PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9583193-4	1998	The anti-CD3 monoclonal antibody-induced expression of interleukin-2 receptor alpha chain (IL-2R/CD25) was significantly suppressed; however, the addition of phorbol 12-myristate 13-acetate or ionomycin caused a remarkable recovery of CD25 expression.	Tetradecanoylphorbol Acetate	158-189	interleukin 2 receptor subunit alpha	Homo sapiens	91-96	
9682002-6	1998	Lymphocytes which have been exposed to dexamethasone in vitro retained the ability to express CD40L after incubation in medium alone for 48 h. Dexamethasone also inhibited PMA/ionomycin induced IL-2 and IFN-gamma production but not CD25 and CD69 expression.	Tetradecanoylphorbol Acetate	172-175	interleukin 2 receptor subunit alpha	Homo sapiens	232-236	
17355247-10	2007	Moreover, leptin enhanced the expression of CD69 and CD25 on CD4(+) and CD8(+) cells after stimulation with PMA-ionomycin.	Tetradecanoylphorbol Acetate	108-111	interleukin 2 receptor subunit alpha	Homo sapiens	53-57	
10985305-4	2000	Stimulation of these cells with anti-CD28 antibody, and either phorbol 12-myristate 13-acetate (PMA) or anti-CD3, activates signal transduction pathways and results in IL-2 production and IL-2 receptor alpha-chain (CD25) expression.	Tetradecanoylphorbol Acetate	63-94	interleukin 2 receptor subunit alpha	Homo sapiens	215-219	
10985305-4	2000	Stimulation of these cells with anti-CD28 antibody, and either phorbol 12-myristate 13-acetate (PMA) or anti-CD3, activates signal transduction pathways and results in IL-2 production and IL-2 receptor alpha-chain (CD25) expression.	Tetradecanoylphorbol Acetate	96-99	interleukin 2 receptor subunit alpha	Homo sapiens	215-219	
10632964-4	2000	Ovine US caused dose-dependent inhibition of lymphocyte proliferation induced by phorbol myristol acetate (PMA), an activator of protein kinase C. The PHA-induced increase in CD25 expression was inhibited in peripheral blood mononuclear leukocytes (PBML) by OvUS.	Tetradecanoylphorbol Acetate	107-110	interleukin 2 receptor subunit alpha	Homo sapiens	175-179	
9583193-4	1998	The anti-CD3 monoclonal antibody-induced expression of interleukin-2 receptor alpha chain (IL-2R/CD25) was significantly suppressed; however, the addition of phorbol 12-myristate 13-acetate or ionomycin caused a remarkable recovery of CD25 expression.	Tetradecanoylphorbol Acetate	158-189	interleukin 2 receptor subunit alpha	Homo sapiens	97-101	
9583193-4	1998	The anti-CD3 monoclonal antibody-induced expression of interleukin-2 receptor alpha chain (IL-2R/CD25) was significantly suppressed; however, the addition of phorbol 12-myristate 13-acetate or ionomycin caused a remarkable recovery of CD25 expression.	Tetradecanoylphorbol Acetate	158-189	interleukin 2 receptor subunit alpha	Homo sapiens	235-239	
9367861-1	1997	Mobile lipid levels, IL-2R alpha expression and proliferation increased after treatment with PMA and ionomycin.	Tetradecanoylphorbol Acetate	93-96	interleukin 2 receptor subunit alpha	Homo sapiens	21-32	
9367861-2	1997	PMA or ionomycin stimulation alone induced increased IL-2R alpha expression but not proliferation.	Tetradecanoylphorbol Acetate	0-3	interleukin 2 receptor subunit alpha	Homo sapiens	53-64	
9111583-4	1997	When stimulated with anti-CD3 mAb plus phorbol 12-myristate 13-acetate (PMA), CD25 expression was clearly restored in certain cases of ALL.	Tetradecanoylphorbol Acetate	39-70	interleukin 2 receptor subunit alpha	Homo sapiens	78-82	
9111583-4	1997	When stimulated with anti-CD3 mAb plus phorbol 12-myristate 13-acetate (PMA), CD25 expression was clearly restored in certain cases of ALL.	Tetradecanoylphorbol Acetate	72-75	interleukin 2 receptor subunit alpha	Homo sapiens	78-82	
7606799-4	1995	Phorbol ester (PMA), a direct activator of PKC, provoked LHRH production and cell surface expression of CD69 and IL-2R molecules by T cells, but not IL-2 synthesis.	Tetradecanoylphorbol Acetate	15-18	interleukin 2 receptor subunit alpha	Homo sapiens	113-118	
7554401-5	1995	Importantly, the levels of mRNA encoding c-myc, IL-2R alpha, IL-2 and IFN-gamma were markedly decreased in patient lymphocytes stimulated with PMA+ionomycin as compared to control lymphocytes.	Tetradecanoylphorbol Acetate	143-146	interleukin 2 receptor subunit alpha	Homo sapiens	48-59	
9306153-0	1997	Ouabain effects on activated lymphocytes: augmentation of CD25 expression on TPA-stimulated cells and of CD69 on PHA-and TPA-stimulated cells.	Tetradecanoylphorbol Acetate	77-80	interleukin 2 receptor subunit alpha	Homo sapiens	58-62	
9306153-4	1997	Conversely, cultures activated by TPA and OUA showed an increased expression of CD25.	Tetradecanoylphorbol Acetate	34-37	interleukin 2 receptor subunit alpha	Homo sapiens	80-84	
8633191-4	1996	The expression of the IL-2R by lymphocytes was also resistant to NDGA concentrations that effectively blocked the mitogenic effects of TPA or bryostatin, but could be inhibited by higher concentrations of NDGA (IC50 = 8 microM).	Tetradecanoylphorbol Acetate	135-138	interleukin 2 receptor subunit alpha	Homo sapiens	22-27	
8206753-4	1994	In T cells stimulated with purified phytohemagglutinin (PHA-p) and 4 beta-phorbol 12-myristate 13-acetate (PMA) addition of DM to the cultures resulted in a 60% reduction in IL-2R alpha and a 30% reduction in IL-2R beta membrane expression compared to T cells cultured in the absence of DM (p < 0.01).	Tetradecanoylphorbol Acetate	67-105	interleukin 2 receptor subunit alpha	Homo sapiens	174-185	
7645378-6	1995	However, the addition of phorbol 12-myristate 13-acetate (PMA) caused the significant recovery of CD25 expression.	Tetradecanoylphorbol Acetate	25-56	interleukin 2 receptor subunit alpha	Homo sapiens	98-102	
7645378-6	1995	However, the addition of phorbol 12-myristate 13-acetate (PMA) caused the significant recovery of CD25 expression.	Tetradecanoylphorbol Acetate	58-61	interleukin 2 receptor subunit alpha	Homo sapiens	98-102	
7517692-5	1994	After stimulation by TPA for 3 days, only the appearance of CD25 (Tac antigen) was detected by immunofluorescence and flow cytometry.	Tetradecanoylphorbol Acetate	21-24	interleukin 2 receptor subunit alpha	Homo sapiens	60-64	
7517692-5	1994	After stimulation by TPA for 3 days, only the appearance of CD25 (Tac antigen) was detected by immunofluorescence and flow cytometry.	Tetradecanoylphorbol Acetate	21-24	interleukin 2 receptor subunit alpha	Homo sapiens	66-77	
8206753-4	1994	In T cells stimulated with purified phytohemagglutinin (PHA-p) and 4 beta-phorbol 12-myristate 13-acetate (PMA) addition of DM to the cultures resulted in a 60% reduction in IL-2R alpha and a 30% reduction in IL-2R beta membrane expression compared to T cells cultured in the absence of DM (p < 0.01).	Tetradecanoylphorbol Acetate	107-110	interleukin 2 receptor subunit alpha	Homo sapiens	174-185	
8455941-5	1993	Moreover, whereas both Tax and phorbol 12-myristate 13-acetate (PMA) are able to efficiently induce the binding of NF-kappa B to the IL-2R alpha kappa B site, PMA is functionally inactive.	Tetradecanoylphorbol Acetate	31-62	interleukin 2 receptor subunit alpha	Homo sapiens	133-144	
8258145-6	1993	H47 mAb also enhanced PMA-induced interleukin-2 receptor (IL-2R) expression and IL-2 synthesis, but did not induce a change in intracellular free calcium ([Ca2+]i) of T cells.	Tetradecanoylphorbol Acetate	22-25	interleukin 2 receptor subunit alpha	Homo sapiens	34-56	
8258145-6	1993	H47 mAb also enhanced PMA-induced interleukin-2 receptor (IL-2R) expression and IL-2 synthesis, but did not induce a change in intracellular free calcium ([Ca2+]i) of T cells.	Tetradecanoylphorbol Acetate	22-25	interleukin 2 receptor subunit alpha	Homo sapiens	58-63	
8324074-0	1993	Induction of interleukin-2 receptor alpha-chain gene expression by cytochalasin B and 12-O-tetradecanoylphorbol-13-acetate in T lymphocytes.	Tetradecanoylphorbol Acetate	86-122	interleukin 2 receptor subunit alpha	Homo sapiens	13-41	
8324074-4	1993	In this study, we examined the effect of cytochalasin B (CB) plus 12-O-tetradecanoylphorbol-13-acetate (TPA) on expression of IL-2 and IL-2R.	Tetradecanoylphorbol Acetate	66-102	interleukin 2 receptor subunit alpha	Homo sapiens	135-140	
8324074-4	1993	In this study, we examined the effect of cytochalasin B (CB) plus 12-O-tetradecanoylphorbol-13-acetate (TPA) on expression of IL-2 and IL-2R.	Tetradecanoylphorbol Acetate	104-107	interleukin 2 receptor subunit alpha	Homo sapiens	135-140	
8324074-7	1993	Unlike the cells treated individually with CB or TPA, cells treated with CB plus TPA accumulated IL-2R mRNA at all the times examined.	Tetradecanoylphorbol Acetate	81-84	interleukin 2 receptor subunit alpha	Homo sapiens	97-102	
8455941-5	1993	Moreover, whereas both Tax and phorbol 12-myristate 13-acetate (PMA) are able to efficiently induce the binding of NF-kappa B to the IL-2R alpha kappa B site, PMA is functionally inactive.	Tetradecanoylphorbol Acetate	64-67	interleukin 2 receptor subunit alpha	Homo sapiens	133-144	
1394441-3	1992	After stimulation with phytohemagglutinin (PHA) and phorbol myristate acetate (PMA), Tat transfectants with high Tat expression showed diminished expression of interleukin-2 (IL-2) and the interleukin-2 receptor alpha chain (IL-2R) when compared to untransfected Jurkat cells or Jurkat cell lines transfected with the parent control plasmid.	Tetradecanoylphorbol Acetate	52-77	interleukin 2 receptor subunit alpha	Homo sapiens	225-230	
1333455-3	1992	Okadaic acid at up to 4 nM enhanced phorbol myristate acetate (PMA)-induced proliferation and CD25 (IL-2 receptor, p55) expression, although it showed no activation by itself.	Tetradecanoylphorbol Acetate	36-61	interleukin 2 receptor subunit alpha	Homo sapiens	94-98	
1333455-3	1992	Okadaic acid at up to 4 nM enhanced phorbol myristate acetate (PMA)-induced proliferation and CD25 (IL-2 receptor, p55) expression, although it showed no activation by itself.	Tetradecanoylphorbol Acetate	36-61	interleukin 2 receptor subunit alpha	Homo sapiens	115-118	
1333455-3	1992	Okadaic acid at up to 4 nM enhanced phorbol myristate acetate (PMA)-induced proliferation and CD25 (IL-2 receptor, p55) expression, although it showed no activation by itself.	Tetradecanoylphorbol Acetate	63-66	interleukin 2 receptor subunit alpha	Homo sapiens	94-98	
1388136-3	1992	TPA-induced T-cell proliferation, expression of interleukin-2 receptor-alpha subunit (IL-2R alpha) and transferrin receptor, CD3 down-regulation and, lastly, the cytosol-to-membrane PKC translocation (determined by an enzymatic assay or by immunoblotting with a cross-reactive anti-PKC peptide antibody) were all facilitated by ionomycin.	Tetradecanoylphorbol Acetate	0-3	interleukin 2 receptor subunit alpha	Homo sapiens	86-97	
1333455-3	1992	Okadaic acid at up to 4 nM enhanced phorbol myristate acetate (PMA)-induced proliferation and CD25 (IL-2 receptor, p55) expression, although it showed no activation by itself.	Tetradecanoylphorbol Acetate	63-66	interleukin 2 receptor subunit alpha	Homo sapiens	115-118	
1307243-4	1992	Co-stimulation with PHA + phorbol myristate acetate in the absence of AC restored both proliferation and CD25 expression in the aged.	Tetradecanoylphorbol Acetate	26-51	interleukin 2 receptor subunit alpha	Homo sapiens	105-109	
1588792-0	1992	Phorbol myristate acetate-induced expression of high-affinity interleukin 2 receptors and production of interleukin 2 by human acute lymphoblastic leukemia T cells.	Tetradecanoylphorbol Acetate	0-25	interleukin 2 receptor subunit alpha	Homo sapiens	62-85	
1588792-1	1992	The effect of phorbol myristate acetate (PMA) on the expression of interleukin 2 receptors (IL-2R), production of IL-2 and IL-2-dependent proliferation of acute lymphoblastic leukemia T cells (T-ALL cells) from 10 patients was studied.	Tetradecanoylphorbol Acetate	41-44	interleukin 2 receptor subunit alpha	Homo sapiens	67-90	
1588792-1	1992	The effect of phorbol myristate acetate (PMA) on the expression of interleukin 2 receptors (IL-2R), production of IL-2 and IL-2-dependent proliferation of acute lymphoblastic leukemia T cells (T-ALL cells) from 10 patients was studied.	Tetradecanoylphorbol Acetate	41-44	interleukin 2 receptor subunit alpha	Homo sapiens	92-97	
1588792-5	1992	We found that PMA induced the expression of both IL-2R alpha and IL-2R beta chains, as well as IL-2 production by T-ALL cells.	Tetradecanoylphorbol Acetate	14-17	interleukin 2 receptor subunit alpha	Homo sapiens	49-60	
1588792-8	1992	In two cases tested high-affinity IL-2R on PMA-treated T-ALL cells could internalize 125I-rIL-2 at 37 degrees C. PMA alone enhanced the spontaneous proliferation of T-ALL cells in three cases, whereas a clear synergy between IL-2 and PMA could be detected in three patients" cells.	Tetradecanoylphorbol Acetate	43-46	interleukin 2 receptor subunit alpha	Homo sapiens	34-39	
1309491-2	1992	STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	186-217	interleukin 2 receptor subunit alpha	Homo sapiens	87-92	
1309491-2	1992	STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	186-217	interleukin 2 receptor subunit alpha	Homo sapiens	93-96	
1309491-2	1992	STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	219-222	interleukin 2 receptor subunit alpha	Homo sapiens	87-92	
1309491-2	1992	STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	219-222	interleukin 2 receptor subunit alpha	Homo sapiens	93-96	
1371954-2	1992	Interestingly, LAM exhibited a down-regulatory effect on the accumulation of mRNAs for IL-2, IL-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-2 receptor alpha (IL-2R alpha) in T cells co-stimulated with phytohaemagglutinin-P (PHA) and 4 beta-phorbol-12-myristyl-13-acetate (PMA).	Tetradecanoylphorbol Acetate	297-300	interleukin 2 receptor subunit alpha	Homo sapiens	183-194	
1907694-5	1991	Phorbol myristate acetate which is known to be protein kinase C (PKC) activator induced IL-2R on monocytes, and PKC inhibitor, H7, inhibited IFN-gamma-induced IL-2R on monocytes in healthy controls.	Tetradecanoylphorbol Acetate	0-25	interleukin 2 receptor subunit alpha	Homo sapiens	88-93	
2026453-1	1991	The role of phorbol myristate acetate (PMA: a protein kinase-C (PKC) activator) and calcium ionophore A23187 in the induction mechanism of the interleukin 2 receptor (IL2R) on B-cell chronic lymphocytic leukemia (B-CLL) cells was studied.	Tetradecanoylphorbol Acetate	12-37	interleukin 2 receptor subunit alpha	Homo sapiens	143-165	
2011401-2	1991	Treating JURKAT cells with the phorbol ester tetradecanoyl phorbol acetate (TPA) inhibited their proliferation and induced expression of the gene for the interleukin 2 receptor alpha chain (IL2R-alpha), consistent with previous reports.	Tetradecanoylphorbol Acetate	76-79	interleukin 2 receptor subunit alpha	Homo sapiens	190-200	
2011401-4	1991	In contrast, accumulation of mRNAs for the C-FOS, C-JUN, and EGR-1 genes increased markedly in TPA-treated cells and preceded the induction of IL2R-alpha mRNA.	Tetradecanoylphorbol Acetate	95-98	interleukin 2 receptor subunit alpha	Homo sapiens	143-153	
2011401-7	1991	Despite sustained expression of C-MYC, BCL2, or the combination of these protooncogenes, TPA continued to inhibit JURKAT cell growth and to induce IL2R expression.	Tetradecanoylphorbol Acetate	89-92	interleukin 2 receptor subunit alpha	Homo sapiens	147-151	
2026453-4	1991	Radiolabeled IL2 binding assays also demonstrated that PMA induced both high-affinity IL2R (HA-IL2R) and low-affinity IL2R (LA-IL2R) on B-CLL cells, but that A23187 did not.	Tetradecanoylphorbol Acetate	55-58	interleukin 2 receptor subunit alpha	Homo sapiens	86-90	
2026453-4	1991	Radiolabeled IL2 binding assays also demonstrated that PMA induced both high-affinity IL2R (HA-IL2R) and low-affinity IL2R (LA-IL2R) on B-CLL cells, but that A23187 did not.	Tetradecanoylphorbol Acetate	55-58	interleukin 2 receptor subunit alpha	Homo sapiens	95-99	
2026453-4	1991	Radiolabeled IL2 binding assays also demonstrated that PMA induced both high-affinity IL2R (HA-IL2R) and low-affinity IL2R (LA-IL2R) on B-CLL cells, but that A23187 did not.	Tetradecanoylphorbol Acetate	55-58	interleukin 2 receptor subunit alpha	Homo sapiens	95-99	
2026453-4	1991	Radiolabeled IL2 binding assays also demonstrated that PMA induced both high-affinity IL2R (HA-IL2R) and low-affinity IL2R (LA-IL2R) on B-CLL cells, but that A23187 did not.	Tetradecanoylphorbol Acetate	55-58	interleukin 2 receptor subunit alpha	Homo sapiens	95-99	
2026453-5	1991	After treatment with PMA, three of five cases did not respond to IL2 even though they expressed HA-IL2R, suggesting impaired signal transduction.	Tetradecanoylphorbol Acetate	21-24	interleukin 2 receptor subunit alpha	Homo sapiens	99-103	
2026453-1	1991	The role of phorbol myristate acetate (PMA: a protein kinase-C (PKC) activator) and calcium ionophore A23187 in the induction mechanism of the interleukin 2 receptor (IL2R) on B-cell chronic lymphocytic leukemia (B-CLL) cells was studied.	Tetradecanoylphorbol Acetate	12-37	interleukin 2 receptor subunit alpha	Homo sapiens	167-171	
2026453-1	1991	The role of phorbol myristate acetate (PMA: a protein kinase-C (PKC) activator) and calcium ionophore A23187 in the induction mechanism of the interleukin 2 receptor (IL2R) on B-cell chronic lymphocytic leukemia (B-CLL) cells was studied.	Tetradecanoylphorbol Acetate	39-42	interleukin 2 receptor subunit alpha	Homo sapiens	143-165	
2026453-1	1991	The role of phorbol myristate acetate (PMA: a protein kinase-C (PKC) activator) and calcium ionophore A23187 in the induction mechanism of the interleukin 2 receptor (IL2R) on B-cell chronic lymphocytic leukemia (B-CLL) cells was studied.	Tetradecanoylphorbol Acetate	39-42	interleukin 2 receptor subunit alpha	Homo sapiens	167-171	
2494663-1	1989	We have investigated the biochemical basis for the activation of interleukin 2 receptor alpha-subunit (IL-2R alpha) gene expression in primary human T lymphocytes by a cytokine (tumor necrosis factor alpha), a T-cell mitogen (phorbol 12-myristate 13-acetate), and the transactivator protein (Tax) from the type I human T-cell leukemia virus.	Tetradecanoylphorbol Acetate	226-257	interleukin 2 receptor subunit alpha	Homo sapiens	103-114	
1834588-3	1991	The evidence that costimulation with PMA can partially overcome the IL2R defect might allow us to localize the cellular defects and rationally design chemotherapeutic agents corrective for these patients" poor p55kDa-IL2R inducibility.	Tetradecanoylphorbol Acetate	37-40	interleukin 2 receptor subunit alpha	Homo sapiens	68-72	
1834588-3	1991	The evidence that costimulation with PMA can partially overcome the IL2R defect might allow us to localize the cellular defects and rationally design chemotherapeutic agents corrective for these patients" poor p55kDa-IL2R inducibility.	Tetradecanoylphorbol Acetate	37-40	interleukin 2 receptor subunit alpha	Homo sapiens	217-221	
1696526-2	1990	We found that CD1+ cells expressed high levels of CD25 antigen upon triggering with specific monoclonal antibodies (mAbs) (anti-CD3, anti-CD2, anti-CD28) in association with low doses of Phorbol-13-myristate-12-acetate (PMA).	Tetradecanoylphorbol Acetate	220-223	interleukin 2 receptor subunit alpha	Homo sapiens	50-54	
2153927-1	1990	We have delineated a positive regulatory element in the interleukin-2 receptor alpha-chain gene (IL-2R alpha) between positions -299 and -243 that can potently activate a heterologous (herpesvirus thymidine kinase [tk]) promoter in phorbol myristate acetate (PMA)-induced Jurkat T cells and is functional when cloned in either orientation.	Tetradecanoylphorbol Acetate	232-257	interleukin 2 receptor subunit alpha	Homo sapiens	97-108	
2153927-1	1990	We have delineated a positive regulatory element in the interleukin-2 receptor alpha-chain gene (IL-2R alpha) between positions -299 and -243 that can potently activate a heterologous (herpesvirus thymidine kinase [tk]) promoter in phorbol myristate acetate (PMA)-induced Jurkat T cells and is functional when cloned in either orientation.	Tetradecanoylphorbol Acetate	259-262	interleukin 2 receptor subunit alpha	Homo sapiens	97-108	
2818583-2	1989	Induction of the expressions of these IL-2R subunits was examined by the protein kinase-C (PK-C) activator (phorbol myristate acetate, PMA) and the calcium ionophore, ionomycine (IM).	Tetradecanoylphorbol Acetate	108-133	interleukin 2 receptor subunit alpha	Homo sapiens	38-43	
2818583-2	1989	Induction of the expressions of these IL-2R subunits was examined by the protein kinase-C (PK-C) activator (phorbol myristate acetate, PMA) and the calcium ionophore, ionomycine (IM).	Tetradecanoylphorbol Acetate	135-138	interleukin 2 receptor subunit alpha	Homo sapiens	38-43	
2548081-3	1989	Identical results were obtained with the human natural killer-like cell line YT, which can be induced to express the interleukin-2 receptor alpha subunit in response to interleukin-1, cyclic AMP, or phorbol 12-myristate 13-acetate.	Tetradecanoylphorbol Acetate	199-230	interleukin 2 receptor subunit alpha	Homo sapiens	117-145	
1974593-3	1990	The ability of the phorbol ester, phorbol 12-myristate 13-acetate (PMA), and the calcium ionophore, A23187, in co-stimulation with PHA, to enhance the IL-2 secretion, IL-2R expression and 3H thymidine incorporation were studied in the PBMC of colorectal cancer patients.	Tetradecanoylphorbol Acetate	34-65	interleukin 2 receptor subunit alpha	Homo sapiens	167-172	
1974593-7	1990	A23187 is known to be effective in elevating cytosolic free Ca2+ and PMA is regarded as an activator of protein kinase C. Therefore, we may conclude that the impairment of IL-2 production and IL-2R expression in PHA-stimulated cultures is mainly due to failure of the free Ca2+ release which can be repaired by A23187.	Tetradecanoylphorbol Acetate	69-72	interleukin 2 receptor subunit alpha	Homo sapiens	192-197	
2210911-5	1990	Northern blot hybridization with a human IL-2R and an IL-2 cDNA showed that bryostatin 1 (bryo 1), like the phorbol ester, PMA, activates the IL-2R gene.	Tetradecanoylphorbol Acetate	123-126	interleukin 2 receptor subunit alpha	Homo sapiens	142-147	
2533503-6	1989	Phorbol myristate acetate (PMA) induces Tac antigen expression in RASF but does not lead to proliferation.	Tetradecanoylphorbol Acetate	0-25	interleukin 2 receptor subunit alpha	Homo sapiens	40-51	
2533503-6	1989	Phorbol myristate acetate (PMA) induces Tac antigen expression in RASF but does not lead to proliferation.	Tetradecanoylphorbol Acetate	27-30	interleukin 2 receptor subunit alpha	Homo sapiens	40-51	
2474594-2	1989	Treatment with PMA or OAG caused down-regulation of the TCR-CD3 complex, but only PMA, in combination with ionomycin, was capable of stimulating IL-2R expression and proliferation.	Tetradecanoylphorbol Acetate	82-85	interleukin 2 receptor subunit alpha	Homo sapiens	145-150	
2785992-3	1989	Despite the presence of cycloheximide or anisomycin at concentrations sufficient to block greater than 97% of cellular protein synthesis, phytohemagglutinin and phorbol 12-myristate 13-acetate effectively induced the expression of the IL-2R alpha gene as measured at the mRNA level.	Tetradecanoylphorbol Acetate	161-192	interleukin 2 receptor subunit alpha	Homo sapiens	235-246	
2544432-1	1989	Monoclonal antibodies (mAb) against CD3 or CD28 in conjunction with the tumor promoter phorbol 12-myristate 13-acetate (PMA) induce interleukin 2 receptor (IL2R) expression, IL2 production and proliferation in resting T cells.	Tetradecanoylphorbol Acetate	87-118	interleukin 2 receptor subunit alpha	Homo sapiens	156-160	
2544432-1	1989	Monoclonal antibodies (mAb) against CD3 or CD28 in conjunction with the tumor promoter phorbol 12-myristate 13-acetate (PMA) induce interleukin 2 receptor (IL2R) expression, IL2 production and proliferation in resting T cells.	Tetradecanoylphorbol Acetate	120-123	interleukin 2 receptor subunit alpha	Homo sapiens	156-160	
3132714-1	1988	Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells.	Tetradecanoylphorbol Acetate	230-261	interleukin 2 receptor subunit alpha	Homo sapiens	81-92	
3264362-5	1988	Following activation in vitro with a series of different stimulatory agents including BCGF, phorbol myristate acetate, and anti-human IgM antibody, cultured HCs increased their capability to shed the IL-2R molecules.	Tetradecanoylphorbol Acetate	92-117	interleukin 2 receptor subunit alpha	Homo sapiens	200-205	
3132714-1	1988	Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells.	Tetradecanoylphorbol Acetate	230-261	interleukin 2 receptor subunit alpha	Homo sapiens	106-110	
3132714-1	1988	Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells.	Tetradecanoylphorbol Acetate	230-261	interleukin 2 receptor subunit alpha	Homo sapiens	133-138	
3132714-1	1988	Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells.	Tetradecanoylphorbol Acetate	263-266	interleukin 2 receptor subunit alpha	Homo sapiens	81-92	
3132714-1	1988	Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells.	Tetradecanoylphorbol Acetate	263-266	interleukin 2 receptor subunit alpha	Homo sapiens	106-110	
3132714-1	1988	Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells.	Tetradecanoylphorbol Acetate	263-266	interleukin 2 receptor subunit alpha	Homo sapiens	133-138	
3123107-4	1987	The results demonstrate that following stimulation with PMA and A23187, purified T cells from elderly subjects demonstrate low levels of IL-2 production, IL-2R expression and cell proliferation.	Tetradecanoylphorbol Acetate	56-59	interleukin 2 receptor subunit alpha	Homo sapiens	154-159	
2822168-4	1987	Stimulation of these pre-T-ALL cells with 12-0-tetradecanoylphorbol-13-acetate (TPA) induced only CD25 (Tac) antigen but no other T cell antigens.	Tetradecanoylphorbol Acetate	80-83	interleukin 2 receptor subunit alpha	Homo sapiens	98-102	
2822168-7	1987	TPA induced the differentiation of the more mature pre-T-ALL cells of this case in vitro, and not only CD25 (Tac) antigen but also CD4 and CD8 antigens appeared on the cell surface.	Tetradecanoylphorbol Acetate	0-3	interleukin 2 receptor subunit alpha	Homo sapiens	103-107	
2424873-7	1986	Surface marker analysis revealed that the expression of CD2 to CD7 antigens (and also CD25) may be modified following incubation of the TLC with TPA or sodium butyrate but not with 5-azacytidine.	Tetradecanoylphorbol Acetate	145-148	interleukin 2 receptor subunit alpha	Homo sapiens	86-90	
3118114-6	1987	Cross-linking of 125I-labeled IL-2 to TPA activated B cell precursor ALL revealed the 55 kD Tac/CD25 protein and an additional protein of 75 kD.	Tetradecanoylphorbol Acetate	38-41	interleukin 2 receptor subunit alpha	Homo sapiens	96-100	
3115657-4	1987	At low concentrations (0.1 microM), A23187 synergized maximally with PMA to induce proliferation, to increase IL-2R mRNA levels and the expression of membrane IL-2R, and to produce a low but sufficient accumulation of IL-2 mRNA and IL-2 secretion.	Tetradecanoylphorbol Acetate	69-72	interleukin 2 receptor subunit alpha	Homo sapiens	110-115	
3115657-4	1987	At low concentrations (0.1 microM), A23187 synergized maximally with PMA to induce proliferation, to increase IL-2R mRNA levels and the expression of membrane IL-2R, and to produce a low but sufficient accumulation of IL-2 mRNA and IL-2 secretion.	Tetradecanoylphorbol Acetate	69-72	interleukin 2 receptor subunit alpha	Homo sapiens	159-164	
3026433-2	1986	After in-vitro stimulation with various agents including TPA, gamma interferon and colony stimulating factor, the purified blast cells of all cases of AML tested (10 of 10) showed high levels (50-90% cells positive) of IL-2R expression.	Tetradecanoylphorbol Acetate	57-60	interleukin 2 receptor subunit alpha	Homo sapiens	219-224	
3115340-3	1987	Cell incubation with phorbol myristate acetate (PMA) increased the expression of B4 antigen and significantly decreased the proportion of My9+ and IL2-R-bearing cells.	Tetradecanoylphorbol Acetate	21-46	interleukin 2 receptor subunit alpha	Homo sapiens	147-152	
3115340-3	1987	Cell incubation with phorbol myristate acetate (PMA) increased the expression of B4 antigen and significantly decreased the proportion of My9+ and IL2-R-bearing cells.	Tetradecanoylphorbol Acetate	48-51	interleukin 2 receptor subunit alpha	Homo sapiens	147-152	
3115340-7	1987	PMA-treated blast cells, however, generated B cell colonies in the presence of rIL2, thus suggesting that PMA could induce functional IL2-R on immature leukemic B cells.	Tetradecanoylphorbol Acetate	0-3	interleukin 2 receptor subunit alpha	Homo sapiens	134-139	
3115340-7	1987	PMA-treated blast cells, however, generated B cell colonies in the presence of rIL2, thus suggesting that PMA could induce functional IL2-R on immature leukemic B cells.	Tetradecanoylphorbol Acetate	106-109	interleukin 2 receptor subunit alpha	Homo sapiens	134-139	
3496927-9	1987	Only cells activated with TPA coexpressed B1 and T1 as well as B5 and IL-2R.	Tetradecanoylphorbol Acetate	26-29	interleukin 2 receptor subunit alpha	Homo sapiens	70-75	
2893506-2	1987	IL-2-R gene expression is induced by pharmacological agents including calcium ions, phorbol esters such as phorbol myristate acetate (PMA) and forskolin (FK), a direct activator of adenylate cyclase.	Tetradecanoylphorbol Acetate	107-132	interleukin 2 receptor subunit alpha	Homo sapiens	0-6	
2893506-2	1987	IL-2-R gene expression is induced by pharmacological agents including calcium ions, phorbol esters such as phorbol myristate acetate (PMA) and forskolin (FK), a direct activator of adenylate cyclase.	Tetradecanoylphorbol Acetate	134-137	interleukin 2 receptor subunit alpha	Homo sapiens	0-6	
3007165-4	1986	These studies show that TPA at a final concentration of 5 ng/ml greatly increased Tac antigen expression on a number of sublines of B17.	Tetradecanoylphorbol Acetate	24-27	interleukin 2 receptor subunit alpha	Homo sapiens	82-93	
3011152-5	1986	Induction of Tac antigen, a putative interleukin 2 (IL 2) receptor, was observed in two cases after cultivation with PMA or with a novel lymphokine, adult T cell leukemia-derived factor (ADF).	Tetradecanoylphorbol Acetate	117-120	interleukin 2 receptor subunit alpha	Homo sapiens	13-24	
6330200-2	1984	We investigated whether cultured acute lymphocytic leukemic T cell lines can be induced to differentiate and express the Tac antigen, a cell surface protein that contains a TCGF-binding site, after exposure to phorbol 12-myristate 13-acetate (PMA) and/or phytohemagglutinin (PHA).	Tetradecanoylphorbol Acetate	210-241	interleukin 2 receptor subunit alpha	Homo sapiens	121-132	
3086629-4	1986	Phorbol 12-myristate 13-acetate (PMA) could induce Tac antigen in all cases.	Tetradecanoylphorbol Acetate	0-31	interleukin 2 receptor subunit alpha	Homo sapiens	51-62	
3086629-4	1986	Phorbol 12-myristate 13-acetate (PMA) could induce Tac antigen in all cases.	Tetradecanoylphorbol Acetate	33-36	interleukin 2 receptor subunit alpha	Homo sapiens	51-62	
20508956-8	2010	Most of the syncytia were viable and expressed CD25 and IL-2 in response to activation by phorbol myristate acetate (PMA) and ionomicyn.	Tetradecanoylphorbol Acetate	90-115	interleukin 2 receptor subunit alpha	Homo sapiens	47-51	
20508956-8	2010	Most of the syncytia were viable and expressed CD25 and IL-2 in response to activation by phorbol myristate acetate (PMA) and ionomicyn.	Tetradecanoylphorbol Acetate	117-120	interleukin 2 receptor subunit alpha	Homo sapiens	47-51	
20846475-2	2010	Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid.	Tetradecanoylphorbol Acetate	126-157	interleukin 2 receptor subunit alpha	Homo sapiens	101-106	
20846475-2	2010	Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid.	Tetradecanoylphorbol Acetate	126-157	interleukin 2 receptor subunit alpha	Homo sapiens	107-111	
20846475-2	2010	Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid.	Tetradecanoylphorbol Acetate	159-162	interleukin 2 receptor subunit alpha	Homo sapiens	101-106	
20846475-2	2010	Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid.	Tetradecanoylphorbol Acetate	159-162	interleukin 2 receptor subunit alpha	Homo sapiens	107-111	
19507195-4	2009	The results showed that PAB dose-dependently suppressed human T lymphocyte proliferation, IL-2 production and CD25 expression induced by co-stimulation of PMA plus ionomycin or of anti-OKT-3 plus anti-CD28.	Tetradecanoylphorbol Acetate	155-158	interleukin 2 receptor subunit alpha	Homo sapiens	110-114