PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1493921-2 1992 IL-5 expression was stimulated by phytohaemagglutinin (PHA), IL-2, phorbol myristate acetate (PMA) or Ionomycin. Tetradecanoylphorbol Acetate 67-92 interleukin 5 Homo sapiens 0-4 8419187-4 1993 After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells. Tetradecanoylphorbol Acetate 23-54 interleukin 5 Homo sapiens 156-160 8419187-4 1993 After stimulation with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187, they produced higher levels of IL-4 (306 vs. 55 +/- 4 pg/ml) and IL-5 (2900 vs. 213 +/- 72 pg/ml) and lower levels of IL-2 (17 vs. 63 +/- 17 IU/ml) and interferon-gamma (IFN-gamma) (16 vs. 299 +/- 70 IU/ml) than controls CD4+ CD45R0+ cells. Tetradecanoylphorbol Acetate 56-59 interleukin 5 Homo sapiens 156-160 1493921-2 1992 IL-5 expression was stimulated by phytohaemagglutinin (PHA), IL-2, phorbol myristate acetate (PMA) or Ionomycin. Tetradecanoylphorbol Acetate 94-97 interleukin 5 Homo sapiens 0-4 1493921-5 1992 Dexamethasone at 10(-6) M also profoundly inhibited the IL-5 response to PMA and to IL-2, but the IL-5 response to Ionomycin was not significantly affected. Tetradecanoylphorbol Acetate 73-76 interleukin 5 Homo sapiens 56-60 1370514-8 1992 Stimulation with Con A also induced very low or no measurable levels of IL-2 and IFN-gamma, whereas activation with TPA and the calcium ionophore A23187 resulted in the production of high levels of IL-4, IL-5, IL-2, and IFN-gamma. Tetradecanoylphorbol Acetate 116-119 interleukin 5 Homo sapiens 204-208 30566262-8 2019 Up-regulation of cytokines (TSLP, IL-4, IL-5, IL-13, RANTES) in human mast cells treated with phorbol 12-myristate 13-acetate and calcium ionophore was also suppressed by boehmite. Tetradecanoylphorbol Acetate 94-125 interleukin 5 Homo sapiens 40-44 1537597-0 1992 Expression of interleukin-5 and granulocyte-macrophage colony-stimulating factor in human peripheral blood mononuclear cells after activation with phorbol myristate acetate. Tetradecanoylphorbol Acetate 147-172 interleukin 5 Homo sapiens 14-27 1371491-8 1992 When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha. Tetradecanoylphorbol Acetate 49-80 interleukin 5 Homo sapiens 206-210 1371491-8 1992 When the cells were stimulated by phorbol ester (phorbol 12-myristate 13-acetate, PMA) plus calcium ionophore (ionomycin), FK506 and CsA inhibited, in a dose-dependent manner, the production of IL-2, IL-4, IL-5, IFN-gamma and TNF-alpha. Tetradecanoylphorbol Acetate 82-85 interleukin 5 Homo sapiens 206-210 2242429-8 1990 In contrast, the fourth patient, a nonresponder to SAC or TPA/Ca2+, demonstrated increased DNA synthesis at day 3 when cocultured with IL-4 and IL-5. Tetradecanoylphorbol Acetate 58-61 interleukin 5 Homo sapiens 144-148 24801891-5 2014 Phorbol myristate acetate-stimulated whole blood interleukin (IL)-4, IL-5, IL-10, IL-12, IL-13, IL-17A, IL-17F, IL-22, and interferon-gamma secretory responses were analyzed for associations comparing participants with allergic vs nonallergic asthma phenotypes with those without asthma. Tetradecanoylphorbol Acetate 0-25 interleukin 5 Homo sapiens 69-73 17438848-6 2007 The percentage of cells of active AP-1, IL-5 protein in supernatants of allergic rhinitis T lymphocytes stimulated with PMA and curcumin were significantly lower than those of allergic rhinitis T lymphocytes stimulated with PMA (P < 0.01); but significantly higher than those of allergic rhinitis T lymphocytes stimulated without PMA and those of deflection of nasal septum T lymphocytes stimulated. Tetradecanoylphorbol Acetate 120-123 interleukin 5 Homo sapiens 40-44 23711861-8 2013 Furthermore, the ex vivo production of interleukin (IL)-5 by PBMCs in response to both mite allergen and ionomycin/PMA decreased significantly. Tetradecanoylphorbol Acetate 115-118 interleukin 5 Homo sapiens 39-57 18325701-7 2008 RESULTS: HcFs inhibited the expression of IL-4 and IL-5 in response to phorbol 12-myristate 13-acetate (PMA) and calcium ionophore (CaI) in Jurkat T cells and the human mast cell line, HMC-1. Tetradecanoylphorbol Acetate 71-102 interleukin 5 Homo sapiens 51-55 18325701-7 2008 RESULTS: HcFs inhibited the expression of IL-4 and IL-5 in response to phorbol 12-myristate 13-acetate (PMA) and calcium ionophore (CaI) in Jurkat T cells and the human mast cell line, HMC-1. Tetradecanoylphorbol Acetate 104-107 interleukin 5 Homo sapiens 51-55 9432015-3 1997 Using RT-PCR, IL-5 mRNA was expressed by BMEC after stimulation (12 h) with lipopolysaccharide (LPS), IL-1, IL-2 and phorbol myristate acetate (PMA), but not by resting BMEC, after stimulation with TNF-alpha or interferon (IFN)-gamma. Tetradecanoylphorbol Acetate 117-142 interleukin 5 Homo sapiens 14-18 15556684-3 2004 Using enzyme-linked immunosorbent assay, we measured unstimulated and concanavalin A/phorbol myristate acetate-stimulated production of interleukin-4 (IL-4), IL-5, IL-10, IL-13 and interferon- gamma (IFN-gamma) by decidual explants from 59 healthy women delivered by unlabored cesarean section and from corresponding CBMCs in 39 of the 59. Tetradecanoylphorbol Acetate 85-110 interleukin 5 Homo sapiens 158-162 11359422-0 2001 IL-5 priming of the PMA-induced oxidative metabolism of human eosinophils from allergic and normal subjects during a pollen season. Tetradecanoylphorbol Acetate 20-23 interleukin 5 Homo sapiens 0-4 11359422-8 2001 IL-5 reduced the total PMA CL response both in control and patients" cells (P = 0.012 and 0.0054 resp.), whereas it primed it in terms of the t(1/2)rise of the curves, in both groups (P = 0.012 and 0.0015 resp.). Tetradecanoylphorbol Acetate 23-26 interleukin 5 Homo sapiens 0-4 11359422-12 2001 Interleukin-5 primes equally the PMA-induced oxidative metabolism of human eosinophils from healthy or allergic subjects. Tetradecanoylphorbol Acetate 33-36 interleukin 5 Homo sapiens 0-13 11359422-13 2001 The mechanism of IL-5 priming after PMA stimulation of oxygen radical production is MEK independent. Tetradecanoylphorbol Acetate 36-39 interleukin 5 Homo sapiens 17-21 10886243-7 2000 In accordance with this, CD80 and phorbol myristate acetate (PMA) (without anti-CD3 or calcium ionophore) were sufficient to induce production of IL-5 and IL-13, but not of IL-4. Tetradecanoylphorbol Acetate 34-59 interleukin 5 Homo sapiens 146-150 10886243-7 2000 In accordance with this, CD80 and phorbol myristate acetate (PMA) (without anti-CD3 or calcium ionophore) were sufficient to induce production of IL-5 and IL-13, but not of IL-4. Tetradecanoylphorbol Acetate 61-64 interleukin 5 Homo sapiens 146-150 16116958-6 2005 58+/-1 626.57) and the expression of IL-5 mRNA (0.8300+/-0.0294) in T lymphocytes stimulated with PMA were significantly higher than these in blank control (20888.47 +/- 1103.56 and 0.3050 +/- 0.0208, respectively, P< 0.01), while the indexes (23219.83 +/- 1024.86 and 0.3425 +/- 0.0171 respectively) of T lymphocytes stimulated with PMA and AP-1 decoy ODNs were significantly inhibited, as compared with group B (P< 0.01). Tetradecanoylphorbol Acetate 98-101 interleukin 5 Homo sapiens 37-41 12871219-2 2003 Both peripheral blood mononuclear cells (PBMC) and primary human T cells display similar patterns of IL-5 expression when stimulated with both phorbol-12-myristate 13-acetate and phytohaemagglutinin. Tetradecanoylphorbol Acetate 143-174 interleukin 5 Homo sapiens 101-105 11961080-5 2002 The IC(50) for IL-5 and IL-13 in TPA/ionomycin-stimulated peripheral blood mononuclear cells (PBMC) is 0.7 +/- 0.1 and 0.5 +/- 0.1 microM, respectively, whereas the IC(50) for IFN-gamma is 2.0 +/- 0.4 microM. Tetradecanoylphorbol Acetate 33-36 interleukin 5 Homo sapiens 15-19 11517513-4 2001 Interleukin (IL)-5 production by PBMCs stimulated with the combination of phorbol myristate acetate and ionomycin were reduced significantly 6 or 12 weeks after the treatment with supratast tosilate. Tetradecanoylphorbol Acetate 74-99 interleukin 5 Homo sapiens 0-18 11238569-4 2001 Moreover, the NK cells from MS in remission produced much larger amounts of IL-5 than did those from controls after stimulation with phorbol myristate acetate (PMA) and ionomycin. Tetradecanoylphorbol Acetate 133-158 interleukin 5 Homo sapiens 76-80 11238569-4 2001 Moreover, the NK cells from MS in remission produced much larger amounts of IL-5 than did those from controls after stimulation with phorbol myristate acetate (PMA) and ionomycin. Tetradecanoylphorbol Acetate 160-163 interleukin 5 Homo sapiens 76-80 12539551-4 2001 The expression of IL-4 and IL-5 mRNA and protein of asthmatic T lymphocytes stimulated with PMA was significantly higher than that of asthmatic T lymphocytes stimulated without PMA respectively (P < 0.01) and that of normal T lymphocytes stimulated with PMA respectively (P < 0.01). Tetradecanoylphorbol Acetate 92-95 interleukin 5 Homo sapiens 27-31 12539551-4 2001 The expression of IL-4 and IL-5 mRNA and protein of asthmatic T lymphocytes stimulated with PMA was significantly higher than that of asthmatic T lymphocytes stimulated without PMA respectively (P < 0.01) and that of normal T lymphocytes stimulated with PMA respectively (P < 0.01). Tetradecanoylphorbol Acetate 177-180 interleukin 5 Homo sapiens 27-31 12539551-4 2001 The expression of IL-4 and IL-5 mRNA and protein of asthmatic T lymphocytes stimulated with PMA was significantly higher than that of asthmatic T lymphocytes stimulated without PMA respectively (P < 0.01) and that of normal T lymphocytes stimulated with PMA respectively (P < 0.01). Tetradecanoylphorbol Acetate 177-180 interleukin 5 Homo sapiens 27-31 12539551-5 2001 The expression of IL-4 and IL-5 mRNA and protein of asthmatic T lymphocytes stimulated with PMA and Ro31-8220 was significantly lower than that of asthmatic T lymphocytes stimulated only with PMA respectively (P < 0.01). Tetradecanoylphorbol Acetate 92-95 interleukin 5 Homo sapiens 27-31 12168042-1 1998 hIL-5 cDNA was amplified through reverse transcription-polymerase chain reaction from peripheral blood lymphocytes induced with PMA and calcium ionophore A23187. Tetradecanoylphorbol Acetate 128-131 interleukin 5 Homo sapiens 0-5 9503684-5 1997 Furthermore, the frequency of T cells which produced IL-4, IL-5 and IFN-gamma stimulated with phorbol myristate acetate and ionomycin increased and reduced in parallel with MFI of EG2-positive cells. Tetradecanoylphorbol Acetate 94-119 interleukin 5 Homo sapiens 59-63 9432015-3 1997 Using RT-PCR, IL-5 mRNA was expressed by BMEC after stimulation (12 h) with lipopolysaccharide (LPS), IL-1, IL-2 and phorbol myristate acetate (PMA), but not by resting BMEC, after stimulation with TNF-alpha or interferon (IFN)-gamma. Tetradecanoylphorbol Acetate 144-147 interleukin 5 Homo sapiens 14-18 9271313-7 1997 CsA and FK506 strongly inhibited cellular IL-5 mRNA expression in response to phytohemagglutinin (PHA), or to phorbol myristate acetate (PMA), and/or calcium ionophore. Tetradecanoylphorbol Acetate 110-135 interleukin 5 Homo sapiens 42-46 9271313-7 1997 CsA and FK506 strongly inhibited cellular IL-5 mRNA expression in response to phytohemagglutinin (PHA), or to phorbol myristate acetate (PMA), and/or calcium ionophore. Tetradecanoylphorbol Acetate 137-140 interleukin 5 Homo sapiens 42-46 7791790-6 1995 Cotransfection experiments revealed that both hGATA-4 and phorbol-12-myristate-13-acetate (PMA)-A23187 stimulation are necessary for IL-5 promoter activation. Tetradecanoylphorbol Acetate 58-89 interleukin 5 Homo sapiens 133-137 9107303-10 1997 After activation with phorbol myristate acetate and ionomycin, the half-life of IL-5 mRNA was 2.6 h in HSB-2 cells and 4.0 h in T cells prepared from human blood. Tetradecanoylphorbol Acetate 22-47 interleukin 5 Homo sapiens 80-84 8999940-0 1997 Activation of 12-O-tetradecanoylphorbol-13-acetate response element- and dyad symmetry element-dependent transcription by interleukin-5 is mediated by Jun N-terminal kinase/stress-activated protein kinase kinases. Tetradecanoylphorbol Acetate 14-50 interleukin 5 Homo sapiens 122-135 8999940-5 1997 We show that IL-5 activates TPA response element (TRE)-dependent transcription in transfection experiments. Tetradecanoylphorbol Acetate 28-31 interleukin 5 Homo sapiens 13-17 8625537-9 1996 Similar but transient inhibition of most T-cell products (IL-2, IL-3, IL-4, IL-5, IL-10, TNF-beta and GM-CSF) was noted in the PMA/ionomycin-containing cultures. Tetradecanoylphorbol Acetate 127-130 interleukin 5 Homo sapiens 76-80 9095665-4 1997 IL-5 production by activated T-lymphocytes which are known to play a major role in chronic GVHD was upregulated when stimulated by PMA + ionomycin. Tetradecanoylphorbol Acetate 131-134 interleukin 5 Homo sapiens 0-4 8973627-4 1996 The CD4+CD7- subpopulation was found to secrete significantly higher levels of IL-5 compared with the CD4+CD7- subset upon stimulation with ionomycin/phorbol myristate acetate (PMA) plus anti-CD28 MoAbs. Tetradecanoylphorbol Acetate 150-175 interleukin 5 Homo sapiens 79-83 8973627-4 1996 The CD4+CD7- subpopulation was found to secrete significantly higher levels of IL-5 compared with the CD4+CD7- subset upon stimulation with ionomycin/phorbol myristate acetate (PMA) plus anti-CD28 MoAbs. Tetradecanoylphorbol Acetate 177-180 interleukin 5 Homo sapiens 79-83 7594459-3 1995 These activated T cells produced IL-2, IL-4, IL-5, and IFN-gamma upon stimulation with PMA and ionomycin. Tetradecanoylphorbol Acetate 87-90 interleukin 5 Homo sapiens 45-49 7791790-6 1995 Cotransfection experiments revealed that both hGATA-4 and phorbol-12-myristate-13-acetate (PMA)-A23187 stimulation are necessary for IL-5 promoter activation. Tetradecanoylphorbol Acetate 91-94 interleukin 5 Homo sapiens 133-137 7923875-2 1994 Upon stimulation with allergen or anti-CD3+ phorbol myristate acetate (PMA) IL-4 was released with or without IL-5, while no (or extremely low concentrations of) IL-2 and interferon-gamma (IFN-gamma) were detectable. Tetradecanoylphorbol Acetate 44-69 interleukin 5 Homo sapiens 110-114 7774647-3 1995 Phorbol 12-myristate 13-acetate, A23187 and N6, 2"-O-dibutyryl-adenosine 3":5"-cyclic monophosphate co-stimulation of EL4 cells transfected with the human IL-5/luciferase reporter gene construct resulted in maximal induction of the luciferase gene. Tetradecanoylphorbol Acetate 0-31 interleukin 5 Homo sapiens 155-159 7542077-2 1995 Stimuli delivered by the combination of phorbol ester (PMA) and CA2+ ionophore (ionomycin) induced marked IL-5 production by PBMCs obtained from atopic as well as nonatopic asthmatics. Tetradecanoylphorbol Acetate 55-58 interleukin 5 Homo sapiens 106-110 7923875-2 1994 Upon stimulation with allergen or anti-CD3+ phorbol myristate acetate (PMA) IL-4 was released with or without IL-5, while no (or extremely low concentrations of) IL-2 and interferon-gamma (IFN-gamma) were detectable. Tetradecanoylphorbol Acetate 71-74 interleukin 5 Homo sapiens 110-114 7835952-5 1994 In four of five patients studied, phorbol myristate acetate (PMA) stimulation of PBMC induced them to produce more IL-5 mRNA than four healthy subjects. Tetradecanoylphorbol Acetate 34-59 interleukin 5 Homo sapiens 115-119 7835952-5 1994 In four of five patients studied, phorbol myristate acetate (PMA) stimulation of PBMC induced them to produce more IL-5 mRNA than four healthy subjects. Tetradecanoylphorbol Acetate 61-64 interleukin 5 Homo sapiens 115-119 7909823-6 1994 Primed cells are enriched in CD45R0hi and CD31- cells, and upon stimulation with PMA+ ionomycin they release significant amounts of IL-2, IFN-gamma, IL-4, IL-5, and IL-10. Tetradecanoylphorbol Acetate 81-84 interleukin 5 Homo sapiens 155-159 7914436-4 1994 The protein kinase C (PKC) activator phorbol myristate acetate (PMA) triggered both IL-3 and IL-5 mRNA expression, whereby IL-5 and IL-3 mRNA expression was observed after 9 and 3 h treatment, respectively. Tetradecanoylphorbol Acetate 37-62 interleukin 5 Homo sapiens 93-97 7914436-4 1994 The protein kinase C (PKC) activator phorbol myristate acetate (PMA) triggered both IL-3 and IL-5 mRNA expression, whereby IL-5 and IL-3 mRNA expression was observed after 9 and 3 h treatment, respectively. Tetradecanoylphorbol Acetate 37-62 interleukin 5 Homo sapiens 123-127 7914436-4 1994 The protein kinase C (PKC) activator phorbol myristate acetate (PMA) triggered both IL-3 and IL-5 mRNA expression, whereby IL-5 and IL-3 mRNA expression was observed after 9 and 3 h treatment, respectively. Tetradecanoylphorbol Acetate 64-67 interleukin 5 Homo sapiens 93-97 7914436-4 1994 The protein kinase C (PKC) activator phorbol myristate acetate (PMA) triggered both IL-3 and IL-5 mRNA expression, whereby IL-5 and IL-3 mRNA expression was observed after 9 and 3 h treatment, respectively. Tetradecanoylphorbol Acetate 64-67 interleukin 5 Homo sapiens 123-127 8018594-4 1994 In contrast, in cells stimulated with phorbol myristate acetate (PMA)/A23187, PGE2 enhanced the production of IL-4 and IL-5, and only partially inhibited the production of other cytokines. Tetradecanoylphorbol Acetate 38-63 interleukin 5 Homo sapiens 119-123 8018594-4 1994 In contrast, in cells stimulated with phorbol myristate acetate (PMA)/A23187, PGE2 enhanced the production of IL-4 and IL-5, and only partially inhibited the production of other cytokines. Tetradecanoylphorbol Acetate 65-68 interleukin 5 Homo sapiens 119-123 7905497-7 1994 In response to primary stimulation with PMA and ionomycin, cells primed with IL-4 + IL-2 produce IL-4, IL-5, and IL-10 and the same levels of IL-2 and IFN-gamma as IL-4-primed cells. Tetradecanoylphorbol Acetate 40-43 interleukin 5 Homo sapiens 103-107