PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3383343-0 1988 Distribution of catalase and its modulation by 12-O-tetradecanoylphorbol-13-acetate in murine dermis and subpopulations of keratinocytes differing in their stages of differentiation. Tetradecanoylphorbol Acetate 47-83 catalase Mus musculus 16-24 3383343-1 1988 Topical treatment of female SENCAR mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced both dermal and epidermal catalase-specific activities 38% and 51% within 6 h and 18 h of promoter application, respectively. Tetradecanoylphorbol Acetate 45-81 catalase Mus musculus 122-130 3383343-1 1988 Topical treatment of female SENCAR mice with 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced both dermal and epidermal catalase-specific activities 38% and 51% within 6 h and 18 h of promoter application, respectively. Tetradecanoylphorbol Acetate 83-86 catalase Mus musculus 122-130 3383343-5 1988 Pretreatment of the epidermis for 16-18 h with TPA (2 micrograms) uniformly reduced catalase-specific activity 46-52% in all keratinocyte subpopulations prepared by Percoll gradient centrifugation. Tetradecanoylphorbol Acetate 47-50 catalase Mus musculus 84-92 3383343-6 1988 Similarly, plots of catalase units per cell versus extracted protein per cell suggested 55-60% decreases in catalase activity in basal and spinous cell keratinocytes of TPA treated epidermis. Tetradecanoylphorbol Acetate 169-172 catalase Mus musculus 20-28 3383343-6 1988 Similarly, plots of catalase units per cell versus extracted protein per cell suggested 55-60% decreases in catalase activity in basal and spinous cell keratinocytes of TPA treated epidermis. Tetradecanoylphorbol Acetate 169-172 catalase Mus musculus 108-116 3383343-8 1988 Collectively, these studies suggest that: (i) TPA reduces the capacity for H2O2 detoxification by catalase throughout the epidermis; and (ii) activity measurements on unfractionated epidermal preparations may not be representative of the basal cell keratinocyte population. Tetradecanoylphorbol Acetate 46-49 catalase Mus musculus 98-106 31720442-4 2019 Topical application of DMBA+TPA increased oxidative stress as shown by significantly increased TBARS values and reduced glutathione contents, and glutathione-S-transferase, superoxide dismutase and catalase activities. Tetradecanoylphorbol Acetate 28-31 catalase Mus musculus 198-206 6488446-4 1984 Suppression of the TPA enhancement of transformation by catalase was a highly significant effect, while the suppression by SOD was not of statistical significance. Tetradecanoylphorbol Acetate 19-22 catalase Mus musculus 56-64 3948333-1 1986 After application of tetradecanoylphorbol acetate to mouse skin, a decrease in the specific activity of catalase in epidermal extracts has been observed, confirming the observation of earlier workers. Tetradecanoylphorbol Acetate 21-49 catalase Mus musculus 104-112 7318151-2 1981 The treatment of adult mouse skin with 2 micrograms 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a sustained decrease in the basal levels of both SOD and catalase activities in the epidermis. Tetradecanoylphorbol Acetate 52-88 catalase Mus musculus 164-172 7318151-2 1981 The treatment of adult mouse skin with 2 micrograms 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in a sustained decrease in the basal levels of both SOD and catalase activities in the epidermis. Tetradecanoylphorbol Acetate 90-93 catalase Mus musculus 164-172 7318151-4 1981 The alterations in both enzymes occurred against a high background of enhanced protein synthesis which indicates that the effect of TPA is selective for SOD and catalase. Tetradecanoylphorbol Acetate 132-135 catalase Mus musculus 153-169 7318151-7 1981 These results indicate that damage which favors neoplastic progression could occur in TPA-treated mouse skin due to the accumulation of free radicals resulting from low levels of SOD and catalase activity. Tetradecanoylphorbol Acetate 86-89 catalase Mus musculus 179-195 7318151-8 1981 In addition, the TPA-caused decrease in the levels of SOD and catalase was not prevented by either retinoic acid, fluocinolone acetonide, tosyl amino-2-phenylethyl chloromethyl ketone, or butylated hydroxytoluene, suggesting that inhibition of tumor promotion by these agents is not mediated through alterations in the levels of enzymatic activities which decrease free radical concentrations. Tetradecanoylphorbol Acetate 17-20 catalase Mus musculus 62-70 17674818-7 2007 TPA enhanced lipid peroxidation with reduction in the level of catalase, glutathione, glutathione peroxidase, glutathione reductase and glutathione-s-transferase. Tetradecanoylphorbol Acetate 0-3 catalase Mus musculus 63-71 21964610-7 2011 Histopathological findings of tumors found in PAT/TPA treated mice showed that these tumors were of squamous cell carcinoma type and similar to those found in the positive control group (DMBA/TPA) along with significant increase of lipid peroxidation and decrease in free sulfydryls, catalase, superoxide dismutase and glutathione reductase activities. Tetradecanoylphorbol Acetate 50-53 catalase Mus musculus 284-292 10357779-5 1999 Application of DMEP protected against the losses provoked in levels of glutathione and activity of catalase and superoxide dismutase in skin and liver of animals by the application of DMBA/TPA. Tetradecanoylphorbol Acetate 189-192 catalase Mus musculus 99-107 11134898-5 2001 Superoxide dismutase, catalase, and glutathione/glutathione peroxidase inhibited the PMA-induced increase in intracellular DCFH(2) oxidation. Tetradecanoylphorbol Acetate 85-88 catalase Mus musculus 22-30 8314805-2 1993 We report here that expression directed by a junB promoter/chloramphenicol acetyltransferase reporter construct (junB/CAT) is induced by fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), platelet-derived growth factor, and fibroblast growth factor in mouse fibroblast 3T6 cells. Tetradecanoylphorbol Acetate 157-193 catalase Mus musculus 118-121 21573453-5 1993 Induction of proliferin by the tumour promoters butylated hydroxytoluene or TPA was efficiently inhibited at certain concentrations of catalase and superoxide dismutase, but retinoic acid had no effect. Tetradecanoylphorbol Acetate 76-79 catalase Mus musculus 135-143 8314805-2 1993 We report here that expression directed by a junB promoter/chloramphenicol acetyltransferase reporter construct (junB/CAT) is induced by fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate (TPA), epidermal growth factor (EGF), platelet-derived growth factor, and fibroblast growth factor in mouse fibroblast 3T6 cells. Tetradecanoylphorbol Acetate 195-198 catalase Mus musculus 118-121 1747937-3 1991 Relative to solvent-treated controls, the specific activities of epidermal superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were reduced approximately 45, approximately 60 and approximately 24% respectively, 24 h after the fourth or tenth topical application of 1 microgram of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal skin of SENCAR mice. Tetradecanoylphorbol Acetate 304-340 catalase Mus musculus 103-111 1747937-3 1991 Relative to solvent-treated controls, the specific activities of epidermal superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were reduced approximately 45, approximately 60 and approximately 24% respectively, 24 h after the fourth or tenth topical application of 1 microgram of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal skin of SENCAR mice. Tetradecanoylphorbol Acetate 342-345 catalase Mus musculus 103-111 1747937-6 1991 CAT and SOD activities were also significantly suppressed in the skin adjacent to the papillomas for several weeks following the cessation of TPA promotion, but eventually recovered to the levels measured in age-matched controls. Tetradecanoylphorbol Acetate 142-145 catalase Mus musculus 0-3 2393871-5 1990 The ability of catalase, the enzyme that detoxifies hydrogen peroxide, to suppress DCFH oxidation to control levels suggested that intracellular hydrogen peroxide was responsible for the enhanced rate of DCFH oxidation in epidermal cells isolated from TPA-treated mice. Tetradecanoylphorbol Acetate 252-255 catalase Mus musculus 15-23 2347071-0 1990 Modulation of catalase activities in murine epidermal cells as a function of differentiation and exposure to 12-O-tetradecanoylphorbol-13-acetate. Tetradecanoylphorbol Acetate 109-145 catalase Mus musculus 14-22 2347071-3 1990 12-O-Tetradecanoylphorbol-13-acetate (TPA) treatment of proliferating MEKs cultured in low Ca2+ medium resulted in (i) an initial suppression of proliferation, (ii) the accelerated detachment and differentiation of detached MEKs and (iii) a suppression of catalase induction in the detached population. Tetradecanoylphorbol Acetate 0-36 catalase Mus musculus 256-264 2347071-3 1990 12-O-Tetradecanoylphorbol-13-acetate (TPA) treatment of proliferating MEKs cultured in low Ca2+ medium resulted in (i) an initial suppression of proliferation, (ii) the accelerated detachment and differentiation of detached MEKs and (iii) a suppression of catalase induction in the detached population. Tetradecanoylphorbol Acetate 38-41 catalase Mus musculus 256-264 2347071-9 1990 Catalase activity in the more differentiated MEKs was reduced approximately 33% within 24 h of topical treatment of dorsal skin with a promoting dose of TPA. Tetradecanoylphorbol Acetate 153-156 catalase Mus musculus 0-8 2347071-11 1990 Collectively, these studies demonstrate that per cell catalase activities increase as MEKs differentiate, and that TPA suppresses the increases in catalase activities that normally occur during differentiation. Tetradecanoylphorbol Acetate 115-118 catalase Mus musculus 147-155