PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8947589-7	1996	The differentiation of HL-60 cells induced by all-trans retinoic acid, dimethyl sulfoxide or phorbol-12-myristate 13-acetate was also enhanced by ethacrynic acid with increasing NBT-reducing and lysozyme activities and the expression of CD11b or CD14 surface antigen.	Tetradecanoylphorbol Acetate	93-124	integrin subunit alpha M	Homo sapiens	237-242	
8764366-4	1996	Further, U-73122 suppressed interleukin-8, N-formylmethionyl-leucyl-phenylalanine and PMA-stimulated up-regulation of the beta 2-integrin, Mac-1 (CD11b/CD18), on the PMN surface (IC50 < 1.3 microM).	Tetradecanoylphorbol Acetate	86-89	integrin subunit alpha M	Homo sapiens	139-144	
8694833-2	1996	By contrast, 1, 25 D3 increases the expression of CD11b, an early myeloid marker and enhances adherence to plastic following priming of the cells with phorbol 12-myristate 13-acetate (PMA).	Tetradecanoylphorbol Acetate	184-187	integrin subunit alpha M	Homo sapiens	50-55	
8764366-4	1996	Further, U-73122 suppressed interleukin-8, N-formylmethionyl-leucyl-phenylalanine and PMA-stimulated up-regulation of the beta 2-integrin, Mac-1 (CD11b/CD18), on the PMN surface (IC50 < 1.3 microM).	Tetradecanoylphorbol Acetate	86-89	integrin subunit alpha M	Homo sapiens	146-151	
8703375-4	1996	PMN incubated in the presence of the soluble stimuli phorbol myristate acetate(PMA, 100 ng/ml) or recombinant human C5a(rHC5a, 10(-8) M) generated significant amounts of hydrogen peroxide, increased their CD11b expression and decreased their CD16 expression.	Tetradecanoylphorbol Acetate	53-78	integrin subunit alpha M	Homo sapiens	205-210	
8804936-8	1996	On resting AMs, the surface expression of CD11b/CD18 was significantly higher (p < 0.01) compared to resting BMs but did not increase further upon activation with fMLP, PMA or ionomycin.	Tetradecanoylphorbol Acetate	172-175	integrin subunit alpha M	Homo sapiens	42-47	
8703375-4	1996	PMN incubated in the presence of the soluble stimuli phorbol myristate acetate(PMA, 100 ng/ml) or recombinant human C5a(rHC5a, 10(-8) M) generated significant amounts of hydrogen peroxide, increased their CD11b expression and decreased their CD16 expression.	Tetradecanoylphorbol Acetate	79-82	integrin subunit alpha M	Homo sapiens	205-210	
8598475-5	1996	Studies with these cells and the RC2A myeloid cell line stimulated with tetradecanoyl phorbol acetate or FMLP indicated that the 25E11 epitope on Mac-1 did not depend on cell activation for its expression.	Tetradecanoylphorbol Acetate	72-101	integrin subunit alpha M	Homo sapiens	146-151	
7522129-7	1994	As opposed to peripheral blood lymphocytes (PBL), phorbol 12-myristate 13-acetate (PMA) stimulation of decidual NK cells elicited a rapid increase in the numbers of CD11b-positive cells but not increased fluorescence intensity of CD11b on the stained cells.	Tetradecanoylphorbol Acetate	50-81	integrin subunit alpha M	Homo sapiens	165-170	
7531948-5	1995	Butanol and PTX also significantly reduced the upregulation of CD11b/CD18 by f-methionyl-leucyl-phenylalanine (fMLP) and platelet-activating factor (PAF) but not by phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	192-195	integrin subunit alpha M	Homo sapiens	63-68	
7594491-10	1995	Moreover, NIF prevented PMA-induced neutrophil adhesion to fibrinogen, a CD11b/CD18-dependent event, but produced a smaller decrease in adherence to endothelial cells, which also involves CD11a/CD18 integrins.	Tetradecanoylphorbol Acetate	24-27	integrin subunit alpha M	Homo sapiens	73-78	
7594621-3	1995	Separated neutrophils are also more resistant than unseparated neutrophils to PMA induced upregulation of a functional epitope of CD11b.	Tetradecanoylphorbol Acetate	78-81	integrin subunit alpha M	Homo sapiens	130-135	
7695161-2	1995	Treatment of leukocytes with phorbol myristate acetate (PMA) caused significant increases in the expression of adhesion molecules, CD11a, CD11b, CD11c, and CD18, on the surface of the leukocytes.	Tetradecanoylphorbol Acetate	29-54	integrin subunit alpha M	Homo sapiens	138-143	
7695161-2	1995	Treatment of leukocytes with phorbol myristate acetate (PMA) caused significant increases in the expression of adhesion molecules, CD11a, CD11b, CD11c, and CD18, on the surface of the leukocytes.	Tetradecanoylphorbol Acetate	56-59	integrin subunit alpha M	Homo sapiens	138-143	
7695161-8	1995	The monoclonal antibodies against CD11a, CD11b, CD18, and ICAM-1 also showed inhibitory effects on the increase in intracellular fluorescence intensity of the endothelial cells exposed to PMA-stimulated leukocytes.	Tetradecanoylphorbol Acetate	188-191	integrin subunit alpha M	Homo sapiens	41-46	
7522129-7	1994	As opposed to peripheral blood lymphocytes (PBL), phorbol 12-myristate 13-acetate (PMA) stimulation of decidual NK cells elicited a rapid increase in the numbers of CD11b-positive cells but not increased fluorescence intensity of CD11b on the stained cells.	Tetradecanoylphorbol Acetate	83-86	integrin subunit alpha M	Homo sapiens	165-170	
7522129-7	1994	As opposed to peripheral blood lymphocytes (PBL), phorbol 12-myristate 13-acetate (PMA) stimulation of decidual NK cells elicited a rapid increase in the numbers of CD11b-positive cells but not increased fluorescence intensity of CD11b on the stained cells.	Tetradecanoylphorbol Acetate	83-86	integrin subunit alpha M	Homo sapiens	230-235	
8400300-6	1993	When CD11b/CD18 expressing K562 cells were stimulated with phorbol myristate acetate (50 ng/mL) for 24 to 48 hours, these K562 cells formed dense cell:cell aggregates.	Tetradecanoylphorbol Acetate	59-84	integrin subunit alpha M	Homo sapiens	5-10	
8046240-0	1994	A low molecular weight phagocytosis-inhibitory factor obtained from human erythrocyte membranes specifically down-regulates Mac-1 activity on tetradecanoyl phorbol acetate-stimulated monocytic cell lines in a Ca(2+)-dependent manner.	Tetradecanoylphorbol Acetate	142-171	integrin subunit alpha M	Homo sapiens	124-129	
7906937-6	1994	The monoclonal antibodies against CD11a, CD11b, CD18, and ICAM-1 showed almost complete inhibition of the increase in intracellular peroxide levels of the endothelial cells exposed to PMA-stimulated leukocytes.	Tetradecanoylphorbol Acetate	184-187	integrin subunit alpha M	Homo sapiens	41-46	
8255104-11	1993	Cells exposed to phorbol myristate acetate (PMA) had increased expression of CD11a, CD11b, CD18, CD45RO, and HLA-DR, whereas expression of CD15 and CD30 was markedly decreased.	Tetradecanoylphorbol Acetate	17-42	integrin subunit alpha M	Homo sapiens	84-89	
8454955-12	1993	Stimulation with receptor-independent stimuli such as phorbol myristate acetate and ionomycin induced more pronounced mobilization of Mac-1 on eosinophils, but no differences were obtained if the mobilized pool was related to their total pool.	Tetradecanoylphorbol Acetate	54-79	integrin subunit alpha M	Homo sapiens	134-139	
8394087-3	1993	Detailed analysis of phorbol 12-myristate 13-acetate-treated THP-1 cells showed an increased PBR expression and the rise came along with an increase of CD11a and CD11b antigens and a secretion of macrophagic cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-8.	Tetradecanoylphorbol Acetate	21-52	integrin subunit alpha M	Homo sapiens	162-167	
8101106-7	1993	Furthermore, the p65 antisense oligomer effectively abolished an upregulation of CD11b that was produced by formyl-met-leu-phe and TPA.	Tetradecanoylphorbol Acetate	131-134	integrin subunit alpha M	Homo sapiens	81-86	
8287040-2	1993	12-O-Tetradecanoylphorbol-13- acetate (TPA) suppressed the expression of the erythrocytic (glycophorin A) and myelocytic (CD11b) antigens in K562-L, but increased the expression of these antigens in K562-H. TPA increased the megakaryocytic (CD61) antigens in both cells.	Tetradecanoylphorbol Acetate	0-37	integrin subunit alpha M	Homo sapiens	122-127	
8287040-2	1993	12-O-Tetradecanoylphorbol-13- acetate (TPA) suppressed the expression of the erythrocytic (glycophorin A) and myelocytic (CD11b) antigens in K562-L, but increased the expression of these antigens in K562-H. TPA increased the megakaryocytic (CD61) antigens in both cells.	Tetradecanoylphorbol Acetate	39-42	integrin subunit alpha M	Homo sapiens	122-127	
8105372-6	1993	This treatment resulted in the inhibition of phorbol 12-myristate 13-acetate (PMA)-induced cellular adhesion, morphological changes, and the expression of leukocyte integrin CD11b.	Tetradecanoylphorbol Acetate	45-76	integrin subunit alpha M	Homo sapiens	174-179	
8105372-6	1993	This treatment resulted in the inhibition of phorbol 12-myristate 13-acetate (PMA)-induced cellular adhesion, morphological changes, and the expression of leukocyte integrin CD11b.	Tetradecanoylphorbol Acetate	78-81	integrin subunit alpha M	Homo sapiens	174-179	
8376598-6	1993	Stimulation with PMA or Ionomycin resulted in full translocation of Mac-1 from secretory vesicles and gelatinase granules to the plasma membrane, and partial translocation of Mac-1 from specific granules.	Tetradecanoylphorbol Acetate	17-20	integrin subunit alpha M	Homo sapiens	68-73	
8376598-6	1993	Stimulation with PMA or Ionomycin resulted in full translocation of Mac-1 from secretory vesicles and gelatinase granules to the plasma membrane, and partial translocation of Mac-1 from specific granules.	Tetradecanoylphorbol Acetate	17-20	integrin subunit alpha M	Homo sapiens	175-180	
1355672-8	1992	FMLP-induced neutrophil aggregation was inhibited by 39.8% +/- 11.5% and 44.8% +/- 12.3%, respectively, by MoAbs to CD18 and CD11b (P less than .0005, n = 4 for both); a similar effect was demonstrated on TPA-induced aggregation.	Tetradecanoylphorbol Acetate	205-208	integrin subunit alpha M	Homo sapiens	125-130	
2032553-1	1991	Treatment of neutrophils with phorbol myristate acetate (PMA) increases surface expression of CR3 (iC3b-receptor; CD11b/CD18).	Tetradecanoylphorbol Acetate	30-55	integrin subunit alpha M	Homo sapiens	114-119	
2032553-1	1991	Treatment of neutrophils with phorbol myristate acetate (PMA) increases surface expression of CR3 (iC3b-receptor; CD11b/CD18).	Tetradecanoylphorbol Acetate	57-60	integrin subunit alpha M	Homo sapiens	114-119	
3278004-3	1988	We found that phorbol myristate acetate (PMA), calcium ionophore (A23187), and FMLP caused a three- to sevenfold increase in surface expression of both CD11b (alpha M) and CD18 (beta) as assayed by binding of MAbs 60.1 (anti-CD11b) and 60.3 (anti-CD18).	Tetradecanoylphorbol Acetate	14-39	integrin subunit alpha M	Homo sapiens	152-157	
3056960-8	1988	Phorbol myristate acetate (PMA)-induced grranulocyte adhesion to HUVE was significantly inhibited by anti-Mo1a and anti-beta, but not by anti-LFA-1a or anti-p150.	Tetradecanoylphorbol Acetate	0-25	integrin subunit alpha M	Homo sapiens	106-110	
3056960-8	1988	Phorbol myristate acetate (PMA)-induced grranulocyte adhesion to HUVE was significantly inhibited by anti-Mo1a and anti-beta, but not by anti-LFA-1a or anti-p150.	Tetradecanoylphorbol Acetate	27-30	integrin subunit alpha M	Homo sapiens	106-110	
2168226-3	1990	Concentrations of H7 and H8 that inhibited the 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulated upregulation of CD11b expression and activation of the respiratory burst, both augmented the effects of GM-CSF.	Tetradecanoylphorbol Acetate	47-84	integrin subunit alpha M	Homo sapiens	118-123	
2168226-3	1990	Concentrations of H7 and H8 that inhibited the 12-O-tetradecanoyl-phorbol-13-acetate (TPA) stimulated upregulation of CD11b expression and activation of the respiratory burst, both augmented the effects of GM-CSF.	Tetradecanoylphorbol Acetate	86-89	integrin subunit alpha M	Homo sapiens	118-123	
3278004-3	1988	We found that phorbol myristate acetate (PMA), calcium ionophore (A23187), and FMLP caused a three- to sevenfold increase in surface expression of both CD11b (alpha M) and CD18 (beta) as assayed by binding of MAbs 60.1 (anti-CD11b) and 60.3 (anti-CD18).	Tetradecanoylphorbol Acetate	14-39	integrin subunit alpha M	Homo sapiens	225-230	
3278004-3	1988	We found that phorbol myristate acetate (PMA), calcium ionophore (A23187), and FMLP caused a three- to sevenfold increase in surface expression of both CD11b (alpha M) and CD18 (beta) as assayed by binding of MAbs 60.1 (anti-CD11b) and 60.3 (anti-CD18).	Tetradecanoylphorbol Acetate	41-44	integrin subunit alpha M	Homo sapiens	152-157	
3278004-3	1988	We found that phorbol myristate acetate (PMA), calcium ionophore (A23187), and FMLP caused a three- to sevenfold increase in surface expression of both CD11b (alpha M) and CD18 (beta) as assayed by binding of MAbs 60.1 (anti-CD11b) and 60.3 (anti-CD18).	Tetradecanoylphorbol Acetate	41-44	integrin subunit alpha M	Homo sapiens	225-230	
3278004-5	1988	Pretreatment of neutrophils with the anion channel-blocking agent, DIDS (4,4"-diisothiocyanostilbene-2,2"-disulfonic acid), inhibited the increased surface expression of CD11b and CD18 after stimulation by PMA, A23187, or FMLP and resulted in nearly complete inhibition of neutrophil aggregation.	Tetradecanoylphorbol Acetate	206-209	integrin subunit alpha M	Homo sapiens	170-175	
27257341-4	2016	Of the four polyphenols tested, CAPE significantly suppressed the 12-O-tetradecanoylphorbol 13-acetate (TPA)-elicited expression of cluster for differentiation (CD) 11b, 14, and 36, and this was accompanied by the inhibition of THP-1 cell adhesion to HUVEC.	Tetradecanoylphorbol Acetate	66-102	integrin subunit alpha M	Homo sapiens	132-168	
27257341-4	2016	Of the four polyphenols tested, CAPE significantly suppressed the 12-O-tetradecanoylphorbol 13-acetate (TPA)-elicited expression of cluster for differentiation (CD) 11b, 14, and 36, and this was accompanied by the inhibition of THP-1 cell adhesion to HUVEC.	Tetradecanoylphorbol Acetate	104-107	integrin subunit alpha M	Homo sapiens	132-168	
26414495-7	2015	Production of reactive oxygen species (ROS) induced by PMA (126.7 +- 2.1%) was markedly attenuated by curcumin, DMC, and BDMC to 99.5 +- 7.8%, 87.8 +- 8.2%, and 89.8 +- 7.6%, respectively, resulting in the down-regulation of CD11b and MMP-9 expression.	Tetradecanoylphorbol Acetate	55-58	integrin subunit alpha M	Homo sapiens	225-230	
24962779-6	2014	In a DMBA/TPA-induced mouse skin tumor model, inhibition of Rac1 activity and depletion of CD11b+Gr1+ cells resulted in significant tumor formation.	Tetradecanoylphorbol Acetate	10-13	integrin subunit alpha M	Homo sapiens	91-96	
26372376-6	2015	Firstly, AgNPs inhibit phorbol 12-myristate 13-acetate (PMA)-induced monocyte differentiation by down-regulating both expression of surface marker CD11b and response to lipopolysaccharide (LPS) stimulation.	Tetradecanoylphorbol Acetate	56-59	integrin subunit alpha M	Homo sapiens	147-152	
25130808-10	2014	The cells treated with both TPA and As2O3 expressed far more CD11b antigens compared with cells exposed to As2O3 alone.	Tetradecanoylphorbol Acetate	28-31	integrin subunit alpha M	Homo sapiens	61-66	
24962779-7	2014	TPA induced recruitment of CD11b+Gr1+ cells into dermis; however, Rac1 inhibitor abolished this recruitment.	Tetradecanoylphorbol Acetate	0-3	integrin subunit alpha M	Homo sapiens	27-32	
23216989-7	2012	In contrast, PMA-induced THP-1 differentiation toward monocytic cells expressed CD11b+, and CD14+, but not CD123, and revealed exclusively IL-12 expression while stimulated by dengue-2.	Tetradecanoylphorbol Acetate	13-16	integrin subunit alpha M	Homo sapiens	80-85	
24985180-9	2014	Cells treated with both TPA and As2O3 expressed more CD11b antigens compared with the cells exposed to As2O3 alone.	Tetradecanoylphorbol Acetate	24-27	integrin subunit alpha M	Homo sapiens	53-58	
23434434-9	2013	Physostigmine, in the concentration range tested, suppressed the expression of CD11b following stimulation with PMA not significantly (human PMN: control: 63.1+-10.7 vs. 97 muM physostigmine: 49.9+-12.8 MESF, p=n.s.).	Tetradecanoylphorbol Acetate	112-115	integrin subunit alpha M	Homo sapiens	79-84	
23490067-7	2013	AA clearly increased TPA-induced HL-60 cell differentiation, as evidenced by a marked increase in CD11b expression, which was inhibited by NAC and PD98059 addition.	Tetradecanoylphorbol Acetate	21-24	integrin subunit alpha M	Homo sapiens	98-103	
21804018-4	2011	Moreover, PMA-induced IL-1beta production was significantly reduced in the presence of TLR2, TLR4, and CD11b Abs.	Tetradecanoylphorbol Acetate	10-13	integrin subunit alpha M	Homo sapiens	103-108	
22607136-1	2012	Previous work has demonstrated that phorbol ester (TPA)-induced adherence of human U937 myeloid leukemia cells can be blocked upon down-modulation of the beta2-integrin CD11b after stable transfection of U937 cells with a pMTH1 vector-containing the CD11b gene in antisense orientation (asCD11b-U937) [Otte et al., (2011)].	Tetradecanoylphorbol Acetate	51-54	integrin subunit alpha M	Homo sapiens	169-174	
22607136-1	2012	Previous work has demonstrated that phorbol ester (TPA)-induced adherence of human U937 myeloid leukemia cells can be blocked upon down-modulation of the beta2-integrin CD11b after stable transfection of U937 cells with a pMTH1 vector-containing the CD11b gene in antisense orientation (asCD11b-U937) [Otte et al., (2011)].	Tetradecanoylphorbol Acetate	51-54	integrin subunit alpha M	Homo sapiens	250-255	
21336564-4	2011	Rapamycin potentiated differentiation of ATRA-treated NB4 cells, but the combination of rapamycin and LY 294002 inhibited the expression of CD11b in both ATRA- and phorbol myristate acetate (PMA)-stimulated cells more than PI3K inhibitor alone.	Tetradecanoylphorbol Acetate	164-189	integrin subunit alpha M	Homo sapiens	140-145	
21336564-4	2011	Rapamycin potentiated differentiation of ATRA-treated NB4 cells, but the combination of rapamycin and LY 294002 inhibited the expression of CD11b in both ATRA- and phorbol myristate acetate (PMA)-stimulated cells more than PI3K inhibitor alone.	Tetradecanoylphorbol Acetate	191-194	integrin subunit alpha M	Homo sapiens	140-145	
17826795-12	2007	In experiment 2, GLN increased expression of CD11b and reactive oxygen intermediate with phorbol myristate acetate, compared with controls.	Tetradecanoylphorbol Acetate	89-114	integrin subunit alpha M	Homo sapiens	45-50	
18617650-5	2008	Cyclodextrin, but not cyclodextrin/cholesterol complex, also inhibited PMA-induced CD11b activation implicating cholesterol efflux as the main mechanism.	Tetradecanoylphorbol Acetate	71-74	integrin subunit alpha M	Homo sapiens	83-88	
17398109-6	2007	RESULTS: Patients with low levels of preoperative basal neutrophil CD11b expression had the greatest increase in CD11b following phorbol-12-myristate-13-acetate stimulation.	Tetradecanoylphorbol Acetate	129-160	integrin subunit alpha M	Homo sapiens	67-72	
17398109-6	2007	RESULTS: Patients with low levels of preoperative basal neutrophil CD11b expression had the greatest increase in CD11b following phorbol-12-myristate-13-acetate stimulation.	Tetradecanoylphorbol Acetate	129-160	integrin subunit alpha M	Homo sapiens	113-118	
16374778-6	2006	PMA, which mimics diacylglycerol (DAG) as an activator of cPKC, novel-PKC (nPKC), and non-PKC DAG-driven molecule(s), produced a dose-dependent dual effect on phagocytosis by CR3/MAC-1 and SRAI/II, i.e., augmentation at low concentrations and inhibition at high concentrations.	Tetradecanoylphorbol Acetate	0-3	integrin subunit alpha M	Homo sapiens	179-184	
16374778-7	2006	Inhibition of phagocytosis by CR3/MAC-1 was enhanced by combining inhibiting concentrations of PMA with PKC inhibitors Go-6976 or Ro-318220, suggesting inhibition by PMA/DAG-driven non-PKC molecule(s).	Tetradecanoylphorbol Acetate	95-98	integrin subunit alpha M	Homo sapiens	34-39	
15620108-6	2004	The fluorescence of CD18 and CD11b reappeared on the cell membrane 1 h after re-treatment with PMA, suggesting the recycling of non-degraded Mac-1.	Tetradecanoylphorbol Acetate	95-98	integrin subunit alpha M	Homo sapiens	29-34	
16228063-0	2005	Mechanism of CD11b down-regulation from phorbol myristate acetate stimulated polymorphonuclear neutrophils.	Tetradecanoylphorbol Acetate	40-65	integrin subunit alpha M	Homo sapiens	13-18	
16228063-1	2005	OBJECTIVE: To investigate the mechanism of CD11b down-regulation in phorbol myristate acetate (PMA) stimulated polymorphonuclear leukocytes (PMN).	Tetradecanoylphorbol Acetate	68-93	integrin subunit alpha M	Homo sapiens	43-48	
16228063-1	2005	OBJECTIVE: To investigate the mechanism of CD11b down-regulation in phorbol myristate acetate (PMA) stimulated polymorphonuclear leukocytes (PMN).	Tetradecanoylphorbol Acetate	95-98	integrin subunit alpha M	Homo sapiens	43-48	
16111532-4	2005	TPA induced the following antigens in decreasing order of the change: CD11c, CD9, CD11b, CD54, CD38, CD45RO and CD66c, with repression of CD4, CD117, CD95, CD71 and CD64.	Tetradecanoylphorbol Acetate	0-3	integrin subunit alpha M	Homo sapiens	82-87	
15620108-6	2004	The fluorescence of CD18 and CD11b reappeared on the cell membrane 1 h after re-treatment with PMA, suggesting the recycling of non-degraded Mac-1.	Tetradecanoylphorbol Acetate	95-98	integrin subunit alpha M	Homo sapiens	141-146	
12960243-4	2003	Immunoprecipitation experiments using plasma membranes of phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils revealed coimmunoprecipitation of PR3 with CD11b/CD18, indicating their location in the same complex.	Tetradecanoylphorbol Acetate	91-94	integrin subunit alpha M	Homo sapiens	162-167	
12689660-11	2003	CD11b(+)Gr-1(+) cells isolated from the blood or spleen of TCDD-treated mice produced up to fivefold higher levels of superoxide following PMA stimulation when compared with cells from vehicle-treated mice.	Tetradecanoylphorbol Acetate	139-142	integrin subunit alpha M	Homo sapiens	0-5	
12960243-4	2003	Immunoprecipitation experiments using plasma membranes of phorbol 12-myristate 13-acetate (PMA)-stimulated neutrophils revealed coimmunoprecipitation of PR3 with CD11b/CD18, indicating their location in the same complex.	Tetradecanoylphorbol Acetate	58-89	integrin subunit alpha M	Homo sapiens	162-167	
12225365-2	2002	Phorbol 12-myristate 13-acetate (PMA) caused time- and concentration-dependent adhesion of AML cells to plated bovine serum albumin (BSA), which was blocked by anti-CD11b or anti-CD18 monoclonal antibodies (mAb) directed against beta2-integrin.	Tetradecanoylphorbol Acetate	0-31	integrin subunit alpha M	Homo sapiens	165-170	
12225365-2	2002	Phorbol 12-myristate 13-acetate (PMA) caused time- and concentration-dependent adhesion of AML cells to plated bovine serum albumin (BSA), which was blocked by anti-CD11b or anti-CD18 monoclonal antibodies (mAb) directed against beta2-integrin.	Tetradecanoylphorbol Acetate	33-36	integrin subunit alpha M	Homo sapiens	165-170	
12061815-2	2002	Exposure of U937 cells to 1 mM SB and 1 nM PMA (24 h) markedly induced caspase activation and apoptosis, events accompanied by impaired differentiation induction (e.g., reduced plastic adherence and diminished expression of CD11b) as well as reduced clonogenic survival.	Tetradecanoylphorbol Acetate	43-46	integrin subunit alpha M	Homo sapiens	224-229	
11514958-4	2001	Basal and phorbol myristate acetate (PMA)-stimulated oxidative burst and CD11b expression were determined using dihydrorhodamine 123 and phycoerythrin (PE)-conjugated anti-CD11b monoclonal antibodies.	Tetradecanoylphorbol Acetate	37-40	integrin subunit alpha M	Homo sapiens	73-78	
11893077-4	2002	Expression of the CD11b antisense gene in stably transfected U937 cells (as-CD11b cells) resulted in an attenuated response to TPA.	Tetradecanoylphorbol Acetate	127-130	integrin subunit alpha M	Homo sapiens	18-23	
11893077-4	2002	Expression of the CD11b antisense gene in stably transfected U937 cells (as-CD11b cells) resulted in an attenuated response to TPA.	Tetradecanoylphorbol Acetate	127-130	integrin subunit alpha M	Homo sapiens	76-81	
11893077-5	2002	As-CD11b cells demonstrated poor adhesion to solid substrate upon TPA treatment in contrast to U937 control cells.	Tetradecanoylphorbol Acetate	66-69	integrin subunit alpha M	Homo sapiens	3-8	
11893077-9	2002	According to the failure to undergo a monocytic differentiation program, TPA treatment of as-CD11b cells resulted in a progressively increasing amount of apoptotic cells whereas the differentiated population of U937 control cells remained alive.	Tetradecanoylphorbol Acetate	73-76	integrin subunit alpha M	Homo sapiens	93-98	
11587160-9	2001	Stimulation with PMA caused more rapid activation in EHT neutrophils with expression of CD11b, followed rapidly by exocytosis of primary granules.	Tetradecanoylphorbol Acetate	17-20	integrin subunit alpha M	Homo sapiens	88-93	
11514958-4	2001	Basal and phorbol myristate acetate (PMA)-stimulated oxidative burst and CD11b expression were determined using dihydrorhodamine 123 and phycoerythrin (PE)-conjugated anti-CD11b monoclonal antibodies.	Tetradecanoylphorbol Acetate	37-40	integrin subunit alpha M	Homo sapiens	172-177	
10739673-6	2000	These data indicate that serine proteases specifically mediate many of the phenotypic aspects of TPA-induced monocytic differentiation but are not involved with the induction or repression of differentiation-sensitive transcription factors and suggest that serine protease activity is required for intracellular processing of CD11b.	Tetradecanoylphorbol Acetate	97-100	integrin subunit alpha M	Homo sapiens	326-331	
11287316-3	2001	Phosphorylation of p92 was inducible when Mac-1 was activated by phorbol 12-myristate 13-acetate, the beta(2)-specific activating antibody CBR LFA-1/2, or interleukin-8 (77 amino acids).	Tetradecanoylphorbol Acetate	65-96	integrin subunit alpha M	Homo sapiens	42-47	
11073105-7	2000	The present PMA-stimulated system was inhibited by the anti-FcgammaRII mAb IV.3, the anti-CD18 mAb MEM 48, and the anti-CD11b mAb 2LPM19c but not by the anti-CD66b mAb 80H3 and N-acetyl-D-glucosamine.	Tetradecanoylphorbol Acetate	12-15	integrin subunit alpha M	Homo sapiens	120-125	
11069028-8	2000	Moreover, the differentiation status of these Raf-responsive cells was more immature upon Raf activation as culture with the differentiation-inducing agent phorbol 12 myristate 13-acetate (PMA) and beta-estradiol resulted in decreased levels of the CD11b and CD18 integrin molecules on the cell surface.	Tetradecanoylphorbol Acetate	156-187	integrin subunit alpha M	Homo sapiens	249-254	
11069028-8	2000	Moreover, the differentiation status of these Raf-responsive cells was more immature upon Raf activation as culture with the differentiation-inducing agent phorbol 12 myristate 13-acetate (PMA) and beta-estradiol resulted in decreased levels of the CD11b and CD18 integrin molecules on the cell surface.	Tetradecanoylphorbol Acetate	189-192	integrin subunit alpha M	Homo sapiens	249-254	
11002391-5	2000	Phenotyping of U937 cells for complement receptors (CRs) and Fcgamma receptors (FcgammaRs) showed that interferon gamma (INFgamma) increased expression of FcgammaRI, CR3 (CD11b/CD18) and CR4 (CD11c/CD18) and that phorbol-12-myristate-13-acetate (PMA) increased expression of CR4.	Tetradecanoylphorbol Acetate	213-244	integrin subunit alpha M	Homo sapiens	171-176	
10733103-4	2000	We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC.	Tetradecanoylphorbol Acetate	152-155	integrin subunit alpha M	Homo sapiens	257-262	
10733103-4	2000	We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC.	Tetradecanoylphorbol Acetate	152-155	integrin subunit alpha M	Homo sapiens	264-269	
9615391-4	1998	At equimolar concentrations (10 nM), PMA, in contrast to bryostatin 1, induced cellular differentiation of U937 cells, reflected by growth inhibition, increased plastic adhesion, and expression of the monocytic differentiation marker, CD11b.	Tetradecanoylphorbol Acetate	37-40	integrin subunit alpha M	Homo sapiens	235-240	
10630309-4	2000	Phorbol 12-myristate 13-acetate and all-trans-retinoic acid, which induce differentiation in U-937 cells, up-regulated CD11b (MAC1 alpha-integrin) and CD82 and down-regulated CD71 (transferrin receptor) in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	0-31	integrin subunit alpha M	Homo sapiens	119-124	
10630309-4	2000	Phorbol 12-myristate 13-acetate and all-trans-retinoic acid, which induce differentiation in U-937 cells, up-regulated CD11b (MAC1 alpha-integrin) and CD82 and down-regulated CD71 (transferrin receptor) in a time- and dose-dependent manner.	Tetradecanoylphorbol Acetate	0-31	integrin subunit alpha M	Homo sapiens	126-136	
9744516-5	1998	Simultaneous exposure to PMA and sphingosine blocked stimulation of CD11b and PKC expression without affecting growth arrest and VDR down regulation.	Tetradecanoylphorbol Acetate	25-28	integrin subunit alpha M	Homo sapiens	68-73	
10380902-2	1999	Because many SNARE proteins appear to be common mediators of exocytosis, we examined phorbol myristate acetate-stimulated expression of CD11b and CD69 on polymorphonuclear leukocytes (PMN) from Type 2 diabetic subjects with hypertension and microalbuminuria (D-htma), hypertension only (D-ht) or uncomplicated (D-uc), and normal controls (NC) by flow cytometry.	Tetradecanoylphorbol Acetate	85-110	integrin subunit alpha M	Homo sapiens	136-141	
9788660-8	1998	PMNs in washed whole blood were then analyzed for phorbol myristate acetate (PMA)-stimulated CD11b, CD35, and CD16 expressions and production of reactive oxygen intermediates (ROI), as well as phagocytosis with/without anti-CD11b antibody.	Tetradecanoylphorbol Acetate	50-75	integrin subunit alpha M	Homo sapiens	93-98	
9788660-8	1998	PMNs in washed whole blood were then analyzed for phorbol myristate acetate (PMA)-stimulated CD11b, CD35, and CD16 expressions and production of reactive oxygen intermediates (ROI), as well as phagocytosis with/without anti-CD11b antibody.	Tetradecanoylphorbol Acetate	77-80	integrin subunit alpha M	Homo sapiens	93-98	
9566710-1	1998	We have demonstrated previously that a phosphorothioate antisense oligonucleotide to the p65 subunit of the inducible transcription factor NF-kappaB produced rapid changes in the expression of leukocyte integrin CD11b (Mo 1) and in the adhesion of dimethylsulfoxide (DMSO)-differentiated HL-60 cells stimulated by 12-O-tetradecanoylphorbol 13-acetate.	Tetradecanoylphorbol Acetate	314-350	integrin subunit alpha M	Homo sapiens	212-217	
9150350-12	1997	Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta.	Tetradecanoylphorbol Acetate	57-60	integrin subunit alpha M	Homo sapiens	30-35	
9160089-7	1997	Phorbol myristate acetate (PMA) induced a time- and dose-dependent up-regulation of CD11a, CD11b, CD11c, CD18 and CD54 that was inhibited by cycloheximide, suggesting a dependence on de novo protein synthesis.	Tetradecanoylphorbol Acetate	0-25	integrin subunit alpha M	Homo sapiens	91-96	
9160089-7	1997	Phorbol myristate acetate (PMA) induced a time- and dose-dependent up-regulation of CD11a, CD11b, CD11c, CD18 and CD54 that was inhibited by cycloheximide, suggesting a dependence on de novo protein synthesis.	Tetradecanoylphorbol Acetate	27-30	integrin subunit alpha M	Homo sapiens	91-96	
9150350-2	1997	In the present study, we prepared a karyotype of MONO-MAC-1, analysed the growth behaviour, determined the presence of differentiation-associated antigens and studied the expression and secretion of several cytokines upon stimulation with 12-O-tetradecanoyl phorbol 13-acetate (TPA) and lipopolysaccharide (LPS).	Tetradecanoylphorbol Acetate	239-276	integrin subunit alpha M	Homo sapiens	54-59	
9150350-12	1997	Similarly, incubation of MONO-MAC-1, simultaneously with TPA and LPS, led to granulocyte macrophage CSF (GM-CSF) and interleukin-1beta (IL-1beta)secretion, while both stimulators alone had almost no (TPA) or only a weak (LPS) effect on the secretion of GM-CSF and IL-1beta.	Tetradecanoylphorbol Acetate	200-203	integrin subunit alpha M	Homo sapiens	30-35	
9332699-5	1997	However, linoleic acid and linoleic acid anilide slightly inhibited the phorbol myristate acetate (PMA)-induced expression of CD11b, which was decreased by 27 and 21% at concentrations of 100 and 1000 microM, respectively.	Tetradecanoylphorbol Acetate	72-97	integrin subunit alpha M	Homo sapiens	126-131	
9596928-6	1997	U937 cells stimulated by low dosage PMA adhered with coated C 33, and the adhesion was blocked by anti-CD 11b monoclonal antibody.	Tetradecanoylphorbol Acetate	36-39	integrin subunit alpha M	Homo sapiens	103-109	
9075429-5	1997	However, during stimulation with beta-phorbol 12-myristate 13-acetate, the increase in CD11b expression in neutrophils from patients with diabetes was significantly less than in controls.	Tetradecanoylphorbol Acetate	33-69	integrin subunit alpha M	Homo sapiens	87-92	
9060454-9	1997	Addition of intact specific granule membranes to the plasma membranes from PMA-treated neutrophils markedly decreased phosphorylation in both CD11b and CD18 subunits.	Tetradecanoylphorbol Acetate	75-78	integrin subunit alpha M	Homo sapiens	142-147	
9040945-8	1997	Results from these studies suggest that TPA-induced microtubule reorganization is a prerequisite for integrin vesicle translocation in U937 cells and that vesicle translocation to the plasma membrane may be a prerequisite for the transcriptional activation of cd11b and cd11c integrin genes in the early stages of monocyte differentiation.	Tetradecanoylphorbol Acetate	40-43	integrin subunit alpha M	Homo sapiens	260-265	
9008610-2	1997	METHODS: The expression of CD11b and L-selectin during neutrophil activation with tumor necrosis factor alpha (TNF alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), FMLP, phorbol myristate acetate (PMA), and calcium ionophore A23187 was assessed by flow cytometry.	Tetradecanoylphorbol Acetate	188-213	integrin subunit alpha M	Homo sapiens	27-32	
9008610-2	1997	METHODS: The expression of CD11b and L-selectin during neutrophil activation with tumor necrosis factor alpha (TNF alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), FMLP, phorbol myristate acetate (PMA), and calcium ionophore A23187 was assessed by flow cytometry.	Tetradecanoylphorbol Acetate	215-218	integrin subunit alpha M	Homo sapiens	27-32	
9332699-5	1997	However, linoleic acid and linoleic acid anilide slightly inhibited the phorbol myristate acetate (PMA)-induced expression of CD11b, which was decreased by 27 and 21% at concentrations of 100 and 1000 microM, respectively.	Tetradecanoylphorbol Acetate	99-102	integrin subunit alpha M	Homo sapiens	126-131