PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24464785-5	2014	The dependency on RasGRP1 was associated with a diminished response to the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	104-140	RAS guanyl releasing protein 1	Mus musculus	18-25	
24464785-5	2014	The dependency on RasGRP1 was associated with a diminished response to the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).	Tetradecanoylphorbol Acetate	142-145	RAS guanyl releasing protein 1	Mus musculus	18-25	
24464785-7	2014	Using a keratinocyte cell line that carries a ras oncogenic mutation, we also demonstrated that RasGRP1 could further activate Ras in response to TPA.	Tetradecanoylphorbol Acetate	146-149	RAS guanyl releasing protein 1	Mus musculus	96-103	
20308057-0	2010	RasGRP1 is essential for ras activation by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in epidermal keratinocytes.	Tetradecanoylphorbol Acetate	62-98	RAS guanyl releasing protein 1	Mus musculus	0-7	
16546974-8	2006	In addition, TPA led to a concentration-dependent down-regulation of RasGRP1, whereas bryostatin 1 failed to induce full RasGRP1 down-regulation.	Tetradecanoylphorbol Acetate	13-16	RAS guanyl releasing protein 1	Mus musculus	69-76	
20308057-2	2010	Recently, we demonstrated a role for RasGRP1 in skin carcinogenesis and suggested its participation in the action of tumor-promoting phorbol esters like 12-O-tetradecanoylphorbol-13-acetate (TPA) on Ras pathways in epidermal cells.	Tetradecanoylphorbol Acetate	153-189	RAS guanyl releasing protein 1	Mus musculus	37-44	
20308057-2	2010	Recently, we demonstrated a role for RasGRP1 in skin carcinogenesis and suggested its participation in the action of tumor-promoting phorbol esters like 12-O-tetradecanoylphorbol-13-acetate (TPA) on Ras pathways in epidermal cells.	Tetradecanoylphorbol Acetate	191-194	RAS guanyl releasing protein 1	Mus musculus	37-44	
20308057-6	2010	Furthermore, small hairpin RNA-induced silencing of RasGRP1 abrogated the effect of TPA on Ras.	Tetradecanoylphorbol Acetate	84-87	RAS guanyl releasing protein 1	Mus musculus	52-59	
20308057-7	2010	Analysis of Ras isoforms showed that both H-Ras and N-Ras depended on RasGRP1 for activation by TPA, whereas activation of K-Ras could not be detected.	Tetradecanoylphorbol Acetate	96-99	RAS guanyl releasing protein 1	Mus musculus	70-77	
20308057-9	2010	Notably, TPA-induced phosphorylation of JNK2, but not JNK1, was reduced by RasGRP1 depletion.	Tetradecanoylphorbol Acetate	9-12	RAS guanyl releasing protein 1	Mus musculus	75-82	
20308057-10	2010	These data identify RasGRP1 as a critical molecule in the activation of Ras by TPA in primary mouse keratinocytes and suggest JNK2 as one of the relevant downstream targets.	Tetradecanoylphorbol Acetate	79-82	RAS guanyl releasing protein 1	Mus musculus	20-27	
17210708-2	2007	We have recently shown expression of RasGRP1 in the epidermal keratinocytes where it can mediate Ras activation in response to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate, a well-known mouse skin tumor promoter.	Tetradecanoylphorbol Acetate	145-181	RAS guanyl releasing protein 1	Mus musculus	37-44	
17974959-7	2007	In primary keratinocytes isolated from K5.RasGRP1 mice, TPA stimulation induced higher levels of Ras activation compared with the levels measured in the wild-type cells, indicating that constitutive overexpression of RasGRP1 in epidermal cells leads to elevated biochemical activation of endogenous Ras in response to TPA.	Tetradecanoylphorbol Acetate	56-59	RAS guanyl releasing protein 1	Mus musculus	42-49	
17974959-7	2007	In primary keratinocytes isolated from K5.RasGRP1 mice, TPA stimulation induced higher levels of Ras activation compared with the levels measured in the wild-type cells, indicating that constitutive overexpression of RasGRP1 in epidermal cells leads to elevated biochemical activation of endogenous Ras in response to TPA.	Tetradecanoylphorbol Acetate	56-59	RAS guanyl releasing protein 1	Mus musculus	217-224	
17974959-7	2007	In primary keratinocytes isolated from K5.RasGRP1 mice, TPA stimulation induced higher levels of Ras activation compared with the levels measured in the wild-type cells, indicating that constitutive overexpression of RasGRP1 in epidermal cells leads to elevated biochemical activation of endogenous Ras in response to TPA.	Tetradecanoylphorbol Acetate	318-321	RAS guanyl releasing protein 1	Mus musculus	217-224	
16546974-0	2006	Differential effects of bryostatin 1 and 12-O-tetradecanoylphorbol-13-acetate on the regulation and activation of RasGRP1 in mouse epidermal keratinocytes.	Tetradecanoylphorbol Acetate	41-77	RAS guanyl releasing protein 1	Mus musculus	114-121	
16546974-5	2006	We recently reported that the novel DAG receptor RasGRP1 is expressed in mouse keratinocytes and mediates TPA-induced Ras activation.	Tetradecanoylphorbol Acetate	106-109	RAS guanyl releasing protein 1	Mus musculus	49-56	
16546974-7	2006	We found that whereas TPA induced translocation of RasGRP1 to both the plasma and internal membranes of the keratinocytes, bryostatin 1 recruited RasGRP1 only to internal membranes and the nuclear envelope.	Tetradecanoylphorbol Acetate	22-25	RAS guanyl releasing protein 1	Mus musculus	51-58	
14532295-6	2003	TPA treatment further elevated this Ras activation in a PKC-independent manner and induced the translocation and down-regulation of RasGRP1.	Tetradecanoylphorbol Acetate	0-3	RAS guanyl releasing protein 1	Mus musculus	132-139