PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26372376-6 2015 Firstly, AgNPs inhibit phorbol 12-myristate 13-acetate (PMA)-induced monocyte differentiation by down-regulating both expression of surface marker CD11b and response to lipopolysaccharide (LPS) stimulation. Tetradecanoylphorbol Acetate 56-59 integrin subunit alpha M Homo sapiens 147-152 27257341-4 2016 Of the four polyphenols tested, CAPE significantly suppressed the 12-O-tetradecanoylphorbol 13-acetate (TPA)-elicited expression of cluster for differentiation (CD) 11b, 14, and 36, and this was accompanied by the inhibition of THP-1 cell adhesion to HUVEC. Tetradecanoylphorbol Acetate 66-102 integrin subunit alpha M Homo sapiens 132-168 27257341-4 2016 Of the four polyphenols tested, CAPE significantly suppressed the 12-O-tetradecanoylphorbol 13-acetate (TPA)-elicited expression of cluster for differentiation (CD) 11b, 14, and 36, and this was accompanied by the inhibition of THP-1 cell adhesion to HUVEC. Tetradecanoylphorbol Acetate 104-107 integrin subunit alpha M Homo sapiens 132-168 23434434-9 2013 Physostigmine, in the concentration range tested, suppressed the expression of CD11b following stimulation with PMA not significantly (human PMN: control: 63.1+-10.7 vs. 97 muM physostigmine: 49.9+-12.8 MESF, p=n.s.). Tetradecanoylphorbol Acetate 112-115 integrin subunit alpha M Homo sapiens 79-84 24962779-6 2014 In a DMBA/TPA-induced mouse skin tumor model, inhibition of Rac1 activity and depletion of CD11b+Gr1+ cells resulted in significant tumor formation. Tetradecanoylphorbol Acetate 10-13 integrin subunit alpha M Homo sapiens 91-96 24962779-7 2014 TPA induced recruitment of CD11b+Gr1+ cells into dermis; however, Rac1 inhibitor abolished this recruitment. Tetradecanoylphorbol Acetate 0-3 integrin subunit alpha M Homo sapiens 27-32 26414495-7 2015 Production of reactive oxygen species (ROS) induced by PMA (126.7 +- 2.1%) was markedly attenuated by curcumin, DMC, and BDMC to 99.5 +- 7.8%, 87.8 +- 8.2%, and 89.8 +- 7.6%, respectively, resulting in the down-regulation of CD11b and MMP-9 expression. Tetradecanoylphorbol Acetate 55-58 integrin subunit alpha M Homo sapiens 225-230 25130808-10 2014 The cells treated with both TPA and As2O3 expressed far more CD11b antigens compared with cells exposed to As2O3 alone. Tetradecanoylphorbol Acetate 28-31 integrin subunit alpha M Homo sapiens 61-66 24985180-9 2014 Cells treated with both TPA and As2O3 expressed more CD11b antigens compared with the cells exposed to As2O3 alone. Tetradecanoylphorbol Acetate 24-27 integrin subunit alpha M Homo sapiens 53-58 23490067-7 2013 AA clearly increased TPA-induced HL-60 cell differentiation, as evidenced by a marked increase in CD11b expression, which was inhibited by NAC and PD98059 addition. Tetradecanoylphorbol Acetate 21-24 integrin subunit alpha M Homo sapiens 98-103 23216989-7 2012 In contrast, PMA-induced THP-1 differentiation toward monocytic cells expressed CD11b+, and CD14+, but not CD123, and revealed exclusively IL-12 expression while stimulated by dengue-2. Tetradecanoylphorbol Acetate 13-16 integrin subunit alpha M Homo sapiens 80-85 22607136-1 2012 Previous work has demonstrated that phorbol ester (TPA)-induced adherence of human U937 myeloid leukemia cells can be blocked upon down-modulation of the beta2-integrin CD11b after stable transfection of U937 cells with a pMTH1 vector-containing the CD11b gene in antisense orientation (asCD11b-U937) [Otte et al., (2011)]. Tetradecanoylphorbol Acetate 51-54 integrin subunit alpha M Homo sapiens 169-174 22607136-1 2012 Previous work has demonstrated that phorbol ester (TPA)-induced adherence of human U937 myeloid leukemia cells can be blocked upon down-modulation of the beta2-integrin CD11b after stable transfection of U937 cells with a pMTH1 vector-containing the CD11b gene in antisense orientation (asCD11b-U937) [Otte et al., (2011)]. Tetradecanoylphorbol Acetate 51-54 integrin subunit alpha M Homo sapiens 250-255 21804018-4 2011 Moreover, PMA-induced IL-1beta production was significantly reduced in the presence of TLR2, TLR4, and CD11b Abs. Tetradecanoylphorbol Acetate 10-13 integrin subunit alpha M Homo sapiens 103-108 16374778-6 2006 PMA, which mimics diacylglycerol (DAG) as an activator of cPKC, novel-PKC (nPKC), and non-PKC DAG-driven molecule(s), produced a dose-dependent dual effect on phagocytosis by CR3/MAC-1 and SRAI/II, i.e., augmentation at low concentrations and inhibition at high concentrations. Tetradecanoylphorbol Acetate 0-3 integrin subunit alpha M Homo sapiens 179-184 21336564-4 2011 Rapamycin potentiated differentiation of ATRA-treated NB4 cells, but the combination of rapamycin and LY 294002 inhibited the expression of CD11b in both ATRA- and phorbol myristate acetate (PMA)-stimulated cells more than PI3K inhibitor alone. Tetradecanoylphorbol Acetate 164-189 integrin subunit alpha M Homo sapiens 140-145 21336564-4 2011 Rapamycin potentiated differentiation of ATRA-treated NB4 cells, but the combination of rapamycin and LY 294002 inhibited the expression of CD11b in both ATRA- and phorbol myristate acetate (PMA)-stimulated cells more than PI3K inhibitor alone. Tetradecanoylphorbol Acetate 191-194 integrin subunit alpha M Homo sapiens 140-145 18617650-5 2008 Cyclodextrin, but not cyclodextrin/cholesterol complex, also inhibited PMA-induced CD11b activation implicating cholesterol efflux as the main mechanism. Tetradecanoylphorbol Acetate 71-74 integrin subunit alpha M Homo sapiens 83-88 17826795-12 2007 In experiment 2, GLN increased expression of CD11b and reactive oxygen intermediate with phorbol myristate acetate, compared with controls. Tetradecanoylphorbol Acetate 89-114 integrin subunit alpha M Homo sapiens 45-50 17398109-6 2007 RESULTS: Patients with low levels of preoperative basal neutrophil CD11b expression had the greatest increase in CD11b following phorbol-12-myristate-13-acetate stimulation. Tetradecanoylphorbol Acetate 129-160 integrin subunit alpha M Homo sapiens 67-72 17398109-6 2007 RESULTS: Patients with low levels of preoperative basal neutrophil CD11b expression had the greatest increase in CD11b following phorbol-12-myristate-13-acetate stimulation. Tetradecanoylphorbol Acetate 129-160 integrin subunit alpha M Homo sapiens 113-118 16374778-7 2006 Inhibition of phagocytosis by CR3/MAC-1 was enhanced by combining inhibiting concentrations of PMA with PKC inhibitors Go-6976 or Ro-318220, suggesting inhibition by PMA/DAG-driven non-PKC molecule(s). Tetradecanoylphorbol Acetate 95-98 integrin subunit alpha M Homo sapiens 34-39 16228063-0 2005 Mechanism of CD11b down-regulation from phorbol myristate acetate stimulated polymorphonuclear neutrophils. Tetradecanoylphorbol Acetate 40-65 integrin subunit alpha M Homo sapiens 13-18 16111532-4 2005 TPA induced the following antigens in decreasing order of the change: CD11c, CD9, CD11b, CD54, CD38, CD45RO and CD66c, with repression of CD4, CD117, CD95, CD71 and CD64. Tetradecanoylphorbol Acetate 0-3 integrin subunit alpha M Homo sapiens 82-87 16228063-1 2005 OBJECTIVE: To investigate the mechanism of CD11b down-regulation in phorbol myristate acetate (PMA) stimulated polymorphonuclear leukocytes (PMN). Tetradecanoylphorbol Acetate 68-93 integrin subunit alpha M Homo sapiens 43-48 16228063-1 2005 OBJECTIVE: To investigate the mechanism of CD11b down-regulation in phorbol myristate acetate (PMA) stimulated polymorphonuclear leukocytes (PMN). Tetradecanoylphorbol Acetate 95-98 integrin subunit alpha M Homo sapiens 43-48 12960243-4 2003 Immunoprecipitation experiments using plasma membranes of phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils revealed coimmunoprecipitation of PR3 with CD11b/CD18, indicating their location in the same complex. Tetradecanoylphorbol Acetate 58-89 integrin subunit alpha M Homo sapiens 162-167 12960243-4 2003 Immunoprecipitation experiments using plasma membranes of phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils revealed coimmunoprecipitation of PR3 with CD11b/CD18, indicating their location in the same complex. Tetradecanoylphorbol Acetate 91-94 integrin subunit alpha M Homo sapiens 162-167 15620108-6 2004 The fluorescence of CD18 and CD11b reappeared on the cell membrane 1 h after re-treatment with PMA, suggesting the recycling of non-degraded Mac-1. Tetradecanoylphorbol Acetate 95-98 integrin subunit alpha M Homo sapiens 29-34 15620108-6 2004 The fluorescence of CD18 and CD11b reappeared on the cell membrane 1 h after re-treatment with PMA, suggesting the recycling of non-degraded Mac-1. Tetradecanoylphorbol Acetate 95-98 integrin subunit alpha M Homo sapiens 141-146 12225365-2 2002 Phorbol 12-myristate 13-acetate (PMA) caused time- and concentration-dependent adhesion of AML cells to plated bovine serum albumin (BSA), which was blocked by anti-CD11b or anti-CD18 monoclonal antibodies (mAb) directed against beta2-integrin. Tetradecanoylphorbol Acetate 0-31 integrin subunit alpha M Homo sapiens 165-170 12689660-11 2003 CD11b(+)Gr-1(+) cells isolated from the blood or spleen of TCDD-treated mice produced up to fivefold higher levels of superoxide following PMA stimulation when compared with cells from vehicle-treated mice. Tetradecanoylphorbol Acetate 139-142 integrin subunit alpha M Homo sapiens 0-5 12225365-2 2002 Phorbol 12-myristate 13-acetate (PMA) caused time- and concentration-dependent adhesion of AML cells to plated bovine serum albumin (BSA), which was blocked by anti-CD11b or anti-CD18 monoclonal antibodies (mAb) directed against beta2-integrin. Tetradecanoylphorbol Acetate 33-36 integrin subunit alpha M Homo sapiens 165-170 11287316-3 2001 Phosphorylation of p92 was inducible when Mac-1 was activated by phorbol 12-myristate 13-acetate, the beta(2)-specific activating antibody CBR LFA-1/2, or interleukin-8 (77 amino acids). Tetradecanoylphorbol Acetate 65-96 integrin subunit alpha M Homo sapiens 42-47 11893077-4 2002 Expression of the CD11b antisense gene in stably transfected U937 cells (as-CD11b cells) resulted in an attenuated response to TPA. Tetradecanoylphorbol Acetate 127-130 integrin subunit alpha M Homo sapiens 18-23 11893077-4 2002 Expression of the CD11b antisense gene in stably transfected U937 cells (as-CD11b cells) resulted in an attenuated response to TPA. Tetradecanoylphorbol Acetate 127-130 integrin subunit alpha M Homo sapiens 76-81 11893077-5 2002 As-CD11b cells demonstrated poor adhesion to solid substrate upon TPA treatment in contrast to U937 control cells. Tetradecanoylphorbol Acetate 66-69 integrin subunit alpha M Homo sapiens 3-8 11893077-9 2002 According to the failure to undergo a monocytic differentiation program, TPA treatment of as-CD11b cells resulted in a progressively increasing amount of apoptotic cells whereas the differentiated population of U937 control cells remained alive. Tetradecanoylphorbol Acetate 73-76 integrin subunit alpha M Homo sapiens 93-98 11587160-9 2001 Stimulation with PMA caused more rapid activation in EHT neutrophils with expression of CD11b, followed rapidly by exocytosis of primary granules. Tetradecanoylphorbol Acetate 17-20 integrin subunit alpha M Homo sapiens 88-93 12061815-2 2002 Exposure of U937 cells to 1 mM SB and 1 nM PMA (24 h) markedly induced caspase activation and apoptosis, events accompanied by impaired differentiation induction (e.g., reduced plastic adherence and diminished expression of CD11b) as well as reduced clonogenic survival. Tetradecanoylphorbol Acetate 43-46 integrin subunit alpha M Homo sapiens 224-229 11514958-4 2001 Basal and phorbol myristate acetate (PMA)-stimulated oxidative burst and CD11b expression were determined using dihydrorhodamine 123 and phycoerythrin (PE)-conjugated anti-CD11b monoclonal antibodies. Tetradecanoylphorbol Acetate 37-40 integrin subunit alpha M Homo sapiens 73-78 11514958-4 2001 Basal and phorbol myristate acetate (PMA)-stimulated oxidative burst and CD11b expression were determined using dihydrorhodamine 123 and phycoerythrin (PE)-conjugated anti-CD11b monoclonal antibodies. Tetradecanoylphorbol Acetate 37-40 integrin subunit alpha M Homo sapiens 172-177 9788660-8 1998 PMNs in washed whole blood were then analyzed for phorbol myristate acetate (PMA)-stimulated CD11b, CD35, and CD16 expressions and production of reactive oxygen intermediates (ROI), as well as phagocytosis with/without anti-CD11b antibody. Tetradecanoylphorbol Acetate 50-75 integrin subunit alpha M Homo sapiens 93-98 11073105-7 2000 The present PMA-stimulated system was inhibited by the anti-FcgammaRII mAb IV.3, the anti-CD18 mAb MEM 48, and the anti-CD11b mAb 2LPM19c but not by the anti-CD66b mAb 80H3 and N-acetyl-D-glucosamine. Tetradecanoylphorbol Acetate 12-15 integrin subunit alpha M Homo sapiens 120-125 11069028-8 2000 Moreover, the differentiation status of these Raf-responsive cells was more immature upon Raf activation as culture with the differentiation-inducing agent phorbol 12 myristate 13-acetate (PMA) and beta-estradiol resulted in decreased levels of the CD11b and CD18 integrin molecules on the cell surface. Tetradecanoylphorbol Acetate 156-187 integrin subunit alpha M Homo sapiens 249-254 11069028-8 2000 Moreover, the differentiation status of these Raf-responsive cells was more immature upon Raf activation as culture with the differentiation-inducing agent phorbol 12 myristate 13-acetate (PMA) and beta-estradiol resulted in decreased levels of the CD11b and CD18 integrin molecules on the cell surface. Tetradecanoylphorbol Acetate 189-192 integrin subunit alpha M Homo sapiens 249-254 10630309-4 2000 Phorbol 12-myristate 13-acetate and all-trans-retinoic acid, which induce differentiation in U-937 cells, up-regulated CD11b (MAC1 alpha-integrin) and CD82 and down-regulated CD71 (transferrin receptor) in a time- and dose-dependent manner. Tetradecanoylphorbol Acetate 0-31 integrin subunit alpha M Homo sapiens 119-124 10630309-4 2000 Phorbol 12-myristate 13-acetate and all-trans-retinoic acid, which induce differentiation in U-937 cells, up-regulated CD11b (MAC1 alpha-integrin) and CD82 and down-regulated CD71 (transferrin receptor) in a time- and dose-dependent manner. Tetradecanoylphorbol Acetate 0-31 integrin subunit alpha M Homo sapiens 126-136 10380902-2 1999 Because many SNARE proteins appear to be common mediators of exocytosis, we examined phorbol myristate acetate-stimulated expression of CD11b and CD69 on polymorphonuclear leukocytes (PMN) from Type 2 diabetic subjects with hypertension and microalbuminuria (D-htma), hypertension only (D-ht) or uncomplicated (D-uc), and normal controls (NC) by flow cytometry. Tetradecanoylphorbol Acetate 85-110 integrin subunit alpha M Homo sapiens 136-141 11002391-5 2000 Phenotyping of U937 cells for complement receptors (CRs) and Fcgamma receptors (FcgammaRs) showed that interferon gamma (INFgamma) increased expression of FcgammaRI, CR3 (CD11b/CD18) and CR4 (CD11c/CD18) and that phorbol-12-myristate-13-acetate (PMA) increased expression of CR4. Tetradecanoylphorbol Acetate 213-244 integrin subunit alpha M Homo sapiens 171-176 10739673-6 2000 These data indicate that serine proteases specifically mediate many of the phenotypic aspects of TPA-induced monocytic differentiation but are not involved with the induction or repression of differentiation-sensitive transcription factors and suggest that serine protease activity is required for intracellular processing of CD11b. Tetradecanoylphorbol Acetate 97-100 integrin subunit alpha M Homo sapiens 326-331 10733103-4 2000 We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC. Tetradecanoylphorbol Acetate 152-155 integrin subunit alpha M Homo sapiens 257-262 10733103-4 2000 We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC. Tetradecanoylphorbol Acetate 152-155 integrin subunit alpha M Homo sapiens 264-269 9788660-8 1998 PMNs in washed whole blood were then analyzed for phorbol myristate acetate (PMA)-stimulated CD11b, CD35, and CD16 expressions and production of reactive oxygen intermediates (ROI), as well as phagocytosis with/without anti-CD11b antibody. Tetradecanoylphorbol Acetate 77-80 integrin subunit alpha M Homo sapiens 93-98 9744516-5 1998 Simultaneous exposure to PMA and sphingosine blocked stimulation of CD11b and PKC expression without affecting growth arrest and VDR down regulation. Tetradecanoylphorbol Acetate 25-28 integrin subunit alpha M Homo sapiens 68-73 9060454-9 1997 Addition of intact specific granule membranes to the plasma membranes from PMA-treated neutrophils markedly decreased phosphorylation in both CD11b and CD18 subunits. Tetradecanoylphorbol Acetate 75-78 integrin subunit alpha M Homo sapiens 142-147 9615391-4 1998 At equimolar concentrations (10 nM), PMA, in contrast to bryostatin 1, induced cellular differentiation of U937 cells, reflected by growth inhibition, increased plastic adhesion, and expression of the monocytic differentiation marker, CD11b. Tetradecanoylphorbol Acetate 37-40 integrin subunit alpha M Homo sapiens 235-240 9566710-1 1998 We have demonstrated previously that a phosphorothioate antisense oligonucleotide to the p65 subunit of the inducible transcription factor NF-kappaB produced rapid changes in the expression of leukocyte integrin CD11b (Mo 1) and in the adhesion of dimethylsulfoxide (DMSO)-differentiated HL-60 cells stimulated by 12-O-tetradecanoylphorbol 13-acetate. Tetradecanoylphorbol Acetate 314-350 integrin subunit alpha M Homo sapiens 212-217 9160089-7 1997 Phorbol myristate acetate (PMA) induced a time- and dose-dependent up-regulation of CD11a, CD11b, CD11c, CD18 and CD54 that was inhibited by cycloheximide, suggesting a dependence on de novo protein synthesis. Tetradecanoylphorbol Acetate 0-25 integrin subunit alpha M Homo sapiens 91-96 9160089-7 1997 Phorbol myristate acetate (PMA) induced a time- and dose-dependent up-regulation of CD11a, CD11b, CD11c, CD18 and CD54 that was inhibited by cycloheximide, suggesting a dependence on de novo protein synthesis. Tetradecanoylphorbol Acetate 27-30 integrin subunit alpha M Homo sapiens 91-96 9150350-12 1997 Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta. Tetradecanoylphorbol Acetate 57-60 integrin subunit alpha M Homo sapiens 30-35 9150350-12 1997 Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta. Tetradecanoylphorbol Acetate 200-203 integrin subunit alpha M Homo sapiens 30-35 9150350-2 1997 In the present study, we prepared a karyotype of MONO-MAC-1, analysed the growth behaviour, determined the presence of differentiation-associated antigens and studied the expression and secretion of several cytokines upon stimulation with 12-O-tetradecanoyl phorbol 13-acetate (TPA) and lipopolysaccharide (LPS). Tetradecanoylphorbol Acetate 239-276 integrin subunit alpha M Homo sapiens 54-59 9596928-6 1997 U937 cells stimulated by low dosage PMA adhered with coated C 33, and the adhesion was blocked by anti-CD 11b monoclonal antibody. Tetradecanoylphorbol Acetate 36-39 integrin subunit alpha M Homo sapiens 103-109 9075429-5 1997 However, during stimulation with beta-phorbol 12-myristate 13-acetate, the increase in CD11b expression in neutrophils from patients with diabetes was significantly less than in controls. Tetradecanoylphorbol Acetate 33-69 integrin subunit alpha M Homo sapiens 87-92 9040945-8 1997 Results from these studies suggest that TPA-induced microtubule reorganization is a prerequisite for integrin vesicle translocation in U937 cells and that vesicle translocation to the plasma membrane may be a prerequisite for the transcriptional activation of cd11b and cd11c integrin genes in the early stages of monocyte differentiation. Tetradecanoylphorbol Acetate 40-43 integrin subunit alpha M Homo sapiens 260-265 8947589-7 1996 The differentiation of HL-60 cells induced by all-trans retinoic acid, dimethyl sulfoxide or phorbol-12-myristate 13-acetate was also enhanced by ethacrynic acid with increasing NBT-reducing and lysozyme activities and the expression of CD11b or CD14 surface antigen. Tetradecanoylphorbol Acetate 93-124 integrin subunit alpha M Homo sapiens 237-242 9008610-2 1997 METHODS: The expression of CD11b and L-selectin during neutrophil activation with tumor necrosis factor alpha (TNF alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), FMLP, phorbol myristate acetate (PMA), and calcium ionophore A23187 was assessed by flow cytometry. Tetradecanoylphorbol Acetate 188-213 integrin subunit alpha M Homo sapiens 27-32 9008610-2 1997 METHODS: The expression of CD11b and L-selectin during neutrophil activation with tumor necrosis factor alpha (TNF alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), FMLP, phorbol myristate acetate (PMA), and calcium ionophore A23187 was assessed by flow cytometry. Tetradecanoylphorbol Acetate 215-218 integrin subunit alpha M Homo sapiens 27-32 9332699-5 1997 However, linoleic acid and linoleic acid anilide slightly inhibited the phorbol myristate acetate (PMA)-induced expression of CD11b, which was decreased by 27 and 21% at concentrations of 100 and 1000 microM, respectively. Tetradecanoylphorbol Acetate 72-97 integrin subunit alpha M Homo sapiens 126-131 9332699-5 1997 However, linoleic acid and linoleic acid anilide slightly inhibited the phorbol myristate acetate (PMA)-induced expression of CD11b, which was decreased by 27 and 21% at concentrations of 100 and 1000 microM, respectively. Tetradecanoylphorbol Acetate 99-102 integrin subunit alpha M Homo sapiens 126-131 8764366-4 1996 Further, U-73122 suppressed interleukin-8, N-formylmethionyl-leucyl-phenylalanine and PMA-stimulated up-regulation of the beta 2-integrin, Mac-1 (CD11b/CD18), on the PMN surface (IC50 < 1.3 microM). Tetradecanoylphorbol Acetate 86-89 integrin subunit alpha M Homo sapiens 139-144 8694833-2 1996 By contrast, 1, 25 D3 increases the expression of CD11b, an early myeloid marker and enhances adherence to plastic following priming of the cells with phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 184-187 integrin subunit alpha M Homo sapiens 50-55 8764366-4 1996 Further, U-73122 suppressed interleukin-8, N-formylmethionyl-leucyl-phenylalanine and PMA-stimulated up-regulation of the beta 2-integrin, Mac-1 (CD11b/CD18), on the PMN surface (IC50 < 1.3 microM). Tetradecanoylphorbol Acetate 86-89 integrin subunit alpha M Homo sapiens 146-151 7695161-2 1995 Treatment of leukocytes with phorbol myristate acetate (PMA) caused significant increases in the expression of adhesion molecules, CD11a, CD11b, CD11c, and CD18, on the surface of the leukocytes. Tetradecanoylphorbol Acetate 29-54 integrin subunit alpha M Homo sapiens 138-143 8703375-4 1996 PMN incubated in the presence of the soluble stimuli phorbol myristate acetate(PMA, 100 ng/ml) or recombinant human C5a(rHC5a, 10(-8) M) generated significant amounts of hydrogen peroxide, increased their CD11b expression and decreased their CD16 expression. Tetradecanoylphorbol Acetate 53-78 integrin subunit alpha M Homo sapiens 205-210 8703375-4 1996 PMN incubated in the presence of the soluble stimuli phorbol myristate acetate(PMA, 100 ng/ml) or recombinant human C5a(rHC5a, 10(-8) M) generated significant amounts of hydrogen peroxide, increased their CD11b expression and decreased their CD16 expression. Tetradecanoylphorbol Acetate 79-82 integrin subunit alpha M Homo sapiens 205-210 8598475-5 1996 Studies with these cells and the RC2A myeloid cell line stimulated with tetradecanoyl phorbol acetate or FMLP indicated that the 25E11 epitope on Mac-1 did not depend on cell activation for its expression. Tetradecanoylphorbol Acetate 72-101 integrin subunit alpha M Homo sapiens 146-151 7594491-10 1995 Moreover, NIF prevented PMA-induced neutrophil adhesion to fibrinogen, a CD11b/CD18-dependent event, but produced a smaller decrease in adherence to endothelial cells, which also involves CD11a/CD18 integrins. Tetradecanoylphorbol Acetate 24-27 integrin subunit alpha M Homo sapiens 73-78 7594621-3 1995 Separated neutrophils are also more resistant than unseparated neutrophils to PMA induced upregulation of a functional epitope of CD11b. Tetradecanoylphorbol Acetate 78-81 integrin subunit alpha M Homo sapiens 130-135 8804936-8 1996 On resting AMs, the surface expression of CD11b/CD18 was significantly higher (p < 0.01) compared to resting BMs but did not increase further upon activation with fMLP, PMA or ionomycin. Tetradecanoylphorbol Acetate 172-175 integrin subunit alpha M Homo sapiens 42-47 7695161-2 1995 Treatment of leukocytes with phorbol myristate acetate (PMA) caused significant increases in the expression of adhesion molecules, CD11a, CD11b, CD11c, and CD18, on the surface of the leukocytes. Tetradecanoylphorbol Acetate 56-59 integrin subunit alpha M Homo sapiens 138-143 7695161-8 1995 The monoclonal antibodies against CD11a, CD11b, CD18, and ICAM-1 also showed inhibitory effects on the increase in intracellular fluorescence intensity of the endothelial cells exposed to PMA-stimulated leukocytes. Tetradecanoylphorbol Acetate 188-191 integrin subunit alpha M Homo sapiens 41-46 7522129-7 1994 As opposed to peripheral blood lymphocytes (PBL), phorbol 12-myristate 13-acetate (PMA) stimulation of decidual NK cells elicited a rapid increase in the numbers of CD11b-positive cells but not increased fluorescence intensity of CD11b on the stained cells. Tetradecanoylphorbol Acetate 50-81 integrin subunit alpha M Homo sapiens 165-170 7531948-5 1995 Butanol and PTX also significantly reduced the upregulation of CD11b/CD18 by f-methionyl-leucyl-phenylalanine (fMLP) and platelet-activating factor (PAF) but not by phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 192-195 integrin subunit alpha M Homo sapiens 63-68 7522129-7 1994 As opposed to peripheral blood lymphocytes (PBL), phorbol 12-myristate 13-acetate (PMA) stimulation of decidual NK cells elicited a rapid increase in the numbers of CD11b-positive cells but not increased fluorescence intensity of CD11b on the stained cells. Tetradecanoylphorbol Acetate 83-86 integrin subunit alpha M Homo sapiens 165-170 7522129-7 1994 As opposed to peripheral blood lymphocytes (PBL), phorbol 12-myristate 13-acetate (PMA) stimulation of decidual NK cells elicited a rapid increase in the numbers of CD11b-positive cells but not increased fluorescence intensity of CD11b on the stained cells. Tetradecanoylphorbol Acetate 83-86 integrin subunit alpha M Homo sapiens 230-235 7906937-6 1994 The monoclonal antibodies against CD11a, CD11b, CD18, and ICAM-1 showed almost complete inhibition of the increase in intracellular peroxide levels of the endothelial cells exposed to PMA-stimulated leukocytes. Tetradecanoylphorbol Acetate 184-187 integrin subunit alpha M Homo sapiens 41-46 8046240-0 1994 A low molecular weight phagocytosis-inhibitory factor obtained from human erythrocyte membranes specifically down-regulates Mac-1 activity on tetradecanoyl phorbol acetate-stimulated monocytic cell lines in a Ca(2+)-dependent manner. Tetradecanoylphorbol Acetate 142-171 integrin subunit alpha M Homo sapiens 124-129 8101106-7 1993 Furthermore, the p65 antisense oligomer effectively abolished an upregulation of CD11b that was produced by formyl-met-leu-phe and TPA. Tetradecanoylphorbol Acetate 131-134 integrin subunit alpha M Homo sapiens 81-86 8255104-11 1993 Cells exposed to phorbol myristate acetate (PMA) had increased expression of CD11a, CD11b, CD18, CD45RO, and HLA-DR, whereas expression of CD15 and CD30 was markedly decreased. Tetradecanoylphorbol Acetate 17-42 integrin subunit alpha M Homo sapiens 84-89 8400300-6 1993 When CD11b/CD18 expressing K562 cells were stimulated with phorbol myristate acetate (50 ng/mL) for 24 to 48 hours, these K562 cells formed dense cell:cell aggregates. Tetradecanoylphorbol Acetate 59-84 integrin subunit alpha M Homo sapiens 5-10 8287040-2 1993 12-O-Tetradecanoylphorbol-13- acetate (TPA) suppressed the expression of the erythrocytic (glycophorin A) and myelocytic (CD11b) antigens in K562-L, but increased the expression of these antigens in K562-H. TPA increased the megakaryocytic (CD61) antigens in both cells. Tetradecanoylphorbol Acetate 0-37 integrin subunit alpha M Homo sapiens 122-127 8287040-2 1993 12-O-Tetradecanoylphorbol-13- acetate (TPA) suppressed the expression of the erythrocytic (glycophorin A) and myelocytic (CD11b) antigens in K562-L, but increased the expression of these antigens in K562-H. TPA increased the megakaryocytic (CD61) antigens in both cells. Tetradecanoylphorbol Acetate 39-42 integrin subunit alpha M Homo sapiens 122-127 8105372-6 1993 This treatment resulted in the inhibition of phorbol 12-myristate 13-acetate (PMA)-induced cellular adhesion, morphological changes, and the expression of leukocyte integrin CD11b. Tetradecanoylphorbol Acetate 45-76 integrin subunit alpha M Homo sapiens 174-179 8105372-6 1993 This treatment resulted in the inhibition of phorbol 12-myristate 13-acetate (PMA)-induced cellular adhesion, morphological changes, and the expression of leukocyte integrin CD11b. Tetradecanoylphorbol Acetate 78-81 integrin subunit alpha M Homo sapiens 174-179 8376598-6 1993 Stimulation with PMA or Ionomycin resulted in full translocation of Mac-1 from secretory vesicles and gelatinase granules to the plasma membrane, and partial translocation of Mac-1 from specific granules. Tetradecanoylphorbol Acetate 17-20 integrin subunit alpha M Homo sapiens 68-73 8376598-6 1993 Stimulation with PMA or Ionomycin resulted in full translocation of Mac-1 from secretory vesicles and gelatinase granules to the plasma membrane, and partial translocation of Mac-1 from specific granules. Tetradecanoylphorbol Acetate 17-20 integrin subunit alpha M Homo sapiens 175-180 8394087-3 1993 Detailed analysis of phorbol 12-myristate 13-acetate-treated THP-1 cells showed an increased PBR expression and the rise came along with an increase of CD11a and CD11b antigens and a secretion of macrophagic cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-8. Tetradecanoylphorbol Acetate 21-52 integrin subunit alpha M Homo sapiens 162-167 1355672-8 1992 FMLP-induced neutrophil aggregation was inhibited by 39.8% +/- 11.5% and 44.8% +/- 12.3%, respectively, by MoAbs to CD18 and CD11b (P less than .0005, n = 4 for both); a similar effect was demonstrated on TPA-induced aggregation. Tetradecanoylphorbol Acetate 205-208 integrin subunit alpha M Homo sapiens 125-130 8454955-12 1993 Stimulation with receptor-independent stimuli such as phorbol myristate acetate and ionomycin induced more pronounced mobilization of Mac-1 on eosinophils, but no differences were obtained if the mobilized pool was related to their total pool. Tetradecanoylphorbol Acetate 54-79 integrin subunit alpha M Homo sapiens 134-139 3278004-3 1988 We found that phorbol myristate acetate (PMA), calcium ionophore (A23187), and FMLP caused a three- to sevenfold increase in surface expression of both CD11b (alpha M) and CD18 (beta) as assayed by binding of MAbs 60.1 (anti-CD11b) and 60.3 (anti-CD18). Tetradecanoylphorbol Acetate 14-39 integrin subunit alpha M Homo sapiens 152-157 2032553-1 1991 Treatment of neutrophils with phorbol myristate acetate (PMA) increases surface expression of CR3 (iC3b-receptor; CD11b/CD18). Tetradecanoylphorbol Acetate 30-55 integrin subunit alpha M Homo sapiens 114-119 2032553-1 1991 Treatment of neutrophils with phorbol myristate acetate (PMA) increases surface expression of CR3 (iC3b-receptor; CD11b/CD18). Tetradecanoylphorbol Acetate 57-60 integrin subunit alpha M Homo sapiens 114-119 3056960-8 1988 Phorbol myristate acetate (PMA)-induced grranulocyte adhesion to HUVE was significantly inhibited by anti-Mo1a and anti-beta, but not by anti-LFA-1a or anti-p150. Tetradecanoylphorbol Acetate 0-25 integrin subunit alpha M Homo sapiens 106-110 3056960-8 1988 Phorbol myristate acetate (PMA)-induced grranulocyte adhesion to HUVE was significantly inhibited by anti-Mo1a and anti-beta, but not by anti-LFA-1a or anti-p150. Tetradecanoylphorbol Acetate 27-30 integrin subunit alpha M Homo sapiens 106-110 2168226-3 1990 Concentrations of H7 and H8 that inhibited the 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulated upregulation of CD11b expression and activation of the respiratory burst, both augmented the effects of GM-CSF. Tetradecanoylphorbol Acetate 47-84 integrin subunit alpha M Homo sapiens 118-123 2168226-3 1990 Concentrations of H7 and H8 that inhibited the 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulated upregulation of CD11b expression and activation of the respiratory burst, both augmented the effects of GM-CSF. Tetradecanoylphorbol Acetate 86-89 integrin subunit alpha M Homo sapiens 118-123 3278004-3 1988 We found that phorbol myristate acetate (PMA), calcium ionophore (A23187), and FMLP caused a three- to sevenfold increase in surface expression of both CD11b (alpha M) and CD18 (beta) as assayed by binding of MAbs 60.1 (anti-CD11b) and 60.3 (anti-CD18). Tetradecanoylphorbol Acetate 14-39 integrin subunit alpha M Homo sapiens 225-230 3278004-3 1988 We found that phorbol myristate acetate (PMA), calcium ionophore (A23187), and FMLP caused a three- to sevenfold increase in surface expression of both CD11b (alpha M) and CD18 (beta) as assayed by binding of MAbs 60.1 (anti-CD11b) and 60.3 (anti-CD18). Tetradecanoylphorbol Acetate 41-44 integrin subunit alpha M Homo sapiens 152-157 3278004-3 1988 We found that phorbol myristate acetate (PMA), calcium ionophore (A23187), and FMLP caused a three- to sevenfold increase in surface expression of both CD11b (alpha M) and CD18 (beta) as assayed by binding of MAbs 60.1 (anti-CD11b) and 60.3 (anti-CD18). Tetradecanoylphorbol Acetate 41-44 integrin subunit alpha M Homo sapiens 225-230 3278004-5 1988 Pretreatment of neutrophils with the anion channel-blocking agent, DIDS (4,4"-diisothiocyanostilbene-2,2"-disulfonic acid), inhibited the increased surface expression of CD11b and CD18 after stimulation by PMA, A23187, or FMLP and resulted in nearly complete inhibition of neutrophil aggregation. Tetradecanoylphorbol Acetate 206-209 integrin subunit alpha M Homo sapiens 170-175