PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20627998-6 2010 Pretreatment with E6201 cream attenuated phorbol-12 myristate 13-acetate-induced ornithine decarboxylase activity, a marker of proliferation in epidermis. Tetradecanoylphorbol Acetate 41-72 ornithine decarboxylase, structural 1 Mus musculus 81-104 29115558-8 2018 The activity of ornithine decarboxylase, increased by TPA, was additionally inhibited following pretreatment of the mice with bryostatin 1. Tetradecanoylphorbol Acetate 54-57 ornithine decarboxylase, structural 1 Mus musculus 16-39 22986104-3 2012 TPA induced the expression of critical events of tumorigenesis like ornithine decarboxylase, cyclooxygenase-2, interleukin-6 and pSTAT3 in mouse skin after 5h of application, whereas expression of transglutaminase2 was decreased at this time point. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 68-91 19470390-7 2009 Pretreatment of farnesol significantly decreased TPA-induced ornithine decarboxylase (ODC) activity and [(3)H]thymidine incorporation in dose-dependent manner. Tetradecanoylphorbol Acetate 49-52 ornithine decarboxylase, structural 1 Mus musculus 61-84 19470390-7 2009 Pretreatment of farnesol significantly decreased TPA-induced ornithine decarboxylase (ODC) activity and [(3)H]thymidine incorporation in dose-dependent manner. Tetradecanoylphorbol Acetate 49-52 ornithine decarboxylase, structural 1 Mus musculus 86-89 18820286-3 2008 We demonstrated that topical application of DDMN effectively inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated transcription of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and ornithine decarboxylase (ODC) messenger RNA and protein expression in mouse skin. Tetradecanoylphorbol Acetate 71-107 ornithine decarboxylase, structural 1 Mus musculus 209-232 18820286-3 2008 We demonstrated that topical application of DDMN effectively inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated transcription of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and ornithine decarboxylase (ODC) messenger RNA and protein expression in mouse skin. Tetradecanoylphorbol Acetate 71-107 ornithine decarboxylase, structural 1 Mus musculus 234-237 18820286-3 2008 We demonstrated that topical application of DDMN effectively inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated transcription of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and ornithine decarboxylase (ODC) messenger RNA and protein expression in mouse skin. Tetradecanoylphorbol Acetate 109-112 ornithine decarboxylase, structural 1 Mus musculus 209-232 18820286-3 2008 We demonstrated that topical application of DDMN effectively inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated transcription of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and ornithine decarboxylase (ODC) messenger RNA and protein expression in mouse skin. Tetradecanoylphorbol Acetate 109-112 ornithine decarboxylase, structural 1 Mus musculus 234-237 17234720-0 2007 Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-kappa B. Tetradecanoylphorbol Acetate 23-59 ornithine decarboxylase, structural 1 Mus musculus 157-180 18534633-0 2008 Hemin inhibits cyclooxygenase-2 expression through nuclear factor-kappa B activation and ornithine decarboxylase expression in 12-O-tetradecanoylphorbol-13-acetate-treated mouse skin. Tetradecanoylphorbol Acetate 127-163 ornithine decarboxylase, structural 1 Mus musculus 89-112 17583568-8 2007 The TPA resistance phenotype correlated with a reduced ability to induce ornithine decarboxylase, interleukin-1alpha, and tumor necrosis factor-alpha and a reduced proliferation response. Tetradecanoylphorbol Acetate 4-7 ornithine decarboxylase, structural 1 Mus musculus 73-96 18534633-9 2008 Taken together, hemin inhibited TPA-induced COX-2 expression by altering NF-kappaB signaling pathway via ERK and p38 MAPK, as well as TPA-induced ODC expression in mouse skin. Tetradecanoylphorbol Acetate 134-137 ornithine decarboxylase, structural 1 Mus musculus 146-149 17234720-5 2007 To further elucidate the molecular mechanisms underlying the antitumor-promoting activity of xanthorrhizol, its effect on the TPA-induced expression of ornithine decarboxylase (ODC), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the upstream signaling molecules controlling these proteins were explored in mouse skin. Tetradecanoylphorbol Acetate 126-129 ornithine decarboxylase, structural 1 Mus musculus 152-175 17234720-5 2007 To further elucidate the molecular mechanisms underlying the antitumor-promoting activity of xanthorrhizol, its effect on the TPA-induced expression of ornithine decarboxylase (ODC), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the upstream signaling molecules controlling these proteins were explored in mouse skin. Tetradecanoylphorbol Acetate 126-129 ornithine decarboxylase, structural 1 Mus musculus 177-180 17234720-7 2007 When mouse skin was treated after TPA-induced production of papillomas, xanthorrhizol remarkably suppressed the expression of ODC, iNOS and COX-2 and inhibited the activation of NF-kappaB. Tetradecanoylphorbol Acetate 34-37 ornithine decarboxylase, structural 1 Mus musculus 126-129 15501252-8 2004 Topical application of curcumin, 10, 13, 21, and 6, a methoxy derivative of curcumin, showed strong inhibition of 12-O-tetradecanoyl-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in mouse skin. Tetradecanoylphorbol Acetate 145-148 ornithine decarboxylase, structural 1 Mus musculus 158-181 17674818-4 2007 The induction of inflammation in skin mediated by TPA is believed to be governed by cyclooxygenase (COX), lipoxygenase and ornithine decarboxylase (ODC). Tetradecanoylphorbol Acetate 50-53 ornithine decarboxylase, structural 1 Mus musculus 123-146 17674818-4 2007 The induction of inflammation in skin mediated by TPA is believed to be governed by cyclooxygenase (COX), lipoxygenase and ornithine decarboxylase (ODC). Tetradecanoylphorbol Acetate 50-53 ornithine decarboxylase, structural 1 Mus musculus 148-151 17674818-8 2007 TPA treatment also enhanced ODC activity and [3H] thymidine incorporation into cutaneous DNA. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 28-31 15993536-5 2006 Separately, SF inhibited TPA-induced ornithine decarboxylase activity in mouse skin, an obligate step in TPA-induced promotion of carcinogenesis. Tetradecanoylphorbol Acetate 25-28 ornithine decarboxylase, structural 1 Mus musculus 37-60 15993536-5 2006 Separately, SF inhibited TPA-induced ornithine decarboxylase activity in mouse skin, an obligate step in TPA-induced promotion of carcinogenesis. Tetradecanoylphorbol Acetate 105-108 ornithine decarboxylase, structural 1 Mus musculus 37-60 16156954-4 2005 Topical application of TPA alone in mouse skin enhances ornithine decarboxylase activity and also increases [3H]-thymidine incorporation in DNA. Tetradecanoylphorbol Acetate 23-26 ornithine decarboxylase, structural 1 Mus musculus 56-79 16969515-7 2006 Furthermore, it showed that AT inhibited the TPA-induced expression of COX-2 protein and ornithine decarboxylase (ODC) activity in epidermis. Tetradecanoylphorbol Acetate 45-48 ornithine decarboxylase, structural 1 Mus musculus 89-112 16969515-7 2006 Furthermore, it showed that AT inhibited the TPA-induced expression of COX-2 protein and ornithine decarboxylase (ODC) activity in epidermis. Tetradecanoylphorbol Acetate 45-48 ornithine decarboxylase, structural 1 Mus musculus 114-117 16175052-5 2005 alpha-Santalol treatment (1.25% and 2.5%) resulted in a significant decrease in the TPA-induced ODC activity and incorporation of [3H]thymidine in DNA in the epidermis of CD-1 mice. Tetradecanoylphorbol Acetate 84-87 ornithine decarboxylase, structural 1 Mus musculus 96-99 15734996-4 2005 Compared with Odc(+/+) mice, Odc(+/-) mice exhibit reduced epidermal ODC enzyme activity and polyamine accumulation following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 160-196 ornithine decarboxylase, structural 1 Mus musculus 29-32 15734996-4 2005 Compared with Odc(+/+) mice, Odc(+/-) mice exhibit reduced epidermal ODC enzyme activity and polyamine accumulation following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 160-196 ornithine decarboxylase, structural 1 Mus musculus 69-72 15734996-4 2005 Compared with Odc(+/+) mice, Odc(+/-) mice exhibit reduced epidermal ODC enzyme activity and polyamine accumulation following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 198-201 ornithine decarboxylase, structural 1 Mus musculus 29-32 15734996-5 2005 Furthermore, following chronic TPA treatment, the characteristic hyperplastic response of the epidermis was diminished in Odc(+/-) mice. Tetradecanoylphorbol Acetate 31-34 ornithine decarboxylase, structural 1 Mus musculus 122-125 15498788-13 2005 When IH-901 was treated topically prior to TPA, expression and activity of ODC were inhibited dose-dependently. Tetradecanoylphorbol Acetate 43-46 ornithine decarboxylase, structural 1 Mus musculus 75-78 15501252-8 2004 Topical application of curcumin, 10, 13, 21, and 6, a methoxy derivative of curcumin, showed strong inhibition of 12-O-tetradecanoyl-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in mouse skin. Tetradecanoylphorbol Acetate 145-148 ornithine decarboxylase, structural 1 Mus musculus 183-186 15354318-4 2004 However, the ornithine decarboxylase (ODC) activity and unscheduled DNA synthesis are elevated on single topical application of TPA to the dorsal cutaneous portions of the mice. Tetradecanoylphorbol Acetate 128-131 ornithine decarboxylase, structural 1 Mus musculus 13-36 15354318-4 2004 However, the ornithine decarboxylase (ODC) activity and unscheduled DNA synthesis are elevated on single topical application of TPA to the dorsal cutaneous portions of the mice. Tetradecanoylphorbol Acetate 128-131 ornithine decarboxylase, structural 1 Mus musculus 38-41 15354318-5 2004 Topical applications of soy isoflavones, half-an-hour prior to the application of TPA prevented the induction of ODC activity and DNA synthesis mediated by TPA (p < 0.01). Tetradecanoylphorbol Acetate 82-85 ornithine decarboxylase, structural 1 Mus musculus 113-116 15354318-5 2004 Topical applications of soy isoflavones, half-an-hour prior to the application of TPA prevented the induction of ODC activity and DNA synthesis mediated by TPA (p < 0.01). Tetradecanoylphorbol Acetate 156-159 ornithine decarboxylase, structural 1 Mus musculus 113-116 14997284-12 2004 ornithine decarboxylase activity and [(3)H]thymidine incorporation into cutaneous DNA, was about 60% lower in TPA-treated mice fed on low iron diet than in normal mice treated with TPA. Tetradecanoylphorbol Acetate 110-113 ornithine decarboxylase, structural 1 Mus musculus 0-23 14997284-12 2004 ornithine decarboxylase activity and [(3)H]thymidine incorporation into cutaneous DNA, was about 60% lower in TPA-treated mice fed on low iron diet than in normal mice treated with TPA. Tetradecanoylphorbol Acetate 181-184 ornithine decarboxylase, structural 1 Mus musculus 0-23 12757023-7 2003 One of the mechanisms by which retinoids inhibit promotion of mouse skin tumor formation involves their property to inhibit the induction of ornithine decarboxylase by the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Tetradecanoylphorbol Acetate 201-237 ornithine decarboxylase, structural 1 Mus musculus 141-164 14585180-6 2003 In a second experiment, two groups each consisting of three CD(1) mice were used to assess the effect of pomegranate seed oil on TPA-stimulated ornithine decarboxylase (ODC) activity, an important event in skin cancer promotion. Tetradecanoylphorbol Acetate 129-132 ornithine decarboxylase, structural 1 Mus musculus 169-172 14585180-10 2003 Pomegranate seed oil (5%) significantly decreased (P <.05) tumor incidence, multiplicity, and TPA-induced ODC activity. Tetradecanoylphorbol Acetate 97-100 ornithine decarboxylase, structural 1 Mus musculus 109-112 12628505-5 2003 Pretreatment of dorsal skins of female ICR mice with Rg(3) significantly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase activity and 7,12-dimethylbenz[a]anthracene-initiated papilloma formation. Tetradecanoylphorbol Acetate 83-119 ornithine decarboxylase, structural 1 Mus musculus 134-157 14644357-9 2003 Furthermore, CHL, hemin and TBAP decreased myeloperoxidase (MPO) activity and H(2)O(2) formation as well as epidermal ornithine decarboxylase (ODC) activity in mouse skin treated with TPA. Tetradecanoylphorbol Acetate 184-187 ornithine decarboxylase, structural 1 Mus musculus 118-141 14644357-9 2003 Furthermore, CHL, hemin and TBAP decreased myeloperoxidase (MPO) activity and H(2)O(2) formation as well as epidermal ornithine decarboxylase (ODC) activity in mouse skin treated with TPA. Tetradecanoylphorbol Acetate 184-187 ornithine decarboxylase, structural 1 Mus musculus 143-146 12810623-2 2003 TPA treatment induced epidermal ornithine decarboxylase (ODC) activity and putrescine levels approximately 3-4-fold more in PKC epsilon transgenic mice than their wild-type littermates. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 32-55 12810623-2 2003 TPA treatment induced epidermal ornithine decarboxylase (ODC) activity and putrescine levels approximately 3-4-fold more in PKC epsilon transgenic mice than their wild-type littermates. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 57-60 12810623-6 2003 These results indicate that TPA-induced ODC activity and the resultant accumulation of putrescine in PKC epsilon transgenic mice are linked to growth and maintenance of hair follicles, and the development of mSCC. Tetradecanoylphorbol Acetate 28-31 ornithine decarboxylase, structural 1 Mus musculus 40-43 12668279-7 2003 Since TPA-induced epidermal ornithine decarboxylase (ODC) activity and [(3)H]thymidine incorporation are conventionally used markers of skin tumor promotion, we also assessed the effect of pre-application of palm oil on these parameters, and it was observed that the application of palm oil prior to the application of TPA alleviated both these TPA-induced markers of tumor promotion. Tetradecanoylphorbol Acetate 6-9 ornithine decarboxylase, structural 1 Mus musculus 28-51 12668279-7 2003 Since TPA-induced epidermal ornithine decarboxylase (ODC) activity and [(3)H]thymidine incorporation are conventionally used markers of skin tumor promotion, we also assessed the effect of pre-application of palm oil on these parameters, and it was observed that the application of palm oil prior to the application of TPA alleviated both these TPA-induced markers of tumor promotion. Tetradecanoylphorbol Acetate 6-9 ornithine decarboxylase, structural 1 Mus musculus 53-56 12582025-6 2003 The effects of alpha-santalol treatment on TPA-induced epidermal ornithine decarboxylase (ODC) activity and (3)H-thymidine incorporation in epidermal DNA of CD-1 and SENCAR mice were also investigated. Tetradecanoylphorbol Acetate 43-46 ornithine decarboxylase, structural 1 Mus musculus 65-88 12582025-6 2003 The effects of alpha-santalol treatment on TPA-induced epidermal ornithine decarboxylase (ODC) activity and (3)H-thymidine incorporation in epidermal DNA of CD-1 and SENCAR mice were also investigated. Tetradecanoylphorbol Acetate 43-46 ornithine decarboxylase, structural 1 Mus musculus 90-93 12582025-9 2003 alpha-Santalol treatment resulted in a significant (P < 0.05) inhibition in TPA-induced ODC activity and incorporation of (3)H-thymidine in DNA in the epidermis of both strains of mice. Tetradecanoylphorbol Acetate 79-82 ornithine decarboxylase, structural 1 Mus musculus 91-94 12065085-11 2002 TPA was the most effective in inducing epidermal ODC activity and [(3)H]thymidine incorporation followed by mezerein, COOH and BPO. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 49-52 12209884-3 2002 TPA-induced mitogen activated protein kinases (MAPK) phosphorylation, ornithine decarboxylase (ODC), c-Jun, and cyclooxygenase 2 (COX-2) protein expressions in a time-dependent manner, and the maximal inductive time point is at 1 h for MAPK phosphorylation and 6 h for others. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 70-93 12209884-3 2002 TPA-induced mitogen activated protein kinases (MAPK) phosphorylation, ornithine decarboxylase (ODC), c-Jun, and cyclooxygenase 2 (COX-2) protein expressions in a time-dependent manner, and the maximal inductive time point is at 1 h for MAPK phosphorylation and 6 h for others. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 95-98 12209884-4 2002 Flavanone, 2"-OH flavanone, 4"-OH flavanone, 6-OH flavanone showed the dose-dependent inhibition on TPA-stimulated MAPK phosphorylation, COX-2, ODC, c-Jun protein expressions. Tetradecanoylphorbol Acetate 100-103 ornithine decarboxylase, structural 1 Mus musculus 144-147 12209884-7 2002 And, PD98059, a specific inhibitor of ERKs, inhibited TPA-induced MAPK phosphorylation, accompanied by decreasing COX-2, c-Jun, and ODC protein expression, and showed dose-dependent inhibition on TPA-induced proliferation in cells. Tetradecanoylphorbol Acetate 54-57 ornithine decarboxylase, structural 1 Mus musculus 132-135 12209884-8 2002 These results demonstrated that PGE(2) is an important mediator in TPA-induced proliferation, and MAPK phosphorylation was located at the upstream of COX-2, c-Jun, and ODC gene expressions in TPA-induced responses. Tetradecanoylphorbol Acetate 192-195 ornithine decarboxylase, structural 1 Mus musculus 168-171 12209884-9 2002 Furthermore, flavanone, 2"-OH flavanone, 4"-OH flavanone, 6-OH flavanone (100 microM) suppressed TPA-induced colony formation associated with blocking MAPK phosphorylation, ODC, c-Jun, and COX-2 proteins expression. Tetradecanoylphorbol Acetate 97-100 ornithine decarboxylase, structural 1 Mus musculus 173-176 12032864-5 2002 To determine if TPA-induced ODC activity and associated putrescine levels in PKCdelta transgenic mice contributed to PKCdelta-mediated suppression of skin tumor promotion by TPA, the irreversible inhibitor of ODC, alpha-difluoromethylornithine (DFMO), was used. Tetradecanoylphorbol Acetate 16-19 ornithine decarboxylase, structural 1 Mus musculus 209-212 12032864-3 2002 However, despite being resistant to skin tumor promotion by TPA, PKCdelta transgenic mice elicited a 3-4-fold increase in TPA-induced epidermal ODC activity and putrescine levels than their wild-type littermates. Tetradecanoylphorbol Acetate 122-125 ornithine decarboxylase, structural 1 Mus musculus 144-147 11853175-6 2002 And it also suppressed ornithine decarboxylase activity stimulated by TPA on mouse skin. Tetradecanoylphorbol Acetate 70-73 ornithine decarboxylase, structural 1 Mus musculus 23-46 12032864-4 2002 PKCdelta was observed to be the key component of the TPA signal transduction pathways to the induction of mouse epidermal ODC activity. Tetradecanoylphorbol Acetate 53-56 ornithine decarboxylase, structural 1 Mus musculus 122-125 12032864-5 2002 To determine if TPA-induced ODC activity and associated putrescine levels in PKCdelta transgenic mice contributed to PKCdelta-mediated suppression of skin tumor promotion by TPA, the irreversible inhibitor of ODC, alpha-difluoromethylornithine (DFMO), was used. Tetradecanoylphorbol Acetate 16-19 ornithine decarboxylase, structural 1 Mus musculus 28-31 11960919-3 2002 In short-term experiments, expression of the ODCdn protein product was induced in the epidermis within 24 h after application of the tumor promoter tetradecanoyl phorbol acetate (TPA) to the skin, and ODC activity in the epidermis of K6/ODCdn mice was reduced by at least 75% compared with littermate controls. Tetradecanoylphorbol Acetate 148-177 ornithine decarboxylase, structural 1 Mus musculus 45-48 11960919-3 2002 In short-term experiments, expression of the ODCdn protein product was induced in the epidermis within 24 h after application of the tumor promoter tetradecanoyl phorbol acetate (TPA) to the skin, and ODC activity in the epidermis of K6/ODCdn mice was reduced by at least 75% compared with littermate controls. Tetradecanoylphorbol Acetate 179-182 ornithine decarboxylase, structural 1 Mus musculus 45-48 11960919-7 2002 Analysis of epidermis following multiple TPA applications revealed a dramatic spike in ODC activity in both K6/ODCdn mice and non-transgenic mice after six applications, and western blot analysis suggested a stabilization of endogenous wild-type ODC in K6/ODCdn transgenic mice. Tetradecanoylphorbol Acetate 41-44 ornithine decarboxylase, structural 1 Mus musculus 87-90 11960919-7 2002 Analysis of epidermis following multiple TPA applications revealed a dramatic spike in ODC activity in both K6/ODCdn mice and non-transgenic mice after six applications, and western blot analysis suggested a stabilization of endogenous wild-type ODC in K6/ODCdn transgenic mice. Tetradecanoylphorbol Acetate 41-44 ornithine decarboxylase, structural 1 Mus musculus 111-114 11338405-13 2001 alpha-Tocopherol pretreatment inhibited the induction of ODC enzyme activity by TPA treatment combined with UVA exposure (TPA + UVA); however, alpha-tocopherol had less of an inhibitory effect on ODC mRNA induction by TPA + UVA. Tetradecanoylphorbol Acetate 80-83 ornithine decarboxylase, structural 1 Mus musculus 57-60 11853879-5 2002 Treatment of B16 cells with TPA or alphaMSH rapidly stimulated ODC activity. Tetradecanoylphorbol Acetate 28-31 ornithine decarboxylase, structural 1 Mus musculus 63-66 12416263-5 2002 Western and Northern blots indicated that TF-3 significantly reduced the protein and mRNA levels of ODC in TPA-treated mouse skin and NIH 3T3 cells, whereas EGCG showed less activity. Tetradecanoylphorbol Acetate 107-110 ornithine decarboxylase, structural 1 Mus musculus 100-103 11551496-7 2001 Induction of TPA-induced mouse epidermal ornithine decarboxylase (ODC) activity and H(2)O(2)- and UV-induced formation of oxidized DNA bases in vitro were also attenuated by the above compounds. Tetradecanoylphorbol Acetate 13-16 ornithine decarboxylase, structural 1 Mus musculus 41-64 11551496-7 2001 Induction of TPA-induced mouse epidermal ornithine decarboxylase (ODC) activity and H(2)O(2)- and UV-induced formation of oxidized DNA bases in vitro were also attenuated by the above compounds. Tetradecanoylphorbol Acetate 13-16 ornithine decarboxylase, structural 1 Mus musculus 66-69 11338405-3 2001 Furthermore, our group demonstrated that UVA enhanced 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated induction of ornithine decarboxylase (ODC) activity in mouse skin (1). Tetradecanoylphorbol Acetate 54-90 ornithine decarboxylase, structural 1 Mus musculus 119-142 11338405-3 2001 Furthermore, our group demonstrated that UVA enhanced 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated induction of ornithine decarboxylase (ODC) activity in mouse skin (1). Tetradecanoylphorbol Acetate 54-90 ornithine decarboxylase, structural 1 Mus musculus 144-147 11338405-3 2001 Furthermore, our group demonstrated that UVA enhanced 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated induction of ornithine decarboxylase (ODC) activity in mouse skin (1). Tetradecanoylphorbol Acetate 92-95 ornithine decarboxylase, structural 1 Mus musculus 119-142 11338405-3 2001 Furthermore, our group demonstrated that UVA enhanced 12-O-tetradecanoylphorbol-13-acetate (TPA)-mediated induction of ornithine decarboxylase (ODC) activity in mouse skin (1). Tetradecanoylphorbol Acetate 92-95 ornithine decarboxylase, structural 1 Mus musculus 144-147 11338405-11 2001 UVA slightly enhanced TPA-mediated ODC mRNA induction, while it enhanced ODC enzyme activity 70%. Tetradecanoylphorbol Acetate 22-25 ornithine decarboxylase, structural 1 Mus musculus 35-38 12201673-5 2002 In parallel with suppression of tumor promotion, topically applied yakuchinone A and B markedly inhibited TPA-induced epidermal ODC activity and ODC mRNA expression. Tetradecanoylphorbol Acetate 106-109 ornithine decarboxylase, structural 1 Mus musculus 128-131 12201673-5 2002 In parallel with suppression of tumor promotion, topically applied yakuchinone A and B markedly inhibited TPA-induced epidermal ODC activity and ODC mRNA expression. Tetradecanoylphorbol Acetate 106-109 ornithine decarboxylase, structural 1 Mus musculus 145-148 11477572-11 2001 Despite long-term papilloma inhibition in both PKC delta and PKC epsilon transgenic mice, the induction of ODC by TPA was not attenuated in PKC delta and epsilon mouse lines. Tetradecanoylphorbol Acetate 114-117 ornithine decarboxylase, structural 1 Mus musculus 107-110 11477572-14 2001 TPA-induced ODC activity and the resultant accumulation of polyamines may play different roles (e.g., induction of apoptosis vs. proliferation) in the pathways leading to the induction of cancer in PKC alpha, PKC delta and PKC epsilon transgenic mice. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 12-15 11507056-3 2001 K5-AZ mice treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) at 0 and 24 h exhibit increases in epidermal and dermal ODC activity that are reduced in magnitude. Tetradecanoylphorbol Acetate 24-60 ornithine decarboxylase, structural 1 Mus musculus 123-126 11507056-3 2001 K5-AZ mice treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) at 0 and 24 h exhibit increases in epidermal and dermal ODC activity that are reduced in magnitude. Tetradecanoylphorbol Acetate 62-65 ornithine decarboxylase, structural 1 Mus musculus 123-126 11338405-13 2001 alpha-Tocopherol pretreatment inhibited the induction of ODC enzyme activity by TPA treatment combined with UVA exposure (TPA + UVA); however, alpha-tocopherol had less of an inhibitory effect on ODC mRNA induction by TPA + UVA. Tetradecanoylphorbol Acetate 122-125 ornithine decarboxylase, structural 1 Mus musculus 57-60 11338405-13 2001 alpha-Tocopherol pretreatment inhibited the induction of ODC enzyme activity by TPA treatment combined with UVA exposure (TPA + UVA); however, alpha-tocopherol had less of an inhibitory effect on ODC mRNA induction by TPA + UVA. Tetradecanoylphorbol Acetate 122-125 ornithine decarboxylase, structural 1 Mus musculus 57-60 11338405-14 2001 Curcumin, a plant pigment, dramatically inhibited both TPA- and TPA + UVA-induced expression of ODC and MT genes. Tetradecanoylphorbol Acetate 55-58 ornithine decarboxylase, structural 1 Mus musculus 96-99 11338405-14 2001 Curcumin, a plant pigment, dramatically inhibited both TPA- and TPA + UVA-induced expression of ODC and MT genes. Tetradecanoylphorbol Acetate 64-67 ornithine decarboxylase, structural 1 Mus musculus 96-99 11338405-15 2001 CONCLUSIONS: These results demonstrate that UVA can induce MT gene expression and enhance TPA-induced ODC and MT gene expression. Tetradecanoylphorbol Acetate 90-93 ornithine decarboxylase, structural 1 Mus musculus 102-105 11235918-6 2001 Increased ODC gene and SAMDC gene expression in response to phorbol-12-myristate-13-acetate (PMA) treatment was found to involve transcriptional events in both NR3 cells and in C2 cells. Tetradecanoylphorbol Acetate 60-91 ornithine decarboxylase, structural 1 Mus musculus 10-13 11235918-6 2001 Increased ODC gene and SAMDC gene expression in response to phorbol-12-myristate-13-acetate (PMA) treatment was found to involve transcriptional events in both NR3 cells and in C2 cells. Tetradecanoylphorbol Acetate 93-96 ornithine decarboxylase, structural 1 Mus musculus 10-13 11149424-0 2001 Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition. Tetradecanoylphorbol Acetate 85-121 ornithine decarboxylase, structural 1 Mus musculus 130-153 11149424-0 2001 Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition. Tetradecanoylphorbol Acetate 85-121 ornithine decarboxylase, structural 1 Mus musculus 155-158 11149424-0 2001 Retinoic acid (RA) receptor transcriptional activation correlates with inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase (ODC) activity by retinoids: a potential role for trans-RA-induced ZBP-89 in ODC inhibition. Tetradecanoylphorbol Acetate 85-121 ornithine decarboxylase, structural 1 Mus musculus 231-234 10903418-16 2000 The decrease in TPA-induced ODC activity due to GPF treatment is preceded by an inhibition of TPA-induced PKC activity. Tetradecanoylphorbol Acetate 16-19 ornithine decarboxylase, structural 1 Mus musculus 28-31 10903418-0 2000 Inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin ornithine decarboxylase and protein kinase C by polyphenolics from grapes. Tetradecanoylphorbol Acetate 14-50 ornithine decarboxylase, structural 1 Mus musculus 76-99 10674181-4 1999 NA reduced tumor growth, inhibited the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase activity, but induced the transglutaminase activity which was inhibited by TPA under different experimental conditions. Tetradecanoylphorbol Acetate 39-75 ornithine decarboxylase, structural 1 Mus musculus 90-113 10903418-0 2000 Inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin ornithine decarboxylase and protein kinase C by polyphenolics from grapes. Tetradecanoylphorbol Acetate 52-55 ornithine decarboxylase, structural 1 Mus musculus 76-99 10903418-3 2000 The present studies were designed to further characterize the effect of time and dose of application of GPF on TPA-induced ODC activity and protein expression, and on protein kinase C activity in mouse skin epidermis. Tetradecanoylphorbol Acetate 111-114 ornithine decarboxylase, structural 1 Mus musculus 123-126 10903418-8 2000 Application of grape polyphenolics (20 mg) at 60 and 30 min prior to treatment with TPA inhibited ODC activity by 62 and 68%, respectively, compared with controls (P<0.05). Tetradecanoylphorbol Acetate 84-87 ornithine decarboxylase, structural 1 Mus musculus 98-101 10523861-1 1999 Activator protein 1 (AP-1) transactivation and ornithine decarboxylase (ODC) activity have been established as essential downstream effectors of mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 175-211 ornithine decarboxylase, structural 1 Mus musculus 47-70 10523861-1 1999 Activator protein 1 (AP-1) transactivation and ornithine decarboxylase (ODC) activity have been established as essential downstream effectors of mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 175-211 ornithine decarboxylase, structural 1 Mus musculus 72-75 10874208-6 2000 Induction of skin tumors was significantly accelerated in the DMA-treated group, as well as in the TPA-treated group, indicating that DMA has a promoting effect on skin tumorigenesis in K6 / ODC transgenic mice. Tetradecanoylphorbol Acetate 99-102 ornithine decarboxylase, structural 1 Mus musculus 191-194 10615860-0 1999 Evaluation of the potential of cancer chemopreventive activity mediated by inhibition of 12-O-tetradecanoyl phorbol 13-acetate-induced ornithine decarboxylase activity. Tetradecanoylphorbol Acetate 89-126 ornithine decarboxylase, structural 1 Mus musculus 135-158 10615860-1 1999 In order to discover new cancer chemopreventive agents from natural or synthetic products, a structurally diverse class of chemopreventive agents was evaluated using in vitro biomarker of inhibition of 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in cultured mouse epidermal 308 (ME 308) cells. Tetradecanoylphorbol Acetate 202-238 ornithine decarboxylase, structural 1 Mus musculus 253-276 10674181-4 1999 NA reduced tumor growth, inhibited the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase activity, but induced the transglutaminase activity which was inhibited by TPA under different experimental conditions. Tetradecanoylphorbol Acetate 77-80 ornithine decarboxylase, structural 1 Mus musculus 90-113 9868866-1 1998 The correlation between ornithine decarboxylase (ODC) protein induction and specific protein kinase C (PKC) isozyme expression by gamma-ray in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated normal and v-rasHa transformed mouse keratinocytes was examined. Tetradecanoylphorbol Acetate 181-184 ornithine decarboxylase, structural 1 Mus musculus 24-47 10487519-4 1999 However, induction of K6-driven tTA expression by the tumor promoter (12-O-tetradecanoylphorbol-13-acetate) (TPA) led to very high levels of epidermal ODC activity and robust hyperplasia, especially involving hair follicles. Tetradecanoylphorbol Acetate 70-106 ornithine decarboxylase, structural 1 Mus musculus 151-154 10487519-4 1999 However, induction of K6-driven tTA expression by the tumor promoter (12-O-tetradecanoylphorbol-13-acetate) (TPA) led to very high levels of epidermal ODC activity and robust hyperplasia, especially involving hair follicles. Tetradecanoylphorbol Acetate 109-112 ornithine decarboxylase, structural 1 Mus musculus 151-154 10487519-6 1999 Finally, the number of papillomas that developed in a standard (7,12-dimethybenz[a]anthracene) (DMBA)/TPA protocol was greatly reduced in mice in which transgenic Odc expression was repressed by doxycycline. Tetradecanoylphorbol Acetate 102-105 ornithine decarboxylase, structural 1 Mus musculus 163-166 10487519-7 1999 Our results demonstrated that the higher levels of ODC expression produced in the transgenic model in the induced versus the repressed condition make the normally promotion-resistant C57Bl/6 strain much more sensitive to the short-term and long-term (i.e., tumor-promoting) effects of TPA. Tetradecanoylphorbol Acetate 285-288 ornithine decarboxylase, structural 1 Mus musculus 51-54 10426820-6 1999 In screening anti-tumor promoting effects, APS (180 micrograms/ml) significantly inhibited phorbol myristic acetate (PMA)-induced ornithine decarboxylase activity in Balb/3T3 cells. Tetradecanoylphorbol Acetate 117-120 ornithine decarboxylase, structural 1 Mus musculus 130-153 10403548-0 1999 Inositol hexaphosphate reduces 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase independent of protein kinase C isoform expression in keratinocytes. Tetradecanoylphorbol Acetate 31-67 ornithine decarboxylase, structural 1 Mus musculus 76-99 10403548-3 1999 In this study, we investigated the effect of InsP6 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity, an essential event in tumor promotion in HEL-30 cells, a murine keratinocyte cell line and SENCAR mouse skin. Tetradecanoylphorbol Acetate 54-90 ornithine decarboxylase, structural 1 Mus musculus 105-128 10403548-3 1999 In this study, we investigated the effect of InsP6 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity, an essential event in tumor promotion in HEL-30 cells, a murine keratinocyte cell line and SENCAR mouse skin. Tetradecanoylphorbol Acetate 54-90 ornithine decarboxylase, structural 1 Mus musculus 130-133 10403548-3 1999 In this study, we investigated the effect of InsP6 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity, an essential event in tumor promotion in HEL-30 cells, a murine keratinocyte cell line and SENCAR mouse skin. Tetradecanoylphorbol Acetate 92-95 ornithine decarboxylase, structural 1 Mus musculus 105-128 10403548-8 1999 These results indicate that InsP6 reduces TPA-induced ODC activity independent of PKC isoform expression. Tetradecanoylphorbol Acetate 42-45 ornithine decarboxylase, structural 1 Mus musculus 54-57 10363574-7 1999 Ornithine decarboxylase (ODC) activity following topical application of phytol was increased in a dose-dependent manner and showed a weak, delayed induction (which was maximal 11-12 h after treatment) as compared with the case of TPA. Tetradecanoylphorbol Acetate 230-233 ornithine decarboxylase, structural 1 Mus musculus 25-28 10096423-3 1999 Pretreatment of mouse skin with 5, 10, 20 and 30 mg of GSP resulted in a dose-dependent reduction in TPA-induced epidermal ODC activity of 27, 37, 48 and 70%, respectively, compared to controls. Tetradecanoylphorbol Acetate 101-104 ornithine decarboxylase, structural 1 Mus musculus 123-126 10096423-8 1999 The mechanism of this tumor inhibition is due, in part, to a GSP-associated inhibition of TPA-induced epidermal ODC and MPO activities. Tetradecanoylphorbol Acetate 90-93 ornithine decarboxylase, structural 1 Mus musculus 112-115 10211940-0 1999 Inhibitory effect of munetone, an isoflavonoid, on 12-O-tetradecanoylphorbol 13-acetate-induced ornithine decarboxylase activity. Tetradecanoylphorbol Acetate 51-87 ornithine decarboxylase, structural 1 Mus musculus 96-119 10211940-2 1999 (Leguminosae) that was active in the process of inhibiting 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase activity (ODC) in cultured mouse epidermal ME 308 cells, the isoflavonoid munetone was isolated and identified as an active principle (IC50 = 46 ng/ml). Tetradecanoylphorbol Acetate 59-95 ornithine decarboxylase, structural 1 Mus musculus 110-133 10211940-2 1999 (Leguminosae) that was active in the process of inhibiting 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase activity (ODC) in cultured mouse epidermal ME 308 cells, the isoflavonoid munetone was isolated and identified as an active principle (IC50 = 46 ng/ml). Tetradecanoylphorbol Acetate 59-95 ornithine decarboxylase, structural 1 Mus musculus 144-147 10211940-2 1999 (Leguminosae) that was active in the process of inhibiting 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase activity (ODC) in cultured mouse epidermal ME 308 cells, the isoflavonoid munetone was isolated and identified as an active principle (IC50 = 46 ng/ml). Tetradecanoylphorbol Acetate 97-100 ornithine decarboxylase, structural 1 Mus musculus 110-133 10211940-2 1999 (Leguminosae) that was active in the process of inhibiting 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase activity (ODC) in cultured mouse epidermal ME 308 cells, the isoflavonoid munetone was isolated and identified as an active principle (IC50 = 46 ng/ml). Tetradecanoylphorbol Acetate 97-100 ornithine decarboxylase, structural 1 Mus musculus 144-147 10211940-4 1999 In addition, munetone inhibited TPA-independent c-Myc-induced ODC activity with cultured BALB/c c-MycER cells, as well as 7,12-dimethylbenz[a]anthracene (DMBA)-induced preneoplastic lesion formation in a mouse mammary gland organ culture (MMOC) system. Tetradecanoylphorbol Acetate 32-35 ornithine decarboxylase, structural 1 Mus musculus 62-65 10578486-4 1999 Topical application of baicalein inhibited tumor promoter-caused induction of epidermal ornithine decarboxylase activity by TPA (5 nmol). Tetradecanoylphorbol Acetate 124-127 ornithine decarboxylase, structural 1 Mus musculus 88-111 9834970-1 1998 Rotenone is the classical inhibitor of NADH: ubiquinone oxidoreductase and its analogue deguelin is a potent inhibitor of 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase mRNA steady state level and enzyme activity in mouse 308 cells (Gerhauser et al. Tetradecanoylphorbol Acetate 122-158 ornithine decarboxylase, structural 1 Mus musculus 173-196 9834970-1 1998 Rotenone is the classical inhibitor of NADH: ubiquinone oxidoreductase and its analogue deguelin is a potent inhibitor of 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ornithine decarboxylase mRNA steady state level and enzyme activity in mouse 308 cells (Gerhauser et al. Tetradecanoylphorbol Acetate 160-163 ornithine decarboxylase, structural 1 Mus musculus 173-196 9868866-1 1998 The correlation between ornithine decarboxylase (ODC) protein induction and specific protein kinase C (PKC) isozyme expression by gamma-ray in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated normal and v-rasHa transformed mouse keratinocytes was examined. Tetradecanoylphorbol Acetate 181-184 ornithine decarboxylase, structural 1 Mus musculus 49-52 9868866-6 1998 Gamma-ray increases ODC protein expression in both TPA-treated normal and v-rasHa transformed mouse keratinocytes and this phenomenon correlated to the increased induction of PKC alpha without altering other PKC isozymes. Tetradecanoylphorbol Acetate 51-54 ornithine decarboxylase, structural 1 Mus musculus 20-23 9868866-8 1998 These results indicate that PKC alpha as an important regulator of mouse epidermal changes by gamma-radiation, contributes to the ODC expression occurring during exposure to tumor promoter, such as TPA, and epidermal neoplasia induced by ras activation. Tetradecanoylphorbol Acetate 198-201 ornithine decarboxylase, structural 1 Mus musculus 130-133 9744550-12 1998 In contrast, genistein only exhibited a moderate inhibition of TPA-induced ornithine decarboxylase activity (P > 0.05). Tetradecanoylphorbol Acetate 63-66 ornithine decarboxylase, structural 1 Mus musculus 75-98 9585067-5 1998 When it was applied to the dorsal surface of CD-1 mice before TPA application, PCA (5, 10 or 20 micromol) inhibited the induction of epidermal ornithine decarboxylase (ODC) activity by 5 nmol TPA and myeloperoxidase (MPO) activity by 6.5 nmol TPA. Tetradecanoylphorbol Acetate 192-195 ornithine decarboxylase, structural 1 Mus musculus 143-166 9719465-6 1998 (3) Pheophytin a and b from green tea showed inhibitory effects against early induction of ornithine decarboxylase (ODC) in BALB/c mouse skin fibroblasts caused by TPA. Tetradecanoylphorbol Acetate 164-167 ornithine decarboxylase, structural 1 Mus musculus 91-114 9719465-6 1998 (3) Pheophytin a and b from green tea showed inhibitory effects against early induction of ornithine decarboxylase (ODC) in BALB/c mouse skin fibroblasts caused by TPA. Tetradecanoylphorbol Acetate 164-167 ornithine decarboxylase, structural 1 Mus musculus 116-119 9711216-5 1998 In vivo, the application of K1115 A decreased phorbol myristate acetate (PMA)-induced mouse ornithine decarboxylase (ODC) activity. Tetradecanoylphorbol Acetate 46-71 ornithine decarboxylase, structural 1 Mus musculus 92-115 9711216-5 1998 In vivo, the application of K1115 A decreased phorbol myristate acetate (PMA)-induced mouse ornithine decarboxylase (ODC) activity. Tetradecanoylphorbol Acetate 46-71 ornithine decarboxylase, structural 1 Mus musculus 117-120 9711216-5 1998 In vivo, the application of K1115 A decreased phorbol myristate acetate (PMA)-induced mouse ornithine decarboxylase (ODC) activity. Tetradecanoylphorbol Acetate 73-76 ornithine decarboxylase, structural 1 Mus musculus 92-115 9711216-5 1998 In vivo, the application of K1115 A decreased phorbol myristate acetate (PMA)-induced mouse ornithine decarboxylase (ODC) activity. Tetradecanoylphorbol Acetate 73-76 ornithine decarboxylase, structural 1 Mus musculus 117-120 9585067-5 1998 When it was applied to the dorsal surface of CD-1 mice before TPA application, PCA (5, 10 or 20 micromol) inhibited the induction of epidermal ornithine decarboxylase (ODC) activity by 5 nmol TPA and myeloperoxidase (MPO) activity by 6.5 nmol TPA. Tetradecanoylphorbol Acetate 192-195 ornithine decarboxylase, structural 1 Mus musculus 168-171 9585067-5 1998 When it was applied to the dorsal surface of CD-1 mice before TPA application, PCA (5, 10 or 20 micromol) inhibited the induction of epidermal ornithine decarboxylase (ODC) activity by 5 nmol TPA and myeloperoxidase (MPO) activity by 6.5 nmol TPA. Tetradecanoylphorbol Acetate 192-195 ornithine decarboxylase, structural 1 Mus musculus 143-166 9585067-5 1998 When it was applied to the dorsal surface of CD-1 mice before TPA application, PCA (5, 10 or 20 micromol) inhibited the induction of epidermal ornithine decarboxylase (ODC) activity by 5 nmol TPA and myeloperoxidase (MPO) activity by 6.5 nmol TPA. Tetradecanoylphorbol Acetate 192-195 ornithine decarboxylase, structural 1 Mus musculus 168-171 9270008-1 1997 Deguelin, a natural product isolated from Mundulea sericea (Leguminosae), was shown previously to mediate strong inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in cell culture and to reduce the formation of preneoplastic lesions when mouse mammary glands were exposed to 7,12-dimethylbenz(a)anthracene. Tetradecanoylphorbol Acetate 127-163 ornithine decarboxylase, structural 1 Mus musculus 203-206 9270009-8 1997 Moreover, inhibition of this enzyme correlated with a rapid depletion of ATP levels and potential to inhibit either TPA- or c-Myc-induced ODC activity. Tetradecanoylphorbol Acetate 116-119 ornithine decarboxylase, structural 1 Mus musculus 138-141 9363999-7 1997 Pre-application of BTP to that of TPA also resulted in significant inhibition of TPA-caused induction of epidermal ODC (23-73%, P < 0.005-0.0001), and cyclo-oxygenase, in terms of prostaglandins metabolites formation (38-65%, P < 0.01-0.0005), enzyme activities. Tetradecanoylphorbol Acetate 34-37 ornithine decarboxylase, structural 1 Mus musculus 115-118 9363999-7 1997 Pre-application of BTP to that of TPA also resulted in significant inhibition of TPA-caused induction of epidermal ODC (23-73%, P < 0.005-0.0001), and cyclo-oxygenase, in terms of prostaglandins metabolites formation (38-65%, P < 0.01-0.0005), enzyme activities. Tetradecanoylphorbol Acetate 81-84 ornithine decarboxylase, structural 1 Mus musculus 115-118 9270008-1 1997 Deguelin, a natural product isolated from Mundulea sericea (Leguminosae), was shown previously to mediate strong inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in cell culture and to reduce the formation of preneoplastic lesions when mouse mammary glands were exposed to 7,12-dimethylbenz(a)anthracene. Tetradecanoylphorbol Acetate 165-168 ornithine decarboxylase, structural 1 Mus musculus 203-206 9270008-5 1997 These results correlated with the potential of deguelin to inhibit TPA-induced mouse epidermal ODC activity. Tetradecanoylphorbol Acetate 67-70 ornithine decarboxylase, structural 1 Mus musculus 95-98 9270008-6 1997 When applied topically as a single dose in a time range of 2 h before to 2 h after TPA treatment, deguelin (384 microg) reduced ODC induction by TPA (6.17 microg) by more than 85%. Tetradecanoylphorbol Acetate 145-148 ornithine decarboxylase, structural 1 Mus musculus 128-131 9270008-7 1997 Time course studies indicated that deguelin (33 microg) inhibited TPA (1.17 microg)-induced ODC activity by 70% without affecting the kinetics of induction over a period of 10 h. Complete inhibition of ODC induction was observed at a dose of 330 microg of deguelin. Tetradecanoylphorbol Acetate 66-69 ornithine decarboxylase, structural 1 Mus musculus 92-95 9270008-7 1997 Time course studies indicated that deguelin (33 microg) inhibited TPA (1.17 microg)-induced ODC activity by 70% without affecting the kinetics of induction over a period of 10 h. Complete inhibition of ODC induction was observed at a dose of 330 microg of deguelin. Tetradecanoylphorbol Acetate 66-69 ornithine decarboxylase, structural 1 Mus musculus 202-205 9270009-3 1997 Using cultured mouse epidermal 308 cells, the steady-state levels of both 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ODC mRNA and c-fos were decreased by treatment with deguelin. Tetradecanoylphorbol Acetate 74-110 ornithine decarboxylase, structural 1 Mus musculus 125-128 9270009-3 1997 Using cultured mouse epidermal 308 cells, the steady-state levels of both 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ODC mRNA and c-fos were decreased by treatment with deguelin. Tetradecanoylphorbol Acetate 112-115 ornithine decarboxylase, structural 1 Mus musculus 125-128 9270009-4 1997 ODC activity was also inhibited by bullatacin and various antimitotic agents (podophyllotoxin, vinblastine, and colchicine), but only deguelin and bullatacin were active as inhibitors of ODC levels in a TPA-independent c-Myc-mediated induction system using cultured BALB/c c-MycER cells. Tetradecanoylphorbol Acetate 203-206 ornithine decarboxylase, structural 1 Mus musculus 0-3 9591190-4 1997 It also reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in skin inflammation, epidermal DNA synthesis, ornithine decarboxylase (ODC) mRNA level, ODC activity, hyperplasia, formation of c-Fos, and c-Jun proteins, hydrogen peroxide, and the oxidized DNA base 5-hydroxymethyl-2"-deoxyuridine (HmdU). Tetradecanoylphorbol Acetate 16-52 ornithine decarboxylase, structural 1 Mus musculus 124-147 9370104-3 1997 Sandalwood oil treatment significantly decreased papilloma incidence by 67%, multiplicity by 96%, and TPA-induced ODC activity by 70%. Tetradecanoylphorbol Acetate 102-105 ornithine decarboxylase, structural 1 Mus musculus 114-117 21533386-4 1997 Raspberry extract (2x15 mg) containing sanguiin H6 and lambertianin D as well as oligomeric procyanidins (2x15 mg) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity by about 30%. Tetradecanoylphorbol Acetate 123-159 ornithine decarboxylase, structural 1 Mus musculus 174-197 21533386-4 1997 Raspberry extract (2x15 mg) containing sanguiin H6 and lambertianin D as well as oligomeric procyanidins (2x15 mg) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity by about 30%. Tetradecanoylphorbol Acetate 123-159 ornithine decarboxylase, structural 1 Mus musculus 199-202 21533386-7 1997 Our results su est that hydrolyzable and condensed tannins from various sources, which can inhibit the ODC, HPx, and DNA responses to TPA, might also inhibit the tumor-promoting activity of this agent. Tetradecanoylphorbol Acetate 134-137 ornithine decarboxylase, structural 1 Mus musculus 103-106 9591190-4 1997 It also reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in skin inflammation, epidermal DNA synthesis, ornithine decarboxylase (ODC) mRNA level, ODC activity, hyperplasia, formation of c-Fos, and c-Jun proteins, hydrogen peroxide, and the oxidized DNA base 5-hydroxymethyl-2"-deoxyuridine (HmdU). Tetradecanoylphorbol Acetate 16-52 ornithine decarboxylase, structural 1 Mus musculus 149-152 9591190-4 1997 It also reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in skin inflammation, epidermal DNA synthesis, ornithine decarboxylase (ODC) mRNA level, ODC activity, hyperplasia, formation of c-Fos, and c-Jun proteins, hydrogen peroxide, and the oxidized DNA base 5-hydroxymethyl-2"-deoxyuridine (HmdU). Tetradecanoylphorbol Acetate 16-52 ornithine decarboxylase, structural 1 Mus musculus 166-169 9591190-4 1997 It also reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in skin inflammation, epidermal DNA synthesis, ornithine decarboxylase (ODC) mRNA level, ODC activity, hyperplasia, formation of c-Fos, and c-Jun proteins, hydrogen peroxide, and the oxidized DNA base 5-hydroxymethyl-2"-deoxyuridine (HmdU). Tetradecanoylphorbol Acetate 54-57 ornithine decarboxylase, structural 1 Mus musculus 124-147 9591190-4 1997 It also reduces 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced increases in skin inflammation, epidermal DNA synthesis, ornithine decarboxylase (ODC) mRNA level, ODC activity, hyperplasia, formation of c-Fos, and c-Jun proteins, hydrogen peroxide, and the oxidized DNA base 5-hydroxymethyl-2"-deoxyuridine (HmdU). Tetradecanoylphorbol Acetate 54-57 ornithine decarboxylase, structural 1 Mus musculus 149-152 9022291-2 1996 The aim of the present study was to evaluate the influence of 12-O-tetradecanoylphorbol 13-acetate (TPA)--a potent ODC inducer on antiproliferative and apoptotic effects of TGF-beta 1 in L1210 leukemic cells. Tetradecanoylphorbol Acetate 100-103 ornithine decarboxylase, structural 1 Mus musculus 115-118 8899846-3 1996 The influence of apigenin in DMSO, A/D (4:1), and propylene glycol/DMSO (PG/D, 4:1) on 12-O-tetradecanoylphorbol-13 acetate (TPA) induced ornithine decarboxylase (ODC) activity was compared. Tetradecanoylphorbol Acetate 87-123 ornithine decarboxylase, structural 1 Mus musculus 138-161 9022291-0 1996 Phorbol ester (12-O-tetradecanoylphorbol 13-acetate) prevents ornithine decarboxylase inhibition and apoptosis and L1210 leukemic cells exposed to TGF-beta 1. Tetradecanoylphorbol Acetate 15-51 ornithine decarboxylase, structural 1 Mus musculus 62-85 9022291-2 1996 The aim of the present study was to evaluate the influence of 12-O-tetradecanoylphorbol 13-acetate (TPA)--a potent ODC inducer on antiproliferative and apoptotic effects of TGF-beta 1 in L1210 leukemic cells. Tetradecanoylphorbol Acetate 62-98 ornithine decarboxylase, structural 1 Mus musculus 115-118 9022291-10 1996 Administration of TPA simultaneously with TGF-beta 1 significantly reduced antiproliferative, apoptotic and necrotic effects of TGF-beta 1, and prevented its inhibitory action of ODC expression and activity. Tetradecanoylphorbol Acetate 18-21 ornithine decarboxylase, structural 1 Mus musculus 179-182 9022291-11 1996 It is concluded that: down-regulation of ODC expression may be one of the early events associated with TGF-beta 1-evoked suppression of growth and apoptosis; ODC is involved in the mechanism of protective action of TPA on TGF-beta 1-related growth inhibition of L1210 leukemic cells. Tetradecanoylphorbol Acetate 215-218 ornithine decarboxylase, structural 1 Mus musculus 41-44 9022291-11 1996 It is concluded that: down-regulation of ODC expression may be one of the early events associated with TGF-beta 1-evoked suppression of growth and apoptosis; ODC is involved in the mechanism of protective action of TPA on TGF-beta 1-related growth inhibition of L1210 leukemic cells. Tetradecanoylphorbol Acetate 215-218 ornithine decarboxylase, structural 1 Mus musculus 158-161 8931867-2 1996 Tacalcitol was shown to inhibit epidermal proliferation using TPA-induced ornithine decarboxylase activity and DNA synthesis as indices, and the induction of epidermal differentiation using type I transglutaminase activity as an index. Tetradecanoylphorbol Acetate 62-65 ornithine decarboxylase, structural 1 Mus musculus 74-97 8899846-8 1996 Inhibition of TPA-induced ODC by apigenin in three vehicles was in the order of DMSO > A/D > PG/D. Tetradecanoylphorbol Acetate 14-17 ornithine decarboxylase, structural 1 Mus musculus 26-29 8899846-9 1996 TPA-induced ODC in dorsal skin was not inhibited by apigenin delivered from abdominal skin. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 12-15 8899846-12 1996 CONCLUSIONS: (a) The short-term TPA-induced ODC was validated for evaluating topical formulations of apigenin. Tetradecanoylphorbol Acetate 32-35 ornithine decarboxylase, structural 1 Mus musculus 44-47 8700159-1 1996 A correlation of the levels of epidermal protein kinase C (PKC) isozymes, steady state levels of ornithine decarboxylase (ODC) mRNA, and ODC antizyme with the induction of ornithine decarboxylase (ODC) activity by a second repeat 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment to mouse skin was determined. Tetradecanoylphorbol Acetate 268-271 ornithine decarboxylase, structural 1 Mus musculus 172-195 8635865-7 1996 CPT may indirectly decrease the ornithine decarboxylase-inducing activity of multiple TPA treatments because it can inhibit the stimulation of RNA synthesis by this compound. Tetradecanoylphorbol Acetate 86-89 ornithine decarboxylase, structural 1 Mus musculus 32-55 8640756-6 1996 Preapplication of GE onto the skin of SENCAR mice resulted in significant inhibition of 12-0-tetradecanoylphorbol-13-acetate (TPA)-caused induction of epidermal ODC, cyclooxygenase, and lipoxygenase activities and ODC mRNA expression in a does-dependent manner. Tetradecanoylphorbol Acetate 126-129 ornithine decarboxylase, structural 1 Mus musculus 214-217 8700159-3 1996 However, a superinduction of ODC activity (approximately 13 CO2/60 min/mg protein) is observed upon the second TPA application at 48 or 72 h after the first TPA treatment. Tetradecanoylphorbol Acetate 157-160 ornithine decarboxylase, structural 1 Mus musculus 29-32 8830802-4 1996 Furthermore chlorophyllin also exhibited a dose-dependent inhibition on 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity of 3T3 fibroblast cells at the same concentrations. Tetradecanoylphorbol Acetate 72-109 ornithine decarboxylase, structural 1 Mus musculus 124-147 8830802-4 1996 Furthermore chlorophyllin also exhibited a dose-dependent inhibition on 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity of 3T3 fibroblast cells at the same concentrations. Tetradecanoylphorbol Acetate 72-109 ornithine decarboxylase, structural 1 Mus musculus 149-152 8830802-4 1996 Furthermore chlorophyllin also exhibited a dose-dependent inhibition on 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity of 3T3 fibroblast cells at the same concentrations. Tetradecanoylphorbol Acetate 111-114 ornithine decarboxylase, structural 1 Mus musculus 124-147 8830802-4 1996 Furthermore chlorophyllin also exhibited a dose-dependent inhibition on 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity of 3T3 fibroblast cells at the same concentrations. Tetradecanoylphorbol Acetate 111-114 ornithine decarboxylase, structural 1 Mus musculus 149-152 8700159-0 1996 Superinduction of mouse epidermal ornithine decarboxylase activity by repeated 12-o-tetradecanoylphorbol-13-acetate treatments. Tetradecanoylphorbol Acetate 79-115 ornithine decarboxylase, structural 1 Mus musculus 34-57 8700159-2 1996 A single application of TPA to female CD-1 mouse skin leads to a dramatic induction of ODC activity (approximately 3 nmol CO2/60 min/mg protein) which peaks at about 5 h after treatment. Tetradecanoylphorbol Acetate 24-27 ornithine decarboxylase, structural 1 Mus musculus 87-90 8700159-1 1996 A correlation of the levels of epidermal protein kinase C (PKC) isozymes, steady state levels of ornithine decarboxylase (ODC) mRNA, and ODC antizyme with the induction of ornithine decarboxylase (ODC) activity by a second repeat 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment to mouse skin was determined. Tetradecanoylphorbol Acetate 230-266 ornithine decarboxylase, structural 1 Mus musculus 172-195 8700159-3 1996 However, a superinduction of ODC activity (approximately 13 CO2/60 min/mg protein) is observed upon the second TPA application at 48 or 72 h after the first TPA treatment. Tetradecanoylphorbol Acetate 111-114 ornithine decarboxylase, structural 1 Mus musculus 29-32 8700159-7 1996 TPA-induced steady state levels of ODC mRNA did not correlate with the degree of superinduction of ODC activity by TPA. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 35-38 8700159-8 1996 The second TPA treatment, 72 h after the first TPA treatment, which leads to superinduction of ODC activity did not decrease the levels of the ODC-antizyme. Tetradecanoylphorbol Acetate 11-14 ornithine decarboxylase, structural 1 Mus musculus 95-98 8993955-2 1996 OBJECT: The aim of the present study was to examine the enhancing effects of UVA on changes in mouse skin mediated by the tumor promoter 12-o-tetradecanoylphorbol-13-acetate (TPA) by measurement of ornithine decarboxylase (ODC) activity and morphometric analysis. Tetradecanoylphorbol Acetate 175-178 ornithine decarboxylase, structural 1 Mus musculus 198-221 8564924-6 1996 (2) All-trans beta-carotene caused a remarkable stimulation for the early induction of ornithine decarboxylase (ODC) activity after the stimulation of TPA and fetal bovine serum. Tetradecanoylphorbol Acetate 151-154 ornithine decarboxylase, structural 1 Mus musculus 112-115 8993955-2 1996 OBJECT: The aim of the present study was to examine the enhancing effects of UVA on changes in mouse skin mediated by the tumor promoter 12-o-tetradecanoylphorbol-13-acetate (TPA) by measurement of ornithine decarboxylase (ODC) activity and morphometric analysis. Tetradecanoylphorbol Acetate 175-178 ornithine decarboxylase, structural 1 Mus musculus 223-226 8993955-2 1996 OBJECT: The aim of the present study was to examine the enhancing effects of UVA on changes in mouse skin mediated by the tumor promoter 12-o-tetradecanoylphorbol-13-acetate (TPA) by measurement of ornithine decarboxylase (ODC) activity and morphometric analysis. Tetradecanoylphorbol Acetate 137-173 ornithine decarboxylase, structural 1 Mus musculus 223-226 8993955-6 1996 RESULTS: A combination of topical TPA application and UVA irradiation produced a greater increment of ODC activity at 4 h than TPA alone (p < 0.05). Tetradecanoylphorbol Acetate 34-37 ornithine decarboxylase, structural 1 Mus musculus 102-105 8993955-8 1996 Pretreatment of mice with curcumin significantly abrogated the TPA-induced changes in ODC activity and the dermal infiltrating inflammatory cells as well as the TPA plus UVA-mediated enhancement of these changes. Tetradecanoylphorbol Acetate 63-66 ornithine decarboxylase, structural 1 Mus musculus 86-89 8993955-9 1996 CONCLUSION: Our data indicate that UVA irradiation (18.72 J/cm2) significantly enhances ODC induction at an early stage (4-6 h) after topical application of TPA, and aggravates the dermatitis elicited by TPA. Tetradecanoylphorbol Acetate 157-160 ornithine decarboxylase, structural 1 Mus musculus 88-91 8993955-9 1996 CONCLUSION: Our data indicate that UVA irradiation (18.72 J/cm2) significantly enhances ODC induction at an early stage (4-6 h) after topical application of TPA, and aggravates the dermatitis elicited by TPA. Tetradecanoylphorbol Acetate 204-207 ornithine decarboxylase, structural 1 Mus musculus 88-91 8402584-2 1993 Topical applications of the semisynthetic flavonoids, catechin dialkyl ketals and epicatechin-4-alkylsulphides inhibit TPA-induced ornithine decarboxylase (ODC) activity to a much greater degree than catechin or epicatechin. Tetradecanoylphorbol Acetate 119-122 ornithine decarboxylase, structural 1 Mus musculus 131-154 7763014-4 1995 Topical application of geniposide inhibited tumor promoter-caused induction of epidermal ODC activity by TPA (5 nmol). Tetradecanoylphorbol Acetate 105-108 ornithine decarboxylase, structural 1 Mus musculus 89-92 7859347-4 1995 Topical application of crocetin inhibited tumor promoter-caused induction of epidermal ODC activity by TPA (5 nmol). Tetradecanoylphorbol Acetate 103-106 ornithine decarboxylase, structural 1 Mus musculus 87-90 8538195-15 1995 Curcumin enhances glutathione content and glutathione-S-transferase activity in liver; and it inhibits lipid peroxidation and arachidonic acid metabolism in mouse skin, protein kinase C activity in TPA-treated NIH 3T3 cells, chemically induced ODC and tyrosine protein kinase activities in rat colon, and 8-hydroxyguanosine formation in mouse fibroblasts. Tetradecanoylphorbol Acetate 198-201 ornithine decarboxylase, structural 1 Mus musculus 244-247 8584456-4 1995 In the second experiment, a single application of 10 nmol of TPA to mouse skin led to a marked increase in the transcripts" level of ornithine decarboxylase (ODC) gene, protein kinase C (PKC) gene, and c-myc oncogene at four hours after TPA administration. Tetradecanoylphorbol Acetate 61-64 ornithine decarboxylase, structural 1 Mus musculus 133-156 8584456-4 1995 In the second experiment, a single application of 10 nmol of TPA to mouse skin led to a marked increase in the transcripts" level of ornithine decarboxylase (ODC) gene, protein kinase C (PKC) gene, and c-myc oncogene at four hours after TPA administration. Tetradecanoylphorbol Acetate 61-64 ornithine decarboxylase, structural 1 Mus musculus 158-161 7871547-5 1994 However, TPA resulted in 100% tumor incidence and 8.8 tumors per mouse after 20 weeks of promotion, and induced epidermal ODC activity. Tetradecanoylphorbol Acetate 9-12 ornithine decarboxylase, structural 1 Mus musculus 122-125 7525612-9 1994 In addition, treatment of H-ras transformed cells with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) led to an elevation in ODC mRNA levels not observed in parental 10T1/2 fibroblasts. Tetradecanoylphorbol Acetate 75-111 ornithine decarboxylase, structural 1 Mus musculus 141-144 7525612-9 1994 In addition, treatment of H-ras transformed cells with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) led to an elevation in ODC mRNA levels not observed in parental 10T1/2 fibroblasts. Tetradecanoylphorbol Acetate 113-116 ornithine decarboxylase, structural 1 Mus musculus 141-144 21559644-1 1994 The ornithine decarboxylase (ODC), hydroperoxide (HPx) and DNA responses to 12-O-tetradecanoylphorbol-13-acetate (TPA) and mezerein (MEZ) are similar in vivo. Tetradecanoylphorbol Acetate 76-112 ornithine decarboxylase, structural 1 Mus musculus 4-27 21559644-1 1994 The ornithine decarboxylase (ODC), hydroperoxide (HPx) and DNA responses to 12-O-tetradecanoylphorbol-13-acetate (TPA) and mezerein (MEZ) are similar in vivo. Tetradecanoylphorbol Acetate 114-117 ornithine decarboxylase, structural 1 Mus musculus 4-27 21559587-4 1994 The most effective antioxidant, loblolly pine bark CT, also inhibits TPA-induced ODC activity and macromolecule synthesis to a much greater degree than catechin or the other CTs tested. Tetradecanoylphorbol Acetate 69-72 ornithine decarboxylase, structural 1 Mus musculus 81-84 8020140-0 1994 Inhibitory effect of silymarin, an anti-hepatotoxic flavonoid, on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and mRNA in SENCAR mice. Tetradecanoylphorbol Acetate 66-102 ornithine decarboxylase, structural 1 Mus musculus 121-144 8020140-4 1994 Application of silymarin at doses of 0.5-18 mg (1-37 mumol)/mouse prior to that of TPA (2.5 micrograms) treatment resulted in significant inhibition of TPA-induced epidermal ODC activity in a dose- and time-dependent manner. Tetradecanoylphorbol Acetate 152-155 ornithine decarboxylase, structural 1 Mus musculus 174-177 8020140-5 1994 Northern blot analysis revealed that topical application of silymarin at the dose of 2 mg/mouse resulted in almost complete inhibition of TPA-induced epidermal ODC mRNA. Tetradecanoylphorbol Acetate 138-141 ornithine decarboxylase, structural 1 Mus musculus 160-163 8073090-2 1994 Topical applications of the procyanidins, 15 min before the tumor promoter, inhibit TPA-induced ornithine decarboxylase (ODC) activity and this inhibition increases with the degree of polymerization (trimer > dimer > monomer). Tetradecanoylphorbol Acetate 84-87 ornithine decarboxylase, structural 1 Mus musculus 96-119 8073090-2 1994 Topical applications of the procyanidins, 15 min before the tumor promoter, inhibit TPA-induced ornithine decarboxylase (ODC) activity and this inhibition increases with the degree of polymerization (trimer > dimer > monomer). Tetradecanoylphorbol Acetate 84-87 ornithine decarboxylase, structural 1 Mus musculus 121-124 8073090-3 1994 At a dose of 10 mumol, all procyanidin dimers inhibit the ODC response to TPA to a greater degree than 20 mumol of epicatechin and 10 mumol of epicatechin and/or catechin. Tetradecanoylphorbol Acetate 74-77 ornithine decarboxylase, structural 1 Mus musculus 58-61 8073090-5 1994 At a dose of 10 mumol, the epicatechin trimer also inhibits TPA-induced ODC activity and HPx production to a greater degree than 10-30 mumol of epicatechin. Tetradecanoylphorbol Acetate 60-63 ornithine decarboxylase, structural 1 Mus musculus 72-75 8135799-1 1994 Calcium has been suggested to be an intracellular second messenger for ornithine decarboxylase (ODC) induction caused by 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 121-157 ornithine decarboxylase, structural 1 Mus musculus 71-94 8135799-1 1994 Calcium has been suggested to be an intracellular second messenger for ornithine decarboxylase (ODC) induction caused by 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 121-157 ornithine decarboxylase, structural 1 Mus musculus 96-99 8135799-1 1994 Calcium has been suggested to be an intracellular second messenger for ornithine decarboxylase (ODC) induction caused by 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 159-162 ornithine decarboxylase, structural 1 Mus musculus 71-94 8135799-1 1994 Calcium has been suggested to be an intracellular second messenger for ornithine decarboxylase (ODC) induction caused by 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 159-162 ornithine decarboxylase, structural 1 Mus musculus 96-99 8135799-2 1994 In the present study, the effects of dietary calcium supplement and calcium and verapamil injections on TPA-induced ODC activity in skin was investigated in CD-1 and SENCAR mouse. Tetradecanoylphorbol Acetate 104-107 ornithine decarboxylase, structural 1 Mus musculus 116-119 8135799-4 1994 However, calcium injections enhanced the TPA-induced ODC activity in CD-1 and SENCAR mouse skin. Tetradecanoylphorbol Acetate 41-44 ornithine decarboxylase, structural 1 Mus musculus 53-56 8135799-5 1994 Verapamil injections resulted in a significant decrease in TPA-induced ODC activity in CD-1 and SENCAR mice. Tetradecanoylphorbol Acetate 59-62 ornithine decarboxylase, structural 1 Mus musculus 71-74 8253522-8 1993 However, the Ca(2+)-ATPase inhibitor cyclopiazonic acid and the Ca2+ ionophore and weak ODC inducer A23187 mimic remarkably the HPx responses to TG and TPA. Tetradecanoylphorbol Acetate 152-155 ornithine decarboxylase, structural 1 Mus musculus 88-91 7829270-4 1995 Both DNFB and TPA caused marked induction of ODC, c-fos and c-jun mRNA. Tetradecanoylphorbol Acetate 14-17 ornithine decarboxylase, structural 1 Mus musculus 45-48 7963658-1 1994 The induction of ornithine decarboxylase levels by the phorbol ester 12-0-tetradecanoyl-phorbol-13-acetate (TPA) in mouse skin has been shown to be integral to tumor promotion by TPA, and changes in ornithine decarboxylase activity indicate the proliferative state of many different cell types. Tetradecanoylphorbol Acetate 108-111 ornithine decarboxylase, structural 1 Mus musculus 17-40 7963658-1 1994 The induction of ornithine decarboxylase levels by the phorbol ester 12-0-tetradecanoyl-phorbol-13-acetate (TPA) in mouse skin has been shown to be integral to tumor promotion by TPA, and changes in ornithine decarboxylase activity indicate the proliferative state of many different cell types. Tetradecanoylphorbol Acetate 108-111 ornithine decarboxylase, structural 1 Mus musculus 199-222 7963658-1 1994 The induction of ornithine decarboxylase levels by the phorbol ester 12-0-tetradecanoyl-phorbol-13-acetate (TPA) in mouse skin has been shown to be integral to tumor promotion by TPA, and changes in ornithine decarboxylase activity indicate the proliferative state of many different cell types. Tetradecanoylphorbol Acetate 179-182 ornithine decarboxylase, structural 1 Mus musculus 17-40 21559644-2 1994 Thapsigargin (TG) respectively mimics about 15, 75 and 75% of the ODC, HPx and DNA responses to TPA and these differences persist after chronic treatments. Tetradecanoylphorbol Acetate 96-99 ornithine decarboxylase, structural 1 Mus musculus 66-69 21559644-6 1994 But the ODC response to TG is greater when this compound is applied 48 h after TPA than after another TG treatment. Tetradecanoylphorbol Acetate 79-82 ornithine decarboxylase, structural 1 Mus musculus 8-11 7509717-11 1994 Staining for induced ODC in mice treated with 12-O-tetradecanoylphorbol-13-acetate once weekly for 7 weeks was intense and diffuse throughout the suprabasal layers of the epidermis. Tetradecanoylphorbol Acetate 46-82 ornithine decarboxylase, structural 1 Mus musculus 21-24 8402584-2 1993 Topical applications of the semisynthetic flavonoids, catechin dialkyl ketals and epicatechin-4-alkylsulphides inhibit TPA-induced ornithine decarboxylase (ODC) activity to a much greater degree than catechin or epicatechin. Tetradecanoylphorbol Acetate 119-122 ornithine decarboxylase, structural 1 Mus musculus 156-159 8401327-3 1993 Putrescine also inhibited the TPA-induced ornithine decarboxylase (ODC) activity and lowered the free sulfhydryl content of TPA exposed mouse skin. Tetradecanoylphorbol Acetate 30-33 ornithine decarboxylase, structural 1 Mus musculus 42-65 8401327-3 1993 Putrescine also inhibited the TPA-induced ornithine decarboxylase (ODC) activity and lowered the free sulfhydryl content of TPA exposed mouse skin. Tetradecanoylphorbol Acetate 30-33 ornithine decarboxylase, structural 1 Mus musculus 67-70 8403464-1 1993 The activity and gene expression of ornithine decarboxylase (ODC, an indicator of tumour promotion) were induced by the phorbol ester tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), in mouse skin. Tetradecanoylphorbol Acetate 151-187 ornithine decarboxylase, structural 1 Mus musculus 36-59 8403464-1 1993 The activity and gene expression of ornithine decarboxylase (ODC, an indicator of tumour promotion) were induced by the phorbol ester tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), in mouse skin. Tetradecanoylphorbol Acetate 151-187 ornithine decarboxylase, structural 1 Mus musculus 61-64 8403464-1 1993 The activity and gene expression of ornithine decarboxylase (ODC, an indicator of tumour promotion) were induced by the phorbol ester tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), in mouse skin. Tetradecanoylphorbol Acetate 189-192 ornithine decarboxylase, structural 1 Mus musculus 36-59 8403464-1 1993 The activity and gene expression of ornithine decarboxylase (ODC, an indicator of tumour promotion) were induced by the phorbol ester tumour promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), in mouse skin. Tetradecanoylphorbol Acetate 189-192 ornithine decarboxylase, structural 1 Mus musculus 61-64 8403464-3 1993 On administration of colchicine (100 micrograms) intraperitoneally 1.5 h before TPA treatment, ODC activity and ODC mRNA levels stimulated by TPA were suppressed to about 52 and 64%, respectively. Tetradecanoylphorbol Acetate 142-145 ornithine decarboxylase, structural 1 Mus musculus 95-98 8403464-3 1993 On administration of colchicine (100 micrograms) intraperitoneally 1.5 h before TPA treatment, ODC activity and ODC mRNA levels stimulated by TPA were suppressed to about 52 and 64%, respectively. Tetradecanoylphorbol Acetate 142-145 ornithine decarboxylase, structural 1 Mus musculus 112-115 8242794-8 1993 Expression of ornithine decarboxylase mRNA and protein is increased by vinblastine sulfate but decreased by cytochalasin B in TPA treated cells. Tetradecanoylphorbol Acetate 126-129 ornithine decarboxylase, structural 1 Mus musculus 14-37 8435870-5 1993 Intraperitoneal injection of 10 or 30 mumol curcumin 1h before topical application of 5 nmol TPA inhibited TPA-induced increases in epidermal ODC enzyme activity by 75 or 89% respectively. Tetradecanoylphorbol Acetate 93-96 ornithine decarboxylase, structural 1 Mus musculus 142-145 8453712-10 1993 Treatment of TPA-promoted mice with IFN-gamma, and to a lesser extent IFN-beta, weakly potentiated the TPA-dependent induction of epidermal ODC activity. Tetradecanoylphorbol Acetate 13-16 ornithine decarboxylase, structural 1 Mus musculus 140-143 8453712-10 1993 Treatment of TPA-promoted mice with IFN-gamma, and to a lesser extent IFN-beta, weakly potentiated the TPA-dependent induction of epidermal ODC activity. Tetradecanoylphorbol Acetate 103-106 ornithine decarboxylase, structural 1 Mus musculus 140-143 8316048-7 1993 AA-Supplemented (1.6 microM) cultures supported approximately twice the induction of ornithine decarboxylase activity by TPA compared with cultures treated with 1.8 microM LA. Tetradecanoylphorbol Acetate 121-124 ornithine decarboxylase, structural 1 Mus musculus 85-108 8435870-0 1993 Inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced increase in ornithine decarboxylase mRNA in mouse epidermis. Tetradecanoylphorbol Acetate 33-69 ornithine decarboxylase, structural 1 Mus musculus 90-113 8435870-1 1993 Application of 5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to the skin of female CD-1 mice led to a rapid increase in the concentration of epidermal ornithine decarboxylase (ODC) mRNA from an undetectable level in control mice to a high maximum level at 4-5 h after TPA administration. Tetradecanoylphorbol Acetate 22-58 ornithine decarboxylase, structural 1 Mus musculus 155-178 8435870-1 1993 Application of 5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to the skin of female CD-1 mice led to a rapid increase in the concentration of epidermal ornithine decarboxylase (ODC) mRNA from an undetectable level in control mice to a high maximum level at 4-5 h after TPA administration. Tetradecanoylphorbol Acetate 22-58 ornithine decarboxylase, structural 1 Mus musculus 180-183 8435870-1 1993 Application of 5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to the skin of female CD-1 mice led to a rapid increase in the concentration of epidermal ornithine decarboxylase (ODC) mRNA from an undetectable level in control mice to a high maximum level at 4-5 h after TPA administration. Tetradecanoylphorbol Acetate 60-63 ornithine decarboxylase, structural 1 Mus musculus 155-178 8435870-1 1993 Application of 5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to the skin of female CD-1 mice led to a rapid increase in the concentration of epidermal ornithine decarboxylase (ODC) mRNA from an undetectable level in control mice to a high maximum level at 4-5 h after TPA administration. Tetradecanoylphorbol Acetate 60-63 ornithine decarboxylase, structural 1 Mus musculus 180-183 8435870-5 1993 Intraperitoneal injection of 10 or 30 mumol curcumin 1h before topical application of 5 nmol TPA inhibited TPA-induced increases in epidermal ODC enzyme activity by 75 or 89% respectively. Tetradecanoylphorbol Acetate 107-110 ornithine decarboxylase, structural 1 Mus musculus 142-145 8435870-7 1993 The results indicate that curcumin inhibits TPA-induced increases in epidermal ODC enzyme activity by inhibiting the synthesis and/or enhancing the breakdown of ODC mRNA. Tetradecanoylphorbol Acetate 44-47 ornithine decarboxylase, structural 1 Mus musculus 79-82 8435870-7 1993 The results indicate that curcumin inhibits TPA-induced increases in epidermal ODC enzyme activity by inhibiting the synthesis and/or enhancing the breakdown of ODC mRNA. Tetradecanoylphorbol Acetate 44-47 ornithine decarboxylase, structural 1 Mus musculus 161-164 1520339-3 1992 A single topical application of 12-O-tetradecanoylphorbol-13-acetate induced a much more profound and longer-lasting increase in transgene-derived ornithine decarboxylase activity in comparison with the endogenous enzyme activity. Tetradecanoylphorbol Acetate 32-68 ornithine decarboxylase, structural 1 Mus musculus 147-170 8435870-1 1993 Application of 5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to the skin of female CD-1 mice led to a rapid increase in the concentration of epidermal ornithine decarboxylase (ODC) mRNA from an undetectable level in control mice to a high maximum level at 4-5 h after TPA administration. Tetradecanoylphorbol Acetate 272-275 ornithine decarboxylase, structural 1 Mus musculus 155-178 8435870-1 1993 Application of 5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) to the skin of female CD-1 mice led to a rapid increase in the concentration of epidermal ornithine decarboxylase (ODC) mRNA from an undetectable level in control mice to a high maximum level at 4-5 h after TPA administration. Tetradecanoylphorbol Acetate 272-275 ornithine decarboxylase, structural 1 Mus musculus 180-183 8435870-2 1993 The concentration of epidermal ODC mRNA then decreased rapidly during the next 5 h. The time course for TPA-induced increases in epidermal ODC enzyme activity paralleled very closely the time course for TPA-induced increases in ODC mRNA. Tetradecanoylphorbol Acetate 104-107 ornithine decarboxylase, structural 1 Mus musculus 31-34 8435870-2 1993 The concentration of epidermal ODC mRNA then decreased rapidly during the next 5 h. The time course for TPA-induced increases in epidermal ODC enzyme activity paralleled very closely the time course for TPA-induced increases in ODC mRNA. Tetradecanoylphorbol Acetate 104-107 ornithine decarboxylase, structural 1 Mus musculus 139-142 8435870-2 1993 The concentration of epidermal ODC mRNA then decreased rapidly during the next 5 h. The time course for TPA-induced increases in epidermal ODC enzyme activity paralleled very closely the time course for TPA-induced increases in ODC mRNA. Tetradecanoylphorbol Acetate 104-107 ornithine decarboxylase, structural 1 Mus musculus 139-142 8435870-2 1993 The concentration of epidermal ODC mRNA then decreased rapidly during the next 5 h. The time course for TPA-induced increases in epidermal ODC enzyme activity paralleled very closely the time course for TPA-induced increases in ODC mRNA. Tetradecanoylphorbol Acetate 203-206 ornithine decarboxylase, structural 1 Mus musculus 31-34 8435870-3 1993 Topical administration of 1, 3 or 10 mumol curcumin together with 5 nmol TPA inhibited by 66, 81 and 91% respectively TPA-induced increases in epidermal ODC enzyme activity measured 5 h later. Tetradecanoylphorbol Acetate 73-76 ornithine decarboxylase, structural 1 Mus musculus 153-156 8435870-3 1993 Topical administration of 1, 3 or 10 mumol curcumin together with 5 nmol TPA inhibited by 66, 81 and 91% respectively TPA-induced increases in epidermal ODC enzyme activity measured 5 h later. Tetradecanoylphorbol Acetate 118-121 ornithine decarboxylase, structural 1 Mus musculus 153-156 8435870-4 1993 In a parallel study, TPA-induced increases in the concentration of epidermal ODC mRNA was inhibited by 54, 85 and 82% respectively. Tetradecanoylphorbol Acetate 21-24 ornithine decarboxylase, structural 1 Mus musculus 77-80 8346079-11 1993 However, TPA induction of ornithine decarboxylase activity did not appear to be significantly modified by dietary linoleate. Tetradecanoylphorbol Acetate 9-12 ornithine decarboxylase, structural 1 Mus musculus 26-49 20732145-4 1992 ADR (10 mum) and, to a lesser degree, DAU (5 mum) also enhance 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ODC activity, but, in contrast to ADR, 10-50 mum-DAU inhibit the ODC response to TPA by 50% or more. Tetradecanoylphorbol Acetate 63-99 ornithine decarboxylase, structural 1 Mus musculus 114-117 20732145-4 1992 ADR (10 mum) and, to a lesser degree, DAU (5 mum) also enhance 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ODC activity, but, in contrast to ADR, 10-50 mum-DAU inhibit the ODC response to TPA by 50% or more. Tetradecanoylphorbol Acetate 101-104 ornithine decarboxylase, structural 1 Mus musculus 114-117 20732145-5 1992 The induction and superinduction of ODC activities by ADR and/or TPA are all inhibited by the Ca(2+)-channel blocker verapamil. Tetradecanoylphorbol Acetate 65-68 ornithine decarboxylase, structural 1 Mus musculus 36-39 1385002-1 1992 In previous experiments, pretreatment of CD-1 mouse skin with prostratin (12-deoxyphorbol 13-acetate) inhibited hyperplasia, induction of ornithine decarboxylase and edema in response to acute treatment with phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 208-239 ornithine decarboxylase, structural 1 Mus musculus 138-161 1426027-1 1992 12-O-Tetradecanoylphorbol 13-acetate (TPA), an activator of protein kinase C (PKC), induced ornithine decarboxylase (ODC) in primary cultured mouse epidermal cells. Tetradecanoylphorbol Acetate 0-36 ornithine decarboxylase, structural 1 Mus musculus 92-115 1426027-1 1992 12-O-Tetradecanoylphorbol 13-acetate (TPA), an activator of protein kinase C (PKC), induced ornithine decarboxylase (ODC) in primary cultured mouse epidermal cells. Tetradecanoylphorbol Acetate 0-36 ornithine decarboxylase, structural 1 Mus musculus 117-120 1426027-1 1992 12-O-Tetradecanoylphorbol 13-acetate (TPA), an activator of protein kinase C (PKC), induced ornithine decarboxylase (ODC) in primary cultured mouse epidermal cells. Tetradecanoylphorbol Acetate 38-41 ornithine decarboxylase, structural 1 Mus musculus 92-115 1426027-1 1992 12-O-Tetradecanoylphorbol 13-acetate (TPA), an activator of protein kinase C (PKC), induced ornithine decarboxylase (ODC) in primary cultured mouse epidermal cells. Tetradecanoylphorbol Acetate 38-41 ornithine decarboxylase, structural 1 Mus musculus 117-120 1426027-3 1992 Both TPA- and staurosporine-caused ODC inductions were markedly suppressed in the PKC-down-regulated cells. Tetradecanoylphorbol Acetate 5-8 ornithine decarboxylase, structural 1 Mus musculus 35-38 1315627-6 1992 Copper(II) bis(diisopropylsalicylate) (2 mumol 30 min before BSF), an effective inhibitor of TPA-induced ODC activity and tumor promotion, also had little or no effect on BSF-induced ODC. Tetradecanoylphorbol Acetate 93-96 ornithine decarboxylase, structural 1 Mus musculus 105-108 1617628-6 1992 In the present study we assessed the effect of skin application of GTP to SENCAR mice on 12-O-tetradecanoylphorbol-13-acetate (TPA) and other skin tumor promoter-caused induction of epidermal ornithine decarboxylase (ODC) activity. Tetradecanoylphorbol Acetate 89-125 ornithine decarboxylase, structural 1 Mus musculus 217-220 1617628-7 1992 Topical application of GTP to mouse skin inhibited TPA-induced epidermal ODC activity in a dose-dependent manner. Tetradecanoylphorbol Acetate 51-54 ornithine decarboxylase, structural 1 Mus musculus 73-76 1617628-11 1992 In order to identify which of the specific epicatechin derivatives present in GTP is responsible for these inhibitory effects, they were isolated from GTP and evaluated for their inhibitory effects against TPA-caused induction of epidermal ODC activity. Tetradecanoylphorbol Acetate 206-209 ornithine decarboxylase, structural 1 Mus musculus 240-243 1617628-13 1992 EGCG also showed greater inhibitory effects against TPA-caused induction of epidermal ODC activity when compared with several other naturally occurring polyphenols. Tetradecanoylphorbol Acetate 52-55 ornithine decarboxylase, structural 1 Mus musculus 86-89 1629631-5 1992 ODC activity was elevated in all treatment groups (TPA greater than EPP greater than UVR), with UVR induction returning to near control (acetone) levels by 16 weeks even though the UVR-induced hyperplasia continued to increase at the 16-week point. Tetradecanoylphorbol Acetate 51-54 ornithine decarboxylase, structural 1 Mus musculus 0-3 1315627-7 1992 The work described in this paper suggests that BSF induces epidermal ODC by a very specific mechanism that exhibits both similarities and differences with that of the phorbol ester, TPA. Tetradecanoylphorbol Acetate 182-185 ornithine decarboxylase, structural 1 Mus musculus 69-72 1547524-1 1992 A single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin caused an induction of epidermal ornithine decarboxylase (ODC) activity. Tetradecanoylphorbol Acetate 32-68 ornithine decarboxylase, structural 1 Mus musculus 122-145 1547524-1 1992 A single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin caused an induction of epidermal ornithine decarboxylase (ODC) activity. Tetradecanoylphorbol Acetate 32-68 ornithine decarboxylase, structural 1 Mus musculus 147-150 1547524-1 1992 A single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin caused an induction of epidermal ornithine decarboxylase (ODC) activity. Tetradecanoylphorbol Acetate 70-73 ornithine decarboxylase, structural 1 Mus musculus 122-145 1547524-1 1992 A single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin caused an induction of epidermal ornithine decarboxylase (ODC) activity. Tetradecanoylphorbol Acetate 70-73 ornithine decarboxylase, structural 1 Mus musculus 147-150 1547524-2 1992 When mice were topically pretreated with staurosporine, a most potent protein kinase C inhibitor, 6-84 h prior to TPA treatment, TPA-caused ODC induction was markedly enhanced. Tetradecanoylphorbol Acetate 114-117 ornithine decarboxylase, structural 1 Mus musculus 140-143 1547524-2 1992 When mice were topically pretreated with staurosporine, a most potent protein kinase C inhibitor, 6-84 h prior to TPA treatment, TPA-caused ODC induction was markedly enhanced. Tetradecanoylphorbol Acetate 129-132 ornithine decarboxylase, structural 1 Mus musculus 140-143 1547524-3 1992 The enhancement of TPA-caused ODC induction by staurosporine was most pronounced when the time interval between staurosporine and TPA treatment was 36 h. Staurosporine elicited this enhancing effect in a dose-related manner. Tetradecanoylphorbol Acetate 19-22 ornithine decarboxylase, structural 1 Mus musculus 30-33 1547524-3 1992 The enhancement of TPA-caused ODC induction by staurosporine was most pronounced when the time interval between staurosporine and TPA treatment was 36 h. Staurosporine elicited this enhancing effect in a dose-related manner. Tetradecanoylphorbol Acetate 130-133 ornithine decarboxylase, structural 1 Mus musculus 30-33 1547524-6 1992 Although staurosporine markedly augmented TPA-caused ODC induction, staurosporine-caused ODC induction was not augmented by this compound. Tetradecanoylphorbol Acetate 42-45 ornithine decarboxylase, structural 1 Mus musculus 53-56 1547524-8 1992 These results indicate that the enhancement of ODC induction by staurosporine is specific for the induction caused by TPA and that this enhancing effect is not related to the protein kinase C inhibitory action of staurosporine. Tetradecanoylphorbol Acetate 118-121 ornithine decarboxylase, structural 1 Mus musculus 47-50 1547524-9 1992 TPA-caused epidermal ODC induction was inhibited by indomethacin, and this inhibition was reversed by prostaglandin E2 (PGE2). Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 21-24 1740006-1 1992 Previous work from our laboratory demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) or a synthetic diacylglycerol induced significantly higher epidermal ornithine decarboxylase (ODC) activity in C57BL/6 than in DBA/2 mice. Tetradecanoylphorbol Acetate 52-88 ornithine decarboxylase, structural 1 Mus musculus 164-187 1740006-3 1992 In addition, the ODC induction response in B6D2F1 offspring and BXD recombinant inbred (RI) strains was examined following multiple treatments with TPA. Tetradecanoylphorbol Acetate 148-151 ornithine decarboxylase, structural 1 Mus musculus 17-20 1737059-5 1992 The combination of phorbol myristate acetate (PMA) and ionomycin also stimulated ODC activity in these cells. Tetradecanoylphorbol Acetate 19-44 ornithine decarboxylase, structural 1 Mus musculus 81-84 1737059-5 1992 The combination of phorbol myristate acetate (PMA) and ionomycin also stimulated ODC activity in these cells. Tetradecanoylphorbol Acetate 46-49 ornithine decarboxylase, structural 1 Mus musculus 81-84 1737059-6 1992 The anti-oxidants DES, NDGA and ferricyanide strongly inhibited the increase in ODC activity seen in response to either concanavalin A or PMA/ionomycin. Tetradecanoylphorbol Acetate 138-141 ornithine decarboxylase, structural 1 Mus musculus 80-83 1740006-7 1992 ODC activity induced by multiple application of TPA in B6DF1 mice, whose susceptibility to phorbol ester tumor promotion is inherited as an incomplete dominant trait, was comparable to that induced in C57BL/6 mice at all the doses examined. Tetradecanoylphorbol Acetate 48-51 ornithine decarboxylase, structural 1 Mus musculus 0-3 1740006-8 1992 Cluster analysis of TPA-induced ODC activity in BXD RI strains allowed us tentatively to group them into four or five phenotypes and to estimate a minimum of two genetic loci controlling TPA-induced ODC activity. Tetradecanoylphorbol Acetate 20-23 ornithine decarboxylase, structural 1 Mus musculus 32-35 1740006-1 1992 Previous work from our laboratory demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) or a synthetic diacylglycerol induced significantly higher epidermal ornithine decarboxylase (ODC) activity in C57BL/6 than in DBA/2 mice. Tetradecanoylphorbol Acetate 52-88 ornithine decarboxylase, structural 1 Mus musculus 189-192 1740006-1 1992 Previous work from our laboratory demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) or a synthetic diacylglycerol induced significantly higher epidermal ornithine decarboxylase (ODC) activity in C57BL/6 than in DBA/2 mice. Tetradecanoylphorbol Acetate 90-93 ornithine decarboxylase, structural 1 Mus musculus 164-187 1740006-1 1992 Previous work from our laboratory demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) or a synthetic diacylglycerol induced significantly higher epidermal ornithine decarboxylase (ODC) activity in C57BL/6 than in DBA/2 mice. Tetradecanoylphorbol Acetate 90-93 ornithine decarboxylase, structural 1 Mus musculus 189-192 1909938-3 1991 TPA induced a rapid, yet transient 500- to 1000-fold increase in ornithine decarboxylase (ODC) activity which resulted in a 2- to 8.4-fold elevation of putrescine in both singly or chronically TPA-treated mouse epidermis 4-6 h after its application. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 65-88 1740006-8 1992 Cluster analysis of TPA-induced ODC activity in BXD RI strains allowed us tentatively to group them into four or five phenotypes and to estimate a minimum of two genetic loci controlling TPA-induced ODC activity. Tetradecanoylphorbol Acetate 20-23 ornithine decarboxylase, structural 1 Mus musculus 199-202 1740006-8 1992 Cluster analysis of TPA-induced ODC activity in BXD RI strains allowed us tentatively to group them into four or five phenotypes and to estimate a minimum of two genetic loci controlling TPA-induced ODC activity. Tetradecanoylphorbol Acetate 187-190 ornithine decarboxylase, structural 1 Mus musculus 199-202 1733573-0 1992 Induction of ornithine decarboxylase in specific subpopulations of murine epidermal cells following multiple exposures to 12-O-tetradecanoylphorbol-13-acetate, mezerein and ethyl phenylpropriolate. Tetradecanoylphorbol Acetate 122-158 ornithine decarboxylase, structural 1 Mus musculus 13-36 1733573-1 1992 Single applications of 12-O-tetradecanoylphorbol-13-acetate (TPA), mezerein or ethyl phenylpropriolate (EPP) to mouse skin at appropriate doses cause similar degrees of hyperplasia and comparable levels of induction of epidermal ornithine decarboxylase (ODC) activity. Tetradecanoylphorbol Acetate 23-59 ornithine decarboxylase, structural 1 Mus musculus 229-252 1733573-1 1992 Single applications of 12-O-tetradecanoylphorbol-13-acetate (TPA), mezerein or ethyl phenylpropriolate (EPP) to mouse skin at appropriate doses cause similar degrees of hyperplasia and comparable levels of induction of epidermal ornithine decarboxylase (ODC) activity. Tetradecanoylphorbol Acetate 23-59 ornithine decarboxylase, structural 1 Mus musculus 254-257 1733573-2 1992 Multiple (n = 5) treatments with these agents, in contrast, resulted in large differences in induced ODC activity (TPA much greater than mezerein greater than EPP) with no differences in the degree of hyperplasia or [3H]thymidine pulse-labeling among the multiple treatment groups. Tetradecanoylphorbol Acetate 115-118 ornithine decarboxylase, structural 1 Mus musculus 101-104 1733573-3 1992 To attempt to explain the cellular basis for the greater ODC-inducing ability of TPA relative to mezerein and EPP in chronic exposure protocols, immunocytochemical and flow cytometric analyses were performed. Tetradecanoylphorbol Acetate 81-84 ornithine decarboxylase, structural 1 Mus musculus 57-60 1733573-8 1992 Our results suggest that chronic treatment of murine epidermis with the potent complete tumor promoter TPA leads to the selective expansion of a keratinocyte subpopulation that is hyperinducible for ODC and may be identical to the cells in the perifollicular region previously identified. Tetradecanoylphorbol Acetate 103-106 ornithine decarboxylase, structural 1 Mus musculus 199-202 1913657-0 1991 Prostratin, a nonpromoting phorbol ester, inhibits induction by phorbol 12-myristate 13-acetate of ornithine decarboxylase, edema, and hyperplasia in CD-1 mouse skin. Tetradecanoylphorbol Acetate 64-95 ornithine decarboxylase, structural 1 Mus musculus 99-122 1521167-2 1992 The mechanism of ornithine decarboxylase (ODC) induction by phorbol ester (TPA) has been studied in two permanent epithelial cell lines, a control (Ctr) and a Benzo (a) pyrene transformed line (BaP-tr); the degree of ODC gene expression (ODC-mRNA) was evaluated in comparison to the ODC activity. Tetradecanoylphorbol Acetate 75-78 ornithine decarboxylase, structural 1 Mus musculus 17-40 1521167-2 1992 The mechanism of ornithine decarboxylase (ODC) induction by phorbol ester (TPA) has been studied in two permanent epithelial cell lines, a control (Ctr) and a Benzo (a) pyrene transformed line (BaP-tr); the degree of ODC gene expression (ODC-mRNA) was evaluated in comparison to the ODC activity. Tetradecanoylphorbol Acetate 75-78 ornithine decarboxylase, structural 1 Mus musculus 42-45 1521167-3 1992 A small dose of TPA (4 x 10(-8) M) highly induced ODC activity in these cells. Tetradecanoylphorbol Acetate 16-19 ornithine decarboxylase, structural 1 Mus musculus 50-53 1521167-6 1992 Repetitive TPA treatment decreased the ODC induction in these cells, as compared to that resulting from a single TPA treatment. Tetradecanoylphorbol Acetate 11-14 ornithine decarboxylase, structural 1 Mus musculus 39-42 1521167-14 1992 Studies now in progress suggested that the inhibition of TPA induced ODC by DXME may reflect ODC gene repression, as for the stimulating effect it could be related to ODC post-transcriptional modulation, owing to the decrease of proteolytic action. Tetradecanoylphorbol Acetate 57-60 ornithine decarboxylase, structural 1 Mus musculus 69-72 1521167-14 1992 Studies now in progress suggested that the inhibition of TPA induced ODC by DXME may reflect ODC gene repression, as for the stimulating effect it could be related to ODC post-transcriptional modulation, owing to the decrease of proteolytic action. Tetradecanoylphorbol Acetate 57-60 ornithine decarboxylase, structural 1 Mus musculus 93-96 1521167-14 1992 Studies now in progress suggested that the inhibition of TPA induced ODC by DXME may reflect ODC gene repression, as for the stimulating effect it could be related to ODC post-transcriptional modulation, owing to the decrease of proteolytic action. Tetradecanoylphorbol Acetate 57-60 ornithine decarboxylase, structural 1 Mus musculus 93-96 1408948-6 1992 Similarly, the topical application of EGCG resulted in significant inhibition (p less than 0.005) in TPA-caused induction of epidermal ODC activity. Tetradecanoylphorbol Acetate 101-104 ornithine decarboxylase, structural 1 Mus musculus 135-138 1764695-3 1991 It was observed that TA inhibited TPA induced ODC activity. Tetradecanoylphorbol Acetate 34-37 ornithine decarboxylase, structural 1 Mus musculus 46-49 1909938-3 1991 TPA induced a rapid, yet transient 500- to 1000-fold increase in ornithine decarboxylase (ODC) activity which resulted in a 2- to 8.4-fold elevation of putrescine in both singly or chronically TPA-treated mouse epidermis 4-6 h after its application. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 90-93 1909938-3 1991 TPA induced a rapid, yet transient 500- to 1000-fold increase in ornithine decarboxylase (ODC) activity which resulted in a 2- to 8.4-fold elevation of putrescine in both singly or chronically TPA-treated mouse epidermis 4-6 h after its application. Tetradecanoylphorbol Acetate 193-196 ornithine decarboxylase, structural 1 Mus musculus 65-88 1909938-3 1991 TPA induced a rapid, yet transient 500- to 1000-fold increase in ornithine decarboxylase (ODC) activity which resulted in a 2- to 8.4-fold elevation of putrescine in both singly or chronically TPA-treated mouse epidermis 4-6 h after its application. Tetradecanoylphorbol Acetate 193-196 ornithine decarboxylase, structural 1 Mus musculus 90-93 2032222-1 1991 Naturally occurring plant phenols with antimutagenic and anticarcinogenic activities were tested for their abilities to inhibit the ornithine decarboxylase (ODC) response linked to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 205-241 ornithine decarboxylase, structural 1 Mus musculus 132-155 2032222-1 1991 Naturally occurring plant phenols with antimutagenic and anticarcinogenic activities were tested for their abilities to inhibit the ornithine decarboxylase (ODC) response linked to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 205-241 ornithine decarboxylase, structural 1 Mus musculus 157-160 2032222-1 1991 Naturally occurring plant phenols with antimutagenic and anticarcinogenic activities were tested for their abilities to inhibit the ornithine decarboxylase (ODC) response linked to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 243-246 ornithine decarboxylase, structural 1 Mus musculus 157-160 2032222-2 1991 Topical applications of tannic acid (TA) inhibit remarkably and in a dose-dependent manner TPA-induced ODC activity in mouse epidermis in vivo. Tetradecanoylphorbol Acetate 91-94 ornithine decarboxylase, structural 1 Mus musculus 103-106 2032222-4 1991 The induction of epidermal ODC activity by 8.5 nmol of TPA is inhibited maximally when 20 mumol of TA are applied topically to the skin 20 min before the tumor promoter. Tetradecanoylphorbol Acetate 55-58 ornithine decarboxylase, structural 1 Mus musculus 27-30 2032222-5 1991 Gallic acid and several of its derivatives inhibit the ODC response to TPA to a lesser degree than TA. Tetradecanoylphorbol Acetate 71-74 ornithine decarboxylase, structural 1 Mus musculus 55-58 2032222-7 1991 TA also inhibits the ODC-inducing activities of several structurally different tumor promoters and the greater ODC responses produced by repeated TPA treatments. Tetradecanoylphorbol Acetate 146-149 ornithine decarboxylase, structural 1 Mus musculus 111-114 1991991-2 1991 In this study, we investigated the effect of BHA on the activity of ornithine decarboxylase (ODC, an indicator of tumor promotion) and its gene expression induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in mouse skin. Tetradecanoylphorbol Acetate 205-208 ornithine decarboxylase, structural 1 Mus musculus 68-91 1899810-7 1991 ODC induction caused by TPA was inhibited by a topical application of cyclooxygenase inhibitor, indomethacin. Tetradecanoylphorbol Acetate 24-27 ornithine decarboxylase, structural 1 Mus musculus 0-3 1899810-1 1991 A topical application of a chalcone derivative, 4,2",4"-trihydroxychalcone (isoliquiritigenin) inhibited epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. inflammation, caused by a topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mice. Tetradecanoylphorbol Acetate 234-270 ornithine decarboxylase, structural 1 Mus musculus 140-143 1899810-1 1991 A topical application of a chalcone derivative, 4,2",4"-trihydroxychalcone (isoliquiritigenin) inhibited epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. inflammation, caused by a topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mice. Tetradecanoylphorbol Acetate 272-275 ornithine decarboxylase, structural 1 Mus musculus 140-143 1991991-2 1991 In this study, we investigated the effect of BHA on the activity of ornithine decarboxylase (ODC, an indicator of tumor promotion) and its gene expression induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in mouse skin. Tetradecanoylphorbol Acetate 166-203 ornithine decarboxylase, structural 1 Mus musculus 68-91 1991991-2 1991 In this study, we investigated the effect of BHA on the activity of ornithine decarboxylase (ODC, an indicator of tumor promotion) and its gene expression induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in mouse skin. Tetradecanoylphorbol Acetate 166-203 ornithine decarboxylase, structural 1 Mus musculus 93-96 1991991-3 1991 TPA-induced ODC activity was markedly inhibited by the topical application of 55 mumol of BHA (the inhibition rate at 6 h was about 80%). Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 12-15 1991991-4 1991 In Northern and dot-blot analysis, the TPA-induced increase in ODC mRNA was shown to be markedly reduced by the same dose of BHA (the inhibition rate at 4 h was about 60%). Tetradecanoylphorbol Acetate 39-42 ornithine decarboxylase, structural 1 Mus musculus 63-66 1908616-3 1991 Curcumin is a potent inhibitor of TPA-induced ornithine decarboxylase activity and inflammation in mouse skin whereas chlorogenic acid, caffeic acid and ferulic acid are only weakly active or inactive. Tetradecanoylphorbol Acetate 34-37 ornithine decarboxylase, structural 1 Mus musculus 46-69 1675515-0 1991 Detection of ornithine decarboxylase gene expression in 12-O-tetradecanoylphorbol-13-acetate-treated mouse skin using in situ hybridization. Tetradecanoylphorbol Acetate 56-92 ornithine decarboxylase, structural 1 Mus musculus 13-36 1675515-1 1991 The localization of ornithine decarboxylase gene expression in mouse skin by tumour promoter, 12-O-tetradecanoylphorbol-13-acetate, was investigated using in situ hybridization. Tetradecanoylphorbol Acetate 94-130 ornithine decarboxylase, structural 1 Mus musculus 20-43 1675515-4 1991 These results indicate that the epidermal cells are mainly responsible for the activation of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate. Tetradecanoylphorbol Acetate 120-156 ornithine decarboxylase, structural 1 Mus musculus 93-116 2110512-2 1990 PAMBCu inhibited TPA-caused epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. skin inflammation. Tetradecanoylphorbol Acetate 17-20 ornithine decarboxylase, structural 1 Mus musculus 38-61 1898988-4 1991 Furthermore, application of 5 micrograms TPA to mouse skin rapidly caused accumulation of ornithine decarboxylase (ODC). Tetradecanoylphorbol Acetate 41-44 ornithine decarboxylase, structural 1 Mus musculus 90-113 1898988-4 1991 Furthermore, application of 5 micrograms TPA to mouse skin rapidly caused accumulation of ornithine decarboxylase (ODC). Tetradecanoylphorbol Acetate 41-44 ornithine decarboxylase, structural 1 Mus musculus 115-118 1898988-5 1991 Similarly, sitosterol and lupane-type triterpene derivatives markedly inhibited this TPA-induced ODC accumulation. Tetradecanoylphorbol Acetate 85-88 ornithine decarboxylase, structural 1 Mus musculus 97-100 2118422-0 1990 Ability of the Ca2+ ionophores A23187 and ionomycin to mimic some of the effects of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production, ornithine decarboxylase activity, and DNA synthesis in mouse epidermis in vivo. Tetradecanoylphorbol Acetate 103-139 ornithine decarboxylase, structural 1 Mus musculus 169-192 2118422-2 1990 In contrast, these doses of Ca2+ ionophores applied once or twice at a 48-h interval produce only 3-8% of the 16- or 34-fold inductions of epidermal ornithine decarboxylase (ODC) activities caused by similar TPA treatments. Tetradecanoylphorbol Acetate 208-211 ornithine decarboxylase, structural 1 Mus musculus 174-177 2118422-6 1990 The results suggest that the magnitudes of Ca2+ ionophore- and TPA-induced DNA synthesis may be linked to HPx production rather than ODC induction. Tetradecanoylphorbol Acetate 63-66 ornithine decarboxylase, structural 1 Mus musculus 133-136 2226643-2 1990 In HEL-30 cells, protein kinase C activation is followed by ornithine decarboxylase stimulation and cell proliferation, events inhibited by H-7, a specific inhibitor of protein kinase C. TPA in NCTC cells inhibited the basal ornithine decarboxylase activity and cell growth, whereas H-7 did not modify TPA effect. Tetradecanoylphorbol Acetate 187-190 ornithine decarboxylase, structural 1 Mus musculus 60-83 2226643-2 1990 In HEL-30 cells, protein kinase C activation is followed by ornithine decarboxylase stimulation and cell proliferation, events inhibited by H-7, a specific inhibitor of protein kinase C. TPA in NCTC cells inhibited the basal ornithine decarboxylase activity and cell growth, whereas H-7 did not modify TPA effect. Tetradecanoylphorbol Acetate 187-190 ornithine decarboxylase, structural 1 Mus musculus 225-248 2401054-9 1990 In a parallel study, ornithine decarboxylase activity, a suggested marker of promotion, was greatly elevated in the epidermis of all TPA-treated mice and the effect of diet tended to reflect the different rates of tumor formation observed among the groups. Tetradecanoylphorbol Acetate 133-136 ornithine decarboxylase, structural 1 Mus musculus 21-44 2369749-1 1990 Ornithine decarboxylase (ODC), the initial enzyme in the polyamine biosynthetic pathway, has been used as a marker for the hyperplasia that occurs following exposure of mouse epidermis to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 207-243 ornithine decarboxylase, structural 1 Mus musculus 0-23 2369749-1 1990 Ornithine decarboxylase (ODC), the initial enzyme in the polyamine biosynthetic pathway, has been used as a marker for the hyperplasia that occurs following exposure of mouse epidermis to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 207-243 ornithine decarboxylase, structural 1 Mus musculus 25-28 2369749-1 1990 Ornithine decarboxylase (ODC), the initial enzyme in the polyamine biosynthetic pathway, has been used as a marker for the hyperplasia that occurs following exposure of mouse epidermis to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 245-248 ornithine decarboxylase, structural 1 Mus musculus 0-23 2369749-1 1990 Ornithine decarboxylase (ODC), the initial enzyme in the polyamine biosynthetic pathway, has been used as a marker for the hyperplasia that occurs following exposure of mouse epidermis to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 245-248 ornithine decarboxylase, structural 1 Mus musculus 25-28 2369749-3 1990 Basal levels of ODC-specific antibody binding were detectable in acetone-treated CD-1 mouse epidermis and were increased 3-fold at 4 h after TPA treatment. Tetradecanoylphorbol Acetate 141-144 ornithine decarboxylase, structural 1 Mus musculus 16-19 2369749-4 1990 The amount of ODC antibody binding detected after exposure to 17 nmol TPA twice weekly for 3 weeks was similar to that detected within cells isolated from papillomas and was 2.5-fold higher than in cells isolated at 4 h after a single topical treatment of mice with TPA. Tetradecanoylphorbol Acetate 70-73 ornithine decarboxylase, structural 1 Mus musculus 14-17 2369749-4 1990 The amount of ODC antibody binding detected after exposure to 17 nmol TPA twice weekly for 3 weeks was similar to that detected within cells isolated from papillomas and was 2.5-fold higher than in cells isolated at 4 h after a single topical treatment of mice with TPA. Tetradecanoylphorbol Acetate 266-269 ornithine decarboxylase, structural 1 Mus musculus 14-17 2369749-5 1990 These observations support the hypothesis that specific subpopulations of keratinocytes constitutively express high levels of ODC following chronic exposure to TPA. Tetradecanoylphorbol Acetate 160-163 ornithine decarboxylase, structural 1 Mus musculus 126-129 2110512-2 1990 PAMBCu inhibited TPA-caused epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. skin inflammation. Tetradecanoylphorbol Acetate 17-20 ornithine decarboxylase, structural 1 Mus musculus 63-66 2819717-2 1989 The epidermis from SSIN mice treated with a single application of 12-O-tetradecanoylphorbol-13-acetate (TPA) displayed a large induction of ODC and a subsequent extensive hyperplasia. Tetradecanoylphorbol Acetate 66-102 ornithine decarboxylase, structural 1 Mus musculus 140-143 2105157-2 1990 Apigenin was a potent inhibitor of epidermal ornithine decarboxylase induction by TPA in a dose-dependent manner from 1 to 20 mumol. Tetradecanoylphorbol Acetate 82-85 ornithine decarboxylase, structural 1 Mus musculus 45-68 22760862-4 2013 The GOH treatment also resulted in reduction of TPA-induced ornithine decarboxylase activity and [(3) H] thymidine incorporation by 53% (P < 0.001) and 41% (P < 0.001), respectively. Tetradecanoylphorbol Acetate 48-51 ornithine decarboxylase, structural 1 Mus musculus 60-83 7818761-1 1995 This study was undertaken to assess the effects of a single or two sequential topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of c-fos, c-jun, junB, c-myc, and ornithine decarboxylase (ODC) in promotion-sensitive SSIN mice and the relatively promotion-resistant C57BL/6 strain. Tetradecanoylphorbol Acetate 102-138 ornithine decarboxylase, structural 1 Mus musculus 197-220 7818761-1 1995 This study was undertaken to assess the effects of a single or two sequential topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of c-fos, c-jun, junB, c-myc, and ornithine decarboxylase (ODC) in promotion-sensitive SSIN mice and the relatively promotion-resistant C57BL/6 strain. Tetradecanoylphorbol Acetate 102-138 ornithine decarboxylase, structural 1 Mus musculus 222-225 7818761-1 1995 This study was undertaken to assess the effects of a single or two sequential topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of c-fos, c-jun, junB, c-myc, and ornithine decarboxylase (ODC) in promotion-sensitive SSIN mice and the relatively promotion-resistant C57BL/6 strain. Tetradecanoylphorbol Acetate 140-143 ornithine decarboxylase, structural 1 Mus musculus 197-220 7818761-1 1995 This study was undertaken to assess the effects of a single or two sequential topical applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the expression of c-fos, c-jun, junB, c-myc, and ornithine decarboxylase (ODC) in promotion-sensitive SSIN mice and the relatively promotion-resistant C57BL/6 strain. Tetradecanoylphorbol Acetate 140-143 ornithine decarboxylase, structural 1 Mus musculus 222-225 7818761-2 1995 Northern blot analysis demonstrated that a single promoting dose of TPA induced ODC mRNA expression 10- to 15-fold in both strains. Tetradecanoylphorbol Acetate 68-71 ornithine decarboxylase, structural 1 Mus musculus 80-83 7818761-3 1995 Treatment of each strain with a second dose of TPA, 48 h (in C57BL/6 mice) or 72 h (in SSIN mice) after the first, led to hyperinduction of ODC activity. Tetradecanoylphorbol Acetate 47-50 ornithine decarboxylase, structural 1 Mus musculus 140-143 2819717-2 1989 The epidermis from SSIN mice treated with a single application of 12-O-tetradecanoylphorbol-13-acetate (TPA) displayed a large induction of ODC and a subsequent extensive hyperplasia. Tetradecanoylphorbol Acetate 104-107 ornithine decarboxylase, structural 1 Mus musculus 140-143 2819717-5 1989 The epidermis of C57BL/6J responds to a single application of TPA with a level of ODC induction similar to that of the SSIN mice. Tetradecanoylphorbol Acetate 62-65 ornithine decarboxylase, structural 1 Mus musculus 82-85 2819717-10 1989 It is concluded that, while hyperplasia remains an apparent requirement for tumor promotion, the ODC induction following an initial TPA treatment is insufficient for or not causally related to this hyperplasia. Tetradecanoylphorbol Acetate 132-135 ornithine decarboxylase, structural 1 Mus musculus 97-100 2509065-6 1989 Several discrepancies are observed between the hydroperoxide response to TPA and the known effects of the tumor promoter on ornithine decarboxylase (ODC) induction. Tetradecanoylphorbol Acetate 73-76 ornithine decarboxylase, structural 1 Mus musculus 149-152 2602143-0 1989 Regulation of mouse ornithine decarboxylase activity by cell growth, serum and tetradecanoyl phorbol acetate is governed primarily by sequences within the coding region of the gene. Tetradecanoylphorbol Acetate 79-108 ornithine decarboxylase, structural 1 Mus musculus 20-43 2602143-1 1989 To determine the genetic elements required for modulation of ornithine decarboxylase (ODC) activity in response to cell growth or treatment with serum or with tetradecanoyl phorbol acetate, ODC-deficient cells were transfected with a series of recombinant DNAs encoding mouse ODC. Tetradecanoylphorbol Acetate 159-188 ornithine decarboxylase, structural 1 Mus musculus 61-84 2602143-1 1989 To determine the genetic elements required for modulation of ornithine decarboxylase (ODC) activity in response to cell growth or treatment with serum or with tetradecanoyl phorbol acetate, ODC-deficient cells were transfected with a series of recombinant DNAs encoding mouse ODC. Tetradecanoylphorbol Acetate 159-188 ornithine decarboxylase, structural 1 Mus musculus 86-89 2591024-7 1989 Additionally, on this dosing regimen, the peak of ODC activity shifted to approximately 4 h after the last treatment, so that the time-course of ODC induction resembled that after multiple applications of TPA. Tetradecanoylphorbol Acetate 205-208 ornithine decarboxylase, structural 1 Mus musculus 50-53 2591024-7 1989 Additionally, on this dosing regimen, the peak of ODC activity shifted to approximately 4 h after the last treatment, so that the time-course of ODC induction resembled that after multiple applications of TPA. Tetradecanoylphorbol Acetate 205-208 ornithine decarboxylase, structural 1 Mus musculus 145-148 2601687-1 1989 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells. Tetradecanoylphorbol Acetate 0-36 ornithine decarboxylase, structural 1 Mus musculus 51-74 2601687-1 1989 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells. Tetradecanoylphorbol Acetate 0-36 ornithine decarboxylase, structural 1 Mus musculus 76-79 2601687-1 1989 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells. Tetradecanoylphorbol Acetate 38-41 ornithine decarboxylase, structural 1 Mus musculus 51-74 2601687-1 1989 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells. Tetradecanoylphorbol Acetate 38-41 ornithine decarboxylase, structural 1 Mus musculus 76-79 2601687-2 1989 TPA (30 nM)-caused ODC induction was almost completely blocked by 30 microM H-7 [1-(5-isoquinolinylsulfonyl)-2-methylpiperazine], a well known protein kinase C inhibitor, but the same concentration of H-7 failed to restore the 125I-EGF binding suppressed by TPA (10 nM). Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 19-22 2601687-2 1989 TPA (30 nM)-caused ODC induction was almost completely blocked by 30 microM H-7 [1-(5-isoquinolinylsulfonyl)-2-methylpiperazine], a well known protein kinase C inhibitor, but the same concentration of H-7 failed to restore the 125I-EGF binding suppressed by TPA (10 nM). Tetradecanoylphorbol Acetate 258-261 ornithine decarboxylase, structural 1 Mus musculus 19-22 2601687-3 1989 On the other hand, sphingosine, another protein kinase C inhibitor, blocked not only TPA-caused ODC induction but also TPA-caused suppression of 125I-EGF binding. Tetradecanoylphorbol Acetate 85-88 ornithine decarboxylase, structural 1 Mus musculus 96-99 2509065-7 1989 In contrast to the refractory state against ODC induction caused by TPA treatments repeated at intervals of less than 48 h, the time interval required for recovery of the hydroperoxide response to TPA in TPA-pretreated skins is only 5 h. The stimulatory effects of A23187, ionomycin and various diacylglycerols (DAGs) on hydroperoxide production do not correlate with their ODC-inducing activities. Tetradecanoylphorbol Acetate 68-71 ornithine decarboxylase, structural 1 Mus musculus 44-47 2509065-7 1989 In contrast to the refractory state against ODC induction caused by TPA treatments repeated at intervals of less than 48 h, the time interval required for recovery of the hydroperoxide response to TPA in TPA-pretreated skins is only 5 h. The stimulatory effects of A23187, ionomycin and various diacylglycerols (DAGs) on hydroperoxide production do not correlate with their ODC-inducing activities. Tetradecanoylphorbol Acetate 197-200 ornithine decarboxylase, structural 1 Mus musculus 374-377 2509065-7 1989 In contrast to the refractory state against ODC induction caused by TPA treatments repeated at intervals of less than 48 h, the time interval required for recovery of the hydroperoxide response to TPA in TPA-pretreated skins is only 5 h. The stimulatory effects of A23187, ionomycin and various diacylglycerols (DAGs) on hydroperoxide production do not correlate with their ODC-inducing activities. Tetradecanoylphorbol Acetate 197-200 ornithine decarboxylase, structural 1 Mus musculus 374-377 2509065-9 1989 alpha-Difluoromethylornithine (DFMO) and other inhibitors of TPA-induced ODC activity fail to alter hydroperoxide production whereas the compounds that inhibit the hydroperoxide response to TPA, such as fluocinolone acetonide, have no or only minimal inhibitory activity against ODC induction. Tetradecanoylphorbol Acetate 61-64 ornithine decarboxylase, structural 1 Mus musculus 73-76 2509065-9 1989 alpha-Difluoromethylornithine (DFMO) and other inhibitors of TPA-induced ODC activity fail to alter hydroperoxide production whereas the compounds that inhibit the hydroperoxide response to TPA, such as fluocinolone acetonide, have no or only minimal inhibitory activity against ODC induction. Tetradecanoylphorbol Acetate 61-64 ornithine decarboxylase, structural 1 Mus musculus 279-282 2509065-12 1989 Populations of TPA-treated keratinocytes, therefore, may be responsible not only for ODC activation but also for hydroperoxide production. Tetradecanoylphorbol Acetate 15-18 ornithine decarboxylase, structural 1 Mus musculus 85-88 2547133-12 1989 TPA-induced ornithine decarboxylase (ODC) was significantly higher in AA-treated cultures compared to EPA-treated cultures. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 12-35 2553289-8 1989 These results indicate that a mechanism susceptible to lipoxygenase inhibitors plays a role not only in the TPA-caused but also in the BrMBA-caused epidermal ODC induction, skin inflammation and tumor promotion. Tetradecanoylphorbol Acetate 108-111 ornithine decarboxylase, structural 1 Mus musculus 158-161 2570112-8 1989 Optimal doses of CsA inhibited TPA-induced ODC activity, TGase activity, arachidonic acid release, and interleukin-1 beta (IL-1 beta) mRNA to the same degree (approximately 80%), despite measurement at widely different times (30 min-12 h) required to obtain maximal induction by TPA. Tetradecanoylphorbol Acetate 31-34 ornithine decarboxylase, structural 1 Mus musculus 43-46 2544313-9 1989 TPA-caused epidermal ornithine decarboxylase (ODC) induction was not inhibited by staurosporine but rather augmented by this agent. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 21-44 2544313-9 1989 TPA-caused epidermal ornithine decarboxylase (ODC) induction was not inhibited by staurosporine but rather augmented by this agent. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 46-49 2544313-13 1989 It is possible that TPA induces inflammation, ODC activity, epidermal hyperplasia and tumor promotion through the activation of different type(s) of protein kinase C and staurosporine inhibits only certain type(s) of protein kinase C. Another possible explanation is that the protein kinase C inhibition by staurosporine depends on the nature of the substrate proteins or the intracellular localization of the enzyme. Tetradecanoylphorbol Acetate 20-23 ornithine decarboxylase, structural 1 Mus musculus 46-49 2706740-10 1989 After topical treatment with TPA, C57BL/6 demonstrated an unexpected 2- and 4-fold increase in ODC activity over CD-1 and DBA/2 mice. Tetradecanoylphorbol Acetate 29-32 ornithine decarboxylase, structural 1 Mus musculus 95-98 2706740-12 1989 Thus, the resistant strain (C57BL/6) demonstrated a "hyperinducibility" of epidermal ODC activity by TPA or DiC8. Tetradecanoylphorbol Acetate 101-104 ornithine decarboxylase, structural 1 Mus musculus 85-88 2547133-12 1989 TPA-induced ornithine decarboxylase (ODC) was significantly higher in AA-treated cultures compared to EPA-treated cultures. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 37-40 2702729-3 1989 In DXME-protected skin, the hyperplastic stage was delayed; unexpectedly, before that stage, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced strongly ODC activity in the epidermal cell layer. Tetradecanoylphorbol Acetate 93-130 ornithine decarboxylase, structural 1 Mus musculus 154-157 2702729-3 1989 In DXME-protected skin, the hyperplastic stage was delayed; unexpectedly, before that stage, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced strongly ODC activity in the epidermal cell layer. Tetradecanoylphorbol Acetate 132-135 ornithine decarboxylase, structural 1 Mus musculus 154-157 2702729-4 1989 Provided that the proliferation process was induced, epidermal cells were increasingly sensitive toward TPA action; they may have been less dependent on inflammatory factors which may modulate the induction of ODC. Tetradecanoylphorbol Acetate 104-107 ornithine decarboxylase, structural 1 Mus musculus 210-213 2912589-0 1989 Inhibition of the induction of ornithine decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate in mouse skin by sphingosine sulfate. Tetradecanoylphorbol Acetate 67-103 ornithine decarboxylase, structural 1 Mus musculus 31-54 2912589-1 1989 We investigated the effect of sphingosine sulfate on the induction of ODC (ornithine decarboxylase) activity by TPA (12-O-tetradecanoylphorbol-13-acetate) in mouse skin. Tetradecanoylphorbol Acetate 112-115 ornithine decarboxylase, structural 1 Mus musculus 70-73 2912589-1 1989 We investigated the effect of sphingosine sulfate on the induction of ODC (ornithine decarboxylase) activity by TPA (12-O-tetradecanoylphorbol-13-acetate) in mouse skin. Tetradecanoylphorbol Acetate 112-115 ornithine decarboxylase, structural 1 Mus musculus 75-98 2912589-1 1989 We investigated the effect of sphingosine sulfate on the induction of ODC (ornithine decarboxylase) activity by TPA (12-O-tetradecanoylphorbol-13-acetate) in mouse skin. Tetradecanoylphorbol Acetate 117-153 ornithine decarboxylase, structural 1 Mus musculus 70-73 2912589-1 1989 We investigated the effect of sphingosine sulfate on the induction of ODC (ornithine decarboxylase) activity by TPA (12-O-tetradecanoylphorbol-13-acetate) in mouse skin. Tetradecanoylphorbol Acetate 117-153 ornithine decarboxylase, structural 1 Mus musculus 75-98 2492471-2 1989 TPA induces also an increase of ornithine decarboxylase (ODC) activity and elevates the intracellular concentrations of putrescine and polyamines within 4-8 h. A similar increase of intracellular putrescine and polyamine concentrations can be achieved by administration of 2 mM putrescine to the culture medium. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 32-55 2912589-3 1989 Significant inhibition of TPA-induced ODC activity was observed at 4, 6 and 8 h after TPA treatment in separate studies. Tetradecanoylphorbol Acetate 26-29 ornithine decarboxylase, structural 1 Mus musculus 38-41 2492471-2 1989 TPA induces also an increase of ornithine decarboxylase (ODC) activity and elevates the intracellular concentrations of putrescine and polyamines within 4-8 h. A similar increase of intracellular putrescine and polyamine concentrations can be achieved by administration of 2 mM putrescine to the culture medium. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 57-60 2912589-3 1989 Significant inhibition of TPA-induced ODC activity was observed at 4, 6 and 8 h after TPA treatment in separate studies. Tetradecanoylphorbol Acetate 86-89 ornithine decarboxylase, structural 1 Mus musculus 38-41 2492471-4 1989 Putrescine has rather a counter-regulatory effect as concluded from the observation that the TPA-induced TCGF production and IL-2-specific mRNA expression are augmented (superinduced) by the ODC inhibitor D,L-alpha-difluoromethylornithine (DFMO) and again suppressed after the administration of putrescine or polyamines to DFMO-treated cultures. Tetradecanoylphorbol Acetate 93-96 ornithine decarboxylase, structural 1 Mus musculus 191-194 2912589-4 1989 The results indicate that sphingosine sulfate is an effective inhibitor of ODC induction by TPA in mouse skin. Tetradecanoylphorbol Acetate 92-95 ornithine decarboxylase, structural 1 Mus musculus 75-78 2498558-3 1989 TPA-caused responses in mouse skin such as skin tumor promotion, epidermal ornithine decarboxylase (ODC) induction and skin inflammation were inhibited by various lipoxygenase inhibitors of the arachidonic acid cascade. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 75-98 2498558-3 1989 TPA-caused responses in mouse skin such as skin tumor promotion, epidermal ornithine decarboxylase (ODC) induction and skin inflammation were inhibited by various lipoxygenase inhibitors of the arachidonic acid cascade. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 100-103 2498558-4 1989 Lipoxygenase inhibitors also inhibited TPA-caused ODC induction in isolated epidermal cells or cultured epidermal cells. Tetradecanoylphorbol Acetate 39-42 ornithine decarboxylase, structural 1 Mus musculus 50-53 3196353-1 1988 When applied 5 min either before or after treatment with TPA, 1 microgram of staurosporine cause about 56% inhibition of ODC-induction by 5 micrograms of TPA. Tetradecanoylphorbol Acetate 57-60 ornithine decarboxylase, structural 1 Mus musculus 121-124 2498558-5 1989 Therefore, it is possible that these drugs inhibit TPA-caused ODC induction in mouse skin by directly acting on epidermal cells. Tetradecanoylphorbol Acetate 51-54 ornithine decarboxylase, structural 1 Mus musculus 62-65 20702295-3 1989 At the non-toxic level of 250 mum, CuSO(4) inhibited by 40% the induction of ornithine decarboxylase by TPA in murine epidermal cultures. Tetradecanoylphorbol Acetate 104-107 ornithine decarboxylase, structural 1 Mus musculus 77-100 20702295-7 1989 It appears that oxidants generated in response to TPA partially mediate the induction of ornithine decarboxylase and to a lesser extent DNA synthesis. Tetradecanoylphorbol Acetate 50-53 ornithine decarboxylase, structural 1 Mus musculus 89-112 20837424-3 1989 At 100 mum-palmitoylcarnitine inhibited TPA-induced ODC by 50% and phospholipase C-induced ODC by 95%. Tetradecanoylphorbol Acetate 40-43 ornithine decarboxylase, structural 1 Mus musculus 52-55 3191479-5 1988 Similarly, citral treatment decreased the ability of retinol, but not of retinoic acid, to inhibit the induction of epidermal ornithine decarboxylase activity by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Tetradecanoylphorbol Acetate 181-217 ornithine decarboxylase, structural 1 Mus musculus 126-149 3191479-6 1988 Although citral had little effect on epidermal ornithine decarboxylase activity when applied alone, it potentiated the induction of ornithine decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate. Tetradecanoylphorbol Acetate 168-204 ornithine decarboxylase, structural 1 Mus musculus 132-155 3191479-8 1988 Furthermore, the ability of citral to potentiate the induction of ornithine decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate suggests that modulation of the retinol oxidation pathway by such agents may enhance susceptibility to tumor promoters. Tetradecanoylphorbol Acetate 102-138 ornithine decarboxylase, structural 1 Mus musculus 66-89 3196353-1 1988 When applied 5 min either before or after treatment with TPA, 1 microgram of staurosporine cause about 56% inhibition of ODC-induction by 5 micrograms of TPA. Tetradecanoylphorbol Acetate 154-157 ornithine decarboxylase, structural 1 Mus musculus 121-124 2845222-7 1988 The relevance of oxidant production to the tumor promotion process is suggested by the ability of exogenous xanthine/xanthine oxidase, a superoxide anion-generating system, to induce ornithine decarboxylase, a characteristic of TPA-treated cells. Tetradecanoylphorbol Acetate 228-231 ornithine decarboxylase, structural 1 Mus musculus 183-206 3139287-1 1988 The effects of topically applied curcumin, chlorogenic acid, caffeic acid, and ferulic acid on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced epidermal ornithine decarboxylase activity, epidermal DNA synthesis, and the promotion of skin tumors were evaluated in female CD-1 mice. Tetradecanoylphorbol Acetate 133-136 ornithine decarboxylase, structural 1 Mus musculus 156-179 3139287-2 1988 Topical application of 0.5, 1, 3, or 10 mumol of curcumin inhibited by 31, 46, 84, or 98%, respectively, the induction of epidermal ornithine decarboxylase activity by 5 nmol of TPA. Tetradecanoylphorbol Acetate 178-181 ornithine decarboxylase, structural 1 Mus musculus 132-155 3139287-3 1988 In an additional study, the topical application of 10 mumol of curcumin, chlorogenic acid, caffeic acid, or ferulic acid inhibited by 91, 25, 42, or 46%, respectively, the induction of ornithine decarboxylase activity by 5 nmol of TPA. Tetradecanoylphorbol Acetate 231-234 ornithine decarboxylase, structural 1 Mus musculus 185-208 3141077-1 1988 Recent work from this laboratory has demonstrated the presence of a structurally and functionally different ornithine decarboxylase (ODC) in mouse epidermal tumors induced by a two-stage protocol involving initiation with 7,12-dimethylbenzanthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 276-312 ornithine decarboxylase, structural 1 Mus musculus 108-131 3141077-1 1988 Recent work from this laboratory has demonstrated the presence of a structurally and functionally different ornithine decarboxylase (ODC) in mouse epidermal tumors induced by a two-stage protocol involving initiation with 7,12-dimethylbenzanthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 276-312 ornithine decarboxylase, structural 1 Mus musculus 133-136 3141077-1 1988 Recent work from this laboratory has demonstrated the presence of a structurally and functionally different ornithine decarboxylase (ODC) in mouse epidermal tumors induced by a two-stage protocol involving initiation with 7,12-dimethylbenzanthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 314-317 ornithine decarboxylase, structural 1 Mus musculus 108-131 3179309-2 1988 In BALB/c 3T3 preadipose cells, TPA has previously been shown to rapidly inhibit Na+K+Cl- -cotransport activity, stimulate 2-deoxyglucose uptake and induce ornithine decarboxylase activity. Tetradecanoylphorbol Acetate 32-35 ornithine decarboxylase, structural 1 Mus musculus 156-179 3141077-1 1988 Recent work from this laboratory has demonstrated the presence of a structurally and functionally different ornithine decarboxylase (ODC) in mouse epidermal tumors induced by a two-stage protocol involving initiation with 7,12-dimethylbenzanthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 314-317 ornithine decarboxylase, structural 1 Mus musculus 133-136 3411820-6 1988 A topical application of TPA to the skin caused epidermal ODC induction in all of these strains of mice. Tetradecanoylphorbol Acetate 25-28 ornithine decarboxylase, structural 1 Mus musculus 58-61 3365842-1 1988 Hyperplasiogenic and tumor-promoting phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate or 12-O-retinoylphorbol-13-acetate induce the sequential transient expression of the proto-oncogenes c-fos and c-myc and the ornithine decarboxylase gene in mouse skin in vivo. Tetradecanoylphorbol Acetate 60-96 ornithine decarboxylase, structural 1 Mus musculus 222-245 3411820-8 1988 Maximal induction of epidermal ODC by TPA was also highest in C57BL/6 mice among these three strains of mice. Tetradecanoylphorbol Acetate 38-41 ornithine decarboxylase, structural 1 Mus musculus 31-34 3411820-9 1988 These results indicate that the mechanism of the difference in susceptibility of C57BL/6, CD-1 and SENCAR mice to the tumor-promoting action TPA resides in a step distal to or other than the protein kinase C activation and ODC induction. Tetradecanoylphorbol Acetate 141-144 ornithine decarboxylase, structural 1 Mus musculus 223-226 3349487-0 1988 Inhibition of tumor promoter 12-O-tetradecanoylphorbol-13-acetate-induced synthesis of epidermal ornithine decarboxylase messenger RNA and diacylglycerol-promoted mouse skin tumor formation by retinoic acid. Tetradecanoylphorbol Acetate 29-65 ornithine decarboxylase, structural 1 Mus musculus 97-120 3349487-1 1988 Evidence is presented that inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC; EC 4.1.1.17) by retinoic acid may involve inhibition of protein kinase C-mediated synthesis of ODC mRNA. Tetradecanoylphorbol Acetate 41-77 ornithine decarboxylase, structural 1 Mus musculus 92-115 3349487-1 1988 Evidence is presented that inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC; EC 4.1.1.17) by retinoic acid may involve inhibition of protein kinase C-mediated synthesis of ODC mRNA. Tetradecanoylphorbol Acetate 41-77 ornithine decarboxylase, structural 1 Mus musculus 117-120 3349487-1 1988 Evidence is presented that inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC; EC 4.1.1.17) by retinoic acid may involve inhibition of protein kinase C-mediated synthesis of ODC mRNA. Tetradecanoylphorbol Acetate 41-77 ornithine decarboxylase, structural 1 Mus musculus 217-220 3349487-1 1988 Evidence is presented that inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC; EC 4.1.1.17) by retinoic acid may involve inhibition of protein kinase C-mediated synthesis of ODC mRNA. Tetradecanoylphorbol Acetate 79-82 ornithine decarboxylase, structural 1 Mus musculus 92-115 3349487-1 1988 Evidence is presented that inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC; EC 4.1.1.17) by retinoic acid may involve inhibition of protein kinase C-mediated synthesis of ODC mRNA. Tetradecanoylphorbol Acetate 79-82 ornithine decarboxylase, structural 1 Mus musculus 117-120 3349487-1 1988 Evidence is presented that inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC; EC 4.1.1.17) by retinoic acid may involve inhibition of protein kinase C-mediated synthesis of ODC mRNA. Tetradecanoylphorbol Acetate 79-82 ornithine decarboxylase, structural 1 Mus musculus 217-220 3349487-2 1988 A single application of 10 nmol of TPA to intact mouse skin led to an increase in the steady state levels of epidermal ODC mRNA; a maximal level of ODC mRNA occurred at about 3.5 h after TPA treatment. Tetradecanoylphorbol Acetate 35-38 ornithine decarboxylase, structural 1 Mus musculus 119-122 3349487-2 1988 A single application of 10 nmol of TPA to intact mouse skin led to an increase in the steady state levels of epidermal ODC mRNA; a maximal level of ODC mRNA occurred at about 3.5 h after TPA treatment. Tetradecanoylphorbol Acetate 35-38 ornithine decarboxylase, structural 1 Mus musculus 148-151 3349487-3 1988 TPA-induced increase in ODC mRNA preceded the increase in epidermal ODC activity. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 24-27 3349487-3 1988 TPA-induced increase in ODC mRNA preceded the increase in epidermal ODC activity. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 68-71 3349487-4 1988 Application of 17 nmol of retinoic acid 1 h before application of TPA to mouse skin inhibited the induction of both ODC mRNA and ODC activity. Tetradecanoylphorbol Acetate 66-69 ornithine decarboxylase, structural 1 Mus musculus 116-119 3349487-4 1988 Application of 17 nmol of retinoic acid 1 h before application of TPA to mouse skin inhibited the induction of both ODC mRNA and ODC activity. Tetradecanoylphorbol Acetate 66-69 ornithine decarboxylase, structural 1 Mus musculus 129-132 3349487-5 1988 Using the DNA-excess filter hybridization technique, we found that TPA-increased steady state levels of ODC mRNA in primary culture of newborn mouse epidermal cells were the result of enhanced accumulation of newly synthesized ODC mRNA. Tetradecanoylphorbol Acetate 67-70 ornithine decarboxylase, structural 1 Mus musculus 104-107 3349487-5 1988 Using the DNA-excess filter hybridization technique, we found that TPA-increased steady state levels of ODC mRNA in primary culture of newborn mouse epidermal cells were the result of enhanced accumulation of newly synthesized ODC mRNA. Tetradecanoylphorbol Acetate 67-70 ornithine decarboxylase, structural 1 Mus musculus 227-230 3349487-7 1988 Exposure of primary cultures of newborn epidermal cells to retinoic acid, in conjunction with TPA, inhibited the synthesis of ODC mRNA and failed to alter the half-life of ODC mRNA. Tetradecanoylphorbol Acetate 94-97 ornithine decarboxylase, structural 1 Mus musculus 126-129 3349487-8 1988 These results implicate the role of transcription activation in TPA-induced ODC gene expression and indicate that retinoic acid may inhibit TPA-induced ODC gene transcription. Tetradecanoylphorbol Acetate 64-67 ornithine decarboxylase, structural 1 Mus musculus 76-79 3349487-8 1988 These results implicate the role of transcription activation in TPA-induced ODC gene expression and indicate that retinoic acid may inhibit TPA-induced ODC gene transcription. Tetradecanoylphorbol Acetate 140-143 ornithine decarboxylase, structural 1 Mus musculus 152-155 3349487-11 1988 Taken together, one may conclude that the mechanism of inhibition of TPA-induced ODC by retinoic acid may involve the inhibition of protein kinase C-mediated accumulation of newly synthesized ODC mRNA. Tetradecanoylphorbol Acetate 69-72 ornithine decarboxylase, structural 1 Mus musculus 81-84 3349487-11 1988 Taken together, one may conclude that the mechanism of inhibition of TPA-induced ODC by retinoic acid may involve the inhibition of protein kinase C-mediated accumulation of newly synthesized ODC mRNA. Tetradecanoylphorbol Acetate 69-72 ornithine decarboxylase, structural 1 Mus musculus 192-195 3365770-11 1988 To determine if the mechanism by which PMA or fresh serum altered intracellular glutathione and ODC activity was through the generation of oxygen radicals, EL4 cells were cultured with free radical scavengers. Tetradecanoylphorbol Acetate 39-42 ornithine decarboxylase, structural 1 Mus musculus 96-99 3411820-7 1988 At any doses of TPA, TPA-induced epidermal ODC activity of C57BL/6 mice was always higher than those of SENCAR and CD-1 mice. Tetradecanoylphorbol Acetate 16-19 ornithine decarboxylase, structural 1 Mus musculus 43-46 3411820-7 1988 At any doses of TPA, TPA-induced epidermal ODC activity of C57BL/6 mice was always higher than those of SENCAR and CD-1 mice. Tetradecanoylphorbol Acetate 21-24 ornithine decarboxylase, structural 1 Mus musculus 43-46 2832424-9 1988 The induction of ODC mRNA by either LPS or TPA was blocked by the addition of cycloheximide (25 micrograms/ml) or anisomycin (0.1 mM) to the cellular incubation mixture. Tetradecanoylphorbol Acetate 43-46 ornithine decarboxylase, structural 1 Mus musculus 17-20 2832424-10 1988 This indicated that protein synthesis was required as a prerequisite to LPS or TPA induction of ODC mRNA. Tetradecanoylphorbol Acetate 79-82 ornithine decarboxylase, structural 1 Mus musculus 96-99 2832424-12 1988 Stimulation with 8-bromo-cAMP in addition to LPS has been shown to enhance the induction of ODC over that induced by LPS or TPA alone. Tetradecanoylphorbol Acetate 124-127 ornithine decarboxylase, structural 1 Mus musculus 92-95 3338115-0 1988 Palmitoylcarnitine reverses 12-O-tetradecanoylphorbol-13-acetate-induced refractory state for the TPA-caused ornithine decarboxylase induction in mouse epidermis. Tetradecanoylphorbol Acetate 28-64 ornithine decarboxylase, structural 1 Mus musculus 109-132 3338115-0 1988 Palmitoylcarnitine reverses 12-O-tetradecanoylphorbol-13-acetate-induced refractory state for the TPA-caused ornithine decarboxylase induction in mouse epidermis. Tetradecanoylphorbol Acetate 98-101 ornithine decarboxylase, structural 1 Mus musculus 109-132 3338115-7 1988 Pretreatment of mice with TPA 12 h or 96 h before the second TPA application resulted in the reduction or the increase in the Vmax values of ODC both for ornithine and pyridoxal-5"-phosphate, respectively. Tetradecanoylphorbol Acetate 26-29 ornithine decarboxylase, structural 1 Mus musculus 141-144 3338115-1 1988 When a single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) was performed 12 h before the second application, ornithine decarboxylase (ODC) induction by the second application of TPA was markedly suppressed (refractory state). Tetradecanoylphorbol Acetate 37-73 ornithine decarboxylase, structural 1 Mus musculus 130-153 3338115-7 1988 Pretreatment of mice with TPA 12 h or 96 h before the second TPA application resulted in the reduction or the increase in the Vmax values of ODC both for ornithine and pyridoxal-5"-phosphate, respectively. Tetradecanoylphorbol Acetate 61-64 ornithine decarboxylase, structural 1 Mus musculus 141-144 3338115-1 1988 When a single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) was performed 12 h before the second application, ornithine decarboxylase (ODC) induction by the second application of TPA was markedly suppressed (refractory state). Tetradecanoylphorbol Acetate 37-73 ornithine decarboxylase, structural 1 Mus musculus 155-158 3338115-12 1988 The TPA-induced refractory state and the enhanced state for ODC induction appear to result from the changes in the protein kinase C activities caused by TPA. Tetradecanoylphorbol Acetate 153-156 ornithine decarboxylase, structural 1 Mus musculus 60-63 3338115-1 1988 When a single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) was performed 12 h before the second application, ornithine decarboxylase (ODC) induction by the second application of TPA was markedly suppressed (refractory state). Tetradecanoylphorbol Acetate 75-78 ornithine decarboxylase, structural 1 Mus musculus 130-153 3338115-13 1988 However, it is not known whether such changes in the protein kinase C activities are the major causes for the TPA-induced refractory and/or enhanced state for ODC induction and whether or not the restorative effect of palmitoylcarnitine is due to its modulating action on protein kinase C activity. Tetradecanoylphorbol Acetate 110-113 ornithine decarboxylase, structural 1 Mus musculus 159-162 3338115-1 1988 When a single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) was performed 12 h before the second application, ornithine decarboxylase (ODC) induction by the second application of TPA was markedly suppressed (refractory state). Tetradecanoylphorbol Acetate 75-78 ornithine decarboxylase, structural 1 Mus musculus 155-158 3338115-1 1988 When a single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) was performed 12 h before the second application, ornithine decarboxylase (ODC) induction by the second application of TPA was markedly suppressed (refractory state). Tetradecanoylphorbol Acetate 199-202 ornithine decarboxylase, structural 1 Mus musculus 130-153 3338115-1 1988 When a single topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) was performed 12 h before the second application, ornithine decarboxylase (ODC) induction by the second application of TPA was markedly suppressed (refractory state). Tetradecanoylphorbol Acetate 199-202 ornithine decarboxylase, structural 1 Mus musculus 155-158 3338115-2 1988 However, at intervals of 96 h between the first and the second application, the ODC activity induced by the second application of TPA was higher (enhanced state) than the activity induced by the single application. Tetradecanoylphorbol Acetate 130-133 ornithine decarboxylase, structural 1 Mus musculus 80-83 3142649-1 1988 Interrelationship between inflammation and ornithine decarboxylase activity induced in vitro by the carcinogenic 12-O-tetradecanoyl-phorbol-13-acetate]. Tetradecanoylphorbol Acetate 113-150 ornithine decarboxylase, structural 1 Mus musculus 43-66 3076326-0 1988 Mechanisms involved in ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate, a potent mouse skin tumor promoter and an activator of protein kinase C. ODC, the first enzyme in mammalian polyamine biosynthesis, is rapidly induced in response to a wide variety of growth stimuli. Tetradecanoylphorbol Acetate 60-96 ornithine decarboxylase, structural 1 Mus musculus 23-46 3076326-3 1988 Our results indicate that TPA-induced ODC activity is regulated at the transcriptional level. Tetradecanoylphorbol Acetate 26-29 ornithine decarboxylase, structural 1 Mus musculus 38-41 3076326-4 1988 An initial signal in ODC induction by TPA is not clear. Tetradecanoylphorbol Acetate 38-41 ornithine decarboxylase, structural 1 Mus musculus 21-24 3076326-5 1988 We have suggested that TPA-increased accumulation of epidermal prostaglandins is required, but not sufficient, for ODC induction by TPA. Tetradecanoylphorbol Acetate 23-26 ornithine decarboxylase, structural 1 Mus musculus 115-118 3076326-8 1988 The involvement of cyclic nucleotides in ODC induction by TPA is controversial. Tetradecanoylphorbol Acetate 58-61 ornithine decarboxylase, structural 1 Mus musculus 41-44 3076326-9 1988 Also, generation of free radicals appears to be involved in ODC induction by TPA. Tetradecanoylphorbol Acetate 77-80 ornithine decarboxylase, structural 1 Mus musculus 60-63 3076326-10 1988 Data summarized in this chapter indicate that activation of PKC may be an initial step in ODC induction by TPA. Tetradecanoylphorbol Acetate 107-110 ornithine decarboxylase, structural 1 Mus musculus 90-93 3123083-2 1988 Formation of papillomas by applications of TPA to 7,12-dimethylbenz[a]anthracene (DMBA)-initiated mouse skin was effectively inhibited by simultaneous topical applications of MGBB, MGBB also dose-dependently inhibited the ability of TPA to induce increases of ODC activity, ODC mRNA level and the accumulation of putrescine and spermidine in mouse skin. Tetradecanoylphorbol Acetate 43-46 ornithine decarboxylase, structural 1 Mus musculus 260-263 3123083-2 1988 Formation of papillomas by applications of TPA to 7,12-dimethylbenz[a]anthracene (DMBA)-initiated mouse skin was effectively inhibited by simultaneous topical applications of MGBB, MGBB also dose-dependently inhibited the ability of TPA to induce increases of ODC activity, ODC mRNA level and the accumulation of putrescine and spermidine in mouse skin. Tetradecanoylphorbol Acetate 43-46 ornithine decarboxylase, structural 1 Mus musculus 274-277 3142649-2 1988 Topical application of 2 micrograms 12-O-tetradecanoyl-phorbol-13-acetate (TPA) regularly induced two early events in mouse skin: inflammatory reaction localized in dermal compartment and stimulation of ornithine decarboxylase activity in epidermal cells, in relation to polyamine synthesis and cell division. Tetradecanoylphorbol Acetate 36-73 ornithine decarboxylase, structural 1 Mus musculus 203-226 3142649-2 1988 Topical application of 2 micrograms 12-O-tetradecanoyl-phorbol-13-acetate (TPA) regularly induced two early events in mouse skin: inflammatory reaction localized in dermal compartment and stimulation of ornithine decarboxylase activity in epidermal cells, in relation to polyamine synthesis and cell division. Tetradecanoylphorbol Acetate 75-78 ornithine decarboxylase, structural 1 Mus musculus 203-226 3142649-5 1988 At this stage, another TPA treatment induced a strong ODC activity concurrent with severe inflammation of the dermis. Tetradecanoylphorbol Acetate 23-26 ornithine decarboxylase, structural 1 Mus musculus 54-57 3142649-6 1988 Inhibition of the synthesis of inflammatory factors may antagonize TPA-induced ODC, but the protective potencies differs according to the evolutive stages of the cell. Tetradecanoylphorbol Acetate 67-70 ornithine decarboxylase, structural 1 Mus musculus 79-82 3142649-7 1988 After the first TPA treatment the anti-inflammatory compounds dexamethasone and indomethacin effectively inhibited ODC activity. Tetradecanoylphorbol Acetate 16-19 ornithine decarboxylase, structural 1 Mus musculus 115-118 3283748-5 1988 In conclusion, the results presented indicate that the inhibition of TPA-induced ODC gene expression may be one of the mechanisms contributing to the antitumor promoting property of the retinoids. Tetradecanoylphorbol Acetate 69-72 ornithine decarboxylase, structural 1 Mus musculus 81-84 3689369-2 1987 Staurosporine at the concentrations which exert protein kinase C inhibition, however, failed to inhibit, but markedly augmented 12-O-tetradecanoylphorbol-13-acetate (TPA)-caused ornithine decarboxylase (ODC) induction in isolated mouse epidermal cells. Tetradecanoylphorbol Acetate 128-164 ornithine decarboxylase, structural 1 Mus musculus 178-201 3677097-0 1987 Inhibition of 12-O-tetradecanoylphorbol-13-acetate induction of ornithine decarboxylase activity, DNA synthesis, and tumor promotion in mouse skin by ascorbic acid and ascorbyl palmitate. Tetradecanoylphorbol Acetate 14-50 ornithine decarboxylase, structural 1 Mus musculus 64-87 3677097-4 1987 The topical application of relatively small doses of ascorbyl palmitate had a marked inhibitory effect on TPA-induced ornithine decarboxylase activity, DNA synthesis, and tumor promotion in mouse epidermis. Tetradecanoylphorbol Acetate 106-109 ornithine decarboxylase, structural 1 Mus musculus 118-141 3677097-6 1987 The topical application of 4 mumol of ascorbyl palmitate inhibited by 60-76% the induction of epidermal ornithine decarboxylase activity and DNA synthesis that occurred after a single topical application of 2 nmol of TPA whereas similar doses of ascorbic acid had no inhibitory effect. Tetradecanoylphorbol Acetate 217-220 ornithine decarboxylase, structural 1 Mus musculus 104-127 2824029-2 1987 inhibits remarkably and in a dose-dependent manner 12-O-tetradecanoylphorbol-13-acetate (TPA)-decreased glutathione (GSH) peroxidase and TPA-induced ornithine decarboxylase (ODC) activities in mouse epidermis in vivo. Tetradecanoylphorbol Acetate 51-87 ornithine decarboxylase, structural 1 Mus musculus 149-172 2824029-2 1987 inhibits remarkably and in a dose-dependent manner 12-O-tetradecanoylphorbol-13-acetate (TPA)-decreased glutathione (GSH) peroxidase and TPA-induced ornithine decarboxylase (ODC) activities in mouse epidermis in vivo. Tetradecanoylphorbol Acetate 51-87 ornithine decarboxylase, structural 1 Mus musculus 174-177 2824029-2 1987 inhibits remarkably and in a dose-dependent manner 12-O-tetradecanoylphorbol-13-acetate (TPA)-decreased glutathione (GSH) peroxidase and TPA-induced ornithine decarboxylase (ODC) activities in mouse epidermis in vivo. Tetradecanoylphorbol Acetate 89-92 ornithine decarboxylase, structural 1 Mus musculus 149-172 2824029-2 1987 inhibits remarkably and in a dose-dependent manner 12-O-tetradecanoylphorbol-13-acetate (TPA)-decreased glutathione (GSH) peroxidase and TPA-induced ornithine decarboxylase (ODC) activities in mouse epidermis in vivo. Tetradecanoylphorbol Acetate 89-92 ornithine decarboxylase, structural 1 Mus musculus 174-177 2824029-2 1987 inhibits remarkably and in a dose-dependent manner 12-O-tetradecanoylphorbol-13-acetate (TPA)-decreased glutathione (GSH) peroxidase and TPA-induced ornithine decarboxylase (ODC) activities in mouse epidermis in vivo. Tetradecanoylphorbol Acetate 137-140 ornithine decarboxylase, structural 1 Mus musculus 149-172 2824029-2 1987 inhibits remarkably and in a dose-dependent manner 12-O-tetradecanoylphorbol-13-acetate (TPA)-decreased glutathione (GSH) peroxidase and TPA-induced ornithine decarboxylase (ODC) activities in mouse epidermis in vivo. Tetradecanoylphorbol Acetate 137-140 ornithine decarboxylase, structural 1 Mus musculus 174-177 2824029-4 1987 DDTC also inhibits the effects of several structurally different tumor promoters and the greater GSH peroxidase and ODC responses produced by repeated TPA treatments. Tetradecanoylphorbol Acetate 151-154 ornithine decarboxylase, structural 1 Mus musculus 116-119 2824029-5 1987 The inhibitory effects of DDTC on TPA-decreased GSH peroxidase and TPA-induced ODC activities are additive with those of Na2SeO3 and D-alpha-tocopherol (vitamin E). Tetradecanoylphorbol Acetate 34-37 ornithine decarboxylase, structural 1 Mus musculus 79-82 2824029-5 1987 The inhibitory effects of DDTC on TPA-decreased GSH peroxidase and TPA-induced ODC activities are additive with those of Na2SeO3 and D-alpha-tocopherol (vitamin E). Tetradecanoylphorbol Acetate 67-70 ornithine decarboxylase, structural 1 Mus musculus 79-82 3125055-0 1987 The induction of ornithine decarboxylase caused by 12-O-tetradecanoylphorbol-13-acetate in isolated epidermal cells is inhibited by lipoxygenase inhibitors but not by cyclooxygenase inhibitors. Tetradecanoylphorbol Acetate 51-87 ornithine decarboxylase, structural 1 Mus musculus 17-40 3125055-1 1987 The effects of lipoxygenase and cyclooxygenase inhibitors on ornithine decarboxylase (ODC) induction by a potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) were examined in vitro in isolated mouse epidermal cells. Tetradecanoylphorbol Acetate 129-165 ornithine decarboxylase, structural 1 Mus musculus 61-84 3125055-1 1987 The effects of lipoxygenase and cyclooxygenase inhibitors on ornithine decarboxylase (ODC) induction by a potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) were examined in vitro in isolated mouse epidermal cells. Tetradecanoylphorbol Acetate 129-165 ornithine decarboxylase, structural 1 Mus musculus 86-89 3125055-1 1987 The effects of lipoxygenase and cyclooxygenase inhibitors on ornithine decarboxylase (ODC) induction by a potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) were examined in vitro in isolated mouse epidermal cells. Tetradecanoylphorbol Acetate 167-170 ornithine decarboxylase, structural 1 Mus musculus 61-84 3125055-4 1987 These results suggest that the lipoxygenase inhibitors inhibit TPA-caused epidermal ODC induction in mouse skin at least in part by acting directly on epidermal cells while cyclooxygenase inhibitor inhibits it indirectly by acting on cells other than epidermal cells, e.g. cells which are involved in the prostaglandin-dependent inflammatory process. Tetradecanoylphorbol Acetate 63-66 ornithine decarboxylase, structural 1 Mus musculus 84-87 3664957-0 1987 Effect of butyric acid on 12-O-tetradecanoylphorbol-13-acetate-(TPA) induced mouse skin ornithine decarboxylase (ODC). Tetradecanoylphorbol Acetate 26-62 ornithine decarboxylase, structural 1 Mus musculus 88-111 3664957-0 1987 Effect of butyric acid on 12-O-tetradecanoylphorbol-13-acetate-(TPA) induced mouse skin ornithine decarboxylase (ODC). Tetradecanoylphorbol Acetate 26-62 ornithine decarboxylase, structural 1 Mus musculus 113-116 3664957-0 1987 Effect of butyric acid on 12-O-tetradecanoylphorbol-13-acetate-(TPA) induced mouse skin ornithine decarboxylase (ODC). Tetradecanoylphorbol Acetate 64-67 ornithine decarboxylase, structural 1 Mus musculus 88-111 3664957-0 1987 Effect of butyric acid on 12-O-tetradecanoylphorbol-13-acetate-(TPA) induced mouse skin ornithine decarboxylase (ODC). Tetradecanoylphorbol Acetate 64-67 ornithine decarboxylase, structural 1 Mus musculus 113-116 3664957-3 1987 It was found that butyric acid inhibited the TPA-induced mouse skin ODC activity. Tetradecanoylphorbol Acetate 45-48 ornithine decarboxylase, structural 1 Mus musculus 68-71 3689369-2 1987 Staurosporine at the concentrations which exert protein kinase C inhibition, however, failed to inhibit, but markedly augmented 12-O-tetradecanoylphorbol-13-acetate (TPA)-caused ornithine decarboxylase (ODC) induction in isolated mouse epidermal cells. Tetradecanoylphorbol Acetate 128-164 ornithine decarboxylase, structural 1 Mus musculus 203-206 3689369-2 1987 Staurosporine at the concentrations which exert protein kinase C inhibition, however, failed to inhibit, but markedly augmented 12-O-tetradecanoylphorbol-13-acetate (TPA)-caused ornithine decarboxylase (ODC) induction in isolated mouse epidermal cells. Tetradecanoylphorbol Acetate 166-169 ornithine decarboxylase, structural 1 Mus musculus 178-201 3689369-2 1987 Staurosporine at the concentrations which exert protein kinase C inhibition, however, failed to inhibit, but markedly augmented 12-O-tetradecanoylphorbol-13-acetate (TPA)-caused ornithine decarboxylase (ODC) induction in isolated mouse epidermal cells. Tetradecanoylphorbol Acetate 166-169 ornithine decarboxylase, structural 1 Mus musculus 203-206 3689369-5 1987 Another protein kinase C inhibitor, H-7, inhibited both staurosporine- and TPA-caused ODC induction. Tetradecanoylphorbol Acetate 75-78 ornithine decarboxylase, structural 1 Mus musculus 86-89 2884032-5 1987 These agents are very potent inhibitors of growth of melanoma S91 cells and inhibit the induction of ornithine decarboxylase activity by phorbol 12-myristate 13-acetate in 3T6 fibroblasts. Tetradecanoylphorbol Acetate 137-168 ornithine decarboxylase, structural 1 Mus musculus 101-124 3621189-4 1987 In 1 alpha (OH)D3-treated mice, induction of epidermal ODC by 12-O-tetradecanoylphorbol-13-acetate was markedly inhibited, the inhibition being maximal 2 to 4 days after 1 alpha (OH)D3 administration. Tetradecanoylphorbol Acetate 62-98 ornithine decarboxylase, structural 1 Mus musculus 55-58 3477548-10 1987 Likewise, ODC levels are decreased in the 21.1 cells after exposure to PMA even though PMA only slightly modulates the growth of these cells. Tetradecanoylphorbol Acetate 71-74 ornithine decarboxylase, structural 1 Mus musculus 10-13 3612691-4 1987 The biological activity of these heteroarotinoids was assayed by either the suppression of the 12-O-tetradecanoylphorbol 13-acetate (TPA) induced synthesis of ornithine decarboxylase (ODC) in mouse skin or the induction of differentiation of human (HL-60) promyelocytic cells. Tetradecanoylphorbol Acetate 95-131 ornithine decarboxylase, structural 1 Mus musculus 159-182 3612691-4 1987 The biological activity of these heteroarotinoids was assayed by either the suppression of the 12-O-tetradecanoylphorbol 13-acetate (TPA) induced synthesis of ornithine decarboxylase (ODC) in mouse skin or the induction of differentiation of human (HL-60) promyelocytic cells. Tetradecanoylphorbol Acetate 95-131 ornithine decarboxylase, structural 1 Mus musculus 184-187 3612691-4 1987 The biological activity of these heteroarotinoids was assayed by either the suppression of the 12-O-tetradecanoylphorbol 13-acetate (TPA) induced synthesis of ornithine decarboxylase (ODC) in mouse skin or the induction of differentiation of human (HL-60) promyelocytic cells. Tetradecanoylphorbol Acetate 133-136 ornithine decarboxylase, structural 1 Mus musculus 159-182 3107806-8 1987 Indomethacin was found to inhibit TPA-induced ornithine decarboxylase activity to the same extent in both mice. Tetradecanoylphorbol Acetate 34-37 ornithine decarboxylase, structural 1 Mus musculus 46-69 3614203-2 1987 Stimulation of quiescent BALB/c 3T3 mouse fibroblasts with purified fibroblast and platelet-derived growth factors and with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate results in a rapid and dramatic increase in ODC mRNA, similar to the increase caused by serum stimulation. Tetradecanoylphorbol Acetate 143-179 ornithine decarboxylase, structural 1 Mus musculus 224-227 3581045-5 1987 The inhibition of TPA action was shown not to be restricted to DNA synthesis in 3T3 cultured cells since the sialoglycopeptide also inhibited TPA-induced ornithine decarboxylase (ODC, L-ornithine carboxylase, EC 4.1.1.17) activation in suspensions of mouse epidermal and 3T3 cells. Tetradecanoylphorbol Acetate 18-21 ornithine decarboxylase, structural 1 Mus musculus 154-177 3579940-1 1987 Ornithine decarboxylase (ODC) was induced in the liver, lung and brain of the mouse injected intraperitoneally with 12-O-tetradecanoylphorbol 13-acetate (TPA), showing maximal enzyme activity four hours after the injection. Tetradecanoylphorbol Acetate 116-152 ornithine decarboxylase, structural 1 Mus musculus 0-23 3581045-5 1987 The inhibition of TPA action was shown not to be restricted to DNA synthesis in 3T3 cultured cells since the sialoglycopeptide also inhibited TPA-induced ornithine decarboxylase (ODC, L-ornithine carboxylase, EC 4.1.1.17) activation in suspensions of mouse epidermal and 3T3 cells. Tetradecanoylphorbol Acetate 142-145 ornithine decarboxylase, structural 1 Mus musculus 154-177 3581045-5 1987 The inhibition of TPA action was shown not to be restricted to DNA synthesis in 3T3 cultured cells since the sialoglycopeptide also inhibited TPA-induced ornithine decarboxylase (ODC, L-ornithine carboxylase, EC 4.1.1.17) activation in suspensions of mouse epidermal and 3T3 cells. Tetradecanoylphorbol Acetate 142-145 ornithine decarboxylase, structural 1 Mus musculus 179-182 3579940-1 1987 Ornithine decarboxylase (ODC) was induced in the liver, lung and brain of the mouse injected intraperitoneally with 12-O-tetradecanoylphorbol 13-acetate (TPA), showing maximal enzyme activity four hours after the injection. Tetradecanoylphorbol Acetate 116-152 ornithine decarboxylase, structural 1 Mus musculus 25-28 3579940-1 1987 Ornithine decarboxylase (ODC) was induced in the liver, lung and brain of the mouse injected intraperitoneally with 12-O-tetradecanoylphorbol 13-acetate (TPA), showing maximal enzyme activity four hours after the injection. Tetradecanoylphorbol Acetate 154-157 ornithine decarboxylase, structural 1 Mus musculus 0-23 3579940-1 1987 Ornithine decarboxylase (ODC) was induced in the liver, lung and brain of the mouse injected intraperitoneally with 12-O-tetradecanoylphorbol 13-acetate (TPA), showing maximal enzyme activity four hours after the injection. Tetradecanoylphorbol Acetate 154-157 ornithine decarboxylase, structural 1 Mus musculus 25-28 3579940-3 1987 The induction of ODC activity by TPA was specifically blocked by methylglyoxal bis(butylamidinohydrazone) (MGBB), a competitive inhibitor of ODC and S-adenosylmethionine decarboxylase, but not by the analog methylglyoxal bis(guanylhydrazone) (MGBG). Tetradecanoylphorbol Acetate 33-36 ornithine decarboxylase, structural 1 Mus musculus 17-20 3579940-3 1987 The induction of ODC activity by TPA was specifically blocked by methylglyoxal bis(butylamidinohydrazone) (MGBB), a competitive inhibitor of ODC and S-adenosylmethionine decarboxylase, but not by the analog methylglyoxal bis(guanylhydrazone) (MGBG). Tetradecanoylphorbol Acetate 33-36 ornithine decarboxylase, structural 1 Mus musculus 141-144 3032995-0 1987 Effects of diverse intracellular thiol delivery agents on glutathione peroxidase activity, the ratio of reduced/oxidized glutathione, and ornithine decarboxylase induction in isolated mouse epidermal cells treated with 12-O-tetradecanoylphorbol-13-acetate. Tetradecanoylphorbol Acetate 219-255 ornithine decarboxylase, structural 1 Mus musculus 138-161 3032995-3 1987 Moreover, diethyldithiocarbamate prevents totally the initial drop in the GSH/GSSG ratio of TPA-treated cells and is the most potent inhibitor of TPA-decreased GSH peroxidase activity in relation with its remarkable 98% inhibition of TPA-induced ODC activity, suggesting that the potential antitumor-promoting activity of this compound in mouse skin may be far superior to that previously demonstrated by GSH in the initiation-promotion protocol. Tetradecanoylphorbol Acetate 92-95 ornithine decarboxylase, structural 1 Mus musculus 246-249 3032995-3 1987 Moreover, diethyldithiocarbamate prevents totally the initial drop in the GSH/GSSG ratio of TPA-treated cells and is the most potent inhibitor of TPA-decreased GSH peroxidase activity in relation with its remarkable 98% inhibition of TPA-induced ODC activity, suggesting that the potential antitumor-promoting activity of this compound in mouse skin may be far superior to that previously demonstrated by GSH in the initiation-promotion protocol. Tetradecanoylphorbol Acetate 146-149 ornithine decarboxylase, structural 1 Mus musculus 246-249 3032995-3 1987 Moreover, diethyldithiocarbamate prevents totally the initial drop in the GSH/GSSG ratio of TPA-treated cells and is the most potent inhibitor of TPA-decreased GSH peroxidase activity in relation with its remarkable 98% inhibition of TPA-induced ODC activity, suggesting that the potential antitumor-promoting activity of this compound in mouse skin may be far superior to that previously demonstrated by GSH in the initiation-promotion protocol. Tetradecanoylphorbol Acetate 146-149 ornithine decarboxylase, structural 1 Mus musculus 246-249 3769135-5 1986 trans-Retinoic acid, a potent inhibitor of tumor promotion, markedly inhibited the epidermal induction of ornithine decarboxylase activity that resulted from the topical administration of sn-1,2-didecanoylglycerol or TPA. Tetradecanoylphorbol Acetate 217-220 ornithine decarboxylase, structural 1 Mus musculus 106-129 3815331-1 1987 Topical treatment of mouse skin with the potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) results in an array of biochemical alterations, one of the earliest being a more than 200-fold transient induction of epidermal ornithine decarboxylase (ODC) activity. Tetradecanoylphorbol Acetate 63-99 ornithine decarboxylase, structural 1 Mus musculus 234-257 3815331-1 1987 Topical treatment of mouse skin with the potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) results in an array of biochemical alterations, one of the earliest being a more than 200-fold transient induction of epidermal ornithine decarboxylase (ODC) activity. Tetradecanoylphorbol Acetate 63-99 ornithine decarboxylase, structural 1 Mus musculus 259-262 3815331-1 1987 Topical treatment of mouse skin with the potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) results in an array of biochemical alterations, one of the earliest being a more than 200-fold transient induction of epidermal ornithine decarboxylase (ODC) activity. Tetradecanoylphorbol Acetate 101-104 ornithine decarboxylase, structural 1 Mus musculus 234-257 3815331-1 1987 Topical treatment of mouse skin with the potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) results in an array of biochemical alterations, one of the earliest being a more than 200-fold transient induction of epidermal ornithine decarboxylase (ODC) activity. Tetradecanoylphorbol Acetate 101-104 ornithine decarboxylase, structural 1 Mus musculus 259-262 3815331-2 1987 There is an excellent correlation between the induction of epidermal ODC activity and changes in the level of immunoreactive ODC protein following a single TPA treatment to skin. Tetradecanoylphorbol Acetate 156-159 ornithine decarboxylase, structural 1 Mus musculus 69-72 3815331-2 1987 There is an excellent correlation between the induction of epidermal ODC activity and changes in the level of immunoreactive ODC protein following a single TPA treatment to skin. Tetradecanoylphorbol Acetate 156-159 ornithine decarboxylase, structural 1 Mus musculus 125-128 3815331-3 1987 Both ODC activity and protein levels peak at 4.5 h after TPA treatment and rapidly fall to basal levels by 24 h. Cycloheximide treatment of mice in which ODC had been previously induced by TPA indicated a similar rapid turnover of both ODC catalytic activity and protein levels. Tetradecanoylphorbol Acetate 57-60 ornithine decarboxylase, structural 1 Mus musculus 5-8 3815331-3 1987 Both ODC activity and protein levels peak at 4.5 h after TPA treatment and rapidly fall to basal levels by 24 h. Cycloheximide treatment of mice in which ODC had been previously induced by TPA indicated a similar rapid turnover of both ODC catalytic activity and protein levels. Tetradecanoylphorbol Acetate 189-192 ornithine decarboxylase, structural 1 Mus musculus 5-8 3815331-3 1987 Both ODC activity and protein levels peak at 4.5 h after TPA treatment and rapidly fall to basal levels by 24 h. Cycloheximide treatment of mice in which ODC had been previously induced by TPA indicated a similar rapid turnover of both ODC catalytic activity and protein levels. Tetradecanoylphorbol Acetate 189-192 ornithine decarboxylase, structural 1 Mus musculus 154-157 3815331-3 1987 Both ODC activity and protein levels peak at 4.5 h after TPA treatment and rapidly fall to basal levels by 24 h. Cycloheximide treatment of mice in which ODC had been previously induced by TPA indicated a similar rapid turnover of both ODC catalytic activity and protein levels. Tetradecanoylphorbol Acetate 189-192 ornithine decarboxylase, structural 1 Mus musculus 154-157 3815331-4 1987 Northern blot analysis of polyadenylated RNA isolated from mouse epidermis after a single TPA treatment revealed the stimulation of one species of ODC mRNA of 2.0 kilobases with a maximum at 3.5 h declining by 16 h. The same-sized species of ODC mRNA was detected 4.5 h after multiple biweekly treatments with TPA as well as in mouse papillomas and carcinomas not treated with TPA for at least 1 week. Tetradecanoylphorbol Acetate 90-93 ornithine decarboxylase, structural 1 Mus musculus 147-150 3815331-4 1987 Northern blot analysis of polyadenylated RNA isolated from mouse epidermis after a single TPA treatment revealed the stimulation of one species of ODC mRNA of 2.0 kilobases with a maximum at 3.5 h declining by 16 h. The same-sized species of ODC mRNA was detected 4.5 h after multiple biweekly treatments with TPA as well as in mouse papillomas and carcinomas not treated with TPA for at least 1 week. Tetradecanoylphorbol Acetate 90-93 ornithine decarboxylase, structural 1 Mus musculus 242-245 3815331-4 1987 Northern blot analysis of polyadenylated RNA isolated from mouse epidermis after a single TPA treatment revealed the stimulation of one species of ODC mRNA of 2.0 kilobases with a maximum at 3.5 h declining by 16 h. The same-sized species of ODC mRNA was detected 4.5 h after multiple biweekly treatments with TPA as well as in mouse papillomas and carcinomas not treated with TPA for at least 1 week. Tetradecanoylphorbol Acetate 310-313 ornithine decarboxylase, structural 1 Mus musculus 147-150 3815331-4 1987 Northern blot analysis of polyadenylated RNA isolated from mouse epidermis after a single TPA treatment revealed the stimulation of one species of ODC mRNA of 2.0 kilobases with a maximum at 3.5 h declining by 16 h. The same-sized species of ODC mRNA was detected 4.5 h after multiple biweekly treatments with TPA as well as in mouse papillomas and carcinomas not treated with TPA for at least 1 week. Tetradecanoylphorbol Acetate 310-313 ornithine decarboxylase, structural 1 Mus musculus 147-150 3815331-6 1987 These observations indicate that the induction of epidermal ODC activity following TPA treatment results in a transient increase in the steady state levels of ODC mRNA and in the rate of synthesis of ODC protein, in contrast to epidermal tumors where the levels of ODC mRNA and protein are constitutively elevated. Tetradecanoylphorbol Acetate 83-86 ornithine decarboxylase, structural 1 Mus musculus 60-63 3815331-6 1987 These observations indicate that the induction of epidermal ODC activity following TPA treatment results in a transient increase in the steady state levels of ODC mRNA and in the rate of synthesis of ODC protein, in contrast to epidermal tumors where the levels of ODC mRNA and protein are constitutively elevated. Tetradecanoylphorbol Acetate 83-86 ornithine decarboxylase, structural 1 Mus musculus 159-162 3815331-6 1987 These observations indicate that the induction of epidermal ODC activity following TPA treatment results in a transient increase in the steady state levels of ODC mRNA and in the rate of synthesis of ODC protein, in contrast to epidermal tumors where the levels of ODC mRNA and protein are constitutively elevated. Tetradecanoylphorbol Acetate 83-86 ornithine decarboxylase, structural 1 Mus musculus 159-162 3815331-6 1987 These observations indicate that the induction of epidermal ODC activity following TPA treatment results in a transient increase in the steady state levels of ODC mRNA and in the rate of synthesis of ODC protein, in contrast to epidermal tumors where the levels of ODC mRNA and protein are constitutively elevated. Tetradecanoylphorbol Acetate 83-86 ornithine decarboxylase, structural 1 Mus musculus 159-162 3098411-2 1987 At 5 h after their application to the skin, the complete tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the stage 2 promoter mezerein were the most potent in inhibiting GSH peroxidase activity and inducing ODC activity. Tetradecanoylphorbol Acetate 72-108 ornithine decarboxylase, structural 1 Mus musculus 221-224 3098411-2 1987 At 5 h after their application to the skin, the complete tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the stage 2 promoter mezerein were the most potent in inhibiting GSH peroxidase activity and inducing ODC activity. Tetradecanoylphorbol Acetate 110-113 ornithine decarboxylase, structural 1 Mus musculus 221-224 3769135-3 1986 The time course for the induction of ornithine decarboxylase activity by TPA and the time course for its induction by sn-1,2-didecanoylglycerol were similar; both compounds produced rapid increases in ornithine decarboxylase activity with peak induction occurring 4-6 h after application of the inducing chemical. Tetradecanoylphorbol Acetate 73-76 ornithine decarboxylase, structural 1 Mus musculus 37-60 3609441-5 1987 Addition of alpha-amanitin abolished the 12 hr peak, but the TPA induced ODC activity was only partly inhibited. Tetradecanoylphorbol Acetate 61-64 ornithine decarboxylase, structural 1 Mus musculus 73-76 3609441-6 1987 ODC induction by TPA was lower in C3H/10T1/2 CL8 cells initiated with 3-methyl-cholanthrene (MCA). Tetradecanoylphorbol Acetate 17-20 ornithine decarboxylase, structural 1 Mus musculus 0-3 3609441-7 1987 ODC increased with TPA up to 10(-7) M and decreased at higher concentrations of TPA. Tetradecanoylphorbol Acetate 19-22 ornithine decarboxylase, structural 1 Mus musculus 0-3 3609441-7 1987 ODC increased with TPA up to 10(-7) M and decreased at higher concentrations of TPA. Tetradecanoylphorbol Acetate 80-83 ornithine decarboxylase, structural 1 Mus musculus 0-3 3779635-2 1986 A time course and the dose-response curves of ODC induction paralleled that of ODC mRNA induction by TPA in MEC. Tetradecanoylphorbol Acetate 101-104 ornithine decarboxylase, structural 1 Mus musculus 46-49 3779635-2 1986 A time course and the dose-response curves of ODC induction paralleled that of ODC mRNA induction by TPA in MEC. Tetradecanoylphorbol Acetate 101-104 ornithine decarboxylase, structural 1 Mus musculus 79-82 3779635-4 1986 The magnitude of ODC induction was proportional to the amount of ODC mRNA increased by TPA. Tetradecanoylphorbol Acetate 87-90 ornithine decarboxylase, structural 1 Mus musculus 17-20 3779635-4 1986 The magnitude of ODC induction was proportional to the amount of ODC mRNA increased by TPA. Tetradecanoylphorbol Acetate 87-90 ornithine decarboxylase, structural 1 Mus musculus 65-68 3779635-5 1986 TPA (2 X 10(-7) M) failed to induce ODC activity in MEC plated in Ca2+-deprived medium; TPA induction of ODC could be resumed upon Ca2+ restoration in the medium. Tetradecanoylphorbol Acetate 88-91 ornithine decarboxylase, structural 1 Mus musculus 105-108 3779635-10 1986 Furthermore, palmitoylcarnitine, an inhibitor of protein kinase C, inhibited epidermal ODC induction and the increased level of ODC mRNA by TPA. Tetradecanoylphorbol Acetate 140-143 ornithine decarboxylase, structural 1 Mus musculus 128-131 3779635-12 1986 Taken together, we conclude that activation of protein kinase C may be an early event in ODC gene transcription and skin tumor promotion by TPA. Tetradecanoylphorbol Acetate 140-143 ornithine decarboxylase, structural 1 Mus musculus 89-92 3770209-1 1986 Two ornithine decarboxylase mRNA species are seen in mouse epidermis in response to the topical application of the phorbol ester tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 145-182 ornithine decarboxylase, structural 1 Mus musculus 4-27 3770209-1 1986 Two ornithine decarboxylase mRNA species are seen in mouse epidermis in response to the topical application of the phorbol ester tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 184-187 ornithine decarboxylase, structural 1 Mus musculus 4-27 3094975-0 1986 Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects. Tetradecanoylphorbol Acetate 14-50 ornithine decarboxylase, structural 1 Mus musculus 70-93 3094975-4 1986 Induction of epidermal ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate (TPA; 10 nmol/mouse) was potently inhibited by these agents in a dose-dependent manner (1-30 mumol/mouse). Tetradecanoylphorbol Acetate 50-86 ornithine decarboxylase, structural 1 Mus musculus 23-46 3094975-4 1986 Induction of epidermal ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate (TPA; 10 nmol/mouse) was potently inhibited by these agents in a dose-dependent manner (1-30 mumol/mouse). Tetradecanoylphorbol Acetate 88-91 ornithine decarboxylase, structural 1 Mus musculus 23-46 3094508-1 1986 12-O-tetradecanoylphorbol-13-acetate (TPA) induced in Balb/c 3T3 cells an earliest prostaglandin biosynthesis and an ornithine decarboxylase activation, this time-relation being more evident if serum was added to incubation medium in low concentration (0.2%). Tetradecanoylphorbol Acetate 0-36 ornithine decarboxylase, structural 1 Mus musculus 117-140 3768852-1 1986 Ornithine decarboxylase (ODC EC 4.1.1.17) induction in mouse epidermis after single or multiple topical applications of chrysarobin differed from that following topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 222-225 ornithine decarboxylase, structural 1 Mus musculus 0-23 3094508-1 1986 12-O-tetradecanoylphorbol-13-acetate (TPA) induced in Balb/c 3T3 cells an earliest prostaglandin biosynthesis and an ornithine decarboxylase activation, this time-relation being more evident if serum was added to incubation medium in low concentration (0.2%). Tetradecanoylphorbol Acetate 38-41 ornithine decarboxylase, structural 1 Mus musculus 117-140 3015445-1 1986 In order to investigate the correlation between stimulation of superoxide generation and induction of ornithine decarboxylase (ODC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) we have used the macrophage cell line J774.16 and a clone derived from this line that, by contrast with the parental line, is unable to generate superoxides in response to TPA. Tetradecanoylphorbol Acetate 135-171 ornithine decarboxylase, structural 1 Mus musculus 102-125 3733713-6 1986 Similarly, pretreatment with PMA abolished the ability of additional PMA to increase ornithine decarboxylase mRNA levels but did not prevent the increases in these mRNA levels caused by FGF or serum. Tetradecanoylphorbol Acetate 29-32 ornithine decarboxylase, structural 1 Mus musculus 85-108 3015445-1 1986 In order to investigate the correlation between stimulation of superoxide generation and induction of ornithine decarboxylase (ODC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) we have used the macrophage cell line J774.16 and a clone derived from this line that, by contrast with the parental line, is unable to generate superoxides in response to TPA. Tetradecanoylphorbol Acetate 135-171 ornithine decarboxylase, structural 1 Mus musculus 127-130 3085964-9 1986 The retinoid and DFMO preclude TPA-increased ornithine decarboxylase (ODC) activity and the accumulation of putrescine by differential effects on ODC, an enzyme associated with skin tumor promotion by TPA. Tetradecanoylphorbol Acetate 31-34 ornithine decarboxylase, structural 1 Mus musculus 45-68 3015445-1 1986 In order to investigate the correlation between stimulation of superoxide generation and induction of ornithine decarboxylase (ODC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) we have used the macrophage cell line J774.16 and a clone derived from this line that, by contrast with the parental line, is unable to generate superoxides in response to TPA. Tetradecanoylphorbol Acetate 173-176 ornithine decarboxylase, structural 1 Mus musculus 102-125 3015445-1 1986 In order to investigate the correlation between stimulation of superoxide generation and induction of ornithine decarboxylase (ODC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) we have used the macrophage cell line J774.16 and a clone derived from this line that, by contrast with the parental line, is unable to generate superoxides in response to TPA. Tetradecanoylphorbol Acetate 173-176 ornithine decarboxylase, structural 1 Mus musculus 127-130 3015445-1 1986 In order to investigate the correlation between stimulation of superoxide generation and induction of ornithine decarboxylase (ODC) by 12-O-tetradecanoylphorbol-13-acetate (TPA) we have used the macrophage cell line J774.16 and a clone derived from this line that, by contrast with the parental line, is unable to generate superoxides in response to TPA. Tetradecanoylphorbol Acetate 350-353 ornithine decarboxylase, structural 1 Mus musculus 127-130 3015445-2 1986 No difference was observed between the normal and the defective cells, with respect to ODC induction by TPA over a wide range of TPA concentrations (0.2-5.0 micrograms/ml). Tetradecanoylphorbol Acetate 104-107 ornithine decarboxylase, structural 1 Mus musculus 87-90 3099748-1 1986 Evidence was sought that the tumour promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse epidermal ornithine decarboxylase (ODC, EC 4.1.1.17) activity involves both increased ODC mRNA and ODC protein. Tetradecanoylphorbol Acetate 83-86 ornithine decarboxylase, structural 1 Mus musculus 112-135 3099748-1 1986 Evidence was sought that the tumour promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse epidermal ornithine decarboxylase (ODC, EC 4.1.1.17) activity involves both increased ODC mRNA and ODC protein. Tetradecanoylphorbol Acetate 83-86 ornithine decarboxylase, structural 1 Mus musculus 137-140 3099748-1 1986 Evidence was sought that the tumour promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse epidermal ornithine decarboxylase (ODC, EC 4.1.1.17) activity involves both increased ODC mRNA and ODC protein. Tetradecanoylphorbol Acetate 83-86 ornithine decarboxylase, structural 1 Mus musculus 188-191 3099748-1 1986 Evidence was sought that the tumour promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse epidermal ornithine decarboxylase (ODC, EC 4.1.1.17) activity involves both increased ODC mRNA and ODC protein. Tetradecanoylphorbol Acetate 83-86 ornithine decarboxylase, structural 1 Mus musculus 188-191 3099748-2 1986 Application of 10 nmol of TPA to mouse skin led to a dramatic increase in soluble epidermal ODC activity which paralleled an increase in amount of enzymically active ODC protein as determined by gel electrophoresis of immunoprecipitated difluoromethyl[3H]ornithine-bound ODC. Tetradecanoylphorbol Acetate 26-29 ornithine decarboxylase, structural 1 Mus musculus 92-95 3099748-2 1986 Application of 10 nmol of TPA to mouse skin led to a dramatic increase in soluble epidermal ODC activity which paralleled an increase in amount of enzymically active ODC protein as determined by gel electrophoresis of immunoprecipitated difluoromethyl[3H]ornithine-bound ODC. Tetradecanoylphorbol Acetate 26-29 ornithine decarboxylase, structural 1 Mus musculus 166-169 3099748-2 1986 Application of 10 nmol of TPA to mouse skin led to a dramatic increase in soluble epidermal ODC activity which paralleled an increase in amount of enzymically active ODC protein as determined by gel electrophoresis of immunoprecipitated difluoromethyl[3H]ornithine-bound ODC. Tetradecanoylphorbol Acetate 26-29 ornithine decarboxylase, structural 1 Mus musculus 166-169 3099748-3 1986 Application of TPA to mouse skin also resulted in an increase in ODC mRNA measured by dot-blot analysis using a radiolabelled cDNA probe. Tetradecanoylphorbol Acetate 15-18 ornithine decarboxylase, structural 1 Mus musculus 65-68 3099748-4 1986 ODC mRNA induction preceded the increase in ODC activity by TPA. Tetradecanoylphorbol Acetate 60-63 ornithine decarboxylase, structural 1 Mus musculus 44-47 3099748-5 1986 TPA-increased ODC mRNA displayed a single major band of 2.1 kilobases in size identified by the Northern blotting procedure. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 14-17 3087287-6 1986 Epidermal ODC activity increased by TPA appears to be the result of an increase in both the amount of ODC protein and the level of hybridizable ODC messenger. Tetradecanoylphorbol Acetate 36-39 ornithine decarboxylase, structural 1 Mus musculus 102-105 3087287-6 1986 Epidermal ODC activity increased by TPA appears to be the result of an increase in both the amount of ODC protein and the level of hybridizable ODC messenger. Tetradecanoylphorbol Acetate 36-39 ornithine decarboxylase, structural 1 Mus musculus 102-105 2423265-0 1986 Heterogeneity of ornithine decarboxylase expression in 12-O-tetradecanoylphorbol-13-acetate-treated mouse skin and in epidermal tumors. Tetradecanoylphorbol Acetate 55-91 ornithine decarboxylase, structural 1 Mus musculus 17-40 2423265-1 1986 One of the earliest events after treatment of mouse skin with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is the induction of ornithine decarboxylase (ODC). Tetradecanoylphorbol Acetate 81-117 ornithine decarboxylase, structural 1 Mus musculus 144-167 2423265-1 1986 One of the earliest events after treatment of mouse skin with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is the induction of ornithine decarboxylase (ODC). Tetradecanoylphorbol Acetate 81-117 ornithine decarboxylase, structural 1 Mus musculus 169-172 2423265-1 1986 One of the earliest events after treatment of mouse skin with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is the induction of ornithine decarboxylase (ODC). Tetradecanoylphorbol Acetate 119-122 ornithine decarboxylase, structural 1 Mus musculus 144-167 2423265-1 1986 One of the earliest events after treatment of mouse skin with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) is the induction of ornithine decarboxylase (ODC). Tetradecanoylphorbol Acetate 119-122 ornithine decarboxylase, structural 1 Mus musculus 169-172 2423265-2 1986 Using an immunoperoxidase technique with a rabbit antiserum specific for ODC, the localization of cells containing high levels of ODC following TPA treatment was determined. Tetradecanoylphorbol Acetate 144-147 ornithine decarboxylase, structural 1 Mus musculus 73-76 2423265-2 1986 Using an immunoperoxidase technique with a rabbit antiserum specific for ODC, the localization of cells containing high levels of ODC following TPA treatment was determined. Tetradecanoylphorbol Acetate 144-147 ornithine decarboxylase, structural 1 Mus musculus 130-133 2423265-3 1986 CD-1 female mice treated with multiple topical applications of TPA and killed 4.5 h after the last TPA treatment exhibited a heterogeneous localization of ODC in this hyperplastic epidermis. Tetradecanoylphorbol Acetate 63-66 ornithine decarboxylase, structural 1 Mus musculus 155-158 2423265-5 1986 This specific ODC staining in cells surrounding hair follicles was inhibited by pretreatment of mice with either retinoic acid or cycloheximide 1 h before TPA treatment. Tetradecanoylphorbol Acetate 155-158 ornithine decarboxylase, structural 1 Mus musculus 14-17 2423265-6 1986 The induction of ODC-specific staining after TPA treatment in hyperplastic mouse skin was transient, since no staining was observed 16 or 24 h after TPA treatment. Tetradecanoylphorbol Acetate 45-48 ornithine decarboxylase, structural 1 Mus musculus 17-20 2423265-6 1986 The induction of ODC-specific staining after TPA treatment in hyperplastic mouse skin was transient, since no staining was observed 16 or 24 h after TPA treatment. Tetradecanoylphorbol Acetate 149-152 ornithine decarboxylase, structural 1 Mus musculus 17-20 2423265-7 1986 In contrast, benign papillomas produced by two-stage tumorigenesis contained some cells demonstrating high levels of ODC a week after the last TPA application. Tetradecanoylphorbol Acetate 143-146 ornithine decarboxylase, structural 1 Mus musculus 117-120 2871947-12 1986 TPA treatment also increased ornithine decarboxylase activity in all lines, even at the higher Ca2+ concentration, although normal keratinocytes respond only when grown in medium with low Ca2+. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 29-52 3708757-7 1986 Anti-promotion properties were assessed by measuring the effects of apigenin, robinetin and indole-3-carbinol on induction of ornithine decarboxylase activity (ODC) in mouse epidermis by 17 nmol 12-O-tetradecanoyl phorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 195-232 ornithine decarboxylase, structural 1 Mus musculus 126-149 3708757-7 1986 Anti-promotion properties were assessed by measuring the effects of apigenin, robinetin and indole-3-carbinol on induction of ornithine decarboxylase activity (ODC) in mouse epidermis by 17 nmol 12-O-tetradecanoyl phorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 195-232 ornithine decarboxylase, structural 1 Mus musculus 160-163 3708757-7 1986 Anti-promotion properties were assessed by measuring the effects of apigenin, robinetin and indole-3-carbinol on induction of ornithine decarboxylase activity (ODC) in mouse epidermis by 17 nmol 12-O-tetradecanoyl phorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 234-237 ornithine decarboxylase, structural 1 Mus musculus 160-163 3708757-11 1986 Inhibition by 30-90% of TPA-induced ODC was observed at 6 h after TPA in mice pretreated with 12.5-100 mumol apigenin. Tetradecanoylphorbol Acetate 24-27 ornithine decarboxylase, structural 1 Mus musculus 36-39 3708757-11 1986 Inhibition by 30-90% of TPA-induced ODC was observed at 6 h after TPA in mice pretreated with 12.5-100 mumol apigenin. Tetradecanoylphorbol Acetate 66-69 ornithine decarboxylase, structural 1 Mus musculus 36-39 3708757-12 1986 Pretreatment with 37.5 or 50 mumol indole-3-carbinol or 0.5, 12.5 or 25 mumol robinetin resulted in elevated induction of epidermal ODC by TPA at 6 h after TPA. Tetradecanoylphorbol Acetate 139-142 ornithine decarboxylase, structural 1 Mus musculus 132-135 3708757-12 1986 Pretreatment with 37.5 or 50 mumol indole-3-carbinol or 0.5, 12.5 or 25 mumol robinetin resulted in elevated induction of epidermal ODC by TPA at 6 h after TPA. Tetradecanoylphorbol Acetate 156-159 ornithine decarboxylase, structural 1 Mus musculus 132-135 3708757-13 1986 However, treatment with 50 or 100 mumol robinetin diminished ODC induction at 6 h after TPA. Tetradecanoylphorbol Acetate 88-91 ornithine decarboxylase, structural 1 Mus musculus 61-64 3099748-0 1986 Increased mouse epidermal ornithine decarboxylase activity by the tumour promoter 12-O-tetradecanoylphorbol 13-acetate involves increased amounts of both enzyme protein and messenger RNA. Tetradecanoylphorbol Acetate 82-118 ornithine decarboxylase, structural 1 Mus musculus 26-49 3099748-1 1986 Evidence was sought that the tumour promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse epidermal ornithine decarboxylase (ODC, EC 4.1.1.17) activity involves both increased ODC mRNA and ODC protein. Tetradecanoylphorbol Acetate 45-81 ornithine decarboxylase, structural 1 Mus musculus 112-135 3099748-1 1986 Evidence was sought that the tumour promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse epidermal ornithine decarboxylase (ODC, EC 4.1.1.17) activity involves both increased ODC mRNA and ODC protein. Tetradecanoylphorbol Acetate 45-81 ornithine decarboxylase, structural 1 Mus musculus 137-140 3099748-1 1986 Evidence was sought that the tumour promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse epidermal ornithine decarboxylase (ODC, EC 4.1.1.17) activity involves both increased ODC mRNA and ODC protein. Tetradecanoylphorbol Acetate 45-81 ornithine decarboxylase, structural 1 Mus musculus 188-191 3099748-1 1986 Evidence was sought that the tumour promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse epidermal ornithine decarboxylase (ODC, EC 4.1.1.17) activity involves both increased ODC mRNA and ODC protein. Tetradecanoylphorbol Acetate 45-81 ornithine decarboxylase, structural 1 Mus musculus 188-191 3087287-0 1986 Induction of mouse epidermal ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate: dependence on calcium availability. Tetradecanoylphorbol Acetate 75-111 ornithine decarboxylase, structural 1 Mus musculus 29-52 3087287-1 1986 The role of calcium in epidermal ornithine decarboxylase (ODC) induction by 12-O-tetradecanoylphorbol-13-acetate (TPA) was determined in adult mouse skin pieces incubated in serum-free minimal essential medium (MEM). Tetradecanoylphorbol Acetate 76-112 ornithine decarboxylase, structural 1 Mus musculus 33-56 3087287-1 1986 The role of calcium in epidermal ornithine decarboxylase (ODC) induction by 12-O-tetradecanoylphorbol-13-acetate (TPA) was determined in adult mouse skin pieces incubated in serum-free minimal essential medium (MEM). Tetradecanoylphorbol Acetate 76-112 ornithine decarboxylase, structural 1 Mus musculus 58-61 3087287-1 1986 The role of calcium in epidermal ornithine decarboxylase (ODC) induction by 12-O-tetradecanoylphorbol-13-acetate (TPA) was determined in adult mouse skin pieces incubated in serum-free minimal essential medium (MEM). Tetradecanoylphorbol Acetate 114-117 ornithine decarboxylase, structural 1 Mus musculus 33-56 3087287-1 1986 The role of calcium in epidermal ornithine decarboxylase (ODC) induction by 12-O-tetradecanoylphorbol-13-acetate (TPA) was determined in adult mouse skin pieces incubated in serum-free minimal essential medium (MEM). Tetradecanoylphorbol Acetate 114-117 ornithine decarboxylase, structural 1 Mus musculus 58-61 3087287-2 1986 Addition of TPA to skin pieces incubated in serum-free MEM, which contains 1.82 mM Ca2+ and 0.83 mM Mg2+, resulted in about a 200-fold increase in epidermal ODC activity at about 8 h after TPA treatment. Tetradecanoylphorbol Acetate 12-15 ornithine decarboxylase, structural 1 Mus musculus 157-160 3087287-4 1986 Similarly, chelation of extracellular calcium by ethyleneglycol bis(beta-aminoethyl ether) N,N"-tetraacetic acid (EGTA) prevented ODC induction by TPA, which could be resumed upon calcium restoration in the medium. Tetradecanoylphorbol Acetate 147-150 ornithine decarboxylase, structural 1 Mus musculus 130-133 3087287-6 1986 Epidermal ODC activity increased by TPA appears to be the result of an increase in both the amount of ODC protein and the level of hybridizable ODC messenger. Tetradecanoylphorbol Acetate 36-39 ornithine decarboxylase, structural 1 Mus musculus 10-13 3458547-2 1986 Under identical conditions 7,8-BF also partially suppressed ornithine decarboxylase (ODC) activity in both unstimulated and TPA stimulated cultures. Tetradecanoylphorbol Acetate 124-127 ornithine decarboxylase, structural 1 Mus musculus 60-83 3458547-2 1986 Under identical conditions 7,8-BF also partially suppressed ornithine decarboxylase (ODC) activity in both unstimulated and TPA stimulated cultures. Tetradecanoylphorbol Acetate 124-127 ornithine decarboxylase, structural 1 Mus musculus 85-88 3458547-3 1986 The finding that 7,8-BF inhibition of TPA-induced ODC can not be overcome by addition of exogenous PGE2 suggests that ODC induction by TPA involves a prostaglandin-independent component. Tetradecanoylphorbol Acetate 38-41 ornithine decarboxylase, structural 1 Mus musculus 50-53 3458547-3 1986 The finding that 7,8-BF inhibition of TPA-induced ODC can not be overcome by addition of exogenous PGE2 suggests that ODC induction by TPA involves a prostaglandin-independent component. Tetradecanoylphorbol Acetate 135-138 ornithine decarboxylase, structural 1 Mus musculus 118-121 3085964-9 1986 The retinoid and DFMO preclude TPA-increased ornithine decarboxylase (ODC) activity and the accumulation of putrescine by differential effects on ODC, an enzyme associated with skin tumor promotion by TPA. Tetradecanoylphorbol Acetate 31-34 ornithine decarboxylase, structural 1 Mus musculus 70-73 3085964-9 1986 The retinoid and DFMO preclude TPA-increased ornithine decarboxylase (ODC) activity and the accumulation of putrescine by differential effects on ODC, an enzyme associated with skin tumor promotion by TPA. Tetradecanoylphorbol Acetate 201-204 ornithine decarboxylase, structural 1 Mus musculus 146-149 3008983-6 1986 Because retinoids do not directly affect TPA binding to PK-C, the data suggest that (i) the presence of retinoic acid results in the exposure of heretofore cryptic TPA-binding sites in the membrane, where this binding is most likely related to the alteration of membrane structure and (ii) de novo ODC induction is not required for retinoid-dependent inhibition of PK-C, although the TPA induction of PK-C appears to be necessary with regard to ODC induction. Tetradecanoylphorbol Acetate 164-167 ornithine decarboxylase, structural 1 Mus musculus 298-301 3081453-2 1986 When direct induction of ODC by TPA was blocked by also applying indomethacin, maximum ODC activity occurred only when PGE was applied simultaneously with TPA 4 1/2 hr before killing of the mice. Tetradecanoylphorbol Acetate 32-35 ornithine decarboxylase, structural 1 Mus musculus 25-28 3081453-2 1986 When direct induction of ODC by TPA was blocked by also applying indomethacin, maximum ODC activity occurred only when PGE was applied simultaneously with TPA 4 1/2 hr before killing of the mice. Tetradecanoylphorbol Acetate 32-35 ornithine decarboxylase, structural 1 Mus musculus 87-90 3081453-2 1986 When direct induction of ODC by TPA was blocked by also applying indomethacin, maximum ODC activity occurred only when PGE was applied simultaneously with TPA 4 1/2 hr before killing of the mice. Tetradecanoylphorbol Acetate 155-158 ornithine decarboxylase, structural 1 Mus musculus 25-28 3081453-2 1986 When direct induction of ODC by TPA was blocked by also applying indomethacin, maximum ODC activity occurred only when PGE was applied simultaneously with TPA 4 1/2 hr before killing of the mice. Tetradecanoylphorbol Acetate 155-158 ornithine decarboxylase, structural 1 Mus musculus 87-90 3081453-3 1986 If either TPA or PGE was applied at other times, ODC activity decreased substantially. Tetradecanoylphorbol Acetate 10-13 ornithine decarboxylase, structural 1 Mus musculus 49-52 3081453-4 1986 Induction of ODC by mezerein was blocked by indomethacin but restored by PGE, as was observed with TPA, but induction by ethyl phenylpropiolate was not affected by indomethacin or PGE. Tetradecanoylphorbol Acetate 99-102 ornithine decarboxylase, structural 1 Mus musculus 13-16 3081453-7 1986 Inhibition by topical retinoic acid of ODC induction by TPA was partially overcome in a dose-response fashion by PGE. Tetradecanoylphorbol Acetate 56-59 ornithine decarboxylase, structural 1 Mus musculus 39-42 3081251-1 1986 Palmitoylcarnitine, which has been reported to be an inhibitor of calcium-activated, phospholipid-dependent protein kinase (protein kinase C), inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced epidermal ornithine decarboxylase in mouse skin in a dose-dependent manner. Tetradecanoylphorbol Acetate 191-194 ornithine decarboxylase, structural 1 Mus musculus 214-237 3008983-6 1986 Because retinoids do not directly affect TPA binding to PK-C, the data suggest that (i) the presence of retinoic acid results in the exposure of heretofore cryptic TPA-binding sites in the membrane, where this binding is most likely related to the alteration of membrane structure and (ii) de novo ODC induction is not required for retinoid-dependent inhibition of PK-C, although the TPA induction of PK-C appears to be necessary with regard to ODC induction. Tetradecanoylphorbol Acetate 164-167 ornithine decarboxylase, structural 1 Mus musculus 445-448 3008983-6 1986 Because retinoids do not directly affect TPA binding to PK-C, the data suggest that (i) the presence of retinoic acid results in the exposure of heretofore cryptic TPA-binding sites in the membrane, where this binding is most likely related to the alteration of membrane structure and (ii) de novo ODC induction is not required for retinoid-dependent inhibition of PK-C, although the TPA induction of PK-C appears to be necessary with regard to ODC induction. Tetradecanoylphorbol Acetate 164-167 ornithine decarboxylase, structural 1 Mus musculus 298-301 3008983-6 1986 Because retinoids do not directly affect TPA binding to PK-C, the data suggest that (i) the presence of retinoic acid results in the exposure of heretofore cryptic TPA-binding sites in the membrane, where this binding is most likely related to the alteration of membrane structure and (ii) de novo ODC induction is not required for retinoid-dependent inhibition of PK-C, although the TPA induction of PK-C appears to be necessary with regard to ODC induction. Tetradecanoylphorbol Acetate 164-167 ornithine decarboxylase, structural 1 Mus musculus 445-448 3940182-0 1986 Tumor promoter-induced refractory state against ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate in mouse epidermis. Tetradecanoylphorbol Acetate 85-121 ornithine decarboxylase, structural 1 Mus musculus 48-71 3081271-0 1986 Effects of lipoxygenase and cyclooxygenase inhibitors on the induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate and isoproterenol in mouse tissues in vivo. Tetradecanoylphorbol Acetate 101-137 ornithine decarboxylase, structural 1 Mus musculus 74-97 3081271-2 1986 administration of 12-O-tetradecanoylphorbol-13-acetate (TPA) (400 micrograms/kg) caused a remarkable increase in ornithine decarboxylase (ODC) activity in CD-1 mouse liver (8.3-fold), spleen (17.8-fold), kidney (4-fold), lung (7.7-fold) and brain (2.7-fold). Tetradecanoylphorbol Acetate 18-54 ornithine decarboxylase, structural 1 Mus musculus 113-136 3081271-2 1986 administration of 12-O-tetradecanoylphorbol-13-acetate (TPA) (400 micrograms/kg) caused a remarkable increase in ornithine decarboxylase (ODC) activity in CD-1 mouse liver (8.3-fold), spleen (17.8-fold), kidney (4-fold), lung (7.7-fold) and brain (2.7-fold). Tetradecanoylphorbol Acetate 18-54 ornithine decarboxylase, structural 1 Mus musculus 138-141 3081271-2 1986 administration of 12-O-tetradecanoylphorbol-13-acetate (TPA) (400 micrograms/kg) caused a remarkable increase in ornithine decarboxylase (ODC) activity in CD-1 mouse liver (8.3-fold), spleen (17.8-fold), kidney (4-fold), lung (7.7-fold) and brain (2.7-fold). Tetradecanoylphorbol Acetate 56-59 ornithine decarboxylase, structural 1 Mus musculus 113-136 3081271-2 1986 administration of 12-O-tetradecanoylphorbol-13-acetate (TPA) (400 micrograms/kg) caused a remarkable increase in ornithine decarboxylase (ODC) activity in CD-1 mouse liver (8.3-fold), spleen (17.8-fold), kidney (4-fold), lung (7.7-fold) and brain (2.7-fold). Tetradecanoylphorbol Acetate 56-59 ornithine decarboxylase, structural 1 Mus musculus 138-141 3081271-3 1986 TPA induced an increase in ODC activity in liver, spleen and kidney in a dose-dependent manner (100-800 micrograms/kg). Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 27-30 3081271-5 1986 BW755C, an inhibitor of cyclooxygenase and lipoxygenase, prevented the TPA-induced increase in ODC activity in liver, spleen and kidney in a dose-dependent manner. Tetradecanoylphorbol Acetate 71-74 ornithine decarboxylase, structural 1 Mus musculus 95-98 3081271-6 1986 AA861-a selective lipoxygenase inhibitor, also showed the inhibition of TPA-induced increase in ODC activity in these tissues. Tetradecanoylphorbol Acetate 72-75 ornithine decarboxylase, structural 1 Mus musculus 96-99 3081271-8 1986 On the other hand, indomethacin, a selective cyclooxygenase inhibitor, enhanced the TPA-induced increase in ODC activity in these tissues dose-dependently. Tetradecanoylphorbol Acetate 84-87 ornithine decarboxylase, structural 1 Mus musculus 108-111 3081271-12 1986 These results indicate that product(s) of lipoxygenase pathway play an important role in ODC induction caused by TPA in liver, spleen and kidney, while the lipoxygenase pathway does not play an essential role in the isoproterenol-induced increase in ODC activity. Tetradecanoylphorbol Acetate 113-116 ornithine decarboxylase, structural 1 Mus musculus 89-92 3940182-1 1986 More than one application of the potent tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA), to mouse skin at intervals of more than 48 h led to a larger induction of ornithine decarboxylase (EC 4.1.1.17; ODC) than did a single application. Tetradecanoylphorbol Acetate 63-99 ornithine decarboxylase, structural 1 Mus musculus 181-204 3940182-1 1986 More than one application of the potent tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA), to mouse skin at intervals of more than 48 h led to a larger induction of ornithine decarboxylase (EC 4.1.1.17; ODC) than did a single application. Tetradecanoylphorbol Acetate 63-99 ornithine decarboxylase, structural 1 Mus musculus 219-222 3940182-1 1986 More than one application of the potent tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA), to mouse skin at intervals of more than 48 h led to a larger induction of ornithine decarboxylase (EC 4.1.1.17; ODC) than did a single application. Tetradecanoylphorbol Acetate 101-104 ornithine decarboxylase, structural 1 Mus musculus 181-204 3940182-1 1986 More than one application of the potent tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate (TPA), to mouse skin at intervals of more than 48 h led to a larger induction of ornithine decarboxylase (EC 4.1.1.17; ODC) than did a single application. Tetradecanoylphorbol Acetate 101-104 ornithine decarboxylase, structural 1 Mus musculus 219-222 3940182-6 1986 On the other hand, pretreatment with TPA caused a refractory effect on ODC induction by mezerein but potentiated ODC induction by ethylphenylpropiolate. Tetradecanoylphorbol Acetate 37-40 ornithine decarboxylase, structural 1 Mus musculus 71-74 3940182-6 1986 On the other hand, pretreatment with TPA caused a refractory effect on ODC induction by mezerein but potentiated ODC induction by ethylphenylpropiolate. Tetradecanoylphorbol Acetate 37-40 ornithine decarboxylase, structural 1 Mus musculus 113-116 3940182-7 1986 The epidermal cells escaped from the refractory state by repeated application of TPA at intervals of 24 h as well as at intervals of twice a week; that is, there was a full induction of ODC activity following a second application within 24 h of a prior application. Tetradecanoylphorbol Acetate 81-84 ornithine decarboxylase, structural 1 Mus musculus 186-189 3940182-9 1986 Mixing of a soluble extract from mouse epidermis in the refractory state with that from TPA-stimulated epidermis gave essentially additive ODC activity. Tetradecanoylphorbol Acetate 88-91 ornithine decarboxylase, structural 1 Mus musculus 139-142 3940182-11 1986 These results suggest that the refractory effect on ODC induction by TPA does not result from feedback regulation of ODC. Tetradecanoylphorbol Acetate 69-72 ornithine decarboxylase, structural 1 Mus musculus 52-55 4075283-3 1985 The ability of ADR to deplete the intracellular level of GSH correlated with its ability to increase basal and TPA-induced ornithine decarboxylase (ODC, L-ornithine carboxylase, EC 4.1.1.17) activities. Tetradecanoylphorbol Acetate 111-114 ornithine decarboxylase, structural 1 Mus musculus 123-146 3083437-0 1986 Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and tumor promotion by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) in mouse skin. Tetradecanoylphorbol Acetate 14-50 ornithine decarboxylase, structural 1 Mus musculus 69-92 3083437-1 1986 N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) inhibited epidermal ornithine decarboxylase (ODC) induction caused either by 12-O-tetradecanoylphorbol-13-acetate (TPA) or teleocidin in CD-1 mice. Tetradecanoylphorbol Acetate 134-170 ornithine decarboxylase, structural 1 Mus musculus 77-100 3083437-1 1986 N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) inhibited epidermal ornithine decarboxylase (ODC) induction caused either by 12-O-tetradecanoylphorbol-13-acetate (TPA) or teleocidin in CD-1 mice. Tetradecanoylphorbol Acetate 134-170 ornithine decarboxylase, structural 1 Mus musculus 102-105 3083437-1 1986 N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) inhibited epidermal ornithine decarboxylase (ODC) induction caused either by 12-O-tetradecanoylphorbol-13-acetate (TPA) or teleocidin in CD-1 mice. Tetradecanoylphorbol Acetate 172-175 ornithine decarboxylase, structural 1 Mus musculus 102-105 3083437-2 1986 Inhibitory effect of W-7 on TPA-caused ODC induction was also observed in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated skin and even after repetitive TPA treatment. Tetradecanoylphorbol Acetate 28-31 ornithine decarboxylase, structural 1 Mus musculus 39-42 3083437-2 1986 Inhibitory effect of W-7 on TPA-caused ODC induction was also observed in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated skin and even after repetitive TPA treatment. Tetradecanoylphorbol Acetate 153-156 ornithine decarboxylase, structural 1 Mus musculus 39-42 4053280-4 1985 We have developed an assay system which effectively measured tumor promoter (TPA)-induced ornithine decarboxylase activity on 3-4 mm skin samples from mice and humans. Tetradecanoylphorbol Acetate 77-80 ornithine decarboxylase, structural 1 Mus musculus 90-113 4066760-0 1985 Phorbol esters and gene expression: the role of rapid changes in K+ transport in the induction of ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate in BALB/c 3T3 cells and a mutant cell line defective in Na+K+Cl- cotransport. Tetradecanoylphorbol Acetate 125-161 ornithine decarboxylase, structural 1 Mus musculus 98-121 4066760-8 1985 To establish a possible link between early changes in cation fluxes and activation of gene expression by TPA, the induction of the enzyme ornithine decarboxylase (ODC) was studied in detail. Tetradecanoylphorbol Acetate 105-108 ornithine decarboxylase, structural 1 Mus musculus 138-161 4066760-8 1985 To establish a possible link between early changes in cation fluxes and activation of gene expression by TPA, the induction of the enzyme ornithine decarboxylase (ODC) was studied in detail. Tetradecanoylphorbol Acetate 105-108 ornithine decarboxylase, structural 1 Mus musculus 163-166 4075283-3 1985 The ability of ADR to deplete the intracellular level of GSH correlated with its ability to increase basal and TPA-induced ornithine decarboxylase (ODC, L-ornithine carboxylase, EC 4.1.1.17) activities. Tetradecanoylphorbol Acetate 111-114 ornithine decarboxylase, structural 1 Mus musculus 148-151 4075283-4 1985 In vivo, topical ADR treatments also enhanced TPA-induced ODC activity as well as the tumor-promoting ability of TPA in the two-stage system of mouse skin carcinogenesis. Tetradecanoylphorbol Acetate 46-49 ornithine decarboxylase, structural 1 Mus musculus 58-61 3926337-8 1985 The induction by DMBA of ornithine decarboxylase activity, a biochemical marker of tumor promoter activity, was not affected by CuDIPS; however, induction of ornithine decarboxylase by TPA was potently blocked. Tetradecanoylphorbol Acetate 185-188 ornithine decarboxylase, structural 1 Mus musculus 158-181 3864525-0 1985 Comparison of the inhibitory effects of retinoids on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activities in CD-1 and Sencar mice. Tetradecanoylphorbol Acetate 53-89 ornithine decarboxylase, structural 1 Mus musculus 108-131 2990757-4 1985 Application of alpha- and beta-CBT to mouse skin prior to treatment with TPA inhibited TPA-induced ODC activity. Tetradecanoylphorbol Acetate 73-76 ornithine decarboxylase, structural 1 Mus musculus 99-102 2990757-4 1985 Application of alpha- and beta-CBT to mouse skin prior to treatment with TPA inhibited TPA-induced ODC activity. Tetradecanoylphorbol Acetate 87-90 ornithine decarboxylase, structural 1 Mus musculus 99-102 3933814-1 1985 The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the non-promoter mezerein both induce ornithine decarboxylase activity in mouse epidermis by a route which can be blocked by indomethacin. Tetradecanoylphorbol Acetate 19-55 ornithine decarboxylase, structural 1 Mus musculus 104-127 3933814-1 1985 The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the non-promoter mezerein both induce ornithine decarboxylase activity in mouse epidermis by a route which can be blocked by indomethacin. Tetradecanoylphorbol Acetate 57-60 ornithine decarboxylase, structural 1 Mus musculus 104-127 2990757-5 1985 The degree of inhibition was dependent on the dose and application of 16.5 mumol/mouse of alpha- and beta-CBT resulted in a 50 and 40% reduction, respectively, of the maximum of the ODC activity induced as a result of treatment with TPA. Tetradecanoylphorbol Acetate 233-236 ornithine decarboxylase, structural 1 Mus musculus 182-185 2992824-1 1985 Previously it was shown that lipophilic analogs of a free-radical scavenger, 2(3)-tert-butyl-4-hydroxyanisole (BHA), inhibit ornithine decarboxylase (ODC) activity which is induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse epidermis. Tetradecanoylphorbol Acetate 184-220 ornithine decarboxylase, structural 1 Mus musculus 125-148 2861859-1 1985 The mechanisms by which topically applied retinoic acid to mouse skin inhibits tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced epidermal ornithine decarboxylase activity were analyzed. Tetradecanoylphorbol Acetate 94-130 ornithine decarboxylase, structural 1 Mus musculus 155-178 2861859-1 1985 The mechanisms by which topically applied retinoic acid to mouse skin inhibits tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced epidermal ornithine decarboxylase activity were analyzed. Tetradecanoylphorbol Acetate 132-135 ornithine decarboxylase, structural 1 Mus musculus 155-178 2861859-3 1985 In addition, inhibition of TPA-caused increased ornithine decarboxylase activity does not appear to be due to enhanced degradation and/or post-translational modification of ornithine decarboxylase by transglutaminase-mediated putrescine incorporation. Tetradecanoylphorbol Acetate 27-30 ornithine decarboxylase, structural 1 Mus musculus 48-71 2861859-4 1985 We found that retinoic acid inhibits the synthesis of ornithine decarboxylase caused by TPA. Tetradecanoylphorbol Acetate 88-91 ornithine decarboxylase, structural 1 Mus musculus 54-77 2861859-5 1985 Application of 10 nmol TPA to mouse skin led to a dramatic induction of epidermal ornithine decarboxylase activity which was paralled by increased [3H]difluoromethylornithine binding and an increased incorporation of [35S]methionine into the enzyme. Tetradecanoylphorbol Acetate 23-26 ornithine decarboxylase, structural 1 Mus musculus 82-105 2861859-6 1985 Application of 17 nmol retinoic acid 1 h prior to application of 10 nmol TPA to skin resulted in inhibition of the induction of activity which accompanied inhibition of [3H]difluoromethylornithine binding and [35S]methionine incorporation into ornithine decarboxylase protein as determined by the tube-gel electrophoresis of the enzyme immunoprecipitated with monoclonal antibodies to it. Tetradecanoylphorbol Acetate 73-76 ornithine decarboxylase, structural 1 Mus musculus 244-267 2861859-8 1985 The results indicate that retinoic acid possibly inhibits TPA-caused synthesis of ornithine decarboxylase protein selectively. Tetradecanoylphorbol Acetate 58-61 ornithine decarboxylase, structural 1 Mus musculus 82-105 2992824-1 1985 Previously it was shown that lipophilic analogs of a free-radical scavenger, 2(3)-tert-butyl-4-hydroxyanisole (BHA), inhibit ornithine decarboxylase (ODC) activity which is induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse epidermis. Tetradecanoylphorbol Acetate 184-220 ornithine decarboxylase, structural 1 Mus musculus 150-153 2992824-1 1985 Previously it was shown that lipophilic analogs of a free-radical scavenger, 2(3)-tert-butyl-4-hydroxyanisole (BHA), inhibit ornithine decarboxylase (ODC) activity which is induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse epidermis. Tetradecanoylphorbol Acetate 222-225 ornithine decarboxylase, structural 1 Mus musculus 125-148 2992824-1 1985 Previously it was shown that lipophilic analogs of a free-radical scavenger, 2(3)-tert-butyl-4-hydroxyanisole (BHA), inhibit ornithine decarboxylase (ODC) activity which is induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse epidermis. Tetradecanoylphorbol Acetate 222-225 ornithine decarboxylase, structural 1 Mus musculus 150-153 2992824-6 1985 The inhibitory activities of these analogs for lipid peroxidation were related to both their lipophilic and antioxidant properties and corresponded favorably with their inhibitory activities for TPA-induced ODC activities in mouse epidermis. Tetradecanoylphorbol Acetate 195-198 ornithine decarboxylase, structural 1 Mus musculus 207-210 2992824-8 1985 These results imply that lipophilic BHA analogs inhibit TPA-induced ODC activity by scavenging free radicals other than O-2. Tetradecanoylphorbol Acetate 56-59 ornithine decarboxylase, structural 1 Mus musculus 68-71 3158316-5 1985 These results suggest that the activation of protein kinase C is an initial and essential event in the process of ornithine decarboxylase induction caused by 12-O-tetradecanoyl-phorbol-13-acetate. Tetradecanoylphorbol Acetate 158-195 ornithine decarboxylase, structural 1 Mus musculus 114-137 3859699-8 1985 Thus human skin, like mouse skin, is responsive to TPA for ODC induction. Tetradecanoylphorbol Acetate 51-54 ornithine decarboxylase, structural 1 Mus musculus 59-62 6331639-0 1984 Induction of mouse brain ornithine decarboxylase by 12-O-tetradecanoylphorbol-13-acetate is independent of TPA receptor concentration. Tetradecanoylphorbol Acetate 52-88 ornithine decarboxylase, structural 1 Mus musculus 25-48 2859127-1 1985 The constituent amino acids of reduced glutathione (GSH), GSH itself, and D-alpha-tocopherol inhibited 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC, L-ornithine carboxy-lyase, EC 4.1.1.17) activity in mouse epidermis in vivo and in vitro. Tetradecanoylphorbol Acetate 142-145 ornithine decarboxylase, structural 1 Mus musculus 155-178 2859127-1 1985 The constituent amino acids of reduced glutathione (GSH), GSH itself, and D-alpha-tocopherol inhibited 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC, L-ornithine carboxy-lyase, EC 4.1.1.17) activity in mouse epidermis in vivo and in vitro. Tetradecanoylphorbol Acetate 142-145 ornithine decarboxylase, structural 1 Mus musculus 180-183 2859127-3 1985 Moreover, the ability of the constituent amino acids of GSH and GSH to inhibit TPA-induced ODC activity correlated well with their ability to increase the ratio of GSH/oxidized glutathione (GSSG) in isolated epidermal cells. Tetradecanoylphorbol Acetate 79-82 ornithine decarboxylase, structural 1 Mus musculus 91-94 2859127-5 1985 Since the inhibitory effects of Cys on both the decrease in the ratio of GSH/GSSG and the induction of ODC activity by TPA were greatly reduced by the inhibitors of gamma-glutamyl transpeptidase and gamma-glutamylcysteine synthetase, it is suggested that some of the inhibitory effects of Glu, Cys and Gly on tumor promotion could result from their interference with the metabolism of the tripeptide GSH, a natural antioxidant which inhibits chemical carcinogenesis. Tetradecanoylphorbol Acetate 119-122 ornithine decarboxylase, structural 1 Mus musculus 103-106 3156383-0 1985 Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Phorbol myristate acetate (TPA), a protein kinase C activator, stimulates ornithine decarboxylase (ODC) activity in mammary gland explants derived from 12-14 day pregnant mice. Tetradecanoylphorbol Acetate 126-151 ornithine decarboxylase, structural 1 Mus musculus 25-48 3156383-0 1985 Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Phorbol myristate acetate (TPA), a protein kinase C activator, stimulates ornithine decarboxylase (ODC) activity in mammary gland explants derived from 12-14 day pregnant mice. Tetradecanoylphorbol Acetate 126-151 ornithine decarboxylase, structural 1 Mus musculus 200-223 3156383-0 1985 Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Phorbol myristate acetate (TPA), a protein kinase C activator, stimulates ornithine decarboxylase (ODC) activity in mammary gland explants derived from 12-14 day pregnant mice. Tetradecanoylphorbol Acetate 126-151 ornithine decarboxylase, structural 1 Mus musculus 225-228 3156383-0 1985 Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Phorbol myristate acetate (TPA), a protein kinase C activator, stimulates ornithine decarboxylase (ODC) activity in mammary gland explants derived from 12-14 day pregnant mice. Tetradecanoylphorbol Acetate 153-156 ornithine decarboxylase, structural 1 Mus musculus 25-48 3156383-0 1985 Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Phorbol myristate acetate (TPA), a protein kinase C activator, stimulates ornithine decarboxylase (ODC) activity in mammary gland explants derived from 12-14 day pregnant mice. Tetradecanoylphorbol Acetate 153-156 ornithine decarboxylase, structural 1 Mus musculus 200-223 3156383-0 1985 Prolactin stimulation of ornithine decarboxylase activity in the mammary gland may involve an activation of protein kinase C. Phorbol myristate acetate (TPA), a protein kinase C activator, stimulates ornithine decarboxylase (ODC) activity in mammary gland explants derived from 12-14 day pregnant mice. Tetradecanoylphorbol Acetate 153-156 ornithine decarboxylase, structural 1 Mus musculus 225-228 2578899-4 1985 TPA application at day 7 evokes, however, (i) a hyperplastic reaction followed by a massive "psoriasis-like" hyperkeratosis, (ii) an increase of ornithine decarboxylase activity and (iii) a restoration of the neonatal keratin polypeptide pattern. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 145-168 3995502-0 1985 Inhibition of the effects of 12-O-tetradecanoylphorbol-13-acetate on mouse epidermal glutathione peroxidase and ornithine decarboxylase activities by glutathione level-raising agents and selenium-containing compounds. Tetradecanoylphorbol Acetate 29-65 ornithine decarboxylase, structural 1 Mus musculus 112-135 3995502-3 1985 The inhibitory effects of 0.2 mM cysteine (Cys) or 0.5 mM GSH and 2.5 microM Na2 SeO3 or 50 microM selenocystamine on TPA-decreased GSH peroxidase activity were additive, in relation with their additive inhibitory effects on TPA-induced ornithine decarboxylase (ODC) (L-ornithine carboxylase, EC 4.1.1.17) activity. Tetradecanoylphorbol Acetate 118-121 ornithine decarboxylase, structural 1 Mus musculus 237-260 3995502-3 1985 The inhibitory effects of 0.2 mM cysteine (Cys) or 0.5 mM GSH and 2.5 microM Na2 SeO3 or 50 microM selenocystamine on TPA-decreased GSH peroxidase activity were additive, in relation with their additive inhibitory effects on TPA-induced ornithine decarboxylase (ODC) (L-ornithine carboxylase, EC 4.1.1.17) activity. Tetradecanoylphorbol Acetate 118-121 ornithine decarboxylase, structural 1 Mus musculus 262-265 3970689-2 1985 In vitro, the addition of 12-0-tetradecanoylphorbol-13-acetate (TPA) to adult mouse skin pieces incubated at 37 degrees C in serum-free MEM led to a dramatic increase in epidermal ODC activity 5 hours following treatment. Tetradecanoylphorbol Acetate 64-67 ornithine decarboxylase, structural 1 Mus musculus 180-183 6331639-3 1984 TPA-dependent induction of ODC activity was maximal on days 5 and 9 postnatally while on day 7, the developmental (endogenous) level of ODC in brain was high and, concurrently, the ability of TPA to induce ODC was reduced. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 27-30 6331639-3 1984 TPA-dependent induction of ODC activity was maximal on days 5 and 9 postnatally while on day 7, the developmental (endogenous) level of ODC in brain was high and, concurrently, the ability of TPA to induce ODC was reduced. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 136-139 6331639-3 1984 TPA-dependent induction of ODC activity was maximal on days 5 and 9 postnatally while on day 7, the developmental (endogenous) level of ODC in brain was high and, concurrently, the ability of TPA to induce ODC was reduced. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 136-139 6331639-3 1984 TPA-dependent induction of ODC activity was maximal on days 5 and 9 postnatally while on day 7, the developmental (endogenous) level of ODC in brain was high and, concurrently, the ability of TPA to induce ODC was reduced. Tetradecanoylphorbol Acetate 192-195 ornithine decarboxylase, structural 1 Mus musculus 27-30 6331639-3 1984 TPA-dependent induction of ODC activity was maximal on days 5 and 9 postnatally while on day 7, the developmental (endogenous) level of ODC in brain was high and, concurrently, the ability of TPA to induce ODC was reduced. Tetradecanoylphorbol Acetate 192-195 ornithine decarboxylase, structural 1 Mus musculus 136-139 6331639-3 1984 TPA-dependent induction of ODC activity was maximal on days 5 and 9 postnatally while on day 7, the developmental (endogenous) level of ODC in brain was high and, concurrently, the ability of TPA to induce ODC was reduced. Tetradecanoylphorbol Acetate 192-195 ornithine decarboxylase, structural 1 Mus musculus 136-139 6331639-4 1984 Both TPA-dependent and developmental increases in mouse brain ODC activity were significantly reduced by intracisternal injection of retinoic acid (RA). Tetradecanoylphorbol Acetate 5-8 ornithine decarboxylase, structural 1 Mus musculus 62-65 6331639-5 1984 The efficacy of TPA in elevating ODC activity at postnatal ages 1-220 days-old was independent of both soluble-and particulate-associated TPA receptor concentration. Tetradecanoylphorbol Acetate 16-19 ornithine decarboxylase, structural 1 Mus musculus 33-36 6331639-7 1984 Furthermore, the endogenous mechanism of ODC induction is distinct from that of the TPA-dependent increase in ODC enzyme activity. Tetradecanoylphorbol Acetate 84-87 ornithine decarboxylase, structural 1 Mus musculus 110-113 6427052-0 1984 Effects of flavonoids and antioxidants on 12-O-tetradecanoyl-phorbol-13-acetate-caused epidermal ornithine decarboxylase induction and tumor promotion in relation to lipoxygenase inhibition by these compounds. Tetradecanoylphorbol Acetate 42-79 ornithine decarboxylase, structural 1 Mus musculus 97-120 6423272-3 1984 Application of 1 micrograms 1 alpha, 25(OH)2D3 within 30 min before or after treatment with 10 micrograms TPA caused about 72% inhibition of ODC induction at 4 hr. Tetradecanoylphorbol Acetate 106-109 ornithine decarboxylase, structural 1 Mus musculus 141-144 6423272-5 1984 The dose required for 50% inhibition was 0.063 micrograms, or 0.15 nmol, which is about one-half that of retinoic acid, a known inhibitor of induction of ODC activity by TPA. Tetradecanoylphorbol Acetate 170-173 ornithine decarboxylase, structural 1 Mus musculus 154-157 6322972-4 1984 Both cell lines responded to RA pretreatment with an increase in EGF- and TPA-induced ODC activity, without a concomitant increase in DNA synthesis in either cell line. Tetradecanoylphorbol Acetate 74-77 ornithine decarboxylase, structural 1 Mus musculus 86-89 6427052-1 1984 The effects of flavonoids, antioxidants and related compounds on 12-O-tetradecanoylphorbol-13-acetate (TPA)-caused epidermal ornithine decarboxylase (ODC) induction, DNA synthesis and skin tumor promotion, and on epidermal lipoxygenase activity, were investigated using CD-1 mice. Tetradecanoylphorbol Acetate 65-101 ornithine decarboxylase, structural 1 Mus musculus 125-148 6427052-1 1984 The effects of flavonoids, antioxidants and related compounds on 12-O-tetradecanoylphorbol-13-acetate (TPA)-caused epidermal ornithine decarboxylase (ODC) induction, DNA synthesis and skin tumor promotion, and on epidermal lipoxygenase activity, were investigated using CD-1 mice. Tetradecanoylphorbol Acetate 65-101 ornithine decarboxylase, structural 1 Mus musculus 150-153 6427052-1 1984 The effects of flavonoids, antioxidants and related compounds on 12-O-tetradecanoylphorbol-13-acetate (TPA)-caused epidermal ornithine decarboxylase (ODC) induction, DNA synthesis and skin tumor promotion, and on epidermal lipoxygenase activity, were investigated using CD-1 mice. Tetradecanoylphorbol Acetate 103-106 ornithine decarboxylase, structural 1 Mus musculus 150-153 6427052-4 1984 Similarly, morin, fisetin , kaempferol and n-propyl gallate markedly inhibited TPA-caused ODC induction. Tetradecanoylphorbol Acetate 79-82 ornithine decarboxylase, structural 1 Mus musculus 90-93 6427052-9 1984 Thus, the inhibitory effects of flavonoids and antioxidants on the TPA-caused ODC induction and tumor promotion were roughly parallel with their activities of lipoxygenase inhibition. Tetradecanoylphorbol Acetate 67-70 ornithine decarboxylase, structural 1 Mus musculus 78-81 6427052-10 1984 These results further support our hypothesis that a lipoxygenase product(s) is involved in the mechanism of TPA-caused ODC induction and tumor promotion. Tetradecanoylphorbol Acetate 108-111 ornithine decarboxylase, structural 1 Mus musculus 119-122 6315213-0 1983 Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis by sweetening agents and related compounds. Tetradecanoylphorbol Acetate 14-50 ornithine decarboxylase, structural 1 Mus musculus 59-82 6315223-7 1983 The magnitude of vesical ODC induction correlated well with the ability of a series of phorbol esters to promote mouse skin tumor formation (TPA greater than phorbol didecanoate greater than phorbol dibenzoate, and phorbol diacetate or phorbol did not induce bladder ODC activity). Tetradecanoylphorbol Acetate 141-144 ornithine decarboxylase, structural 1 Mus musculus 25-28 6315223-9 1983 Increased ODC activity by TPA was the result of an increased amount of ODC protein localized mostly (greater than 60%) in urinary bladder mucosa. Tetradecanoylphorbol Acetate 26-29 ornithine decarboxylase, structural 1 Mus musculus 10-13 6315223-9 1983 Increased ODC activity by TPA was the result of an increased amount of ODC protein localized mostly (greater than 60%) in urinary bladder mucosa. Tetradecanoylphorbol Acetate 26-29 ornithine decarboxylase, structural 1 Mus musculus 71-74 6315223-14 1983 Since TPA binds specifically to urinary bladder epithelium, and the induction of ODC activity is one of the properties of tumor promoters, one may conclude that TPA may promote urinary bladder carcinogenesis. Tetradecanoylphorbol Acetate 161-164 ornithine decarboxylase, structural 1 Mus musculus 81-84 6644098-0 1983 Effects of amino acid treatments on 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis in vivo and in vitro. Tetradecanoylphorbol Acetate 36-72 ornithine decarboxylase, structural 1 Mus musculus 81-104 6644098-4 1983 Arginine and its analog, canavanine, inhibited to the same degree TPA-induced ornithine decarboxylase activity, and potentiated to the same extent the inhibitory effects of glutamic acid, asparagine, and glycine on this enzyme. Tetradecanoylphorbol Acetate 66-69 ornithine decarboxylase, structural 1 Mus musculus 78-101 6640844-0 1983 The induction of ornithine decarboxylase by phorbol 12-myristate 13-acetate or by serum is inhibited by antioxidants. Tetradecanoylphorbol Acetate 44-75 ornithine decarboxylase, structural 1 Mus musculus 17-40 6640844-3 1983 Therefore, we have studied the effect of antioxidants on the induction of ODC by PMA, medium change only and medium change plus PMA in mouse mammary tumor cells Mm5mt/C1. Tetradecanoylphorbol Acetate 81-84 ornithine decarboxylase, structural 1 Mus musculus 74-77 6315213-1 1983 The effects of naturally occurring sweetening agents, which inhibited the induction of Epstein-Barr virus-associated early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), and related compounds on the induction of ornithine decarboxylase (ODC) by TPA is examined. Tetradecanoylphorbol Acetate 151-187 ornithine decarboxylase, structural 1 Mus musculus 237-260 6315213-2 1983 Application of glycyrrhetinic acid or steviol to mouse skin 1 h before TPA treatment showed a remarkable decrease in TPA-induced ODC activity. Tetradecanoylphorbol Acetate 71-74 ornithine decarboxylase, structural 1 Mus musculus 129-132 6315213-2 1983 Application of glycyrrhetinic acid or steviol to mouse skin 1 h before TPA treatment showed a remarkable decrease in TPA-induced ODC activity. Tetradecanoylphorbol Acetate 117-120 ornithine decarboxylase, structural 1 Mus musculus 129-132 6315213-3 1983 Post-treatment with glycyrrhetinic acid or steviol 1 h after application of TPA also resulted in a considerable depression in the induction of ODC activity. Tetradecanoylphorbol Acetate 76-79 ornithine decarboxylase, structural 1 Mus musculus 143-146 6315213-5 1983 These results suggest that glycyrrhetinic acid and steviol interfere with the process of induction of epidermal ODC by TPA treatment of mouse skin. Tetradecanoylphorbol Acetate 119-122 ornithine decarboxylase, structural 1 Mus musculus 112-115 6413085-2 1983 TPA (20 nmol/mouse)-induced epidermal ornithine decarboxylase (ODC) activity was also inhibited by quercetin (10-30 mumol/mouse), but it failed to inhibit the stimulation of epidermal DNA synthesis by TPA. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 38-61 6413085-2 1983 TPA (20 nmol/mouse)-induced epidermal ornithine decarboxylase (ODC) activity was also inhibited by quercetin (10-30 mumol/mouse), but it failed to inhibit the stimulation of epidermal DNA synthesis by TPA. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 63-66 6413085-2 1983 TPA (20 nmol/mouse)-induced epidermal ornithine decarboxylase (ODC) activity was also inhibited by quercetin (10-30 mumol/mouse), but it failed to inhibit the stimulation of epidermal DNA synthesis by TPA. Tetradecanoylphorbol Acetate 201-204 ornithine decarboxylase, structural 1 Mus musculus 63-66 6413085-5 1983 These results suggest that the inhibition of lipoxygenase by quercetin is one of the major actions of the above agent to inhibit tumor promotion and TPA-induced ODC activity. Tetradecanoylphorbol Acetate 149-152 ornithine decarboxylase, structural 1 Mus musculus 161-164 6616764-2 1983 In CFLP mice, which responded to carcinogen with development of lung-adenomas, a single topical application of TPA to hairless mouse skin increased ornithine decarboxylase activity in the lung. Tetradecanoylphorbol Acetate 111-114 ornithine decarboxylase, structural 1 Mus musculus 148-171 6850576-2 1983 Mice maintained on a diet containing 0.75% BHA for 8 days showed a 50% reduction in maximal ODC induction following treatment with TPA when compared to mice fed a control diet. Tetradecanoylphorbol Acetate 131-134 ornithine decarboxylase, structural 1 Mus musculus 92-95 6407752-1 1983 Application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin leads to a manifold induction of ornithine decarboxylase (ODC) activity within 5 hr and an increased accumulation of putrescine. Tetradecanoylphorbol Acetate 41-77 ornithine decarboxylase, structural 1 Mus musculus 131-154 6407752-1 1983 Application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin leads to a manifold induction of ornithine decarboxylase (ODC) activity within 5 hr and an increased accumulation of putrescine. Tetradecanoylphorbol Acetate 41-77 ornithine decarboxylase, structural 1 Mus musculus 156-159 6407752-1 1983 Application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin leads to a manifold induction of ornithine decarboxylase (ODC) activity within 5 hr and an increased accumulation of putrescine. Tetradecanoylphorbol Acetate 79-82 ornithine decarboxylase, structural 1 Mus musculus 131-154 6407752-1 1983 Application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin leads to a manifold induction of ornithine decarboxylase (ODC) activity within 5 hr and an increased accumulation of putrescine. Tetradecanoylphorbol Acetate 79-82 ornithine decarboxylase, structural 1 Mus musculus 156-159 6407752-4 1983 TPA-induced ODC activity and the accumulation of putrescine were almost completely inhibited. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 12-15 6850576-0 1983 Inhibition by 2(3)-tert-butyl-4-hydroxyanisole and other antioxidants of epidermal ornithine decarboxylase activity induced by 12-O-tetradecanoylphorbol-13-acetate. Tetradecanoylphorbol Acetate 127-163 ornithine decarboxylase, structural 1 Mus musculus 83-106 6850576-1 1983 The relationship between reactive oxygen and/or free radical species and tumor promotion was evaluated by investigating the inhibitory effects of 2(3)-tert-butyl-4-hydroxyanisole (BHA) and other antioxidants on the induction of ornithine decarboxylase (ODC) activity in mouse epidermis by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 307-343 ornithine decarboxylase, structural 1 Mus musculus 228-251 6850576-1 1983 The relationship between reactive oxygen and/or free radical species and tumor promotion was evaluated by investigating the inhibitory effects of 2(3)-tert-butyl-4-hydroxyanisole (BHA) and other antioxidants on the induction of ornithine decarboxylase (ODC) activity in mouse epidermis by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 345-348 ornithine decarboxylase, structural 1 Mus musculus 228-251 6850576-3 1983 Topical application of BHA (55 mumol) 30 min prior to TPA treatment (17 nmol) elicited an 80% inhibition of promoter-induced ODC activity. Tetradecanoylphorbol Acetate 54-57 ornithine decarboxylase, structural 1 Mus musculus 125-128 6850576-10 1983 Collectively, these results demonstrate an early and direct inhibition of TPA-induced ODC activity by lipophilic phenolic antioxidants and suggest a role for reactive oxygen and/or free radical species in tumor promotion. Tetradecanoylphorbol Acetate 74-77 ornithine decarboxylase, structural 1 Mus musculus 86-89 6831394-1 1983 Addition of the tumor promotor 12-O-tetradecanoyl phorbol-13-acetate (TPA) to serum-deprived mouse 3T3 cells resulted in an increase in ornithine decarboxylase activity which is maximal at 3 h and declined thereafter. Tetradecanoylphorbol Acetate 31-68 ornithine decarboxylase, structural 1 Mus musculus 136-159 6831394-1 1983 Addition of the tumor promotor 12-O-tetradecanoyl phorbol-13-acetate (TPA) to serum-deprived mouse 3T3 cells resulted in an increase in ornithine decarboxylase activity which is maximal at 3 h and declined thereafter. Tetradecanoylphorbol Acetate 70-73 ornithine decarboxylase, structural 1 Mus musculus 136-159 6833404-0 1983 Glucose uptake and ornithine decarboxylase activity in tetradecanoyl phorbol acetate non-proliferative variants. Tetradecanoylphorbol Acetate 55-84 ornithine decarboxylase, structural 1 Mus musculus 19-42 6833404-8 1983 Although an elevation of ornithine decarboxylase levels occurred in 3T3-TNR-2 cells treated with TPA, the maximal specific activity in the variant was less than the unstimulated value for 3T3 cells. Tetradecanoylphorbol Acetate 97-100 ornithine decarboxylase, structural 1 Mus musculus 25-48 6848192-12 1983 Additionally, there is a strain-related difference in sensitivity with regard to ODC-inducing activity of TPA in the livers of C57BL/6 and DBA/2 mice. Tetradecanoylphorbol Acetate 106-109 ornithine decarboxylase, structural 1 Mus musculus 81-84 6848192-4 1983 dose of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 micrograms/kg) enhanced the activity of ODC about 70-fold within 12 hr in C57BL/6 mice and 18-fold within 24 hr in DBA/2 mice without affecting AHH activity markedly. Tetradecanoylphorbol Acetate 27-63 ornithine decarboxylase, structural 1 Mus musculus 114-117 6848192-4 1983 dose of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 micrograms/kg) enhanced the activity of ODC about 70-fold within 12 hr in C57BL/6 mice and 18-fold within 24 hr in DBA/2 mice without affecting AHH activity markedly. Tetradecanoylphorbol Acetate 65-68 ornithine decarboxylase, structural 1 Mus musculus 114-117 6848192-5 1983 4-O-Methyl-12-O-tetradecanoylphorbol-13-acetate (100 micrograms/kg) raised ODC activity to about 25% of the TPA-treated value in C57BL/6 mice; in DBA/2 mice, TPA and 4-O-methyl-12-O-tetradecanoylphorbol-13-acetate induced ODC activity to roughly the same level. Tetradecanoylphorbol Acetate 108-111 ornithine decarboxylase, structural 1 Mus musculus 75-78 6848192-7 1983 The inducing effect of TPA on ODC activity was potentiated by a simultaneous administration of MC to C57BL/6 mice; combined TPA and TCDD to DBA/2 mice exerted an additive effect on hepatic ODC activity. Tetradecanoylphorbol Acetate 23-26 ornithine decarboxylase, structural 1 Mus musculus 30-33 6848192-7 1983 The inducing effect of TPA on ODC activity was potentiated by a simultaneous administration of MC to C57BL/6 mice; combined TPA and TCDD to DBA/2 mice exerted an additive effect on hepatic ODC activity. Tetradecanoylphorbol Acetate 23-26 ornithine decarboxylase, structural 1 Mus musculus 189-192 6848192-7 1983 The inducing effect of TPA on ODC activity was potentiated by a simultaneous administration of MC to C57BL/6 mice; combined TPA and TCDD to DBA/2 mice exerted an additive effect on hepatic ODC activity. Tetradecanoylphorbol Acetate 124-127 ornithine decarboxylase, structural 1 Mus musculus 189-192 6848192-9 1983 effectively inhibited the induction of ODC activity elicited by TPA, MC, or TCDD either alone or in various combinations but did not interfere with AHH induction. Tetradecanoylphorbol Acetate 64-67 ornithine decarboxylase, structural 1 Mus musculus 39-42 6848192-10 1983 These data indicate that different regulatory factors are involved in the ODC induction process elicited by TPA and polycyclic aromatic compounds and that MC and TCDD may induce ODC activity by different mechanisms. Tetradecanoylphorbol Acetate 108-111 ornithine decarboxylase, structural 1 Mus musculus 74-77 6185249-1 1983 Double applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin at intervals of greater than 48 h led to a larger induction of ornithine decarboxylase (ODC) and a smaller increase of DNA and RNA synthesis than did a single application. Tetradecanoylphorbol Acetate 23-59 ornithine decarboxylase, structural 1 Mus musculus 168-171 6185249-1 1983 Double applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin at intervals of greater than 48 h led to a larger induction of ornithine decarboxylase (ODC) and a smaller increase of DNA and RNA synthesis than did a single application. Tetradecanoylphorbol Acetate 61-64 ornithine decarboxylase, structural 1 Mus musculus 143-166 6185249-1 1983 Double applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin at intervals of greater than 48 h led to a larger induction of ornithine decarboxylase (ODC) and a smaller increase of DNA and RNA synthesis than did a single application. Tetradecanoylphorbol Acetate 23-59 ornithine decarboxylase, structural 1 Mus musculus 143-166 6185249-1 1983 Double applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin at intervals of greater than 48 h led to a larger induction of ornithine decarboxylase (ODC) and a smaller increase of DNA and RNA synthesis than did a single application. Tetradecanoylphorbol Acetate 61-64 ornithine decarboxylase, structural 1 Mus musculus 168-171 6872135-5 1983 Both HD and TPA stimulated maximal ODC activity 3-5 h after application, with epidermal ODC levels returning to basal levels within 12 h. The magnitude of ODC induction after multiple applications of HD was not as great as that observed for TPA. Tetradecanoylphorbol Acetate 12-15 ornithine decarboxylase, structural 1 Mus musculus 35-38 6240487-2 1983 The aim of the first approach was to obtain further evidence for the possible relevance of the induction of ornithine decarboxylase (ODC) activity to tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin. Tetradecanoylphorbol Acetate 169-205 ornithine decarboxylase, structural 1 Mus musculus 108-131 6872135-6 1983 Single skin applications of TPA and HD also transiently elevated hepatic ODC levels 27- and 7-fold, respectively; however, liver ODC activity did not increase following multiple applications of either chemical. Tetradecanoylphorbol Acetate 28-31 ornithine decarboxylase, structural 1 Mus musculus 73-76 6884565-0 1983 Purification of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase from mouse epidermis. Tetradecanoylphorbol Acetate 16-52 ornithine decarboxylase, structural 1 Mus musculus 61-84 6884565-1 1983 Ornithine decarboxylase was purified at least 1500-fold from mouse epidermis pretreated with five consecutive doses of 12-O-tetradecanoylphorbol-13-acetate and 3-isobutyl-1-methylxanthine at 3- to 4-day intervals. Tetradecanoylphorbol Acetate 119-155 ornithine decarboxylase, structural 1 Mus musculus 0-23 6240487-2 1983 The aim of the first approach was to obtain further evidence for the possible relevance of the induction of ornithine decarboxylase (ODC) activity to tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin. Tetradecanoylphorbol Acetate 169-205 ornithine decarboxylase, structural 1 Mus musculus 133-136 6240487-2 1983 The aim of the first approach was to obtain further evidence for the possible relevance of the induction of ornithine decarboxylase (ODC) activity to tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin. Tetradecanoylphorbol Acetate 207-210 ornithine decarboxylase, structural 1 Mus musculus 108-131 6240487-2 1983 The aim of the first approach was to obtain further evidence for the possible relevance of the induction of ornithine decarboxylase (ODC) activity to tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) in mouse skin. Tetradecanoylphorbol Acetate 207-210 ornithine decarboxylase, structural 1 Mus musculus 133-136 6240487-3 1983 The irreversible inhibitor of ODC activity, alpha-difluoromethylornithine, not only prevented ODC activity in a dose-dependent manner following skin application, it also prevented skin tumor promotion by TPA. Tetradecanoylphorbol Acetate 204-207 ornithine decarboxylase, structural 1 Mus musculus 30-33 6959135-1 1982 Addition of 12-tetradecanoylphorbol 13-acetate (TPA) to cultures of intact Swiss mouse 3T3 fibroblasts induced a dose-dependent increase in ornithine decarboxylase (OrnDCase) activity. Tetradecanoylphorbol Acetate 12-46 ornithine decarboxylase, structural 1 Mus musculus 165-173 6959135-1 1982 Addition of 12-tetradecanoylphorbol 13-acetate (TPA) to cultures of intact Swiss mouse 3T3 fibroblasts induced a dose-dependent increase in ornithine decarboxylase (OrnDCase) activity. Tetradecanoylphorbol Acetate 48-51 ornithine decarboxylase, structural 1 Mus musculus 140-163 6959135-1 1982 Addition of 12-tetradecanoylphorbol 13-acetate (TPA) to cultures of intact Swiss mouse 3T3 fibroblasts induced a dose-dependent increase in ornithine decarboxylase (OrnDCase) activity. Tetradecanoylphorbol Acetate 12-46 ornithine decarboxylase, structural 1 Mus musculus 140-163 6959135-1 1982 Addition of 12-tetradecanoylphorbol 13-acetate (TPA) to cultures of intact Swiss mouse 3T3 fibroblasts induced a dose-dependent increase in ornithine decarboxylase (OrnDCase) activity. Tetradecanoylphorbol Acetate 48-51 ornithine decarboxylase, structural 1 Mus musculus 165-173 6805948-0 1982 Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by phospholipase A2 inhibitors and lipoxygenase inhibitor. Tetradecanoylphorbol Acetate 14-50 ornithine decarboxylase, structural 1 Mus musculus 69-92 6805948-4 1982 Treatment of mice with tetracaine (20 and 100 mumol/mouse), a nonspecific phospholipase A2 inhibitor, inhibited the induction of ODC by TPA. Tetradecanoylphorbol Acetate 136-139 ornithine decarboxylase, structural 1 Mus musculus 129-132 6805948-1 1982 Application of 12-O-tetradecanoylphorbol-13-acetate (TPA; 20 nmol/mouse), a tumor-promoting agent, to mouse skin results in an induction of epidermal ornithine decarboxylase (ODC; EC 4.1.1.17). Tetradecanoylphorbol Acetate 15-51 ornithine decarboxylase, structural 1 Mus musculus 150-173 6805948-6 1982 The TPA-induced ODC inhibited by mepacrine was not restored by the treatment of mice with PGE2. Tetradecanoylphorbol Acetate 4-7 ornithine decarboxylase, structural 1 Mus musculus 16-19 6805948-1 1982 Application of 12-O-tetradecanoylphorbol-13-acetate (TPA; 20 nmol/mouse), a tumor-promoting agent, to mouse skin results in an induction of epidermal ornithine decarboxylase (ODC; EC 4.1.1.17). Tetradecanoylphorbol Acetate 15-51 ornithine decarboxylase, structural 1 Mus musculus 175-178 6805948-7 1982 TPA-induced ODC inhibited by either mepacrine or p-bromophenacyl bromide was partially but significantly restored by treatment with arachidonic acid (1 to 40 mumol/mouse). Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 12-15 6805948-1 1982 Application of 12-O-tetradecanoylphorbol-13-acetate (TPA; 20 nmol/mouse), a tumor-promoting agent, to mouse skin results in an induction of epidermal ornithine decarboxylase (ODC; EC 4.1.1.17). Tetradecanoylphorbol Acetate 53-56 ornithine decarboxylase, structural 1 Mus musculus 150-173 6805948-9 1982 Treatment of mice with nordihydroguaiaretic acid (10 to 90 mumol/mouse), a lipoxygenase inhibitor, also inhibited the induction of ODC by TPA. Tetradecanoylphorbol Acetate 138-141 ornithine decarboxylase, structural 1 Mus musculus 131-134 6805948-1 1982 Application of 12-O-tetradecanoylphorbol-13-acetate (TPA; 20 nmol/mouse), a tumor-promoting agent, to mouse skin results in an induction of epidermal ornithine decarboxylase (ODC; EC 4.1.1.17). Tetradecanoylphorbol Acetate 53-56 ornithine decarboxylase, structural 1 Mus musculus 175-178 6805948-10 1982 These results strongly indicate that the stimulation of phospholipase A2 activity is a crucial process in inducing mouse epidermal ODC by TPA and not only cyclooxygenase product (i.e., PGE2) but also lipoxygenase product(s) are involved in the mechanism of ODC induction. Tetradecanoylphorbol Acetate 138-141 ornithine decarboxylase, structural 1 Mus musculus 131-134 6805948-2 1982 Induction of ODC by TPA was inhibited by treatment of skin with indomethacin (1.12 mumol/mouse), a cyclooxygenase inhibitor, and the ODC activity suppressed by indomethacin was completely restored by concurrent application of prostaglandin E2 (PGE2) (140 nmol/mouse) as described first by Verma et al. Tetradecanoylphorbol Acetate 20-23 ornithine decarboxylase, structural 1 Mus musculus 13-16 6805948-11 1982 Our present data also suggest that the above arachidonate metabolites are essential but not sufficient factors for the TPA-stimulated induction of ODC. Tetradecanoylphorbol Acetate 119-122 ornithine decarboxylase, structural 1 Mus musculus 147-150 6805948-2 1982 Induction of ODC by TPA was inhibited by treatment of skin with indomethacin (1.12 mumol/mouse), a cyclooxygenase inhibitor, and the ODC activity suppressed by indomethacin was completely restored by concurrent application of prostaglandin E2 (PGE2) (140 nmol/mouse) as described first by Verma et al. Tetradecanoylphorbol Acetate 20-23 ornithine decarboxylase, structural 1 Mus musculus 133-136 7116338-1 1982 The effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) and 3-methyl-cholanthrene (MC) on ornithine decarboxylase (ODC) and aryl hydrocarbon hydroxylase (AHH) activities were studied in C57BL/6 mouse dermal fibroblasts in culture. Tetradecanoylphorbol Acetate 15-51 ornithine decarboxylase, structural 1 Mus musculus 92-115 7116338-1 1982 The effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) and 3-methyl-cholanthrene (MC) on ornithine decarboxylase (ODC) and aryl hydrocarbon hydroxylase (AHH) activities were studied in C57BL/6 mouse dermal fibroblasts in culture. Tetradecanoylphorbol Acetate 53-56 ornithine decarboxylase, structural 1 Mus musculus 92-115 7116338-0 1982 Dissociation of 12-O-tetradecanoylphorbol-13-acetate and 3-methylcholanthrene-induced induction in ornithine decarboxylase and aryl hydrocarbon hydroxylase activities in C57BL/6 mouse dermal fibroblasts in culture. Tetradecanoylphorbol Acetate 16-52 ornithine decarboxylase, structural 1 Mus musculus 99-122 7116338-2 1982 TPA selectively induced ODC activity and MC selectively induced AHH activity in these cells. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 24-27 7083472-4 1982 Retinoic acid inhibited the TPA-induced ODC activity and the ensuing accumulation of putrescine, but did not alter the TPA-induced SAM-D activity or the molar ratio of spermidine/spermine. Tetradecanoylphorbol Acetate 28-31 ornithine decarboxylase, structural 1 Mus musculus 40-43 7068980-1 1982 The tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) causes a dose-dependent induction (up to 300-fold) of ornithine decarboxylase activity in the epidermis of intact mice within 5 hours after the application to the skin of from 1 to 10 nmoles of the ester in 0.2 ml of acetone. Tetradecanoylphorbol Acetate 35-71 ornithine decarboxylase, structural 1 Mus musculus 132-155 7068980-1 1982 The tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) causes a dose-dependent induction (up to 300-fold) of ornithine decarboxylase activity in the epidermis of intact mice within 5 hours after the application to the skin of from 1 to 10 nmoles of the ester in 0.2 ml of acetone. Tetradecanoylphorbol Acetate 73-76 ornithine decarboxylase, structural 1 Mus musculus 132-155 7116561-8 1982 This is in contrast with the well documented activation of ODC in mouse skin treated with TPA. Tetradecanoylphorbol Acetate 90-93 ornithine decarboxylase, structural 1 Mus musculus 59-62 7116561-9 1982 Since TPA acts as a promoter in the mouse whereas both croton oil and TPA have no promoting action in the guinea pig, the above result supports the view that ODC activationis related to promotion, and provides a possible explanation for the resistance of this animal species to promotion. Tetradecanoylphorbol Acetate 6-9 ornithine decarboxylase, structural 1 Mus musculus 158-161 6817941-0 1982 Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity by lipoxygenase inhibitors: possible role of product(s) of lipoxygenase pathway. Tetradecanoylphorbol Acetate 14-50 ornithine decarboxylase, structural 1 Mus musculus 69-92 7083472-7 1982 Hence, at four levels of retinoic acid (0.17, 1.70, 17.0 and 170 nmol), which all inhibited the TPA-induced ODC effectively, there was no change in the total number of basal cells that divided during 16-48 h after TPA-application. Tetradecanoylphorbol Acetate 96-99 ornithine decarboxylase, structural 1 Mus musculus 108-111 6261139-3 1981 The recently discovered class of tumour promoters, the teleocidins, are as potent as TPA in the induction of ornithine decarboxylase in mouse skin, the inhibition of differentiation of Friend erythroleukaemia cells, the induction of HL-60 cell adhesion and the promotion of tumours on mouse skin. Tetradecanoylphorbol Acetate 85-88 ornithine decarboxylase, structural 1 Mus musculus 109-132 6817941-3 1982 Inhibition of TPA-induced ODC by indomethacin (1.12 mumol/mouse), a selective cyclooxygenase inhibitor, was counteracted by prostaglandin E2 (PGE2) (140 nmol/mouse). Tetradecanoylphorbol Acetate 14-17 ornithine decarboxylase, structural 1 Mus musculus 26-29 6817941-7 1982 Thus, the suppressive effect of nordihydroguaiaretic acid or phenidone on the ODC induction by TPA would be due to the inhibition of lipoxygenase. Tetradecanoylphorbol Acetate 95-98 ornithine decarboxylase, structural 1 Mus musculus 78-81 7295793-0 1981 Characterization of arginase activity from mouse epidermis and its relation to ornithine decarboxylase induction by the tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate. Tetradecanoylphorbol Acetate 143-179 ornithine decarboxylase, structural 1 Mus musculus 79-102 7251684-0 1981 The tumor promoter 12-O-tetradecanoylphorbol-13-acetate induces ornithine decarboxylase in proliferating basal cells but not in differentiating cells from mouse epidermis. Tetradecanoylphorbol Acetate 19-55 ornithine decarboxylase, structural 1 Mus musculus 64-87 7251684-3 1981 This model was utilized to determine which cell type in mouse epidermis responds to the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), by an induction of the enzyme ornithine decarboxylase (ODC). Tetradecanoylphorbol Acetate 118-154 ornithine decarboxylase, structural 1 Mus musculus 192-215 7251684-3 1981 This model was utilized to determine which cell type in mouse epidermis responds to the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), by an induction of the enzyme ornithine decarboxylase (ODC). Tetradecanoylphorbol Acetate 118-154 ornithine decarboxylase, structural 1 Mus musculus 217-220 7251684-3 1981 This model was utilized to determine which cell type in mouse epidermis responds to the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), by an induction of the enzyme ornithine decarboxylase (ODC). Tetradecanoylphorbol Acetate 156-159 ornithine decarboxylase, structural 1 Mus musculus 192-215 7251684-3 1981 This model was utilized to determine which cell type in mouse epidermis responds to the phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), by an induction of the enzyme ornithine decarboxylase (ODC). Tetradecanoylphorbol Acetate 156-159 ornithine decarboxylase, structural 1 Mus musculus 217-220 7251684-4 1981 Previous data had shown that TPA induces ODC in primary mouse epidermal cells only during the first 36 hr after plating in medium containing 1.44 mM Ca2+. Tetradecanoylphorbol Acetate 29-32 ornithine decarboxylase, structural 1 Mus musculus 41-44 7251684-8 1981 These results strongly suggest that the basal cells of the epidermis constitute the major target cells for the induction of ODC by TPA. Tetradecanoylphorbol Acetate 131-134 ornithine decarboxylase, structural 1 Mus musculus 124-127 7306036-3 1981 In experiments designed to test this contention, it was found that addition of TPA (1 microM to 1 nM) to confluent mouse 3T3 fibroblasts successively caused the release of prostaglandins E2 and I2, induction of the enzyme ornithine decarboxylase (EC 4.1.1.17), stimulation of [3H]thymidine incorporation into DNA, and cell proliferation. Tetradecanoylphorbol Acetate 79-82 ornithine decarboxylase, structural 1 Mus musculus 222-245 7306036-7 1981 Pretreatment of the cells with 1,3-diaminopropane (1 mM) or alpha-methylornithine (5 mM), inhibitors of polyamine synthesis, decreased TPA-induced ornithine decarboxylase activity without affecting DNA synthesis. Tetradecanoylphorbol Acetate 135-138 ornithine decarboxylase, structural 1 Mus musculus 147-170 7306036-8 1981 TPA stimulated [3H]thymidine incorporation into DNA, even when the ornithine decarboxylase activity was completely blocked. Tetradecanoylphorbol Acetate 0-3 ornithine decarboxylase, structural 1 Mus musculus 67-90 7248923-1 1981 Addition of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to a murine epidermal cell line leads to an early induction of the arachidonic acid cascade as measured by the release of [14C]arachidonic acid and [14C]prostaglandin E2 into the medium, to an induction of the ornithine decarboxylase and finally to cell proliferation. Tetradecanoylphorbol Acetate 30-66 ornithine decarboxylase, structural 1 Mus musculus 283-306 7448785-4 1981 12-O-Tetradecanoylphorbol-13-acetate, a potent promoter in mouse skin carcinogenesis, induced a 39-fold increase in ornithine decarboxylase activity, the best response among the various substances tested. Tetradecanoylphorbol Acetate 0-36 ornithine decarboxylase, structural 1 Mus musculus 116-139 7248923-1 1981 Addition of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to a murine epidermal cell line leads to an early induction of the arachidonic acid cascade as measured by the release of [14C]arachidonic acid and [14C]prostaglandin E2 into the medium, to an induction of the ornithine decarboxylase and finally to cell proliferation. Tetradecanoylphorbol Acetate 68-71 ornithine decarboxylase, structural 1 Mus musculus 283-306 7273334-7 1981 The relation between the rate of DNA-synthesis and the spermidine/spermine ratio as well as the ordered time sequence for the accumulation of putrescine and the induction of ODC and SAM-D activities, suggest a strong interdependence and a strict regulation of these events in hairless mouse epidermis induced to proliferate by TPA. Tetradecanoylphorbol Acetate 327-330 ornithine decarboxylase, structural 1 Mus musculus 174-177 6116315-0 1981 Inhibition by epidermal extracts of the 12-O-tetradecanoylphorbol-13-acetate induced peak of ornithine decarboxylase activity in the mouse epidermis. Tetradecanoylphorbol Acetate 40-76 ornithine decarboxylase, structural 1 Mus musculus 93-116 7328673-8 1981 ODC induction after exposure to 12-0-tetradecanoylphorbol-13-acetate (TPA) in basal cells is enhanced 20-fold over the response of a culture population containing both differentiating and basal cells. Tetradecanoylphorbol Acetate 70-73 ornithine decarboxylase, structural 1 Mus musculus 0-3 7328673-11 1981 After exposure to low concentrations of TPA or to weak promoters of the phorbol ester series, ODC activity is maximal at 3 hr. Tetradecanoylphorbol Acetate 40-43 ornithine decarboxylase, structural 1 Mus musculus 94-97 7328673-12 1981 With higher concentrations of TPA, the ODC maximum is at 9 hr. Tetradecanoylphorbol Acetate 30-33 ornithine decarboxylase, structural 1 Mus musculus 39-42 6116315-7 1981 Following the administration of epidermal extracts, the inhibition of the TPA-induced ODC-response correlated positively with the presence of epidermal G2-chalone activity (determined by a stathmokinetic method) whereas myocardial, skeletal muscle, or heat-inactivated epidermal extracts with no epidermal G2-chalone activity, had no effect on TPA-induced ODC activity. Tetradecanoylphorbol Acetate 344-347 ornithine decarboxylase, structural 1 Mus musculus 86-89 7448761-0 1981 Paradoxical effect of anthralin on 12-O-tetradecanoylphorbol-13-acetate-induced mouse epidermal ornithine decarboxylase activity, proliferation, and tumor promotion. Tetradecanoylphorbol Acetate 35-71 ornithine decarboxylase, structural 1 Mus musculus 96-119 7448775-0 1981 Differential retinoic acid inhibition of ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate and by germicidal ultraviolet light. Tetradecanoylphorbol Acetate 78-114 ornithine decarboxylase, structural 1 Mus musculus 41-64 7448775-3 1981 It was found that the induction of ODC by TPA is almost completely prevented by 0.1 to 1 microM retinoic acid while the induction by UV is only moderately inhibited. Tetradecanoylphorbol Acetate 42-45 ornithine decarboxylase, structural 1 Mus musculus 35-38 7448775-7 1981 Other agents known to modulate the induction of ODC by TPA (fluocinolone acetonide, tosyl-L-lysylchloromethane, and local anesthetics) do not act differentially on UV induction. Tetradecanoylphorbol Acetate 55-58 ornithine decarboxylase, structural 1 Mus musculus 48-51 7448775-8 1981 These agents possibly act at transcription or translation, both of which are required for ODC induction by TPA or UV. Tetradecanoylphorbol Acetate 107-110 ornithine decarboxylase, structural 1 Mus musculus 90-93 7448775-9 1981 The preferential inhibition by retinoic acid of ODC induction by TPA is interpreted to result from specific interference at a unique and early site of interaction of TPA with the cell. Tetradecanoylphorbol Acetate 65-68 ornithine decarboxylase, structural 1 Mus musculus 48-51 7448775-9 1981 The preferential inhibition by retinoic acid of ODC induction by TPA is interpreted to result from specific interference at a unique and early site of interaction of TPA with the cell. Tetradecanoylphorbol Acetate 166-169 ornithine decarboxylase, structural 1 Mus musculus 48-51 6116315-2 1981 4.1.117) (ODC) activity following a single topical application of 17 nmoles of 12-O-tetradecanoylphorbol-13-acetate (TPA) on hairless mouse skin was established. Tetradecanoylphorbol Acetate 79-115 ornithine decarboxylase, structural 1 Mus musculus 10-13 6116315-2 1981 4.1.117) (ODC) activity following a single topical application of 17 nmoles of 12-O-tetradecanoylphorbol-13-acetate (TPA) on hairless mouse skin was established. Tetradecanoylphorbol Acetate 117-120 ornithine decarboxylase, structural 1 Mus musculus 10-13 6116315-7 1981 Following the administration of epidermal extracts, the inhibition of the TPA-induced ODC-response correlated positively with the presence of epidermal G2-chalone activity (determined by a stathmokinetic method) whereas myocardial, skeletal muscle, or heat-inactivated epidermal extracts with no epidermal G2-chalone activity, had no effect on TPA-induced ODC activity. Tetradecanoylphorbol Acetate 74-77 ornithine decarboxylase, structural 1 Mus musculus 86-89 6116315-7 1981 Following the administration of epidermal extracts, the inhibition of the TPA-induced ODC-response correlated positively with the presence of epidermal G2-chalone activity (determined by a stathmokinetic method) whereas myocardial, skeletal muscle, or heat-inactivated epidermal extracts with no epidermal G2-chalone activity, had no effect on TPA-induced ODC activity. Tetradecanoylphorbol Acetate 74-77 ornithine decarboxylase, structural 1 Mus musculus 356-359 7471050-1 1980 The induction of epidermal ornithine decarboxylase (EC 4.1.1.17) (ODC) following topical application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mice can be inhibited by topical application of putrescine, the product of the enzyme. Tetradecanoylphorbol Acetate 130-166 ornithine decarboxylase, structural 1 Mus musculus 27-50 7471050-1 1980 The induction of epidermal ornithine decarboxylase (EC 4.1.1.17) (ODC) following topical application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mice can be inhibited by topical application of putrescine, the product of the enzyme. Tetradecanoylphorbol Acetate 130-166 ornithine decarboxylase, structural 1 Mus musculus 66-69 7471050-6 1980 Mixing of soluble extracts from TPA-treated mouse epidermis posttreated either with acetone or putrescine or with mouse epidermis treated with putrescine alone gave essentially additive ODC activity. Tetradecanoylphorbol Acetate 32-35 ornithine decarboxylase, structural 1 Mus musculus 186-189 7471050-1 1980 The induction of epidermal ornithine decarboxylase (EC 4.1.1.17) (ODC) following topical application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mice can be inhibited by topical application of putrescine, the product of the enzyme. Tetradecanoylphorbol Acetate 168-171 ornithine decarboxylase, structural 1 Mus musculus 27-50 7471050-1 1980 The induction of epidermal ornithine decarboxylase (EC 4.1.1.17) (ODC) following topical application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mice can be inhibited by topical application of putrescine, the product of the enzyme. Tetradecanoylphorbol Acetate 168-171 ornithine decarboxylase, structural 1 Mus musculus 66-69 7471050-2 1980 The degree of inhibition depended on both the dose and the time of putrescine application; application of 20 mumol of putrescine 2 hr after TPA treatment inhibited the induction of ODC activity by 50%. Tetradecanoylphorbol Acetate 140-143 ornithine decarboxylase, structural 1 Mus musculus 181-184 7471050-5 1980 Putrescine, when added directly to the assay medium at a 100-mumol dose level inhibited by 97% the TPA-induced ODC activity, but the amount of putrescine (20 mumol) which gave 50% inhibition of the induction of ODC activity in vivo had no effect when added to the assay system. Tetradecanoylphorbol Acetate 99-102 ornithine decarboxylase, structural 1 Mus musculus 111-114 7471050-5 1980 Putrescine, when added directly to the assay medium at a 100-mumol dose level inhibited by 97% the TPA-induced ODC activity, but the amount of putrescine (20 mumol) which gave 50% inhibition of the induction of ODC activity in vivo had no effect when added to the assay system. Tetradecanoylphorbol Acetate 99-102 ornithine decarboxylase, structural 1 Mus musculus 211-214 6168406-1 1980 12-O-Tetradecanoylphorbol-13-acetate (TPA) and mezerein (MZ) are diterpene esters of similar structure and approximately equipotent on a molar basis as far as their hyperplasiogenic, inflammatory, and induction of ornithine decarboxylase activity effects in mouse skin are concerned. Tetradecanoylphorbol Acetate 0-36 ornithine decarboxylase, structural 1 Mus musculus 214-237 6933562-0 1980 Local anesthetics inhibit induction of ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. Tetradecanoylphorbol Acetate 85-121 ornithine decarboxylase, structural 1 Mus musculus 39-62 6933562-1 1980 The induction of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) activity in mouse epidermal cells in vivo and in vitro occurs rapidly after exposure to the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA). Tetradecanoylphorbol Acetate 189-225 ornithine decarboxylase, structural 1 Mus musculus 17-40 6933562-1 1980 The induction of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) activity in mouse epidermal cells in vivo and in vitro occurs rapidly after exposure to the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA). Tetradecanoylphorbol Acetate 227-230 ornithine decarboxylase, structural 1 Mus musculus 17-40 7388798-4 1980 5,6-Epoxyretinoic acid, 5,6-dihydroretinoic acid, and retinoic acid were equally effective in inhibiting the induction of ODC activity by TPA. Tetradecanoylphorbol Acetate 138-141 ornithine decarboxylase, structural 1 Mus musculus 122-125 7388798-6 1980 These results indicate that (a) epoxidation of retinoic acid at the 5,6-position is not a rate-limiting modification for the anti-promoting activity of retinoic acid and that (b) inhibition of the induction by TPA of mouse epidermal ODC activity may be a simple test for screening the potential prophylactic activities of new retinoids. Tetradecanoylphorbol Acetate 210-213 ornithine decarboxylase, structural 1 Mus musculus 233-236 6168406-1 1980 12-O-Tetradecanoylphorbol-13-acetate (TPA) and mezerein (MZ) are diterpene esters of similar structure and approximately equipotent on a molar basis as far as their hyperplasiogenic, inflammatory, and induction of ornithine decarboxylase activity effects in mouse skin are concerned. Tetradecanoylphorbol Acetate 38-41 ornithine decarboxylase, structural 1 Mus musculus 214-237 679197-0 1978 Effects of retinoic acid and juvenile hormone on the induction of ornithine decarboxylase activity by 12-O-tetradecanoylphorbol-13-acetate. Tetradecanoylphorbol Acetate 102-138 ornithine decarboxylase, structural 1 Mus musculus 66-89 22283009-7 1980 A good correlation was observed between the induction of ornithine decarboxylase (ODC) activity and the formation of skin tumors by various doses of TPA. Tetradecanoylphorbol Acetate 149-152 ornithine decarboxylase, structural 1 Mus musculus 57-80 22283009-7 1980 A good correlation was observed between the induction of ornithine decarboxylase (ODC) activity and the formation of skin tumors by various doses of TPA. Tetradecanoylphorbol Acetate 149-152 ornithine decarboxylase, structural 1 Mus musculus 82-85 22283009-13 1980 The results indicate that a) the incidence of papillomas serves as a rapid (18 weeks) index for subsequent appearance of carcinomas, b) twice weekly applications of 10 nmol of TPA for 18 weeks following initiation of female CD-1 mice with 0.2 micromol of DMBA is an appropriate protocol for maximum tumor yield in initiation-promotion experiments, and c) ODC induction may be an important component of the mechanism of skin tumor promotion by TPA. Tetradecanoylphorbol Acetate 176-179 ornithine decarboxylase, structural 1 Mus musculus 355-358 498078-0 1979 Ornithine decarboxylase activity and DNA synthesis after treatment of cells in culture with 12-O-tetradecanoylphorbol-13-acetate. Tetradecanoylphorbol Acetate 92-128 ornithine decarboxylase, structural 1 Mus musculus 0-23 498078-1 1979 The ability of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce the enzyme ornithine decarboxylase (ODC) and to stimulate DNA synthesis was studied in four different cell types in vitro. Tetradecanoylphorbol Acetate 34-70 ornithine decarboxylase, structural 1 Mus musculus 98-121 498078-1 1979 The ability of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce the enzyme ornithine decarboxylase (ODC) and to stimulate DNA synthesis was studied in four different cell types in vitro. Tetradecanoylphorbol Acetate 34-70 ornithine decarboxylase, structural 1 Mus musculus 123-126 498078-1 1979 The ability of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce the enzyme ornithine decarboxylase (ODC) and to stimulate DNA synthesis was studied in four different cell types in vitro. Tetradecanoylphorbol Acetate 72-75 ornithine decarboxylase, structural 1 Mus musculus 98-121 498078-1 1979 The ability of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) to induce the enzyme ornithine decarboxylase (ODC) and to stimulate DNA synthesis was studied in four different cell types in vitro. Tetradecanoylphorbol Acetate 72-75 ornithine decarboxylase, structural 1 Mus musculus 123-126 498078-2 1979 The effects of this agent on each cell type were different: (a) in hamster embryo cells, TPA induced ODC but had no effect on DNA synthesis; (b) TPA induced ODC and stimulated DNA synthesis in BALB/c 3T3 mouse cells; (c) it did not induce ODC in human fibroblasts but did stimulate DNA synthesis; and (d) it induced neither ODC nor DNA synthesis in rat embryo fibroblasts. Tetradecanoylphorbol Acetate 89-92 ornithine decarboxylase, structural 1 Mus musculus 101-104 498078-2 1979 The effects of this agent on each cell type were different: (a) in hamster embryo cells, TPA induced ODC but had no effect on DNA synthesis; (b) TPA induced ODC and stimulated DNA synthesis in BALB/c 3T3 mouse cells; (c) it did not induce ODC in human fibroblasts but did stimulate DNA synthesis; and (d) it induced neither ODC nor DNA synthesis in rat embryo fibroblasts. Tetradecanoylphorbol Acetate 145-148 ornithine decarboxylase, structural 1 Mus musculus 157-160 498078-2 1979 The effects of this agent on each cell type were different: (a) in hamster embryo cells, TPA induced ODC but had no effect on DNA synthesis; (b) TPA induced ODC and stimulated DNA synthesis in BALB/c 3T3 mouse cells; (c) it did not induce ODC in human fibroblasts but did stimulate DNA synthesis; and (d) it induced neither ODC nor DNA synthesis in rat embryo fibroblasts. Tetradecanoylphorbol Acetate 145-148 ornithine decarboxylase, structural 1 Mus musculus 157-160 336799-3 1977 The recoveries of DNA, RNA, and protein on a per area basis were the same for the microwave and conventional heat separation procedures, and the TPA-induced ornithine decarboxylase levels were comparable. Tetradecanoylphorbol Acetate 145-148 ornithine decarboxylase, structural 1 Mus musculus 157-180 626983-0 1978 Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis by vitamin A analogs (retinoids). Tetradecanoylphorbol Acetate 14-50 ornithine decarboxylase, structural 1 Mus musculus 59-82 861945-0 1977 Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis. Tetradecanoylphorbol Acetate 54-91 ornithine decarboxylase, structural 1 Mus musculus 100-123 908030-3 1977 ODC was induced in both cell types by 12-O-tetradecanoyl-phorbol-13-acetate (TPA); maximal induction occurred 4 to 6 hr after the addition of the promoter to the medium of confluent cultures and was greater in transformed cells than in normal cells. Tetradecanoylphorbol Acetate 38-75 ornithine decarboxylase, structural 1 Mus musculus 0-3 908030-3 1977 ODC was induced in both cell types by 12-O-tetradecanoyl-phorbol-13-acetate (TPA); maximal induction occurred 4 to 6 hr after the addition of the promoter to the medium of confluent cultures and was greater in transformed cells than in normal cells. Tetradecanoylphorbol Acetate 77-80 ornithine decarboxylase, structural 1 Mus musculus 0-3 269443-6 1977 Paradoxially, FA potentiates the increase in ornithine decarboxylase activity after TPA administeration both in vivo and in vitro. Tetradecanoylphorbol Acetate 84-87 ornithine decarboxylase, structural 1 Mus musculus 45-68 191821-0 1977 Dissociation of increases in levels of 3":5"-cyclic AMP and 3":5"-cyclic GMP from induction of ornithine decarboxylase by the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate in mouse epidermis in vivo. Tetradecanoylphorbol Acetate 141-178 ornithine decarboxylase, structural 1 Mus musculus 95-118 191821-1 1977 A single application of 17 nmol of 12-O-tetradecanoyl phorbol-13-acetate (TPA) to mouse skin caused a marked (200- to 400-fold) induction of ornithine decarboxylase (EC 4.1.1.17, L-ornithine carboxy-lyase) activity in mouse epidermal and epidermal-dermal preparations. Tetradecanoylphorbol Acetate 35-72 ornithine decarboxylase, structural 1 Mus musculus 141-164 191821-1 1977 A single application of 17 nmol of 12-O-tetradecanoyl phorbol-13-acetate (TPA) to mouse skin caused a marked (200- to 400-fold) induction of ornithine decarboxylase (EC 4.1.1.17, L-ornithine carboxy-lyase) activity in mouse epidermal and epidermal-dermal preparations. Tetradecanoylphorbol Acetate 74-77 ornithine decarboxylase, structural 1 Mus musculus 141-164 191821-5 1977 When isoproterenol was injected 10 min prior to an application of either 1.7 or 17 nmol of TPA, the magnitude of the ornithine decarboxylase induction was the same as induction with TPA alone. Tetradecanoylphorbol Acetate 91-94 ornithine decarboxylase, structural 1 Mus musculus 117-140 954002-0 1976 The effect of colchicine on the induction of ornithine decarboxylase by 12-O-tetradecanoyl-phorbol-13-acetate. Tetradecanoylphorbol Acetate 72-109 ornithine decarboxylase, structural 1 Mus musculus 45-68 954002-1 1976 The induction of mouse epidermal ornithine decarboxylase, 1 of the earliest and largest phenotypic changes following treatment of mouse skin with the tumor-promoting agent, 12-O-tetradecanoyl-phorbol-13-acetate, can be inhibited by prior administration of colchicine. Tetradecanoylphorbol Acetate 173-210 ornithine decarboxylase, structural 1 Mus musculus 33-56 33310310-5 2021 RESULTS: The results provide evidence that topical treatment with HPSB significantly inhibits TPA-induced epidermal hyperplasia and leukocyte infiltration through the down-regulation of cyclooxygenase-2 (COX-2), matrix metalloprotein-9 (MMP-9), and ornithine decarboxylase (ODC) protein expression in mouse skin. Tetradecanoylphorbol Acetate 94-97 ornithine decarboxylase, structural 1 Mus musculus 249-272 33310310-5 2021 RESULTS: The results provide evidence that topical treatment with HPSB significantly inhibits TPA-induced epidermal hyperplasia and leukocyte infiltration through the down-regulation of cyclooxygenase-2 (COX-2), matrix metalloprotein-9 (MMP-9), and ornithine decarboxylase (ODC) protein expression in mouse skin. Tetradecanoylphorbol Acetate 94-97 ornithine decarboxylase, structural 1 Mus musculus 274-277