PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15456774-9 2004 Furthermore, 7E4 abrogated LFA-1/ICAM-1 adhesion of phorbol 12-myristate 13-acetate-treated MOLT-4 cells. Tetradecanoylphorbol Acetate 52-83 integrin subunit alpha L Homo sapiens 27-32 16901728-6 2006 Notably, a high-affinity conformation of LFA-1 is mobile on resting cells but immobile on phorbol-12-myristate-13-acetate-activated cells. Tetradecanoylphorbol Acetate 90-121 integrin subunit alpha L Homo sapiens 41-46 30329215-3 2019 Phorbol 12-myristate 13-acetate activation of LFA-1 caused transient cytosolic domain separation. Tetradecanoylphorbol Acetate 0-31 integrin subunit alpha L Homo sapiens 46-51 22403260-4 2012 CD161(+)CD56(+)LFA-1(-) NK cells produce large amounts of CXCL8 after phorbol myristate acetate (PMA) or cytokine treatment. Tetradecanoylphorbol Acetate 70-95 integrin subunit alpha L Homo sapiens 15-20 22403260-4 2012 CD161(+)CD56(+)LFA-1(-) NK cells produce large amounts of CXCL8 after phorbol myristate acetate (PMA) or cytokine treatment. Tetradecanoylphorbol Acetate 97-100 integrin subunit alpha L Homo sapiens 15-20 10602019-8 1999 These results suggest that the T cell stimulation via anti-CD3 cross-linking or phorbol myristate acetate treatment up-regulates CD82 expression, leading to the colocalization of CD82 and LFA-1, and results in enhanced interaction between LFA-1 and ICAM-1. Tetradecanoylphorbol Acetate 80-105 integrin subunit alpha L Homo sapiens 188-193 10688643-2 2000 We found that the phorbol myristate acetate (PMA)-responsive protein kinase C (PKC) isotypes (alpha, betaI, betaII, and delta) or phosphatidylinositol-3-OH kinase (PI 3-kinase) itself activated LFA-1 to bind ICAM-1. Tetradecanoylphorbol Acetate 18-43 integrin subunit alpha L Homo sapiens 194-199 10688643-2 2000 We found that the phorbol myristate acetate (PMA)-responsive protein kinase C (PKC) isotypes (alpha, betaI, betaII, and delta) or phosphatidylinositol-3-OH kinase (PI 3-kinase) itself activated LFA-1 to bind ICAM-1. Tetradecanoylphorbol Acetate 45-48 integrin subunit alpha L Homo sapiens 194-199 12734401-2 2003 In this report, we investigated the mechanisms by which phorbol myristate acetate (PMA) promotes LFA-1-dependent cell adhesion. Tetradecanoylphorbol Acetate 56-81 integrin subunit alpha L Homo sapiens 97-102 12734401-2 2003 In this report, we investigated the mechanisms by which phorbol myristate acetate (PMA) promotes LFA-1-dependent cell adhesion. Tetradecanoylphorbol Acetate 83-86 integrin subunit alpha L Homo sapiens 97-102 10602019-8 1999 These results suggest that the T cell stimulation via anti-CD3 cross-linking or phorbol myristate acetate treatment up-regulates CD82 expression, leading to the colocalization of CD82 and LFA-1, and results in enhanced interaction between LFA-1 and ICAM-1. Tetradecanoylphorbol Acetate 80-105 integrin subunit alpha L Homo sapiens 239-244 8995416-6 1997 However, the interaction of TLN with LFA-1 on HL-60 cells was divalent cation-independent and phorbol 12-myristate 13-acetate stimulation-independent. Tetradecanoylphorbol Acetate 94-125 integrin subunit alpha L Homo sapiens 37-42 10529599-5 1999 RESULTS: Mean fluorescent intensity (MFI) of CR3 and LFA1-beta stimulated by PMA and ionomycin was significantly higher than that of the unstimulated control. Tetradecanoylphorbol Acetate 77-80 integrin subunit alpha L Homo sapiens 53-57 9160089-7 1997 Phorbol myristate acetate (PMA) induced a time- and dose-dependent up-regulation of CD11a, CD11b, CD11c, CD18 and CD54 that was inhibited by cycloheximide, suggesting a dependence on de novo protein synthesis. Tetradecanoylphorbol Acetate 0-25 integrin subunit alpha L Homo sapiens 84-89 9160089-7 1997 Phorbol myristate acetate (PMA) induced a time- and dose-dependent up-regulation of CD11a, CD11b, CD11c, CD18 and CD54 that was inhibited by cycloheximide, suggesting a dependence on de novo protein synthesis. Tetradecanoylphorbol Acetate 27-30 integrin subunit alpha L Homo sapiens 84-89 9247650-3 1997 We observed that LFA-1-expressing K562 cannot bind to intercellular adhesion molecule 1-coated surfaces when stimulated by phorbol 12-myristate 13-acetate (PMA), whereas the LFA-1-activating antibody KIM185 markedly enhanced adhesion. Tetradecanoylphorbol Acetate 156-159 integrin subunit alpha L Homo sapiens 17-22 10380899-5 1999 This indicates that accompanying activation of LFA-1, TPA induces the polyubiquitination of the membrane proteins, which are rapidly degraded by proteasomes. Tetradecanoylphorbol Acetate 54-57 integrin subunit alpha L Homo sapiens 47-52 9247650-3 1997 We observed that LFA-1-expressing K562 cannot bind to intercellular adhesion molecule 1-coated surfaces when stimulated by phorbol 12-myristate 13-acetate (PMA), whereas the LFA-1-activating antibody KIM185 markedly enhanced adhesion. Tetradecanoylphorbol Acetate 123-154 integrin subunit alpha L Homo sapiens 17-22 8948021-6 1996 Proper crosslinking of TCR together with CD4, CD8, or LFA-1 inhibits the death, and its inhibitory activity is mimicked by proper combinations of ionomycin, a calcium ionophore, and phorbol myristate acetate (PMA), a protein kinase C (PKC) activator. Tetradecanoylphorbol Acetate 182-207 integrin subunit alpha L Homo sapiens 54-59 9443649-4 1997 However, when phorbol myristate acetate (PMA)-activated T lymphocytes, which express lymphocyte function-associated antigen-1 (LFA-1), were cocultured with tumor cells, attachment of S20 increased twofold (60 +/- 11.9%) but AS6 showed no change (32 +/- 11%). Tetradecanoylphorbol Acetate 14-39 integrin subunit alpha L Homo sapiens 85-125 9443649-4 1997 However, when phorbol myristate acetate (PMA)-activated T lymphocytes, which express lymphocyte function-associated antigen-1 (LFA-1), were cocultured with tumor cells, attachment of S20 increased twofold (60 +/- 11.9%) but AS6 showed no change (32 +/- 11%). Tetradecanoylphorbol Acetate 14-39 integrin subunit alpha L Homo sapiens 127-132 9443649-4 1997 However, when phorbol myristate acetate (PMA)-activated T lymphocytes, which express lymphocyte function-associated antigen-1 (LFA-1), were cocultured with tumor cells, attachment of S20 increased twofold (60 +/- 11.9%) but AS6 showed no change (32 +/- 11%). Tetradecanoylphorbol Acetate 41-44 integrin subunit alpha L Homo sapiens 85-125 9443649-4 1997 However, when phorbol myristate acetate (PMA)-activated T lymphocytes, which express lymphocyte function-associated antigen-1 (LFA-1), were cocultured with tumor cells, attachment of S20 increased twofold (60 +/- 11.9%) but AS6 showed no change (32 +/- 11%). Tetradecanoylphorbol Acetate 41-44 integrin subunit alpha L Homo sapiens 127-132 7695161-2 1995 Treatment of leukocytes with phorbol myristate acetate (PMA) caused significant increases in the expression of adhesion molecules, CD11a, CD11b, CD11c, and CD18, on the surface of the leukocytes. Tetradecanoylphorbol Acetate 29-54 integrin subunit alpha L Homo sapiens 131-136 8896174-0 1996 A novel monoclonal antibody mNI-58A against the alpha-chain of leukocyte function-associated antigen-1 (LFA-1) blocks the homotypic cell aggregation and actively regulates morphological changes in the phorbol myristate acetate (PMA)-activated human monocyte-like cell line, U937. Tetradecanoylphorbol Acetate 201-226 integrin subunit alpha L Homo sapiens 63-102 8896174-0 1996 A novel monoclonal antibody mNI-58A against the alpha-chain of leukocyte function-associated antigen-1 (LFA-1) blocks the homotypic cell aggregation and actively regulates morphological changes in the phorbol myristate acetate (PMA)-activated human monocyte-like cell line, U937. Tetradecanoylphorbol Acetate 201-226 integrin subunit alpha L Homo sapiens 104-109 8896174-0 1996 A novel monoclonal antibody mNI-58A against the alpha-chain of leukocyte function-associated antigen-1 (LFA-1) blocks the homotypic cell aggregation and actively regulates morphological changes in the phorbol myristate acetate (PMA)-activated human monocyte-like cell line, U937. Tetradecanoylphorbol Acetate 228-231 integrin subunit alpha L Homo sapiens 63-102 8896174-0 1996 A novel monoclonal antibody mNI-58A against the alpha-chain of leukocyte function-associated antigen-1 (LFA-1) blocks the homotypic cell aggregation and actively regulates morphological changes in the phorbol myristate acetate (PMA)-activated human monocyte-like cell line, U937. Tetradecanoylphorbol Acetate 228-231 integrin subunit alpha L Homo sapiens 104-109 8621804-1 1996 Lymphocytes activate adhesion to intracellular adhesion mlecule 1 (ICAM-1) via leukocyte function associated antigen 1 (LFA-1), their major beta 2 integrin, in response to PMA (phorbol 12-myristate 13-acetate) without an increase in the number of receptors expressed. Tetradecanoylphorbol Acetate 172-175 integrin subunit alpha L Homo sapiens 79-118 8621804-1 1996 Lymphocytes activate adhesion to intracellular adhesion mlecule 1 (ICAM-1) via leukocyte function associated antigen 1 (LFA-1), their major beta 2 integrin, in response to PMA (phorbol 12-myristate 13-acetate) without an increase in the number of receptors expressed. Tetradecanoylphorbol Acetate 172-175 integrin subunit alpha L Homo sapiens 120-125 8621804-1 1996 Lymphocytes activate adhesion to intracellular adhesion mlecule 1 (ICAM-1) via leukocyte function associated antigen 1 (LFA-1), their major beta 2 integrin, in response to PMA (phorbol 12-myristate 13-acetate) without an increase in the number of receptors expressed. Tetradecanoylphorbol Acetate 177-208 integrin subunit alpha L Homo sapiens 79-118 8621804-1 1996 Lymphocytes activate adhesion to intracellular adhesion mlecule 1 (ICAM-1) via leukocyte function associated antigen 1 (LFA-1), their major beta 2 integrin, in response to PMA (phorbol 12-myristate 13-acetate) without an increase in the number of receptors expressed. Tetradecanoylphorbol Acetate 177-208 integrin subunit alpha L Homo sapiens 120-125 8631823-1 1996 The B-lymphoblastoid cell line JY undergoes homotypic aggregation in a lymphocyte function-associated antigen-1 (LFA-1)-mediated, intracellular adhesion molecule-1 (ICAM-1)-dependent manner when stimulated with phorbol 12-myristate 13-acetate or anti-LFA-1 antibodies. Tetradecanoylphorbol Acetate 211-242 integrin subunit alpha L Homo sapiens 71-111 8631823-1 1996 The B-lymphoblastoid cell line JY undergoes homotypic aggregation in a lymphocyte function-associated antigen-1 (LFA-1)-mediated, intracellular adhesion molecule-1 (ICAM-1)-dependent manner when stimulated with phorbol 12-myristate 13-acetate or anti-LFA-1 antibodies. Tetradecanoylphorbol Acetate 211-242 integrin subunit alpha L Homo sapiens 113-118 8631823-5 1996 p130cas phosphorylation was rapidly reversible upon disengagement of the LFA-1-ICAM-1 complex and required cell adhesion since binding of phorbol 12-myristate 13-acetate-stimulated JY cells to purified ICAM-1 or cross-linking of either LFA-1 or ICAM-1 was not sufficient to induce phosphorylation of p130cas. Tetradecanoylphorbol Acetate 138-169 integrin subunit alpha L Homo sapiens 73-78 8631823-5 1996 p130cas phosphorylation was rapidly reversible upon disengagement of the LFA-1-ICAM-1 complex and required cell adhesion since binding of phorbol 12-myristate 13-acetate-stimulated JY cells to purified ICAM-1 or cross-linking of either LFA-1 or ICAM-1 was not sufficient to induce phosphorylation of p130cas. Tetradecanoylphorbol Acetate 138-169 integrin subunit alpha L Homo sapiens 236-241 7695161-2 1995 Treatment of leukocytes with phorbol myristate acetate (PMA) caused significant increases in the expression of adhesion molecules, CD11a, CD11b, CD11c, and CD18, on the surface of the leukocytes. Tetradecanoylphorbol Acetate 56-59 integrin subunit alpha L Homo sapiens 131-136 7695161-8 1995 The monoclonal antibodies against CD11a, CD11b, CD18, and ICAM-1 also showed inhibitory effects on the increase in intracellular fluorescence intensity of the endothelial cells exposed to PMA-stimulated leukocytes. Tetradecanoylphorbol Acetate 188-191 integrin subunit alpha L Homo sapiens 34-39 7659180-2 1995 Staurosporine, a protein kinase inhibitor with broad profile of inhibitory activity on diverse protein kinases, but not CGP 41,251 substantially inhibited the TPA-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1, CD54) and to a lesser extent also its ligand CD11a. Tetradecanoylphorbol Acetate 159-162 integrin subunit alpha L Homo sapiens 276-281 8394087-3 1993 Detailed analysis of phorbol 12-myristate 13-acetate-treated THP-1 cells showed an increased PBR expression and the rise came along with an increase of CD11a and CD11b antigens and a secretion of macrophagic cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-8. Tetradecanoylphorbol Acetate 21-52 integrin subunit alpha L Homo sapiens 152-157 7916295-3 1994 We observed that phorbol 12-myristate 13-acetate, Mn2+, cross-linking of CD3 or activating antibodies against LFA-1 enhanced LFA-1-mediated T cell adhesion to ICAM-2 and -3, although to a lesser extent than to ICAM-1. Tetradecanoylphorbol Acetate 17-48 integrin subunit alpha L Homo sapiens 125-130 7906937-6 1994 The monoclonal antibodies against CD11a, CD11b, CD18, and ICAM-1 showed almost complete inhibition of the increase in intracellular peroxide levels of the endothelial cells exposed to PMA-stimulated leukocytes. Tetradecanoylphorbol Acetate 184-187 integrin subunit alpha L Homo sapiens 34-39 8255104-11 1993 Cells exposed to phorbol myristate acetate (PMA) had increased expression of CD11a, CD11b, CD18, CD45RO, and HLA-DR, whereas expression of CD15 and CD30 was markedly decreased. Tetradecanoylphorbol Acetate 17-42 integrin subunit alpha L Homo sapiens 77-82 8102559-15 1993 TPA-activated B-CLL cells showed a 1.2- to 13-fold increased expression of the adhesion molecules intercellular adhesion molecule-1 (ICAM-1), lymphocyte function-associated antigen (LFA)-1, and LFA-3, whereas expression of HLA class II molecules increased up to 5 times. Tetradecanoylphorbol Acetate 0-3 integrin subunit alpha L Homo sapiens 142-188 2450126-1 1988 In the present study a unique antibody (NKI-L16) reacting with the alpha-chain of the human leukocyte function-associated Ag-1 (LFA-1) is described, which stimulates homotypic cell-cell interactions in a manner very similar to 12-O-tetradecanoyl-phorbol-13-acetate (TPA), in contrast to other anti-LFA-1 mAb which inhibit cell aggregation. Tetradecanoylphorbol Acetate 227-264 integrin subunit alpha L Homo sapiens 92-126 2450126-1 1988 In the present study a unique antibody (NKI-L16) reacting with the alpha-chain of the human leukocyte function-associated Ag-1 (LFA-1) is described, which stimulates homotypic cell-cell interactions in a manner very similar to 12-O-tetradecanoyl-phorbol-13-acetate (TPA), in contrast to other anti-LFA-1 mAb which inhibit cell aggregation. Tetradecanoylphorbol Acetate 227-264 integrin subunit alpha L Homo sapiens 128-133 2450126-1 1988 In the present study a unique antibody (NKI-L16) reacting with the alpha-chain of the human leukocyte function-associated Ag-1 (LFA-1) is described, which stimulates homotypic cell-cell interactions in a manner very similar to 12-O-tetradecanoyl-phorbol-13-acetate (TPA), in contrast to other anti-LFA-1 mAb which inhibit cell aggregation. Tetradecanoylphorbol Acetate 266-269 integrin subunit alpha L Homo sapiens 92-126 2450126-1 1988 In the present study a unique antibody (NKI-L16) reacting with the alpha-chain of the human leukocyte function-associated Ag-1 (LFA-1) is described, which stimulates homotypic cell-cell interactions in a manner very similar to 12-O-tetradecanoyl-phorbol-13-acetate (TPA), in contrast to other anti-LFA-1 mAb which inhibit cell aggregation. Tetradecanoylphorbol Acetate 266-269 integrin subunit alpha L Homo sapiens 128-133 2450126-6 1988 It is hypothesized that NKI-L16 or TPA can cause the LFA-1 molecule to convert from an inactive to an active configuration, thereby permitting binding of LFA-1 to its natural ligand. Tetradecanoylphorbol Acetate 35-38 integrin subunit alpha L Homo sapiens 53-58 2450126-6 1988 It is hypothesized that NKI-L16 or TPA can cause the LFA-1 molecule to convert from an inactive to an active configuration, thereby permitting binding of LFA-1 to its natural ligand. Tetradecanoylphorbol Acetate 35-38 integrin subunit alpha L Homo sapiens 154-159 1459865-3 1992 Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) to link LFA-1 molecules to the cytoskeleton increased the percentage of capped cells, implying a faster and more efficient process of capping. Tetradecanoylphorbol Acetate 15-51 integrin subunit alpha L Homo sapiens 66-71 1459865-3 1992 Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) to link LFA-1 molecules to the cytoskeleton increased the percentage of capped cells, implying a faster and more efficient process of capping. Tetradecanoylphorbol Acetate 53-56 integrin subunit alpha L Homo sapiens 66-71 1355014-1 1992 The effects of several cytokines and phorbol myristate acetate (PMA) on LFA-1 and ICAM-1 expression on a human eosinophilic leukemia cell line, EoL-3, were investigated and compared with those of a human monocytic leukemia cell line, U937. Tetradecanoylphorbol Acetate 64-67 integrin subunit alpha L Homo sapiens 72-77 1566818-2 1992 The B lymphoblastoid line JY expresses both LFA-1 and ICAM-1, and intercellular adhesion is enhanced by treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA), which also induced capping of LFA-1, ICAM-1, and human leukocyte antigen. Tetradecanoylphorbol Acetate 137-168 integrin subunit alpha L Homo sapiens 44-49 1566818-2 1992 The B lymphoblastoid line JY expresses both LFA-1 and ICAM-1, and intercellular adhesion is enhanced by treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA), which also induced capping of LFA-1, ICAM-1, and human leukocyte antigen. Tetradecanoylphorbol Acetate 137-168 integrin subunit alpha L Homo sapiens 206-211 1566818-2 1992 The B lymphoblastoid line JY expresses both LFA-1 and ICAM-1, and intercellular adhesion is enhanced by treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA), which also induced capping of LFA-1, ICAM-1, and human leukocyte antigen. Tetradecanoylphorbol Acetate 170-173 integrin subunit alpha L Homo sapiens 44-49 1566818-2 1992 The B lymphoblastoid line JY expresses both LFA-1 and ICAM-1, and intercellular adhesion is enhanced by treatment with the phorbol ester phorbol 12-myristate 13-acetate (PMA), which also induced capping of LFA-1, ICAM-1, and human leukocyte antigen. Tetradecanoylphorbol Acetate 170-173 integrin subunit alpha L Homo sapiens 206-211 1371947-1 1992 The preferential growth of CD3-CD2-CD11a/CD18- thymocytes was obtained by stimulation of CD2-CD3- thymic cells with low doses of PMA (0.5 ng/ml) and subsequent culture in the presence of recombinant interleukin-2 (100 U/ml). Tetradecanoylphorbol Acetate 129-132 integrin subunit alpha L Homo sapiens 35-40 1715315-3 1991 In contrast, aggregate formation by B cells activated with phorbol myristate acetate (PMA) was only partially inhibited by anti-LFA-1 antibody, and those formed in response to PMA plus CD19 antibody were not inhibited at all, suggesting aggregation of activated B cells stimulated with CD19 antibody was LFA-1 independent. Tetradecanoylphorbol Acetate 59-84 integrin subunit alpha L Homo sapiens 128-133 1715315-3 1991 In contrast, aggregate formation by B cells activated with phorbol myristate acetate (PMA) was only partially inhibited by anti-LFA-1 antibody, and those formed in response to PMA plus CD19 antibody were not inhibited at all, suggesting aggregation of activated B cells stimulated with CD19 antibody was LFA-1 independent. Tetradecanoylphorbol Acetate 86-89 integrin subunit alpha L Homo sapiens 128-133 1975240-4 1990 Treatment of U-937 cells with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate in the presence of mAb to LFA-1 or ICAM-1 antigens yielded cells free from homotypic adhesions but differentiated as evidenced by their decreased proliferation and enhanced capacity for generation of superoxide anion. Tetradecanoylphorbol Acetate 48-84 integrin subunit alpha L Homo sapiens 111-116