PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9862447-6	1998	Long-term incubation (24 h) of mesangial cells with TPA, which downregulates PKC-alpha, -delta, and -epsilon isoenzymes, resulted in a recovery of IL-1beta-stimulated neutral SMase activity as well as ceramide formation.	Tetradecanoylphorbol Acetate	52-55	interleukin 1 beta	Rattus norvegicus	147-155	
11199339-1	2000	Production of interleukin (IL)-1 beta, IL-6 and tumor necrosis factor (TNF)-alpha by rat corneal epithelial cells in response to lipopolysaccharide and phorbol-12-myristate-13-acetate (PMA) was tested.	Tetradecanoylphorbol Acetate	152-183	interleukin 1 beta	Rattus norvegicus	14-37	
10571249-3	1999	We found that treatment of mesangial cells with the biologically active phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate inhibited IL-1beta induction of sPLA2-IIA mRNA, protein, and activity, whereas the inactive compound 4alpha-phorbol 12,13-didecanoate was without effect.	Tetradecanoylphorbol Acetate	72-103	interleukin 1 beta	Rattus norvegicus	149-157	
10571249-3	1999	We found that treatment of mesangial cells with the biologically active phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate inhibited IL-1beta induction of sPLA2-IIA mRNA, protein, and activity, whereas the inactive compound 4alpha-phorbol 12,13-didecanoate was without effect.	Tetradecanoylphorbol Acetate	105-108	interleukin 1 beta	Rattus norvegicus	149-157	
10571249-5	1999	Only after down-regulation of PKC-epsilon isoenzyme by 24-hr preincubation with PMA were we able to reconstitute the IL-1beta-induced sPLA2-IIA expression.	Tetradecanoylphorbol Acetate	80-83	interleukin 1 beta	Rattus norvegicus	117-125	
7722482-4	1995	This stimulatory action of phorbol 12-myristate 13-acetate was significantly reduced by staurosporine, by calphostin C and by the desensitization of protein kinase C. Interleukin 1 beta increased interleukin 6 release in a concentration-related manner.	Tetradecanoylphorbol Acetate	27-58	interleukin 1 beta	Rattus norvegicus	167-185	
7586373-10	1995	Phorbol 12-myristate 13-acetate (PMA) also augmented NO synthesis in IL-1 beta-stimulated but not in unstimulated cells in a dose-dependent manner.	Tetradecanoylphorbol Acetate	0-31	interleukin 1 beta	Rattus norvegicus	69-78	
7586373-10	1995	Phorbol 12-myristate 13-acetate (PMA) also augmented NO synthesis in IL-1 beta-stimulated but not in unstimulated cells in a dose-dependent manner.	Tetradecanoylphorbol Acetate	33-36	interleukin 1 beta	Rattus norvegicus	69-78	
8079811-4	1994	Peritoneal administration of IL-1 beta caused elicitation of cells which were enriched in eosinophils; however, the functional responses of the cells in all three groups were broadly similar in terms of the ability of the agonists FMLP, PMA and A23187 to initiate superoxide generation, beta-glucuronidase secretion and leukotriene generation.	Tetradecanoylphorbol Acetate	237-240	interleukin 1 beta	Rattus norvegicus	29-38	
7526844-3	1994	Here we report that addition of the biologically active phorbol esters, phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), dose-dependently inhibited the IL-1 beta-stimulated increase in iNOS mRNA levels and nitrite production.	Tetradecanoylphorbol Acetate	72-103	interleukin 1 beta	Rattus norvegicus	178-187	
7526844-3	1994	Here we report that addition of the biologically active phorbol esters, phorbol 12-myristate 13-acetate (PMA) and phorbol 12,13-dibutyrate (PDBu), dose-dependently inhibited the IL-1 beta-stimulated increase in iNOS mRNA levels and nitrite production.	Tetradecanoylphorbol Acetate	105-108	interleukin 1 beta	Rattus norvegicus	178-187	
8035171-2	1994	Treatment of astrocytes with interleukin-1 beta (IL-1) or the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) increased NGF mRNA content by six- to 10-fold, followed in time by increases in cell content and cell secretion of NGF.	Tetradecanoylphorbol Acetate	133-136	interleukin 1 beta	Rattus norvegicus	29-47	
8395530-4	1993	Pretreatment of the cells with TPA (10(-7) M) abolished the subsequent response to IL-1 beta, TGF-alpha, and EGF and at the same time resulted in > 90% reduction of cytosolic protein kinase C activity.	Tetradecanoylphorbol Acetate	31-34	interleukin 1 beta	Rattus norvegicus	83-92	
1907704-5	1991	The secretion of FSH and LH mediated by an activator of protein kinase C, phorbol 12-myristate 13-acetate, was also significantly suppressed by pretreatment with IL-1 beta for 48 hr.	Tetradecanoylphorbol Acetate	74-105	interleukin 1 beta	Rattus norvegicus	162-171	
23775412-5	2013	The expression of PAR4 in cultured DRG neurons was also assessed after treatment with IL-1beta with pre-addition of phorbol-12-myristate 13-acetate (PMA, a PKC activator) or chelerythrine chloride (a PKC inhibitor).	Tetradecanoylphorbol Acetate	116-147	interleukin 1 beta	Rattus norvegicus	86-94	
23775412-8	2013	This IL-1beta effect was enhanced in DRG neurons when DRG cultures were pre-treatment with the PMA.	Tetradecanoylphorbol Acetate	95-98	interleukin 1 beta	Rattus norvegicus	5-13