PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10574624-2 1999 Both the basal and 12-O-tetradecanoyl phorbol-13-acetate (TPA)-stimulated production of KSHV/HHV-8 mature virions was strongly inhibited in genetically modified IFN-producing BCBL-1 cells as compared with parental or control transduced counterparts. Tetradecanoylphorbol Acetate 19-56 interferon alpha 1 Homo sapiens 161-164 18635599-7 2008 We show that lipid rafts are required for enterocyte migration, that IFN displaces Cx43 from lipid rafts, and that the phorbol ester phorbol 12-myristate 13-acetate (PMA) restores Cx43 to lipid rafts after treatment with IFN in a protein kinase C-dependent manner. Tetradecanoylphorbol Acetate 133-164 interferon alpha 1 Homo sapiens 221-224 18635599-7 2008 We show that lipid rafts are required for enterocyte migration, that IFN displaces Cx43 from lipid rafts, and that the phorbol ester phorbol 12-myristate 13-acetate (PMA) restores Cx43 to lipid rafts after treatment with IFN in a protein kinase C-dependent manner. Tetradecanoylphorbol Acetate 166-169 interferon alpha 1 Homo sapiens 221-224 15448338-9 2004 When IFN-gamma was present during TPA stimulation, the production of infectious virus was reduced by at least a 60 %, and IFN-alpha fully blocked TPA-induced production of infectious virus. Tetradecanoylphorbol Acetate 146-149 interferon alpha 1 Homo sapiens 122-131 10574624-2 1999 Both the basal and 12-O-tetradecanoyl phorbol-13-acetate (TPA)-stimulated production of KSHV/HHV-8 mature virions was strongly inhibited in genetically modified IFN-producing BCBL-1 cells as compared with parental or control transduced counterparts. Tetradecanoylphorbol Acetate 58-61 interferon alpha 1 Homo sapiens 161-164 10574624-6 1999 TPA treatment, which did not significantly affect the viability of the parental and control BCBL-1 cells, resulted in the apoptotic death of up to 70% of the IFN-producing cell population. Tetradecanoylphorbol Acetate 0-3 interferon alpha 1 Homo sapiens 158-161 10524248-3 1999 The region from -366 to -117 bp, relative to the translational start site, contains three sequence motifs that resemble interferon stimulated response elements/interferon regulatory factor elements (ISRE/IRF-E), which are required for stimulation of the IFN-alpha-response by the PKC activator, 12-O-tetradecanoyl phorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 295-332 interferon alpha 1 Homo sapiens 254-263 10524248-3 1999 The region from -366 to -117 bp, relative to the translational start site, contains three sequence motifs that resemble interferon stimulated response elements/interferon regulatory factor elements (ISRE/IRF-E), which are required for stimulation of the IFN-alpha-response by the PKC activator, 12-O-tetradecanoyl phorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 334-337 interferon alpha 1 Homo sapiens 254-263 10524248-5 1999 Likewise, introduction of point mutations into either of these IRF-Es decreases stimulation of IFN-alpha induction by TPA and constructs containing point mutations in both upstream IRF-Es are nonresponsive to TPA. Tetradecanoylphorbol Acetate 118-121 interferon alpha 1 Homo sapiens 95-104 10196299-3 1999 IFN-alpha inhibited in a dose-dependent manner the amplification of HHV-8 DNA in BCBL-1 cells induced to lytic infection with tetradecanoyl phorbol acetate (TPA). Tetradecanoylphorbol Acetate 126-155 interferon alpha 1 Homo sapiens 0-3 10196299-3 1999 IFN-alpha inhibited in a dose-dependent manner the amplification of HHV-8 DNA in BCBL-1 cells induced to lytic infection with tetradecanoyl phorbol acetate (TPA). Tetradecanoylphorbol Acetate 157-160 interferon alpha 1 Homo sapiens 0-3 10196299-7 1999 Conversely, the addition of anti-IFN-alpha Ab to TPA-induced BCBL-1 cells resulted in a larger number of mature enveloped particles and in a more extensive cytopathic effect due to the neutralization of the endogenous IFN produced by these cells. Tetradecanoylphorbol Acetate 49-52 interferon alpha 1 Homo sapiens 33-42 10196299-7 1999 Conversely, the addition of anti-IFN-alpha Ab to TPA-induced BCBL-1 cells resulted in a larger number of mature enveloped particles and in a more extensive cytopathic effect due to the neutralization of the endogenous IFN produced by these cells. Tetradecanoylphorbol Acetate 49-52 interferon alpha 1 Homo sapiens 33-36 9809619-4 1998 Phorbol myristate acetate (PMA) greatly enhanced IFN yields in the presence of ionophores but had no significant influence on IL-4 production. Tetradecanoylphorbol Acetate 0-25 interferon alpha 1 Homo sapiens 49-52 10656176-3 1999 Pretreatment of MRC-5 and phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells with IFN-alpha or IFN-gamma for 24 hr prior to the infection reduced the number of infected cells and virus yield. Tetradecanoylphorbol Acetate 26-57 interferon alpha 1 Homo sapiens 89-98 10656176-3 1999 Pretreatment of MRC-5 and phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells with IFN-alpha or IFN-gamma for 24 hr prior to the infection reduced the number of infected cells and virus yield. Tetradecanoylphorbol Acetate 59-62 interferon alpha 1 Homo sapiens 89-98 9809619-4 1998 Phorbol myristate acetate (PMA) greatly enhanced IFN yields in the presence of ionophores but had no significant influence on IL-4 production. Tetradecanoylphorbol Acetate 27-30 interferon alpha 1 Homo sapiens 49-52 7557232-3 1995 TPA inhibited proliferation and induced macrophage-like differentiation of primary AML blast cells and these changes were accompanied by modulation of IFN-alpha expression in CM. Tetradecanoylphorbol Acetate 0-3 interferon alpha 1 Homo sapiens 151-160 9458327-5 1998 PKC activator, phorbol 12-myristate 13-acetate (PMA) and PKA activator, dibutyryl cAMP could replace LPS in priming the cells for IFN- stimulation but 8-bromo-cGMP did not. Tetradecanoylphorbol Acetate 15-46 interferon alpha 1 Homo sapiens 130-133 9458327-5 1998 PKC activator, phorbol 12-myristate 13-acetate (PMA) and PKA activator, dibutyryl cAMP could replace LPS in priming the cells for IFN- stimulation but 8-bromo-cGMP did not. Tetradecanoylphorbol Acetate 48-51 interferon alpha 1 Homo sapiens 130-133 8908614-0 1996 Augmentation of interferon production after cell-differentiation of U937 cells by TPA. Tetradecanoylphorbol Acetate 82-85 interferon alpha 1 Homo sapiens 16-26 8908614-4 1996 Induction of cell differentiation and augmentation of IFN production by TPA were demonstrated in U937 cells persistently infected with mumps virus (U937-MP). Tetradecanoylphorbol Acetate 72-75 interferon alpha 1 Homo sapiens 54-57 9916491-2 1998 Luminol-dependent Chemiluminescence (LmCL) responses were inhibited by a high concentration of IFN-alpha (more than 1 x 10(4) IU/ml) when opsonized zymosan (OZ) and phorbol 12-myristate 13-acetate (PMA) were used as stimulants. Tetradecanoylphorbol Acetate 165-196 interferon alpha 1 Homo sapiens 95-104 9916491-2 1998 Luminol-dependent Chemiluminescence (LmCL) responses were inhibited by a high concentration of IFN-alpha (more than 1 x 10(4) IU/ml) when opsonized zymosan (OZ) and phorbol 12-myristate 13-acetate (PMA) were used as stimulants. Tetradecanoylphorbol Acetate 198-201 interferon alpha 1 Homo sapiens 95-104 9260891-3 1997 Down-regulation of PKC by prolonged treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) also blocks induction of 2-5A synthetase mRNAs and decreases both constitutive and IFN-alpha-induced enzymatic activity. Tetradecanoylphorbol Acetate 51-87 interferon alpha 1 Homo sapiens 177-186 9260891-3 1997 Down-regulation of PKC by prolonged treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) also blocks induction of 2-5A synthetase mRNAs and decreases both constitutive and IFN-alpha-induced enzymatic activity. Tetradecanoylphorbol Acetate 89-92 interferon alpha 1 Homo sapiens 177-186 9260891-4 1997 Cotreatment of cells with TPA and IFN-alpha increases induction of 2-5A synthetase mRNAs above that seen in cells treated with IFN-alpha alone. Tetradecanoylphorbol Acetate 26-29 interferon alpha 1 Homo sapiens 127-136 8639843-4 1996 In highly purified CD4+ T cells, IFN-alpha upregulated IL-10 mRNA upon activation with phytohemagglutinin and phorbol myristate acetate. Tetradecanoylphorbol Acetate 110-135 interferon alpha 1 Homo sapiens 33-42 8657115-6 1996 Moreover, PMA caused the dephosphorylation of Tyk2 but not of Jak1, which was activated by IFN. Tetradecanoylphorbol Acetate 10-13 interferon alpha 1 Homo sapiens 91-94 7679173-1 1993 In this paper we report that differentiation of the human promyelocytic leukemia cell line, HL60, along the myelocytic pathway, induced by retinoic acid (RA), or monocytic pathway, induced by phorbol-myristate acetate (PMA) and gamma interferon (IFN), was accompanied by a significant decline in 1,25-dihydroxycholecalciferol (1,25(OH)2D3) binding (control: 30.3 +/- 3.0 fM/10(6) cells; RA treated: 6.8 + 2.5 fM/10(6) cells; PMA treated: 12.3 +/- 6.7 fM/10(6) cells and IFN treated: 16.0 +/- 5.0 fM/10(6) cells). Tetradecanoylphorbol Acetate 192-217 interferon alpha 1 Homo sapiens 228-250 8375736-2 1993 In order to determine whether the cytolytic activity induced by IFN alpha was activated through a pathway involving the activation of PKC, the human ovarian carcinoma cell line Caov-3 was exposed to phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 232-235 interferon alpha 1 Homo sapiens 64-73 8304411-3 1994 Exposure of IFN-primed macrophages to polyinosinic-polycytidylic acid in the presence of the PKC inhibitors H-7 or sphingosine or after downregulation of PKC with phorbol myristate acetate markedly inhibited Bf synthesis. Tetradecanoylphorbol Acetate 163-188 interferon alpha 1 Homo sapiens 12-15 8375736-2 1993 In order to determine whether the cytolytic activity induced by IFN alpha was activated through a pathway involving the activation of PKC, the human ovarian carcinoma cell line Caov-3 was exposed to phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 199-230 interferon alpha 1 Homo sapiens 64-73 8486772-3 1993 The lymphokine interferon-gamma (IFN) dramatically inhibited the accumulation of apo E in the supernatant of human monocytic THP-1 cells when present during phorbol myristate acetate-induced differentiation. Tetradecanoylphorbol Acetate 157-182 interferon alpha 1 Homo sapiens 4-37 7679173-1 1993 In this paper we report that differentiation of the human promyelocytic leukemia cell line, HL60, along the myelocytic pathway, induced by retinoic acid (RA), or monocytic pathway, induced by phorbol-myristate acetate (PMA) and gamma interferon (IFN), was accompanied by a significant decline in 1,25-dihydroxycholecalciferol (1,25(OH)2D3) binding (control: 30.3 +/- 3.0 fM/10(6) cells; RA treated: 6.8 + 2.5 fM/10(6) cells; PMA treated: 12.3 +/- 6.7 fM/10(6) cells and IFN treated: 16.0 +/- 5.0 fM/10(6) cells). Tetradecanoylphorbol Acetate 192-217 interferon alpha 1 Homo sapiens 246-249 1628655-0 1992 Transcriptional activation of human (2"-5")oligoadenylate synthetase gene expression by the phorbol ester 12-O-tetradecanoyl-phorbol 13-acetate in type-I-interferon-treated HL-60 and HeLa cells. Tetradecanoylphorbol Acetate 106-143 interferon alpha 1 Homo sapiens 154-164 1406637-2 1992 In addition, phorbol esters may promote cell growth by the inhibition of expression of cellular gene products regulated by antiproliferative agents such as interferons (IFN)s. In human diploid fibroblasts, phorbol 12-myristate 13-acetate (PMA) selectively inhibits the IFN-alpha-induced cellular gene ISG54. Tetradecanoylphorbol Acetate 206-237 interferon alpha 1 Homo sapiens 269-278 1655906-1 1991 The phorbol ester PMA efficiently inhibits the in vitro IFN-alpha and -beta responses in human blood monocytes induced by Sendai virus and in natural IFN-producing cells induced by glutaraldehyde-fixed herpes simplex virus-infected human amnion (WISH) cells. Tetradecanoylphorbol Acetate 18-21 interferon alpha 1 Homo sapiens 56-75 1655906-4 1991 The synthetic diacylglycerol 1-oleoyl-2-acetylglycerol has the same effects as PMA, and the protein kinase inhibitor staurosporine prevents the PMA-mediated inhibition of IFN-alpha/beta expression. Tetradecanoylphorbol Acetate 79-82 interferon alpha 1 Homo sapiens 171-180 1655906-4 1991 The synthetic diacylglycerol 1-oleoyl-2-acetylglycerol has the same effects as PMA, and the protein kinase inhibitor staurosporine prevents the PMA-mediated inhibition of IFN-alpha/beta expression. Tetradecanoylphorbol Acetate 144-147 interferon alpha 1 Homo sapiens 171-180 1964949-7 1990 In contrast, the antiviral effects of IFN-alpha were not blocked by H-7, or by previous down-regulation of PKC by prolonged treatment of HEF cells with TPA. Tetradecanoylphorbol Acetate 152-155 interferon alpha 1 Homo sapiens 38-47 1712443-5 1991 The same prolonged treatment of M1 cells with PMA did not interfere with the ability of another cytokine, transforming growth factor beta (TGF-beta), to induce the normal type of G0/G1 arrest further supporting the specificity of the effect towards IFN responses. Tetradecanoylphorbol Acetate 46-49 interferon alpha 1 Homo sapiens 249-252 2048200-6 1991 Depletion of protein kinase C (PKC) activity from cells by pretreatment of Daudi cells with phorbol.12-myristate 13-acetate (PMA) abolished the G0/G1 arrest induced by both CsA and IFN-alpha. Tetradecanoylphorbol Acetate 125-128 interferon alpha 1 Homo sapiens 181-190 6099864-8 1984 Conventional IFN-gamma inducers, concanavalin A and 12-O-tetradecanoyl-phorbol-13-acetate, further enhanced the production of IFN in this cell line. Tetradecanoylphorbol Acetate 52-89 interferon alpha 1 Homo sapiens 13-16 2135379-4 1990 In monocyte-derived macrophages, both IFN-alpha and IFN-beta stimulated the phorbol myristate acetate (PMA) induced OB response in the patient group as well as in the blood donor control group. Tetradecanoylphorbol Acetate 76-101 interferon alpha 1 Homo sapiens 38-47 2135379-4 1990 In monocyte-derived macrophages, both IFN-alpha and IFN-beta stimulated the phorbol myristate acetate (PMA) induced OB response in the patient group as well as in the blood donor control group. Tetradecanoylphorbol Acetate 103-106 interferon alpha 1 Homo sapiens 38-47 2196473-6 1990 Major induced alterations included down-regulation of CD4 (induced by TPA, and to a lesser extent by IFN-alpha), TPA-induced decrease of cell surface expression of transferrin receptor (unmodified by IFN-alpha) and IFN-alpha induced increase of antigen density (fluorescence intensity) of MHC class I antigen. Tetradecanoylphorbol Acetate 113-116 interferon alpha 1 Homo sapiens 200-209 2196473-6 1990 Major induced alterations included down-regulation of CD4 (induced by TPA, and to a lesser extent by IFN-alpha), TPA-induced decrease of cell surface expression of transferrin receptor (unmodified by IFN-alpha) and IFN-alpha induced increase of antigen density (fluorescence intensity) of MHC class I antigen. Tetradecanoylphorbol Acetate 113-116 interferon alpha 1 Homo sapiens 200-209 2478302-6 1989 The requirement for TcR crosslinking in triggering both secretion of granules and secretion of IFN from CTL was pharmacologically reproduced by the synergistic action of PMA, a protein kinase C activator, and the Ca2+ ionophore A23187. Tetradecanoylphorbol Acetate 170-173 interferon alpha 1 Homo sapiens 95-98 2439242-6 1987 Pretreatment of monocytes with recombinant human interferon (IFN)-gamma or IFN-alpha for 18 hr resulted in enhanced release of labeled arachidonic acid and increased conversion to autocoids after TPA or ionophore stimulation. Tetradecanoylphorbol Acetate 196-199 interferon alpha 1 Homo sapiens 75-84 3585077-7 1987 Therefore, enhanced CL reactivity to PMA or Zymosan observed in the whole blood of the patients" population appears to be due to the presence of interferon in serum blood components as a consequence of IFN-infusion rather than to other symptoms or treatments of the neoplastic diseases, since the relative CL enhancement in patients is abrogated when isolated blood leukocytes are used for CL assay. Tetradecanoylphorbol Acetate 37-40 interferon alpha 1 Homo sapiens 202-205 6206645-5 1984 IFN production was enhanced by the diterpene tumor promoters, TPA and mezerein, but not by classical T-cell mitogens. Tetradecanoylphorbol Acetate 62-65 interferon alpha 1 Homo sapiens 0-3 2127700-8 1990 In both naive and TPA-desensitized human fibroblasts or WISH cells, prolonged IFN treatment induced a desensitized state that was reversible by cycloheximide. Tetradecanoylphorbol Acetate 18-21 interferon alpha 1 Homo sapiens 78-81 2516715-4 1989 The three types of interferons and TPA differed in their absolute TAA-augmenting ability, even in single-cell subclones derived from MCF-7 cells and previously shown to display a differential susceptibility to IFN-alpha augmentation of B1.1 expression. Tetradecanoylphorbol Acetate 35-38 interferon alpha 1 Homo sapiens 210-219 3081575-10 1986 Addition of IFN alpha, 10,000-50,000 U/ml of interleukin 2 or phorbol myristate acetate (PMA) to cord mononuclear cells or of adult monocytes or PMA to cord T cells increased IFN gamma production compared to cells stimulated with concanavalin A (ConA) alone. Tetradecanoylphorbol Acetate 62-87 interferon alpha 1 Homo sapiens 12-32 6170583-1 1981 The diterpene ester 12-O-tetradecanoylphorbol-13-acetate (TPA) and several structurally related compounds were tested for their ability to stimulate interferon (IFN) production in primary cultures of human leukocytes. Tetradecanoylphorbol Acetate 20-56 interferon alpha 1 Homo sapiens 139-165 6327273-5 1982 Treatment of P3HR-1 cells with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or hydrocortisone (HC), which induce similar changes in cell cycle distribution as does IFN, did not induce comparable changes in the rates of protein synthesis. Tetradecanoylphorbol Acetate 70-73 interferon alpha 1 Homo sapiens 163-166 6188944-8 1982 Spontaneously produced IFN was detected more easily in cells transformed by EBV alone than in those transformed by EBV and a tumor promoter, TPA. Tetradecanoylphorbol Acetate 141-144 interferon alpha 1 Homo sapiens 23-26 6170583-1 1981 The diterpene ester 12-O-tetradecanoylphorbol-13-acetate (TPA) and several structurally related compounds were tested for their ability to stimulate interferon (IFN) production in primary cultures of human leukocytes. Tetradecanoylphorbol Acetate 58-61 interferon alpha 1 Homo sapiens 139-165 6170583-2 1981 In cultures of Ficoll-Hypaque-purified mononuclear cells, TPA treatment alone induced only low levels of IFN, but TPA pretreatment of cells caused significant enhancement of IFN yields produced with phytohemagglutinin or several other T cell mitogens. Tetradecanoylphorbol Acetate 58-61 interferon alpha 1 Homo sapiens 105-108 6170583-2 1981 In cultures of Ficoll-Hypaque-purified mononuclear cells, TPA treatment alone induced only low levels of IFN, but TPA pretreatment of cells caused significant enhancement of IFN yields produced with phytohemagglutinin or several other T cell mitogens. Tetradecanoylphorbol Acetate 114-117 interferon alpha 1 Homo sapiens 174-177 6170583-3 1981 In cultures of unprocessed cells derived from plateletpheresis residues or buffy coats, TPA treatment alone induced high levels of IFN and costimulation with TPA and phytohemagglutinin produced some further enhancement of IFN production. Tetradecanoylphorbol Acetate 88-91 interferon alpha 1 Homo sapiens 131-134 6170583-3 1981 In cultures of unprocessed cells derived from plateletpheresis residues or buffy coats, TPA treatment alone induced high levels of IFN and costimulation with TPA and phytohemagglutinin produced some further enhancement of IFN production. Tetradecanoylphorbol Acetate 88-91 interferon alpha 1 Homo sapiens 222-225 6170583-4 1981 Phorbol 12,13-dibutyrate was comparable to TPA in its ability to enhance phytohemagglutinin-induced IFN production. Tetradecanoylphorbol Acetate 43-46 interferon alpha 1 Homo sapiens 100-103 6170583-6 1981 Mezerein, a structurally related diterpene ester, was at least as active as TPA in stimulating IFN production in either Ficoll-Hypaque-purified or unprocessed cells. Tetradecanoylphorbol Acetate 76-79 interferon alpha 1 Homo sapiens 95-98 6170583-7 1981 IFN produced after stimulation with TPA or mezerein, singly or in combination with phytohemagglutinin, had several properties characteristic of IFN-gamma, e.g., it was largely inactivated by dialysis at pH 2, or after exposure to sodium dodecyl sulfate, whereas it was not neutralized by antibody to IFN-alpha and IFN-beta. Tetradecanoylphorbol Acetate 36-39 interferon alpha 1 Homo sapiens 0-3 6170583-7 1981 IFN produced after stimulation with TPA or mezerein, singly or in combination with phytohemagglutinin, had several properties characteristic of IFN-gamma, e.g., it was largely inactivated by dialysis at pH 2, or after exposure to sodium dodecyl sulfate, whereas it was not neutralized by antibody to IFN-alpha and IFN-beta. Tetradecanoylphorbol Acetate 36-39 interferon alpha 1 Homo sapiens 300-309