PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10848972-9	2000	These results indicate that the region (-70 to -30) of the human ADM gene containing multiple AP-2 binding sites is responsible for TPA-induced adrenomedullin expression in THP-1 cells.	Tetradecanoylphorbol Acetate	132-135	transcription factor AP-2 alpha	Homo sapiens	94-98	
11560779-7	2001	The contributions of these binding sites and the roles of the transcription factors Egr-1, AP-2, and Sp1 in the activation of hMnSOD transcription by TPA were investigated by site-directed mutation analysis, Western blotting, and overexpression of transcription factors.	Tetradecanoylphorbol Acetate	150-153	transcription factor AP-2 alpha	Homo sapiens	91-95	
11725057-7	1995	Both the AP-1/AP-2/SP-1 dyad protein binding region and, to a lesser extent, the YY1 tandem-repeat cluster conferred responsiveness to TPA when placed upstream of a heterologous promoter in transient expression assays.	Tetradecanoylphorbol Acetate	135-138	transcription factor AP-2 alpha	Homo sapiens	14-18	
8988173-5	1997	In a search for cellular factors that could activate p21 during phorbol ester (TPA)-induced differentiation, we identified AP2 as a regulator of p21 expression.	Tetradecanoylphorbol Acetate	79-82	transcription factor AP-2 alpha	Homo sapiens	123-126	
8621697-0	1996	Activation of epidermal growth factor receptor gene transcription by phorbol 12-myristate 13-acetate is mediated by activator protein 2.	Tetradecanoylphorbol Acetate	69-100	transcription factor AP-2 alpha	Homo sapiens	116-135	
9138088-7	1997	Conversely, the DNA-binding of the transcription factor AP-2 was slightly reduced by TPA-induced HL-60 differentiation but unchanged during granulocyte differentiation.	Tetradecanoylphorbol Acetate	85-88	transcription factor AP-2 alpha	Homo sapiens	56-60	
8123590-7	1994	In addition, TPA-mediated induction of AP-2 DNA binding activity to the NPY promoter was not dependent on increased AP-2 mRNA expression.	Tetradecanoylphorbol Acetate	13-16	transcription factor AP-2 alpha	Homo sapiens	39-43	
7907090-4	1994	Four TPA-responsive DNA regions were identified, each containing a potential TPA-responsive enhancer sequence: 1) -677/-340 an AP3-like sequence; 2) -290/278 a TPA-response element (TRE); 3) -227/-175 an NF kappa B-like sequence; 4) -105/-38 an AP2-like sequence.	Tetradecanoylphorbol Acetate	5-8	transcription factor AP-2 alpha	Homo sapiens	245-248	
21499124-6	2011	Binding activity to ULBP1 promoter region of AP-2alpha, which suggested as suppressor of expression of ULBP1, was decreased by treatment with EGFR inhibitors, and restored by pretreatment with phorbol 12-myristate 13-acetate in A549 and SW-900.	Tetradecanoylphorbol Acetate	193-224	transcription factor AP-2 alpha	Homo sapiens	45-54	
1634545-0	1992	Interaction of AP-1-, AP-2-, and Sp1-like proteins with two distinct sites in the upstream regulatory region of the plasminogen activator inhibitor-1 gene mediates the phorbol 12-myristate 13-acetate response.	Tetradecanoylphorbol Acetate	168-199	transcription factor AP-2 alpha	Homo sapiens	22-26	
2482225-4	1989	AP-2 also has been proposed to confer TPA and cAMP inducibility on promoters/enhancers containing AP-2-binding sites.	Tetradecanoylphorbol Acetate	38-41	transcription factor AP-2 alpha	Homo sapiens	0-4	
2482225-4	1989	AP-2 also has been proposed to confer TPA and cAMP inducibility on promoters/enhancers containing AP-2-binding sites.	Tetradecanoylphorbol Acetate	38-41	transcription factor AP-2 alpha	Homo sapiens	98-102	
2482225-7	1989	In fact, AP-2 mRNA is repressed by both TPA and the calcium ionophore A23187 through a delayed response.	Tetradecanoylphorbol Acetate	40-43	transcription factor AP-2 alpha	Homo sapiens	9-13	
2482225-8	1989	These data suggest that the AP-2-binding site-mediated cAMP and TPA responses are not regulated at the level of AP-2 expression but, rather, achieved either by post-translational changes in AP-2 or in conjunction with another protein.	Tetradecanoylphorbol Acetate	64-67	transcription factor AP-2 alpha	Homo sapiens	28-32	
20564234-7	2010	We demonstrated that phorbol 12-myristate 13-acetate (PMA) treatment of the airway epithelial cell line NCI-H292 increases MUC8 gene and AP2 alpha expression.	Tetradecanoylphorbol Acetate	21-52	transcription factor AP-2 alpha	Homo sapiens	137-146	
20564234-7	2010	We demonstrated that phorbol 12-myristate 13-acetate (PMA) treatment of the airway epithelial cell line NCI-H292 increases MUC8 gene and AP2 alpha expression.	Tetradecanoylphorbol Acetate	54-57	transcription factor AP-2 alpha	Homo sapiens	137-146	
20564234-15	2010	From these results, we concluded that PMA induces MUC8 gene expression through a mechanism involving PKC, ERK1/2, and AP2 alpha activation in human airway epithelial cells.	Tetradecanoylphorbol Acetate	38-41	transcription factor AP-2 alpha	Homo sapiens	118-127	
19472186-3	2009	Treatment with both TPA and TNFalpha decreased mRNA levels of PPARgamma, aP2, LPL and adiponectin.	Tetradecanoylphorbol Acetate	20-23	transcription factor AP-2 alpha	Homo sapiens	73-76