PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26428848-4 2015 It is possible that U73122 blocked PMA-induced adhesion of U937 cells partially by down regulation and inactivation of both Pyk2 and paxillin signaling. Tetradecanoylphorbol Acetate 35-38 protein tyrosine kinase 2 beta Homo sapiens 124-128 18198130-0 2008 Induction of proline-rich tyrosine kinase2 (Pyk2) through C/EBPbeta is involved in PMA-induced monocyte differentiation. Tetradecanoylphorbol Acetate 83-86 protein tyrosine kinase 2 beta Homo sapiens 13-42 23690212-1 2013 TPA (12-O-tetradecanoylphorbol-1, 3-acetate) can induce cell apoptosis and cause PKB (protein kinase B) degradation correlated with its phosphorylation in gastric cancer cells. Tetradecanoylphorbol Acetate 0-3 protein tyrosine kinase 2 beta Homo sapiens 81-84 23690212-1 2013 TPA (12-O-tetradecanoylphorbol-1, 3-acetate) can induce cell apoptosis and cause PKB (protein kinase B) degradation correlated with its phosphorylation in gastric cancer cells. Tetradecanoylphorbol Acetate 0-3 protein tyrosine kinase 2 beta Homo sapiens 86-102 23690212-4 2013 Moreover, MG132 (26S proteasome inhibitor) partially inhibited TPA-induced degradation of PKB. Tetradecanoylphorbol Acetate 63-66 protein tyrosine kinase 2 beta Homo sapiens 90-93 23690212-5 2013 Taken together, TPA could degrade PKB via the ubiquitin-proteasomal pathway, and the suppression of PKB phosphorylation at the serine 473 site might be a prerequisite for the TPA-induced ubiquitination in gastric cancer cells. Tetradecanoylphorbol Acetate 16-19 protein tyrosine kinase 2 beta Homo sapiens 34-37 23690212-5 2013 Taken together, TPA could degrade PKB via the ubiquitin-proteasomal pathway, and the suppression of PKB phosphorylation at the serine 473 site might be a prerequisite for the TPA-induced ubiquitination in gastric cancer cells. Tetradecanoylphorbol Acetate 175-178 protein tyrosine kinase 2 beta Homo sapiens 100-103 18198130-0 2008 Induction of proline-rich tyrosine kinase2 (Pyk2) through C/EBPbeta is involved in PMA-induced monocyte differentiation. Tetradecanoylphorbol Acetate 83-86 protein tyrosine kinase 2 beta Homo sapiens 44-48 12730223-6 2003 The protein kinase C (PKC) activator phorbol 12-myristate 13-acetate stimulated PYK2 phosphorylation and MMP-13 production. Tetradecanoylphorbol Acetate 37-68 protein tyrosine kinase 2 beta Homo sapiens 80-84 17205062-6 2007 Pyk2 is activated by treatment with keratinocyte-differentiating agents, 12-O-tetradecanoylphorbol-13-acetate and calcium via a mechanism that requires intracellular calcium release and functional protein kinase C (PKC) and Src activities. Tetradecanoylphorbol Acetate 73-109 protein tyrosine kinase 2 beta Homo sapiens 0-4 11809859-4 2002 In C9 cells, phorbol-12-myristate-13-acetate (PMA) caused much greater phosphorylation of Pyk2 and ERK than the Ca(2+) ionophore ionomycin, and the effects of PMA and Ang II were abolished in PKC-depleted cells. Tetradecanoylphorbol Acetate 13-44 protein tyrosine kinase 2 beta Homo sapiens 90-94 12388064-4 2003 Treatment of cells with PMA or L-PGDS decreased phosphatidylinositol 3-kinase (PI3-K) activity and concomitantly inhibited protein kinase B (PKB/Akt) phosphorylation, which led to the hypophosphorylation and activation of Bad. Tetradecanoylphorbol Acetate 24-27 protein tyrosine kinase 2 beta Homo sapiens 123-139 12400610-6 2002 Evidence that RAFTK is a modulator of Akt came from phorbol myristic acetate (PMA) stimulation. Tetradecanoylphorbol Acetate 78-81 protein tyrosine kinase 2 beta Homo sapiens 14-19 11809859-4 2002 In C9 cells, phorbol-12-myristate-13-acetate (PMA) caused much greater phosphorylation of Pyk2 and ERK than the Ca(2+) ionophore ionomycin, and the effects of PMA and Ang II were abolished in PKC-depleted cells. Tetradecanoylphorbol Acetate 46-49 protein tyrosine kinase 2 beta Homo sapiens 90-94 9844925-5 1998 Here, we show that the PMA-induced phenotypic changes of K562 cells such as polylobulation of the nucleus and Pyk2 expression are independent of MAPK activation. Tetradecanoylphorbol Acetate 23-26 protein tyrosine kinase 2 beta Homo sapiens 110-114 10749687-7 2000 Furthermore, PMA-induced Pyk2 (and FAK) tyrosine phosphorylation was also observed when platelets adhered to immobilized fibrinogen. Tetradecanoylphorbol Acetate 13-16 protein tyrosine kinase 2 beta Homo sapiens 25-29 10625683-9 2000 The involvement of protein tyrosine phosphatases (PTPases) in mediating the dephosphorylation of the focal adhesion PTKs was confirmed by the failure of PMA to dephosphorylate Pyk2 in cells pretreated with the PTPase inhibitor orthovanadate. Tetradecanoylphorbol Acetate 153-156 protein tyrosine kinase 2 beta Homo sapiens 176-180 9545257-7 1998 In contrast, monocyte adherence to tissue culture plastic-stimulated CADTK tyrosine phosphorylation, a process that was enhanced by thapsigargin, phorbol 12-myristate 13-acetate, and RANTES but that was completely blocked by preincubation with cytochalasin D. Tetradecanoylphorbol Acetate 146-177 protein tyrosine kinase 2 beta Homo sapiens 69-74 9177393-5 1997 The c-jun and c-fos mRNA stimulation elicited by TPA was reduced by the PKC inhibitors, chelerythrine and staurosporine, and could not be mimicked by 4alpha-phorbol 12,13-didecanoate (a phorbol ester that fails to activate PKC), whereas the stimulation induced by EGF was diminished by the PTK inhibitor, genistein. Tetradecanoylphorbol Acetate 49-52 protein tyrosine kinase 2 beta Homo sapiens 290-293 8558060-7 1996 Protein kinase C (PKC) and protein tyrosine kinase (PTK) inhibition essentially abolished both PMA-induced TNF-alpha protein secretion and collagenase mRNA expression. Tetradecanoylphorbol Acetate 95-98 protein tyrosine kinase 2 beta Homo sapiens 52-55 9177393-6 1997 This indicates a PKC- and PTK-mediated pathway triggered by TPA and EGF, respectively. Tetradecanoylphorbol Acetate 60-63 protein tyrosine kinase 2 beta Homo sapiens 26-29 9099734-2 1997 Stem cell factor, which potentiates the growth of megakaryocytes and their progenitors, and phorbol myristate acetate, which causes differentiation of megakaryocytic cell lines, induced the tyrosine phosphorylation of RAFTK but not of focal adhesion kinase. Tetradecanoylphorbol Acetate 92-117 protein tyrosine kinase 2 beta Homo sapiens 218-223 9099734-5 1997 Cytochalasin D, which disrupts the cytoskeleton, abolished the phosphorylation of RAFTK upon phorbol myristate acetate and stem cell factor stimulation, indicating that RAFTK association with the actin cytoskeleton appears to be critical for its phosphorylation. Tetradecanoylphorbol Acetate 93-118 protein tyrosine kinase 2 beta Homo sapiens 82-87 9099734-5 1997 Cytochalasin D, which disrupts the cytoskeleton, abolished the phosphorylation of RAFTK upon phorbol myristate acetate and stem cell factor stimulation, indicating that RAFTK association with the actin cytoskeleton appears to be critical for its phosphorylation. Tetradecanoylphorbol Acetate 93-118 protein tyrosine kinase 2 beta Homo sapiens 169-174 9099734-8 1997 Transient overexpression of a dominant-negative mutant of RAFTK inhibited significantly the tyrosine phosphorylation of paxillin upon phorbol myristate acetate stimulation. Tetradecanoylphorbol Acetate 134-159 protein tyrosine kinase 2 beta Homo sapiens 58-63 9099734-0 1997 Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin. Tetradecanoylphorbol Acetate 115-140 protein tyrosine kinase 2 beta Homo sapiens 32-70 7545319-4 1995 As it has been established that LPS and PMA activate protein tyrosine kinase (PTK) in monocytes, we studied the role of PTK in LPS and PMA induction of TF by human blood monocytes. Tetradecanoylphorbol Acetate 40-43 protein tyrosine kinase 2 beta Homo sapiens 78-81