PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8195229-2 1994 Here we show that the maximal hyperphosphorylation of Raf-1 and MAPKK (10 min) was substantially achieved after the maximal activation of MAPKKK of Raf-1, MAPKK (2-5 min), and MAPK in Chinese hamster ovary cells overexpressing human insulin receptor (CHO-HIR cells) treated with insulin or 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 290-326 insulin receptor Homo sapiens 233-249 7945263-1 1994 Phorbol 12-myristate 13-acetate (PMA)-stimulated phosphorylation of the human insulin receptor (IR) was characterized and compared in two cell types of different lineage: normal rat kidney epithelial (NRK) cells and Chinese hamster ovary (CHO) fibroblasts. Tetradecanoylphorbol Acetate 0-31 insulin receptor Homo sapiens 78-99 7945263-1 1994 Phorbol 12-myristate 13-acetate (PMA)-stimulated phosphorylation of the human insulin receptor (IR) was characterized and compared in two cell types of different lineage: normal rat kidney epithelial (NRK) cells and Chinese hamster ovary (CHO) fibroblasts. Tetradecanoylphorbol Acetate 33-36 insulin receptor Homo sapiens 78-99 7945263-4 1994 Tryptic phosphopeptide analysis by Tricine/SDS/PAGE revealed significant differences in the PMA-stimulated phosphorylation of the IR in these two cell types. Tetradecanoylphorbol Acetate 92-95 insulin receptor Homo sapiens 130-132 7945263-9 1994 These results demonstrate that PMA-stimulated phosphorylation of the IR can exhibit significant differences when expressed in different cell types, and that Ser1315 is a major PMA-stimulated phosphorylation site on the human IR. Tetradecanoylphorbol Acetate 31-34 insulin receptor Homo sapiens 69-71 7945263-9 1994 These results demonstrate that PMA-stimulated phosphorylation of the IR can exhibit significant differences when expressed in different cell types, and that Ser1315 is a major PMA-stimulated phosphorylation site on the human IR. Tetradecanoylphorbol Acetate 31-34 insulin receptor Homo sapiens 225-227 7945263-9 1994 These results demonstrate that PMA-stimulated phosphorylation of the IR can exhibit significant differences when expressed in different cell types, and that Ser1315 is a major PMA-stimulated phosphorylation site on the human IR. Tetradecanoylphorbol Acetate 176-179 insulin receptor Homo sapiens 225-227 8195229-2 1994 Here we show that the maximal hyperphosphorylation of Raf-1 and MAPKK (10 min) was substantially achieved after the maximal activation of MAPKKK of Raf-1, MAPKK (2-5 min), and MAPK in Chinese hamster ovary cells overexpressing human insulin receptor (CHO-HIR cells) treated with insulin or 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 328-331 insulin receptor Homo sapiens 233-249 7686158-6 1993 Insulin, guanosine 5"-O-(3-thiotriphosphate), guanylyl imidodiphosphate, NaF, and phorbol 12-myristate 13-acetate also induced the translocation of GLUT4myc in Chinese hamster ovary cells coexpressing the human insulin receptor. Tetradecanoylphorbol Acetate 82-113 insulin receptor Homo sapiens 211-227 8393875-1 1993 Phosphorylation of threonine 1336 of the human insulin receptor (HIR) is stimulated by insulin or 4 beta-phorbol 12-myristate 13-acetate in Chinese hamster ovary (CHO) transfectant cells expressing the wild type receptor (CHO/HIR). Tetradecanoylphorbol Acetate 98-136 insulin receptor Homo sapiens 47-63 1657981-6 1991 In conclusion, 1) TPA-induced inhibition of insulin receptor tyrosine autophosphorylation was linked to concomitant inhibition of the biological effects of insulin in cells expressing either wild-type or COOH-terminal truncated insulin receptors; and 2) the inhibitory effects of TPA were not dependent upon phosphorylation of COOH-terminal residues and furthermore appeared to be independent of phosphorylation of any insulin receptor serine/threonine residues. Tetradecanoylphorbol Acetate 280-283 insulin receptor Homo sapiens 44-60 3533683-11 1986 The ability of diacylglycerol to mimic the effects of TPA on the insulin receptor supports the concept of diacylglycerols as endogenous phorbol diester analogues even though the sole role of protein kinase C in our system is doubtful. Tetradecanoylphorbol Acetate 54-57 insulin receptor Homo sapiens 65-81 1657981-2 1991 TPA increased total phosphorylation of the wild-type insulin receptor and inhibited insulin-stimulated autophosphorylation by 32 +/- 10% in HIRc cells. Tetradecanoylphorbol Acetate 0-3 insulin receptor Homo sapiens 53-69 1657981-6 1991 In conclusion, 1) TPA-induced inhibition of insulin receptor tyrosine autophosphorylation was linked to concomitant inhibition of the biological effects of insulin in cells expressing either wild-type or COOH-terminal truncated insulin receptors; and 2) the inhibitory effects of TPA were not dependent upon phosphorylation of COOH-terminal residues and furthermore appeared to be independent of phosphorylation of any insulin receptor serine/threonine residues. Tetradecanoylphorbol Acetate 18-21 insulin receptor Homo sapiens 44-60 1657981-6 1991 In conclusion, 1) TPA-induced inhibition of insulin receptor tyrosine autophosphorylation was linked to concomitant inhibition of the biological effects of insulin in cells expressing either wild-type or COOH-terminal truncated insulin receptors; and 2) the inhibitory effects of TPA were not dependent upon phosphorylation of COOH-terminal residues and furthermore appeared to be independent of phosphorylation of any insulin receptor serine/threonine residues. Tetradecanoylphorbol Acetate 18-21 insulin receptor Homo sapiens 228-244 3255363-2 1988 Changes in insulin receptor number, affinity and mRNA levels were observed when HL60 cells were induced to differentiate with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or dimethylsulphoxide (DMSO). Tetradecanoylphorbol Acetate 126-163 insulin receptor Homo sapiens 11-27 3255363-2 1988 Changes in insulin receptor number, affinity and mRNA levels were observed when HL60 cells were induced to differentiate with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or dimethylsulphoxide (DMSO). Tetradecanoylphorbol Acetate 165-168 insulin receptor Homo sapiens 11-27 3255363-3 1988 Total and high-affinity insulin receptor numbers decreased following treatment of HL60 cells with DMSO, whereas total insulin receptor number increased and high-affinity receptor number decreased in cells treated with TPA. Tetradecanoylphorbol Acetate 218-221 insulin receptor Homo sapiens 118-134 3017998-6 1986 The insulin receptor was found to behave differently in response to phorbol myristate acetate, however, in that only the occupied receptors were stimulated to internalize. Tetradecanoylphorbol Acetate 68-93 insulin receptor Homo sapiens 4-20 6751097-8 1982 TPA perturbs the insulin receptor of cultured human lymphocytes in a fashion similar to its effect on the epidermal growth factor receptor of several other cell types. Tetradecanoylphorbol Acetate 0-3 insulin receptor Homo sapiens 17-33