PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16651411-10	2006	These results show that although both stimuli lead to TFF1 gene activation, estradiol and TPA exert their effects on TFF1 gene expression by different mechanisms.	Tetradecanoylphorbol Acetate	90-93	trefoil factor 1	Homo sapiens	117-121	
16651411-5	2006	Furthermore, whereas both estradiol and TPA increased trefoil factor 1 (TFF1) mRNA levels in these cells, only TPA-induced and not estradiol-induced TFF1 expression was inhibited by the H3 kinase mitogen and stress activated protein kinase (MSK) inhibitor H89 and MAPK kinase inhibitor UO126, showing the involvement of the Ras/MAPK following TPA induction.	Tetradecanoylphorbol Acetate	40-43	trefoil factor 1	Homo sapiens	54-70	
16651411-5	2006	Furthermore, whereas both estradiol and TPA increased trefoil factor 1 (TFF1) mRNA levels in these cells, only TPA-induced and not estradiol-induced TFF1 expression was inhibited by the H3 kinase mitogen and stress activated protein kinase (MSK) inhibitor H89 and MAPK kinase inhibitor UO126, showing the involvement of the Ras/MAPK following TPA induction.	Tetradecanoylphorbol Acetate	40-43	trefoil factor 1	Homo sapiens	72-76	
12021387-3	2002	The phorbol ester phorbol 12-myristate 13-acetate (PMA) stimulated pS2 expression in both HepER3 and the parental, non-ER-expressing HepG2 cells, although its activity was substantially less in HepG2 cells.	Tetradecanoylphorbol Acetate	18-49	trefoil factor 1	Homo sapiens	67-70	
16651411-6	2006	Mutation of the activator protein 1 (AP-1) binding site abrogated the TPA-induced transcriptional response of the luciferase reporter gene under the control of the TFF1 promoter, showing the requirement for the AP-1 site.	Tetradecanoylphorbol Acetate	70-73	trefoil factor 1	Homo sapiens	164-168	
16024613-7	2005	However, whereas treatment of MCF-7 cells with the phorbol ester phorbol-12-myristate 13-acetate also enhances ERRalpha activation of the TFF1 promoter reporter, it does not affect ERRalpha activity on its own promoter.	Tetradecanoylphorbol Acetate	65-96	trefoil factor 1	Homo sapiens	138-142	
15760920-3	2005	They mediated both the phorbol myristate acetate (PMA) downregulation of DMBT1 expression and the initiation of cell differentiation, which was measured by cell cycle withdrawal and the induction of the tissue-specific marker trefoil factor 1 (TFF1).	Tetradecanoylphorbol Acetate	23-48	trefoil factor 1	Homo sapiens	244-248	
15760920-3	2005	They mediated both the phorbol myristate acetate (PMA) downregulation of DMBT1 expression and the initiation of cell differentiation, which was measured by cell cycle withdrawal and the induction of the tissue-specific marker trefoil factor 1 (TFF1).	Tetradecanoylphorbol Acetate	50-53	trefoil factor 1	Homo sapiens	244-248	
12951045-5	2003	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), which directly stimulates protein kinase C (PKC) activity, completely prevented WISP-2 mRNA induction by E2, whereas it increased pS2 mRNA expression more dramatically than maximum stimulation by E2.	Tetradecanoylphorbol Acetate	15-51	trefoil factor 1	Homo sapiens	189-192	
12951045-5	2003	Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), which directly stimulates protein kinase C (PKC) activity, completely prevented WISP-2 mRNA induction by E2, whereas it increased pS2 mRNA expression more dramatically than maximum stimulation by E2.	Tetradecanoylphorbol Acetate	53-56	trefoil factor 1	Homo sapiens	189-192	
12021387-3	2002	The phorbol ester phorbol 12-myristate 13-acetate (PMA) stimulated pS2 expression in both HepER3 and the parental, non-ER-expressing HepG2 cells, although its activity was substantially less in HepG2 cells.	Tetradecanoylphorbol Acetate	51-54	trefoil factor 1	Homo sapiens	67-70	
21533484-4	1997	In MCF-7, pS2-triggered reporter gene expression is greatly enhanced by the tumor promoter TPA, and, to some extend by EGF, demonstrating that pS2 gene expression is due to specific trans-activating factors present in MCF-7, but not in PANG-I or CX-1.	Tetradecanoylphorbol Acetate	91-94	trefoil factor 1	Homo sapiens	10-13	
1911215-7	1991	Rather than preventing transcription of these oestrogen responsive genes, TPA alone increased pNR2 and pNR100 levels in MCF-7 cells and the combined effect of oestradiol and TPA had a marked synergistic effect in increasing the transcript levels of these genes.	Tetradecanoylphorbol Acetate	74-77	trefoil factor 1	Homo sapiens	94-98	
23675462-5	2013	Here, we demonstrate that both MSK1 and MSK2, regulate the phorbol ester 12-O-tetradecanoylphorbol-13-acetate induced expression of the breast cancer marker gene, trefoil factor 1 (TFF1), by phosphorylating H3S10 at its 5" regulatory regions.	Tetradecanoylphorbol Acetate	73-109	trefoil factor 1	Homo sapiens	163-179	
23675462-5	2013	Here, we demonstrate that both MSK1 and MSK2, regulate the phorbol ester 12-O-tetradecanoylphorbol-13-acetate induced expression of the breast cancer marker gene, trefoil factor 1 (TFF1), by phosphorylating H3S10 at its 5" regulatory regions.	Tetradecanoylphorbol Acetate	73-109	trefoil factor 1	Homo sapiens	181-185