PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9678170-7 1998 Upon concurrent stimulation of EL4.IL-2 cells with phorbol 12-myristate-13-acetate, seven of the eight strains displayed significant enhancement of IL-2 and IL-5 production, with S. thermophilus being most effective. Tetradecanoylphorbol Acetate 51-82 interleukin 5 Mus musculus 157-161 17430547-6 2007 Similarly, phorbol myristate acetate (PMA)- and ionomycin-stimulated intracellular cytokine expression of IL-4, IL-5, and GM-CSF in splenic CD4(+) T cells was inversely correlated with serum CRI and directly correlated with spleen size. Tetradecanoylphorbol Acetate 11-36 interleukin 5 Mus musculus 112-116 17430547-6 2007 Similarly, phorbol myristate acetate (PMA)- and ionomycin-stimulated intracellular cytokine expression of IL-4, IL-5, and GM-CSF in splenic CD4(+) T cells was inversely correlated with serum CRI and directly correlated with spleen size. Tetradecanoylphorbol Acetate 38-41 interleukin 5 Mus musculus 112-116 15355467-8 2004 Nonspecific stimulus with calcium ionophore and phorbol-myristate-acetate of BM CD34(+) cells caused release of IL-5, IL-3 and GM-CSF. Tetradecanoylphorbol Acetate 48-73 interleukin 5 Mus musculus 112-116 11792635-6 2002 Eosinophils isolated from the lungs and stimulated with phorbol 12-myristate 13-acetate and/or A-23187 released IL-5. Tetradecanoylphorbol Acetate 56-87 interleukin 5 Mus musculus 112-116 23463138-5 2013 Fluorescence activated cell sorting results indicated that Th cells were the main source of IL-5 in the T cell population after phorbol 12-myristate 13-acetate and ionomycin stimulation. Tetradecanoylphorbol Acetate 128-159 interleukin 5 Mus musculus 92-96 22920671-2 2012 We found that brazilin inhibited the mRNA and protein expression of interleukin (IL)-4 and IL-5 induced by phorbol myristate acetate (PMA) and cAMP in EL-4 T cells in a dose-dependent manner. Tetradecanoylphorbol Acetate 107-132 interleukin 5 Mus musculus 91-95 22920671-2 2012 We found that brazilin inhibited the mRNA and protein expression of interleukin (IL)-4 and IL-5 induced by phorbol myristate acetate (PMA) and cAMP in EL-4 T cells in a dose-dependent manner. Tetradecanoylphorbol Acetate 134-137 interleukin 5 Mus musculus 91-95 22733205-4 2012 We found that scopoletin significantly inhibited phorbol myristate acetate (PMA)/ionomycin-induced interleukin-4 (IL-4), IL-5, and IL-10 production in EL-4 T cells. Tetradecanoylphorbol Acetate 49-74 interleukin 5 Mus musculus 121-125 22733205-4 2012 We found that scopoletin significantly inhibited phorbol myristate acetate (PMA)/ionomycin-induced interleukin-4 (IL-4), IL-5, and IL-10 production in EL-4 T cells. Tetradecanoylphorbol Acetate 76-79 interleukin 5 Mus musculus 121-125 16373364-4 2006 Transcription of IL-5 reporter gene plasmids could be induced in D10 cells by phorbol myristate acetate/cyclic adenosine monophosphate (PMA/cAMP) stimulation and significantly further enhanced by activation of the mitogen-activated protein (MAP) kinase pathways. Tetradecanoylphorbol Acetate 78-103 interleukin 5 Mus musculus 17-21 16373364-4 2006 Transcription of IL-5 reporter gene plasmids could be induced in D10 cells by phorbol myristate acetate/cyclic adenosine monophosphate (PMA/cAMP) stimulation and significantly further enhanced by activation of the mitogen-activated protein (MAP) kinase pathways. Tetradecanoylphorbol Acetate 136-139 interleukin 5 Mus musculus 17-21 16373364-5 2006 Strong induction of IL-5 mRNA was also induced by PMA/cAMP. Tetradecanoylphorbol Acetate 50-53 interleukin 5 Mus musculus 20-24 10410976-7 1999 Polyclonal activation of lung T cells from OA/OA mice with 12-myristate 13-acetate (PMA), ionomycin, anti-CD3 mAb, and anti-CD28 mAb resulted in higher percentages of IL-2+ (43%) and IL-5+ (7%) CD4 cells when compared to CD4+ T cells from non-OA sensitized, challenged mice. Tetradecanoylphorbol Acetate 84-87 interleukin 5 Mus musculus 183-187 9768762-2 1998 In contrast, IL-4 and IL-5 production by mast cells stimulated in vitro with PMA, ionomycin, or IgE cross-linking are unaffected. Tetradecanoylphorbol Acetate 77-80 interleukin 5 Mus musculus 22-26 9406065-7 1997 Upon stimulation of EL-4.IL-2 with phorbol-12-myristate-13-acetate, there were variable increases in interleukin-2 secretion (up to 2.4-fold for 10(6) Bifidobacterium Bf-1/ml) and interleukin-5 secretion (up to 4.6-fold for 10(8) B. adolescentis M101-4). Tetradecanoylphorbol Acetate 35-66 interleukin 5 Mus musculus 180-193 8461254-6 1993 The presence of the protein synthesis inhibitor cycloheximide completely prevented PMA-induced synthesis of IL-5 mRNA by both NIMP-TH1 and EL-4 cells, indicating that induction of IL-5 mRNA via PMA stimulation requires de novo synthesis of a presumptive trans-acting factor(s). Tetradecanoylphorbol Acetate 83-86 interleukin 5 Mus musculus 108-112 8658534-13 1996 Taken together, VT enhanced and/or delayed peak IL-2, IL-4, and IL-5 gene expression and secretion in CD4+ T cells stimulated with PMA and ionomycin. Tetradecanoylphorbol Acetate 131-134 interleukin 5 Mus musculus 64-68 8245456-4 1993 These cells produce a low level of IL-5 when stimulated with PMA alone; however, N6, O2-dibutyryl cAMP (Bt2cAMP), in combination with PMA, augmented by more than tenfold the IL-5 production at the mRNA and the protein levels. Tetradecanoylphorbol Acetate 134-137 interleukin 5 Mus musculus 35-39 8245456-4 1993 These cells produce a low level of IL-5 when stimulated with PMA alone; however, N6, O2-dibutyryl cAMP (Bt2cAMP), in combination with PMA, augmented by more than tenfold the IL-5 production at the mRNA and the protein levels. Tetradecanoylphorbol Acetate 134-137 interleukin 5 Mus musculus 174-178 9274810-7 1997 In contrast, IL-5 levels were increased significantly in 7-day PP cell cultures obtained 2 h after VT exposure both with and without PMA + ION exposure but not in other cultures. Tetradecanoylphorbol Acetate 133-138 interleukin 5 Mus musculus 13-17 8704176-3 1996 Activation of the IL-5 promoter required costimulation of T cells with phorbol ester (phorbol 12-myristate 13-acetate [PMA]) and cyclic adenosine 3",5"-monophosphate (cAMP), but was blocked by the immunosuppressive drug, cyclosporin A (CsA). Tetradecanoylphorbol Acetate 86-117 interleukin 5 Mus musculus 18-22 8704176-3 1996 Activation of the IL-5 promoter required costimulation of T cells with phorbol ester (phorbol 12-myristate 13-acetate [PMA]) and cyclic adenosine 3",5"-monophosphate (cAMP), but was blocked by the immunosuppressive drug, cyclosporin A (CsA). Tetradecanoylphorbol Acetate 119-122 interleukin 5 Mus musculus 18-22 8661368-12 1996 Taken together, VT enhanced andsolidusor delayed peak IL-2, IL-4, and IL-5 gene expression and secretion in CD4(+) T cells stimulated with PMA and ionomycin. Tetradecanoylphorbol Acetate 139-142 interleukin 5 Mus musculus 70-74 7615560-2 1995 We have previously reported that the promoter region of the mouse interleukin-5 (IL-5) gene, extending from a nucleotide position about -1,200 to +33 relative to the transcription initiation site, can mediate transcriptional stimulation by phorbol 12-myristate 13-acetate and dibutyryl cAMP (Bt2cAMP) in mouse thymoma EL-4 cells. Tetradecanoylphorbol Acetate 240-271 interleukin 5 Mus musculus 66-79 7615560-2 1995 We have previously reported that the promoter region of the mouse interleukin-5 (IL-5) gene, extending from a nucleotide position about -1,200 to +33 relative to the transcription initiation site, can mediate transcriptional stimulation by phorbol 12-myristate 13-acetate and dibutyryl cAMP (Bt2cAMP) in mouse thymoma EL-4 cells. Tetradecanoylphorbol Acetate 240-271 interleukin 5 Mus musculus 81-85 8204886-3 1994 The induction of IL-5 mRNA by phorbol 12-myristate 13-acetate (PMA) stimulation was found to be cyclosporin A-resistant, in contrast to the induction of IL-2 and GM-CSF mRNAs. Tetradecanoylphorbol Acetate 30-61 interleukin 5 Mus musculus 17-21 8204886-3 1994 The induction of IL-5 mRNA by phorbol 12-myristate 13-acetate (PMA) stimulation was found to be cyclosporin A-resistant, in contrast to the induction of IL-2 and GM-CSF mRNAs. Tetradecanoylphorbol Acetate 63-66 interleukin 5 Mus musculus 17-21 8461254-6 1993 The presence of the protein synthesis inhibitor cycloheximide completely prevented PMA-induced synthesis of IL-5 mRNA by both NIMP-TH1 and EL-4 cells, indicating that induction of IL-5 mRNA via PMA stimulation requires de novo synthesis of a presumptive trans-acting factor(s). Tetradecanoylphorbol Acetate 83-86 interleukin 5 Mus musculus 180-184 1680700-6 1991 When concanavalin A (Con A)-activated spleen cells were restimulated with Con A and phorbol 12-myristate 13-acetate (PMA), higher levels of IL2, IL4 and IL5 mRNA were induced, as detected both by increased frequencies of positive cells, and by more mRNA per cell. Tetradecanoylphorbol Acetate 117-120 interleukin 5 Mus musculus 153-156 8461254-3 1993 Progesterone and testosterone were as effective as PMA in inducing IL-5 mRNA levels in the T cell hybrid NIMP-TH1 and induced IL-5, -3 and -2 mRNA accumulation in the T cell lymphoma EL-4. Tetradecanoylphorbol Acetate 51-54 interleukin 5 Mus musculus 67-71 8461254-3 1993 Progesterone and testosterone were as effective as PMA in inducing IL-5 mRNA levels in the T cell hybrid NIMP-TH1 and induced IL-5, -3 and -2 mRNA accumulation in the T cell lymphoma EL-4. Tetradecanoylphorbol Acetate 51-54 interleukin 5 Mus musculus 126-141 1680700-6 1991 When concanavalin A (Con A)-activated spleen cells were restimulated with Con A and phorbol 12-myristate 13-acetate (PMA), higher levels of IL2, IL4 and IL5 mRNA were induced, as detected both by increased frequencies of positive cells, and by more mRNA per cell. Tetradecanoylphorbol Acetate 84-115 interleukin 5 Mus musculus 153-156 2090920-7 1990 Addition of phorbol 12-myristate 13-acetate (PMA) or IL-4 to the culture of BCL1-B20 cells inhibited both the IL-5-mediated augmentation of IgM secretion and the elevated expression of c-myc mRNA. Tetradecanoylphorbol Acetate 12-43 interleukin 5 Mus musculus 110-114 1831130-1 1991 Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens. Tetradecanoylphorbol Acetate 89-120 interleukin 5 Mus musculus 219-222 1831130-1 1991 Activation of murine spleen cells in vitro with soluble anti-CD3 monoclonal antibody and phorbol 12-myristate 13-acetate (PMA) induced an initial production of interleukin 2 (IL2), interferon-gamma (IFN-gamma), IL4 and IL5, followed by a refractory state during which the T cells did not produce lymphokines when stimulated with some common mitogens. Tetradecanoylphorbol Acetate 122-125 interleukin 5 Mus musculus 219-222 2090920-7 1990 Addition of phorbol 12-myristate 13-acetate (PMA) or IL-4 to the culture of BCL1-B20 cells inhibited both the IL-5-mediated augmentation of IgM secretion and the elevated expression of c-myc mRNA. Tetradecanoylphorbol Acetate 45-48 interleukin 5 Mus musculus 110-114 2893824-11 1988 The expression of TRF/IL-5 mRNA in B151K12 was augmented by the stimulation with PMA plus calcium ionophore. Tetradecanoylphorbol Acetate 81-84 interleukin 5 Mus musculus 22-26 2613691-7 1989 Addition of phorbol 12-myristate 13-acetate (PMA) to the culture inhibited IL5-mediated differentiative responses. Tetradecanoylphorbol Acetate 12-43 interleukin 5 Mus musculus 75-78 2613691-7 1989 Addition of phorbol 12-myristate 13-acetate (PMA) to the culture inhibited IL5-mediated differentiative responses. Tetradecanoylphorbol Acetate 45-48 interleukin 5 Mus musculus 75-78 2893824-11 1988 The expression of TRF/IL-5 mRNA in B151K12 was augmented by the stimulation with PMA plus calcium ionophore. Tetradecanoylphorbol Acetate 81-84 interleukin 5 Mus musculus 18-21 2827895-8 1988 BCGF-II in the presence of low doses (0.1 microgram/ml) of phorbol myristate acetate (PMA) also induced Tac Ag mRNA (3.5 and 1.5 kb) in these B-cell lines. Tetradecanoylphorbol Acetate 59-84 interleukin 5 Mus musculus 0-7 31932824-3 2020 This study aimed to investigate the underlying mechanisms of ROS and IL-5 reduction with citrus flavonoid treatment in PMA/ionomycin-induced EL-4 cells. Tetradecanoylphorbol Acetate 119-122 interleukin 5 Mus musculus 69-73