PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29710490-8 2018 Therefore, the result demonstrates that the anti-metastatic effects of a proton beam in TPA-treated HepG2 cells are associated with the inhibition of MMP-9 activity and the down-regulations of MMP-9, uPA, uPAR, Snail-1 and VEGF gene expression via the p38 MAPK/c-Fos signaling pathway. Tetradecanoylphorbol Acetate 88-91 snail family transcriptional repressor 1 Homo sapiens 211-218 29710490-6 2018 Furthermore, a proton beam suppressed TPA-induced gene expressions of urokinase plasminogen activator (uPA), uPA receptor (uPAR), Snail-1 and vascular endothelial growth factor (VEGF) in HepG2 cells in a dose-dependent manner. Tetradecanoylphorbol Acetate 38-41 snail family transcriptional repressor 1 Homo sapiens 130-137 20046424-8 2009 Treatment of cancer cells with phorbol 12-myristate 13-acetate increased the expressions of COX-2 and Snail, decreased 15-hydroxyprostaglandin dehydrogenase expression, and increased the cells" motility. Tetradecanoylphorbol Acetate 31-62 snail family transcriptional repressor 1 Homo sapiens 102-107 24135872-8 2013 We found that TPA triggered the formation of a complex between Snail and beta-catenin that activated the Wnt pathway. Tetradecanoylphorbol Acetate 14-17 snail family transcriptional repressor 1 Homo sapiens 63-68 22160590-5 2011 Treatment with TPA modified the activity of phosphoPKCalpha and caused an increase of the Snail family members Snail, Slug and Smad-interacting protein 1 and a decrease of E-cadherin. Tetradecanoylphorbol Acetate 15-18 snail family transcriptional repressor 1 Homo sapiens 90-95 22160590-5 2011 Treatment with TPA modified the activity of phosphoPKCalpha and caused an increase of the Snail family members Snail, Slug and Smad-interacting protein 1 and a decrease of E-cadherin. Tetradecanoylphorbol Acetate 15-18 snail family transcriptional repressor 1 Homo sapiens 111-116 20121949-5 2010 Gene expression of EGR-1, Snail and SP-1 can be induced by TPA within 0.5-6 h. In addition, basal levels of SP-1, but not of the other two transcriptional factors, were observed. Tetradecanoylphorbol Acetate 59-62 snail family transcriptional repressor 1 Homo sapiens 26-31 20121949-6 2010 Blockade of TPA-induced gene expression of Snail, EGR-1 or SP-1 suppressed activation of the p15-pro228 reporter plasmid harboring the TPA-responsive element. Tetradecanoylphorbol Acetate 12-15 snail family transcriptional repressor 1 Homo sapiens 43-48 20121949-6 2010 Blockade of TPA-induced gene expression of Snail, EGR-1 or SP-1 suppressed activation of the p15-pro228 reporter plasmid harboring the TPA-responsive element. Tetradecanoylphorbol Acetate 135-138 snail family transcriptional repressor 1 Homo sapiens 43-48 20121949-8 2010 In an EMSA, a DNA-protein complex was elevated by TPA, which can be blocked by antibodies against EGR-1, SP-1 or Snail at 6 h. Immunoprecipitation/western blotting demonstrated that TPA could trigger the association of EGR-1 with Snail or SP-1. Tetradecanoylphorbol Acetate 50-53 snail family transcriptional repressor 1 Homo sapiens 113-118 20121949-8 2010 In an EMSA, a DNA-protein complex was elevated by TPA, which can be blocked by antibodies against EGR-1, SP-1 or Snail at 6 h. Immunoprecipitation/western blotting demonstrated that TPA could trigger the association of EGR-1 with Snail or SP-1. Tetradecanoylphorbol Acetate 50-53 snail family transcriptional repressor 1 Homo sapiens 230-235 20121949-8 2010 In an EMSA, a DNA-protein complex was elevated by TPA, which can be blocked by antibodies against EGR-1, SP-1 or Snail at 6 h. Immunoprecipitation/western blotting demonstrated that TPA could trigger the association of EGR-1 with Snail or SP-1. Tetradecanoylphorbol Acetate 182-185 snail family transcriptional repressor 1 Homo sapiens 113-118 20121949-8 2010 In an EMSA, a DNA-protein complex was elevated by TPA, which can be blocked by antibodies against EGR-1, SP-1 or Snail at 6 h. Immunoprecipitation/western blotting demonstrated that TPA could trigger the association of EGR-1 with Snail or SP-1. Tetradecanoylphorbol Acetate 182-185 snail family transcriptional repressor 1 Homo sapiens 230-235 20121949-9 2010 Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. Tetradecanoylphorbol Acetate 125-128 snail family transcriptional repressor 1 Homo sapiens 104-109 20121949-9 2010 Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. Tetradecanoylphorbol Acetate 125-128 snail family transcriptional repressor 1 Homo sapiens 217-222 20121949-9 2010 Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. Tetradecanoylphorbol Acetate 125-128 snail family transcriptional repressor 1 Homo sapiens 217-222 20121949-9 2010 Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. Tetradecanoylphorbol Acetate 169-172 snail family transcriptional repressor 1 Homo sapiens 104-109 20121949-9 2010 Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. Tetradecanoylphorbol Acetate 169-172 snail family transcriptional repressor 1 Homo sapiens 217-222 20121949-9 2010 Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. Tetradecanoylphorbol Acetate 169-172 snail family transcriptional repressor 1 Homo sapiens 217-222 20121949-9 2010 Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. Tetradecanoylphorbol Acetate 169-172 snail family transcriptional repressor 1 Homo sapiens 104-109 20121949-9 2010 Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. Tetradecanoylphorbol Acetate 169-172 snail family transcriptional repressor 1 Homo sapiens 217-222 20121949-9 2010 Furthermore, a double chromatin immunoprecipitation assay verified that EGR-1 could form a complex with Snail or SP-1 on the TPA-responsive element after treatment with TPA for 2-6 h. Finally, we demonstrated a novel Snail-target region which could be bound by Snail and was also required for TPA-induced p15-pro228 activation. Tetradecanoylphorbol Acetate 169-172 snail family transcriptional repressor 1 Homo sapiens 217-222 20121949-10 2010 In conclusion, Snail associates with EGR-1 and SP-1 to mediate TPA-induced transcriptional upregulation of p15(INK4b) in HepG2. Tetradecanoylphorbol Acetate 63-66 snail family transcriptional repressor 1 Homo sapiens 15-20 29259250-3 2017 Herein, we investigated how Snail upregulated transcription of ZEB1 and MMP9 induced by the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA) in hepatoma cell HepG2. Tetradecanoylphorbol Acetate 107-144 snail family transcriptional repressor 1 Homo sapiens 28-33 29259250-3 2017 Herein, we investigated how Snail upregulated transcription of ZEB1 and MMP9 induced by the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA) in hepatoma cell HepG2. Tetradecanoylphorbol Acetate 146-149 snail family transcriptional repressor 1 Homo sapiens 28-33 29259250-4 2017 According to deletion mapping and site directed mutagenesis analysis, the TPA-responsive elements on both MMP9 and ZEB1 promoters locate on a putative EGR1 and SP1 overlapping region coupled with an upstream proposed Snail binding motif TCACA. Tetradecanoylphorbol Acetate 74-77 snail family transcriptional repressor 1 Homo sapiens 217-222 29259250-5 2017 Consistently, chromatin immunoprecipitation (ChIP) assay showed TPA triggered binding of Snail, EGR1 and SP1 on MMP9 and ZEB1 promoters. Tetradecanoylphorbol Acetate 64-67 snail family transcriptional repressor 1 Homo sapiens 89-94 29259250-6 2017 Double ChIP further indicated TPA induced association of Snail with EGR1 and SP1 on both promoters. Tetradecanoylphorbol Acetate 30-33 snail family transcriptional repressor 1 Homo sapiens 57-62 29259250-7 2017 Also, electrophoresis mobility shift assay revealed TPA enhanced binding of Snail with a MMP9 promoter fragment. Tetradecanoylphorbol Acetate 52-55 snail family transcriptional repressor 1 Homo sapiens 76-81 29187870-11 2017 Moreover, the presence of Snail or Twist1 partially blocked phorbol 12-myristate 13-acetate-induced megakaryocyte differentiation, while that of Twist significantly altered imatinib-induced erythroid differentiation. Tetradecanoylphorbol Acetate 60-91 snail family transcriptional repressor 1 Homo sapiens 26-31 26848699-6 2016 In cultured human keratinocytes, TPA induced Snail mRNA expression while suppressing Slug expression, and this differential regulation was due specifically to activation of the TPA receptor. Tetradecanoylphorbol Acetate 33-36 snail family transcriptional repressor 1 Homo sapiens 45-50 20121949-3 2010 This study investigated the detailed mechanisms by which Snail upregulates gene expression of the CDK inhibitor p15(INK4b) in HepG2 induced by the tumor promoter tetradecanoyl phorbol acetate (TPA). Tetradecanoylphorbol Acetate 162-191 snail family transcriptional repressor 1 Homo sapiens 57-62 20121949-3 2010 This study investigated the detailed mechanisms by which Snail upregulates gene expression of the CDK inhibitor p15(INK4b) in HepG2 induced by the tumor promoter tetradecanoyl phorbol acetate (TPA). Tetradecanoylphorbol Acetate 193-196 snail family transcriptional repressor 1 Homo sapiens 57-62 34204745-11 2021 Furthermore, the XN-treatment counteracted the PMA-induced EMT of the A549 cells by the upregulation of E-cadherin and alpha-E-catenin and the downregulation of N-cadherin, vimentin, and Snail-1 expression. Tetradecanoylphorbol Acetate 47-50 snail family transcriptional repressor 1 Homo sapiens 187-194 18183498-2 2008 Real time RT/PCR and Western blot analysis demonstrated that Snail mRNA and protein, respectively, were induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in hepatoma cell HepG2. Tetradecanoylphorbol Acetate 115-151 snail family transcriptional repressor 1 Homo sapiens 61-66 18183498-2 2008 Real time RT/PCR and Western blot analysis demonstrated that Snail mRNA and protein, respectively, were induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in hepatoma cell HepG2. Tetradecanoylphorbol Acetate 153-156 snail family transcriptional repressor 1 Homo sapiens 61-66 18183498-3 2008 Blockade of gene expression of Snail by antisense oligodeoxynucleotide and/or siRNA technique can prevent not only the TPA-triggered EMT/cell migration and growth inhibition of HepG2 but also TPA-induced down-regulation of E-cadherin and up-regulation of p15(INK4b). Tetradecanoylphorbol Acetate 119-122 snail family transcriptional repressor 1 Homo sapiens 31-36 18183498-3 2008 Blockade of gene expression of Snail by antisense oligodeoxynucleotide and/or siRNA technique can prevent not only the TPA-triggered EMT/cell migration and growth inhibition of HepG2 but also TPA-induced down-regulation of E-cadherin and up-regulation of p15(INK4b). Tetradecanoylphorbol Acetate 192-195 snail family transcriptional repressor 1 Homo sapiens 31-36