PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11342553-3	2001	Serum, lysophosphatidic acid, platelet-derived growth factor, and phorbol 12-myristate 13-acetate (PMA) each activated transcription of a stably integrated SRF reporter gene dependent on functional RhoA GTPase.	Tetradecanoylphorbol Acetate	66-97	serum response factor	Homo sapiens	156-159	
11342553-3	2001	Serum, lysophosphatidic acid, platelet-derived growth factor, and phorbol 12-myristate 13-acetate (PMA) each activated transcription of a stably integrated SRF reporter gene dependent on functional RhoA GTPase.	Tetradecanoylphorbol Acetate	99-102	serum response factor	Homo sapiens	156-159	
10777594-6	2000	Moreover, phorbol myristate acetate, a potent anti-apoptotic effector, was found to protect SRF completely from cleavage by caspase 3 and also to prevent the inhibition of the c-FOS promoter activity by death effectors.	Tetradecanoylphorbol Acetate	10-35	serum response factor	Homo sapiens	92-95	
9880563-6	1999	Serum response factor (SRF), Elk-1, and Sp1 bound to cognate sites within this segment, SRF and Elk-1 acting coordinately to affect both basal activity and TPA inducibility, whereas Sp1 affected basal activity only.	Tetradecanoylphorbol Acetate	156-159	serum response factor	Homo sapiens	0-21	
9880563-6	1999	Serum response factor (SRF), Elk-1, and Sp1 bound to cognate sites within this segment, SRF and Elk-1 acting coordinately to affect both basal activity and TPA inducibility, whereas Sp1 affected basal activity only.	Tetradecanoylphorbol Acetate	156-159	serum response factor	Homo sapiens	23-26	
9880563-6	1999	Serum response factor (SRF), Elk-1, and Sp1 bound to cognate sites within this segment, SRF and Elk-1 acting coordinately to affect both basal activity and TPA inducibility, whereas Sp1 affected basal activity only.	Tetradecanoylphorbol Acetate	156-159	serum response factor	Homo sapiens	88-91	
9880563-7	1999	Thus, the mechanism of the TPA-induced increase in MCL1 expression seen in myelomonocytic cells at early stages of differentiation involves signal transduction through ERKs and transcriptional activation through SRF/Elk-1.	Tetradecanoylphorbol Acetate	27-30	serum response factor	Homo sapiens	212-215	
8970984-7	1996	However, the TPA responsiveness of both CMV elements proved to involve synergistic interactions between the core SRF binding site (CCATATATGG) and the adjacent inverted ETS binding motifs (TTCC), which correlated directly with formation of a bound tripartite complex containing both the cellular SRF and ELK-1 proteins.	Tetradecanoylphorbol Acetate	13-16	serum response factor	Homo sapiens	113-116	
8970984-7	1996	However, the TPA responsiveness of both CMV elements proved to involve synergistic interactions between the core SRF binding site (CCATATATGG) and the adjacent inverted ETS binding motifs (TTCC), which correlated directly with formation of a bound tripartite complex containing both the cellular SRF and ELK-1 proteins.	Tetradecanoylphorbol Acetate	13-16	serum response factor	Homo sapiens	296-299	
30337297-5	2018	MRTFAOE increased binding of SRF to genomic sites and enhanced TPA-induced expression of SRF target genes.	Tetradecanoylphorbol Acetate	63-66	serum response factor	Homo sapiens	29-32	
30337297-5	2018	MRTFAOE increased binding of SRF to genomic sites and enhanced TPA-induced expression of SRF target genes.	Tetradecanoylphorbol Acetate	63-66	serum response factor	Homo sapiens	89-92	
30337297-6	2018	The TPA-induced genes are predicted to be regulated by SRF and ETS factors, whereas those upregulated by TPA plus MRTFAOE lack ETS binding motifs, and MRTFAOE skews SRF binding to genomic regions with CArG sites in regions relatively lacking in ETS binding motifs.	Tetradecanoylphorbol Acetate	4-7	serum response factor	Homo sapiens	55-58	
30337297-6	2018	The TPA-induced genes are predicted to be regulated by SRF and ETS factors, whereas those upregulated by TPA plus MRTFAOE lack ETS binding motifs, and MRTFAOE skews SRF binding to genomic regions with CArG sites in regions relatively lacking in ETS binding motifs.	Tetradecanoylphorbol Acetate	4-7	serum response factor	Homo sapiens	165-168	
7624133-9	1995	These results suggest that TRRS negatively regulates the transcriptional activation function of SRF, and consequently contributes to the low basal activity at the CArG box before TPA induction.	Tetradecanoylphorbol Acetate	179-182	serum response factor	Homo sapiens	96-99	
15806162-11	2005	RNAi-mediated knockdown of endogenous SRF, ELK1 and c-JUN protein expression significantly reduced TPA-stimulated FRA-1 promoter activity.	Tetradecanoylphorbol Acetate	99-102	serum response factor	Homo sapiens	38-41