PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17355247-10 2007 Moreover, leptin enhanced the expression of CD69 and CD25 on CD4(+) and CD8(+) cells after stimulation with PMA-ionomycin. Tetradecanoylphorbol Acetate 108-111 interleukin 2 receptor subunit alpha Homo sapiens 53-57 10632964-4 2000 Ovine US caused dose-dependent inhibition of lymphocyte proliferation induced by phorbol myristol acetate (PMA), an activator of protein kinase C. The PHA-induced increase in CD25 expression was inhibited in peripheral blood mononuclear leukocytes (PBML) by OvUS. Tetradecanoylphorbol Acetate 107-110 interleukin 2 receptor subunit alpha Homo sapiens 175-179 10985305-4 2000 Stimulation of these cells with anti-CD28 antibody, and either phorbol 12-myristate 13-acetate (PMA) or anti-CD3, activates signal transduction pathways and results in IL-2 production and IL-2 receptor alpha-chain (CD25) expression. Tetradecanoylphorbol Acetate 63-94 interleukin 2 receptor subunit alpha Homo sapiens 215-219 10985305-4 2000 Stimulation of these cells with anti-CD28 antibody, and either phorbol 12-myristate 13-acetate (PMA) or anti-CD3, activates signal transduction pathways and results in IL-2 production and IL-2 receptor alpha-chain (CD25) expression. Tetradecanoylphorbol Acetate 96-99 interleukin 2 receptor subunit alpha Homo sapiens 215-219 9367861-1 1997 Mobile lipid levels, IL-2R alpha expression and proliferation increased after treatment with PMA and ionomycin. Tetradecanoylphorbol Acetate 93-96 interleukin 2 receptor subunit alpha Homo sapiens 21-32 9682002-6 1998 Lymphocytes which have been exposed to dexamethasone in vitro retained the ability to express CD40L after incubation in medium alone for 48 h. Dexamethasone also inhibited PMA/ionomycin induced IL-2 and IFN-gamma production but not CD25 and CD69 expression. Tetradecanoylphorbol Acetate 172-175 interleukin 2 receptor subunit alpha Homo sapiens 232-236 9583193-4 1998 The anti-CD3 monoclonal antibody-induced expression of interleukin-2 receptor alpha chain (IL-2R/CD25) was significantly suppressed; however, the addition of phorbol 12-myristate 13-acetate or ionomycin caused a remarkable recovery of CD25 expression. Tetradecanoylphorbol Acetate 158-189 interleukin 2 receptor subunit alpha Homo sapiens 91-96 9583193-4 1998 The anti-CD3 monoclonal antibody-induced expression of interleukin-2 receptor alpha chain (IL-2R/CD25) was significantly suppressed; however, the addition of phorbol 12-myristate 13-acetate or ionomycin caused a remarkable recovery of CD25 expression. Tetradecanoylphorbol Acetate 158-189 interleukin 2 receptor subunit alpha Homo sapiens 97-101 9583193-4 1998 The anti-CD3 monoclonal antibody-induced expression of interleukin-2 receptor alpha chain (IL-2R/CD25) was significantly suppressed; however, the addition of phorbol 12-myristate 13-acetate or ionomycin caused a remarkable recovery of CD25 expression. Tetradecanoylphorbol Acetate 158-189 interleukin 2 receptor subunit alpha Homo sapiens 235-239 9367861-2 1997 PMA or ionomycin stimulation alone induced increased IL-2R alpha expression but not proliferation. Tetradecanoylphorbol Acetate 0-3 interleukin 2 receptor subunit alpha Homo sapiens 53-64 9306153-0 1997 Ouabain effects on activated lymphocytes: augmentation of CD25 expression on TPA-stimulated cells and of CD69 on PHA-and TPA-stimulated cells. Tetradecanoylphorbol Acetate 77-80 interleukin 2 receptor subunit alpha Homo sapiens 58-62 9111583-4 1997 When stimulated with anti-CD3 mAb plus phorbol 12-myristate 13-acetate (PMA), CD25 expression was clearly restored in certain cases of ALL. Tetradecanoylphorbol Acetate 39-70 interleukin 2 receptor subunit alpha Homo sapiens 78-82 9111583-4 1997 When stimulated with anti-CD3 mAb plus phorbol 12-myristate 13-acetate (PMA), CD25 expression was clearly restored in certain cases of ALL. Tetradecanoylphorbol Acetate 72-75 interleukin 2 receptor subunit alpha Homo sapiens 78-82 9306153-4 1997 Conversely, cultures activated by TPA and OUA showed an increased expression of CD25. Tetradecanoylphorbol Acetate 34-37 interleukin 2 receptor subunit alpha Homo sapiens 80-84 8633191-4 1996 The expression of the IL-2R by lymphocytes was also resistant to NDGA concentrations that effectively blocked the mitogenic effects of TPA or bryostatin, but could be inhibited by higher concentrations of NDGA (IC50 = 8 microM). Tetradecanoylphorbol Acetate 135-138 interleukin 2 receptor subunit alpha Homo sapiens 22-27 7606799-4 1995 Phorbol ester (PMA), a direct activator of PKC, provoked LHRH production and cell surface expression of CD69 and IL-2R molecules by T cells, but not IL-2 synthesis. Tetradecanoylphorbol Acetate 15-18 interleukin 2 receptor subunit alpha Homo sapiens 113-118 7554401-5 1995 Importantly, the levels of mRNA encoding c-myc, IL-2R alpha, IL-2 and IFN-gamma were markedly decreased in patient lymphocytes stimulated with PMA+ionomycin as compared to control lymphocytes. Tetradecanoylphorbol Acetate 143-146 interleukin 2 receptor subunit alpha Homo sapiens 48-59 7645378-6 1995 However, the addition of phorbol 12-myristate 13-acetate (PMA) caused the significant recovery of CD25 expression. Tetradecanoylphorbol Acetate 25-56 interleukin 2 receptor subunit alpha Homo sapiens 98-102 7645378-6 1995 However, the addition of phorbol 12-myristate 13-acetate (PMA) caused the significant recovery of CD25 expression. Tetradecanoylphorbol Acetate 58-61 interleukin 2 receptor subunit alpha Homo sapiens 98-102 8455941-5 1993 Moreover, whereas both Tax and phorbol 12-myristate 13-acetate (PMA) are able to efficiently induce the binding of NF-kappa B to the IL-2R alpha kappa B site, PMA is functionally inactive. Tetradecanoylphorbol Acetate 31-62 interleukin 2 receptor subunit alpha Homo sapiens 133-144 8258145-6 1993 H47 mAb also enhanced PMA-induced interleukin-2 receptor (IL-2R) expression and IL-2 synthesis, but did not induce a change in intracellular free calcium ([Ca2+]i) of T cells. Tetradecanoylphorbol Acetate 22-25 interleukin 2 receptor subunit alpha Homo sapiens 34-56 8258145-6 1993 H47 mAb also enhanced PMA-induced interleukin-2 receptor (IL-2R) expression and IL-2 synthesis, but did not induce a change in intracellular free calcium ([Ca2+]i) of T cells. Tetradecanoylphorbol Acetate 22-25 interleukin 2 receptor subunit alpha Homo sapiens 58-63 7517692-5 1994 After stimulation by TPA for 3 days, only the appearance of CD25 (Tac antigen) was detected by immunofluorescence and flow cytometry. Tetradecanoylphorbol Acetate 21-24 interleukin 2 receptor subunit alpha Homo sapiens 60-64 7517692-5 1994 After stimulation by TPA for 3 days, only the appearance of CD25 (Tac antigen) was detected by immunofluorescence and flow cytometry. Tetradecanoylphorbol Acetate 21-24 interleukin 2 receptor subunit alpha Homo sapiens 66-77 8206753-4 1994 In T cells stimulated with purified phytohemagglutinin (PHA-p) and 4 beta-phorbol 12-myristate 13-acetate (PMA) addition of DM to the cultures resulted in a 60% reduction in IL-2R alpha and a 30% reduction in IL-2R beta membrane expression compared to T cells cultured in the absence of DM (p < 0.01). Tetradecanoylphorbol Acetate 67-105 interleukin 2 receptor subunit alpha Homo sapiens 174-185 8206753-4 1994 In T cells stimulated with purified phytohemagglutinin (PHA-p) and 4 beta-phorbol 12-myristate 13-acetate (PMA) addition of DM to the cultures resulted in a 60% reduction in IL-2R alpha and a 30% reduction in IL-2R beta membrane expression compared to T cells cultured in the absence of DM (p < 0.01). Tetradecanoylphorbol Acetate 107-110 interleukin 2 receptor subunit alpha Homo sapiens 174-185 8324074-0 1993 Induction of interleukin-2 receptor alpha-chain gene expression by cytochalasin B and 12-O-tetradecanoylphorbol-13-acetate in T lymphocytes. Tetradecanoylphorbol Acetate 86-122 interleukin 2 receptor subunit alpha Homo sapiens 13-41 8324074-4 1993 In this study, we examined the effect of cytochalasin B (CB) plus 12-O-tetradecanoylphorbol-13-acetate (TPA) on expression of IL-2 and IL-2R. Tetradecanoylphorbol Acetate 66-102 interleukin 2 receptor subunit alpha Homo sapiens 135-140 8324074-4 1993 In this study, we examined the effect of cytochalasin B (CB) plus 12-O-tetradecanoylphorbol-13-acetate (TPA) on expression of IL-2 and IL-2R. Tetradecanoylphorbol Acetate 104-107 interleukin 2 receptor subunit alpha Homo sapiens 135-140 8324074-7 1993 Unlike the cells treated individually with CB or TPA, cells treated with CB plus TPA accumulated IL-2R mRNA at all the times examined. Tetradecanoylphorbol Acetate 81-84 interleukin 2 receptor subunit alpha Homo sapiens 97-102 8455941-5 1993 Moreover, whereas both Tax and phorbol 12-myristate 13-acetate (PMA) are able to efficiently induce the binding of NF-kappa B to the IL-2R alpha kappa B site, PMA is functionally inactive. Tetradecanoylphorbol Acetate 64-67 interleukin 2 receptor subunit alpha Homo sapiens 133-144 1394441-3 1992 After stimulation with phytohemagglutinin (PHA) and phorbol myristate acetate (PMA), Tat transfectants with high Tat expression showed diminished expression of interleukin-2 (IL-2) and the interleukin-2 receptor alpha chain (IL-2R) when compared to untransfected Jurkat cells or Jurkat cell lines transfected with the parent control plasmid. Tetradecanoylphorbol Acetate 52-77 interleukin 2 receptor subunit alpha Homo sapiens 225-230 1388136-3 1992 TPA-induced T-cell proliferation, expression of interleukin-2 receptor-alpha subunit (IL-2R alpha) and transferrin receptor, CD3 down-regulation and, lastly, the cytosol-to-membrane PKC translocation (determined by an enzymatic assay or by immunoblotting with a cross-reactive anti-PKC peptide antibody) were all facilitated by ionomycin. Tetradecanoylphorbol Acetate 0-3 interleukin 2 receptor subunit alpha Homo sapiens 86-97 1333455-3 1992 Okadaic acid at up to 4 nM enhanced phorbol myristate acetate (PMA)-induced proliferation and CD25 (IL-2 receptor, p55) expression, although it showed no activation by itself. Tetradecanoylphorbol Acetate 36-61 interleukin 2 receptor subunit alpha Homo sapiens 94-98 1333455-3 1992 Okadaic acid at up to 4 nM enhanced phorbol myristate acetate (PMA)-induced proliferation and CD25 (IL-2 receptor, p55) expression, although it showed no activation by itself. Tetradecanoylphorbol Acetate 36-61 interleukin 2 receptor subunit alpha Homo sapiens 115-118 1588792-0 1992 Phorbol myristate acetate-induced expression of high-affinity interleukin 2 receptors and production of interleukin 2 by human acute lymphoblastic leukemia T cells. Tetradecanoylphorbol Acetate 0-25 interleukin 2 receptor subunit alpha Homo sapiens 62-85 1333455-3 1992 Okadaic acid at up to 4 nM enhanced phorbol myristate acetate (PMA)-induced proliferation and CD25 (IL-2 receptor, p55) expression, although it showed no activation by itself. Tetradecanoylphorbol Acetate 63-66 interleukin 2 receptor subunit alpha Homo sapiens 94-98 1333455-3 1992 Okadaic acid at up to 4 nM enhanced phorbol myristate acetate (PMA)-induced proliferation and CD25 (IL-2 receptor, p55) expression, although it showed no activation by itself. Tetradecanoylphorbol Acetate 63-66 interleukin 2 receptor subunit alpha Homo sapiens 115-118 1588792-1 1992 The effect of phorbol myristate acetate (PMA) on the expression of interleukin 2 receptors (IL-2R), production of IL-2 and IL-2-dependent proliferation of acute lymphoblastic leukemia T cells (T-ALL cells) from 10 patients was studied. Tetradecanoylphorbol Acetate 41-44 interleukin 2 receptor subunit alpha Homo sapiens 67-90 1588792-1 1992 The effect of phorbol myristate acetate (PMA) on the expression of interleukin 2 receptors (IL-2R), production of IL-2 and IL-2-dependent proliferation of acute lymphoblastic leukemia T cells (T-ALL cells) from 10 patients was studied. Tetradecanoylphorbol Acetate 41-44 interleukin 2 receptor subunit alpha Homo sapiens 92-97 1588792-5 1992 We found that PMA induced the expression of both IL-2R alpha and IL-2R beta chains, as well as IL-2 production by T-ALL cells. Tetradecanoylphorbol Acetate 14-17 interleukin 2 receptor subunit alpha Homo sapiens 49-60 1588792-8 1992 In two cases tested high-affinity IL-2R on PMA-treated T-ALL cells could internalize 125I-rIL-2 at 37 degrees C. PMA alone enhanced the spontaneous proliferation of T-ALL cells in three cases, whereas a clear synergy between IL-2 and PMA could be detected in three patients" cells. Tetradecanoylphorbol Acetate 43-46 interleukin 2 receptor subunit alpha Homo sapiens 34-39 1371954-2 1992 Interestingly, LAM exhibited a down-regulatory effect on the accumulation of mRNAs for IL-2, IL-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-2 receptor alpha (IL-2R alpha) in T cells co-stimulated with phytohaemagglutinin-P (PHA) and 4 beta-phorbol-12-myristyl-13-acetate (PMA). Tetradecanoylphorbol Acetate 297-300 interleukin 2 receptor subunit alpha Homo sapiens 183-194 1307243-4 1992 Co-stimulation with PHA + phorbol myristate acetate in the absence of AC restored both proliferation and CD25 expression in the aged. Tetradecanoylphorbol Acetate 26-51 interleukin 2 receptor subunit alpha Homo sapiens 105-109 1309491-2 1992 STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 186-217 interleukin 2 receptor subunit alpha Homo sapiens 87-92 1309491-2 1992 STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 186-217 interleukin 2 receptor subunit alpha Homo sapiens 93-96 1309491-2 1992 STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 219-222 interleukin 2 receptor subunit alpha Homo sapiens 87-92 1309491-2 1992 STPM inhibited IL-2 production and the expression of protein P55 of the IL-2 receptor (IL-2R P55), when Jurkat cells were stimulated by a combination of calcium ionophore A23187 (CaI) + phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 219-222 interleukin 2 receptor subunit alpha Homo sapiens 93-96 1907694-5 1991 Phorbol myristate acetate which is known to be protein kinase C (PKC) activator induced IL-2R on monocytes, and PKC inhibitor, H7, inhibited IFN-gamma-induced IL-2R on monocytes in healthy controls. Tetradecanoylphorbol Acetate 0-25 interleukin 2 receptor subunit alpha Homo sapiens 88-93 2011401-2 1991 Treating JURKAT cells with the phorbol ester tetradecanoyl phorbol acetate (TPA) inhibited their proliferation and induced expression of the gene for the interleukin 2 receptor alpha chain (IL2R-alpha), consistent with previous reports. Tetradecanoylphorbol Acetate 76-79 interleukin 2 receptor subunit alpha Homo sapiens 190-200 2011401-4 1991 In contrast, accumulation of mRNAs for the C-FOS, C-JUN, and EGR-1 genes increased markedly in TPA-treated cells and preceded the induction of IL2R-alpha mRNA. Tetradecanoylphorbol Acetate 95-98 interleukin 2 receptor subunit alpha Homo sapiens 143-153 2011401-7 1991 Despite sustained expression of C-MYC, BCL2, or the combination of these protooncogenes, TPA continued to inhibit JURKAT cell growth and to induce IL2R expression. Tetradecanoylphorbol Acetate 89-92 interleukin 2 receptor subunit alpha Homo sapiens 147-151 2026453-1 1991 The role of phorbol myristate acetate (PMA: a protein kinase-C (PKC) activator) and calcium ionophore A23187 in the induction mechanism of the interleukin 2 receptor (IL2R) on B-cell chronic lymphocytic leukemia (B-CLL) cells was studied. Tetradecanoylphorbol Acetate 12-37 interleukin 2 receptor subunit alpha Homo sapiens 143-165 2026453-1 1991 The role of phorbol myristate acetate (PMA: a protein kinase-C (PKC) activator) and calcium ionophore A23187 in the induction mechanism of the interleukin 2 receptor (IL2R) on B-cell chronic lymphocytic leukemia (B-CLL) cells was studied. Tetradecanoylphorbol Acetate 12-37 interleukin 2 receptor subunit alpha Homo sapiens 167-171 2026453-1 1991 The role of phorbol myristate acetate (PMA: a protein kinase-C (PKC) activator) and calcium ionophore A23187 in the induction mechanism of the interleukin 2 receptor (IL2R) on B-cell chronic lymphocytic leukemia (B-CLL) cells was studied. Tetradecanoylphorbol Acetate 39-42 interleukin 2 receptor subunit alpha Homo sapiens 143-165 2026453-1 1991 The role of phorbol myristate acetate (PMA: a protein kinase-C (PKC) activator) and calcium ionophore A23187 in the induction mechanism of the interleukin 2 receptor (IL2R) on B-cell chronic lymphocytic leukemia (B-CLL) cells was studied. Tetradecanoylphorbol Acetate 39-42 interleukin 2 receptor subunit alpha Homo sapiens 167-171 2026453-4 1991 Radiolabeled IL2 binding assays also demonstrated that PMA induced both high-affinity IL2R (HA-IL2R) and low-affinity IL2R (LA-IL2R) on B-CLL cells, but that A23187 did not. Tetradecanoylphorbol Acetate 55-58 interleukin 2 receptor subunit alpha Homo sapiens 86-90 2026453-4 1991 Radiolabeled IL2 binding assays also demonstrated that PMA induced both high-affinity IL2R (HA-IL2R) and low-affinity IL2R (LA-IL2R) on B-CLL cells, but that A23187 did not. Tetradecanoylphorbol Acetate 55-58 interleukin 2 receptor subunit alpha Homo sapiens 95-99 2026453-4 1991 Radiolabeled IL2 binding assays also demonstrated that PMA induced both high-affinity IL2R (HA-IL2R) and low-affinity IL2R (LA-IL2R) on B-CLL cells, but that A23187 did not. Tetradecanoylphorbol Acetate 55-58 interleukin 2 receptor subunit alpha Homo sapiens 95-99 2026453-4 1991 Radiolabeled IL2 binding assays also demonstrated that PMA induced both high-affinity IL2R (HA-IL2R) and low-affinity IL2R (LA-IL2R) on B-CLL cells, but that A23187 did not. Tetradecanoylphorbol Acetate 55-58 interleukin 2 receptor subunit alpha Homo sapiens 95-99 2026453-5 1991 After treatment with PMA, three of five cases did not respond to IL2 even though they expressed HA-IL2R, suggesting impaired signal transduction. Tetradecanoylphorbol Acetate 21-24 interleukin 2 receptor subunit alpha Homo sapiens 99-103 1834588-3 1991 The evidence that costimulation with PMA can partially overcome the IL2R defect might allow us to localize the cellular defects and rationally design chemotherapeutic agents corrective for these patients" poor p55kDa-IL2R inducibility. Tetradecanoylphorbol Acetate 37-40 interleukin 2 receptor subunit alpha Homo sapiens 68-72 1834588-3 1991 The evidence that costimulation with PMA can partially overcome the IL2R defect might allow us to localize the cellular defects and rationally design chemotherapeutic agents corrective for these patients" poor p55kDa-IL2R inducibility. Tetradecanoylphorbol Acetate 37-40 interleukin 2 receptor subunit alpha Homo sapiens 217-221 1974593-3 1990 The ability of the phorbol ester, phorbol 12-myristate 13-acetate (PMA), and the calcium ionophore, A23187, in co-stimulation with PHA, to enhance the IL-2 secretion, IL-2R expression and 3H thymidine incorporation were studied in the PBMC of colorectal cancer patients. Tetradecanoylphorbol Acetate 34-65 interleukin 2 receptor subunit alpha Homo sapiens 167-172 1696526-2 1990 We found that CD1+ cells expressed high levels of CD25 antigen upon triggering with specific monoclonal antibodies (mAbs) (anti-CD3, anti-CD2, anti-CD28) in association with low doses of Phorbol-13-myristate-12-acetate (PMA). Tetradecanoylphorbol Acetate 220-223 interleukin 2 receptor subunit alpha Homo sapiens 50-54 1974593-7 1990 A23187 is known to be effective in elevating cytosolic free Ca2+ and PMA is regarded as an activator of protein kinase C. Therefore, we may conclude that the impairment of IL-2 production and IL-2R expression in PHA-stimulated cultures is mainly due to failure of the free Ca2+ release which can be repaired by A23187. Tetradecanoylphorbol Acetate 69-72 interleukin 2 receptor subunit alpha Homo sapiens 192-197 2210911-5 1990 Northern blot hybridization with a human IL-2R and an IL-2 cDNA showed that bryostatin 1 (bryo 1), like the phorbol ester, PMA, activates the IL-2R gene. Tetradecanoylphorbol Acetate 123-126 interleukin 2 receptor subunit alpha Homo sapiens 142-147 2153927-1 1990 We have delineated a positive regulatory element in the interleukin-2 receptor alpha-chain gene (IL-2R alpha) between positions -299 and -243 that can potently activate a heterologous (herpesvirus thymidine kinase [tk]) promoter in phorbol myristate acetate (PMA)-induced Jurkat T cells and is functional when cloned in either orientation. Tetradecanoylphorbol Acetate 232-257 interleukin 2 receptor subunit alpha Homo sapiens 97-108 2153927-1 1990 We have delineated a positive regulatory element in the interleukin-2 receptor alpha-chain gene (IL-2R alpha) between positions -299 and -243 that can potently activate a heterologous (herpesvirus thymidine kinase [tk]) promoter in phorbol myristate acetate (PMA)-induced Jurkat T cells and is functional when cloned in either orientation. Tetradecanoylphorbol Acetate 259-262 interleukin 2 receptor subunit alpha Homo sapiens 97-108 2818583-2 1989 Induction of the expressions of these IL-2R subunits was examined by the protein kinase-C (PK-C) activator (phorbol myristate acetate, PMA) and the calcium ionophore, ionomycine (IM). Tetradecanoylphorbol Acetate 108-133 interleukin 2 receptor subunit alpha Homo sapiens 38-43 2533503-6 1989 Phorbol myristate acetate (PMA) induces Tac antigen expression in RASF but does not lead to proliferation. Tetradecanoylphorbol Acetate 0-25 interleukin 2 receptor subunit alpha Homo sapiens 40-51 2533503-6 1989 Phorbol myristate acetate (PMA) induces Tac antigen expression in RASF but does not lead to proliferation. Tetradecanoylphorbol Acetate 27-30 interleukin 2 receptor subunit alpha Homo sapiens 40-51 2818583-2 1989 Induction of the expressions of these IL-2R subunits was examined by the protein kinase-C (PK-C) activator (phorbol myristate acetate, PMA) and the calcium ionophore, ionomycine (IM). Tetradecanoylphorbol Acetate 135-138 interleukin 2 receptor subunit alpha Homo sapiens 38-43 2548081-3 1989 Identical results were obtained with the human natural killer-like cell line YT, which can be induced to express the interleukin-2 receptor alpha subunit in response to interleukin-1, cyclic AMP, or phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 199-230 interleukin 2 receptor subunit alpha Homo sapiens 117-145 2474594-2 1989 Treatment with PMA or OAG caused down-regulation of the TCR-CD3 complex, but only PMA, in combination with ionomycin, was capable of stimulating IL-2R expression and proliferation. Tetradecanoylphorbol Acetate 82-85 interleukin 2 receptor subunit alpha Homo sapiens 145-150 2785992-3 1989 Despite the presence of cycloheximide or anisomycin at concentrations sufficient to block greater than 97% of cellular protein synthesis, phytohemagglutinin and phorbol 12-myristate 13-acetate effectively induced the expression of the IL-2R alpha gene as measured at the mRNA level. Tetradecanoylphorbol Acetate 161-192 interleukin 2 receptor subunit alpha Homo sapiens 235-246 2544432-1 1989 Monoclonal antibodies (mAb) against CD3 or CD28 in conjunction with the tumor promoter phorbol 12-myristate 13-acetate (PMA) induce interleukin 2 receptor (IL2R) expression, IL2 production and proliferation in resting T cells. Tetradecanoylphorbol Acetate 87-118 interleukin 2 receptor subunit alpha Homo sapiens 156-160 2544432-1 1989 Monoclonal antibodies (mAb) against CD3 or CD28 in conjunction with the tumor promoter phorbol 12-myristate 13-acetate (PMA) induce interleukin 2 receptor (IL2R) expression, IL2 production and proliferation in resting T cells. Tetradecanoylphorbol Acetate 120-123 interleukin 2 receptor subunit alpha Homo sapiens 156-160 2494663-1 1989 We have investigated the biochemical basis for the activation of interleukin 2 receptor alpha-subunit (IL-2R alpha) gene expression in primary human T lymphocytes by a cytokine (tumor necrosis factor alpha), a T-cell mitogen (phorbol 12-myristate 13-acetate), and the transactivator protein (Tax) from the type I human T-cell leukemia virus. Tetradecanoylphorbol Acetate 226-257 interleukin 2 receptor subunit alpha Homo sapiens 103-114 3123107-4 1987 The results demonstrate that following stimulation with PMA and A23187, purified T cells from elderly subjects demonstrate low levels of IL-2 production, IL-2R expression and cell proliferation. Tetradecanoylphorbol Acetate 56-59 interleukin 2 receptor subunit alpha Homo sapiens 154-159 3264362-5 1988 Following activation in vitro with a series of different stimulatory agents including BCGF, phorbol myristate acetate, and anti-human IgM antibody, cultured HCs increased their capability to shed the IL-2R molecules. Tetradecanoylphorbol Acetate 92-117 interleukin 2 receptor subunit alpha Homo sapiens 200-205 2822168-4 1987 Stimulation of these pre-T-ALL cells with 12-0-tetradecanoylphorbol-13-acetate (TPA) induced only CD25 (Tac) antigen but no other T cell antigens. Tetradecanoylphorbol Acetate 80-83 interleukin 2 receptor subunit alpha Homo sapiens 98-102 2822168-7 1987 TPA induced the differentiation of the more mature pre-T-ALL cells of this case in vitro, and not only CD25 (Tac) antigen but also CD4 and CD8 antigens appeared on the cell surface. Tetradecanoylphorbol Acetate 0-3 interleukin 2 receptor subunit alpha Homo sapiens 103-107 3132714-1 1988 Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells. Tetradecanoylphorbol Acetate 230-261 interleukin 2 receptor subunit alpha Homo sapiens 81-92 3132714-1 1988 Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells. Tetradecanoylphorbol Acetate 230-261 interleukin 2 receptor subunit alpha Homo sapiens 106-110 3132714-1 1988 Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells. Tetradecanoylphorbol Acetate 230-261 interleukin 2 receptor subunit alpha Homo sapiens 133-138 3132714-1 1988 Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells. Tetradecanoylphorbol Acetate 263-266 interleukin 2 receptor subunit alpha Homo sapiens 81-92 3132714-1 1988 Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells. Tetradecanoylphorbol Acetate 263-266 interleukin 2 receptor subunit alpha Homo sapiens 106-110 3132714-1 1988 Transfection of deleted forms of the human interleukin 2 receptor alpha subunit (IL-2R alpha; also called CD25 or Tac antigen) gene (IL2RA) promoter revealed a requirement for sequences 3" of base -317 for phytohemagglutinin- and phorbol 12-myristate 13-acetate (PMA)-induced promoter activation in CD4+ Jurkat T cells. Tetradecanoylphorbol Acetate 263-266 interleukin 2 receptor subunit alpha Homo sapiens 133-138 3118114-6 1987 Cross-linking of 125I-labeled IL-2 to TPA activated B cell precursor ALL revealed the 55 kD Tac/CD25 protein and an additional protein of 75 kD. Tetradecanoylphorbol Acetate 38-41 interleukin 2 receptor subunit alpha Homo sapiens 96-100 3115340-3 1987 Cell incubation with phorbol myristate acetate (PMA) increased the expression of B4 antigen and significantly decreased the proportion of My9+ and IL2-R-bearing cells. Tetradecanoylphorbol Acetate 21-46 interleukin 2 receptor subunit alpha Homo sapiens 147-152 3115340-3 1987 Cell incubation with phorbol myristate acetate (PMA) increased the expression of B4 antigen and significantly decreased the proportion of My9+ and IL2-R-bearing cells. Tetradecanoylphorbol Acetate 48-51 interleukin 2 receptor subunit alpha Homo sapiens 147-152 3115340-7 1987 PMA-treated blast cells, however, generated B cell colonies in the presence of rIL2, thus suggesting that PMA could induce functional IL2-R on immature leukemic B cells. Tetradecanoylphorbol Acetate 0-3 interleukin 2 receptor subunit alpha Homo sapiens 134-139 3115340-7 1987 PMA-treated blast cells, however, generated B cell colonies in the presence of rIL2, thus suggesting that PMA could induce functional IL2-R on immature leukemic B cells. Tetradecanoylphorbol Acetate 106-109 interleukin 2 receptor subunit alpha Homo sapiens 134-139 3496927-9 1987 Only cells activated with TPA coexpressed B1 and T1 as well as B5 and IL-2R. Tetradecanoylphorbol Acetate 26-29 interleukin 2 receptor subunit alpha Homo sapiens 70-75 3011152-5 1986 Induction of Tac antigen, a putative interleukin 2 (IL 2) receptor, was observed in two cases after cultivation with PMA or with a novel lymphokine, adult T cell leukemia-derived factor (ADF). Tetradecanoylphorbol Acetate 117-120 interleukin 2 receptor subunit alpha Homo sapiens 13-24 3115657-4 1987 At low concentrations (0.1 microM), A23187 synergized maximally with PMA to induce proliferation, to increase IL-2R mRNA levels and the expression of membrane IL-2R, and to produce a low but sufficient accumulation of IL-2 mRNA and IL-2 secretion. Tetradecanoylphorbol Acetate 69-72 interleukin 2 receptor subunit alpha Homo sapiens 110-115 3115657-4 1987 At low concentrations (0.1 microM), A23187 synergized maximally with PMA to induce proliferation, to increase IL-2R mRNA levels and the expression of membrane IL-2R, and to produce a low but sufficient accumulation of IL-2 mRNA and IL-2 secretion. Tetradecanoylphorbol Acetate 69-72 interleukin 2 receptor subunit alpha Homo sapiens 159-164 2893506-2 1987 IL-2-R gene expression is induced by pharmacological agents including calcium ions, phorbol esters such as phorbol myristate acetate (PMA) and forskolin (FK), a direct activator of adenylate cyclase. Tetradecanoylphorbol Acetate 107-132 interleukin 2 receptor subunit alpha Homo sapiens 0-6 2893506-2 1987 IL-2-R gene expression is induced by pharmacological agents including calcium ions, phorbol esters such as phorbol myristate acetate (PMA) and forskolin (FK), a direct activator of adenylate cyclase. Tetradecanoylphorbol Acetate 134-137 interleukin 2 receptor subunit alpha Homo sapiens 0-6 3026433-2 1986 After in-vitro stimulation with various agents including TPA, gamma interferon and colony stimulating factor, the purified blast cells of all cases of AML tested (10 of 10) showed high levels (50-90% cells positive) of IL-2R expression. Tetradecanoylphorbol Acetate 57-60 interleukin 2 receptor subunit alpha Homo sapiens 219-224 2424873-7 1986 Surface marker analysis revealed that the expression of CD2 to CD7 antigens (and also CD25) may be modified following incubation of the TLC with TPA or sodium butyrate but not with 5-azacytidine. Tetradecanoylphorbol Acetate 145-148 interleukin 2 receptor subunit alpha Homo sapiens 86-90 6330200-2 1984 We investigated whether cultured acute lymphocytic leukemic T cell lines can be induced to differentiate and express the Tac antigen, a cell surface protein that contains a TCGF-binding site, after exposure to phorbol 12-myristate 13-acetate (PMA) and/or phytohemagglutinin (PHA). Tetradecanoylphorbol Acetate 210-241 interleukin 2 receptor subunit alpha Homo sapiens 121-132 3007165-4 1986 These studies show that TPA at a final concentration of 5 ng/ml greatly increased Tac antigen expression on a number of sublines of B17. Tetradecanoylphorbol Acetate 24-27 interleukin 2 receptor subunit alpha Homo sapiens 82-93 3086629-4 1986 Phorbol 12-myristate 13-acetate (PMA) could induce Tac antigen in all cases. Tetradecanoylphorbol Acetate 0-31 interleukin 2 receptor subunit alpha Homo sapiens 51-62 3086629-4 1986 Phorbol 12-myristate 13-acetate (PMA) could induce Tac antigen in all cases. Tetradecanoylphorbol Acetate 33-36 interleukin 2 receptor subunit alpha Homo sapiens 51-62 20508956-8 2010 Most of the syncytia were viable and expressed CD25 and IL-2 in response to activation by phorbol myristate acetate (PMA) and ionomicyn. Tetradecanoylphorbol Acetate 90-115 interleukin 2 receptor subunit alpha Homo sapiens 47-51 20508956-8 2010 Most of the syncytia were viable and expressed CD25 and IL-2 in response to activation by phorbol myristate acetate (PMA) and ionomicyn. Tetradecanoylphorbol Acetate 117-120 interleukin 2 receptor subunit alpha Homo sapiens 47-51 20846475-2 2010 Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid. Tetradecanoylphorbol Acetate 126-157 interleukin 2 receptor subunit alpha Homo sapiens 101-106 20846475-2 2010 Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid. Tetradecanoylphorbol Acetate 126-157 interleukin 2 receptor subunit alpha Homo sapiens 107-111 20846475-2 2010 Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid. Tetradecanoylphorbol Acetate 159-162 interleukin 2 receptor subunit alpha Homo sapiens 101-106 20846475-2 2010 Transfection of cells with an antisense PKCbeta construct (as-PKCbeta-pREP3) significantly increased IL-2R/CD25 expression in phorbol 12-myristate 13-acetate (PMA)-stimulated as-PKCbeta-pREP3 transfectants, in contrast to Jurkat cells transfected with a control as-PKCalpha-pREP3 plasmid. Tetradecanoylphorbol Acetate 159-162 interleukin 2 receptor subunit alpha Homo sapiens 107-111 19507195-4 2009 The results showed that PAB dose-dependently suppressed human T lymphocyte proliferation, IL-2 production and CD25 expression induced by co-stimulation of PMA plus ionomycin or of anti-OKT-3 plus anti-CD28. Tetradecanoylphorbol Acetate 155-158 interleukin 2 receptor subunit alpha Homo sapiens 110-114