PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31727941-7 2019 Following phorbol myristate acetate stimulation of the cultured PBMNCs, flow cytometry revealed a decrease in intracellular IL-10 storage in the main cell populations of the PBMNCs cultured from MMD patients relative to those cultured from controls. Tetradecanoylphorbol Acetate 10-35 interleukin 10 Homo sapiens 124-129 32447451-5 2020 RESULTS: Stimulation of cells by PMA or LPS (without Actovegin ) significantly increased the secretion of IL-1beta, IL-6, IL-10 and TNF-alpha from PBMCs, compared to controls. Tetradecanoylphorbol Acetate 33-36 interleukin 10 Homo sapiens 122-127 30707387-3 2019 After co-culture of UCB-MSCs and phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 cells using a transwell system, it showed that LPS significantly induced increases in the expression levels of interleukin 10 (IL-10), interleukin 37 (IL-37), phospho-PI3K (p-PI3K), and phospho-Akt (p-Akt) in macrophages. Tetradecanoylphorbol Acetate 33-64 interleukin 10 Homo sapiens 220-225 30707387-3 2019 After co-culture of UCB-MSCs and phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 cells using a transwell system, it showed that LPS significantly induced increases in the expression levels of interleukin 10 (IL-10), interleukin 37 (IL-37), phospho-PI3K (p-PI3K), and phospho-Akt (p-Akt) in macrophages. Tetradecanoylphorbol Acetate 66-69 interleukin 10 Homo sapiens 204-218 30707387-3 2019 After co-culture of UCB-MSCs and phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 cells using a transwell system, it showed that LPS significantly induced increases in the expression levels of interleukin 10 (IL-10), interleukin 37 (IL-37), phospho-PI3K (p-PI3K), and phospho-Akt (p-Akt) in macrophages. Tetradecanoylphorbol Acetate 66-69 interleukin 10 Homo sapiens 220-225 26836805-13 2016 The frequencies of B10 cells were similar in the three groups, irrespective of whether IL-10 was induced by a combination of phorbol 12-myristate 13-acetate (PMA) and ionomycin, by CpG oligodeoxynucletodies (ODN) 2006, or by TG. Tetradecanoylphorbol Acetate 158-161 interleukin 10 Homo sapiens 87-92 30415531-4 2019 In detail, pLTA decreased the production of IL-10 by phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells stimulated with prostaglandin E2 (PGE-2) and LPS. Tetradecanoylphorbol Acetate 53-84 interleukin 10 Homo sapiens 44-49 30415531-4 2019 In detail, pLTA decreased the production of IL-10 by phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells stimulated with prostaglandin E2 (PGE-2) and LPS. Tetradecanoylphorbol Acetate 86-89 interleukin 10 Homo sapiens 44-49 24801891-5 2014 Phorbol myristate acetate-stimulated whole blood interleukin (IL)-4, IL-5, IL-10, IL-12, IL-13, IL-17A, IL-17F, IL-22, and interferon-gamma secretory responses were analyzed for associations comparing participants with allergic vs nonallergic asthma phenotypes with those without asthma. Tetradecanoylphorbol Acetate 0-25 interleukin 10 Homo sapiens 75-80 25973018-12 2015 BCG induced HMGB1, IL-6, IL-10 and TNF-alpha production effectively in PMA-treated THP-1 cells. Tetradecanoylphorbol Acetate 71-74 interleukin 10 Homo sapiens 25-30 26016954-7 2015 To assess the maximal frequency of inducible IL-10+ B cells in the three donor groups PBMCs were stimulated with PMA/ionomycin. Tetradecanoylphorbol Acetate 113-116 interleukin 10 Homo sapiens 45-50 23169635-5 2012 In contrast, PC1(hi) cells produced more IL-10 than PC1(lo) cells when stimulated with LPS and phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 95-126 interleukin 10 Homo sapiens 41-46 23416458-8 2013 Furthermore the dose response curve for PMA/Ionomycin differed for IL-10 compared to IL-17 and IFN-gamma as it was biphasic with no IL-10 production at higher PMA/Ionomycin concentrations. Tetradecanoylphorbol Acetate 40-43 interleukin 10 Homo sapiens 67-72 23416458-8 2013 Furthermore the dose response curve for PMA/Ionomycin differed for IL-10 compared to IL-17 and IFN-gamma as it was biphasic with no IL-10 production at higher PMA/Ionomycin concentrations. Tetradecanoylphorbol Acetate 159-162 interleukin 10 Homo sapiens 67-72 23169635-5 2012 In contrast, PC1(hi) cells produced more IL-10 than PC1(lo) cells when stimulated with LPS and phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 128-131 interleukin 10 Homo sapiens 41-46 22192260-5 2011 In the presence of phorbol-12-myristate-13-acetate-ionomycin, with or without CAPE treatment, the asthmatic children showed significantly decreased levels of IL-10 secretion compared with the healthy controls. Tetradecanoylphorbol Acetate 19-50 interleukin 10 Homo sapiens 158-163 20889800-6 2011 We demonstrate that IL-10 can regulate this protective phenotype in phorbol myristate acetate (PMA)-treated THP-1 cells, monocyte-derived macrophages (MDMs), and human alveolar macrophages (AMs) infected with Mtb. Tetradecanoylphorbol Acetate 68-93 interleukin 10 Homo sapiens 20-25 20889800-6 2011 We demonstrate that IL-10 can regulate this protective phenotype in phorbol myristate acetate (PMA)-treated THP-1 cells, monocyte-derived macrophages (MDMs), and human alveolar macrophages (AMs) infected with Mtb. Tetradecanoylphorbol Acetate 95-98 interleukin 10 Homo sapiens 20-25 21646795-8 2011 Tr1 cells were defined as CD4+CD25+ T cells that predominantly produce IL-10 when costimulated with phorbol myristate acetate (PMA) and ionomycin. Tetradecanoylphorbol Acetate 100-125 interleukin 10 Homo sapiens 71-76 21646795-8 2011 Tr1 cells were defined as CD4+CD25+ T cells that predominantly produce IL-10 when costimulated with phorbol myristate acetate (PMA) and ionomycin. Tetradecanoylphorbol Acetate 127-130 interleukin 10 Homo sapiens 71-76 19740314-4 2009 This report confirms, using IL-32 small interfering RNA, that IL-32beta induces an anti-inflammatory cytokine IL-10 in K562-IL-32beta cells and U937 promonocytic cells, which express endogenous IL-32beta upon phorbol 12-myristate 13-acetate (PMA) treatment, and monocyte-derived dendritic cells (DC) upon lipopolysaccharide (LPS) treatment. Tetradecanoylphorbol Acetate 209-240 interleukin 10 Homo sapiens 110-115 19740314-4 2009 This report confirms, using IL-32 small interfering RNA, that IL-32beta induces an anti-inflammatory cytokine IL-10 in K562-IL-32beta cells and U937 promonocytic cells, which express endogenous IL-32beta upon phorbol 12-myristate 13-acetate (PMA) treatment, and monocyte-derived dendritic cells (DC) upon lipopolysaccharide (LPS) treatment. Tetradecanoylphorbol Acetate 242-245 interleukin 10 Homo sapiens 110-115 18023089-6 2007 Intracellular cytokine analysis for anti-inflammatory cytokine interleukin-10 (IL-10) was performed by in vitro stimulation with phorbol-myristate-acetate (PMA) and ionomycin. Tetradecanoylphorbol Acetate 129-154 interleukin 10 Homo sapiens 63-77 18684225-3 2008 Concanavalin A induced expression of IL-2 mRNA and production of IL-2, and the combination of thapsigargin and phorbol myristate acetate induced expression of IL-4 and IL-10 mRNAs and production of IL-4 and IL-10. Tetradecanoylphorbol Acetate 111-136 interleukin 10 Homo sapiens 168-173 18684225-3 2008 Concanavalin A induced expression of IL-2 mRNA and production of IL-2, and the combination of thapsigargin and phorbol myristate acetate induced expression of IL-4 and IL-10 mRNAs and production of IL-4 and IL-10. Tetradecanoylphorbol Acetate 111-136 interleukin 10 Homo sapiens 207-212 18692180-3 2008 Inhibition of PKC pathway, by chemical inhibitors or after PMA treatment, abolishes both IL-10 and TNF-alpha production. Tetradecanoylphorbol Acetate 59-62 interleukin 10 Homo sapiens 89-94 18023089-6 2007 Intracellular cytokine analysis for anti-inflammatory cytokine interleukin-10 (IL-10) was performed by in vitro stimulation with phorbol-myristate-acetate (PMA) and ionomycin. Tetradecanoylphorbol Acetate 129-154 interleukin 10 Homo sapiens 79-84 18023089-6 2007 Intracellular cytokine analysis for anti-inflammatory cytokine interleukin-10 (IL-10) was performed by in vitro stimulation with phorbol-myristate-acetate (PMA) and ionomycin. Tetradecanoylphorbol Acetate 156-159 interleukin 10 Homo sapiens 63-77 18023089-6 2007 Intracellular cytokine analysis for anti-inflammatory cytokine interleukin-10 (IL-10) was performed by in vitro stimulation with phorbol-myristate-acetate (PMA) and ionomycin. Tetradecanoylphorbol Acetate 156-159 interleukin 10 Homo sapiens 79-84 18023089-11 2007 Interestingly, approximately 4% of mucosal NKR(+) T cells expressing IL-10 were detected by in vitro stimulation with PMA and ionomycin. Tetradecanoylphorbol Acetate 118-121 interleukin 10 Homo sapiens 69-74 12938167-1 2003 We have investigated the effects of sex steroids, estradiol (E2), and testosterone (T) on the synthesis of tumor necrosis factor alpha (TNF-alpha) and interleukin-10 (IL-10) in phorbol-myristate-acetate (PMA)-differentiated human monoblastic U937 cells. Tetradecanoylphorbol Acetate 177-202 interleukin 10 Homo sapiens 151-165 15096183-8 2004 Cyclic-AMP augmented IL-10 production and cAMP response element binding protein activation upon stimulation by PMA/ionomycin. Tetradecanoylphorbol Acetate 111-114 interleukin 10 Homo sapiens 21-26 16265694-5 2005 Intracellular staining of interleukin 10 (IL-10) was performed after stimulation with PMA and ionomycin. Tetradecanoylphorbol Acetate 86-89 interleukin 10 Homo sapiens 26-40 16265694-5 2005 Intracellular staining of interleukin 10 (IL-10) was performed after stimulation with PMA and ionomycin. Tetradecanoylphorbol Acetate 86-89 interleukin 10 Homo sapiens 42-47 16265694-8 2005 PD-1-positive SS salivary lymphocytes expressed IL-10 intracellularly upon PMA/ionomycin stimulation. Tetradecanoylphorbol Acetate 75-78 interleukin 10 Homo sapiens 48-53 15582138-4 2004 Using intracellular staining and flow cytometry, we assessed the ability of freshly isolated liver T cells from these biopsies to produce IFN-gamma, TNF-alpha, IL-2, IL-4, and IL-10 in response to stimulation with PMA and ionomycin. Tetradecanoylphorbol Acetate 214-217 interleukin 10 Homo sapiens 176-181 15280448-3 2004 Our results demonstrate that IL-10 significantly inhibited MMP-2 transcription and protein expression induced by a phorbol ester, phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 130-161 interleukin 10 Homo sapiens 29-34 15010730-5 2004 RESULTS: A kinetic study in healthy controls showed that stimulation with phorbol 12-myristate 13-acetate and ionomycin significantly increased the frequencies of IL-10-producing CD3+, CD4+ and CD8+ cells. Tetradecanoylphorbol Acetate 74-105 interleukin 10 Homo sapiens 163-168 12938167-1 2003 We have investigated the effects of sex steroids, estradiol (E2), and testosterone (T) on the synthesis of tumor necrosis factor alpha (TNF-alpha) and interleukin-10 (IL-10) in phorbol-myristate-acetate (PMA)-differentiated human monoblastic U937 cells. Tetradecanoylphorbol Acetate 177-202 interleukin 10 Homo sapiens 167-172 11678905-4 2001 Following re-stimulation in vitro with PMA and ionomycin, CD4+ T cells produced IFNgamma, TNFalpha, TNFbeta, IL-2, IL-4, IL-10 and IL-13. Tetradecanoylphorbol Acetate 39-42 interleukin 10 Homo sapiens 121-126 14680506-9 2003 Interestingly, macrophages stimulated with phorbol 12-myristate 13-acetate/ionomycin displayed an augmented IL-10 response upon addition of dibutyryl cAMP, with corresponding downregulation in TNF-alpha, suggesting a complex interaction between protein kinase C and protein kinase A in cytokine regulation. Tetradecanoylphorbol Acetate 43-74 interleukin 10 Homo sapiens 108-113 11288761-7 2001 Addition of phorbol 12-myristate 13-acetate to the cultures rendered the cells resistant to dexamethasone with regard to proliferation and IL-10 and IFN-gamma production, but not to IL-2 and TNF-alpha production in both patients and controls. Tetradecanoylphorbol Acetate 12-43 interleukin 10 Homo sapiens 139-144 11493622-6 2001 LPS, zymosan, and PMA caused marked and dose-dependent increases in TNF-alpha and IL-10 production. Tetradecanoylphorbol Acetate 18-21 interleukin 10 Homo sapiens 82-87 10400827-8 1999 Addition of PKC inhibitors reverses the PMA-mediated down-regulation of LPS-induced IL-10 secretion, indicating that PKC, once activated in vivo, might play a prominent role in controlling the secretion of IL-10 by AM. Tetradecanoylphorbol Acetate 40-43 interleukin 10 Homo sapiens 84-89 11094104-4 2000 RESULTS: Pretreatment of T cells with IFN-beta potentiates the production of IL-10 when they interact with adult human microglia, human fetal microglia, or U937 cells treated with phorbol-12-myristate-13-acetate (PMA) and IFN-gamma. Tetradecanoylphorbol Acetate 180-211 interleukin 10 Homo sapiens 77-82 10400827-8 1999 Addition of PKC inhibitors reverses the PMA-mediated down-regulation of LPS-induced IL-10 secretion, indicating that PKC, once activated in vivo, might play a prominent role in controlling the secretion of IL-10 by AM. Tetradecanoylphorbol Acetate 40-43 interleukin 10 Homo sapiens 206-211 9815227-2 1998 Incubation with 20-100 ng/mL IL-10 for 2-3 days decreased the fungicidal activity of monocytes against serum-opsonized C. albicans blastoconidia (P</=.04), reduced their capacity to damage unopsonized hyphae (P</=.006), and suppressed superoxide anion production in response to phorbol myristate acetate (P=.019) and N-FMLP (P=.04) but not to serum-opsonized blastoconidia. Tetradecanoylphorbol Acetate 284-309 interleukin 10 Homo sapiens 29-34 10354374-6 1999 Phorbol 12-myristate 13-acetate stimulation revealed that, among lymphocytes, cord blood B cells are the main cellular source of interleukin-10. Tetradecanoylphorbol Acetate 0-31 interleukin 10 Homo sapiens 129-143 9758735-15 1998 In comparison, phorbol myristate acetate, a protein kinase C (PKC) activator, restored TNF and PCA production despite the presence of IL-10. Tetradecanoylphorbol Acetate 15-40 interleukin 10 Homo sapiens 134-139 9603471-4 1998 In contrast, the phorbol 12-myristate 13-acetate (PMA)-induced IL-10 production and CD69 expression, and the ionomycin plus PMA-induced IL-2 production are not affected. Tetradecanoylphorbol Acetate 17-48 interleukin 10 Homo sapiens 63-68 9603471-4 1998 In contrast, the phorbol 12-myristate 13-acetate (PMA)-induced IL-10 production and CD69 expression, and the ionomycin plus PMA-induced IL-2 production are not affected. Tetradecanoylphorbol Acetate 50-53 interleukin 10 Homo sapiens 63-68 8977524-7 1996 A23187, which synergizes with PMA in the induction of IL-4 and IFN-gamma, inhibited PMA-induced IL-10 production in a dose-dependent manner. Tetradecanoylphorbol Acetate 30-33 interleukin 10 Homo sapiens 96-101 9546811-5 1997 With the exception of one clone in the IL-2 group, all clones produced IL-10 on stimulation with anti-CD3 and phorbol-12-myristate 13-acetate (PMA) with similar mean values for both groups. Tetradecanoylphorbol Acetate 110-141 interleukin 10 Homo sapiens 71-76 9122616-6 1997 When IL-10 and IFN-gamma were added simultaneously to neutrophil culture, IL-10 dose-dependently reduced IFN-gamma-induced increase of CR3 expression, O(2)- production (in response to both FMLP and phorbol 12-myristate 13-acetate, or PMA) and ADCC, but did not change Fc gamma RI expression on phagocytes. Tetradecanoylphorbol Acetate 198-229 interleukin 10 Homo sapiens 5-10 9122616-6 1997 When IL-10 and IFN-gamma were added simultaneously to neutrophil culture, IL-10 dose-dependently reduced IFN-gamma-induced increase of CR3 expression, O(2)- production (in response to both FMLP and phorbol 12-myristate 13-acetate, or PMA) and ADCC, but did not change Fc gamma RI expression on phagocytes. Tetradecanoylphorbol Acetate 198-229 interleukin 10 Homo sapiens 74-79 8977524-7 1996 A23187, which synergizes with PMA in the induction of IL-4 and IFN-gamma, inhibited PMA-induced IL-10 production in a dose-dependent manner. Tetradecanoylphorbol Acetate 84-87 interleukin 10 Homo sapiens 96-101 8625537-9 1996 Similar but transient inhibition of most T-cell products (IL-2, IL-3, IL-4, IL-5, IL-10, TNF-beta and GM-CSF) was noted in the PMA/ionomycin-containing cultures. Tetradecanoylphorbol Acetate 127-130 interleukin 10 Homo sapiens 82-87 8865287-1 1996 The production of IL-10 by human neonatal blood mononuclear leukocytes (BML) stimulated with lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-alpha), antibodies to CD3, or phorbol 12-myristate 13-acetate (PMA) was measured. Tetradecanoylphorbol Acetate 182-213 interleukin 10 Homo sapiens 18-23 8865287-1 1996 The production of IL-10 by human neonatal blood mononuclear leukocytes (BML) stimulated with lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-alpha), antibodies to CD3, or phorbol 12-myristate 13-acetate (PMA) was measured. Tetradecanoylphorbol Acetate 215-218 interleukin 10 Homo sapiens 18-23 7912755-10 1994 Culture supernatants from blasts cultured with or without TPA showed the production of large amounts of IL-8, IL-6, TNF-alpha, MIP-1 alpha, IL-10 and interferon gamma and modest amounts of IL-1 alpha, GM-CSF and stem cell factor. Tetradecanoylphorbol Acetate 58-61 interleukin 10 Homo sapiens 140-145 8639843-4 1996 In highly purified CD4+ T cells, IFN-alpha upregulated IL-10 mRNA upon activation with phytohemagglutinin and phorbol myristate acetate. Tetradecanoylphorbol Acetate 110-135 interleukin 10 Homo sapiens 55-60 8550072-5 1995 With adult purified T cells, high levels of IL-10 and IL-4 were measured following CD3 plus CD28 stimulation, and the amounts of both T-helper type-2 (Th2) cytokines decreased following the addition of phorbol myristate acetate (PMA), whereas the synthesis of the Th1 cytokines IL-2 and IFN-gamma was enhanced. Tetradecanoylphorbol Acetate 202-227 interleukin 10 Homo sapiens 44-49 8565269-5 1996 Data showed a significantly higher production of IL-4 (P = 0.05) and IL-10 (P < 0.005) as determined by ELISA in phytohaemagglutinin (PHA)/phorbol myristate acetate (PMA)-stimulated mononuclear cells of atopic donors compared with controls, although spontaneous IL-4 production without stimulation was never detected within either atopic or control groups. Tetradecanoylphorbol Acetate 142-167 interleukin 10 Homo sapiens 69-74 7909823-6 1994 Primed cells are enriched in CD45R0hi and CD31- cells, and upon stimulation with PMA+ ionomycin they release significant amounts of IL-2, IFN-gamma, IL-4, IL-5, and IL-10. Tetradecanoylphorbol Acetate 81-84 interleukin 10 Homo sapiens 165-170 7905497-7 1994 In response to primary stimulation with PMA and ionomycin, cells primed with IL-4 + IL-2 produce IL-4, IL-5, and IL-10 and the same levels of IL-2 and IFN-gamma as IL-4-primed cells. Tetradecanoylphorbol Acetate 40-43 interleukin 10 Homo sapiens 113-118 8233727-11 1993 Considering the low proportion of lymphocytes, stimulation with phorbol myristate acetate in combination with ionomycin resulted in considerable production of the following lymphokines: IL-2, IL-3, IL-4, IL-10, interferon-gamma, tumor necrosis factor-alpha. Tetradecanoylphorbol Acetate 64-89 interleukin 10 Homo sapiens 204-209 1325212-7 1992 We demonstrated that EBV-positive cell lines derived from patients with American Burkitt"s lymphoma, and especially those from patients with AIDS, constitutively express large quantities of hIL-10 by Northern blot analysis and ELISA (range, 3,101 to 25,915 pg/mL), and that both teleocidin and PMA induce hIL-10 in these cell lines. Tetradecanoylphorbol Acetate 294-297 interleukin 10 Homo sapiens 190-196