PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10543370-6 1999 Although phorbol 12-myristate 13-acetate strongly induced p21 and stabilised p53 in the resting transfected Jurkat cells, neither apoptosis nor cell arrest was observed. Tetradecanoylphorbol Acetate 9-40 H3 histone pseudogene 16 Homo sapiens 58-61 9348195-4 1997 Both 1,25-(OH)2D3 and TPA independently up-regulated the vitamin D receptor, p21, and the hypophosphorylated form of retinoblastoma (Rb) protein. Tetradecanoylphorbol Acetate 22-25 H3 histone pseudogene 16 Homo sapiens 77-80 10037143-2 1999 We found that phorbol 12-myristate 13-acetate (PMA) induced upregulation of p21, not only in MCF-7 cells arrested in the G1 phase as previously shown, but also in cells delayed in the G2 phase. Tetradecanoylphorbol Acetate 14-45 H3 histone pseudogene 16 Homo sapiens 76-79 10037143-2 1999 We found that phorbol 12-myristate 13-acetate (PMA) induced upregulation of p21, not only in MCF-7 cells arrested in the G1 phase as previously shown, but also in cells delayed in the G2 phase. Tetradecanoylphorbol Acetate 47-50 H3 histone pseudogene 16 Homo sapiens 76-79 9348195-8 1997 In MCF-7D3Res cells, 1,25-(OH)2D3 treatment had minimal effects on p21 or Rb protein expression, whereas TPA down-regulated Rb protein and transiently up-regulated p21. Tetradecanoylphorbol Acetate 105-108 H3 histone pseudogene 16 Homo sapiens 164-167 8988173-5 1997 In a search for cellular factors that could activate p21 during phorbol ester (TPA)-induced differentiation, we identified AP2 as a regulator of p21 expression. Tetradecanoylphorbol Acetate 79-82 H3 histone pseudogene 16 Homo sapiens 53-56 9278434-3 1997 However, inducible overexpression and activation of the protein kinase Calpha isozyme or the addition of 12-O-tetradecanoylphorbol-13-acetate in the prostate epithelial cell line, LNCaP, resulted in apoptosis preceded by induction of p21 and dephosphorylation of the retinoblastoma protein. Tetradecanoylphorbol Acetate 105-141 H3 histone pseudogene 16 Homo sapiens 234-237 9000576-2 1997 We show that despite p21 induction in 7 of 12 human cancer cell lines treated with PMA, growth inhibition was observed only in two cell lines (SKBr3 breast and LNCaP prostate cancer cells). Tetradecanoylphorbol Acetate 83-86 H3 histone pseudogene 16 Homo sapiens 21-24 9000576-7 1997 Our findings suggest that induction of p21 and down-regulation of c-myc may be necessary steps in a PMA-induced growth-inhibitory pathway in cancer cells. Tetradecanoylphorbol Acetate 100-103 H3 histone pseudogene 16 Homo sapiens 39-42 8988173-5 1997 In a search for cellular factors that could activate p21 during phorbol ester (TPA)-induced differentiation, we identified AP2 as a regulator of p21 expression. Tetradecanoylphorbol Acetate 79-82 H3 histone pseudogene 16 Homo sapiens 145-148 8988173-6 1997 Mutagenesis of an AP2 DNA-binding site within a p21 promoter-luciferase reporter inhibited its activation by either AP2 transfection or TPA stimulation. Tetradecanoylphorbol Acetate 136-139 H3 histone pseudogene 16 Homo sapiens 48-51 8642043-6 1996 7-Hydroxycoumarin decreased the relative amount of intracellular p21ras, and concomitantly a PMA-induced decrease of p21ras GTPase activity could be partially antagonized by 7-hydroxycoumarin. Tetradecanoylphorbol Acetate 93-96 H3 histone pseudogene 16 Homo sapiens 65-68 8663295-1 1996 Desensitization of p21(ras) after stimulation of cells by growth factors and phorbol 12-myristate 13-acetate (PMA) correlates with hyperphosphorylation of the guanine nucleotide exchange factor Son-of-sevenless (Sos) and its dissociation from the adaptor protein Grb2 (Cherniack, A., Klarlund, J. K., Conway, B. R., and Czech, M. P. (1995) J. Biol. Tetradecanoylphorbol Acetate 77-108 H3 histone pseudogene 16 Homo sapiens 19-22 8663295-1 1996 Desensitization of p21(ras) after stimulation of cells by growth factors and phorbol 12-myristate 13-acetate (PMA) correlates with hyperphosphorylation of the guanine nucleotide exchange factor Son-of-sevenless (Sos) and its dissociation from the adaptor protein Grb2 (Cherniack, A., Klarlund, J. K., Conway, B. R., and Czech, M. P. (1995) J. Biol. Tetradecanoylphorbol Acetate 110-113 H3 histone pseudogene 16 Homo sapiens 19-22 8615653-0 1996 Regulation of TNF-alpha and IL-1 gene expression during TPA-induced differentiation of "Malignant histiocytosis" DEL cell line t(5;6) (q35:p21). Tetradecanoylphorbol Acetate 56-59 H3 histone pseudogene 16 Homo sapiens 139-142 1939160-3 1991 Activation of p21ras was not observed when the cells were stimulated with the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and pretreatment with TPA for 16 h, sufficient to down-regulate PKC activity, did not abolish p21ras activation by insulin. Tetradecanoylphorbol Acetate 131-134 H3 histone pseudogene 16 Homo sapiens 14-17 8020607-4 1994 Furthermore, activity of Ki-ras p21 2 h prior to TPA exposure enhanced the inhibitory effect of TPA in quiescent cells. Tetradecanoylphorbol Acetate 49-52 H3 histone pseudogene 16 Homo sapiens 32-35 8020607-4 1994 Furthermore, activity of Ki-ras p21 2 h prior to TPA exposure enhanced the inhibitory effect of TPA in quiescent cells. Tetradecanoylphorbol Acetate 96-99 H3 histone pseudogene 16 Homo sapiens 32-35 8020607-6 1994 The suppression of junctional communication by TPA was completely prevented if the oncogenic p21 had been active for a longer period of time (48 h). Tetradecanoylphorbol Acetate 47-50 H3 histone pseudogene 16 Homo sapiens 93-96 8020607-8 1994 From these results we conclude that there is a cell-state dependence of junctional sensitivity to TPA in NRK cells and that ras p21 activity potentiates the junctional response to TPA. Tetradecanoylphorbol Acetate 180-183 H3 histone pseudogene 16 Homo sapiens 128-131 8139548-0 1994 rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells. Tetradecanoylphorbol Acetate 114-150 H3 histone pseudogene 16 Homo sapiens 65-68 8139548-0 1994 rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells. Tetradecanoylphorbol Acetate 152-155 H3 histone pseudogene 16 Homo sapiens 4-7 8139548-0 1994 rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor- and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells. Tetradecanoylphorbol Acetate 152-155 H3 histone pseudogene 16 Homo sapiens 65-68 8139548-8 1994 Membrane ruffling was also induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C-activating phorbol ester, but not by Ca2+ ionophore or microinjection of a dominant active Ki-ras p21 mutant (Ki-rasVal-12 p21). Tetradecanoylphorbol Acetate 76-79 H3 histone pseudogene 16 Homo sapiens 199-202 8139548-8 1994 Membrane ruffling was also induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C-activating phorbol ester, but not by Ca2+ ionophore or microinjection of a dominant active Ki-ras p21 mutant (Ki-rasVal-12 p21). Tetradecanoylphorbol Acetate 76-79 H3 histone pseudogene 16 Homo sapiens 224-227 1549353-3 1992 The smg p21 protein molecules also increased during the TPA-induced differentiation of CMK cells. Tetradecanoylphorbol Acetate 56-59 H3 histone pseudogene 16 Homo sapiens 8-11 1549353-5 1992 Ha-ras p21 mRNA was undetectable, but both Ki- and N-ras p21 mRNAs were detected in CMK cells and their levels were also increased during TPA-induced differentiation of CMK cells, although to a lesser extent than those of smg p21 mRNAs. Tetradecanoylphorbol Acetate 138-141 H3 histone pseudogene 16 Homo sapiens 7-10 1549353-5 1992 Ha-ras p21 mRNA was undetectable, but both Ki- and N-ras p21 mRNAs were detected in CMK cells and their levels were also increased during TPA-induced differentiation of CMK cells, although to a lesser extent than those of smg p21 mRNAs. Tetradecanoylphorbol Acetate 138-141 H3 histone pseudogene 16 Homo sapiens 57-60 1549353-5 1992 Ha-ras p21 mRNA was undetectable, but both Ki- and N-ras p21 mRNAs were detected in CMK cells and their levels were also increased during TPA-induced differentiation of CMK cells, although to a lesser extent than those of smg p21 mRNAs. Tetradecanoylphorbol Acetate 138-141 H3 histone pseudogene 16 Homo sapiens 57-60 1549353-9 1992 A dramatic increase in the smg p21 mRNA levels was also observed in other leukemia cell lines during TPA-induced differentiation. Tetradecanoylphorbol Acetate 101-104 H3 histone pseudogene 16 Homo sapiens 31-34 8409414-13 1993 Finally, under conditions in which the PKC inhibitor calphostin C blocks PMA-induced p21ras activation, it does not inhibit Ag-induced p21ras activation. Tetradecanoylphorbol Acetate 73-76 H3 histone pseudogene 16 Homo sapiens 85-88 1779468-9 1991 These findings suggest that smg p21s play an important role during the TPA-induced differentiation of CMK cells. Tetradecanoylphorbol Acetate 71-74 H3 histone pseudogene 16 Homo sapiens 32-35 1939160-3 1991 Activation of p21ras was not observed when the cells were stimulated with the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and pretreatment with TPA for 16 h, sufficient to down-regulate PKC activity, did not abolish p21ras activation by insulin. Tetradecanoylphorbol Acetate 158-161 H3 histone pseudogene 16 Homo sapiens 14-17 22020547-0 2012 TPA-induced p21 expression augments G2/M arrest through a p53-independent mechanism in human breast cancer cells. Tetradecanoylphorbol Acetate 0-3 H3 histone pseudogene 16 Homo sapiens 12-15 32705219-8 2020 Moreover, by using western blot analysis, we determined that EA increased the protein expression of the p53 target proteins p21, p53 upregulated modulator of apoptosis (PUMA) [also known as Bcl-2-binding component 3 (BBC3)] and Phorbol-12-myristate-13-acetate-induced protein 1 (NOXA). Tetradecanoylphorbol Acetate 228-259 H3 histone pseudogene 16 Homo sapiens 124-127 27887857-10 2017 In vitro studies demonstrated that the inhibition of DPP-4 promoted PMA-induced monocytic cells differentiation, with increased CD68 and p21 expression, regulated by extracellular signal-regulated protein kinase 1/2 activation. Tetradecanoylphorbol Acetate 68-71 H3 histone pseudogene 16 Homo sapiens 137-140 22020547-7 2012 Our results showed that the TPA-induced up-regulation of p21 and down-regulation of p53 was reversed by UO126 (a MEK1/2 inhibitor), but not by SP600125 (a JNK inhibitor) or SB203580 (a p38 inhibitor), although TPA increased the phosphorylation of ERK and JNK in MCF-7 cells. Tetradecanoylphorbol Acetate 246-249 H3 histone pseudogene 16 Homo sapiens 69-72 22020547-4 2012 Our results showed that TPA increased the level of p21 expression in MCF-7 cells with wild-type p53 and MDA-MB-231 cells with mutant p53 in a dose-dependent manner. Tetradecanoylphorbol Acetate 24-27 H3 histone pseudogene 16 Homo sapiens 51-54 22020547-11 2012 Taken together, we suggest that TPA reciprocally regulates the level of p21 and p53 expression via a MEK/ERK-dependent pathway. Tetradecanoylphorbol Acetate 44-47 H3 histone pseudogene 16 Homo sapiens 84-87 22020547-12 2012 The up-regulation of p21 in response to TPA is mediated through a p53-independent mechanism in breast cancer cells. Tetradecanoylphorbol Acetate 40-43 H3 histone pseudogene 16 Homo sapiens 21-24 22020547-6 2012 We next examined the regulatory mechanism of TPA on p21 and p53 expression. Tetradecanoylphorbol Acetate 45-48 H3 histone pseudogene 16 Homo sapiens 64-67 22020547-7 2012 Our results showed that the TPA-induced up-regulation of p21 and down-regulation of p53 was reversed by UO126 (a MEK1/2 inhibitor), but not by SP600125 (a JNK inhibitor) or SB203580 (a p38 inhibitor), although TPA increased the phosphorylation of ERK and JNK in MCF-7 cells. Tetradecanoylphorbol Acetate 28-31 H3 histone pseudogene 16 Homo sapiens 69-72 17803520-7 2007 Moreover, incubation with melatonin induces a decrease in p21 expression in these cells that is partially blocked by co-incubation with TPA. Tetradecanoylphorbol Acetate 136-139 H3 histone pseudogene 16 Homo sapiens 58-61 20554189-0 2010 12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells. Tetradecanoylphorbol Acetate 0-37 H3 histone pseudogene 16 Homo sapiens 162-165 20554189-0 2010 12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells. Tetradecanoylphorbol Acetate 39-42 H3 histone pseudogene 16 Homo sapiens 162-165 20554189-7 2010 In contrast, TPA-induced p21 expression was further increased by silibinin. Tetradecanoylphorbol Acetate 13-16 H3 histone pseudogene 16 Homo sapiens 25-28 20554189-10 2010 In addition, TPA-induced down-regulation of cyclin B1 was inhibited by LY294002; however, the basal level of p21 was increased by TPA and TPA-induced p21 expression was further increased by LY294002. Tetradecanoylphorbol Acetate 13-16 H3 histone pseudogene 16 Homo sapiens 109-112 20554189-10 2010 In addition, TPA-induced down-regulation of cyclin B1 was inhibited by LY294002; however, the basal level of p21 was increased by TPA and TPA-induced p21 expression was further increased by LY294002. Tetradecanoylphorbol Acetate 13-16 H3 histone pseudogene 16 Homo sapiens 150-153 20554189-10 2010 In addition, TPA-induced down-regulation of cyclin B1 was inhibited by LY294002; however, the basal level of p21 was increased by TPA and TPA-induced p21 expression was further increased by LY294002. Tetradecanoylphorbol Acetate 130-133 H3 histone pseudogene 16 Homo sapiens 109-112 20554189-10 2010 In addition, TPA-induced down-regulation of cyclin B1 was inhibited by LY294002; however, the basal level of p21 was increased by TPA and TPA-induced p21 expression was further increased by LY294002. Tetradecanoylphorbol Acetate 130-133 H3 histone pseudogene 16 Homo sapiens 109-112 15976015-2 2005 Inhibition of proliferation by TPA in PANC-1 cells was associated with an increase in the level of p21, but this was not observed in MIA PaCa-2 or BxPC-3 cells. Tetradecanoylphorbol Acetate 31-34 H3 histone pseudogene 16 Homo sapiens 99-102 15976015-3 2005 The TPA-induced increase of p21 in PANC-1 cells was blocked by bisindolylmaleimide or rottlerin (inhibitors of protein kinase C). Tetradecanoylphorbol Acetate 4-7 H3 histone pseudogene 16 Homo sapiens 28-31