PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20564234-7 2010 We demonstrated that phorbol 12-myristate 13-acetate (PMA) treatment of the airway epithelial cell line NCI-H292 increases MUC8 gene and AP2 alpha expression. Tetradecanoylphorbol Acetate 21-52 transcription factor AP-2 alpha Homo sapiens 137-146 21499124-6 2011 Binding activity to ULBP1 promoter region of AP-2alpha, which suggested as suppressor of expression of ULBP1, was decreased by treatment with EGFR inhibitors, and restored by pretreatment with phorbol 12-myristate 13-acetate in A549 and SW-900. Tetradecanoylphorbol Acetate 193-224 transcription factor AP-2 alpha Homo sapiens 45-54 20564234-7 2010 We demonstrated that phorbol 12-myristate 13-acetate (PMA) treatment of the airway epithelial cell line NCI-H292 increases MUC8 gene and AP2 alpha expression. Tetradecanoylphorbol Acetate 54-57 transcription factor AP-2 alpha Homo sapiens 137-146 20564234-15 2010 From these results, we concluded that PMA induces MUC8 gene expression through a mechanism involving PKC, ERK1/2, and AP2 alpha activation in human airway epithelial cells. Tetradecanoylphorbol Acetate 38-41 transcription factor AP-2 alpha Homo sapiens 118-127 19472186-3 2009 Treatment with both TPA and TNFalpha decreased mRNA levels of PPARgamma, aP2, LPL and adiponectin. Tetradecanoylphorbol Acetate 20-23 transcription factor AP-2 alpha Homo sapiens 73-76 10848972-9 2000 These results indicate that the region (-70 to -30) of the human ADM gene containing multiple AP-2 binding sites is responsible for TPA-induced adrenomedullin expression in THP-1 cells. Tetradecanoylphorbol Acetate 132-135 transcription factor AP-2 alpha Homo sapiens 94-98 11560779-7 2001 The contributions of these binding sites and the roles of the transcription factors Egr-1, AP-2, and Sp1 in the activation of hMnSOD transcription by TPA were investigated by site-directed mutation analysis, Western blotting, and overexpression of transcription factors. Tetradecanoylphorbol Acetate 150-153 transcription factor AP-2 alpha Homo sapiens 91-95 7907090-4 1994 Four TPA-responsive DNA regions were identified, each containing a potential TPA-responsive enhancer sequence: 1) -677/-340 an AP3-like sequence; 2) -290/278 a TPA-response element (TRE); 3) -227/-175 an NF kappa B-like sequence; 4) -105/-38 an AP2-like sequence. Tetradecanoylphorbol Acetate 5-8 transcription factor AP-2 alpha Homo sapiens 245-248 9138088-7 1997 Conversely, the DNA-binding of the transcription factor AP-2 was slightly reduced by TPA-induced HL-60 differentiation but unchanged during granulocyte differentiation. Tetradecanoylphorbol Acetate 85-88 transcription factor AP-2 alpha Homo sapiens 56-60 8621697-0 1996 Activation of epidermal growth factor receptor gene transcription by phorbol 12-myristate 13-acetate is mediated by activator protein 2. Tetradecanoylphorbol Acetate 69-100 transcription factor AP-2 alpha Homo sapiens 116-135 11725057-7 1995 Both the AP-1/AP-2/SP-1 dyad protein binding region and, to a lesser extent, the YY1 tandem-repeat cluster conferred responsiveness to TPA when placed upstream of a heterologous promoter in transient expression assays. Tetradecanoylphorbol Acetate 135-138 transcription factor AP-2 alpha Homo sapiens 14-18 8988173-5 1997 In a search for cellular factors that could activate p21 during phorbol ester (TPA)-induced differentiation, we identified AP2 as a regulator of p21 expression. Tetradecanoylphorbol Acetate 79-82 transcription factor AP-2 alpha Homo sapiens 123-126 2482225-4 1989 AP-2 also has been proposed to confer TPA and cAMP inducibility on promoters/enhancers containing AP-2-binding sites. Tetradecanoylphorbol Acetate 38-41 transcription factor AP-2 alpha Homo sapiens 0-4 8123590-7 1994 In addition, TPA-mediated induction of AP-2 DNA binding activity to the NPY promoter was not dependent on increased AP-2 mRNA expression. Tetradecanoylphorbol Acetate 13-16 transcription factor AP-2 alpha Homo sapiens 39-43 1634545-0 1992 Interaction of AP-1-, AP-2-, and Sp1-like proteins with two distinct sites in the upstream regulatory region of the plasminogen activator inhibitor-1 gene mediates the phorbol 12-myristate 13-acetate response. Tetradecanoylphorbol Acetate 168-199 transcription factor AP-2 alpha Homo sapiens 22-26 2482225-4 1989 AP-2 also has been proposed to confer TPA and cAMP inducibility on promoters/enhancers containing AP-2-binding sites. Tetradecanoylphorbol Acetate 38-41 transcription factor AP-2 alpha Homo sapiens 98-102 2482225-7 1989 In fact, AP-2 mRNA is repressed by both TPA and the calcium ionophore A23187 through a delayed response. Tetradecanoylphorbol Acetate 40-43 transcription factor AP-2 alpha Homo sapiens 9-13 2482225-8 1989 These data suggest that the AP-2-binding site-mediated cAMP and TPA responses are not regulated at the level of AP-2 expression but, rather, achieved either by post-translational changes in AP-2 or in conjunction with another protein. Tetradecanoylphorbol Acetate 64-67 transcription factor AP-2 alpha Homo sapiens 28-32