PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8036020-4 1994 Interestingly, the effects of TPA are mimicked by the protein kinase inhibitor, staurosporine, which induces the expression of TPA target genes such as the neuronal differentiation-associated gene NPY in SH-SY5Y cells. Tetradecanoylphorbol Acetate 30-33 neuropeptide Y Homo sapiens 197-200 8036020-4 1994 Interestingly, the effects of TPA are mimicked by the protein kinase inhibitor, staurosporine, which induces the expression of TPA target genes such as the neuronal differentiation-associated gene NPY in SH-SY5Y cells. Tetradecanoylphorbol Acetate 127-130 neuropeptide Y Homo sapiens 197-200 8036020-8 1994 Both staurosporine and TPA enhanced and modulated the binding of these DNA-protein complexes concomitant with the NPY mRNA expression. Tetradecanoylphorbol Acetate 23-26 neuropeptide Y Homo sapiens 114-117 8036020-11 1994 These protein complexes appear to contribute to the cell specific expression of the NPY gene and seem to be required during differentiation of SH-SY5Y human neuroblastoma cells further along the sympathetic neuronal lineage induced by either TPA or staurosporine. Tetradecanoylphorbol Acetate 242-245 neuropeptide Y Homo sapiens 84-87 12030804-4 2001 Pretreatment with phorbol 12-myristate 13-acetate (PMA) completely abolished these effects for both NE and NPY. Tetradecanoylphorbol Acetate 18-49 neuropeptide Y Homo sapiens 107-110 8123590-5 1994 DNA-protein interaction between an evolutionarily conserved region (-73 to -45) of the human NPY promoter, containing potential binding sites for AP-1, AP-2, and Sp1, and nuclear extracts prepared from untreated and TPA-treated SH-SY5Y cells revealed one complex (CI) that was unaffected and three complexes (CII to CIV) that were induced by TPA treatment. Tetradecanoylphorbol Acetate 216-219 neuropeptide Y Homo sapiens 93-96 8123590-7 1994 In addition, TPA-mediated induction of AP-2 DNA binding activity to the NPY promoter was not dependent on increased AP-2 mRNA expression. Tetradecanoylphorbol Acetate 13-16 neuropeptide Y Homo sapiens 72-75 23994577-4 2013 In addition, 12-O-tetradecanoylphorbol-13-acetate (TPA) known to differentiate SH-SY5Y cells into a neuronal phenotype and to increase NPY expression through activation of protein kinase C (PKC) was applied as a positive control (16nM). Tetradecanoylphorbol Acetate 51-54 neuropeptide Y Homo sapiens 135-138 23994577-8 2013 A further increase in expression was observed with simultaneous VPA and TPA treatment, suggesting that the two agents may increase NPY expression through different mechanisms. Tetradecanoylphorbol Acetate 72-75 neuropeptide Y Homo sapiens 131-134 23994577-9 2013 The increase in NPY mRNA by VPA and TPA was confirmed with qRT-PCR after 72h. Tetradecanoylphorbol Acetate 36-39 neuropeptide Y Homo sapiens 16-19 11707282-4 2001 On the other hand, PKCbeta inhibition suppressed the TPA-stimulated increase in neuropeptide Y mRNA, activation of neuropeptide Y gene promoter elements, and phosphorylation of Erk1/2. Tetradecanoylphorbol Acetate 53-56 neuropeptide Y Homo sapiens 80-94 11707282-4 2001 On the other hand, PKCbeta inhibition suppressed the TPA-stimulated increase in neuropeptide Y mRNA, activation of neuropeptide Y gene promoter elements, and phosphorylation of Erk1/2. Tetradecanoylphorbol Acetate 53-56 neuropeptide Y Homo sapiens 115-129 11707282-5 2001 The TPA-induced increase in neuropeptide Y expression was also inhibited by the MEK inhibitor PD98059. Tetradecanoylphorbol Acetate 4-7 neuropeptide Y Homo sapiens 28-42 8157736-5 1994 Monocytes and in vitro matured macrophages expressed NPY mRNA in response to phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 77-102 neuropeptide Y Homo sapiens 53-56 8157736-5 1994 Monocytes and in vitro matured macrophages expressed NPY mRNA in response to phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 104-107 neuropeptide Y Homo sapiens 53-56 8280132-5 1993 In addition, GF 109203X completely inhibited TPA-induced increase in cellular content of noradrenaline as well as stimulation of expression of neuropeptide Y, growth-associated protein-43 and c-fos proto-oncogene mRNA by TPA. Tetradecanoylphorbol Acetate 221-224 neuropeptide Y Homo sapiens 143-157 1279891-3 1992 Treatment with Bt2cAMP and TPA markedly increased the number of cells immunoreactive to VIP, PHM, neuropeptide Y, Met-enkephalin, substance P and tyrosine hydroxylase and also the contents of VIP and Met-enkephalin in the culture medium. Tetradecanoylphorbol Acetate 27-30 neuropeptide Y Homo sapiens 98-112 18619673-6 2008 In contrast, PMA treatment (but not forskolin) resulted in a 2-fold increase in production of galanin and somatostatin, and a 3-fold increase in NPY production. Tetradecanoylphorbol Acetate 13-16 neuropeptide Y Homo sapiens 145-148 12030804-4 2001 Pretreatment with phorbol 12-myristate 13-acetate (PMA) completely abolished these effects for both NE and NPY. Tetradecanoylphorbol Acetate 51-54 neuropeptide Y Homo sapiens 107-110 9802422-7 1998 Moreover, PMA induced the accumulation of mRNA corresponding in size to the neuronal NPY-mRNA. Tetradecanoylphorbol Acetate 10-13 neuropeptide Y Homo sapiens 85-88 9572272-1 1998 Activated transcription of the human neuropeptide Y gene (NPY) was investigated in SH-SY5Y neuroblastoma cells at the onset of sympathetic neuronal differentiation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) and serum or by nerve growth factor (NGF). Tetradecanoylphorbol Acetate 175-211 neuropeptide Y Homo sapiens 37-51 9572272-1 1998 Activated transcription of the human neuropeptide Y gene (NPY) was investigated in SH-SY5Y neuroblastoma cells at the onset of sympathetic neuronal differentiation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) and serum or by nerve growth factor (NGF). Tetradecanoylphorbol Acetate 175-211 neuropeptide Y Homo sapiens 58-61 9572272-1 1998 Activated transcription of the human neuropeptide Y gene (NPY) was investigated in SH-SY5Y neuroblastoma cells at the onset of sympathetic neuronal differentiation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) and serum or by nerve growth factor (NGF). Tetradecanoylphorbol Acetate 213-216 neuropeptide Y Homo sapiens 37-51 9572272-1 1998 Activated transcription of the human neuropeptide Y gene (NPY) was investigated in SH-SY5Y neuroblastoma cells at the onset of sympathetic neuronal differentiation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) and serum or by nerve growth factor (NGF). Tetradecanoylphorbol Acetate 213-216 neuropeptide Y Homo sapiens 58-61 9572272-3 1998 TPA treatment in the presence of serum induced NPY transcription in both wild-type SH-SY5Y (SH-SY5Y/wt) and SH-SY5Y/trk cells. Tetradecanoylphorbol Acetate 0-3 neuropeptide Y Homo sapiens 47-50 9572272-5 1998 Suppression of TPA-induced NPY transcription was obtained by expression of a dominant negative Jun protein, selective protein kinase C inhibition, or introduction of a mutated TRE, whereas NGF-induced NPY transcription was inhibited to a lesser degree. Tetradecanoylphorbol Acetate 15-18 neuropeptide Y Homo sapiens 27-30 7790925-10 1995 Regulation of the protein kinase C pathway with phorbol myristate acetate (PMA) stimulated SCG neuronal NPY secretion to a lesser degree than activation of protein kinase A, but did not alter cellular NPY levels. Tetradecanoylphorbol Acetate 48-73 neuropeptide Y Homo sapiens 104-107 8884387-3 1996 The NPY production in response to forskolin and phorbol 12-myristate 13-acetate (PMA) was taken as a criterion for regulated expression of NPY. Tetradecanoylphorbol Acetate 48-79 neuropeptide Y Homo sapiens 4-7 8884387-3 1996 The NPY production in response to forskolin and phorbol 12-myristate 13-acetate (PMA) was taken as a criterion for regulated expression of NPY. Tetradecanoylphorbol Acetate 48-79 neuropeptide Y Homo sapiens 139-142 8884387-3 1996 The NPY production in response to forskolin and phorbol 12-myristate 13-acetate (PMA) was taken as a criterion for regulated expression of NPY. Tetradecanoylphorbol Acetate 81-84 neuropeptide Y Homo sapiens 4-7 8884387-3 1996 The NPY production in response to forskolin and phorbol 12-myristate 13-acetate (PMA) was taken as a criterion for regulated expression of NPY. Tetradecanoylphorbol Acetate 81-84 neuropeptide Y Homo sapiens 139-142 8884387-7 1996 Thus, forskolin + PMA led to an increased production of NPY. Tetradecanoylphorbol Acetate 18-21 neuropeptide Y Homo sapiens 56-59 8884387-8 1996 Exposure to PMA alone led to an increase in NPY production comparable to that seen after forskolin + PMA and this effect of PMA was dose-dependent. Tetradecanoylphorbol Acetate 12-15 neuropeptide Y Homo sapiens 44-47 7790925-10 1995 Regulation of the protein kinase C pathway with phorbol myristate acetate (PMA) stimulated SCG neuronal NPY secretion to a lesser degree than activation of protein kinase A, but did not alter cellular NPY levels. Tetradecanoylphorbol Acetate 75-78 neuropeptide Y Homo sapiens 104-107 7867591-3 1995 We report that the effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) and forskolin on a neuroblastoma cell line (LA-N-5) and a pheochromocytoma cell line (PC12) are mediated through both increased transcription of the NPY gene and through stabilization of NPY messenger RNA (mRNA). Tetradecanoylphorbol Acetate 30-67 neuropeptide Y Homo sapiens 223-226 7867591-3 1995 We report that the effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) and forskolin on a neuroblastoma cell line (LA-N-5) and a pheochromocytoma cell line (PC12) are mediated through both increased transcription of the NPY gene and through stabilization of NPY messenger RNA (mRNA). Tetradecanoylphorbol Acetate 30-67 neuropeptide Y Homo sapiens 261-264 7867591-4 1995 After 8 h of treatment TPA and forskolin increase the steady-state level of NPY mRNA 10- and 12-fold in LA-N-5 and PC12 cells, respectively. Tetradecanoylphorbol Acetate 23-26 neuropeptide Y Homo sapiens 76-79 7867591-3 1995 We report that the effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) and forskolin on a neuroblastoma cell line (LA-N-5) and a pheochromocytoma cell line (PC12) are mediated through both increased transcription of the NPY gene and through stabilization of NPY messenger RNA (mRNA). Tetradecanoylphorbol Acetate 69-72 neuropeptide Y Homo sapiens 223-226 7867591-8 1995 Thus, these experiments demonstrate that TPA and forskolin effect the regulation of the NPY gene via transcriptional and posttranscriptional mechanisms in a cell-specific manner. Tetradecanoylphorbol Acetate 41-44 neuropeptide Y Homo sapiens 88-91 7867591-3 1995 We report that the effects of 12-O-tetradecanoyl phorbol-13-acetate (TPA) and forskolin on a neuroblastoma cell line (LA-N-5) and a pheochromocytoma cell line (PC12) are mediated through both increased transcription of the NPY gene and through stabilization of NPY messenger RNA (mRNA). Tetradecanoylphorbol Acetate 69-72 neuropeptide Y Homo sapiens 261-264