PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34437989-0 2021 PMA treatment fosters rat retinal ganglion cell survival via TNF signaling. Tetradecanoylphorbol Acetate 0-3 tumor necrosis factor Rattus norvegicus 61-64 34437989-11 2021 These data suggest that PMA treatment induces IL1beta and TNF-alpha release and modulation of TNFRI/TNFRII expression promoting RGCs survival after axotomy. Tetradecanoylphorbol Acetate 24-27 tumor necrosis factor Rattus norvegicus 58-67 34437989-4 2021 We hypothesize that the increase in RGCs survival mediated by PMA treatment depends upon modulation of the levels of IL-1beta and TNF-alpha. Tetradecanoylphorbol Acetate 62-65 tumor necrosis factor Rattus norvegicus 130-139 34437989-5 2021 The effect of PMA treatment was assayed on cell viability, caspase 3 activation, TNF-alpha and IL-1beta release and TNF receptor type I (TNFRI) and TNF receptor type II (TNFRII) levels. Tetradecanoylphorbol Acetate 14-17 tumor necrosis factor Rattus norvegicus 81-90 34437989-6 2021 PMA treatment increases IL-1beta and TNF-alpha levels in 15 minutes in culture and increases the release of both cytokines after 30 minutes and 24h, respectively. Tetradecanoylphorbol Acetate 0-3 tumor necrosis factor Rattus norvegicus 37-46 34437989-7 2021 Both IL-1beta and TNF-alpha levels decrease after 48h of PMA treatment. Tetradecanoylphorbol Acetate 57-60 tumor necrosis factor Rattus norvegicus 18-27 29497296-7 2018 In addition, phorbol-12-myristate-13-acetate was injected intraperitoneally immediately after the anti-TNF-alpha antibody microinjection. Tetradecanoylphorbol Acetate 13-44 tumor necrosis factor Rattus norvegicus 103-112 2824494-2 1987 Preexposure of several different types of cells with only biologically active tumor promoter, i.e. 4 beta-phorbol 12-myristate 13-acetate (PMA), inhibited the specific binding of rTNF-alpha to its receptor. Tetradecanoylphorbol Acetate 101-137 tumor necrosis factor Rattus norvegicus 179-189 2824494-2 1987 Preexposure of several different types of cells with only biologically active tumor promoter, i.e. 4 beta-phorbol 12-myristate 13-acetate (PMA), inhibited the specific binding of rTNF-alpha to its receptor. Tetradecanoylphorbol Acetate 139-142 tumor necrosis factor Rattus norvegicus 179-189 32626908-7 2020 Microglia in the group receiving 72 h of PMA stimulation displayed the highest percentage of cells arrested in G0/G1, the highest amount of senescence-associated expression of p53 and p21, and the most prominent secretion of TNF-alpha and IL-1beta. Tetradecanoylphorbol Acetate 41-44 tumor necrosis factor Rattus norvegicus 225-234 27087645-5 2016 Oleamide was identified as an active compound of ALE, which attenuated the secretion of histamine and the production of tumor necrosis factor (TNF)-alpha and interleukin-4 (IL-4) in cells treated with compound 48/80 or A23187/phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 226-251 tumor necrosis factor Rattus norvegicus 120-153 28396116-3 2017 Beta2-adrenergic receptor (beta2AR) agonists were identified as the most potent inhibitors of phorbol myristate acetate-induced tumor necrosis factor-alpha production in rat bone marrow macrophages. Tetradecanoylphorbol Acetate 94-119 tumor necrosis factor Rattus norvegicus 128-155 18945317-5 2009 TNF-alpha release by epidermal cells induced by lipopolysaccharide, 12-O-tetradecanoyl-phorbol-13-acetate and the contact allergen dinitrochlorobenzene was assessed by the L929 biological assay. Tetradecanoylphorbol Acetate 68-105 tumor necrosis factor Rattus norvegicus 0-9 26721363-8 2016 Treatment with Go6976 significantly ameliorated the PMA-induced oxidative stress parameters, decreased tissue TNF-alpha level, and lung edema. Tetradecanoylphorbol Acetate 52-55 tumor necrosis factor Rattus norvegicus 110-119 15579495-9 2005 The enhanced production of TNF-alpha, superoxide anion, and nitrite by isolated alveolar macrophages in response to lipopolysaccharide (3 microg/ml), PMA (10 nM), and/or zymosan (100 particles/cell) did not differ between vehicle- and capsaicin-pretreated rats. Tetradecanoylphorbol Acetate 150-153 tumor necrosis factor Rattus norvegicus 27-36 12887999-7 2003 Incubating dental follicle cells with phorbolmyristate acetate (PMA), a PKC activator, significantly up-regulated TNF-alpha gene expression in a dosage-dependent manner. Tetradecanoylphorbol Acetate 38-62 tumor necrosis factor Rattus norvegicus 114-123 12887999-7 2003 Incubating dental follicle cells with phorbolmyristate acetate (PMA), a PKC activator, significantly up-regulated TNF-alpha gene expression in a dosage-dependent manner. Tetradecanoylphorbol Acetate 64-67 tumor necrosis factor Rattus norvegicus 114-123 11199339-1 2000 Production of interleukin (IL)-1 beta, IL-6 and tumor necrosis factor (TNF)-alpha by rat corneal epithelial cells in response to lipopolysaccharide and phorbol-12-myristate-13-acetate (PMA) was tested. Tetradecanoylphorbol Acetate 152-183 tumor necrosis factor Rattus norvegicus 48-81 12353857-0 2002 Nuclear factor-kappaB and TNF-alpha mediate gastric ulceration induced by phorbol myristate acetate. Tetradecanoylphorbol Acetate 74-99 tumor necrosis factor Rattus norvegicus 26-35 11199339-1 2000 Production of interleukin (IL)-1 beta, IL-6 and tumor necrosis factor (TNF)-alpha by rat corneal epithelial cells in response to lipopolysaccharide and phorbol-12-myristate-13-acetate (PMA) was tested. Tetradecanoylphorbol Acetate 185-188 tumor necrosis factor Rattus norvegicus 48-81 10209302-4 1999 Pretreatment with 0.1-100 nM TNF-alpha for 60 min resulted in a significant decrease in 10 nM insulin- or 1 microM 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced [3H]2-deoxyglucose uptake without affecting basal glucose uptake. Tetradecanoylphorbol Acetate 115-152 tumor necrosis factor Rattus norvegicus 29-38 10209302-4 1999 Pretreatment with 0.1-100 nM TNF-alpha for 60 min resulted in a significant decrease in 10 nM insulin- or 1 microM 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced [3H]2-deoxyglucose uptake without affecting basal glucose uptake. Tetradecanoylphorbol Acetate 154-157 tumor necrosis factor Rattus norvegicus 29-38 10209302-6 1999 10 nM TNF-alpha pretreatment also suppressed 10 nM insulin- and 1 microM TPA-induced increases in membrane-associated PKCbeta and PKCzeta. Tetradecanoylphorbol Acetate 73-76 tumor necrosis factor Rattus norvegicus 6-15 9950771-14 1999 However, activation of PKC by phorbol 12-myristate 13-acetate (PMA) dramatically increased cellular resistance to the apoptotic effect of TNF-alpha. Tetradecanoylphorbol Acetate 30-61 tumor necrosis factor Rattus norvegicus 138-147 9950771-14 1999 However, activation of PKC by phorbol 12-myristate 13-acetate (PMA) dramatically increased cellular resistance to the apoptotic effect of TNF-alpha. Tetradecanoylphorbol Acetate 63-66 tumor necrosis factor Rattus norvegicus 138-147 9754866-3 1998 TREATMENT: Cells were treated with TG, CPA, DTBHQ, DTAHQ and MTBHQ for 3 h in the presence of 12-Otetradecanoylphorbol-13-acetate (TPA) and released TNF-alpha from the cells was measured (n > or = 4). Tetradecanoylphorbol Acetate 94-129 tumor necrosis factor Rattus norvegicus 149-158 9865597-3 1998 The release of TNF-alpha required both a Ca2(+)-ATPase inhibitor and 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 69-105 tumor necrosis factor Rattus norvegicus 15-24 9865597-3 1998 The release of TNF-alpha required both a Ca2(+)-ATPase inhibitor and 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 107-110 tumor necrosis factor Rattus norvegicus 15-24 7779996-6 1995 Independent of the differentiative state of the granulosa cells, TNF alpha suppressed FSH-stimulated tPA activity, but potentiated FSH-induced uPA activity in undifferentiated granulosa cells. Tetradecanoylphorbol Acetate 101-104 tumor necrosis factor Rattus norvegicus 65-74 9417811-6 1997 Exposure of osteoblasts to a high dose of phorbol myristoyl acetate (PMA) to deplete PKC activity abolished CGRP-mediated TNF-alpha suppression. Tetradecanoylphorbol Acetate 69-72 tumor necrosis factor Rattus norvegicus 122-131 9048615-6 1997 TNF alpha action on PAI-1, like that of TGF alpha demonstrated previously, was masked by a preexposure to phorbol myristate acetate (a stimulator of protein kinase C) and strongly reduced by staurosporine (an inhibitor of the protein kinase C). Tetradecanoylphorbol Acetate 106-131 tumor necrosis factor Rattus norvegicus 0-9 7517419-0 1994 TNF-alpha associated with fibronectin enhances phorbol myristate acetate- or antigen-mediated integrin-dependent adhesion of CD4+ T cells via protein tyrosine phosphorylation. Tetradecanoylphorbol Acetate 47-72 tumor necrosis factor Rattus norvegicus 0-9 7757523-5 1994 Stimulation of LPS- and TNF-treated PMN with phorbol 12-myristate 13-acetate (PMA), opsonized zymosan (OPZ), and anti-rat CD11b/c MAb triggered O2- generation. Tetradecanoylphorbol Acetate 45-76 tumor necrosis factor Rattus norvegicus 24-27 7757523-5 1994 Stimulation of LPS- and TNF-treated PMN with phorbol 12-myristate 13-acetate (PMA), opsonized zymosan (OPZ), and anti-rat CD11b/c MAb triggered O2- generation. Tetradecanoylphorbol Acetate 78-81 tumor necrosis factor Rattus norvegicus 24-27 7521138-2 1994 Unlike the response to bradykinin, C5a and tumor necrosis factor-alpha (TNF-alpha) previously reported (15), the PMA-induced increase in [Ca2+]i was predominantly dependent on extracellular calcium. Tetradecanoylphorbol Acetate 113-116 tumor necrosis factor Rattus norvegicus 72-81 7517419-4 1994 A brief exposure of CD4+ cells to low dosages of soluble TNF-alpha or of FN- or laminin-bound TNF-alpha synergized with PMA to enhance the integrin-mediated binding of CD4+ cells to these immobilized ECM moieties. Tetradecanoylphorbol Acetate 120-123 tumor necrosis factor Rattus norvegicus 57-66 7517419-4 1994 A brief exposure of CD4+ cells to low dosages of soluble TNF-alpha or of FN- or laminin-bound TNF-alpha synergized with PMA to enhance the integrin-mediated binding of CD4+ cells to these immobilized ECM moieties. Tetradecanoylphorbol Acetate 120-123 tumor necrosis factor Rattus norvegicus 94-103 7517419-5 1994 TNF-alpha-enhanced adhesion of CD4+ cells did not delay or inhibit the subsequent detachment of the cells from the substrate, and adhesion was increased provided the cells were treated with TNF-alpha immediately after their exposure to PMA. Tetradecanoylphorbol Acetate 236-239 tumor necrosis factor Rattus norvegicus 0-9 7517419-5 1994 TNF-alpha-enhanced adhesion of CD4+ cells did not delay or inhibit the subsequent detachment of the cells from the substrate, and adhesion was increased provided the cells were treated with TNF-alpha immediately after their exposure to PMA. Tetradecanoylphorbol Acetate 236-239 tumor necrosis factor Rattus norvegicus 190-199 7517419-8 1994 Soluble, and to a greater extent FN-bound, TNF-alpha synergizes with PMA to intensify protein tyrosine phosphorylation in FN-bound CD4+ cells, and this effect of TNF-alpha was inhibited by inhibitors of tyrosine kinase. Tetradecanoylphorbol Acetate 69-72 tumor necrosis factor Rattus norvegicus 162-171 1898344-5 1991 Treatment in vitro with 1 microM-phorbol 12-myristate 13-acetate (PMA) resulted in a similar percentage increase in glucose use by Kupffer cells prepared from either saline- or TNF-treated rats. Tetradecanoylphorbol Acetate 33-64 tumor necrosis factor Rattus norvegicus 177-180 1327012-0 1992 Tumor necrosis factor-alpha and interleukin-1 alpha synergistically enhance phorbol myristate acetate-induced superoxide production by rat bone marrow-derived macrophages. Tetradecanoylphorbol Acetate 76-101 tumor necrosis factor Rattus norvegicus 0-27 1327012-6 1992 The biologic response to TNF-alpha and IL-1 alpha was assessed by measurement of superoxide production quantitated by the reduction of cytochrome c in response to phorbol myristate acetate. Tetradecanoylphorbol Acetate 163-188 tumor necrosis factor Rattus norvegicus 25-34 1322286-13 1992 When the cells were pretreated with a high concentration of PMA (1 microM/24 h) to down-regulate PKC, the TNF alpha dose-dependent increase in [3H]thymidine incorporation and decrease in DNA content were only slightly inhibited, suggesting that the main effects of TNF alpha are independent of PKC. Tetradecanoylphorbol Acetate 60-63 tumor necrosis factor Rattus norvegicus 106-115 1322286-13 1992 When the cells were pretreated with a high concentration of PMA (1 microM/24 h) to down-regulate PKC, the TNF alpha dose-dependent increase in [3H]thymidine incorporation and decrease in DNA content were only slightly inhibited, suggesting that the main effects of TNF alpha are independent of PKC. Tetradecanoylphorbol Acetate 60-63 tumor necrosis factor Rattus norvegicus 265-274 8381194-5 1993 TNF-alpha synthesis and secretion was, however, induced to high levels by stimulation of the B-CLL cells with interleukin-2 (IL-2) after activation by 12-O-tetradecanoylphorbol-13-acetate (TPA) or Staphylococcus aureus Cowan strain I (SAC) and B-cell stimulatory factor-MP6 (thioredoxin). Tetradecanoylphorbol Acetate 151-187 tumor necrosis factor Rattus norvegicus 0-9 8381194-5 1993 TNF-alpha synthesis and secretion was, however, induced to high levels by stimulation of the B-CLL cells with interleukin-2 (IL-2) after activation by 12-O-tetradecanoylphorbol-13-acetate (TPA) or Staphylococcus aureus Cowan strain I (SAC) and B-cell stimulatory factor-MP6 (thioredoxin). Tetradecanoylphorbol Acetate 189-192 tumor necrosis factor Rattus norvegicus 0-9 8381194-6 1993 A moderate increase in TNF-alpha secretion was also induced by TPA or IL-2 alone. Tetradecanoylphorbol Acetate 63-66 tumor necrosis factor Rattus norvegicus 23-32 8381194-8 1993 The cell surface expression of TNF-alpha receptors (TNF-R), as determined by binding assay using 125I-labelled recombinant TNF-alpha (rTNF-alpha), was also induced after SAC or TPA activation, but shed receptors (TNF-binding proteins) were only observed after TPA activation. Tetradecanoylphorbol Acetate 177-180 tumor necrosis factor Rattus norvegicus 31-40 8381194-8 1993 The cell surface expression of TNF-alpha receptors (TNF-R), as determined by binding assay using 125I-labelled recombinant TNF-alpha (rTNF-alpha), was also induced after SAC or TPA activation, but shed receptors (TNF-binding proteins) were only observed after TPA activation. Tetradecanoylphorbol Acetate 177-180 tumor necrosis factor Rattus norvegicus 123-132 8381194-8 1993 The cell surface expression of TNF-alpha receptors (TNF-R), as determined by binding assay using 125I-labelled recombinant TNF-alpha (rTNF-alpha), was also induced after SAC or TPA activation, but shed receptors (TNF-binding proteins) were only observed after TPA activation. Tetradecanoylphorbol Acetate 177-180 tumor necrosis factor Rattus norvegicus 134-144 8381194-8 1993 The cell surface expression of TNF-alpha receptors (TNF-R), as determined by binding assay using 125I-labelled recombinant TNF-alpha (rTNF-alpha), was also induced after SAC or TPA activation, but shed receptors (TNF-binding proteins) were only observed after TPA activation. Tetradecanoylphorbol Acetate 260-263 tumor necrosis factor Rattus norvegicus 31-40 8381194-8 1993 The cell surface expression of TNF-alpha receptors (TNF-R), as determined by binding assay using 125I-labelled recombinant TNF-alpha (rTNF-alpha), was also induced after SAC or TPA activation, but shed receptors (TNF-binding proteins) were only observed after TPA activation. Tetradecanoylphorbol Acetate 260-263 tumor necrosis factor Rattus norvegicus 134-144 8118227-5 1993 TNF-alpha, phorbol ester 12-myristate 13-acetate (PMA), and calcium ionophore (CI) A23817 all inhibited [125I]iodide transport, but high doses of PMA and CI also blocked the inhibitory action of TNF-alpha on [125I]iodide transport. Tetradecanoylphorbol Acetate 146-149 tumor necrosis factor Rattus norvegicus 195-204 1898344-5 1991 Treatment in vitro with 1 microM-phorbol 12-myristate 13-acetate (PMA) resulted in a similar percentage increase in glucose use by Kupffer cells prepared from either saline- or TNF-treated rats. Tetradecanoylphorbol Acetate 66-69 tumor necrosis factor Rattus norvegicus 177-180