PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12765200-10	2003	Resveratrol could inhibit PMA-induced IL-8 production in U937 cells at protein and mRNA levels.	Tetradecanoylphorbol Acetate	26-29	C-X-C motif chemokine ligand 8	Homo sapiens	38-42	
15081568-0	2004	The effect of TNF-alpha, PMA, and LPS on plasma and cell-associated IL-8 in human leukocytes.	Tetradecanoylphorbol Acetate	25-28	C-X-C motif chemokine ligand 8	Homo sapiens	68-72	
12812920-5	2003	However, zinc deficiency increased the levels of TNF-alpha, IL-1 beta, and IL-8 cytokines and mRNAs in HL-60 cells after 6 h of PMA stimulation compared with zinc-sufficient cells.	Tetradecanoylphorbol Acetate	128-131	C-X-C motif chemokine ligand 8	Homo sapiens	75-79	
12765200-7	2003	0.01-100 nM PMA could significantly induce IL-8 production in U937 cells; 10 microM Dexamethasone and 10, 1, 0.1 microM resveratrol could inhibit PMA-induced IL-8 protein production and mRNA accumulation.	Tetradecanoylphorbol Acetate	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	43-47	
12765200-7	2003	0.01-100 nM PMA could significantly induce IL-8 production in U937 cells; 10 microM Dexamethasone and 10, 1, 0.1 microM resveratrol could inhibit PMA-induced IL-8 protein production and mRNA accumulation.	Tetradecanoylphorbol Acetate	12-15	C-X-C motif chemokine ligand 8	Homo sapiens	158-162	
12765200-7	2003	0.01-100 nM PMA could significantly induce IL-8 production in U937 cells; 10 microM Dexamethasone and 10, 1, 0.1 microM resveratrol could inhibit PMA-induced IL-8 protein production and mRNA accumulation.	Tetradecanoylphorbol Acetate	146-149	C-X-C motif chemokine ligand 8	Homo sapiens	43-47	
12765200-7	2003	0.01-100 nM PMA could significantly induce IL-8 production in U937 cells; 10 microM Dexamethasone and 10, 1, 0.1 microM resveratrol could inhibit PMA-induced IL-8 protein production and mRNA accumulation.	Tetradecanoylphorbol Acetate	146-149	C-X-C motif chemokine ligand 8	Homo sapiens	158-162	
15037215-0	2004	Penta-O-galloyl-beta-D-glucose inhibits phorbol myristate acetate-induced interleukin-8 [correction of intereukin-8] gene expression in human monocytic U937 cells through its inactivation of nuclear factor-kappaB.	Tetradecanoylphorbol Acetate	40-65	C-X-C motif chemokine ligand 8	Homo sapiens	74-87	
15037215-2	2004	PGG inhibited IL-8 production and gene expression in human monocytic U937 cells stimulated with phorbol myristate acetate (PMA), as measured by enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction analysis, respectively.	Tetradecanoylphorbol Acetate	96-121	C-X-C motif chemokine ligand 8	Homo sapiens	14-18	
15037215-2	2004	PGG inhibited IL-8 production and gene expression in human monocytic U937 cells stimulated with phorbol myristate acetate (PMA), as measured by enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction analysis, respectively.	Tetradecanoylphorbol Acetate	123-126	C-X-C motif chemokine ligand 8	Homo sapiens	14-18	
14634065-3	2004	Although these are detectable even without stimulation, immunoglobulin (Ig)E receptor cross-linking is able to enhance only TNF-alpha production, but phorbol 12-myristate 13-acetate additionally promotes IL-1beta and IL-8.	Tetradecanoylphorbol Acetate	150-181	C-X-C motif chemokine ligand 8	Homo sapiens	217-221	
12499080-2	2003	MEM significantly inhibited PMA-induced secretions of IL-8 and MCP-1 proteins in a dose-dependent manner.	Tetradecanoylphorbol Acetate	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	54-58	
12499080-4	2003	In addition, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 proteins by its suppression of IL-8 and MCP-1 genes.	Tetradecanoylphorbol Acetate	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	136-140	
12499080-4	2003	In addition, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 proteins by its suppression of IL-8 and MCP-1 genes.	Tetradecanoylphorbol Acetate	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	182-186	
12452835-6	2002	In the A549 cells, gp-340 was up-regulated along with the PMA-induced proinflammatory expression of both IL-6 and IL-8.	Tetradecanoylphorbol Acetate	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	114-118	
11053033-3	2000	Triptolide, with an IC(50) of approximately 20-50 ng/ml, inhibits normal and transformed human bronchial epithelial cell expression of interleukin (IL)-6 and IL-8 stimulated by phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-alpha, or IL-1 beta.	Tetradecanoylphorbol Acetate	177-208	C-X-C motif chemokine ligand 8	Homo sapiens	158-162	
11562079-1	2001	We show that radicicol, an anti-fungal agent, inhibits interleukin-8 (IL-8) production by the human monocyte line THP-1 in response to phorbol-12-myristate-13-acetate/lipopolysaccharide (PMA/LPS).	Tetradecanoylphorbol Acetate	187-190	C-X-C motif chemokine ligand 8	Homo sapiens	70-74	
12683216-0	2002	Modulation of interleukin-8 receptor expression by lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) in human peripheral monocytes--a preliminary study.	Tetradecanoylphorbol Acetate	80-105	C-X-C motif chemokine ligand 8	Homo sapiens	14-27	
12683216-0	2002	Modulation of interleukin-8 receptor expression by lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) in human peripheral monocytes--a preliminary study.	Tetradecanoylphorbol Acetate	107-110	C-X-C motif chemokine ligand 8	Homo sapiens	14-27	
12683216-3	2002	We found that two very known modulators, lipopolysaccharide (LPS) in presence of homologous serum and Phorbol myristate acetate (PMA) resulted in induction of IL-8 receptor by 100-120% and 75-125% respectively within 1 h in monocytes.	Tetradecanoylphorbol Acetate	102-127	C-X-C motif chemokine ligand 8	Homo sapiens	159-163	
12683216-3	2002	We found that two very known modulators, lipopolysaccharide (LPS) in presence of homologous serum and Phorbol myristate acetate (PMA) resulted in induction of IL-8 receptor by 100-120% and 75-125% respectively within 1 h in monocytes.	Tetradecanoylphorbol Acetate	129-132	C-X-C motif chemokine ligand 8	Homo sapiens	159-163	
12683216-4	2002	Based on the inhibitory effect of cycloheximide, actinomycin-D we may suggest that PMA and LPS could upregulate IL-8 receptor in monocytes through denovo protein synthesis.	Tetradecanoylphorbol Acetate	83-86	C-X-C motif chemokine ligand 8	Homo sapiens	112-116	
12039947-7	2002	Inhibition of 12-O-tetradecanoyl-phorbol-13-acetate-stimulated IL-8 production by 1-butanol further strengthened this observation.	Tetradecanoylphorbol Acetate	14-51	C-X-C motif chemokine ligand 8	Homo sapiens	63-67	
12023021-4	2002	By prednisolone or phorbol myristate acetate treatment, EC-SOD levels were correlated negatively with levels of IL-6 and IL-8.	Tetradecanoylphorbol Acetate	19-44	C-X-C motif chemokine ligand 8	Homo sapiens	121-125	
11562079-1	2001	We show that radicicol, an anti-fungal agent, inhibits interleukin-8 (IL-8) production by the human monocyte line THP-1 in response to phorbol-12-myristate-13-acetate/lipopolysaccharide (PMA/LPS).	Tetradecanoylphorbol Acetate	135-166	C-X-C motif chemokine ligand 8	Homo sapiens	55-68	
11562079-1	2001	We show that radicicol, an anti-fungal agent, inhibits interleukin-8 (IL-8) production by the human monocyte line THP-1 in response to phorbol-12-myristate-13-acetate/lipopolysaccharide (PMA/LPS).	Tetradecanoylphorbol Acetate	135-166	C-X-C motif chemokine ligand 8	Homo sapiens	70-74	
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	45-74	C-X-C motif chemokine ligand 8	Homo sapiens	109-113	
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	45-74	C-X-C motif chemokine ligand 8	Homo sapiens	250-254	
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	109-113	
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	250-254	
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	172-175	C-X-C motif chemokine ligand 8	Homo sapiens	109-113	
10930303-5	2000	Stimulation with lipopolysaccharide (LPS) or tetradecanoyl phorbol acetate (TPA) significantly increased the IL-8 level secreted by all cell lines; the best producers were TPA-treated MONO-MAC-6 and MUTZ-3 cultures, generating more than 50 000 pg/ml IL-8.	Tetradecanoylphorbol Acetate	172-175	C-X-C motif chemokine ligand 8	Homo sapiens	250-254	
10357776-4	1999	Butyrate-induced expression of carcinoembryonic antigen and interleukin-8, dome formation and cell turnover were also markedly augmented by pre-treatment with phorbol myristate acetate.	Tetradecanoylphorbol Acetate	159-184	C-X-C motif chemokine ligand 8	Homo sapiens	60-73	
10887141-5	2000	Fibroblasts grown from synovial and peritoneal tissues displayed C5a/IL-8-inhibitor activity that could be further induced with phorbol myristate acetate (PMA) and IL-1 beta.	Tetradecanoylphorbol Acetate	128-153	C-X-C motif chemokine ligand 8	Homo sapiens	69-73	
10887141-5	2000	Fibroblasts grown from synovial and peritoneal tissues displayed C5a/IL-8-inhibitor activity that could be further induced with phorbol myristate acetate (PMA) and IL-1 beta.	Tetradecanoylphorbol Acetate	155-158	C-X-C motif chemokine ligand 8	Homo sapiens	69-73	
10833370-9	2000	Levels of IL-8 mRNA and protein were also dose-dependently increased by stimulation with IL-1beta, TNF-alpha and TPA.	Tetradecanoylphorbol Acetate	113-116	C-X-C motif chemokine ligand 8	Homo sapiens	10-14	
10683319-3	2000	Tetradecanoyl phorbol acetate (TPA) strongly increased the IL-8 and MCP-1 amounts in the culture supernatants of all five cell lines.	Tetradecanoylphorbol Acetate	0-29	C-X-C motif chemokine ligand 8	Homo sapiens	59-63	
10683319-3	2000	Tetradecanoyl phorbol acetate (TPA) strongly increased the IL-8 and MCP-1 amounts in the culture supernatants of all five cell lines.	Tetradecanoylphorbol Acetate	31-34	C-X-C motif chemokine ligand 8	Homo sapiens	59-63	
10464065-9	1999	The short-chain fatty acids, acetate, propionate, butyrate and valerate, the activator of protein kinase C (phorbol-12-myristate-13-acetate) and tumour necrosis factor-alpha (TNF-alpha) all stimulated the secretion of IL-8.	Tetradecanoylphorbol Acetate	108-139	C-X-C motif chemokine ligand 8	Homo sapiens	218-222	
10766857-3	2000	We report that IL-8 mRNA accumulation and protein secretion were down-regulated in IL-1beta- and lipopolysaccharide-stimulated differentiated HT-29 cells (HT-29/MTX, where MTX is methotrexate) compared with undifferentiated cells (HT-29/p), whereas no differential effects were found following tumor necrosis factor (TNF)-alpha or phorbol myristate acetate stimulation.	Tetradecanoylphorbol Acetate	331-356	C-X-C motif chemokine ligand 8	Homo sapiens	15-19	
10551153-10	1999	GM-CSF (50 IU/ml) also significantly increased IL-8 production from 2-7 days of treatment of THP-1 cells when supplemented with a positive control, phorbol-12-myristate-13 acetate (PMA), as compared to PMA treatment alone.	Tetradecanoylphorbol Acetate	148-179	C-X-C motif chemokine ligand 8	Homo sapiens	47-51	
9802987-5	1998	IL-8 was retained in these storage organelles for several days after the removal of the stimulus and could be released by EC secretagogues such as phorbol myristate acetate, the calcium ionophore A23187, and histamine.	Tetradecanoylphorbol Acetate	147-172	C-X-C motif chemokine ligand 8	Homo sapiens	0-4	
10051376-5	1999	Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner.	Tetradecanoylphorbol Acetate	89-92	C-X-C motif chemokine ligand 8	Homo sapiens	37-41	
9893038-7	1998	Phorbol 12-myristate 13-acetate pretreatment diminished the ability of BK to stimulate IL-8 production.	Tetradecanoylphorbol Acetate	0-31	C-X-C motif chemokine ligand 8	Homo sapiens	87-91	
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Tetradecanoylphorbol Acetate	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	175-179	
10191628-4	1999	Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha.	Tetradecanoylphorbol Acetate	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	248-252	
9809627-2	1998	Pretreatment of HL-60 or THP-1 cells with phorbol myristate acetate (PMA) enhanced their capacity to induce IL-8 production by T98G cells.	Tetradecanoylphorbol Acetate	42-67	C-X-C motif chemokine ligand 8	Homo sapiens	108-112	
9759900-8	1998	However, PGE2, forskolin, and PMA enhanced the stability of IL-8 mRNA transcripts, suggesting the involvement of posttranscriptional regulation.	Tetradecanoylphorbol Acetate	30-33	C-X-C motif chemokine ligand 8	Homo sapiens	60-64	
9809627-2	1998	Pretreatment of HL-60 or THP-1 cells with phorbol myristate acetate (PMA) enhanced their capacity to induce IL-8 production by T98G cells.	Tetradecanoylphorbol Acetate	69-72	C-X-C motif chemokine ligand 8	Homo sapiens	108-112	
8647994-4	1995	NHKs secreted detectable levels of IL-8, but not of IL-6, and IL-8 secretion increased over 20 fold by stimulation with 10 nM of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	129-160	C-X-C motif chemokine ligand 8	Homo sapiens	35-39	
9766632-5	1998	Despite their large disparity in potency, IL-8 and LPS printing were additive using fMLP, a receptor-dependent stimulator, and synergistic using the post-receptor, protein kinase C activator, phorbol 12-myristate 13-acetate (PMA) to trigger the respiratory burst.	Tetradecanoylphorbol Acetate	192-223	C-X-C motif chemokine ligand 8	Homo sapiens	42-46	
9766632-5	1998	Despite their large disparity in potency, IL-8 and LPS printing were additive using fMLP, a receptor-dependent stimulator, and synergistic using the post-receptor, protein kinase C activator, phorbol 12-myristate 13-acetate (PMA) to trigger the respiratory burst.	Tetradecanoylphorbol Acetate	225-228	C-X-C motif chemokine ligand 8	Homo sapiens	42-46	
9408252-7	1997	Production of both IL-6 and IL-8 was stimulated in a concentration-dependent fashion by interleukin-1beta (0.1-10 ng/ml), tumor necrosis factor-alpha (1-100 ng/ml), and bacterial lipopolysaccharide (0.1-10 microg/ml), and also by 100 nM phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	237-268	C-X-C motif chemokine ligand 8	Homo sapiens	28-32	
9136936-4	1997	Using an immunostaining method that enables simultaneous detection of cytokines and phenotype, 56 +/- 6% CD34+ peripheral blood progenitor cells (PBPC) were found to contain cytoplasmic IL-8 after stimulation with phorbol myristate acetate + ionomycin for 90 min.	Tetradecanoylphorbol Acetate	214-239	C-X-C motif chemokine ligand 8	Homo sapiens	186-190	
8712682-5	1996	TPA per se has no effect on [Ca2+]i, but potently reverses the NaF or ionomycin induced [Ca2+]i rise.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	63-66	
8712682-6	1996	Also, TPA partially counteracted the acidification induced by NaF.	Tetradecanoylphorbol Acetate	6-9	C-X-C motif chemokine ligand 8	Homo sapiens	62-65	
8712682-7	1996	Both NaF and ionomycin per se had no effect on cell growth but partially counteracted TPA induced growth inhibition.	Tetradecanoylphorbol Acetate	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	5-8	
8543831-6	1996	Treatment of TPA-stimulated Mono Mac6 cells resulted in a strong potentiation of secreted IL-1 bioactivity and expression of IL-1 alpha and IL-8 mRNA.	Tetradecanoylphorbol Acetate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	140-144	
9740146-10	1998	TPA (10 nmol/L) also stimulated the production of IL-6 and IL-8 by these cells, but inhibited that of monocyte chemoattractant protein-1.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	59-63	
9293391-7	1997	TPA-induced TNF-alpha and IL-8 release from keratinocytes.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	26-30	
9293391-9	1997	TPA increased RNA expression of the TNF-alpha, IL-1 alpha, IL-1 beta, IL-8 and TGF-beta 1.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	70-74	
9293391-10	1997	BC diminished TPA-induced TNF-alpha and IL-8 release from keratinocytes; in the case of IL-8 it is possible that this inhibition occur to transcriptional level.	Tetradecanoylphorbol Acetate	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	40-44	
9237814-6	1997	Activation of PKC by phorbol myristate acetate was also an effective stimulus to IL-8 production and this was blocked by PKC depletion or inhibitors.	Tetradecanoylphorbol Acetate	21-46	C-X-C motif chemokine ligand 8	Homo sapiens	81-85	
8647994-4	1995	NHKs secreted detectable levels of IL-8, but not of IL-6, and IL-8 secretion increased over 20 fold by stimulation with 10 nM of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	129-160	C-X-C motif chemokine ligand 8	Homo sapiens	62-66	
8647994-4	1995	NHKs secreted detectable levels of IL-8, but not of IL-6, and IL-8 secretion increased over 20 fold by stimulation with 10 nM of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	162-165	C-X-C motif chemokine ligand 8	Homo sapiens	35-39	
8647994-4	1995	NHKs secreted detectable levels of IL-8, but not of IL-6, and IL-8 secretion increased over 20 fold by stimulation with 10 nM of phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	162-165	C-X-C motif chemokine ligand 8	Homo sapiens	62-66	
7615975-4	1995	Transforming growth factor (TGF)-alpha, epidermal growth factor, and phorbol myristate acetate also enhanced the secretion of VPF/VEGF by keratinocytes; in contrast, a number of other cytokines including interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor-alpha, interferon-gamma, and transforming growth factor-beta did not induce VPF/VEGF secretion.	Tetradecanoylphorbol Acetate	69-94	C-X-C motif chemokine ligand 8	Homo sapiens	230-234	
7670094-4	1995	Calcitriol, 9 cis-RA, and sodium butyrate increase interleukin-8 (IL-8) mRNA expression, and pretreatment with these agents or RA potentiates the stimulation of IL-8 by phorbol ester (TPA).	Tetradecanoylphorbol Acetate	184-187	C-X-C motif chemokine ligand 8	Homo sapiens	161-165	
7559807-6	1995	Phosphorylation may not act directly on latent transcription factors, since bromophenacyl bromide, an inhibitor for the release of arachidonic acid from phorbol-12 myristate 13-acetate (PMA)-stimulated HL 60 cells, markedly depressed the induced mRNAs for IL-8, TNF-alpha, and IL-1 alpha and -beta.	Tetradecanoylphorbol Acetate	186-189	C-X-C motif chemokine ligand 8	Homo sapiens	256-260	
7875467-6	1995	Activation of PKC by phorbol myristate acetate also stimulated IL-8 production; however, the effects of IL-1 beta or TNF-alpha did not require PKC, as shown by the PKC inhibitor staurosporin or PKC depletion.	Tetradecanoylphorbol Acetate	21-46	C-X-C motif chemokine ligand 8	Homo sapiens	63-67	
7637390-1	1995	Interleukin-8 (IL-8) mRNA was rapidly, but not permanently, induced at high levels by phorbol-12myristate-13acetate (PMA) in HL60 cells.	Tetradecanoylphorbol Acetate	86-115	C-X-C motif chemokine ligand 8	Homo sapiens	0-13	
7637390-1	1995	Interleukin-8 (IL-8) mRNA was rapidly, but not permanently, induced at high levels by phorbol-12myristate-13acetate (PMA) in HL60 cells.	Tetradecanoylphorbol Acetate	86-115	C-X-C motif chemokine ligand 8	Homo sapiens	15-19	
7637390-1	1995	Interleukin-8 (IL-8) mRNA was rapidly, but not permanently, induced at high levels by phorbol-12myristate-13acetate (PMA) in HL60 cells.	Tetradecanoylphorbol Acetate	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	0-13	
7637390-1	1995	Interleukin-8 (IL-8) mRNA was rapidly, but not permanently, induced at high levels by phorbol-12myristate-13acetate (PMA) in HL60 cells.	Tetradecanoylphorbol Acetate	117-120	C-X-C motif chemokine ligand 8	Homo sapiens	15-19	
7759889-6	1995	More than 35% of the cell-associated IL-8 could be released by stimulation with either Ca2+ ionophore A23187 or phorbol myristate acetate.	Tetradecanoylphorbol Acetate	112-137	C-X-C motif chemokine ligand 8	Homo sapiens	37-41	
7517209-6	1994	In addition, supernatants of purified B-CLL cells cultured in the presence of 12-O-tetradecanoylphorbol-13-acetate showed chemotactic activity towards neutrophils; this activity was neutralized in the presence of an anti-IL-8 antiserum.	Tetradecanoylphorbol Acetate	78-114	C-X-C motif chemokine ligand 8	Homo sapiens	221-225	
7930675-6	1994	Auranofin and staurosporine, inhibitors of protein kinase C, inhibited phorbol-myristate-acetate-stimulated IL-8 production.	Tetradecanoylphorbol Acetate	71-96	C-X-C motif chemokine ligand 8	Homo sapiens	108-112	
8034626-6	1994	No effects of the Rap1A mutants on cell viability, proliferation, expression of cell-surface markers, or phorbol 12-myristate 13-acetate-stimulated interleukin-8 generation were detected.	Tetradecanoylphorbol Acetate	105-136	C-X-C motif chemokine ligand 8	Homo sapiens	148-161	
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Tetradecanoylphorbol Acetate	151-182	C-X-C motif chemokine ligand 8	Homo sapiens	79-92	
8195701-5	1994	Under these conditions interleukin-8 (IL-8) production was attenuated (by 50-90%) in response to lipopolysaccharide, granulocyte-macrophage colony-stimulating factor, and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	171-196	C-X-C motif chemokine ligand 8	Homo sapiens	23-36	
8195701-5	1994	Under these conditions interleukin-8 (IL-8) production was attenuated (by 50-90%) in response to lipopolysaccharide, granulocyte-macrophage colony-stimulating factor, and phorbol myristate acetate.	Tetradecanoylphorbol Acetate	171-196	C-X-C motif chemokine ligand 8	Homo sapiens	38-42	
7912755-10	1994	Culture supernatants from blasts cultured with or without TPA showed the production of large amounts of IL-8, IL-6, TNF-alpha, MIP-1 alpha, IL-10 and interferon gamma and modest amounts of IL-1 alpha, GM-CSF and stem cell factor.	Tetradecanoylphorbol Acetate	58-61	C-X-C motif chemokine ligand 8	Homo sapiens	104-108	
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Tetradecanoylphorbol Acetate	151-182	C-X-C motif chemokine ligand 8	Homo sapiens	94-98	
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Tetradecanoylphorbol Acetate	184-187	C-X-C motif chemokine ligand 8	Homo sapiens	79-92	
7510691-2	1994	We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).	Tetradecanoylphorbol Acetate	184-187	C-X-C motif chemokine ligand 8	Homo sapiens	94-98	
8413306-1	1993	The interleukin-8 promoter is transcriptionally activated by interleukin-1, tumor necrosis factor alpha, phorbol myristate acetate, or hepatitis B virus X protein through a sequence located between positions -91 and -71.	Tetradecanoylphorbol Acetate	105-130	C-X-C motif chemokine ligand 8	Homo sapiens	4-17	
8193081-10	1994	Stimulation of NHKs with phorbol 12-myristate 13-acetate(PMA) and lipopolysaccharide(LPS) resulted in an increase of IL-8 and decrease of IL-1 alpha in the culture supernatants.	Tetradecanoylphorbol Acetate	25-56	C-X-C motif chemokine ligand 8	Homo sapiens	117-121	
8193081-10	1994	Stimulation of NHKs with phorbol 12-myristate 13-acetate(PMA) and lipopolysaccharide(LPS) resulted in an increase of IL-8 and decrease of IL-1 alpha in the culture supernatants.	Tetradecanoylphorbol Acetate	57-60	C-X-C motif chemokine ligand 8	Homo sapiens	117-121	
8193081-12	1994	Hydrocortisone and cyclosporin A showed similar inhibitory effects on PMA/LPS-increased IL-8 secretion from NHKs but had little effect of restoring IL-1 alpha.	Tetradecanoylphorbol Acetate	70-73	C-X-C motif chemokine ligand 8	Homo sapiens	88-92	
8202627-1	1994	In human fibroblast cultures TPA increased IL-6 and IL-8 production.	Tetradecanoylphorbol Acetate	29-32	C-X-C motif chemokine ligand 8	Homo sapiens	52-56	
8281849-6	1994	At the cellular level, 5-aminosalicylic acid inhibited phorbol myristate acetate (100 ng/ml)-activated superoxide generation to 82.3 +/- 9.3%, the formylmethionyl leucyl peptide (10(-5) M) to 61.0 +/- 6.8%, and the NaF (20 mM)-stimulated production to 32.3 +/- 3.2% (mean +/- SD, P < 0.01).	Tetradecanoylphorbol Acetate	55-80	C-X-C motif chemokine ligand 8	Homo sapiens	215-218	
8267589-6	1993	Activators of protein kinase C, phorbol myristate acetate (PMA) and 1-oleyl-2-acetyl-sn-glycerol (OAG), inhibited cytosolic Ca(2+)-increase completely when induced by IL-8 and by 68-82% in the case of fMLP.	Tetradecanoylphorbol Acetate	32-57	C-X-C motif chemokine ligand 8	Homo sapiens	167-171	
8267589-6	1993	Activators of protein kinase C, phorbol myristate acetate (PMA) and 1-oleyl-2-acetyl-sn-glycerol (OAG), inhibited cytosolic Ca(2+)-increase completely when induced by IL-8 and by 68-82% in the case of fMLP.	Tetradecanoylphorbol Acetate	59-62	C-X-C motif chemokine ligand 8	Homo sapiens	167-171	
7515597-5	1994	This method was applied to cloning of a cDNA encoding interleukin 8 (IL-8) from a cDNA library prepared from phorbol myristate acetate-treated U937 cells.	Tetradecanoylphorbol Acetate	109-134	C-X-C motif chemokine ligand 8	Homo sapiens	54-67	
7515597-5	1994	This method was applied to cloning of a cDNA encoding interleukin 8 (IL-8) from a cDNA library prepared from phorbol myristate acetate-treated U937 cells.	Tetradecanoylphorbol Acetate	109-134	C-X-C motif chemokine ligand 8	Homo sapiens	69-73	
8413215-4	1993	A nuclear complex was induced in phorbol myristate acetate-treated Jurkat T cells which bound specifically to the kappa B site of the IL-8 promoter and was inhibited by addition of purified I kappa B alpha to the reaction mixture.	Tetradecanoylphorbol Acetate	33-58	C-X-C motif chemokine ligand 8	Homo sapiens	134-138	
8413215-10	1993	Antisense oligonucleotides to RelA, but not NFKB1, inhibited phorbol myristate acetate-induced IL-8 production in Jurkat T lymphocytes.	Tetradecanoylphorbol Acetate	61-86	C-X-C motif chemokine ligand 8	Homo sapiens	95-99	
8396851-5	1993	RESULTS: Significant quantities of interleukin-8 were produced by the tissue, and the data indicate that cervical explants from pregnant and nonpregnant women behave in a similar way when challenged by phorbol myristate acetate but that the postmenopausal cervix loses its capacity for interleukin-8 production.	Tetradecanoylphorbol Acetate	202-227	C-X-C motif chemokine ligand 8	Homo sapiens	35-48	
8245177-1	1993	In human monocytes phorbol-12-myristate 13-acetate (PMA) did not induce IL-6 but it increased IL-1 beta and IL-8 mRNA levels.	Tetradecanoylphorbol Acetate	19-50	C-X-C motif chemokine ligand 8	Homo sapiens	108-112	
8245177-1	1993	In human monocytes phorbol-12-myristate 13-acetate (PMA) did not induce IL-6 but it increased IL-1 beta and IL-8 mRNA levels.	Tetradecanoylphorbol Acetate	52-55	C-X-C motif chemokine ligand 8	Homo sapiens	108-112	
8360592-5	1993	While phorbol myristate acetate-induced IL-1 beta and IL-8 mRNA expression was increased by RA (IL-6 could not be induced by this pathway in monocytes), IL-1 beta-induced expression of IL-1 beta and IL-8 was markedly reduced and IL-6 gene expression was almost completely suppressed.	Tetradecanoylphorbol Acetate	6-31	C-X-C motif chemokine ligand 8	Homo sapiens	54-58	
8394087-3	1993	Detailed analysis of phorbol 12-myristate 13-acetate-treated THP-1 cells showed an increased PBR expression and the rise came along with an increase of CD11a and CD11b antigens and a secretion of macrophagic cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-8.	Tetradecanoylphorbol Acetate	21-52	C-X-C motif chemokine ligand 8	Homo sapiens	287-291	
8273591-1	1993	Several protein kinase inhibitors (PKIs) were investigated for their effects on IL-1 beta, TNF alpha and PMA-induced IL-8 production from human umbilical vein endothelial cells (HUVEC).	Tetradecanoylphorbol Acetate	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	117-121	
8319811-3	1993	Bacterial lipopolysaccharide endotoxin (LPS) or phorbol myristate acetate (PMA) alone induced suboptimal expression as assessed by Northern blotting; however, preincubation of cells with PMA followed by endotoxin induced much higher levels of IL-8 mRNA.	Tetradecanoylphorbol Acetate	48-73	C-X-C motif chemokine ligand 8	Homo sapiens	243-247	
8319811-3	1993	Bacterial lipopolysaccharide endotoxin (LPS) or phorbol myristate acetate (PMA) alone induced suboptimal expression as assessed by Northern blotting; however, preincubation of cells with PMA followed by endotoxin induced much higher levels of IL-8 mRNA.	Tetradecanoylphorbol Acetate	75-78	C-X-C motif chemokine ligand 8	Homo sapiens	243-247	
8319811-3	1993	Bacterial lipopolysaccharide endotoxin (LPS) or phorbol myristate acetate (PMA) alone induced suboptimal expression as assessed by Northern blotting; however, preincubation of cells with PMA followed by endotoxin induced much higher levels of IL-8 mRNA.	Tetradecanoylphorbol Acetate	187-190	C-X-C motif chemokine ligand 8	Homo sapiens	243-247	
8443122-1	1993	Few known genes (IL-2, members of the IL-8 family, interferon-gamma) are induced in T cells only through the combined effect of phorbol myristic acetate (PMA) and a Ca(2+)-ionophore, and expression of only these genes can be fully suppressed by Cyclosporin A (CyA).	Tetradecanoylphorbol Acetate	154-157	C-X-C motif chemokine ligand 8	Homo sapiens	38-42	
1827816-6	1991	In addition, immunoprecipitation analysis of PMA/ionomycin-treated T cell lysates detected only minor levels of cellular IL-8 Ag thereby suggesting that in T cells, the production of IL-8 was inhibited at the posttranscriptional level.	Tetradecanoylphorbol Acetate	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	183-187	
1398515-5	1992	Supernatants of TPA-stimulated Co cells contained the cytokines IL2, IL3, IL4 and IL8, whereas these cytokines were not detected in the supernatants of untreated cells.	Tetradecanoylphorbol Acetate	16-19	C-X-C motif chemokine ligand 8	Homo sapiens	82-85	
1540395-2	1992	Phorbol 12-myristate 13-acetate (PMA), alpha-thrombin, and sodium fluoride (NaF), a direct G-protein activator, produced a rapid and time-dependent translocation of PKC from the cytosol to the membrane.	Tetradecanoylphorbol Acetate	0-31	C-X-C motif chemokine ligand 8	Homo sapiens	76-79	
1540395-3	1992	Activation of PKC by brief pretreatment of human umbilical vein endothelial cell (HUVEC) monolayers with PMA resulted in the inhibition of NaF-induced inositol phosphate increases and attenuation of both alpha-thrombin- and NaF-activated increases in intracellular Ca2+ (Ca2+i).	Tetradecanoylphorbol Acetate	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	139-142	
1540395-3	1992	Activation of PKC by brief pretreatment of human umbilical vein endothelial cell (HUVEC) monolayers with PMA resulted in the inhibition of NaF-induced inositol phosphate increases and attenuation of both alpha-thrombin- and NaF-activated increases in intracellular Ca2+ (Ca2+i).	Tetradecanoylphorbol Acetate	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	224-227	
1856209-2	1991	The production of IL-8 is usually not constitutive and can be induced rapidly and abundantly in different cell types by a variety of stimuli such as lipopolysaccharide, interleukin-1, tumor necrosis factor-alpha as well as a tumor promotor phorbol myristate acetate.	Tetradecanoylphorbol Acetate	240-265	C-X-C motif chemokine ligand 8	Homo sapiens	18-22	
2824608-1	1987	A novel monocyte-derived neutrophil-activating peptide (MONAP) produced by lipopolysaccharide- and phorbol myristate acetate-stimulated human peripheral blood monocytes was purified by sequential ion exchange-high performance liquid chromatography (HPLC), size exclusion HPLC, and reversed phase HPLC.	Tetradecanoylphorbol Acetate	99-124	C-X-C motif chemokine ligand 8	Homo sapiens	8-54	
2168414-4	1990	Furthermore, when thrombin (0.1 unit/ml) or the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) had raised pHi from 7.13 +/- 0.05 to 7.35 +/- 0.07 (n = 30), addition of NaF (2.5-10 mM) rapidly restored pHi to values found before stimulation.	Tetradecanoylphorbol Acetate	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	178-181	
2168414-5	1990	Conversely, preincubation of platelets with low concentrations of NaF (2.5 mM) completely prevented alkalinization in response to thrombin or TPA.	Tetradecanoylphorbol Acetate	142-145	C-X-C motif chemokine ligand 8	Homo sapiens	66-69	
34572313-12	2021	In conclusion, we discovered that cross-talk between FcgammaRIII engagement-induced Syk-ERK and PMA-induced PKC signaling pathways augment NET formation of dHL-60 via increased ROS generation and pro-inflammatory cytokines, IL-8 and TNF-alpha, production.	Tetradecanoylphorbol Acetate	96-99	C-X-C motif chemokine ligand 8	Homo sapiens	224-228	
2510716-4	1989	After a 10 s pre-treatment with PMA (16 nM), dense-granule secretion induced by thrombin (0.2 unit/ml), GTP[S] (40 microM) and NaF (30 mM) was potentiated, resulting in a greater than additive response to agent plus PMA.	Tetradecanoylphorbol Acetate	32-35	C-X-C motif chemokine ligand 8	Homo sapiens	127-130	
2510716-4	1989	After a 10 s pre-treatment with PMA (16 nM), dense-granule secretion induced by thrombin (0.2 unit/ml), GTP[S] (40 microM) and NaF (30 mM) was potentiated, resulting in a greater than additive response to agent plus PMA.	Tetradecanoylphorbol Acetate	216-219	C-X-C motif chemokine ligand 8	Homo sapiens	127-130	
2510716-7	1989	That secretion induced by these agents is a protein kinase C-dependent event was demonstrable by using staurosporine, a protein kinase C inhibitor which at concentrations of 1-10 nM inhibited (70-90%) PMA-induced as well as thrombin- and NaF-induced secretion and protein phosphorylation.	Tetradecanoylphorbol Acetate	201-204	C-X-C motif chemokine ligand 8	Homo sapiens	238-241	
2824608-1	1987	A novel monocyte-derived neutrophil-activating peptide (MONAP) produced by lipopolysaccharide- and phorbol myristate acetate-stimulated human peripheral blood monocytes was purified by sequential ion exchange-high performance liquid chromatography (HPLC), size exclusion HPLC, and reversed phase HPLC.	Tetradecanoylphorbol Acetate	99-124	C-X-C motif chemokine ligand 8	Homo sapiens	56-61	
6373000-4	1984	Furthermore, the nonspecific esterase activity of TPA-treated cells and weak activity in 10% of untreated cells was strongly inhibited by NaF, a characteristic of monocytic series of cells.	Tetradecanoylphorbol Acetate	50-53	C-X-C motif chemokine ligand 8	Homo sapiens	138-141	
3085668-4	1986	Pretreatment of the platelets with the selective protein kinase C inhibitor H7 prevents TPA induced inhibition of NaF mediated rise in [Ca++]i and TxB2 generation.	Tetradecanoylphorbol Acetate	88-91	C-X-C motif chemokine ligand 8	Homo sapiens	114-117	
2985653-9	1985	Preincubation of neutrophils with NAF resulted in greater release of superoxide anion upon their subsequent stimulation by either bacterial phagocytosis or by phorbol myristate acetate, as compared with control neutrophils stimulated in a like manner.	Tetradecanoylphorbol Acetate	159-184	C-X-C motif chemokine ligand 8	Homo sapiens	34-37	
30323026-5	2019	Suppression of IL-8 in human embryonic kidney (HEK293) cells that were transformed to express TLR5 was observed not only upon inflammatory stimulation by flagellin but also in response to tumor necrosis factor alpha (TNF-alpha) and phorbol myristate acetate (PMA), despite the fact that the TNF-alpha- and PMA-induced inflammatory pathways reportedly are not TLR5 mediated.	Tetradecanoylphorbol Acetate	232-257	C-X-C motif chemokine ligand 8	Homo sapiens	15-19	
31893611-0	2020	Methyl linderone suppresses TPA-stimulated IL-8 and MMP-9 expression via the ERK/STAT3 pathway in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	28-31	C-X-C motif chemokine ligand 8	Homo sapiens	43-47	
31893611-6	2020	Moreover, it inhibited two metastasis-related factors, matrix metalloproteinase-9 (MMP-9) and interleukin-8 (IL-8), at the mRNA and protein expression levels, in TPA-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	162-165	C-X-C motif chemokine ligand 8	Homo sapiens	94-107	
31893611-6	2020	Moreover, it inhibited two metastasis-related factors, matrix metalloproteinase-9 (MMP-9) and interleukin-8 (IL-8), at the mRNA and protein expression levels, in TPA-treated MCF-7 cells.	Tetradecanoylphorbol Acetate	162-165	C-X-C motif chemokine ligand 8	Homo sapiens	109-113	
30726114-5	2019	Meanwhile, fMLF or IL-8 stimulation yields the longer terminating time than that on PMA stimulation but results in a similar shedding extent for PMNs.	Tetradecanoylphorbol Acetate	84-87	C-X-C motif chemokine ligand 8	Homo sapiens	19-23	
30248704-0	2019	Serine Protease Mauritanicain from Euphorbia mauritanica and Phorbol-12-myristate-13-acetate Modulate the IL-8 Release in Fibroblasts and HaCaT Keratinocytes.	Tetradecanoylphorbol Acetate	61-92	C-X-C motif chemokine ligand 8	Homo sapiens	106-110	
30248704-7	2019	The results indicated that the combination of the protease mauritanicain from Euphorbia mauritanica and phorbol-12-myristate-13-acetate induced a significantly increased IL-8 release in HaCaT keratinocytes compared to single treatments.	Tetradecanoylphorbol Acetate	104-135	C-X-C motif chemokine ligand 8	Homo sapiens	170-174	
33182021-13	2020	Knocking down NEAT1 expression with an ASO suppressed the expression of CXCL8 and TNF-alpha in PMA/ionomycin-stimulated Jurkat cells.	Tetradecanoylphorbol Acetate	95-98	C-X-C motif chemokine ligand 8	Homo sapiens	72-77	
32448093-4	2020	The active mixture also reduced the production of PGE2 and IL-8 in PMA-induced A549 cells.	Tetradecanoylphorbol Acetate	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	59-63	
31496351-9	2019	PMA-induced NETosis directly upregulated the TLR9/NF-kappaB pathway in macrophages and subsequently initiated the release of IL-8.	Tetradecanoylphorbol Acetate	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	125-129	
31070650-6	2019	Furthermore, TPA obviously assuaged TNF-alpha-evoked up-regulation of IL-8 and IL-6 expression, down-regulation of occludin and ZO-3 expression, and markedly suppressed the activation and protein expression of NF-kappaB p65.	Tetradecanoylphorbol Acetate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	70-74	
30323026-5	2019	Suppression of IL-8 in human embryonic kidney (HEK293) cells that were transformed to express TLR5 was observed not only upon inflammatory stimulation by flagellin but also in response to tumor necrosis factor alpha (TNF-alpha) and phorbol myristate acetate (PMA), despite the fact that the TNF-alpha- and PMA-induced inflammatory pathways reportedly are not TLR5 mediated.	Tetradecanoylphorbol Acetate	259-262	C-X-C motif chemokine ligand 8	Homo sapiens	15-19	
30323026-5	2019	Suppression of IL-8 in human embryonic kidney (HEK293) cells that were transformed to express TLR5 was observed not only upon inflammatory stimulation by flagellin but also in response to tumor necrosis factor alpha (TNF-alpha) and phorbol myristate acetate (PMA), despite the fact that the TNF-alpha- and PMA-induced inflammatory pathways reportedly are not TLR5 mediated.	Tetradecanoylphorbol Acetate	306-309	C-X-C motif chemokine ligand 8	Homo sapiens	15-19	
30513776-9	2018	Serum IL-8 level was positively correlated with CC status, weight loss, sarcopenia, but was negatively correlated with total psoas area (TPA).	Tetradecanoylphorbol Acetate	137-140	C-X-C motif chemokine ligand 8	Homo sapiens	6-10	
27863334-7	2017	Conversely, in phorbol 12-myristate 13-acetate and ionomycin (PMA/Io) stimulated Caco-2 cells, lactobacilli from the omnivorous group and all bifidobacteria significantly down-regulated IL-8.	Tetradecanoylphorbol Acetate	15-46	C-X-C motif chemokine ligand 8	Homo sapiens	186-190	
30466990-0	2018	Orientin inhibits invasion by suppressing MMP-9 and IL-8 expression via the PKCalpha/ ERK/AP-1/STAT3-mediated signaling pathways in TPA-treated MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	132-135	C-X-C motif chemokine ligand 8	Homo sapiens	52-56	
30466990-9	2018	CONCLUSION: Orientin inhibits migratory and invasive responses by suppressing MMP-9 and IL-8 expression through mitigation of TPA-induced PKCalpha and ERK activation, as well as the nuclear translocation of AP-1 and STAT3.	Tetradecanoylphorbol Acetate	126-129	C-X-C motif chemokine ligand 8	Homo sapiens	88-92	
30133131-8	2018	These results indicate that mLU8C-PU inhibits migratory and invasive responses in MCF-7 breast cancer cells by suppressing MMP-9 and IL-8 expression through mitigating TPA-induced PKCalpha, JNK activation, and the nuclear translocation of AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	168-171	C-X-C motif chemokine ligand 8	Homo sapiens	133-137	
27863334-7	2017	Conversely, in phorbol 12-myristate 13-acetate and ionomycin (PMA/Io) stimulated Caco-2 cells, lactobacilli from the omnivorous group and all bifidobacteria significantly down-regulated IL-8.	Tetradecanoylphorbol Acetate	62-65	C-X-C motif chemokine ligand 8	Homo sapiens	186-190	
27503790-6	2016	K1 inhibited both TNF- and phorbol 12-myristate 13-acetate (PMA)-induced NF-kappaB activation, as detected by transcription of synthetic (e.g. luciferase) and natural (e.g. CXCL8) genes controlled by NF-kappaB.	Tetradecanoylphorbol Acetate	27-58	C-X-C motif chemokine ligand 8	Homo sapiens	173-178	
27503790-6	2016	K1 inhibited both TNF- and phorbol 12-myristate 13-acetate (PMA)-induced NF-kappaB activation, as detected by transcription of synthetic (e.g. luciferase) and natural (e.g. CXCL8) genes controlled by NF-kappaB.	Tetradecanoylphorbol Acetate	60-63	C-X-C motif chemokine ligand 8	Homo sapiens	173-178	
25959257-7	2015	One component, 6-methyl-3,5-heptadien-2-one (MHDO), inhibited fMLF- and interleukin 8 (IL-8)-stimulated Ca(2+) flux, fMLF-induced chemotaxis, and PMA-induced ROS production in human neutrophils.	Tetradecanoylphorbol Acetate	146-149	C-X-C motif chemokine ligand 8	Homo sapiens	87-91	
26945908-12	2016	17beta-estradiol inhibits IL8-up-regulated Src downstream target proteins including p-Cas, p-paxillin, p-ERK1/2, p-JNK1/2, MMP9, tPA and uPA.	Tetradecanoylphorbol Acetate	129-132	C-X-C motif chemokine ligand 8	Homo sapiens	26-29	
26668998-7	2015	In vitro, levels of AMPKalpha phosphorylation in phorbol-12- myristate-13-acetate (PMA) differentiated THP-1 cells was detected by immunohistochemistry, IL-8 level in supernatants of cigarette smoke condensate stimulating PMA differentiated THP-1 cells was measured by ELISA.	Tetradecanoylphorbol Acetate	49-81	C-X-C motif chemokine ligand 8	Homo sapiens	153-157	
25559824-11	2015	Finally, PMA + ionomycin stimulation did not induce significant alterations on MSCs phenotype but did increase indoleamine-2,3-dioxygenase (IDO), inducible costimulatory ligand (ICOSL), IL-1beta, IL-8, and TNF-alpha mRNA expression.	Tetradecanoylphorbol Acetate	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	196-200	
25540590-0	2014	Differential NF-kappaB and MAPK activation underlies fluoride- and TPA-mediated CXCL8 (IL-8) induction in lung epithelial cells.	Tetradecanoylphorbol Acetate	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	80-85	
25884029-7	2015	VEGF and IL-8 correlated positively with LDH and PAI-1/tPA ratio and negatively with tPA in both loculated and nonloculated TBPE.	Tetradecanoylphorbol Acetate	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	9-13	
25884029-7	2015	VEGF and IL-8 correlated positively with LDH and PAI-1/tPA ratio and negatively with tPA in both loculated and nonloculated TBPE.	Tetradecanoylphorbol Acetate	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	9-13	
25540590-5	2014	Furthermore, TPA induced a strong, rapid, but transient upregulation of CXCL8 messenger (m)RNA, whereas NaF induced a weaker, more delayed, but persistent upregulation.	Tetradecanoylphorbol Acetate	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	72-77	
25540590-10	2014	The CXCL8 responses by TPA and NaF were reduced by p65-siRNA.	Tetradecanoylphorbol Acetate	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	4-9	
25540590-0	2014	Differential NF-kappaB and MAPK activation underlies fluoride- and TPA-mediated CXCL8 (IL-8) induction in lung epithelial cells.	Tetradecanoylphorbol Acetate	67-70	C-X-C motif chemokine ligand 8	Homo sapiens	87-91	
25540590-3	2014	To approach this, we compared the potential of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), and sodium fluoride (NaF) to induce CXCL8 responses in A549 cells, with emphasis on the importance of nuclear factor kappa B (NF-kappaB)- and mitogen-activated protein kinase (MAPK) signaling.	Tetradecanoylphorbol Acetate	66-102	C-X-C motif chemokine ligand 8	Homo sapiens	146-151	
25540590-3	2014	To approach this, we compared the potential of the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), and sodium fluoride (NaF) to induce CXCL8 responses in A549 cells, with emphasis on the importance of nuclear factor kappa B (NF-kappaB)- and mitogen-activated protein kinase (MAPK) signaling.	Tetradecanoylphorbol Acetate	104-107	C-X-C motif chemokine ligand 8	Homo sapiens	146-151	
25540590-4	2014	Notably, TPA induced a greater release of CXCL8 than did NaF.	Tetradecanoylphorbol Acetate	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	42-47	
23933110-0	2013	Luteolin 8-C-beta-fucopyranoside inhibits invasion and suppresses TPA-induced MMP-9 and IL-8 via ERK/AP-1 and ERK/NF-kappaB signaling in MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	66-69	C-X-C motif chemokine ligand 8	Homo sapiens	88-92	
24779584-5	2014	Expression of IL-8 receptors (CXCR1 and CXCR2) and the LPS receptor TLR4 was similar on neutrophils from young and old subjects, and neutrophils challenged with phorbol-12-myristate-13-acetate (PMA) showed no age-associated differences in ROS or NET production.	Tetradecanoylphorbol Acetate	194-197	C-X-C motif chemokine ligand 8	Homo sapiens	14-18	
24589569-5	2014	TET significantly inhibited the induction of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 by phorbol 12-myristate 13-acetate (PMA) plus A23187.	Tetradecanoylphorbol Acetate	143-174	C-X-C motif chemokine ligand 8	Homo sapiens	135-139	
24589569-5	2014	TET significantly inhibited the induction of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 by phorbol 12-myristate 13-acetate (PMA) plus A23187.	Tetradecanoylphorbol Acetate	176-179	C-X-C motif chemokine ligand 8	Homo sapiens	135-139	
24499192-4	2014	RESULTS: It was found that PCN increased IL-8 release and mRNA expression in Phorbol 12-myristate 13-acetate (PMA) differentiated U937 cells in both a concentration- and time-dependent manner by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA).	Tetradecanoylphorbol Acetate	110-113	C-X-C motif chemokine ligand 8	Homo sapiens	41-45	
23933110-3	2013	We investigated whether LU8C-FP would inhibit MMP-9 activation and IL-8 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 breast cancer cells.	Tetradecanoylphorbol Acetate	124-127	C-X-C motif chemokine ligand 8	Homo sapiens	67-71	
23933110-4	2013	LU8C-FP suppressed TPA-induced MMP-9 and IL-8 secretion and mRNA expression via inhibition of the MAPK signaling pathway and down-regulation of nuclear AP-1 and NF-kappaB.	Tetradecanoylphorbol Acetate	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	41-45	
23764888-5	2013	Arazyme inhibited the secretion of IL-6 and IL-8 due to phorbol 12-myristate 13-acetate and calcium ionophores in human mast cells.	Tetradecanoylphorbol Acetate	56-87	C-X-C motif chemokine ligand 8	Homo sapiens	44-48	
23488631-3	2013	SI, AD, and DM reduced a mean phorbol-12-myristate-13-acetate/ionomycin (PMA/I)-stimulated release of the pro-inflammatory interleukins IL-6 and IL-8 by more than 50% (p < 0.05).	Tetradecanoylphorbol Acetate	30-61	C-X-C motif chemokine ligand 8	Homo sapiens	145-149	
22364122-7	2012	F3 inhibited NO, inducible nitric oxide synthetase (iNOS), and IL-8 in interferon gamma (IFN-gamma)- and phorbol ester (PMA)-induced Caco-2 cells.	Tetradecanoylphorbol Acetate	120-123	C-X-C motif chemokine ligand 8	Homo sapiens	63-67	
23347208-7	2013	THP-1 cells exhibited M2-polarized phenotype markers with high proportion of CD68(+) , CD206(+) and CD204(+) markers after phorbol 12-myristate 13-acetate (PMA) treatment, After co-culturing with TAM cells in a transwell chamber system, EOC cells (SKOV3) increased their IL-8 expression at the level of mRNA and protein.	Tetradecanoylphorbol Acetate	156-159	C-X-C motif chemokine ligand 8	Homo sapiens	271-275	
24049660-11	2013	The significantly increased postchallenge concentrations of IL-2, IL-8, IL-12p70, IL-13, IL-18, IFN- gamma , TNF- alpha , and TGF- beta were released by peripheral blood cells after stimulation with PMA, as compared with both their prechallenge concentrations and with the PBS control values.	Tetradecanoylphorbol Acetate	199-202	C-X-C motif chemokine ligand 8	Homo sapiens	66-70	
22775995-5	2012	The COL17-deficient cells showed an abnormally high IL-8 response after treatment with lipopolysaccharide (LPS), ultraviolet-B radiation or tumor necrosis factor, but exhibited a blunted IL-8 response to phorbol 12-myristate 13-acetate exposure.	Tetradecanoylphorbol Acetate	204-235	C-X-C motif chemokine ligand 8	Homo sapiens	187-191	
21771721-5	2011	12-O-tetradecanoylphorbol 13-acetate-induced differentiation of human U937 monocytes increased the expression and secretion of inflammatory cytokines such as tumor necrosis factor alpha, interleukin (IL)-6 and IL-8.	Tetradecanoylphorbol Acetate	0-36	C-X-C motif chemokine ligand 8	Homo sapiens	210-214	
22009527-5	2012	When these cell lines were primed with CXC chemokine ligand 8 (IL-8), a slight increase in reactive oxygen species production induced by phorbol myristate acetate (PMA) or zymosan A stimuli was observed.	Tetradecanoylphorbol Acetate	137-162	C-X-C motif chemokine ligand 8	Homo sapiens	63-67	
22009527-5	2012	When these cell lines were primed with CXC chemokine ligand 8 (IL-8), a slight increase in reactive oxygen species production induced by phorbol myristate acetate (PMA) or zymosan A stimuli was observed.	Tetradecanoylphorbol Acetate	164-167	C-X-C motif chemokine ligand 8	Homo sapiens	63-67	
22403260-4	2012	CD161(+)CD56(+)LFA-1(-) NK cells produce large amounts of CXCL8 after phorbol myristate acetate (PMA) or cytokine treatment.	Tetradecanoylphorbol Acetate	70-95	C-X-C motif chemokine ligand 8	Homo sapiens	58-63	
22403260-4	2012	CD161(+)CD56(+)LFA-1(-) NK cells produce large amounts of CXCL8 after phorbol myristate acetate (PMA) or cytokine treatment.	Tetradecanoylphorbol Acetate	97-100	C-X-C motif chemokine ligand 8	Homo sapiens	58-63	
22414682-5	2012	RESULTS: The levels of IL-8 and GRO-alpha were significantly increased after treatment with EGF, TGF-alpha, TNF-alpha and TPA by primary cultured granulosa-lutein cells.	Tetradecanoylphorbol Acetate	122-125	C-X-C motif chemokine ligand 8	Homo sapiens	23-27	
19694614-5	2009	In vitro studies using phorbol 12-myristyl 13-acetate (PMA) stimulated macrophage-like THP-1 (mTHP-1) cells were focused on cytotoxicity of both polymers and particles, and their potential to stimulate IL-8 release via the TLR-2 pathway.	Tetradecanoylphorbol Acetate	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	202-206	
19789931-7	2010	Moreover, AAS significantly inhibited production of inflammatory cytokines, tumor necrosis factor (TNF), interleukin (IL)-6, and IL-8 on the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells.	Tetradecanoylphorbol Acetate	141-172	C-X-C motif chemokine ligand 8	Homo sapiens	129-133	
21142820-5	2011	Apigenin significantly inhibits the inductive effect of phorbol 12-myristate 13-acetate (PMA) plus A23187 on the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF).	Tetradecanoylphorbol Acetate	56-87	C-X-C motif chemokine ligand 8	Homo sapiens	193-211	
20164300-5	2010	Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB.	Tetradecanoylphorbol Acetate	80-111	C-X-C motif chemokine ligand 8	Homo sapiens	217-221	
19416633-6	2009	Resveratrol significantly inhibited the PMA plus A23187-induction of inflammatory cytokines such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8.	Tetradecanoylphorbol Acetate	40-43	C-X-C motif chemokine ligand 8	Homo sapiens	159-163	
17662042-9	2008	IFN-gamma inhibited phorbol 12-myristate 13-acetate (PMA)-induced release of IL-8 and CCL1 (by 47 and 38%).	Tetradecanoylphorbol Acetate	20-51	C-X-C motif chemokine ligand 8	Homo sapiens	77-81	
18222974-9	2008	In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells.	Tetradecanoylphorbol Acetate	33-64	C-X-C motif chemokine ligand 8	Homo sapiens	181-185	
17662042-9	2008	IFN-gamma inhibited phorbol 12-myristate 13-acetate (PMA)-induced release of IL-8 and CCL1 (by 47 and 38%).	Tetradecanoylphorbol Acetate	53-56	C-X-C motif chemokine ligand 8	Homo sapiens	77-81	
17207890-5	2007	TNF-alpha stimulated expression of both chemokines, while the PKCalpha/beta activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced only expression of IL-8 and inhibited TNF-alpha-induced RANTES expression.	Tetradecanoylphorbol Acetate	86-123	C-X-C motif chemokine ligand 8	Homo sapiens	157-161	
17220369-4	2007	In this study we show a signaling pathway on the plasma surface of human airway epithelial NCI-H292 cells that regulate IL-8 production in response to a model inflammatory stimulus, phorbol 12-myristate 13-acetate, and a pathophysiological stimulus, gram-negative bacterial lipopolysaccharide.	Tetradecanoylphorbol Acetate	182-213	C-X-C motif chemokine ligand 8	Homo sapiens	120-124	
17433258-8	2007	All peptides tested were effective at preventing IL-8 release from phorbol 12-myristate 13-acetate (PMA)/copper-stimulated human umbilical vein endothelial cells (HUVEC).	Tetradecanoylphorbol Acetate	67-98	C-X-C motif chemokine ligand 8	Homo sapiens	49-53	
17433258-8	2007	All peptides tested were effective at preventing IL-8 release from phorbol 12-myristate 13-acetate (PMA)/copper-stimulated human umbilical vein endothelial cells (HUVEC).	Tetradecanoylphorbol Acetate	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	49-53	
17386409-5	2007	Panepoxydone strongly inhibited hTNF-alpha, IL-8 and NF-kappaB promoter activity in LPS/TPA stimulated MonoMac6 cells with IC(50) values of 0.5-1 microg/ml by blocking the phosphorylation of IkappaB and subsequent binding of the activated NF-kappaB transcription factor to the DNA.	Tetradecanoylphorbol Acetate	88-91	C-X-C motif chemokine ligand 8	Homo sapiens	44-48	
17207890-5	2007	TNF-alpha stimulated expression of both chemokines, while the PKCalpha/beta activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced only expression of IL-8 and inhibited TNF-alpha-induced RANTES expression.	Tetradecanoylphorbol Acetate	125-128	C-X-C motif chemokine ligand 8	Homo sapiens	157-161	
17207890-7	2007	In contrast, it decreased TNF-alpha or TPA-induced IL-8 release.	Tetradecanoylphorbol Acetate	39-42	C-X-C motif chemokine ligand 8	Homo sapiens	51-55	
17207890-10	2007	An AP-1 and a NF-kappaB recognition sites were necessary for full induction of IL-8 promoter activity by TNF-alpha and TPA.	Tetradecanoylphorbol Acetate	119-122	C-X-C motif chemokine ligand 8	Homo sapiens	79-83	
16600024-8	2006	Phorbol myristate acetate-stimulated oxidative burst and IL-8 release by IL-1beta, lipopolysaccharide and GM-CSF in whole blood from mild but not severe asthmatics were inhibited after prednisolone.	Tetradecanoylphorbol Acetate	0-25	C-X-C motif chemokine ligand 8	Homo sapiens	57-61	
17113069-4	2007	Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P<0.05).	Tetradecanoylphorbol Acetate	72-103	C-X-C motif chemokine ligand 8	Homo sapiens	238-242	
17113069-4	2007	Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P<0.05).	Tetradecanoylphorbol Acetate	105-108	C-X-C motif chemokine ligand 8	Homo sapiens	238-242	
16890260-8	2006	Furthermore, AEMD attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-8 and IL-6 secretion in human mast cells.	Tetradecanoylphorbol Acetate	33-64	C-X-C motif chemokine ligand 8	Homo sapiens	122-126	
17079162-4	2007	Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells.	Tetradecanoylphorbol Acetate	18-49	C-X-C motif chemokine ligand 8	Homo sapiens	214-218	
16376386-0	2006	Scoparone inhibits PMA-induced IL-8 and MCP-1 production through suppression of NF-kappaB activation in U937 cells.	Tetradecanoylphorbol Acetate	19-22	C-X-C motif chemokine ligand 8	Homo sapiens	31-35	
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	44-69	C-X-C motif chemokine ligand 8	Homo sapiens	77-81	
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	20-45	C-X-C motif chemokine ligand 8	Homo sapiens	147-160	
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	20-45	C-X-C motif chemokine ligand 8	Homo sapiens	162-166	
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	147-160	
16490927-7	2006	The PKC stimulator, phorbol myristate acetate (PMA), strongly up-regulated CD93 expression on the cell surface of all three cell-lines and induced interleukin-8 (IL-8) production by the U937 cells and interferon-gamma (IFN-gamma) production by the KHYG-1 cells.	Tetradecanoylphorbol Acetate	47-50	C-X-C motif chemokine ligand 8	Homo sapiens	162-166	
15893895-8	2005	CA also inhibited interleukin-8 and tumor necrosis factor-alpha secretion from the phorbol 12-myristate 13-acetate and A23187-induced HMC-1 cells (human mast cell line).	Tetradecanoylphorbol Acetate	83-114	C-X-C motif chemokine ligand 8	Homo sapiens	18-63	
15917399-5	2005	Depletion of PKC by phorbol-12-myristate-13-acetate (10 microM) blocked SP-induced IkappaBalpha and p65 phosphorylation and IL-8 production.	Tetradecanoylphorbol Acetate	20-51	C-X-C motif chemokine ligand 8	Homo sapiens	124-128	
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	44-69	C-X-C motif chemokine ligand 8	Homo sapiens	150-154	
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	44-69	C-X-C motif chemokine ligand 8	Homo sapiens	150-154	
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	77-81	
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	150-154	
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	71-74	C-X-C motif chemokine ligand 8	Homo sapiens	150-154	
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	182-185	C-X-C motif chemokine ligand 8	Homo sapiens	77-81	
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	182-185	C-X-C motif chemokine ligand 8	Homo sapiens	150-154	
16103413-5	2005	After treating the HeLa cells for 20 h with phorbol myristate acetate (PMA), IL-8 mRNA levels were induced by almost 50-fold; transfection with 30 nM IL-8-specific siRNA reduced the PMA-induced IL-8 mRNA by 80%.	Tetradecanoylphorbol Acetate	182-185	C-X-C motif chemokine ligand 8	Homo sapiens	150-154	
15746434-3	2005	We found that the IL-8 mRNA expression in lung cancer cells significantly increased after coculture with phorbol myristate acetate-treated THP-1 cells and human primary lung macrophages.	Tetradecanoylphorbol Acetate	105-130	C-X-C motif chemokine ligand 8	Homo sapiens	18-22	
16091123-2	2005	This study aimed to examine the signal pathway in the production of cytokines [interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha)] by ROS generated from phorbol myristate acetate (PMA)-stimulated human mast cell line-1 cells (HMC-1).	Tetradecanoylphorbol Acetate	168-193	C-X-C motif chemokine ligand 8	Homo sapiens	79-92	
16091123-2	2005	This study aimed to examine the signal pathway in the production of cytokines [interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha)] by ROS generated from phorbol myristate acetate (PMA)-stimulated human mast cell line-1 cells (HMC-1).	Tetradecanoylphorbol Acetate	168-193	C-X-C motif chemokine ligand 8	Homo sapiens	94-98	
16091123-2	2005	This study aimed to examine the signal pathway in the production of cytokines [interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha)] by ROS generated from phorbol myristate acetate (PMA)-stimulated human mast cell line-1 cells (HMC-1).	Tetradecanoylphorbol Acetate	195-198	C-X-C motif chemokine ligand 8	Homo sapiens	79-92	
16091123-2	2005	This study aimed to examine the signal pathway in the production of cytokines [interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha)] by ROS generated from phorbol myristate acetate (PMA)-stimulated human mast cell line-1 cells (HMC-1).	Tetradecanoylphorbol Acetate	195-198	C-X-C motif chemokine ligand 8	Homo sapiens	94-98	
15588914-3	2005	DON (62.5-500 ng/ml) also significantly upregulated IL-2 and IL-8 production following prestimulation with phorbol myristate acetate and ionomycin.	Tetradecanoylphorbol Acetate	107-132	C-X-C motif chemokine ligand 8	Homo sapiens	61-65	
15760676-5	2005	Using PMA (a potent pharmacological activator of PKC) and calphostin C (a specific PKC inhibitor), we demonstrated an up-regulation of IL-8 in NCTC 2544 cells and a down-regulation of the cytokine in UVB-irradiated cells, respectively.	Tetradecanoylphorbol Acetate	6-9	C-X-C motif chemokine ligand 8	Homo sapiens	135-139	
15654514-4	2004	RESULTS: HMC-1 produced substantial amounts of GM-CSF and IL-8 and smaller amounts of TNF-alpha, IL-4 and IL-6 after being stimulated with PMA together with A23187.	Tetradecanoylphorbol Acetate	139-142	C-X-C motif chemokine ligand 8	Homo sapiens	58-62	
15286717-3	2004	Combined treatment with Ca(2+)-ionophore and phorbol-myristate-acetate (A23187/PMA) increased IL-8 mRNA and protein levels.	Tetradecanoylphorbol Acetate	45-70	C-X-C motif chemokine ligand 8	Homo sapiens	94-98