PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21303260-3 2011 Topical application of 5 nmol of TPA to mouse ears markedly increased the ear weight, expression of the inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 protein, and phosphorylation of the inhibitor of kappaB (IkappaB) alpha, AKT, and extracellular signal-regulated protein kinase (ERK) 1/2 and reduced IkappaBalpha protein levels. Tetradecanoylphorbol Acetate 33-36 thymoma viral proto-oncogene 1 Mus musculus 243-246 21733825-2 2011 During the process of skin tumor promotion induced by treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), activation of epidermal Akt occurs as well as several downstream effectors of Akt, including the activation of mTORC1. Tetradecanoylphorbol Acetate 125-128 thymoma viral proto-oncogene 1 Mus musculus 155-158 21733825-2 2011 During the process of skin tumor promotion induced by treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), activation of epidermal Akt occurs as well as several downstream effectors of Akt, including the activation of mTORC1. Tetradecanoylphorbol Acetate 125-128 thymoma viral proto-oncogene 1 Mus musculus 209-212 20179211-5 2010 DATS also diminished TPA-induced expression of c-Jun and c-Fos, the principal components of AP-1, and blunted the activation of c-Jun NH(2)-terminal kinase (JNK) and Akt. Tetradecanoylphorbol Acetate 21-24 thymoma viral proto-oncogene 1 Mus musculus 166-169 20660715-8 2010 TPA/capsaicin cotreatment caused EGFR tyrosine phosphorylation and activated EGFR downstream signaling, including ERKs and Akt in EGFR/WT, but not EGFR/KO cells. Tetradecanoylphorbol Acetate 0-3 thymoma viral proto-oncogene 1 Mus musculus 123-126 20336681-6 2010 Moreover, 6-shogaol markedly suppressed TPA-induced activation of extracellular signal-regulate kinase1/2, p38 mitogen-activated protein kinase, JNK1/2, and phosphatidylinositol 3-kinase/Akt, which are upstream of nuclear factor-kappaB and AP-1. Tetradecanoylphorbol Acetate 40-43 thymoma viral proto-oncogene 1 Mus musculus 187-190 20179211-6 2010 Pharmacologic inhibition of JNK or Akt by SP600125 or LY294002, respectively, resulted in diminished AP-1 DNA binding, reduced levels of c-Jun and c-Fos, and inhibition of COX-2 expression in TPA-treated mouse skin. Tetradecanoylphorbol Acetate 192-195 thymoma viral proto-oncogene 1 Mus musculus 35-38 20179211-7 2010 The JNK or Akt kinase assay, taking c-Jun fusion protein as a substrate, revealed that TPA induced JNK- or Akt-mediated c-Jun phosphorylation in mouse skin, which was significantly attenuated by DATS or respective pharmacologic inhibitors. Tetradecanoylphorbol Acetate 87-90 thymoma viral proto-oncogene 1 Mus musculus 11-14 20179211-7 2010 The JNK or Akt kinase assay, taking c-Jun fusion protein as a substrate, revealed that TPA induced JNK- or Akt-mediated c-Jun phosphorylation in mouse skin, which was significantly attenuated by DATS or respective pharmacologic inhibitors. Tetradecanoylphorbol Acetate 87-90 thymoma viral proto-oncogene 1 Mus musculus 107-110 20179211-9 2010 Taken together, the inhibitory effects of DATS on TPA-induced AP-1 activation and COX-2 expression through modulation of JNK or Akt signaling may partly account for its antitumor-promoting effect on mouse skin carcinogenesis. Tetradecanoylphorbol Acetate 50-53 thymoma viral proto-oncogene 1 Mus musculus 128-131 18400024-6 2008 Most PBP fractions decreased TPA-induced cell proliferation by decreasing activation of signalling kinases (c-Jun N-terminal protein kinase, extracellular signal-regulated protein kinase, p38 protein kinase and Akt), transcription factors (activator protein-1 and nuclear factor kappa B) and inflammatory protein (cyclooxygenase 2). Tetradecanoylphorbol Acetate 29-32 thymoma viral proto-oncogene 1 Mus musculus 211-214 19301261-5 2009 The inhibitory effect of Ssd on PMA-induced T cell activation was associated with down-regulation of NF-kappaB signaling through suppression of IKK and Akt activities. Tetradecanoylphorbol Acetate 32-35 thymoma viral proto-oncogene 1 Mus musculus 152-155 18800802-3 2008 TPA was topically applied to the shaven backs of ICR mice with or without CS (1 or 2 mg) for 4 h. The results demonstrated that CS suppressed TPA-induced edema and reduced the expression of cyclooxygenase-2, vascular cell adhesion molecule-1, and Akt signaling in mouse skin. Tetradecanoylphorbol Acetate 0-3 thymoma viral proto-oncogene 1 Mus musculus 247-250 18820286-7 2008 Moreover, DDMN suppressed TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, phosphatidylinositol 3-kinase/Akt and protein kinase C that are upstream of NF-kappaB and activator protien-1. Tetradecanoylphorbol Acetate 26-29 thymoma viral proto-oncogene 1 Mus musculus 163-166 16424000-7 2006 The proapoptotic activity of PKCdelta coupled with its ability to suppress TPA-induced expression of proinflammatory cytokines, COX-2 expression, and the phosphorylation of Akt and p38 may play roles in the suppression of TPA-promoted development of SCC. Tetradecanoylphorbol Acetate 75-78 thymoma viral proto-oncogene 1 Mus musculus 173-176 18171992-12 2007 However, combination of EGFR inhibitor and PKC inhibitor completely abrogated TPA-induced activation of Akt. Tetradecanoylphorbol Acetate 78-81 thymoma viral proto-oncogene 1 Mus musculus 104-107 17962218-6 2007 Moreover, 5-OH-HxMF can suppress TPA-induced activation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt, which are upstream of NF-kappaB. Tetradecanoylphorbol Acetate 33-36 thymoma viral proto-oncogene 1 Mus musculus 173-176 18171992-8 2007 In cultured primary keratinocytes, TPA treatment also led to activation of Akt. Tetradecanoylphorbol Acetate 35-38 thymoma viral proto-oncogene 1 Mus musculus 75-78 18171992-9 2007 Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner. Tetradecanoylphorbol Acetate 92-95 thymoma viral proto-oncogene 1 Mus musculus 108-111 18171992-9 2007 Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner. Tetradecanoylphorbol Acetate 92-95 thymoma viral proto-oncogene 1 Mus musculus 258-261 16950795-6 2007 In addition, 9Z,11E-CLA attenuated TPA-induced phosphorylation of extracellular signal-regulated protein kinase, p38 mitogen-activated protein kinase and Akt. Tetradecanoylphorbol Acetate 35-38 thymoma viral proto-oncogene 1 Mus musculus 154-157 16950795-9 2007 Co-treatment of mouse skin with the IKKbeta-specific inhibitor SC-514 (1 micromol) attenuated TPA-induced activation of Akt and NF-kappaB, and also the expression of COX-2 in hairless mouse skin. Tetradecanoylphorbol Acetate 94-97 thymoma viral proto-oncogene 1 Mus musculus 120-123 16950795-10 2007 Taken together, 9Z,11E-CLA inhibits NF-kappaB driven-COX-2 expression by blocking the IKK and PI3K-Akt signaling in TPA-treated hairless mouse skin in vivo, which may account for its previously reported anti-tumor promoting effects. Tetradecanoylphorbol Acetate 116-119 thymoma viral proto-oncogene 1 Mus musculus 99-102 16338928-7 2006 Selective activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced phospho-Ser-473-Akt, suggesting that activation of PKC inhibits Akt activity. Tetradecanoylphorbol Acetate 31-67 thymoma viral proto-oncogene 1 Mus musculus 98-101 16338928-7 2006 Selective activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced phospho-Ser-473-Akt, suggesting that activation of PKC inhibits Akt activity. Tetradecanoylphorbol Acetate 31-67 thymoma viral proto-oncogene 1 Mus musculus 146-149 16338928-7 2006 Selective activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced phospho-Ser-473-Akt, suggesting that activation of PKC inhibits Akt activity. Tetradecanoylphorbol Acetate 69-72 thymoma viral proto-oncogene 1 Mus musculus 98-101 16338928-7 2006 Selective activation of PKC by 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced phospho-Ser-473-Akt, suggesting that activation of PKC inhibits Akt activity. Tetradecanoylphorbol Acetate 69-72 thymoma viral proto-oncogene 1 Mus musculus 146-149 16338928-8 2006 TPA also attenuated IGF-1 and epidermal growth factor-induced phospho-Ser-473-Akt, reduced Akt kinase activity, and blocked IGF-1 protection from UVC-induced apoptosis. Tetradecanoylphorbol Acetate 0-3 thymoma viral proto-oncogene 1 Mus musculus 78-81 16338928-8 2006 TPA also attenuated IGF-1 and epidermal growth factor-induced phospho-Ser-473-Akt, reduced Akt kinase activity, and blocked IGF-1 protection from UVC-induced apoptosis. Tetradecanoylphorbol Acetate 0-3 thymoma viral proto-oncogene 1 Mus musculus 91-94 16338928-9 2006 The inhibition of Akt activity by TPA was reduced by inhibitors of protein phosphatase 2A, and TPA stimulated the association of phosphatase 2A with Akt. Tetradecanoylphorbol Acetate 34-37 thymoma viral proto-oncogene 1 Mus musculus 18-21 16338928-9 2006 The inhibition of Akt activity by TPA was reduced by inhibitors of protein phosphatase 2A, and TPA stimulated the association of phosphatase 2A with Akt. Tetradecanoylphorbol Acetate 95-98 thymoma viral proto-oncogene 1 Mus musculus 18-21 16338928-9 2006 The inhibition of Akt activity by TPA was reduced by inhibitors of protein phosphatase 2A, and TPA stimulated the association of phosphatase 2A with Akt. Tetradecanoylphorbol Acetate 95-98 thymoma viral proto-oncogene 1 Mus musculus 149-152 16424000-7 2006 The proapoptotic activity of PKCdelta coupled with its ability to suppress TPA-induced expression of proinflammatory cytokines, COX-2 expression, and the phosphorylation of Akt and p38 may play roles in the suppression of TPA-promoted development of SCC. Tetradecanoylphorbol Acetate 222-225 thymoma viral proto-oncogene 1 Mus musculus 173-176 15020199-5 2004 In search for novel markers of skin tumor promotion, we found that TPA application to mouse skin resulted, as an early event, in an increased expression of phosphatidyinositol 3-kinase (PI3K), phosphorylation of Akt at threonine308 and activation of nuclear factor kappa B (NF-kappaB). Tetradecanoylphorbol Acetate 67-70 thymoma viral proto-oncogene 1 Mus musculus 212-215 15122342-9 2004 We found that Lupeol treatment to mouse skin resulted in the inhibition of TPA-induced (i) activation of PI3K, (ii) phosphorylation of Akt at Thr(308), (iii) activation of NF-kappaB and IKKalpha, and (iv) degradation and phosphorylation of IkappaBalpha. Tetradecanoylphorbol Acetate 75-78 thymoma viral proto-oncogene 1 Mus musculus 135-138 15020199-6 2004 Topical application of oleandrin before TPA application to mouse skin resulted in significant reduction in TPA-induced expression of PI3K and phosphorylation of Akt, and inhibition of NF-kappaB activation. Tetradecanoylphorbol Acetate 107-110 thymoma viral proto-oncogene 1 Mus musculus 161-164 35068054-5 2022 Mechanistic analyses suggested that the PPP2CB deletion enhanced activation of the PI3K/Akt signaling pathway and Ca2+ flux following stimulation with PMA plus ionomycin. Tetradecanoylphorbol Acetate 151-154 thymoma viral proto-oncogene 1 Mus musculus 88-91 35068054-0 2022 Protein phosphatase 2A catalytic subunit beta suppresses PMA/ionomycin-induced T-cell activation by negatively regulating PI3K/Akt signaling. Tetradecanoylphorbol Acetate 57-60 thymoma viral proto-oncogene 1 Mus musculus 127-130 31529243-6 2020 Topical DMBA and TPA application resulted in a significant increase in the protein levels, immunoreactivity, and mRNA expression of HRAS, HIF1alpha, Akt, and PTEN (p < 0.05). Tetradecanoylphorbol Acetate 17-20 thymoma viral proto-oncogene 1 Mus musculus 149-152 31327153-5 2019 We show that phorbol 12-myristate 13-acetate (PMA) -activated PKC inhibited Akt activation in neuronal cell, N2a. Tetradecanoylphorbol Acetate 13-44 thymoma viral proto-oncogene 1 Mus musculus 76-79 31327153-5 2019 We show that phorbol 12-myristate 13-acetate (PMA) -activated PKC inhibited Akt activation in neuronal cell, N2a. Tetradecanoylphorbol Acetate 46-49 thymoma viral proto-oncogene 1 Mus musculus 76-79 28322331-6 2017 Western blot analysis showed that both phosphorylated STAT3 and phosphorylated AKT expressions were significantly increased in epidermis of TC-PTP-deficient mice compared to control mice following TPA treatment. Tetradecanoylphorbol Acetate 197-200 thymoma viral proto-oncogene 1 Mus musculus 79-82 30288224-0 2018 Glycyrrhizic acid from licorice down-regulates inflammatory responses via blocking MAPK and PI3K/Akt-dependent NF-kappaB signalling pathways in TPA-induced skin inflammation. Tetradecanoylphorbol Acetate 144-147 thymoma viral proto-oncogene 1 Mus musculus 97-100 26390181-8 2017 Furthermore, Mw strongly suppressed PMA-induced membrane localization of protein kinase C alpha (PKCalpha) since PKCalpha inhibition caused a marked decrease in PMA-induced MMP-9 secretion as well as AKT/ERK-1/2 activation. Tetradecanoylphorbol Acetate 36-39 thymoma viral proto-oncogene 1 Mus musculus 200-203 30288224-6 2018 Moreover, GA significantly inhibited the TPA-mediated activation of extracellular signal-regulated kinase (ERK1/2), p38 mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K)/Akt, which are upstream of nuclear factor-kB (NF-kappaB). Tetradecanoylphorbol Acetate 41-44 thymoma viral proto-oncogene 1 Mus musculus 202-205 28185006-0 2017 Hair follicle stem cell proliferation, Akt and Wnt signaling activation in TPA-induced hair regeneration. Tetradecanoylphorbol Acetate 75-78 thymoma viral proto-oncogene 1 Mus musculus 39-42 28185006-9 2017 Our data indicated that TPA-induced hair follicle regeneration is associated with activation of Akt and Wnt/beta-catenin signaling. Tetradecanoylphorbol Acetate 24-27 thymoma viral proto-oncogene 1 Mus musculus 96-99 25590691-4 2015 Moreover, the active component of CKS, platyconic acid A (PA), suppressed PMA-induced MUC5AC mRNA expression (from 2.1 +- 0.2 to 1.1 +- 0.1) by inhibiting NF-kappaB activation (from 2.3 +- 0.2 to 1.2 +- 0.1) via Akt (from 3.7 +- 0.3 to 2.1 +- 0.2) (p < 0.01) in A549 cells. Tetradecanoylphorbol Acetate 74-77 thymoma viral proto-oncogene 1 Mus musculus 212-215 26438830-4 2015 In murine bone marrow-derived macrophages and murine embryonic fibroblasts stimulated with their cognate growth factors or with phorbol myristate acetate, activation of mTORC1 required an Akt-independent vesicular pathway of amino acid delivery into endolysosomes, mediated by the actin cytoskeleton. Tetradecanoylphorbol Acetate 128-153 thymoma viral proto-oncogene 1 Mus musculus 188-191 26100520-4 2015 The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds. Tetradecanoylphorbol Acetate 56-59 thymoma viral proto-oncogene 1 Mus musculus 116-119 24114993-4 2014 BK5.Akt(WT) transgenic mice, where Akt1 is overexpressed in basal epidermis, are highly sensitive to TPA-induced epidermal proliferation and two-stage skin carcinogenesis. Tetradecanoylphorbol Acetate 101-104 thymoma viral proto-oncogene 1 Mus musculus 4-7 24114993-4 2014 BK5.Akt(WT) transgenic mice, where Akt1 is overexpressed in basal epidermis, are highly sensitive to TPA-induced epidermal proliferation and two-stage skin carcinogenesis. Tetradecanoylphorbol Acetate 101-104 thymoma viral proto-oncogene 1 Mus musculus 35-39 24114993-5 2014 Targeting mTORC1 with rapamycin effectively inhibited TPA-induced epidermal hyperplasia and hyperproliferation as well as tumor promotion in a dose-dependent manner in both wild-type and BK5.Akt(WT) mice. Tetradecanoylphorbol Acetate 54-57 thymoma viral proto-oncogene 1 Mus musculus 191-194 24114993-8 2014 After 2 weeks of TPA treatment, LRCs had moved upward into the interfollicular epidermis from the bulge region of both wild-type and BK5.Akt(WT) mice. Tetradecanoylphorbol Acetate 17-20 thymoma viral proto-oncogene 1 Mus musculus 137-140 22542552-7 2012 Furthermore, piperine significantly inhibited PMA-induced activation of the Akt and ERK. Tetradecanoylphorbol Acetate 46-49 thymoma viral proto-oncogene 1 Mus musculus 76-79 24895206-4 2014 We show that LPS-mediated or TPA-mediated PDCD4 downregulation is catalyzed by the activation of intracellular Akt1 or S6K1 kinases and that sulforaphane suppresses LPS-induced or TPA-induced Akt1 or S6K1 activation, thereby resulting in the attenuation of PDCD4 downregulation in RAW 264.7 cells. Tetradecanoylphorbol Acetate 29-32 thymoma viral proto-oncogene 1 Mus musculus 111-115 24895206-4 2014 We show that LPS-mediated or TPA-mediated PDCD4 downregulation is catalyzed by the activation of intracellular Akt1 or S6K1 kinases and that sulforaphane suppresses LPS-induced or TPA-induced Akt1 or S6K1 activation, thereby resulting in the attenuation of PDCD4 downregulation in RAW 264.7 cells. Tetradecanoylphorbol Acetate 29-32 thymoma viral proto-oncogene 1 Mus musculus 192-196 24258363-4 2014 In addition, the MSE inhibitory effect on upstream of NFkappaB was found to involve the transcriptional effects of MAPK signaling as indicated by strong suppression on TPA-induced activation of extracellular signal regulate kinase (ERK)1/2, p38 mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK)1/2, phosphatidylinositol 3-kinase (PI3K) and Akt. Tetradecanoylphorbol Acetate 168-171 thymoma viral proto-oncogene 1 Mus musculus 361-364 22841871-8 2012 Based on the experiments with specific enzyme inhibitors and phosphospecific antibodies, both PBP-3 and PBP-5 were observed to decrease TPA-induced level and/or activity of phosphatidylinositol 3-kinase (PI3K) and AKT1 (pS473). Tetradecanoylphorbol Acetate 136-139 thymoma viral proto-oncogene 1 Mus musculus 214-218 25027711-6 2014 TPA-induced phosphorylation of Akt, S6 kinase (S6K), and eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) in mouse skin was lower in the curcumin group than in the control group. Tetradecanoylphorbol Acetate 0-3 thymoma viral proto-oncogene 1 Mus musculus 31-34 23429041-7 2013 Furthermore, DHA evidently inhibited PMA-induced phosphorylation of AKT and the MAP Kinases, such as ERK, JNK and p38. Tetradecanoylphorbol Acetate 37-40 thymoma viral proto-oncogene 1 Mus musculus 68-71