PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11820799-2 2002 Immobilized TSP-1 enhanced IL-6 release from the human monocytic U937 cells stimulated with phorbol myristate acetate and LPS, whereas it inhibited IL-10 release. Tetradecanoylphorbol Acetate 92-117 thrombospondin 1 Homo sapiens 12-17 12225809-2 2002 In this study we found that exogenously added TSP-1 inhibits phorbol myristate acetate (PMA)/LPS-induced homotypic aggregation of human monocytic U937 cells, whereas the 70-kDa fragment of TSP-1 generated by the proteolytic cleavage of the intact molecule promotes the homotypic aggregation. Tetradecanoylphorbol Acetate 61-86 thrombospondin 1 Homo sapiens 46-51 12225809-2 2002 In this study we found that exogenously added TSP-1 inhibits phorbol myristate acetate (PMA)/LPS-induced homotypic aggregation of human monocytic U937 cells, whereas the 70-kDa fragment of TSP-1 generated by the proteolytic cleavage of the intact molecule promotes the homotypic aggregation. Tetradecanoylphorbol Acetate 88-91 thrombospondin 1 Homo sapiens 46-51 11642546-4 2001 In contrast, PMA showed just the opposite effects on the TSP-1 expression in the same cells. Tetradecanoylphorbol Acetate 13-16 thrombospondin 1 Homo sapiens 57-62 10067831-4 1999 On the contrary, the phorbol ester, 12-O-tetradecanoyl-phorbol 13-acetate (1-100 nM) prevented TSH-induced follicle formation and strongly increased the synthesis of TSP1. Tetradecanoylphorbol Acetate 36-73 thrombospondin 1 Homo sapiens 166-170 11216860-5 2001 Using two different cell lines, SK-HEP-1 and Hep 3B cells, we have studied effects of phorbol 12-myristate 13-acetate (PMA) on TSP-1 expression. Tetradecanoylphorbol Acetate 86-117 thrombospondin 1 Homo sapiens 127-132 11216860-5 2001 Using two different cell lines, SK-HEP-1 and Hep 3B cells, we have studied effects of phorbol 12-myristate 13-acetate (PMA) on TSP-1 expression. Tetradecanoylphorbol Acetate 119-122 thrombospondin 1 Homo sapiens 127-132 11216860-6 2001 TSP-1 synthesis was stimulated by PMA in both cell lines. Tetradecanoylphorbol Acetate 34-37 thrombospondin 1 Homo sapiens 0-5 11216860-7 2001 When the cells were treated with PMA, the TSP-1 mRNA started to increase at 30 min and reached the maximal level at 6 h. TSP-1 induction by PMA was completely inhibited by the pre-treatment of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a potent protein kinase C inhibitor. Tetradecanoylphorbol Acetate 33-36 thrombospondin 1 Homo sapiens 42-47 11216860-7 2001 When the cells were treated with PMA, the TSP-1 mRNA started to increase at 30 min and reached the maximal level at 6 h. TSP-1 induction by PMA was completely inhibited by the pre-treatment of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a potent protein kinase C inhibitor. Tetradecanoylphorbol Acetate 33-36 thrombospondin 1 Homo sapiens 121-126 11216860-7 2001 When the cells were treated with PMA, the TSP-1 mRNA started to increase at 30 min and reached the maximal level at 6 h. TSP-1 induction by PMA was completely inhibited by the pre-treatment of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a potent protein kinase C inhibitor. Tetradecanoylphorbol Acetate 140-143 thrombospondin 1 Homo sapiens 42-47 11216860-7 2001 When the cells were treated with PMA, the TSP-1 mRNA started to increase at 30 min and reached the maximal level at 6 h. TSP-1 induction by PMA was completely inhibited by the pre-treatment of 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7), a potent protein kinase C inhibitor. Tetradecanoylphorbol Acetate 140-143 thrombospondin 1 Homo sapiens 121-126 11048644-0 2000 Responsive site on the thrombospondin-1 promotor to down-regulation by phorbol 12-myristate 13-acetate in porcine aortic endothelial cells. Tetradecanoylphorbol Acetate 71-102 thrombospondin 1 Homo sapiens 23-39 11048644-2 2000 We found that the synthesis of TSP-1 in porcine aortic endothelial (PAE) cells was decreased in a dose-dependent manner by phorbol 12-myristate 13-acetate (PMA) treatment in porcine aortic endothelial (PAE) cells. Tetradecanoylphorbol Acetate 123-154 thrombospondin 1 Homo sapiens 31-36 11048644-2 2000 We found that the synthesis of TSP-1 in porcine aortic endothelial (PAE) cells was decreased in a dose-dependent manner by phorbol 12-myristate 13-acetate (PMA) treatment in porcine aortic endothelial (PAE) cells. Tetradecanoylphorbol Acetate 156-159 thrombospondin 1 Homo sapiens 31-36 10067831-6 1999 Transforming growth factor-beta, like 12-O-tetradecanoyl-phorbol 13-acetate, increased TSP1 synthesis and prevented TSH-induced follicle formation. Tetradecanoylphorbol Acetate 38-75 thrombospondin 1 Homo sapiens 87-91 7693024-4 1993 When the cells were cultured with 12-o-tetradecanoylphorbol-13-acetate (TPA), the expression of TSP was enhanced and vWF was also detected, but not Fbg. Tetradecanoylphorbol Acetate 72-75 thrombospondin 1 Homo sapiens 96-99 2942536-1 1986 Thrombospondin (TSP) is a multifunctional platelet alpha-granule and extracellular matrix glycoprotein that binds specifically to plasminogen (Plg) via that protein"s lysine-binding site and modulates activation by tissue activator (TPA). Tetradecanoylphorbol Acetate 233-236 thrombospondin 1 Homo sapiens 0-14 7693024-4 1993 When the cells were cultured with 12-o-tetradecanoylphorbol-13-acetate (TPA), the expression of TSP was enhanced and vWF was also detected, but not Fbg. Tetradecanoylphorbol Acetate 34-70 thrombospondin 1 Homo sapiens 96-99 1376114-4 1992 Newly expressed TSP receptors are not derived from easily mobilized specific granules since agents that trigger some specific granule release [phorbol myristate acetate (PMA), FMLP or ionophore A23187 alone] do not increase TSP receptor expression. Tetradecanoylphorbol Acetate 170-173 thrombospondin 1 Homo sapiens 16-19 2942536-1 1986 Thrombospondin (TSP) is a multifunctional platelet alpha-granule and extracellular matrix glycoprotein that binds specifically to plasminogen (Plg) via that protein"s lysine-binding site and modulates activation by tissue activator (TPA). Tetradecanoylphorbol Acetate 233-236 thrombospondin 1 Homo sapiens 16-19 2942536-2 1986 In this study we report that the plasminogen activators, TPA and urokinase, greatly influence the binding of Plg to TSP. Tetradecanoylphorbol Acetate 57-60 thrombospondin 1 Homo sapiens 116-119 19766325-8 2009 Patients with HAM/TSP had a higher p38/ERK ratio (p<0.05) associated with a reduced response to mitogens (phytohaemagglutinin or PMA+ionomycin) (p<0.001) and higher sensitivity to dexamethasone (p<0.05). Tetradecanoylphorbol Acetate 132-135 thrombospondin 1 Homo sapiens 18-21