PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12023021-4 2002 By prednisolone or phorbol myristate acetate treatment, EC-SOD levels were correlated negatively with levels of IL-6 and IL-8. Tetradecanoylphorbol Acetate 19-44 superoxide dismutase 3 Homo sapiens 56-62 23602908-2 2013 We previously showed the significant reduction or induction of EC-SOD during human monocytic U937 or THP-1 cell differentiation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), respectively; however, its cell-specific expression and regulation have not been fully elucidated. Tetradecanoylphorbol Acetate 139-175 superoxide dismutase 3 Homo sapiens 63-69 23602908-2 2013 We previously showed the significant reduction or induction of EC-SOD during human monocytic U937 or THP-1 cell differentiation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), respectively; however, its cell-specific expression and regulation have not been fully elucidated. Tetradecanoylphorbol Acetate 177-180 superoxide dismutase 3 Homo sapiens 63-69 23602908-5 2013 Moreover, treatment with a DNA methyltransferase inhibitor, 5-azacytidine, significantly induced the expression of EC-SOD in THP-1 cells, indicating the importance of DNA methylation in the suppression of EC-SOD expression; however, the DNA methylation status did not change during THP-1 cell differentiation induced by TPA. Tetradecanoylphorbol Acetate 320-323 superoxide dismutase 3 Homo sapiens 115-121 23602908-7 2013 Further, pretreatment with histone acetyltransferase inhibitors, CPTH2 or garcinol, significantly suppressed the TPA-inducible EC-SOD expression. Tetradecanoylphorbol Acetate 113-116 superoxide dismutase 3 Homo sapiens 127-133 23602908-10 2013 Overall, these findings provide novel evidence that cell-specific and TPA-inducible EC-SOD expression are regulated by DNA methylation and histone H3 and H4 acetylation in human monocytic cells. Tetradecanoylphorbol Acetate 70-73 superoxide dismutase 3 Homo sapiens 84-90 22313459-0 2012 TPA induces the expression of EC-SOD in human monocytic THP-1 cells: involvement of PKC, MEK/ERK and NOX-derived ROS. Tetradecanoylphorbol Acetate 0-3 superoxide dismutase 3 Homo sapiens 30-36 22313459-4 2012 In this study, we investigated the expression of EC-SOD during 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced monocytic differentiation of THP-1 cells, which is not expressing its gene in the basal phase. Tetradecanoylphorbol Acetate 63-99 superoxide dismutase 3 Homo sapiens 49-55 22313459-4 2012 In this study, we investigated the expression of EC-SOD during 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced monocytic differentiation of THP-1 cells, which is not expressing its gene in the basal phase. Tetradecanoylphorbol Acetate 101-104 superoxide dismutase 3 Homo sapiens 49-55 22313459-5 2012 We confirmed the significant induction of EC-SOD in a TPA time-dependent manner, and that induction was completely blocked by pre-treatment with GF109203X, an inhibitor of protein kinase C, U0126 and PD98059, inhibitors of mitogen-activated protein kinase kinase/extracellular-signal regulated kinase. Tetradecanoylphorbol Acetate 54-57 superoxide dismutase 3 Homo sapiens 42-48 21077177-4 2011 Recently, the reduction of Cu/Zn-SOD and the induction of Mn-SOD by TPA in leukemic cells have been reported; however, the regulation of EC-SOD by TPA remains poorly understood. Tetradecanoylphorbol Acetate 147-150 superoxide dismutase 3 Homo sapiens 137-143 21077177-5 2011 Here, we explored the regulation of EC-SOD during the monocytic differentiation of U937 cells by TPA. Tetradecanoylphorbol Acetate 97-100 superoxide dismutase 3 Homo sapiens 36-42 21077177-10 2011 Overall, our results suggest that the expression of EC-SOD is decreased by TPA through intracellular signaling consisting of PKC, NOX-derived ROS and MEK/ERK, but not of NF-kappaB signaling. Tetradecanoylphorbol Acetate 75-78 superoxide dismutase 3 Homo sapiens 52-58 35271779-8 2022 Additionally, it was first determined that the knockdown of the transcription factor forkhead box O1 (FOXO1) significantly suppressed TPA-elicited SOD3 induction. Tetradecanoylphorbol Acetate 134-137 superoxide dismutase 3 Homo sapiens 147-151 29842805-6 2018 The present results showed that the MEF2A and MEF2D function as mediators for TPA-elicited SOD3 expression by interacting with HDAC or p300. Tetradecanoylphorbol Acetate 78-81 superoxide dismutase 3 Homo sapiens 91-95 29842805-2 2018 We previously demonstrated that histone acetylation is involved in 12-O-tetra-decanoylphorbol-13-acetate (TPA)-elicited SOD3 expression in human monocytic THP-1 cells; however, the molecular mechanisms responsible for its expression have not yet been elucidated in detail. Tetradecanoylphorbol Acetate 106-109 superoxide dismutase 3 Homo sapiens 120-124 29842805-4 2018 On the other hand, the dissociation of HDAC1 from the SOD3 promoter region and the enrichment of p300, a histone acetyltransferase (HAT), within that region were observed in TPA-induced THP-1 cells. Tetradecanoylphorbol Acetate 174-177 superoxide dismutase 3 Homo sapiens 54-58 29168020-5 2018 Furthermore, Atox-1 bound to the SOD3 promoter region in TPA-treated THP-1 cells. Tetradecanoylphorbol Acetate 57-60 superoxide dismutase 3 Homo sapiens 33-37 29168020-6 2018 The overexpression of Atox-1 in THP-1 cells significantly enhanced TPA-elicited SOD3 expression, whereas its knockdown suppressed this induction. Tetradecanoylphorbol Acetate 67-70 superoxide dismutase 3 Homo sapiens 80-84 29168020-7 2018 The present results demonstrate that Atox-1 functions as a key molecule in TPA-elicited SOD3 expression. Tetradecanoylphorbol Acetate 75-78 superoxide dismutase 3 Homo sapiens 88-92