PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9600114-0 1997 12-O-tetradecanoylphorbol-13-acetate (TPA) downregulates expression of CD30 in erythroleukemia cell line K562. Tetradecanoylphorbol Acetate 0-36 TNF receptor superfamily member 8 Homo sapiens 71-75 11120787-3 2000 In this report, it is demonstrated that PMA-induced CD30 cleavage from Karpas 299 cells was mediated by a membrane-anchored metalloproteinase which was active on intact cells following 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate extraction of membrane preparations. Tetradecanoylphorbol Acetate 40-43 TNF receptor superfamily member 8 Homo sapiens 52-56 9600114-0 1997 12-O-tetradecanoylphorbol-13-acetate (TPA) downregulates expression of CD30 in erythroleukemia cell line K562. Tetradecanoylphorbol Acetate 38-41 TNF receptor superfamily member 8 Homo sapiens 71-75 9600114-3 1997 In this study, modulation of the CD30 molecule was investigated by the treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 86-123 TNF receptor superfamily member 8 Homo sapiens 33-37 9600114-3 1997 In this study, modulation of the CD30 molecule was investigated by the treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 125-128 TNF receptor superfamily member 8 Homo sapiens 33-37 9600114-4 1997 When cultures were supplemented with TPA, CD30 transcript was downregulated in a dose- and time-dependent manner in the erythroleukemia cell line K562. Tetradecanoylphorbol Acetate 37-40 TNF receptor superfamily member 8 Homo sapiens 42-46 9600114-6 1997 This consecutive reduction of both the transcript and proteins suggests that TPA directly inhibits the transcriptional step of CD30, and subsequently CD30 molecules would decrease on the cell surface. Tetradecanoylphorbol Acetate 77-80 TNF receptor superfamily member 8 Homo sapiens 127-131 9600114-6 1997 This consecutive reduction of both the transcript and proteins suggests that TPA directly inhibits the transcriptional step of CD30, and subsequently CD30 molecules would decrease on the cell surface. Tetradecanoylphorbol Acetate 77-80 TNF receptor superfamily member 8 Homo sapiens 150-154 9600114-8 1997 The addition of H-7 recovered the inhibitory effect of TPA, indicating that PKC is involved in the transcription of CD30. Tetradecanoylphorbol Acetate 55-58 TNF receptor superfamily member 8 Homo sapiens 116-120 9600114-9 1997 When either 2 micrograms/ml actinomycin D or 20 micrograms/ml cycloheximide was added simultaneously with TPA to the culture, the repressive effect of TPA on CD30 was abolished. Tetradecanoylphorbol Acetate 106-109 TNF receptor superfamily member 8 Homo sapiens 158-162 9600114-9 1997 When either 2 micrograms/ml actinomycin D or 20 micrograms/ml cycloheximide was added simultaneously with TPA to the culture, the repressive effect of TPA on CD30 was abolished. Tetradecanoylphorbol Acetate 151-154 TNF receptor superfamily member 8 Homo sapiens 158-162 1913689-2 1991 The aim of this study was to investigate the in vitro effects of 12-O-tetradecanoylphorbol-13-acetate used as a differentiation inducer on the CD30, t(5;6)(q35;p21) DEL cell line, taken to be a reliable representative of the human malignant histiocytosis cell line. Tetradecanoylphorbol Acetate 65-101 TNF receptor superfamily member 8 Homo sapiens 143-147 8200037-3 1994 In the present report, we describe a CD30 mAb, termed BY88, that was capable of inducing, in a short-term assay, a strong proliferation of the T cell clone DS6 when added in combination with IL2 or phorbol myristate acetate. Tetradecanoylphorbol Acetate 198-223 TNF receptor superfamily member 8 Homo sapiens 37-41 8255104-11 1993 Cells exposed to phorbol myristate acetate (PMA) had increased expression of CD11a, CD11b, CD18, CD45RO, and HLA-DR, whereas expression of CD15 and CD30 was markedly decreased. Tetradecanoylphorbol Acetate 17-42 TNF receptor superfamily member 8 Homo sapiens 148-152 8839832-0 1996 A variant CD30 protein lacking extracellular and transmembrane domains is induced in HL-60 by tetradecanoylphorbol acetate and is expressed in alveolar macrophages. Tetradecanoylphorbol Acetate 94-122 TNF receptor superfamily member 8 Homo sapiens 10-14 8839832-1 1996 We identified and cloned cDNAs for two novel CD30 mRNAs of 2.3 kb that are induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in the human myeloid leukemia cell line HL-60. Tetradecanoylphorbol Acetate 86-122 TNF receptor superfamily member 8 Homo sapiens 45-49 8839832-1 1996 We identified and cloned cDNAs for two novel CD30 mRNAs of 2.3 kb that are induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in the human myeloid leukemia cell line HL-60. Tetradecanoylphorbol Acetate 124-127 TNF receptor superfamily member 8 Homo sapiens 45-49 8839832-7 1996 Northern blots detected the expression of CD30v transcripts only in the lung and the TPA-stimulated HL-60 cell line. Tetradecanoylphorbol Acetate 85-88 TNF receptor superfamily member 8 Homo sapiens 42-46 8839832-9 1996 Immunoblotting analysis with HCD30C1, a rabbit polyclonal antibody raised against the cytoplasmic domain of CD30 protein, detected proteins with an apparent Mr 25 kD expressed in TPA-stimulated HL-60 and COS-7 cells that were transfected with both types of CD30v cDNAs. Tetradecanoylphorbol Acetate 179-182 TNF receptor superfamily member 8 Homo sapiens 30-34 8839832-9 1996 Immunoblotting analysis with HCD30C1, a rabbit polyclonal antibody raised against the cytoplasmic domain of CD30 protein, detected proteins with an apparent Mr 25 kD expressed in TPA-stimulated HL-60 and COS-7 cells that were transfected with both types of CD30v cDNAs. Tetradecanoylphorbol Acetate 179-182 TNF receptor superfamily member 8 Homo sapiens 257-262 2153049-5 1990 This is in contrast to a rapid decrease in the expression of two other H-RS-cell-associated antigens, CD30 and 2H9, in all 12-O-tetradecanoyl phorbol-13-acetate-treated H-RS cells. Tetradecanoylphorbol Acetate 123-160 TNF receptor superfamily member 8 Homo sapiens 102-106