-myristate 13-acetate (PMA)-induced O2*- production in CD patient neutrophils adherent to fibronectin as compared with controls. Tetradecanoylphorbol Acetate 82-113 fibronectin 1 Homo sapiens 182-193 28765903-6 2017 Our results showed that basal FN expression was increased by TPA treatment in a time-dependent manner. Tetradecanoylphorbol Acetate 61-64 fibronectin 1 Homo sapiens 30-32 28765903-9 2017 Furthermore, the alterations in FN and p53 expression in response to TPA were prevented by a specific MEK inhibitor, UO126. Tetradecanoylphorbol Acetate 69-72 fibronectin 1 Homo sapiens 32-34 28765903-11 2017 TPA-induced FN expression was decreased by the proteasome inhibitor MG132. Tetradecanoylphorbol Acetate 0-3 fibronectin 1 Homo sapiens 12-14 24335179-0 2013 Berberine suppresses TPA-induced fibronectin expression through the inhibition of VEGF secretion in breast cancer cells. Tetradecanoylphorbol Acetate 21-24 fibronectin 1 Homo sapiens 33-44 24335179-7 2013 RESULTS: Our results showed that TPA, a tumor promoter, significantly increased the level of VEGF and FN expression in both MCF7 and T47D breast cancer cells. Tetradecanoylphorbol Acetate 33-36 fibronectin 1 Homo sapiens 102-104 24335179-8 2013 On the other hand, TPA-induced VEGF and FN expression was suppressed by LY294002, a PI-3K inhibitor. Tetradecanoylphorbol Acetate 19-22 fibronectin 1 Homo sapiens 40-42 24335179-10 2013 We also found that TPA-induced VEGF and FN expression was decreased by BBR treatment. Tetradecanoylphorbol Acetate 19-22 fibronectin 1 Homo sapiens 40-42 24335179-12 2013 CONCLUSION: Taken together, we suggest that BBR may suppress TPA-induced VEGF and FN as well as VEGF-induced FN through the inhibition of the PI-3K/AKT pathway in breast cancer cells. Tetradecanoylphorbol Acetate 61-64 fibronectin 1 Homo sapiens 82-84 19160003-0 2009 Fibronectin promotes the phorbol 12-myristate 13-acetate-induced macrophage differentiation in myeloid leukemia cells. Tetradecanoylphorbol Acetate 25-56 fibronectin 1 Homo sapiens 0-11 17922475-6 2008 RESULTS: Both phorbol 12-myristate 13-acetate (PMA) [a protein kinase C (PKC) activator] and rosiglitazone increased TGFbeta expression and fibronectin and laminin release in C and T2D patients. Tetradecanoylphorbol Acetate 14-45 fibronectin 1 Homo sapiens 140-151 17922475-6 2008 RESULTS: Both phorbol 12-myristate 13-acetate (PMA) [a protein kinase C (PKC) activator] and rosiglitazone increased TGFbeta expression and fibronectin and laminin release in C and T2D patients. Tetradecanoylphorbol Acetate 47-50 fibronectin 1 Homo sapiens 140-151 28351321-6 2017 We demonstrate that temsirolimus and torin 1 effectively reduced the constitutive as well as phorbol-myristate-acetate/oncostatin-M-induced expression of mesenchymal markers (fibronectin, vimentin, and YKL40) and neural stem cell markers (Sox2, Oct4, nestin, and mushashi1). Tetradecanoylphorbol Acetate 93-118 fibronectin 1 Homo sapiens 175-186 25469314-1 2014 We present a detailed characterization of fibronectin (FN) adsorption and cell adhesion on poly(ethyl acrylate) (PEA) and poly(methyl acrylate) (PMA), two polymers with very similar physicochemical properties and chemical structure, which differ in one single methyl group in the lateral chain of the polymer. Tetradecanoylphorbol Acetate 145-148 fibronectin 1 Homo sapiens 42-53 23929882-4 2013 Phorbol 12-myristate 13-acetate (PMA), but not adenosine diphosphate (ADP), induced binding of FN to platelets in suspension. Tetradecanoylphorbol Acetate 0-31 fibronectin 1 Homo sapiens 95-97 23929882-4 2013 Phorbol 12-myristate 13-acetate (PMA), but not adenosine diphosphate (ADP), induced binding of FN to platelets in suspension. Tetradecanoylphorbol Acetate 33-36 fibronectin 1 Homo sapiens 95-97 23156739-7 2012 AGE-HSA up-regulated the expression of FN mRAN and protein in dose- and time-dependently (P < 0.01); PKC activator phorbol 12-myristate 13-acetate (PMA) induced FN expression, respectively depletion of PKC and calphostin C, a PKC inhibitor, effectively prevented both PMA and AGE-HSA-induced expression of the FN (P < 0.05). Tetradecanoylphorbol Acetate 118-149 fibronectin 1 Homo sapiens 39-41 23156739-7 2012 AGE-HSA up-regulated the expression of FN mRAN and protein in dose- and time-dependently (P < 0.01); PKC activator phorbol 12-myristate 13-acetate (PMA) induced FN expression, respectively depletion of PKC and calphostin C, a PKC inhibitor, effectively prevented both PMA and AGE-HSA-induced expression of the FN (P < 0.05). Tetradecanoylphorbol Acetate 118-149 fibronectin 1 Homo sapiens 164-166 23156739-7 2012 AGE-HSA up-regulated the expression of FN mRAN and protein in dose- and time-dependently (P < 0.01); PKC activator phorbol 12-myristate 13-acetate (PMA) induced FN expression, respectively depletion of PKC and calphostin C, a PKC inhibitor, effectively prevented both PMA and AGE-HSA-induced expression of the FN (P < 0.05). Tetradecanoylphorbol Acetate 118-149 fibronectin 1 Homo sapiens 164-166 16446495-5 2006 Moreover, our findings showed a decrease in tumor necrosis factor (TNF-alpha)- or phorbol 12-myristate 13-acetate (PMA)-induced O2*- production in CD patient neutrophils adherent to fibronectin as compared with controls. Tetradecanoylphorbol Acetate 115-118 fibronectin 1 Homo sapiens 182-193 15086456-5 2004 METHODS: The role of ROS in high glucose- and PKC-induced fibronectin expression was examined by quantification of cellular ROS after stimulation with high glucose and phorbol 12-myristate 13-acetate (PMA), by the effect of hydrogen peroxide (H(2)O(2)) and PMA on fibronectin expression, and finally by inhibition of ROS and PKC. Tetradecanoylphorbol Acetate 168-199 fibronectin 1 Homo sapiens 58-69 15086456-5 2004 METHODS: The role of ROS in high glucose- and PKC-induced fibronectin expression was examined by quantification of cellular ROS after stimulation with high glucose and phorbol 12-myristate 13-acetate (PMA), by the effect of hydrogen peroxide (H(2)O(2)) and PMA on fibronectin expression, and finally by inhibition of ROS and PKC. Tetradecanoylphorbol Acetate 201-204 fibronectin 1 Homo sapiens 58-69 12960735-6 2003 For the inhibition of basic fibroblast growth factor (bFGF)-, vascular endothelial growth factor (VEGF)- or beta-phorbol 12-myristate-13-acetate (PMA)-induced endothelial cell proliferation or endothelial cell adhesion to fibronectin, TMZ concentrations of at least 25 microM were necessary, indicating that bFGF-, VEGF- or protein kinase C-mediated pathways may not primarily be involved in the observed antiangiogenic effect. Tetradecanoylphorbol Acetate 146-149 fibronectin 1 Homo sapiens 222-233 11168928-13 2001 PKC activator phorbol 12-myristate 13-acetate (PMA) induced 2.2- and 1.4-fold increase in TGF-beta 1 and FN mRNA expression, respectively. Tetradecanoylphorbol Acetate 14-45 fibronectin 1 Homo sapiens 105-107 11873244-8 2002 Another agent known for stimulating the protein kinase C pathway, phorbol 12-myristate 13-acetate (10(-8) mol/L), had a similar effect, stimulating chemotaxis to fibronectin (146.2% +/- 8.6%). Tetradecanoylphorbol Acetate 66-97 fibronectin 1 Homo sapiens 162-173 11896934-1 2002 The aim of this study was to investigate whether neutrophil adhesion to extracellular matrix proteins like fibronectin, fibrinogen, and albumin influence the release proteins from primary and secondary granules of neutrophils stimulated by phorbol-myristate-acetate (PMA) and formyl-methionyl-leucyl-phenylalanine (f-MLP). Tetradecanoylphorbol Acetate 240-265 fibronectin 1 Homo sapiens 107-118 11896934-1 2002 The aim of this study was to investigate whether neutrophil adhesion to extracellular matrix proteins like fibronectin, fibrinogen, and albumin influence the release proteins from primary and secondary granules of neutrophils stimulated by phorbol-myristate-acetate (PMA) and formyl-methionyl-leucyl-phenylalanine (f-MLP). Tetradecanoylphorbol Acetate 267-270 fibronectin 1 Homo sapiens 107-118 11746831-4 2001 By using this vector and specific neutralizing monoclonal antibodies (mAbs), it was established that PMA-induced apoptosis also called for an interaction between cell-surface alpha(5)beta(1)-integrin and its deposited ligand fibronectin (FN), which is downstream of PKC-beta activation. Tetradecanoylphorbol Acetate 101-104 fibronectin 1 Homo sapiens 225-236 11746831-4 2001 By using this vector and specific neutralizing monoclonal antibodies (mAbs), it was established that PMA-induced apoptosis also called for an interaction between cell-surface alpha(5)beta(1)-integrin and its deposited ligand fibronectin (FN), which is downstream of PKC-beta activation. Tetradecanoylphorbol Acetate 101-104 fibronectin 1 Homo sapiens 238-240 11168928-13 2001 PKC activator phorbol 12-myristate 13-acetate (PMA) induced 2.2- and 1.4-fold increase in TGF-beta 1 and FN mRNA expression, respectively. Tetradecanoylphorbol Acetate 47-50 fibronectin 1 Homo sapiens 105-107 11168928-14 2001 Depletion of PKC and calphostin C, a PKC inhibitor, effectively prevented both PMA and high glucose-induced, but not constitutive, expression of TGF-beta 1 and FN. Tetradecanoylphorbol Acetate 79-82 fibronectin 1 Homo sapiens 160-162 10649441-0 2000 Transcriptional regulation of fibronectin gene by phorbol myristate acetate in hepatoma cells: a negative role for NF-kappaB. Tetradecanoylphorbol Acetate 50-75 fibronectin 1 Homo sapiens 30-41 11200811-3 2000 METHOD OF STUDY: Phytohemaglutinin (PHA) or phorbol myristate acetate (PMA) activated T cell adhesion to the following extracellular matrix proteins: collagen IV, fibronectin and elastin were studied in women with the history of RSA. Tetradecanoylphorbol Acetate 44-69 fibronectin 1 Homo sapiens 163-174 11200811-3 2000 METHOD OF STUDY: Phytohemaglutinin (PHA) or phorbol myristate acetate (PMA) activated T cell adhesion to the following extracellular matrix proteins: collagen IV, fibronectin and elastin were studied in women with the history of RSA. Tetradecanoylphorbol Acetate 71-74 fibronectin 1 Homo sapiens 163-174 10649441-1 2000 The transcriptional regulation of the fibronectin (FN) gene in hepatoma cells by phorbol myristate acetate (PMA) was investigated. Tetradecanoylphorbol Acetate 81-106 fibronectin 1 Homo sapiens 38-49 10649441-1 2000 The transcriptional regulation of the fibronectin (FN) gene in hepatoma cells by phorbol myristate acetate (PMA) was investigated. Tetradecanoylphorbol Acetate 81-106 fibronectin 1 Homo sapiens 51-53 10649441-1 2000 The transcriptional regulation of the fibronectin (FN) gene in hepatoma cells by phorbol myristate acetate (PMA) was investigated. Tetradecanoylphorbol Acetate 108-111 fibronectin 1 Homo sapiens 38-49 10649441-1 2000 The transcriptional regulation of the fibronectin (FN) gene in hepatoma cells by phorbol myristate acetate (PMA) was investigated. Tetradecanoylphorbol Acetate 108-111 fibronectin 1 Homo sapiens 51-53 10649441-4 2000 Deletion analysis revealed that the sequence between positions -69 and +136 of the FN gene was responsible for the PMA induction. Tetradecanoylphorbol Acetate 115-118 fibronectin 1 Homo sapiens 83-85 10399964-4 1999 Pericellular deposition of EDA-containing fibronectin (EDA+FN) was essential for TPA-induced cohort migration. Tetradecanoylphorbol Acetate 81-84 fibronectin 1 Homo sapiens 42-53 10221154-6 1999 The amount of AOS produced by the neutrophils adherent to fibronectin or polystyrene was maintained for one hour after stimulation with PMA, whereas that by suspended neutrophils gradually decreased with the time after stimulation. Tetradecanoylphorbol Acetate 136-139 fibronectin 1 Homo sapiens 58-69 9350346-2 1997 Phorbol myristate acetate (PMA), a PKC activator, stimulated fibronectin synthesis and its mRNA expression in both normal and transformed human lung fibroblasts (WI-38 and WI-38 VA13, respectively). Tetradecanoylphorbol Acetate 27-30 fibronectin 1 Homo sapiens 61-72 9894155-0 1998 Regulation of fibronectin gene expression by cyclic AMP and phorbol myristate acetate in HT-1080 human fibrosarcoma cells. Tetradecanoylphorbol Acetate 60-85 fibronectin 1 Homo sapiens 14-25 9894155-1 1998 We studied the regulation of fibronectin (FN) gene expression by cAMP and phorbol-12-myristate-13-acetate (PMA) in HT-1080 human fibrosarcoma cells. Tetradecanoylphorbol Acetate 74-105 fibronectin 1 Homo sapiens 29-40 9894155-1 1998 We studied the regulation of fibronectin (FN) gene expression by cAMP and phorbol-12-myristate-13-acetate (PMA) in HT-1080 human fibrosarcoma cells. Tetradecanoylphorbol Acetate 74-105 fibronectin 1 Homo sapiens 42-44 9894155-1 1998 We studied the regulation of fibronectin (FN) gene expression by cAMP and phorbol-12-myristate-13-acetate (PMA) in HT-1080 human fibrosarcoma cells. Tetradecanoylphorbol Acetate 107-110 fibronectin 1 Homo sapiens 29-40 9894155-1 1998 We studied the regulation of fibronectin (FN) gene expression by cAMP and phorbol-12-myristate-13-acetate (PMA) in HT-1080 human fibrosarcoma cells. Tetradecanoylphorbol Acetate 107-110 fibronectin 1 Homo sapiens 42-44 9437731-0 1998 Additional recognition sites in the C-terminal heparin-binding domain of fibronectin promote adhesion of PMA-treated U937 cells. Tetradecanoylphorbol Acetate 105-108 fibronectin 1 Homo sapiens 73-84 9437731-1 1998 Recently we have shown an evidence that a peptide, corresponding to residues Gln1892 to Gly1910, from the C-terminal heparin-binding domain of fibronectin promotes adhesion of phorbol-12-myristate 13-acetate (PMA)-treated U937 cells and binds to both integrin alpha 4 beta 1 and glycosaminoglycans on U937 cells surface. Tetradecanoylphorbol Acetate 176-207 fibronectin 1 Homo sapiens 143-154 9437731-1 1998 Recently we have shown an evidence that a peptide, corresponding to residues Gln1892 to Gly1910, from the C-terminal heparin-binding domain of fibronectin promotes adhesion of phorbol-12-myristate 13-acetate (PMA)-treated U937 cells and binds to both integrin alpha 4 beta 1 and glycosaminoglycans on U937 cells surface. Tetradecanoylphorbol Acetate 209-212 fibronectin 1 Homo sapiens 143-154 9437731-2 1998 We present additional adhesion-promoting sites to PMA-treated U937 cells present in the C-terminal heparin-binding domain of fibronectin. Tetradecanoylphorbol Acetate 50-53 fibronectin 1 Homo sapiens 125-136 9350346-2 1997 Phorbol myristate acetate (PMA), a PKC activator, stimulated fibronectin synthesis and its mRNA expression in both normal and transformed human lung fibroblasts (WI-38 and WI-38 VA13, respectively). Tetradecanoylphorbol Acetate 0-25 fibronectin 1 Homo sapiens 61-72 9769128-0 1998 TPA-induced cohort migration of well-differentiated human rectal adenocarcinoma cells: cells move in a RGD-dependent manner on fibronectin produced by cells, and phosphorylation of E-cadherin/catenin complex is induced independently of cell-extracellular matrix interactions. Tetradecanoylphorbol Acetate 0-3 fibronectin 1 Homo sapiens 127-138 9184073-6 1997 Kinetic studies indicated that fibronectin was rapidly secreted as an intact molecule and that proteolysis started within minutes and proceeded for at least 1 h. If cells were removed after 5 min TPA treatment, no further proteolysis of the secreted fibronectin was observed, indicating participation of cell-bound proteinases. Tetradecanoylphorbol Acetate 196-199 fibronectin 1 Homo sapiens 31-42 9192835-6 1997 Phorbol 12-myristate 13-acetate and 12(S)-hydroxyeicosatetraenoic acid, two activators of protein kinase C, stimulated adhesion of melanoma cells to immobilized fibronectin and PAC-1, a mAb to alphaIIb beta3. Tetradecanoylphorbol Acetate 0-31 fibronectin 1 Homo sapiens 161-172 9223226-7 1997 PMA caused a dose-related increase in EPBE adherence to fibronectin-coated plastic. Tetradecanoylphorbol Acetate 0-3 fibronectin 1 Homo sapiens 56-67 8616873-1 1996 Both TPA and A23187 dramatically enhanced MDA-MB-435 cell adhesion to type IV collagen (collagen IV), vitronectin, and, to some extent, fibronectin and laminin. Tetradecanoylphorbol Acetate 5-8 fibronectin 1 Homo sapiens 136-147 8866006-2 1996 Phorbol myristate acetate (PMA), a potent PKC activator, stimulated fibronectin synthesis in both normal and transformed fibroblasts in a time and dose dependent fashion. Tetradecanoylphorbol Acetate 0-25 fibronectin 1 Homo sapiens 68-79 8866006-2 1996 Phorbol myristate acetate (PMA), a potent PKC activator, stimulated fibronectin synthesis in both normal and transformed fibroblasts in a time and dose dependent fashion. Tetradecanoylphorbol Acetate 27-30 fibronectin 1 Homo sapiens 68-79 9067616-2 1997 HEL cells grow in suspension in culture medium, but attach and spread on fibronectin when treated with 10 nM phorbol myristate acetate. Tetradecanoylphorbol Acetate 109-134 fibronectin 1 Homo sapiens 73-84 9088892-7 1997 Induction of fibronectin expression was also obtained using the PKC-activating phorbolester Phorbol-12-myristat-13-acetat (PMA) which mimicks glucose-induced PKC activation. Tetradecanoylphorbol Acetate 123-126 fibronectin 1 Homo sapiens 13-24 8074477-0 1994 PMA induces shift from chondroitin to heparan sulphate on proteoglycans correlating with fibronectin adhesion of MDS human leukemia cells. Tetradecanoylphorbol Acetate 0-3 fibronectin 1 Homo sapiens 89-100 7925647-2 1994 Enhancement of cell adhesion to fibronectin was also observed on treatment of HL60 cells with 12-O-tetradecanoylphorbol 13-acetate (TPA). Tetradecanoylphorbol Acetate 94-130 fibronectin 1 Homo sapiens 32-43 7925647-2 1994 Enhancement of cell adhesion to fibronectin was also observed on treatment of HL60 cells with 12-O-tetradecanoylphorbol 13-acetate (TPA). Tetradecanoylphorbol Acetate 132-135 fibronectin 1 Homo sapiens 32-43 7925647-5 1994 Cell adhesion to fibronectin before and after treatment with BZ alpha GalNAc or TPA was inhibited by anti-VLA4 and anti-VLA5 monoclonal antibodies. Tetradecanoylphorbol Acetate 80-83 fibronectin 1 Homo sapiens 17-28 7523496-5 1994 Cross-linking of CD7 or CD16 molecules with primary and secondary Abs, as well as stimulation of NK cells with phorbol ester (PMA) or with calcium ionophore A23187 also induced beta 1 integrin-mediated adhesion of these cells to fibronectin (FN)-coated plastic surfaces. Tetradecanoylphorbol Acetate 126-129 fibronectin 1 Homo sapiens 229-240 7523496-5 1994 Cross-linking of CD7 or CD16 molecules with primary and secondary Abs, as well as stimulation of NK cells with phorbol ester (PMA) or with calcium ionophore A23187 also induced beta 1 integrin-mediated adhesion of these cells to fibronectin (FN)-coated plastic surfaces. Tetradecanoylphorbol Acetate 126-129 fibronectin 1 Homo sapiens 242-244 8027566-2 1994 Fibronectin, collagen type IV, and laminin promoted haptotactic and chemotactic migration of lymphoid T cell lines and 12-O-tetradecanoylphorbol 13-acetate-stimulated blood lymphocytes, as determined using a modified Boyden chamber system. Tetradecanoylphorbol Acetate 119-155 fibronectin 1 Homo sapiens 0-11 8287495-0 1994 12-O-tetradecanoylphorbol 13-acetate stimulates human T-lymphocyte adherence to the fibronectin RGD domain and the laminin IKVAV domain. Tetradecanoylphorbol Acetate 0-36 fibronectin 1 Homo sapiens 84-95 8112867-7 1994 TNF-alpha-induced adherence to fibronectin was suppressed from 69% +/- 5% of the phorbol myristate acetate response to 38% +/- 7% (P = 0.0154). Tetradecanoylphorbol Acetate 81-106 fibronectin 1 Homo sapiens 31-42 7506954-2 1994 We investigated the ability of phorbol myristate acetate (PMA) to stimulate the human promyelocytic cell line HL-60 to adhere to fibronectin, either in its undifferentiated state (HL60) or after dimethylsulfoxide-induced differentiation along the granulocytic pathway (dHL60). Tetradecanoylphorbol Acetate 31-56 fibronectin 1 Homo sapiens 129-140 7506954-2 1994 We investigated the ability of phorbol myristate acetate (PMA) to stimulate the human promyelocytic cell line HL-60 to adhere to fibronectin, either in its undifferentiated state (HL60) or after dimethylsulfoxide-induced differentiation along the granulocytic pathway (dHL60). Tetradecanoylphorbol Acetate 58-61 fibronectin 1 Homo sapiens 129-140 8287495-8 1994 These data demonstrate that TPA activates T-cell adherence to laminin and to fibronectin via specific sites on each protein and that this adhesion may be associated with integrin phosphorylation. Tetradecanoylphorbol Acetate 28-31 fibronectin 1 Homo sapiens 77-88 8262552-6 1993 TPA-activated U937 cells showed a two-fold increase in the expression of the RGD-dependent integrin receptors alpha 3 and alpha 5, and a reduction in the expression of alpha 4, another fibronectin-specific receptor, whereas the common beta 1 chain was unchanged. Tetradecanoylphorbol Acetate 0-3 fibronectin 1 Homo sapiens 185-196 7505022-1 1993 Three different agents, dithiothreitol (DTT), Mn2+, and phorbol ester (TPA), were found to induce HL-60 cell adhesion to fibronectin through distinct mechanisms. Tetradecanoylphorbol Acetate 71-74 fibronectin 1 Homo sapiens 121-132 7505022-7 1993 TPA-treated HL-60 cells adhere and spread on fibronectin substrates, whereas DTT- and Mn(2+)-treated cells adhere but do not spread. Tetradecanoylphorbol Acetate 0-3 fibronectin 1 Homo sapiens 45-56 1377951-3 1992 We concluded that sphingosine is a potent inhibitor of FN release from the cell surface, independent of its inhibition of PKC; and that TPA stimulates release of FN by a pathway other than activation of PKC. Tetradecanoylphorbol Acetate 136-139 fibronectin 1 Homo sapiens 162-164 1377951-7 1992 In conclusion, we have shown that: (1) sphingosine had a robust effect inhibiting the release of FN from fibroblasts, independent of its action on PKC; (2) TPA treatment of these cells resulted in inhibition of PKA; (3) inhibition of PKA stimulated FN release whereas its activation decreased this release. Tetradecanoylphorbol Acetate 156-159 fibronectin 1 Homo sapiens 97-99 1377951-1 1992 In testing the hypothesis that the stimulation of the release of fibronectin (FN) by 12-O-tetradecanoylphorbol 13-acetate (TPA) from human lung fibroblasts in culture is the result of activation of protein kinase C (PKC), we found that the PKC inhibitor sphingosine strongly inhibited FN release in presence and even in absence of TPA. Tetradecanoylphorbol Acetate 85-121 fibronectin 1 Homo sapiens 65-76 1377951-1 1992 In testing the hypothesis that the stimulation of the release of fibronectin (FN) by 12-O-tetradecanoylphorbol 13-acetate (TPA) from human lung fibroblasts in culture is the result of activation of protein kinase C (PKC), we found that the PKC inhibitor sphingosine strongly inhibited FN release in presence and even in absence of TPA. Tetradecanoylphorbol Acetate 85-121 fibronectin 1 Homo sapiens 78-80 1377951-7 1992 In conclusion, we have shown that: (1) sphingosine had a robust effect inhibiting the release of FN from fibroblasts, independent of its action on PKC; (2) TPA treatment of these cells resulted in inhibition of PKA; (3) inhibition of PKA stimulated FN release whereas its activation decreased this release. Tetradecanoylphorbol Acetate 156-159 fibronectin 1 Homo sapiens 249-251 1377951-1 1992 In testing the hypothesis that the stimulation of the release of fibronectin (FN) by 12-O-tetradecanoylphorbol 13-acetate (TPA) from human lung fibroblasts in culture is the result of activation of protein kinase C (PKC), we found that the PKC inhibitor sphingosine strongly inhibited FN release in presence and even in absence of TPA. Tetradecanoylphorbol Acetate 123-126 fibronectin 1 Homo sapiens 65-76 1377951-1 1992 In testing the hypothesis that the stimulation of the release of fibronectin (FN) by 12-O-tetradecanoylphorbol 13-acetate (TPA) from human lung fibroblasts in culture is the result of activation of protein kinase C (PKC), we found that the PKC inhibitor sphingosine strongly inhibited FN release in presence and even in absence of TPA. Tetradecanoylphorbol Acetate 123-126 fibronectin 1 Homo sapiens 78-80 1937565-4 1991 A large number of Fn fragments were revealed by Western immunoblotting of serum-free conditioned medium 4 hr after treatment of CPAE monolayers with PMA. Tetradecanoylphorbol Acetate 149-152 fibronectin 1 Homo sapiens 18-20 1377951-1 1992 In testing the hypothesis that the stimulation of the release of fibronectin (FN) by 12-O-tetradecanoylphorbol 13-acetate (TPA) from human lung fibroblasts in culture is the result of activation of protein kinase C (PKC), we found that the PKC inhibitor sphingosine strongly inhibited FN release in presence and even in absence of TPA. Tetradecanoylphorbol Acetate 331-334 fibronectin 1 Homo sapiens 78-80 1340504-4 1992 Exposure to Phorbol myristate acetate (PMA) dramatically increased binding of both U937 and HL-60 cells to Fn with plateau effects at 10 ng/ml for both cell lines and at 30 and 60 minutes for U937 and HL-60, respectively. Tetradecanoylphorbol Acetate 12-37 fibronectin 1 Homo sapiens 107-109 1340504-4 1992 Exposure to Phorbol myristate acetate (PMA) dramatically increased binding of both U937 and HL-60 cells to Fn with plateau effects at 10 ng/ml for both cell lines and at 30 and 60 minutes for U937 and HL-60, respectively. Tetradecanoylphorbol Acetate 39-42 fibronectin 1 Homo sapiens 107-109 1934258-1 1991 Previous work from our laboratory showed that tumor promoters such as phorbol ester (TPA) stimulated the release of fibronectin (FN) from the surface of several cell types in culture, and that this stimulation was counteracted by retinoic acid. Tetradecanoylphorbol Acetate 85-88 fibronectin 1 Homo sapiens 116-127 1934258-1 1991 Previous work from our laboratory showed that tumor promoters such as phorbol ester (TPA) stimulated the release of fibronectin (FN) from the surface of several cell types in culture, and that this stimulation was counteracted by retinoic acid. Tetradecanoylphorbol Acetate 85-88 fibronectin 1 Homo sapiens 129-131 1959503-4 1991 In most experiments, fibronectin proteolysis was suppressed by smoke exposure--an effect that was reversible on treatment with phorbol myristate acetate. Tetradecanoylphorbol Acetate 127-152 fibronectin 1 Homo sapiens 21-32 1831204-6 1991 These alterations were not blocked by the protein kinase C inhibitor H-7, which did inhibit TPA-induced T cell attachment to fibronectin. Tetradecanoylphorbol Acetate 92-95 fibronectin 1 Homo sapiens 125-136 1845239-0 1991 Interaction of TPA-treated trichomonads with fibronectin-coated substrata. Tetradecanoylphorbol Acetate 15-18 fibronectin 1 Homo sapiens 45-56 2001408-12 1991 The treatment of neutrophils with antiserum against human plasma fibronectin inhibited the respiratory burst in response to formyl-methionyl-leucylphenylalanine (fMLP) and phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 172-203 fibronectin 1 Homo sapiens 65-76 2001408-12 1991 The treatment of neutrophils with antiserum against human plasma fibronectin inhibited the respiratory burst in response to formyl-methionyl-leucylphenylalanine (fMLP) and phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 205-208 fibronectin 1 Homo sapiens 65-76 2233705-10 1990 One hour treatment with the phorbol ester tumor promoter, 12-0-tetradecanoyl phorbol-13-acetate (TPA), stimulated a nine-fold increase in release of preexisting, dimeric cell-surface FN (125I-labeled). Tetradecanoylphorbol Acetate 97-100 fibronectin 1 Homo sapiens 183-185 2233705-11 1990 The major effect of longer term TPA treatment up to nine hours was continued depletion of dimeric cell-surface FN. Tetradecanoylphorbol Acetate 32-35 fibronectin 1 Homo sapiens 111-113 2233705-12 1990 Increased release of cell-surface multimeric FN was also stimulated by TPA, but to a much lesser extent. Tetradecanoylphorbol Acetate 71-74 fibronectin 1 Homo sapiens 45-47 2233705-13 1990 Release of newly synthesized (pulse-labeled) dimeric FN was also stimulated by TPA though much less than pre-existing FN, and TPA treatment produced a small decrease in the steady-state level of multimeric FN. Tetradecanoylphorbol Acetate 79-82 fibronectin 1 Homo sapiens 53-55 2233705-14 1990 Thus, preexisting cell-surface FN and newly synthesized FN differ dramatically in their susceptibility to TPA treatment. Tetradecanoylphorbol Acetate 106-109 fibronectin 1 Homo sapiens 31-33 2233705-14 1990 Thus, preexisting cell-surface FN and newly synthesized FN differ dramatically in their susceptibility to TPA treatment. Tetradecanoylphorbol Acetate 106-109 fibronectin 1 Homo sapiens 56-58 1692028-5 1990 Upon exposure to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), the amount of both vimentin and cytokeratin appeared to be greatly increased within 3 days and was found both in dispersed cytoplasmic fibrils, in large spherical, eccentric aggregates, as well as in cytoplasmic fibrils in cells spreading on fibronectin. Tetradecanoylphorbol Acetate 35-71 fibronectin 1 Homo sapiens 321-332 1692028-5 1990 Upon exposure to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), the amount of both vimentin and cytokeratin appeared to be greatly increased within 3 days and was found both in dispersed cytoplasmic fibrils, in large spherical, eccentric aggregates, as well as in cytoplasmic fibrils in cells spreading on fibronectin. Tetradecanoylphorbol Acetate 73-76 fibronectin 1 Homo sapiens 321-332 2327658-6 1990 Lipopolysaccharide, phorbol myristate acetate, and zymosan suppressed Fn release from AM but stimulated their PGE2 release, and these effects were reversed by indomethacin. Tetradecanoylphorbol Acetate 20-45 fibronectin 1 Homo sapiens 70-72 2188740-5 1990 Upon exposure to TPA the cells spread on a growth substratum covered with human plasma fibronectin (Fn). Tetradecanoylphorbol Acetate 17-20 fibronectin 1 Homo sapiens 87-98 34312810-5 2021 Phorbol 12-myristate 13-acetate and staurosporine, which induced cell adhesion to fibronectin surface and ERM dephosphorylation, caused a decrease in surface stiffness in KG-1 cells. Tetradecanoylphorbol Acetate 0-31 fibronectin 1 Homo sapiens 82-93 1969920-4 1990 In contrast, IB4 completely inhibited PMA-stimulated PMN adherence to gelatin, fibronectin, collagen IV, and endothelial cell monolayers. Tetradecanoylphorbol Acetate 38-41 fibronectin 1 Homo sapiens 79-90