PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9822802-7	1998	Incubation with a cAMP analogue (8-bromo-cAMP, 8Br-cAMP) or with a PKC activator (12-O-tetradecanoylphorbol-13-acetate, TPA) increased TRH mRNA levels after 1 and 2 h, respectively.	Tetradecanoylphorbol Acetate	82-118	thyrotropin releasing hormone	Homo sapiens	135-138	
9822802-10	1998	The stimulatory effect of 10(-7) M TPA on TRH mRNA levels was additive to that of dexamethasone; in contrast, coincubation with 10(-3) M 8-Br-cAMP and dexamethasone diminished the stimulatory effect of both drugs.	Tetradecanoylphorbol Acetate	35-38	thyrotropin releasing hormone	Homo sapiens	42-45	
9706014-10	1998	The effects of TRH were mimicked by direct pharmacological activation of protein kinase C (PKC) with beta-phorbol 12-myristate, 13-acetate (PMA).	Tetradecanoylphorbol Acetate	140-143	thyrotropin releasing hormone	Homo sapiens	15-18	
8596491-6	1996	These results suggest that TPA, an activator of PKC, has a stimulatory effect on GRH-induced cAMP production and that, finally, TRH- and CRH-induced PKC activation may cause greater secretion of GH by enhancement of cAMP production in human GH-hypersecreting adenoma cells.	Tetradecanoylphorbol Acetate	27-30	thyrotropin releasing hormone	Homo sapiens	128-131	
7969791-6	1994	Phorbol-12-myristate-13-acetate (PMA; 10(-6) M), a protein kinase C (PKC) activator, diminished PPII activity to 61% or initial values with an ED50 of 2.2 x 10(-8) M. Maximal effects of PMA and TRH were not additive.	Tetradecanoylphorbol Acetate	0-31	thyrotropin releasing hormone	Homo sapiens	194-197	
7969791-6	1994	Phorbol-12-myristate-13-acetate (PMA; 10(-6) M), a protein kinase C (PKC) activator, diminished PPII activity to 61% or initial values with an ED50 of 2.2 x 10(-8) M. Maximal effects of PMA and TRH were not additive.	Tetradecanoylphorbol Acetate	33-36	thyrotropin releasing hormone	Homo sapiens	194-197	
8183247-5	1994	Expression in several cell lines in culture reveals that rapid TRH-R desensitization by TRH and phorbol 12-myristate 13-acetate is cell type specific.	Tetradecanoylphorbol Acetate	96-127	thyrotropin releasing hormone	Homo sapiens	63-66	
2826275-7	1987	PMA had no effect on basal phosphoinositide or inositol phosphate levels, but attenuated the effects of TRH on these parameters.	Tetradecanoylphorbol Acetate	0-3	thyrotropin releasing hormone	Homo sapiens	104-107