PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34488927-9 2022 In addition, in phorbol 12-myristate 13-acetate (PMA)-treated THP-1 macrophages, PN-101 attenuated LPS-induced increase production of pro-inflammatory cytokines. Tetradecanoylphorbol Acetate 49-52 GLI family zinc finger 2 Homo sapiens 62-67 34632188-8 2021 In conclusion, 1,4-naphthoquinone is an effective inhibitor of IRAK1 kinases and their mediated inflammatory cytokines production in LPS-stimulated PMA-induced human THP-1 macrophages. Tetradecanoylphorbol Acetate 148-151 GLI family zinc finger 2 Homo sapiens 166-171 34681720-3 2021 THP-1 monocytes were differentiated with phorbol 12-myristate 13-acetate (PMA) into macrophages and (i) the expression of selenoproteins, (ii) differentiation markers, (iii) the activity of NF-kappaB and NRF2, as well as (iv) lipid mediator profiles were analyzed. Tetradecanoylphorbol Acetate 74-77 GLI family zinc finger 2 Homo sapiens 0-5 34439276-6 2021 We found that phorbol myristate acetate-induced THP-1 macrophages took up EVs-miR-21-5p from EC109 or EC9706 cells and were transformed into M2 macrophages. Tetradecanoylphorbol Acetate 14-39 GLI family zinc finger 2 Homo sapiens 48-53 35572500-5 2022 To explore the roles and mechanism of TIPE2 in M1 polarization of macrophages, THP-1 monocytes stimulated with phorbol-12-myristate-13-acetate, were used as a model of undifferentiated (M0) macrophages, and M0 macrophages were treated with lipopolysaccharide to induce M1 macrophages. Tetradecanoylphorbol Acetate 111-142 GLI family zinc finger 2 Homo sapiens 79-84 34234780-0 2021 Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation. Tetradecanoylphorbol Acetate 77-108 GLI family zinc finger 2 Homo sapiens 118-123 35150402-5 2022 Human THP-1 monocyte was differentiated into macrophages with phorbol myristate acetate, which were further identified by transmission electron microscopy and western blot. Tetradecanoylphorbol Acetate 62-87 GLI family zinc finger 2 Homo sapiens 6-11 33925858-7 2021 THP-1 monocytes were differentiated into macrophages by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) and co-treatment with 0.1 mg/mL CNDs. Tetradecanoylphorbol Acetate 71-107 GLI family zinc finger 2 Homo sapiens 0-5 2606902-1 1989 The human monocyte-like cell line, THP-1, differentiated into macrophage-like cells on the addition of a phorbol ester, 12-O-tetradecanoyl-phorbol-13-acetate. Tetradecanoylphorbol Acetate 120-157 GLI family zinc finger 2 Homo sapiens 35-40 2801310-3 1989 In the present study, THP-1 cells "primed" by 1.6 microM phorbol 12-myristate-13-acetate (TPA) for 4 hr demonstrated a dose- and time-dependent release of IL-1 beta and TNF upon activation by 20 micrograms/ml LPS. Tetradecanoylphorbol Acetate 57-88 GLI family zinc finger 2 Homo sapiens 22-27 2801310-3 1989 In the present study, THP-1 cells "primed" by 1.6 microM phorbol 12-myristate-13-acetate (TPA) for 4 hr demonstrated a dose- and time-dependent release of IL-1 beta and TNF upon activation by 20 micrograms/ml LPS. Tetradecanoylphorbol Acetate 90-93 GLI family zinc finger 2 Homo sapiens 22-27 3401441-1 1988 Stimulation of the macrophage-like cell line THP-1 with the phorbol ester phorbol 12-myristate 13-acetate (PMA) resulted in differentiation into cells with many features of macrophages. Tetradecanoylphorbol Acetate 74-105 GLI family zinc finger 2 Homo sapiens 45-50 3401441-1 1988 Stimulation of the macrophage-like cell line THP-1 with the phorbol ester phorbol 12-myristate 13-acetate (PMA) resulted in differentiation into cells with many features of macrophages. Tetradecanoylphorbol Acetate 107-110 GLI family zinc finger 2 Homo sapiens 45-50 2831271-3 1988 However, THP-1, a monocytic cell line, could be infected by HCMV with a full cycle of replication after treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), which produced differentiation of the cell line into cells with characteristics of mature macrophages. Tetradecanoylphorbol Acetate 119-156 GLI family zinc finger 2 Homo sapiens 9-14 2831271-3 1988 However, THP-1, a monocytic cell line, could be infected by HCMV with a full cycle of replication after treatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), which produced differentiation of the cell line into cells with characteristics of mature macrophages. Tetradecanoylphorbol Acetate 158-161 GLI family zinc finger 2 Homo sapiens 9-14 2957441-8 1987 LPS also inhibited Fc receptor expression on the human myelomonocytic cell line THP-1 after induction with IFN-gamma or phorbol myristate acetate alone or with both agents together. Tetradecanoylphorbol Acetate 120-145 GLI family zinc finger 2 Homo sapiens 80-85 2946400-3 1986 The number of cells with the ability to reduce nitroblue tetrazolium increased in the TPA-treated cell lines HL-60, ML-3, THP-1, and U-937, whereas the cell lines KG-1 and KLM-2 remained nitroblue tetrazolium negative. Tetradecanoylphorbol Acetate 86-89 GLI family zinc finger 2 Homo sapiens 122-127 3918210-1 1985 A cloned subline of the human monocytic leukemia cell line, THP-1, was induced to produce high levels of cytotoxic activity following an 18-hour phorbol myristate acetate (CAS: 16561-29-8) stimulation in vitro. Tetradecanoylphorbol Acetate 145-170 GLI family zinc finger 2 Homo sapiens 60-65 34013580-2 2021 METHODOLOGY: The human monocyte cell line (THP1) was differentiated into macrophages by exposure to phorbol myristate acetate (PMA) and the cultures were inoculated with E. faecalis for up to 48 h. At three time points- 90 min, 24 h, and 48 h after inoculation, the macrophages and their supernatants were examined. Tetradecanoylphorbol Acetate 100-125 GLI family zinc finger 2 Homo sapiens 43-47 34013580-2 2021 METHODOLOGY: The human monocyte cell line (THP1) was differentiated into macrophages by exposure to phorbol myristate acetate (PMA) and the cultures were inoculated with E. faecalis for up to 48 h. At three time points- 90 min, 24 h, and 48 h after inoculation, the macrophages and their supernatants were examined. Tetradecanoylphorbol Acetate 127-130 GLI family zinc finger 2 Homo sapiens 43-47 33933922-2 2021 DESIGN: THP-1 monocytes were maintained in RPMI medium and transformed into M0 macrophages using Phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 97-128 GLI family zinc finger 2 Homo sapiens 8-13 33933922-2 2021 DESIGN: THP-1 monocytes were maintained in RPMI medium and transformed into M0 macrophages using Phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 130-133 GLI family zinc finger 2 Homo sapiens 8-13 2482322-1 1989 Human monocytic cell line THP-1 incubated with as little as 10 ng/ml of phorbol myristate acetate bound and metabolized 1-2 micrograms of Ac-LDL over a 5-h period. Tetradecanoylphorbol Acetate 72-97 GLI family zinc finger 2 Homo sapiens 26-31 2765502-2 1989 Induction of LPL in THP-1 cells appears to be mediated by PKC since it was affected by both phorbol 12-myristate 13-acetate (PMA) and a diacylglycerol analogue. Tetradecanoylphorbol Acetate 92-123 GLI family zinc finger 2 Homo sapiens 20-25 2765502-2 1989 Induction of LPL in THP-1 cells appears to be mediated by PKC since it was affected by both phorbol 12-myristate 13-acetate (PMA) and a diacylglycerol analogue. Tetradecanoylphorbol Acetate 125-128 GLI family zinc finger 2 Homo sapiens 20-25 3263853-1 1988 The acute monocytic leukemia cell line THP-1 secretes predominantly IL-1 beta after treatment with bacterial lipopolysaccharide and tumour promoting phorbol ester (PMA). Tetradecanoylphorbol Acetate 164-167 GLI family zinc finger 2 Homo sapiens 39-44 2842422-5 1988 Addition of RA or the tumor promoter, phorbol 12-myristic 13-acetate (PMA), to HPBM or THP-1 cells resulted in significant increases in 5NT activity with opposite effects on ADA activity. Tetradecanoylphorbol Acetate 70-73 GLI family zinc finger 2 Homo sapiens 87-92 3165051-6 1988 In contrast, both PDGF-1 and PDGF-2 transcripts were detected in HL-60 cells and monocytes induced with TPA, while only PDGF-1 mRNA was found in TPA-treated THP-1 cells. Tetradecanoylphorbol Acetate 145-148 GLI family zinc finger 2 Homo sapiens 157-162 3267209-2 1988 The protein, designated erythroid differentiation factor (EDF), was found in the culture fluid of human THP-1 cells that had been treated with phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 143-174 GLI family zinc finger 2 Homo sapiens 104-109 3470005-2 1987 The protein, called Erythroid Differentiation Factor (EDF), was found in a 4 day culture of THP-1 cells performed in the presence of 4 beta-phorbol 12-myristate 13-acetate(PMA). Tetradecanoylphorbol Acetate 133-171 GLI family zinc finger 2 Homo sapiens 92-97 3470005-2 1987 The protein, called Erythroid Differentiation Factor (EDF), was found in a 4 day culture of THP-1 cells performed in the presence of 4 beta-phorbol 12-myristate 13-acetate(PMA). Tetradecanoylphorbol Acetate 172-175 GLI family zinc finger 2 Homo sapiens 92-97 2867824-1 1986 Retinoic acid (RA) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced differentiation of a human monocytic leukemia cell line, THP-1. Tetradecanoylphorbol Acetate 23-60 GLI family zinc finger 2 Homo sapiens 132-137 2867824-1 1986 Retinoic acid (RA) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced differentiation of a human monocytic leukemia cell line, THP-1. Tetradecanoylphorbol Acetate 62-65 GLI family zinc finger 2 Homo sapiens 132-137 2867824-7 1986 A 15-min exposure to TPA was sufficient to induce differentiation and expression of tissue transglutaminase in THP-1 cells. Tetradecanoylphorbol Acetate 21-24 GLI family zinc finger 2 Homo sapiens 111-116 6949641-2 1982 In an original cell line, THP-1-O, cultured again from -80 degrees cryopreservation, more than 80% of the cells adhered to the glass substrate with marked morphological change within 3 hr of TPA treatment. Tetradecanoylphorbol Acetate 191-194 GLI family zinc finger 2 Homo sapiens 26-31 6949641-5 1982 On the other hand, in THP-1-R cells cultured continuously without cryopreservation for 26 months, approximately 80% of the cells adhered to the substrate 48 hr after TPA treatment. Tetradecanoylphorbol Acetate 166-169 GLI family zinc finger 2 Homo sapiens 22-27 6949641-6 1982 Round and ovoid shapes were kept in THP-1-R cells treated with TPA. Tetradecanoylphorbol Acetate 63-66 GLI family zinc finger 2 Homo sapiens 36-41 6949641-8 1982 Sixty to 70% of the TPA-treated THP-1-O and THP-1-R cells were able to phagocytize yeasts and immunoglobulin G-coated sheep erythrocytes. Tetradecanoylphorbol Acetate 20-23 GLI family zinc finger 2 Homo sapiens 32-37 6949641-12 1982 When exposed to latex beads and TPA, increased 14CO2 production from [1-14C]glucose in THP-1-O cells was observed. Tetradecanoylphorbol Acetate 32-35 GLI family zinc finger 2 Homo sapiens 87-92 32425545-8 2020 Results: Human Thp-1 monocytes were successfully polarized into M2-like TAMs using PMA, IL-6, and IL-4. Tetradecanoylphorbol Acetate 83-86 GLI family zinc finger 2 Homo sapiens 15-20 33074126-3 2021 In this study, our data showed that phorbol 12-myristate 13-acetate (PMA) treatment induced human leukemia monocytic cells (ThP-1) differentiation to M0 macrophages. Tetradecanoylphorbol Acetate 36-67 GLI family zinc finger 2 Homo sapiens 124-129 33074126-3 2021 In this study, our data showed that phorbol 12-myristate 13-acetate (PMA) treatment induced human leukemia monocytic cells (ThP-1) differentiation to M0 macrophages. Tetradecanoylphorbol Acetate 69-72 GLI family zinc finger 2 Homo sapiens 124-129 32819103-1 2020 Phorbol myristate acetate (PMA)-differentiated THP-1 cells are routinely used in lieu of primary macrophages to study macrophage polarization during host-pathogen interactions and disease progression. Tetradecanoylphorbol Acetate 0-25 GLI family zinc finger 2 Homo sapiens 47-52 32819103-1 2020 Phorbol myristate acetate (PMA)-differentiated THP-1 cells are routinely used in lieu of primary macrophages to study macrophage polarization during host-pathogen interactions and disease progression. Tetradecanoylphorbol Acetate 27-30 GLI family zinc finger 2 Homo sapiens 47-52 32819103-2 2020 The phenotypes of THP-1 macrophages are influenced by the level and duration of PMA stimulation and possibly also by the presence of adhesion factors. Tetradecanoylphorbol Acetate 80-83 GLI family zinc finger 2 Homo sapiens 18-23 32792604-6 2020 Human THP-1 monocytes were activated with phorbol-12-myristate-13-acetate (PMA) and differentiated into M1 macrophages with IFNgamma or M2 macrophages with IL4. Tetradecanoylphorbol Acetate 42-73 GLI family zinc finger 2 Homo sapiens 6-11 32792604-6 2020 Human THP-1 monocytes were activated with phorbol-12-myristate-13-acetate (PMA) and differentiated into M1 macrophages with IFNgamma or M2 macrophages with IL4. Tetradecanoylphorbol Acetate 75-78 GLI family zinc finger 2 Homo sapiens 6-11 33387144-5 2021 THP-1 monocytes were incubated with phorbol 12-myristate-13-acetate (PMA) to differentiate into macrophages, and then incubated with LPS and IS for 24 h. ELISA was used to detect the levels of TNFalpha, IL-6, IL-1beta in THP-1-derived macrophages. Tetradecanoylphorbol Acetate 36-67 GLI family zinc finger 2 Homo sapiens 0-5 33387144-5 2021 THP-1 monocytes were incubated with phorbol 12-myristate-13-acetate (PMA) to differentiate into macrophages, and then incubated with LPS and IS for 24 h. ELISA was used to detect the levels of TNFalpha, IL-6, IL-1beta in THP-1-derived macrophages. Tetradecanoylphorbol Acetate 69-72 GLI family zinc finger 2 Homo sapiens 0-5 32602900-7 2020 In cell line models, PD-L1 expression was found to be significantly enhanced in phorbol-12-myristate 13-acetate activated THP-1 human monocytes (macrophages) treated with LPS or incubated in conditioned media (CM) generated by non-small cell lung cancer (NSCLC) cells. Tetradecanoylphorbol Acetate 80-111 GLI family zinc finger 2 Homo sapiens 122-127 33187327-4 2020 The Exo were isolated from lipopolysaccharide (LPS)-stimulated phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages. Tetradecanoylphorbol Acetate 63-94 GLI family zinc finger 2 Homo sapiens 116-121 33187327-4 2020 The Exo were isolated from lipopolysaccharide (LPS)-stimulated phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages. Tetradecanoylphorbol Acetate 96-99 GLI family zinc finger 2 Homo sapiens 116-121 33084597-5 2020 In this study, human monocyte, THP-1 was induced to macrophages by using phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 73-104 GLI family zinc finger 2 Homo sapiens 31-36 33084597-5 2020 In this study, human monocyte, THP-1 was induced to macrophages by using phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 106-109 GLI family zinc finger 2 Homo sapiens 31-36 32441363-2 2020 METHODS: Inflammatory responses from RAW264.7 cells and THP-1 were stimulated by lipopolysaccharide (1 microg/ml), and monocyte-to-macrophage differentiation of THP-1 was induced by phorbol myristate acetate (50 ng/ml). Tetradecanoylphorbol Acetate 182-207 GLI family zinc finger 2 Homo sapiens 56-61 32441363-2 2020 METHODS: Inflammatory responses from RAW264.7 cells and THP-1 were stimulated by lipopolysaccharide (1 microg/ml), and monocyte-to-macrophage differentiation of THP-1 was induced by phorbol myristate acetate (50 ng/ml). Tetradecanoylphorbol Acetate 182-207 GLI family zinc finger 2 Homo sapiens 161-166 32441363-6 2020 In THP-1 cells, BR inhibited phorbol myristate acetate-induced monocyte-to-macrophage differentiation by suppressing cluster of differentiation molecule beta and CD36. Tetradecanoylphorbol Acetate 29-54 GLI family zinc finger 2 Homo sapiens 3-8 32673443-7 2020 We collected the conditioned medium from lipopolysaccharide-activated phorbol myristate acetate-induced THP1 (M1) cells to stimulate A549 and H1299 cells and observed that THP1-M1 upregulated SOD-2 by secreting TNF-alpha. Tetradecanoylphorbol Acetate 70-95 GLI family zinc finger 2 Homo sapiens 104-108 32673443-7 2020 We collected the conditioned medium from lipopolysaccharide-activated phorbol myristate acetate-induced THP1 (M1) cells to stimulate A549 and H1299 cells and observed that THP1-M1 upregulated SOD-2 by secreting TNF-alpha. Tetradecanoylphorbol Acetate 70-95 GLI family zinc finger 2 Homo sapiens 172-176 32719792-2 2020 Here we have employed Cap Analysis of Gene Expression (CAGE) to analyze a dense time course of transcriptional regulation in THP-1 cells treated with phorbol myristate acetate (PMA) over 96 h. PMA treatment greatly reduced the numbers of cells entering S phase and also blocked cells exiting G2/M. Tetradecanoylphorbol Acetate 150-175 GLI family zinc finger 2 Homo sapiens 125-130 32719792-2 2020 Here we have employed Cap Analysis of Gene Expression (CAGE) to analyze a dense time course of transcriptional regulation in THP-1 cells treated with phorbol myristate acetate (PMA) over 96 h. PMA treatment greatly reduced the numbers of cells entering S phase and also blocked cells exiting G2/M. Tetradecanoylphorbol Acetate 177-180 GLI family zinc finger 2 Homo sapiens 125-130 32719792-2 2020 Here we have employed Cap Analysis of Gene Expression (CAGE) to analyze a dense time course of transcriptional regulation in THP-1 cells treated with phorbol myristate acetate (PMA) over 96 h. PMA treatment greatly reduced the numbers of cells entering S phase and also blocked cells exiting G2/M. Tetradecanoylphorbol Acetate 193-196 GLI family zinc finger 2 Homo sapiens 125-130 30991038-4 2019 RIF treatment significantly induced MDR1 protein and mRNA levels in phorbol 12-myristate 13-acetate-stimulated THP1 macrophages (p < 0.001 and 0.01, respectively). Tetradecanoylphorbol Acetate 68-99 GLI family zinc finger 2 Homo sapiens 111-115 30927246-4 2020 THP-1 macrophages differentiated with phorbol 12-myristate 13-acetate (PMA) were incubated in vitro for 48 h with 1 muM or 10 muM sodium orthovanadate (Na3VO4). Tetradecanoylphorbol Acetate 38-69 GLI family zinc finger 2 Homo sapiens 0-5 30927246-4 2020 THP-1 macrophages differentiated with phorbol 12-myristate 13-acetate (PMA) were incubated in vitro for 48 h with 1 muM or 10 muM sodium orthovanadate (Na3VO4). Tetradecanoylphorbol Acetate 71-74 GLI family zinc finger 2 Homo sapiens 0-5 31423543-6 2019 For these purposes, human acute monocytic leukaemia cells (THP-1) were differentiated into macrophages with 12-O-tetradecanoylphorbol-13-acetate (TPA), followed by an incubation with PA or DHA. Tetradecanoylphorbol Acetate 108-144 GLI family zinc finger 2 Homo sapiens 59-64 31423252-10 2019 It was identified that treatment with interleukin (IL)-4, IL-13 and Phorbol-12-myristate-13-acetate successfully induced THP-1 to form TAMs. Tetradecanoylphorbol Acetate 68-99 GLI family zinc finger 2 Homo sapiens 121-126 29790117-3 2018 This hypothesis was tested in human acute monocytic leukemia cells (THP-1), which were differentiated into macrophages with 2-O-tetradecanoylphorbol-13-acetate (TPA) and further activated with LPS for 24 h. Monocytes, macrophages, and AcM were transfected with a negative control, or mimics for miR-155-3p and miR-let-7b-5p. Tetradecanoylphorbol Acetate 161-164 GLI family zinc finger 2 Homo sapiens 68-73 30320338-5 2018 Among them, Anatase-type TiO2 particles with a primary diameter of 50 nm (A50) were reported to induce interleukin (IL)-1beta production and secretion effectively in phorbol 12-myristate 13-acetate-treated human monocytic leukemia THP-1 cells (THP-1 macrophages). Tetradecanoylphorbol Acetate 166-197 GLI family zinc finger 2 Homo sapiens 231-236 30320338-5 2018 Among them, Anatase-type TiO2 particles with a primary diameter of 50 nm (A50) were reported to induce interleukin (IL)-1beta production and secretion effectively in phorbol 12-myristate 13-acetate-treated human monocytic leukemia THP-1 cells (THP-1 macrophages). Tetradecanoylphorbol Acetate 166-197 GLI family zinc finger 2 Homo sapiens 244-249 30081297-2 2018 In this study, we demonstrate that treatment with Calcimycin in PMA (Phorbol 12-myristate 13-acetate) differentiated THP-1 (dTHP-1) cells significantly induced interleukin (IL)-12 mRNA expression and its release. Tetradecanoylphorbol Acetate 64-67 GLI family zinc finger 2 Homo sapiens 117-122 30081297-2 2018 In this study, we demonstrate that treatment with Calcimycin in PMA (Phorbol 12-myristate 13-acetate) differentiated THP-1 (dTHP-1) cells significantly induced interleukin (IL)-12 mRNA expression and its release. Tetradecanoylphorbol Acetate 69-100 GLI family zinc finger 2 Homo sapiens 117-122 31142080-2 2019 Methods: THP-1 monocyte was incubated with PMA for 48 hours to induce the differentiation into macrophages. Tetradecanoylphorbol Acetate 43-46 GLI family zinc finger 2 Homo sapiens 9-14 30793846-11 2019 All O-2",3"-guanosine ketals were tested on their cytostatic/cytotoxic activity towards phorbol 12-myristate 13-acetate (PMA)-differentiated human THP-1 macrophages as well as against human astrocytoma/oligodendroglioma GOS-3 cells and against rat malignant neuroectodermal BT4Ca cells. Tetradecanoylphorbol Acetate 121-124 GLI family zinc finger 2 Homo sapiens 147-152 30218697-0 2019 Di-n-butyl phthalate modifies PMA-induced macrophage differentiation of THP-1 monocytes via PPARgamma. Tetradecanoylphorbol Acetate 30-33 GLI family zinc finger 2 Homo sapiens 72-77 30218697-1 2019 The present study examined the effects of di-n-butyl phthalate (DBP) on phorbol myristate acetate (PMA)-induced macrophage differentiation of THP-1 monocytes, determined by morphological classification and flow cytometry. Tetradecanoylphorbol Acetate 72-97 GLI family zinc finger 2 Homo sapiens 142-147 30218697-1 2019 The present study examined the effects of di-n-butyl phthalate (DBP) on phorbol myristate acetate (PMA)-induced macrophage differentiation of THP-1 monocytes, determined by morphological classification and flow cytometry. Tetradecanoylphorbol Acetate 99-102 GLI family zinc finger 2 Homo sapiens 142-147 30218697-10 2019 Overall, the results show that DBP modifies PMA-induced differentiation of THP-1 cells through interaction with PPARgamma. Tetradecanoylphorbol Acetate 44-47 GLI family zinc finger 2 Homo sapiens 75-80 30393145-6 2019 THP-1 cells were differentiated with phorbol-12-myristate-13-acetate (20 ng/ml, 48 h). Tetradecanoylphorbol Acetate 37-68 GLI family zinc finger 2 Homo sapiens 0-5 30372888-3 2018 First, we use phorbol-12-myristate-13-acetate (PMA), a phorbol ester, to induce THP-1 cells into macrophages as macrophages model. Tetradecanoylphorbol Acetate 14-45 GLI family zinc finger 2 Homo sapiens 80-85 30372888-3 2018 First, we use phorbol-12-myristate-13-acetate (PMA), a phorbol ester, to induce THP-1 cells into macrophages as macrophages model. Tetradecanoylphorbol Acetate 47-50 GLI family zinc finger 2 Homo sapiens 80-85 30626470-2 2018 Methods THP-1 macrophages were induced from THP-1 cells treated by 100 ng/mL phorbol ester (PMA), and then identified by morphological observation and DiI-oxLDL uptake assay. Tetradecanoylphorbol Acetate 92-95 GLI family zinc finger 2 Homo sapiens 8-13 30626470-2 2018 Methods THP-1 macrophages were induced from THP-1 cells treated by 100 ng/mL phorbol ester (PMA), and then identified by morphological observation and DiI-oxLDL uptake assay. Tetradecanoylphorbol Acetate 92-95 GLI family zinc finger 2 Homo sapiens 44-49 30242126-7 2018 In contrast, elevated basal expression of membrane-bound CD14 in phorbol 12-myristate 13-acetate (PMA)-THP-1 cells, primary monocytes, and primary macrophages may promote CD14-mediated endocytosis and be responsible for the preservation of an endotoxin-tolerized state in the presence of IL-27. Tetradecanoylphorbol Acetate 65-96 GLI family zinc finger 2 Homo sapiens 103-108 30465338-2 2018 METHODS: THP-1 cells (a human monocytic cell line derived from an acute monocytic leukemia patient) were induced to differentiate THP-1 macrophages by phorbol-12-myristate-13-acetate and were injected with 0 (blank control), 0.5, or 1.0 mug mL-1 Pg-LPS. Tetradecanoylphorbol Acetate 151-182 GLI family zinc finger 2 Homo sapiens 9-14 29966967-3 2018 THP-1 monocytes were differentiated to macrophages using phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 57-88 GLI family zinc finger 2 Homo sapiens 0-5 30158075-6 2018 Here we demonstrate that when the human macrophage cell line THP-1 are cultured in FACS tubes with phorbol myristate acetate added, they undergo differentiation into macrophages, assessed morphologically and by autofluorescence expression, in a similar manner to those cultured in tissue culture dishes. Tetradecanoylphorbol Acetate 99-124 GLI family zinc finger 2 Homo sapiens 61-66 30157903-3 2018 METHODS: Human THP-1 monocytes were induced to differentiate into M2 macrophages through treatments with IL-4, IL-13, and phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 122-147 GLI family zinc finger 2 Homo sapiens 15-20 29704820-5 2018 METHODS: We used human lung fibroblasts and THP-1 macrophages differentiated from THP-1 cells using phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 100-131 GLI family zinc finger 2 Homo sapiens 82-87 29798705-6 2018 In this work, the ability of L. fermentum UCO-979C to modulate immune response in AGS cells and PMA phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 (human monocytic leukaemia) macrophages in response to H. pylori infection was evaluated. Tetradecanoylphorbol Acetate 100-131 GLI family zinc finger 2 Homo sapiens 153-158 29798705-6 2018 In this work, the ability of L. fermentum UCO-979C to modulate immune response in AGS cells and PMA phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 (human monocytic leukaemia) macrophages in response to H. pylori infection was evaluated. Tetradecanoylphorbol Acetate 96-99 GLI family zinc finger 2 Homo sapiens 153-158 30157903-3 2018 METHODS: Human THP-1 monocytes were induced to differentiate into M2 macrophages through treatments with IL-4, IL-13, and phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 149-152 GLI family zinc finger 2 Homo sapiens 15-20 29970564-3 2018 MATERIALS AND METHODS: THP-1 macrophages were induced by 12-O-tetradecanoyl-13-acetate (TPA). Tetradecanoylphorbol Acetate 88-91 GLI family zinc finger 2 Homo sapiens 23-28 29398679-5 2018 METHODS: THP-1 monocytes, a human leukemic cell line, were stimulated with 50 ng/mL of phorbol-12-myristate-13-acetate (PMA) 1 h after pretreatment with 10 muM azelnidipine or dimethyl sulfoxide (DMSO), and harvested. Tetradecanoylphorbol Acetate 87-118 GLI family zinc finger 2 Homo sapiens 9-14 29398679-5 2018 METHODS: THP-1 monocytes, a human leukemic cell line, were stimulated with 50 ng/mL of phorbol-12-myristate-13-acetate (PMA) 1 h after pretreatment with 10 muM azelnidipine or dimethyl sulfoxide (DMSO), and harvested. Tetradecanoylphorbol Acetate 120-123 GLI family zinc finger 2 Homo sapiens 9-14 29683455-9 2018 By adimistration of 10 ng/mL phorbol 12-myristate 13-acetate (PMA) for 72 h, THP-1 cells differentiated into macrophages to form inflammatory foci in GTE (iGTE) (IGTE also can be stumilated with 2 microg/mL of lipopolysaccharides (LPS) for 48 h to initiate inflammation). Tetradecanoylphorbol Acetate 29-60 GLI family zinc finger 2 Homo sapiens 77-82 29656208-3 2018 M0 macrophages derived from the phorbol-12-myristate-13-acetate-induced human acute monocytic leukemia cell line THP-1 were cultured with T. pallidum. Tetradecanoylphorbol Acetate 32-63 GLI family zinc finger 2 Homo sapiens 113-118 29477140-3 2018 We observed that, upon phorbol 12-myristate 13-acetate (PMA) treatment, THP-1 cells differentiated into monocytes by down-regulating Aurora kinase A (AURKA), resulting in a reduction in H3S10 phosphorylation. Tetradecanoylphorbol Acetate 23-54 GLI family zinc finger 2 Homo sapiens 72-77 29477140-3 2018 We observed that, upon phorbol 12-myristate 13-acetate (PMA) treatment, THP-1 cells differentiated into monocytes by down-regulating Aurora kinase A (AURKA), resulting in a reduction in H3S10 phosphorylation. Tetradecanoylphorbol Acetate 56-59 GLI family zinc finger 2 Homo sapiens 72-77 29477140-6 2018 Furthermore, we found that treatment with the KDM6B inhibitor GSK-J4 perturbed the PMA-mediated differentiation of THP-1 cells. Tetradecanoylphorbol Acetate 83-86 GLI family zinc finger 2 Homo sapiens 115-120 29683455-9 2018 By adimistration of 10 ng/mL phorbol 12-myristate 13-acetate (PMA) for 72 h, THP-1 cells differentiated into macrophages to form inflammatory foci in GTE (iGTE) (IGTE also can be stumilated with 2 microg/mL of lipopolysaccharides (LPS) for 48 h to initiate inflammation). Tetradecanoylphorbol Acetate 62-65 GLI family zinc finger 2 Homo sapiens 77-82 29313085-8 2018 The analysis of total RNA samples in GEO datasets from K562, HL-60, THP-1 and U937 cell lines, untreated or treated with TPA in replicated experiments confirmed our earlier results. Tetradecanoylphorbol Acetate 121-124 GLI family zinc finger 2 Homo sapiens 68-73 29933732-0 2018 [Investigation of cytokine and midkine responses of human THP-1 leukemia cells induced by phorbol-12-Myristate-13-Acetate (PMA) at different concentrations and times]. Tetradecanoylphorbol Acetate 90-121 GLI family zinc finger 2 Homo sapiens 58-63 29933732-0 2018 [Investigation of cytokine and midkine responses of human THP-1 leukemia cells induced by phorbol-12-Myristate-13-Acetate (PMA) at different concentrations and times]. Tetradecanoylphorbol Acetate 123-126 GLI family zinc finger 2 Homo sapiens 58-63 29039753-0 2017 PMA-Induced THP-1 Macrophage Differentiation is Not Impaired by Citrate-Coated Platinum Nanoparticles. Tetradecanoylphorbol Acetate 0-3 GLI family zinc finger 2 Homo sapiens 12-17 29538403-0 2018 The phorbol 12-myristate-13-acetate differentiation protocol is critical to the interaction of THP-1 macrophages with Salmonella Typhimurium. Tetradecanoylphorbol Acetate 4-35 GLI family zinc finger 2 Homo sapiens 95-100 29538403-1 2018 THP-1 cells differentiated with phorbol 12-myristate 13-acetate (PMA) are widely used as a model for function and biology of human macrophages. Tetradecanoylphorbol Acetate 32-63 GLI family zinc finger 2 Homo sapiens 0-5 29407889-8 2018 Double-radiolabeled HDL (125I-TC-/[3H] CEt-HDL) was utilized to measure the effects of miR-24 on HDL and CE binding and SLU in HepG2 and PMA-treated THP-1 cells. Tetradecanoylphorbol Acetate 137-140 GLI family zinc finger 2 Homo sapiens 149-154 28922584-3 2018 The pro-inflammatory properties of mold particles were examined in human bronchial epithelial cells (BEAS-2B) and THP-1 monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1. Tetradecanoylphorbol Acetate 167-170 GLI family zinc finger 2 Homo sapiens 187-192 28830685-5 2017 PMA-treated THP-1 cells were co-cultured with human A549 cells culture supernatant. Tetradecanoylphorbol Acetate 0-3 GLI family zinc finger 2 Homo sapiens 12-17 28986583-3 2017 Here we report the pro-inflammatory effect of ImI, a well characterized conotoxin that inhibits alpha7 nAChRs, on differentiated THP-1 pre-monocyte macrophages (MDM) obtained by phorbol 12-myristate 13 acetate (PMA) treatment. Tetradecanoylphorbol Acetate 178-209 GLI family zinc finger 2 Homo sapiens 129-134 28986583-3 2017 Here we report the pro-inflammatory effect of ImI, a well characterized conotoxin that inhibits alpha7 nAChRs, on differentiated THP-1 pre-monocyte macrophages (MDM) obtained by phorbol 12-myristate 13 acetate (PMA) treatment. Tetradecanoylphorbol Acetate 211-214 GLI family zinc finger 2 Homo sapiens 129-134 29538403-1 2018 THP-1 cells differentiated with phorbol 12-myristate 13-acetate (PMA) are widely used as a model for function and biology of human macrophages. Tetradecanoylphorbol Acetate 65-68 GLI family zinc finger 2 Homo sapiens 0-5 28600650-3 2018 The differentiation of THP-1 monocytes into macrophages was achieved by administration of phorbol myristate acetate. Tetradecanoylphorbol Acetate 90-115 GLI family zinc finger 2 Homo sapiens 23-28 29520230-3 2018 In view of their distinct developmental origins and phenotypic attributes, we set out to assess the extent to which human monocyte-derived macrophages (MDMs) and phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells were overlapping across a variety of responses to activating stimuli. Tetradecanoylphorbol Acetate 162-193 GLI family zinc finger 2 Homo sapiens 215-220 29520230-3 2018 In view of their distinct developmental origins and phenotypic attributes, we set out to assess the extent to which human monocyte-derived macrophages (MDMs) and phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells were overlapping across a variety of responses to activating stimuli. Tetradecanoylphorbol Acetate 195-198 GLI family zinc finger 2 Homo sapiens 215-220 29385060-2 2018 Various forms of OPN were identified in human monocytic THP-1 cells stimulated by phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 82-113 GLI family zinc finger 2 Homo sapiens 56-61 29385060-2 2018 Various forms of OPN were identified in human monocytic THP-1 cells stimulated by phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 115-118 GLI family zinc finger 2 Homo sapiens 56-61 28983613-6 2017 Suspended THP-1 cells were stimulated for 2 days with 5 or 100 ng/ml phorbol-12 myristate-13 acetate (PMA) in order to induce the cells to differentiate into adherent macrophages. Tetradecanoylphorbol Acetate 69-100 GLI family zinc finger 2 Homo sapiens 10-15 28983613-6 2017 Suspended THP-1 cells were stimulated for 2 days with 5 or 100 ng/ml phorbol-12 myristate-13 acetate (PMA) in order to induce the cells to differentiate into adherent macrophages. Tetradecanoylphorbol Acetate 102-105 GLI family zinc finger 2 Homo sapiens 10-15 28765923-0 2017 Bombyx mori hemocyte extract has anti-inflammatory effects on human phorbol myristate acetate-differentiated THP-1 cells via TLR4-mediated suppression of the NF-kappaB signaling pathway. Tetradecanoylphorbol Acetate 68-93 GLI family zinc finger 2 Homo sapiens 109-114 28260067-5 2017 These results suggested that Delta19-RhoGDIbeta has an apoptosis-independent role in the PMA-induced differentiation of THP-1 cells to macrophages. Tetradecanoylphorbol Acetate 89-92 GLI family zinc finger 2 Homo sapiens 120-125 28440421-4 2017 THP-1 cells were exposed to 100 nM phorbol myristate acetate (PMA) for 24 h, and then to oxydized low-density lipoprotein (ox-LDL; 50 mg/ml) to induce foam cell formation. Tetradecanoylphorbol Acetate 35-60 GLI family zinc finger 2 Homo sapiens 0-5 28440421-4 2017 THP-1 cells were exposed to 100 nM phorbol myristate acetate (PMA) for 24 h, and then to oxydized low-density lipoprotein (ox-LDL; 50 mg/ml) to induce foam cell formation. Tetradecanoylphorbol Acetate 62-65 GLI family zinc finger 2 Homo sapiens 0-5 28659229-2 2017 showed that homeopathic preparations of Arnica montana L. acted directly on gene expression of Tamm-Horsfall protein-1 (THP-1) monocyte/macrophage cell lines activated with phorbol12-myristate13-acetate and interleukin-4 (IL-4). Tetradecanoylphorbol Acetate 173-202 GLI family zinc finger 2 Homo sapiens 120-125 30650487-2 2017 Methods Human acute leukemia mononuclear strain THP-1 was induced to become TAMs using Phorbol-12-myristate-13-acetate (PMA) combined IL-4 and IL- 13. Tetradecanoylphorbol Acetate 87-118 GLI family zinc finger 2 Homo sapiens 48-53 28166796-5 2017 Chemically-induced Gaucher macrophages were developed by differentiateing THP-1 monocytes to macrophages by treatment with phorbol 12-myristate 13-acetate (PMA) and then inhibiting intracellular GCase with conduritol B-epoxide (CBE), a specific irreversible inhibitor of GCase activity, and supplementing the medium with exogenous GlcCer. Tetradecanoylphorbol Acetate 123-154 GLI family zinc finger 2 Homo sapiens 74-79 28166796-5 2017 Chemically-induced Gaucher macrophages were developed by differentiateing THP-1 monocytes to macrophages by treatment with phorbol 12-myristate 13-acetate (PMA) and then inhibiting intracellular GCase with conduritol B-epoxide (CBE), a specific irreversible inhibitor of GCase activity, and supplementing the medium with exogenous GlcCer. Tetradecanoylphorbol Acetate 156-159 GLI family zinc finger 2 Homo sapiens 74-79 28119118-5 2017 We observed that stimulator of interferon genes (STING) limited HTLV-1 protein expression and was critical to HTLV-1 reverse transcription intermediate (RTI) ssDNA90 triggered interferon (IFN)-beta production in phorbol12-myristate13-acetate (PMA)-differentiated THP1 (PMA-THP1) cells. Tetradecanoylphorbol Acetate 212-241 GLI family zinc finger 2 Homo sapiens 263-267 28119118-5 2017 We observed that stimulator of interferon genes (STING) limited HTLV-1 protein expression and was critical to HTLV-1 reverse transcription intermediate (RTI) ssDNA90 triggered interferon (IFN)-beta production in phorbol12-myristate13-acetate (PMA)-differentiated THP1 (PMA-THP1) cells. Tetradecanoylphorbol Acetate 212-241 GLI family zinc finger 2 Homo sapiens 269-277 30650487-2 2017 Methods Human acute leukemia mononuclear strain THP-1 was induced to become TAMs using Phorbol-12-myristate-13-acetate (PMA) combined IL-4 and IL- 13. Tetradecanoylphorbol Acetate 120-123 GLI family zinc finger 2 Homo sapiens 48-53 27994457-5 2016 PMA treatment also significantly increased the traction of THP1 cells on bovine serum albumin proteins, although the effect on K562 cells was insignificant. Tetradecanoylphorbol Acetate 0-3 GLI family zinc finger 2 Homo sapiens 59-63 28160867-3 2017 PURPOSE: This study focused on assessing the anti-inflammatory effects of fargesin on phorbal ester (PMA)-stimulated THP-1 human monocytes, and the molecular mechanisms underlying them. Tetradecanoylphorbol Acetate 101-104 GLI family zinc finger 2 Homo sapiens 117-122 27816791-7 2017 METHODS: M1- and M2-like Mphis were generated in vitro from the THP-1 monocyte cell line by differentiation with PMA and Vitamin D3, respectively. Tetradecanoylphorbol Acetate 113-116 GLI family zinc finger 2 Homo sapiens 64-69 27910925-5 2016 First, we found that TM was increased when THP-1 cells were treated with phorbol-12-myristate-13-acetate (PMA). Tetradecanoylphorbol Acetate 73-104 GLI family zinc finger 2 Homo sapiens 43-48 27910925-5 2016 First, we found that TM was increased when THP-1 cells were treated with phorbol-12-myristate-13-acetate (PMA). Tetradecanoylphorbol Acetate 106-109 GLI family zinc finger 2 Homo sapiens 43-48 29045950-3 2017 METHODS: Human THP-1 cells were fully differentiated into foam cells by the pre-treatment with phorbol-12-myristate-13-acetate (PMA) and oxidized density lipoproteins (ox-LDL). Tetradecanoylphorbol Acetate 95-126 GLI family zinc finger 2 Homo sapiens 15-20 29045950-3 2017 METHODS: Human THP-1 cells were fully differentiated into foam cells by the pre-treatment with phorbol-12-myristate-13-acetate (PMA) and oxidized density lipoproteins (ox-LDL). Tetradecanoylphorbol Acetate 128-131 GLI family zinc finger 2 Homo sapiens 15-20 27467817-5 2016 METHODS AND RESULTS: Phorbol myristate acetate (PMA) differentiated THP-1 macrophages were stimulated with oxidized low density lipoprotein and subsequent analysis of this conditioned media (oxLDL CM) revealed a strong release of TNF-alpha. Tetradecanoylphorbol Acetate 21-46 GLI family zinc finger 2 Homo sapiens 68-73 28105139-4 2016 Phorbol 12-myristate 13-acetate-stimulated THP-1 cells were treated with oxidized low-density lipoprotein and (3H)-cholesterol for 24 h, and the effects of baicalin on cholesterol efflux were evaluated in the presence of apolipoprotein A-1 (ApoA-1), or high-density lipoprotein subfraction 2 (HDL2) or subfraction 3 (HDL3). Tetradecanoylphorbol Acetate 0-31 GLI family zinc finger 2 Homo sapiens 43-48 27240473-8 2016 For the tolerance test, THP-1 cells transfected with miRNA-128 mimic were treated with phorbol 12-myristate 13-acetate (PMA) or paraformaldehyde (PFA)-fixed Escherichia coli. Tetradecanoylphorbol Acetate 120-123 GLI family zinc finger 2 Homo sapiens 24-29 27240473-13 2016 In THP-1 cells transfected with miRNA-128 mimic, TNF-alpha production was lower, and phosphorylation of p38 was inhibited when challenged with PMA or PFA-fixed E. coli. Tetradecanoylphorbol Acetate 143-146 GLI family zinc finger 2 Homo sapiens 3-8 27307103-8 2016 However, the phorbol 12-myristate 13-acetate (PMA)-induced differentiation of U937 and THP-1 cell lines induces a significant tumor necrosis factor-alpha production in resting macrophages. Tetradecanoylphorbol Acetate 13-44 GLI family zinc finger 2 Homo sapiens 87-92 27307103-8 2016 However, the phorbol 12-myristate 13-acetate (PMA)-induced differentiation of U937 and THP-1 cell lines induces a significant tumor necrosis factor-alpha production in resting macrophages. Tetradecanoylphorbol Acetate 46-49 GLI family zinc finger 2 Homo sapiens 87-92 27467817-5 2016 METHODS AND RESULTS: Phorbol myristate acetate (PMA) differentiated THP-1 macrophages were stimulated with oxidized low density lipoprotein and subsequent analysis of this conditioned media (oxLDL CM) revealed a strong release of TNF-alpha. Tetradecanoylphorbol Acetate 48-51 GLI family zinc finger 2 Homo sapiens 68-73 27365551-3 2016 METHODS: THP-1 cells (a human monocytic cell line) were cultured and differentiated to macrophages by phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 102-133 GLI family zinc finger 2 Homo sapiens 9-14 27176480-3 2016 In this study, phorbol myristate acetate (PMA) was used to induce the differentiation of THP-1 monocytes to macrophages. Tetradecanoylphorbol Acetate 15-40 GLI family zinc finger 2 Homo sapiens 89-94 27176480-3 2016 In this study, phorbol myristate acetate (PMA) was used to induce the differentiation of THP-1 monocytes to macrophages. Tetradecanoylphorbol Acetate 42-45 GLI family zinc finger 2 Homo sapiens 89-94 26826276-0 2016 The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus. Tetradecanoylphorbol Acetate 14-45 GLI family zinc finger 2 Homo sapiens 98-103 27452759-3 2016 Phorbol 12-myristate 13-acetate(PMA) and macrophage colony stimulating factor (M-CSF) were used to make THP-1 monocytes differentiate into TAMs. Tetradecanoylphorbol Acetate 0-31 GLI family zinc finger 2 Homo sapiens 104-109 27175590-4 2016 In this study, H68 fibroblasts, THP-1 and phorbol-12-myristate-13-acetate (PMA)-treated THP-1 (PMA-THP-1) cells were incubated with conditioned media of control (control-CM) and 14-3-3sigma-overepxressing cells (14-3-3sigma-CM), followed by co-culture with HCC cells. Tetradecanoylphorbol Acetate 42-73 GLI family zinc finger 2 Homo sapiens 88-93 27175590-4 2016 In this study, H68 fibroblasts, THP-1 and phorbol-12-myristate-13-acetate (PMA)-treated THP-1 (PMA-THP-1) cells were incubated with conditioned media of control (control-CM) and 14-3-3sigma-overepxressing cells (14-3-3sigma-CM), followed by co-culture with HCC cells. Tetradecanoylphorbol Acetate 42-73 GLI family zinc finger 2 Homo sapiens 95-104 27175590-4 2016 In this study, H68 fibroblasts, THP-1 and phorbol-12-myristate-13-acetate (PMA)-treated THP-1 (PMA-THP-1) cells were incubated with conditioned media of control (control-CM) and 14-3-3sigma-overepxressing cells (14-3-3sigma-CM), followed by co-culture with HCC cells. Tetradecanoylphorbol Acetate 75-78 GLI family zinc finger 2 Homo sapiens 88-93 27175590-4 2016 In this study, H68 fibroblasts, THP-1 and phorbol-12-myristate-13-acetate (PMA)-treated THP-1 (PMA-THP-1) cells were incubated with conditioned media of control (control-CM) and 14-3-3sigma-overepxressing cells (14-3-3sigma-CM), followed by co-culture with HCC cells. Tetradecanoylphorbol Acetate 75-78 GLI family zinc finger 2 Homo sapiens 95-104 27376806-4 2016 Phorbol12-myristate13-acetate (PMA) was used to induce human acute mononuclear leukemia cells THP-1 to differentiate into macrophages. Tetradecanoylphorbol Acetate 0-29 GLI family zinc finger 2 Homo sapiens 94-99 27376806-4 2016 Phorbol12-myristate13-acetate (PMA) was used to induce human acute mononuclear leukemia cells THP-1 to differentiate into macrophages. Tetradecanoylphorbol Acetate 31-34 GLI family zinc finger 2 Homo sapiens 94-99 26826276-2 2016 This is because, following differentiation using phorbol 12-myristate 13-acetate (PMA), THP-1 cells acquire a macrophage-like phenotype, which mimics, in many respects, primary human macrophages. Tetradecanoylphorbol Acetate 49-80 GLI family zinc finger 2 Homo sapiens 88-93 26826276-2 2016 This is because, following differentiation using phorbol 12-myristate 13-acetate (PMA), THP-1 cells acquire a macrophage-like phenotype, which mimics, in many respects, primary human macrophages. Tetradecanoylphorbol Acetate 82-85 GLI family zinc finger 2 Homo sapiens 88-93 26826276-8 2016 These data indicate that exposure of monocytic THP-1 cells to 25 nM PMA over 48 h, followed by a recovery period of 24h in culture in the absence of PMA, was the optimal protocol for the differentiation of THP-1 cells. Tetradecanoylphorbol Acetate 68-71 GLI family zinc finger 2 Homo sapiens 47-52 26826276-8 2016 These data indicate that exposure of monocytic THP-1 cells to 25 nM PMA over 48 h, followed by a recovery period of 24h in culture in the absence of PMA, was the optimal protocol for the differentiation of THP-1 cells. Tetradecanoylphorbol Acetate 68-71 GLI family zinc finger 2 Homo sapiens 206-211 26779131-10 2015 Co-incubation with a murine macrophage cell line J774a.1 or PMA-induced human monocytic cell line THP-1 demonstrated that mmar_2318 or mmar_2319 deletion mutant could grow in macrophages, and their initial entry rate was not affected in J774a.1 but significantly increased in THP-1. Tetradecanoylphorbol Acetate 60-63 GLI family zinc finger 2 Homo sapiens 98-103 26779131-10 2015 Co-incubation with a murine macrophage cell line J774a.1 or PMA-induced human monocytic cell line THP-1 demonstrated that mmar_2318 or mmar_2319 deletion mutant could grow in macrophages, and their initial entry rate was not affected in J774a.1 but significantly increased in THP-1. Tetradecanoylphorbol Acetate 60-63 GLI family zinc finger 2 Homo sapiens 276-281 27889764-5 2016 METHODS: We primed THP-1 cells with phorbol-12-myristate-13-acetate (PMA) for differentiation, then exposed cells to HUA and detected the production of reactive oxygen species (ROS) and analyzed the level of phospho-AMPKalpha. Tetradecanoylphorbol Acetate 36-67 GLI family zinc finger 2 Homo sapiens 19-24 27889764-5 2016 METHODS: We primed THP-1 cells with phorbol-12-myristate-13-acetate (PMA) for differentiation, then exposed cells to HUA and detected the production of reactive oxygen species (ROS) and analyzed the level of phospho-AMPKalpha. Tetradecanoylphorbol Acetate 69-72 GLI family zinc finger 2 Homo sapiens 19-24 25109682-5 2015 The treatment of THP-1 monocytes using phorbol 12-myristate 13-acetate (PMA) was shown to initiate inflammatory responses. Tetradecanoylphorbol Acetate 39-70 GLI family zinc finger 2 Homo sapiens 17-22 26927374-2 2016 METHODS: THP-1 cells were induced to differentiate into macrophages by 100 ng/mL phorbol 12-myristate 13-acetate (PMA) for 48 hours, and then the macrophages were further induced to generate foam cells by 50 mug/mL oxidized low-density lipoprotein (ox-LDL) and 1 mug/mL LPS. Tetradecanoylphorbol Acetate 81-112 GLI family zinc finger 2 Homo sapiens 9-14 26927374-2 2016 METHODS: THP-1 cells were induced to differentiate into macrophages by 100 ng/mL phorbol 12-myristate 13-acetate (PMA) for 48 hours, and then the macrophages were further induced to generate foam cells by 50 mug/mL oxidized low-density lipoprotein (ox-LDL) and 1 mug/mL LPS. Tetradecanoylphorbol Acetate 114-117 GLI family zinc finger 2 Homo sapiens 9-14 26582014-1 2015 Previous analyses have reported that the human monocytic cell line THP1 can be differentiated into cells with macrophage-like characteristics by phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 145-176 GLI family zinc finger 2 Homo sapiens 67-71 26582014-1 2015 Previous analyses have reported that the human monocytic cell line THP1 can be differentiated into cells with macrophage-like characteristics by phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 178-181 GLI family zinc finger 2 Homo sapiens 67-71 26253167-5 2015 METHODS: We set up a model of macrophage polarization, starting from THP-1 monocytes differentiated into macrophages using PMA (Phorbol 12-myristate 13-acetate). Tetradecanoylphorbol Acetate 128-159 GLI family zinc finger 2 Homo sapiens 69-74 26372376-7 2015 Secondly, autophagy is activated during PMA-induced THP-1 monocyte differentiation, and the autophagy inhibitor chloroquine (CQ) can inhibit this process. Tetradecanoylphorbol Acetate 40-43 GLI family zinc finger 2 Homo sapiens 52-57 26157065-2 2015 To this end, changes in the inflammatory profiles of lipopolysacchride (LPS)-stimulated phrobol 12-myristate 13-acetate(PMA)-differented THP-1 macrophages were evaluated following Chi IVa treatment. Tetradecanoylphorbol Acetate 120-123 GLI family zinc finger 2 Homo sapiens 137-142 25109682-5 2015 The treatment of THP-1 monocytes using phorbol 12-myristate 13-acetate (PMA) was shown to initiate inflammatory responses. Tetradecanoylphorbol Acetate 72-75 GLI family zinc finger 2 Homo sapiens 17-22 25411080-5 2015 THP-1 monocytic cells were used in this study to elucidate the influence of zoledronate and denosumab on phorbol-12-myrisate-13-acetate (PMA)-induced macrophage differentiation and function in real-time. Tetradecanoylphorbol Acetate 137-140 GLI family zinc finger 2 Homo sapiens 0-5 25834143-2 2015 Phorbol-12-myristate-13-acetate (PMA)-differentiated human acute monocytic leukemia cell line THP-1 was infected with H. pylori. Tetradecanoylphorbol Acetate 0-31 GLI family zinc finger 2 Homo sapiens 94-99 25834143-2 2015 Phorbol-12-myristate-13-acetate (PMA)-differentiated human acute monocytic leukemia cell line THP-1 was infected with H. pylori. Tetradecanoylphorbol Acetate 33-36 GLI family zinc finger 2 Homo sapiens 94-99 25042796-5 2014 Human monocytic cell line THP-1 cells stimulated with phorbol-12-myristate-13-acetate (PMA) differentiated to macrophages with M2-like phenotypes. Tetradecanoylphorbol Acetate 54-85 GLI family zinc finger 2 Homo sapiens 26-31 25461800-4 2015 The transcription and expression of the chpI, chpK, mazE, and mazF genes of Leptospira interrogans strain Lai were significantly increased during infection of phorbol 12-myristate 13-acetate-induced human THP-1 macrophages. Tetradecanoylphorbol Acetate 159-190 GLI family zinc finger 2 Homo sapiens 205-210 25333975-3 2014 We investigated the underlying mechanism of EP3 expression in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages with oxidized low-density lipoprotein (oxLDL) treatment. Tetradecanoylphorbol Acetate 62-93 GLI family zinc finger 2 Homo sapiens 115-120 25333975-3 2014 We investigated the underlying mechanism of EP3 expression in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages with oxidized low-density lipoprotein (oxLDL) treatment. Tetradecanoylphorbol Acetate 95-98 GLI family zinc finger 2 Homo sapiens 115-120 25726525-5 2015 Using previously established cell lines that stably express IL-32theta and IL-32beta and cell lines transiently expressing IL-32theta, we observed that expression of IL-32theta inhibited phorbol 12-myristate 13-acetate (PMA)-induced monocytic differentiation in both THP-1 and HL-60 cells. Tetradecanoylphorbol Acetate 187-218 GLI family zinc finger 2 Homo sapiens 267-272 25655563-3 2015 Computer simulations based on a transcriptional regulatory model deduced from the system-wide, ladder-like transcription factor cluster structure reproduced expression pattern transitions when human THP-1 myelomonocytic leukaemia cells cease proliferation and differentiate under phorbol myristate acetate stimulation. Tetradecanoylphorbol Acetate 280-305 GLI family zinc finger 2 Homo sapiens 199-204 25638774-3 2015 THP-1 cells were activated using TPA into macrophage-like cells and infected with M.abs for different time points. Tetradecanoylphorbol Acetate 33-36 GLI family zinc finger 2 Homo sapiens 0-5 25042796-5 2014 Human monocytic cell line THP-1 cells stimulated with phorbol-12-myristate-13-acetate (PMA) differentiated to macrophages with M2-like phenotypes. Tetradecanoylphorbol Acetate 87-90 GLI family zinc finger 2 Homo sapiens 26-31 24584901-4 2014 For this purpose, THP-1 cells were treated with 100 nM phorbol 12-myristate 13-acetate (PMA) to induce their differentiation into macrophages. Tetradecanoylphorbol Acetate 55-86 GLI family zinc finger 2 Homo sapiens 18-23 25202359-5 2014 TGFbeta1-exposed PCa cells were also co-cultured with phorbol 12-myristate 13-acetate (PMA)-treated THP-1 macrophages as a model of the tumor microenvironment. Tetradecanoylphorbol Acetate 54-85 GLI family zinc finger 2 Homo sapiens 100-105 25202359-5 2014 TGFbeta1-exposed PCa cells were also co-cultured with phorbol 12-myristate 13-acetate (PMA)-treated THP-1 macrophages as a model of the tumor microenvironment. Tetradecanoylphorbol Acetate 87-90 GLI family zinc finger 2 Homo sapiens 100-105 25200149-2 2014 METHODS: The macrophage model was established through incubating the human monocyte line (THP-1 cells) with phorbol-12-myristate 13-acetate (PMA) (10 ng/mL) for 48 hours. Tetradecanoylphorbol Acetate 108-139 GLI family zinc finger 2 Homo sapiens 90-95 25200149-2 2014 METHODS: The macrophage model was established through incubating the human monocyte line (THP-1 cells) with phorbol-12-myristate 13-acetate (PMA) (10 ng/mL) for 48 hours. Tetradecanoylphorbol Acetate 141-144 GLI family zinc finger 2 Homo sapiens 90-95 25158571-4 2014 To explore the importance of differentiation the monocytic cell line THP-1 was pre-treated with PMA and IFNy. Tetradecanoylphorbol Acetate 96-99 GLI family zinc finger 2 Homo sapiens 69-74 23564320-11 2014 We have found that, H3-Thr45 phosphorylation correlates to S6K activation in response to mitogens and TPA-induced cell differentiation of leukaemic cell lines U937, HL60 and THP1. Tetradecanoylphorbol Acetate 102-105 GLI family zinc finger 2 Homo sapiens 174-178 24699135-5 2014 LR11 was not expressed in THP-1 monocytes, but it was expressed and released in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 macrophages (PMA/THP-1). Tetradecanoylphorbol Acetate 80-111 GLI family zinc finger 2 Homo sapiens 126-131 24699135-5 2014 LR11 was not expressed in THP-1 monocytes, but it was expressed and released in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 macrophages (PMA/THP-1). Tetradecanoylphorbol Acetate 80-111 GLI family zinc finger 2 Homo sapiens 126-131 24699135-5 2014 LR11 was not expressed in THP-1 monocytes, but it was expressed and released in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 macrophages (PMA/THP-1). Tetradecanoylphorbol Acetate 113-116 GLI family zinc finger 2 Homo sapiens 126-131 24699135-5 2014 LR11 was not expressed in THP-1 monocytes, but it was expressed and released in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 macrophages (PMA/THP-1). Tetradecanoylphorbol Acetate 113-116 GLI family zinc finger 2 Homo sapiens 126-131 24699135-9 2014 Likewise, the PMA-stimulated release of sLR11 increased in THP-1 cells transfected with CD9-targeted shRNAs, which was negated by treatment with the metalloproteinase inhibitor GM6001. Tetradecanoylphorbol Acetate 14-17 GLI family zinc finger 2 Homo sapiens 59-64 23913269-5 2014 The aim of this study was to characterize the interactions between TG2 and sPLA2 in LPS-stimulated THP-1 cells, which were treated with TPA to induce early differentiated macrophage-type model. Tetradecanoylphorbol Acetate 136-139 GLI family zinc finger 2 Homo sapiens 99-104 24584901-4 2014 For this purpose, THP-1 cells were treated with 100 nM phorbol 12-myristate 13-acetate (PMA) to induce their differentiation into macrophages. Tetradecanoylphorbol Acetate 88-91 GLI family zinc finger 2 Homo sapiens 18-23 24391778-4 2013 We first examined whether MBL modulated heat-killed (HK) C. albicans-induced cellular responses in phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 macrophages. Tetradecanoylphorbol Acetate 99-130 GLI family zinc finger 2 Homo sapiens 153-158 24391778-4 2013 We first examined whether MBL modulated heat-killed (HK) C. albicans-induced cellular responses in phorbol 12-myristate 13-acetate (PMA)-activated human THP-1 macrophages. Tetradecanoylphorbol Acetate 132-135 GLI family zinc finger 2 Homo sapiens 153-158 23621670-5 2013 METHOD OF STUDY: THP-1 cells were cultured in two conditions and treated with phorbol 12-myristate 13-acetate (PMA) or MCSF. Tetradecanoylphorbol Acetate 78-109 GLI family zinc finger 2 Homo sapiens 17-22 24058654-7 2013 THP-1 monocytes were transformed into macrophages by 48h incubation with phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 73-104 GLI family zinc finger 2 Homo sapiens 0-5 23386263-6 2013 BDMC reduced oxLDL uptake most effectively, while CUR was the best inhibitor for CD36, scavenger receptor A, and lectin-like oxidized LDL receptor-1 expression during phorbol 12-myristate 13-acetate (PMA)-induced THP-1 differentiation. Tetradecanoylphorbol Acetate 167-198 GLI family zinc finger 2 Homo sapiens 213-218 23904362-4 2013 The lipopolysaccharide (LPS)-stimulated phrobol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophage models were established. Tetradecanoylphorbol Acetate 73-76 GLI family zinc finger 2 Homo sapiens 93-98 23621670-5 2013 METHOD OF STUDY: THP-1 cells were cultured in two conditions and treated with phorbol 12-myristate 13-acetate (PMA) or MCSF. Tetradecanoylphorbol Acetate 111-114 GLI family zinc finger 2 Homo sapiens 17-22 23589028-0 2013 Interferon-gamma enhances phorbol myristate acetate-induced cell attachment and tumor necrosis factor production via the NF-kappaB pathway in THP-1 human monocytic cells. Tetradecanoylphorbol Acetate 26-51 GLI family zinc finger 2 Homo sapiens 142-147 25654138-3 2013 Also, inhibitors of these protein activity suppressed PMA-induced morphological change of THP1 cells. Tetradecanoylphorbol Acetate 54-57 GLI family zinc finger 2 Homo sapiens 90-94 23589028-2 2013 THP-1 non-adherent human monocytic cells differentiate into plastic-adherent macrophages via alphaVbeta3 integrin, by ERK activation in the presence of phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 152-177 GLI family zinc finger 2 Homo sapiens 0-5 23589028-2 2013 THP-1 non-adherent human monocytic cells differentiate into plastic-adherent macrophages via alphaVbeta3 integrin, by ERK activation in the presence of phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 179-182 GLI family zinc finger 2 Homo sapiens 0-5 22955945-5 2013 RGD-anxA5 enhances engulfment of apoptotic cells by phorbol-12-myristate-13-acetate-stimulated THP-1 (human acute monocytic leukemia cell line) cells in vitro and resident peritoneal mouse macrophages in vivo. Tetradecanoylphorbol Acetate 52-83 GLI family zinc finger 2 Homo sapiens 95-100 23501100-2 2013 In this study, we revealed that the expression of PU.1 was increased and accompanied by downregulation of MT-1A expression during TPA-induced THP-1 monocyte differentiation. Tetradecanoylphorbol Acetate 130-133 GLI family zinc finger 2 Homo sapiens 142-147 23335792-4 2013 phorbol 12-myristate 13-acetate-activated THP-1 macrophages were transfected with negative control or MyD88 small interfering (si)RNA. Tetradecanoylphorbol Acetate 0-31 GLI family zinc finger 2 Homo sapiens 42-47 23408313-0 2013 Propyl gallate inhibits TPA-induced inflammation via the nuclear factor-kappaB pathway in human THP-1 monocytes. Tetradecanoylphorbol Acetate 24-27 GLI family zinc finger 2 Homo sapiens 96-101 23408313-2 2013 The present study examined the anti-inflammatory effect of PG on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in human THP-1 monocytes. Tetradecanoylphorbol Acetate 65-101 GLI family zinc finger 2 Homo sapiens 138-143 23408313-2 2013 The present study examined the anti-inflammatory effect of PG on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in human THP-1 monocytes. Tetradecanoylphorbol Acetate 103-106 GLI family zinc finger 2 Homo sapiens 138-143 23408313-4 2013 The application of PG significantly inhibited the nuclear translocation of p65, a subunit of nuclear factor-kappaB (NF-kappaB) and phosphorylation of p65 (Ser536) in TPA-treated THP-1 cells. Tetradecanoylphorbol Acetate 166-169 GLI family zinc finger 2 Homo sapiens 178-183 23408313-6 2013 These results indicate that PG inhibits the inflammatory response by blocking the NF-kappaB signaling pathway in TPA-induced THP-1 monocytes. Tetradecanoylphorbol Acetate 113-116 GLI family zinc finger 2 Homo sapiens 125-130 22610793-4 2013 The human monocyte THP-1 cells were differentiated to macrophage cells in the presence of phorbol 12-myristate13-acetate (PMA). Tetradecanoylphorbol Acetate 90-120 GLI family zinc finger 2 Homo sapiens 19-24 22610793-4 2013 The human monocyte THP-1 cells were differentiated to macrophage cells in the presence of phorbol 12-myristate13-acetate (PMA). Tetradecanoylphorbol Acetate 122-125 GLI family zinc finger 2 Homo sapiens 19-24 22493297-3 2012 By gain-of-function and loss-of-function experiments, we demonstrated that both miRNAs promote the phorbol 12-myristate 13-acetate-induced monocytic and all-trans-retinoic acid-induced granulocytic differentiation of HL-60, THP-1, or NB4 cells. Tetradecanoylphorbol Acetate 99-130 GLI family zinc finger 2 Homo sapiens 224-229 23286450-4 2012 Due to the effect of phorbol 12-myristate 13-acetate (PMA) on THP-1 monocytes, THP-1 monocytes would differentiate into macrophages and would then react with lipopolysaccharides (LPS), and the amount of NFkappaB increased in the THP-1 monocytes. Tetradecanoylphorbol Acetate 21-52 GLI family zinc finger 2 Homo sapiens 62-67 23286450-4 2012 Due to the effect of phorbol 12-myristate 13-acetate (PMA) on THP-1 monocytes, THP-1 monocytes would differentiate into macrophages and would then react with lipopolysaccharides (LPS), and the amount of NFkappaB increased in the THP-1 monocytes. Tetradecanoylphorbol Acetate 21-52 GLI family zinc finger 2 Homo sapiens 79-84 23286450-4 2012 Due to the effect of phorbol 12-myristate 13-acetate (PMA) on THP-1 monocytes, THP-1 monocytes would differentiate into macrophages and would then react with lipopolysaccharides (LPS), and the amount of NFkappaB increased in the THP-1 monocytes. Tetradecanoylphorbol Acetate 21-52 GLI family zinc finger 2 Homo sapiens 79-84 23286450-4 2012 Due to the effect of phorbol 12-myristate 13-acetate (PMA) on THP-1 monocytes, THP-1 monocytes would differentiate into macrophages and would then react with lipopolysaccharides (LPS), and the amount of NFkappaB increased in the THP-1 monocytes. Tetradecanoylphorbol Acetate 54-57 GLI family zinc finger 2 Homo sapiens 62-67 23286450-4 2012 Due to the effect of phorbol 12-myristate 13-acetate (PMA) on THP-1 monocytes, THP-1 monocytes would differentiate into macrophages and would then react with lipopolysaccharides (LPS), and the amount of NFkappaB increased in the THP-1 monocytes. Tetradecanoylphorbol Acetate 54-57 GLI family zinc finger 2 Homo sapiens 79-84 23286450-4 2012 Due to the effect of phorbol 12-myristate 13-acetate (PMA) on THP-1 monocytes, THP-1 monocytes would differentiate into macrophages and would then react with lipopolysaccharides (LPS), and the amount of NFkappaB increased in the THP-1 monocytes. Tetradecanoylphorbol Acetate 54-57 GLI family zinc finger 2 Homo sapiens 79-84 23286450-6 2012 In conclusion, microwave radiations were found to inhibit the activity functions of THP-1 monocytes stimulated with PMA and LPS. Tetradecanoylphorbol Acetate 116-119 GLI family zinc finger 2 Homo sapiens 84-89 23216989-7 2012 In contrast, PMA-induced THP-1 differentiation toward monocytic cells expressed CD11b+, and CD14+, but not CD123, and revealed exclusively IL-12 expression while stimulated by dengue-2. Tetradecanoylphorbol Acetate 13-16 GLI family zinc finger 2 Homo sapiens 25-30 23253724-4 2012 METHODS: We established three cell models; HSFb activated by TNF-alpha, THP-1 cells activated by phorbol 12-myristate 13-acetate (PMA) and an HSFb-THP-1 co-culture system. Tetradecanoylphorbol Acetate 97-128 GLI family zinc finger 2 Homo sapiens 72-77 22658257-6 2012 SAB reduced modified LDL (mLDL) uptake in a dose-dependent manner in phorbol-12-myristate-13-acetate (PMA)-stimulated THP-1 and RAW 264.7 cells. Tetradecanoylphorbol Acetate 69-100 GLI family zinc finger 2 Homo sapiens 118-123 22658257-6 2012 SAB reduced modified LDL (mLDL) uptake in a dose-dependent manner in phorbol-12-myristate-13-acetate (PMA)-stimulated THP-1 and RAW 264.7 cells. Tetradecanoylphorbol Acetate 102-105 GLI family zinc finger 2 Homo sapiens 118-123 21981079-3 2012 In this study, we evaluated the anti-inflammatory activity of Arisaema cum Bile extract on lipopolysaccharide (LPS)-induced inflammation in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages. Tetradecanoylphorbol Acetate 140-171 GLI family zinc finger 2 Homo sapiens 193-198 21981079-3 2012 In this study, we evaluated the anti-inflammatory activity of Arisaema cum Bile extract on lipopolysaccharide (LPS)-induced inflammation in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages. Tetradecanoylphorbol Acetate 173-176 GLI family zinc finger 2 Homo sapiens 193-198 22403404-3 2012 Because the biologically active Vpr is found in serum and cerebrospinal fluid of HIV-infected patients, we investigated the apoptotic effect of Vpr on monocyte-derived macrophages and phorbol 12-myristate 13-acetate-activated THP1 macrophages. Tetradecanoylphorbol Acetate 184-215 GLI family zinc finger 2 Homo sapiens 226-230 22480848-4 2012 They also inhibited the PMA/lipopolysaccharide-induced proinflammatory cytokines, IL-1beta and TNF-alpha production in human monocytic leukemia cells (THP-1), by 86%, 46% and 59.2% for IL-1beta and by 83.8%, 48.2% and 58.7% for TNF-alpha, respectively. Tetradecanoylphorbol Acetate 24-27 GLI family zinc finger 2 Homo sapiens 151-156 22351750-3 2012 Proteoglycan extracts of [(35)S]sulfate- and (35)S-trans amino acid-radiolabeled culture media from THP-1 monocytes induced to differentiate by treatment with phorbol myristate acetate revealed three major proteins of ~25, 90, and 100 kDa following chondroitin ABC lyase digestion. Tetradecanoylphorbol Acetate 159-184 GLI family zinc finger 2 Homo sapiens 100-105 21877189-2 2011 Changes in the inflammatory profiles of lipopolysaccharide (LPS)-activated phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophage models were investigated following SGlc treatment. Tetradecanoylphorbol Acetate 75-106 GLI family zinc finger 2 Homo sapiens 128-133 21877189-2 2011 Changes in the inflammatory profiles of lipopolysaccharide (LPS)-activated phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophage models were investigated following SGlc treatment. Tetradecanoylphorbol Acetate 108-111 GLI family zinc finger 2 Homo sapiens 128-133 21269946-2 2011 METHIDS: THP-1 monocytes were induced to differentiate into macrophages by a 24-h incubation with 160 nmol/L PMA. Tetradecanoylphorbol Acetate 109-112 GLI family zinc finger 2 Homo sapiens 9-14 21536764-2 2011 Successful transfection of THP-1 monocytes with subsequent phorbol 12-myristate 13-acetate (PMA)-induced differentiation into macrophages is not a trivial matter, because according to previous transfection protocols, cell viability is lost almost completely within 24 h of PMA treatment following transfection. Tetradecanoylphorbol Acetate 59-90 GLI family zinc finger 2 Homo sapiens 27-32 21536764-2 2011 Successful transfection of THP-1 monocytes with subsequent phorbol 12-myristate 13-acetate (PMA)-induced differentiation into macrophages is not a trivial matter, because according to previous transfection protocols, cell viability is lost almost completely within 24 h of PMA treatment following transfection. Tetradecanoylphorbol Acetate 92-95 GLI family zinc finger 2 Homo sapiens 27-32 21039753-0 2011 Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cdelta/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages. Tetradecanoylphorbol Acetate 201-226 GLI family zinc finger 2 Homo sapiens 235-240 21670559-3 2011 METHODS: Human THP-1 monocytes were preincubated with Phorbol-12-myristate- 13-acetate (PMA) and oxidized low density lipoprotein (ox-LDL) to form foam cells. Tetradecanoylphorbol Acetate 54-86 GLI family zinc finger 2 Homo sapiens 15-20 21670559-3 2011 METHODS: Human THP-1 monocytes were preincubated with Phorbol-12-myristate- 13-acetate (PMA) and oxidized low density lipoprotein (ox-LDL) to form foam cells. Tetradecanoylphorbol Acetate 88-91 GLI family zinc finger 2 Homo sapiens 15-20 21077177-1 2011 Leukemic cell lines, such as U937, THP-1, and HL60 cells, can differentiate into macrophages following exposure to various agents including 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro. Tetradecanoylphorbol Acetate 140-176 GLI family zinc finger 2 Homo sapiens 35-40 21077177-1 2011 Leukemic cell lines, such as U937, THP-1, and HL60 cells, can differentiate into macrophages following exposure to various agents including 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro. Tetradecanoylphorbol Acetate 178-181 GLI family zinc finger 2 Homo sapiens 35-40 21426336-5 2011 The effect of nampt on lipid accumulation was examined in phorbol myristate acetate-differentiated THP-1 and in primary monocyte-derived macrophages. Tetradecanoylphorbol Acetate 58-83 GLI family zinc finger 2 Homo sapiens 99-104 21530057-6 2011 Phorbol 12-myristate 13-acetate was used to induce the differentiation of human THP-1 monocytes into THP-1 macrophages. Tetradecanoylphorbol Acetate 0-31 GLI family zinc finger 2 Homo sapiens 80-85 21530057-6 2011 Phorbol 12-myristate 13-acetate was used to induce the differentiation of human THP-1 monocytes into THP-1 macrophages. Tetradecanoylphorbol Acetate 0-31 GLI family zinc finger 2 Homo sapiens 101-106 21134074-10 2011 The HUVEC co-cultured with TAM (PMA-treated THP-1 macrophages co-cultured with GC cells) expressed high levels of FXIIa. Tetradecanoylphorbol Acetate 32-35 GLI family zinc finger 2 Homo sapiens 44-49 20875052-3 2010 In this study, the impact of IFN-gamma treatment on phorbol-12-myristate-13-acetate-differentiated THP-1 cells infected with Mycobacterium bovis was investigated. Tetradecanoylphorbol Acetate 52-83 GLI family zinc finger 2 Homo sapiens 99-104 20979792-2 2010 METHODS: LDL from healthy volunteers was obtained by density-gradient ultracentrifugation and was oxidized by incubation with Cu2+ and ox-LDL was identified.Macrophages were induced from THP-1 cell by phorbol ester (PMA). Tetradecanoylphorbol Acetate 216-219 GLI family zinc finger 2 Homo sapiens 187-192 21127341-1 2010 In a previous work we showed that a 6 mT static magnetic field (SMF) interferes with monocyte/macrophage 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of promonocytes (U937 cells) and monocytes (THP-1 cells). Tetradecanoylphorbol Acetate 105-141 GLI family zinc finger 2 Homo sapiens 216-221 21127341-1 2010 In a previous work we showed that a 6 mT static magnetic field (SMF) interferes with monocyte/macrophage 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiation of promonocytes (U937 cells) and monocytes (THP-1 cells). Tetradecanoylphorbol Acetate 143-146 GLI family zinc finger 2 Homo sapiens 216-221 21127341-6 2010 Conversely, the rate of phagocytosis of apoptotic cells increased under SMF exposure, while the number of apoptotic cells bound to the plasma membrane of isolated human Kupffer cells, Raw 264.7 macrophages and TPA-differentiated THP-1 and U937 cells decreased. Tetradecanoylphorbol Acetate 210-213 GLI family zinc finger 2 Homo sapiens 229-234 20921526-3 2010 The myeloid-differentiating agents all-trans retinoic acid/PMA and histamine, the inflammatory mediator that inhibits promonocyte proliferation, induced an intracellular Ca(2+)-mediated PMV (as opposed to exosome) release from THP-1 promonocytes. Tetradecanoylphorbol Acetate 59-62 GLI family zinc finger 2 Homo sapiens 227-232 20945045-2 2010 THP-1 monocytes were induced into macrophages by 160 nmol/L phorbol myristate acetate (PMA) for 48 h, and then the macrophages were exposed to visfatin and PPARgamma activator rosiglitazone, respectively. Tetradecanoylphorbol Acetate 60-85 GLI family zinc finger 2 Homo sapiens 0-5 20945045-2 2010 THP-1 monocytes were induced into macrophages by 160 nmol/L phorbol myristate acetate (PMA) for 48 h, and then the macrophages were exposed to visfatin and PPARgamma activator rosiglitazone, respectively. Tetradecanoylphorbol Acetate 87-90 GLI family zinc finger 2 Homo sapiens 0-5 20673574-2 2010 Changes in the inflammatory profiles of lipopolysaccharide (LPS)-stimulated phrobol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophage models were investigated following pGlc treatment. Tetradecanoylphorbol Acetate 109-112 GLI family zinc finger 2 Homo sapiens 129-134 19747856-4 2010 METHODS: After 48 h of culture in the presence of phorbol myristate acetate, THP-1 monocytes differentiated to macrophages. Tetradecanoylphorbol Acetate 50-75 GLI family zinc finger 2 Homo sapiens 77-82 20607724-4 2010 12-O-tetradecanoylphorbol 13-acetate (TPA) suppressed expression of pdcd4 mRNA in human monocytic cell lines (U937, THP-1). Tetradecanoylphorbol Acetate 0-36 GLI family zinc finger 2 Homo sapiens 116-121 20607724-4 2010 12-O-tetradecanoylphorbol 13-acetate (TPA) suppressed expression of pdcd4 mRNA in human monocytic cell lines (U937, THP-1). Tetradecanoylphorbol Acetate 38-41 GLI family zinc finger 2 Homo sapiens 116-121 20176058-8 2010 When THP-1 and U937 cells differentiated into macrophages after incubation with 2-O-tetradecanoylphorbol-13-acetate (TPA), they secreted far greater amounts of salusin-beta-LI into the culture supernatant (3351.9 + or - 899.3 and 1545.8 + or - 183.3 fmol/10(5) cells per 24h). Tetradecanoylphorbol Acetate 117-120 GLI family zinc finger 2 Homo sapiens 5-10 20176058-9 2010 TPA treatment accelerated the processing of prosalusin into its cleaved fragments, suggesting that the increased secretion of salusin-beta-LI in THP-1-derived macrophages was caused by the enhanced intracellular processing of prosalusin. Tetradecanoylphorbol Acetate 0-3 GLI family zinc finger 2 Homo sapiens 145-150 19956200-2 2010 Using phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1 cells (an M5-AML containing the MLL-MLLT3 fusion), resulting in differentiation to an adherent monocytic phenotype. Tetradecanoylphorbol Acetate 6-31 GLI family zinc finger 2 Homo sapiens 80-85 20075180-9 2010 THP-1 cells differentiated into macrophage-like cells by treatment with PMA-internalized fluorescently labeled CRP. Tetradecanoylphorbol Acetate 72-75 GLI family zinc finger 2 Homo sapiens 0-5 19956200-2 2010 Using phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1 cells (an M5-AML containing the MLL-MLLT3 fusion), resulting in differentiation to an adherent monocytic phenotype. Tetradecanoylphorbol Acetate 33-36 GLI family zinc finger 2 Homo sapiens 80-85 19564157-4 2009 Here, we report that PAD2 is expressed in human monocytic leukaemia THP-1 cells during differentiation into macrophages by 12-O-tetradecanoylphorbol-13-acetate. Tetradecanoylphorbol Acetate 123-159 GLI family zinc finger 2 Homo sapiens 68-73 19737897-4 2010 In this study, we characterized the innate immune response elicited by PGA in the human monocytic cell line THP-1, which was differentiated into macrophages with phorbol 12-myristate 13-acetate (PMA) and human monocyte-derived dendritic cells (hMoDCs). Tetradecanoylphorbol Acetate 162-193 GLI family zinc finger 2 Homo sapiens 108-113 19887187-5 2009 In phorbol myristate acetate-differentiated THP-1 macrophages, pressure stimulated beta(1)-integrin T788/789 phosphorylation, but not S785 phosphorylation. Tetradecanoylphorbol Acetate 3-28 GLI family zinc finger 2 Homo sapiens 44-49 20137333-3 2009 The differentiation of THP-1 cells into macrophages was induced by phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 67-98 GLI family zinc finger 2 Homo sapiens 23-28 19907102-2 2009 METHODS: The present study focused on the effect of VPP on monocyte adhesion to endothelium under flow conditions using phorbol 12-myristate 13-acetate (PMA)-stimulated monocytic THP-1 cells. Tetradecanoylphorbol Acetate 120-151 GLI family zinc finger 2 Homo sapiens 179-184 19907102-2 2009 METHODS: The present study focused on the effect of VPP on monocyte adhesion to endothelium under flow conditions using phorbol 12-myristate 13-acetate (PMA)-stimulated monocytic THP-1 cells. Tetradecanoylphorbol Acetate 153-156 GLI family zinc finger 2 Homo sapiens 179-184 21305155-4 2009 In the present work, human monocyte cell line THP-1 was induced with phorbol myristate acetate to differentiate into a macrophage. Tetradecanoylphorbol Acetate 69-94 GLI family zinc finger 2 Homo sapiens 46-51 19907102-4 2009 PMA-induced up-regulation of beta1 and beta2 integrin activation in THP-1 cells was downregulated by VPP, which significantly suppressed only the PMA-induced phosphorylation of JNK (p<0.05) in THP-1 cells. Tetradecanoylphorbol Acetate 0-3 GLI family zinc finger 2 Homo sapiens 68-73 19907102-4 2009 PMA-induced up-regulation of beta1 and beta2 integrin activation in THP-1 cells was downregulated by VPP, which significantly suppressed only the PMA-induced phosphorylation of JNK (p<0.05) in THP-1 cells. Tetradecanoylphorbol Acetate 0-3 GLI family zinc finger 2 Homo sapiens 196-201 19907102-4 2009 PMA-induced up-regulation of beta1 and beta2 integrin activation in THP-1 cells was downregulated by VPP, which significantly suppressed only the PMA-induced phosphorylation of JNK (p<0.05) in THP-1 cells. Tetradecanoylphorbol Acetate 146-149 GLI family zinc finger 2 Homo sapiens 68-73 19907102-4 2009 PMA-induced up-regulation of beta1 and beta2 integrin activation in THP-1 cells was downregulated by VPP, which significantly suppressed only the PMA-induced phosphorylation of JNK (p<0.05) in THP-1 cells. Tetradecanoylphorbol Acetate 146-149 GLI family zinc finger 2 Homo sapiens 196-201 19907102-5 2009 In addition, preincubation of THP-1 with SP600125, a specific inhibitor of JNK, resulted in significant reduction of the PMA-induced adhesion of THP-1. Tetradecanoylphorbol Acetate 121-124 GLI family zinc finger 2 Homo sapiens 30-35 19907102-5 2009 In addition, preincubation of THP-1 with SP600125, a specific inhibitor of JNK, resulted in significant reduction of the PMA-induced adhesion of THP-1. Tetradecanoylphorbol Acetate 121-124 GLI family zinc finger 2 Homo sapiens 145-150 19694614-5 2009 In vitro studies using phorbol 12-myristyl 13-acetate (PMA) stimulated macrophage-like THP-1 (mTHP-1) cells were focused on cytotoxicity of both polymers and particles, and their potential to stimulate IL-8 release via the TLR-2 pathway. Tetradecanoylphorbol Acetate 55-58 GLI family zinc finger 2 Homo sapiens 87-92 19907102-3 2009 RESULTS: Pre-incubation of THP-1 cells with VPP (1 mM, 24 hours) significantly decreased the PMA-induced adhesion of THP-1 cells (p<0.05) to human umbilical vein endothelial cells (HUVECs). Tetradecanoylphorbol Acetate 93-96 GLI family zinc finger 2 Homo sapiens 27-32 19907102-3 2009 RESULTS: Pre-incubation of THP-1 cells with VPP (1 mM, 24 hours) significantly decreased the PMA-induced adhesion of THP-1 cells (p<0.05) to human umbilical vein endothelial cells (HUVECs). Tetradecanoylphorbol Acetate 93-96 GLI family zinc finger 2 Homo sapiens 117-122 19205902-0 2009 Copper egress is induced by PMA in human THP-1 monocytic cell line. Tetradecanoylphorbol Acetate 28-31 GLI family zinc finger 2 Homo sapiens 41-46 19781328-12 2009 RESULTS: Confocal microscopy showed THP-1 cells differentiated by 100 ng/ml of PMA for five days uptake more AcLDL than differentiated for two days. Tetradecanoylphorbol Acetate 79-82 GLI family zinc finger 2 Homo sapiens 36-41 19205902-3 2009 In current manuscript, using THP-1 cells, a human monocytic cell line, we found that ATP7A expression was increased in cells exposed to phorbol-12-myristate-13-acetate (PMA), a potent inducer of neovascularization and cancer. Tetradecanoylphorbol Acetate 136-167 GLI family zinc finger 2 Homo sapiens 29-34 19205902-3 2009 In current manuscript, using THP-1 cells, a human monocytic cell line, we found that ATP7A expression was increased in cells exposed to phorbol-12-myristate-13-acetate (PMA), a potent inducer of neovascularization and cancer. Tetradecanoylphorbol Acetate 169-172 GLI family zinc finger 2 Homo sapiens 29-34 19205902-6 2009 PMA treatment in THP-1 cells resulted in increased expression of matrix metalloproteinase (MMP) 9 and vascular endothelial growth factor receptor 1 (VEGFR1), whereas inhibition of ATP7A resulted in suppression of PMA-induced expression of VEGFR1, but not MMP9. Tetradecanoylphorbol Acetate 0-3 GLI family zinc finger 2 Homo sapiens 17-22 19205902-8 2009 Collectively, we demonstrate that PMA induces copper egress in THP-1 cells, which is regulated by ATP7A, and ATP7A regulates VEGFR1 expression. Tetradecanoylphorbol Acetate 34-37 GLI family zinc finger 2 Homo sapiens 63-68 19103313-2 2009 Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol myristate acetate (PMA) treatment, and can be converted into foam cells by exposure to oxidized low-density lipoprotein (oxLDL). Tetradecanoylphorbol Acetate 80-105 GLI family zinc finger 2 Homo sapiens 6-11 19337903-2 2009 Human monocytic cell line (THP-1 cell) was primed to differentiation into macrophages by phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 89-114 GLI family zinc finger 2 Homo sapiens 27-32 19337903-2 2009 Human monocytic cell line (THP-1 cell) was primed to differentiation into macrophages by phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 116-119 GLI family zinc finger 2 Homo sapiens 27-32 18843292-9 2009 Human THP-1 cell line cells, after treated with phorbol myristate acetate (PMA), differentiated to macrophages with M2 functional profiles. Tetradecanoylphorbol Acetate 48-73 GLI family zinc finger 2 Homo sapiens 6-11 18843292-9 2009 Human THP-1 cell line cells, after treated with phorbol myristate acetate (PMA), differentiated to macrophages with M2 functional profiles. Tetradecanoylphorbol Acetate 75-78 GLI family zinc finger 2 Homo sapiens 6-11 18843292-10 2009 Coculture with PMA-treated THP-1 macrophages induced COX-2-dependent release of matrix metalloproteinase-9 and subsequent increased invasion of BCC cells. Tetradecanoylphorbol Acetate 15-18 GLI family zinc finger 2 Homo sapiens 27-32 19232538-2 2009 Induction of THP-1 monocyte differentiation by phorbol 12-myristate 13-acetate (PMA) markedly increased SVCT2 mRNA, protein, and function. Tetradecanoylphorbol Acetate 47-78 GLI family zinc finger 2 Homo sapiens 13-18 19232538-2 2009 Induction of THP-1 monocyte differentiation by phorbol 12-myristate 13-acetate (PMA) markedly increased SVCT2 mRNA, protein, and function. Tetradecanoylphorbol Acetate 80-83 GLI family zinc finger 2 Homo sapiens 13-18 19103313-2 2009 Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol myristate acetate (PMA) treatment, and can be converted into foam cells by exposure to oxidized low-density lipoprotein (oxLDL). Tetradecanoylphorbol Acetate 107-110 GLI family zinc finger 2 Homo sapiens 6-11 18575575-7 2008 THP-1 cells were magnetically labeled with FePro, differentiated with 100 nM of phorbol ester, 12-Myristate-13-acetate (TPA) and stimulated with 100 ng/ml of LPS. Tetradecanoylphorbol Acetate 120-123 GLI family zinc finger 2 Homo sapiens 0-5 18496024-9 2008 CONCLUSIONS: Th2- and Th1-adjuvant activities can be quantitatively evaluated by using PMA-treated THP-1 cells and PMA-treated/forskolin-stimulated THP-1 cells, respectively. Tetradecanoylphorbol Acetate 87-90 GLI family zinc finger 2 Homo sapiens 99-104 18496024-9 2008 CONCLUSIONS: Th2- and Th1-adjuvant activities can be quantitatively evaluated by using PMA-treated THP-1 cells and PMA-treated/forskolin-stimulated THP-1 cells, respectively. Tetradecanoylphorbol Acetate 115-118 GLI family zinc finger 2 Homo sapiens 148-153 18544595-4 2008 METHODS: THP-1 monocytes were differentiated with phorbol myristate acetate (PMA) and compared with unstimulated cells for: (i) moxifloxacin and levofloxacin accumulation; and (ii) activity against phagocytosed L. monocytogenes and S. aureus (5 h contact). Tetradecanoylphorbol Acetate 77-80 GLI family zinc finger 2 Homo sapiens 9-14 17920620-3 2007 The assay was conducted using a human monocytic leukemia cell line, THP-1, treated with either 12-O-tetradecanoylphorbol 13-acetate or cytokines, such as tumor necrosis factor-alpha and interferon-gamma. Tetradecanoylphorbol Acetate 95-131 GLI family zinc finger 2 Homo sapiens 68-73 18435438-3 2008 Phorbol-12-myristic-13-acetate (PMA)-treated THP-1 monocytes differentiated into macrophages and synthesized lipoprotein lipase (LPL), the major enzyme for hydrolysis of triglycerides. Tetradecanoylphorbol Acetate 32-35 GLI family zinc finger 2 Homo sapiens 45-50 18427282-3 2008 Atorvastatin from 2 microM to 40 microM dose-dependently inhibited ABCA1 expression in human monocyte-derived macrophages and phorbol 12-myristate 13-acetate (PMA)-stimulated THP-1 monocytes. Tetradecanoylphorbol Acetate 126-157 GLI family zinc finger 2 Homo sapiens 175-180 18427282-3 2008 Atorvastatin from 2 microM to 40 microM dose-dependently inhibited ABCA1 expression in human monocyte-derived macrophages and phorbol 12-myristate 13-acetate (PMA)-stimulated THP-1 monocytes. Tetradecanoylphorbol Acetate 159-162 GLI family zinc finger 2 Homo sapiens 175-180 17920036-0 2007 Regulation of p21Waf1 expression and TNFalpha biosynthesis by glutathione modulators in PMA induced-THP1 differentiation: involvement of JNK and ERK pathways. Tetradecanoylphorbol Acetate 88-91 GLI family zinc finger 2 Homo sapiens 100-104 17573821-5 2007 Tumor necrosis factor alpha (TNFalpha) secretion was significantly inhibited in both primary microglia and THP-1 cells differentiated for 72 h in the presence of PMA to induce a macrophage-like phenotype. Tetradecanoylphorbol Acetate 162-165 GLI family zinc finger 2 Homo sapiens 107-112 17920036-4 2007 We observed an increase of p21Waf1 expression and TNFalpha biosynthesis in the THP1 monocyte/macrophage cell line treated with PMA. Tetradecanoylphorbol Acetate 127-130 GLI family zinc finger 2 Homo sapiens 79-83 17407144-2 2007 Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol myristate acetate (PMA) and can then be converted into foam cells by exposure to oxidized low-density lipoprotein (oxLDL). Tetradecanoylphorbol Acetate 80-105 GLI family zinc finger 2 Homo sapiens 6-11 17407144-2 2007 Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol myristate acetate (PMA) and can then be converted into foam cells by exposure to oxidized low-density lipoprotein (oxLDL). Tetradecanoylphorbol Acetate 107-110 GLI family zinc finger 2 Homo sapiens 6-11 17055343-4 2007 The effects of pioglitazone and resveratrol were reversed by pretreatment of THP-1 cells with a PPARgamma antagonist, GW9662, prior to PMA induction. Tetradecanoylphorbol Acetate 135-138 GLI family zinc finger 2 Homo sapiens 77-82 17184493-4 2006 In order to systematically investigate these effects at a cellular level, we investigated gene expression in phorbol myristate acetate (PMA)-activated and non-activated human THP-1 monocytes in response to statins using cDNA arrays. Tetradecanoylphorbol Acetate 109-134 GLI family zinc finger 2 Homo sapiens 175-180 17334670-1 2007 OBJECTIVES: The differentiation of THP-1 monocytes into macrophages is mainly conducted at a phorbol 12-myristate 13-acetate (PMA) concentration of 10-400 ng/ml. Tetradecanoylphorbol Acetate 93-124 GLI family zinc finger 2 Homo sapiens 35-40 17334670-1 2007 OBJECTIVES: The differentiation of THP-1 monocytes into macrophages is mainly conducted at a phorbol 12-myristate 13-acetate (PMA) concentration of 10-400 ng/ml. Tetradecanoylphorbol Acetate 126-129 GLI family zinc finger 2 Homo sapiens 35-40 17348203-1 2006 In the present study, we measured the antibody-catalyzed 03 formation from THP-1 monocytes activated by phorbol myristate acetate (PMA) by indigo carmine bleaching reaction test, and the accumulation of cholesterol in THP-1 monocytes by fluorescence spectrophotometric method, and analyzed the cholesterol ozonation product 5,6-secosterol by high-performance liquid chromatography (HPLC), to explore the potential effect of antibody-catalyzed water oxidation on pathogenesis of atherosclerosis. Tetradecanoylphorbol Acetate 104-129 GLI family zinc finger 2 Homo sapiens 75-80 17348203-1 2006 In the present study, we measured the antibody-catalyzed 03 formation from THP-1 monocytes activated by phorbol myristate acetate (PMA) by indigo carmine bleaching reaction test, and the accumulation of cholesterol in THP-1 monocytes by fluorescence spectrophotometric method, and analyzed the cholesterol ozonation product 5,6-secosterol by high-performance liquid chromatography (HPLC), to explore the potential effect of antibody-catalyzed water oxidation on pathogenesis of atherosclerosis. Tetradecanoylphorbol Acetate 131-134 GLI family zinc finger 2 Homo sapiens 75-80 17348203-1 2006 In the present study, we measured the antibody-catalyzed 03 formation from THP-1 monocytes activated by phorbol myristate acetate (PMA) by indigo carmine bleaching reaction test, and the accumulation of cholesterol in THP-1 monocytes by fluorescence spectrophotometric method, and analyzed the cholesterol ozonation product 5,6-secosterol by high-performance liquid chromatography (HPLC), to explore the potential effect of antibody-catalyzed water oxidation on pathogenesis of atherosclerosis. Tetradecanoylphorbol Acetate 131-134 GLI family zinc finger 2 Homo sapiens 218-223 17184493-4 2006 In order to systematically investigate these effects at a cellular level, we investigated gene expression in phorbol myristate acetate (PMA)-activated and non-activated human THP-1 monocytes in response to statins using cDNA arrays. Tetradecanoylphorbol Acetate 136-139 GLI family zinc finger 2 Homo sapiens 175-180 15625302-1 2005 We have previously demonstrated that constant 20 mmHg extracellular pressure increases serum-opsonized latex bead phagocytosis by phorbol 12-myristate 13-acetate (PMA)- differentiated THP-1 macrophages in part by inhibiting focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK). Tetradecanoylphorbol Acetate 130-161 GLI family zinc finger 2 Homo sapiens 184-189 17067317-6 2006 These cellular responses were also observed when the THP-1 cells were treated with phorbol-12 myristate-13 acetate (PMA), which is known to induce macrophage differentiation. Tetradecanoylphorbol Acetate 83-114 GLI family zinc finger 2 Homo sapiens 53-58 17067317-6 2006 These cellular responses were also observed when the THP-1 cells were treated with phorbol-12 myristate-13 acetate (PMA), which is known to induce macrophage differentiation. Tetradecanoylphorbol Acetate 116-119 GLI family zinc finger 2 Homo sapiens 53-58 16484557-4 2006 Incubation of THP-1 cells with Hcy (200 micromol/L) for 72 h in the presence of phorbol 12-myristate 13-acetate (PMA) (10 nmol/L) caused a 37.8+/-5.2% increase in CD36 expression compared with PMA-stimulated cells without Hcy (P<0.01). Tetradecanoylphorbol Acetate 113-116 GLI family zinc finger 2 Homo sapiens 14-19 16484557-4 2006 Incubation of THP-1 cells with Hcy (200 micromol/L) for 72 h in the presence of phorbol 12-myristate 13-acetate (PMA) (10 nmol/L) caused a 37.8+/-5.2% increase in CD36 expression compared with PMA-stimulated cells without Hcy (P<0.01). Tetradecanoylphorbol Acetate 193-196 GLI family zinc finger 2 Homo sapiens 14-19 16484557-7 2006 AGE also inhibited DiI-labeled OxLDL uptake into PMA-stimulated THP-1 cells by 85.6+/-2.8% (P<0.01), but Hcy had no effects on it. Tetradecanoylphorbol Acetate 49-52 GLI family zinc finger 2 Homo sapiens 64-69 15904490-5 2005 After 24 hours of PMA-induced monocyte differentiation, the mean fluorescence intensity of CD147 in differentiated THP-1 cells (289.61 +/- 31.63) was higher than that of the undifferentiated THP-1 cells (205.1 +/- 19.25). Tetradecanoylphorbol Acetate 18-21 GLI family zinc finger 2 Homo sapiens 115-120 15904490-5 2005 After 24 hours of PMA-induced monocyte differentiation, the mean fluorescence intensity of CD147 in differentiated THP-1 cells (289.61 +/- 31.63) was higher than that of the undifferentiated THP-1 cells (205.1 +/- 19.25). Tetradecanoylphorbol Acetate 18-21 GLI family zinc finger 2 Homo sapiens 191-196 16313911-2 2006 Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol myristate acetate (PMA) treatment, and can then be converted into foam cells by exposure to oxidized low-density lipoprotein (oxLDL). Tetradecanoylphorbol Acetate 80-105 GLI family zinc finger 2 Homo sapiens 6-11 16313911-2 2006 Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol myristate acetate (PMA) treatment, and can then be converted into foam cells by exposure to oxidized low-density lipoprotein (oxLDL). Tetradecanoylphorbol Acetate 107-110 GLI family zinc finger 2 Homo sapiens 6-11 16787983-4 2006 DESIGN: Human monocytic THP1-cells were differentiated and activated by IFNgamma and a secondary stimulus, such as lipopolysaccharide or phorbol myristate acetate. Tetradecanoylphorbol Acetate 137-162 GLI family zinc finger 2 Homo sapiens 24-28 16787983-8 2006 In contrast, in phorbol myristate acetate-differentiated THP1 macrophages, IFNgamma alone induces 1alpha-hydroxylase and to much higher levels. Tetradecanoylphorbol Acetate 16-41 GLI family zinc finger 2 Homo sapiens 57-61 16982432-2 2006 METHODS: Monocytic THP-1 cells were cultured in the presence of 100 nmol/L phorbol myristate acetate (PMA) for 72 h to transform the cells into THP-1 macrophages. Tetradecanoylphorbol Acetate 75-100 GLI family zinc finger 2 Homo sapiens 19-24 16982432-2 2006 METHODS: Monocytic THP-1 cells were cultured in the presence of 100 nmol/L phorbol myristate acetate (PMA) for 72 h to transform the cells into THP-1 macrophages. Tetradecanoylphorbol Acetate 75-100 GLI family zinc finger 2 Homo sapiens 144-149 16982432-2 2006 METHODS: Monocytic THP-1 cells were cultured in the presence of 100 nmol/L phorbol myristate acetate (PMA) for 72 h to transform the cells into THP-1 macrophages. Tetradecanoylphorbol Acetate 102-105 GLI family zinc finger 2 Homo sapiens 19-24 16982432-2 2006 METHODS: Monocytic THP-1 cells were cultured in the presence of 100 nmol/L phorbol myristate acetate (PMA) for 72 h to transform the cells into THP-1 macrophages. Tetradecanoylphorbol Acetate 102-105 GLI family zinc finger 2 Homo sapiens 144-149 16630555-2 2006 A human monocytic cell line, THP-1, differentiated to be neutrophil-like cells generated superoxide with increase in intracellular Ca2+ concentration when stimulated with formyl-methionyl-leucyl-phenylalanine (fMLP) whereas PMA, phorbol ester-stimulated superoxide response occurred without change in [Ca2+]i. Tetradecanoylphorbol Acetate 224-227 GLI family zinc finger 2 Homo sapiens 29-34 16761100-3 2006 Our results showed that both H2O2 and O3 were produced in human leukemia THP-1 monocytes incubated with human immunoglobulin G and phorbol myristate acetate. Tetradecanoylphorbol Acetate 131-156 GLI family zinc finger 2 Homo sapiens 73-78 16484557-4 2006 Incubation of THP-1 cells with Hcy (200 micromol/L) for 72 h in the presence of phorbol 12-myristate 13-acetate (PMA) (10 nmol/L) caused a 37.8+/-5.2% increase in CD36 expression compared with PMA-stimulated cells without Hcy (P<0.01). Tetradecanoylphorbol Acetate 80-111 GLI family zinc finger 2 Homo sapiens 14-19 15625302-1 2005 We have previously demonstrated that constant 20 mmHg extracellular pressure increases serum-opsonized latex bead phagocytosis by phorbol 12-myristate 13-acetate (PMA)- differentiated THP-1 macrophages in part by inhibiting focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK). Tetradecanoylphorbol Acetate 163-166 GLI family zinc finger 2 Homo sapiens 184-189 11938511-4 2002 Suboptimal stimulation with 4 beta-phorbol-12-myristate-13-acetate (PMA) plus particles resulted in a synergistic release of superoxide (O2-), however, and a low-level production of nitric oxide small middle dot by THP-1 macrophages. Tetradecanoylphorbol Acetate 28-66 GLI family zinc finger 2 Homo sapiens 215-220 16463649-4 2005 The differentiation of THP-1 cells into macrophages (MPs) was induced by using myristate acetate (PMA) for 48 h. The macrophages were then incubated with oxidized LDL (ox-LDL) to generate foam cells (FCs). Tetradecanoylphorbol Acetate 98-101 GLI family zinc finger 2 Homo sapiens 23-28 15153668-0 2004 A comparison of differences in the gene expression profiles of phorbol 12-myristate 13-acetate differentiated THP-1 cells and human monocyte-derived macrophage. Tetradecanoylphorbol Acetate 63-94 GLI family zinc finger 2 Homo sapiens 110-115 14576072-6 2003 Several of these changes were also present in PMA-stimulated THP-1 macrophages in vitro. Tetradecanoylphorbol Acetate 46-49 GLI family zinc finger 2 Homo sapiens 61-66 12875367-4 2003 Phorbol-12-myristate-13-acetate-(PMA)-treated THP-1 cells were exposed to the same conditions. Tetradecanoylphorbol Acetate 0-31 GLI family zinc finger 2 Homo sapiens 46-51 12875367-4 2003 Phorbol-12-myristate-13-acetate-(PMA)-treated THP-1 cells were exposed to the same conditions. Tetradecanoylphorbol Acetate 33-36 GLI family zinc finger 2 Homo sapiens 46-51 12417276-2 2002 Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol myristate acetate (PMA) treatment, and can then be converted into foam cells by exposure to oxidized low-density lipoprotein (oxLDL). Tetradecanoylphorbol Acetate 80-105 GLI family zinc finger 2 Homo sapiens 6-11 12417276-2 2002 Human THP-1 monocytic cells can be induced to differentiate into macrophages by phorbol myristate acetate (PMA) treatment, and can then be converted into foam cells by exposure to oxidized low-density lipoprotein (oxLDL). Tetradecanoylphorbol Acetate 107-110 GLI family zinc finger 2 Homo sapiens 6-11 15528304-4 2005 Adiponectin cleavage into several carboxyl-terminal fragments containing the globular domain was observed in the medium of phorbol 12-myristate 13-acetate-stimulated monocytic cell lines THP-1 and U937. Tetradecanoylphorbol Acetate 123-154 GLI family zinc finger 2 Homo sapiens 187-192 14573775-2 2003 In this study, TP mRNA and enzyme activity were found to be up-regulated upon the induction of differentiation of the human monocyte cell line THP-1 by phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 152-183 GLI family zinc finger 2 Homo sapiens 143-148 14573775-2 2003 In this study, TP mRNA and enzyme activity were found to be up-regulated upon the induction of differentiation of the human monocyte cell line THP-1 by phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 185-188 GLI family zinc finger 2 Homo sapiens 143-148 12496173-3 2003 The present study evaluated the potential for phorbol myristate acetate-differentiated THP-1 cells to mimic this response of primary macrophages. Tetradecanoylphorbol Acetate 46-71 GLI family zinc finger 2 Homo sapiens 87-92 12193227-6 2002 Moreover, they inhibited chemotaxis, phagocytosis of Escherichia coli and PMA-stimulated production of hydrogen peroxide in THP-1 differentiated to macrophage-like cells. Tetradecanoylphorbol Acetate 74-77 GLI family zinc finger 2 Homo sapiens 124-129 11874493-2 2002 Phorbol-12-myristate-13-acetate differentiated THP-1 into macrophage-like cells. Tetradecanoylphorbol Acetate 0-31 GLI family zinc finger 2 Homo sapiens 47-52 11938511-4 2002 Suboptimal stimulation with 4 beta-phorbol-12-myristate-13-acetate (PMA) plus particles resulted in a synergistic release of superoxide (O2-), however, and a low-level production of nitric oxide small middle dot by THP-1 macrophages. Tetradecanoylphorbol Acetate 68-71 GLI family zinc finger 2 Homo sapiens 215-220 11563864-3 2001 Using a model of human promonocytic cells (THP-1), the cells were differentiated into macrophages by preincubation with C. pneumoniae extract, and further stimulated by phorbol myristate acetate. Tetradecanoylphorbol Acetate 169-194 GLI family zinc finger 2 Homo sapiens 43-48 11562079-1 2001 We show that radicicol, an anti-fungal agent, inhibits interleukin-8 (IL-8) production by the human monocyte line THP-1 in response to phorbol-12-myristate-13-acetate/lipopolysaccharide (PMA/LPS). Tetradecanoylphorbol Acetate 135-166 GLI family zinc finger 2 Homo sapiens 114-119 11388647-6 2001 When phorbol 12-myristate 13-acetate-treated THP-1 and J774A.1 cells were incubated in the medium containing 20% of serum from rats administered R-755, the ACAT activities of the cells were inhibited. Tetradecanoylphorbol Acetate 5-36 GLI family zinc finger 2 Homo sapiens 45-50 11145836-4 2001 The IL-1H transcripts were stimulated by phorbol ester (PMA) in human cell lines (A431, THP-1 and KG-1) and peripheral blood mononuclear cells (HPBMC) and dendritic cells (NHDC). Tetradecanoylphorbol Acetate 56-59 GLI family zinc finger 2 Homo sapiens 88-93 9931126-3 1999 THP1, a human monocytic leukemia cell line, was differentiated to macrophages by adding of phorbol 12-myristate 13-acetate for 24 hours. Tetradecanoylphorbol Acetate 91-122 GLI family zinc finger 2 Homo sapiens 0-4 9890556-7 1999 Stimulation of THP-1 cells with LPS + phorbol myristate acetate increased the percentage of cells expressing pro-TNFalpha by 10-fold. Tetradecanoylphorbol Acetate 38-63 GLI family zinc finger 2 Homo sapiens 15-20 11810558-7 2000 We also examined the uptake of the two fluoroquinolones in phorbol 12 myristate 13-acetate (PMA)-stimulated adherent THP-1 cells (THP-1 macrophages). Tetradecanoylphorbol Acetate 59-90 GLI family zinc finger 2 Homo sapiens 117-122 11810558-7 2000 We also examined the uptake of the two fluoroquinolones in phorbol 12 myristate 13-acetate (PMA)-stimulated adherent THP-1 cells (THP-1 macrophages). Tetradecanoylphorbol Acetate 92-95 GLI family zinc finger 2 Homo sapiens 117-122 11810558-7 2000 We also examined the uptake of the two fluoroquinolones in phorbol 12 myristate 13-acetate (PMA)-stimulated adherent THP-1 cells (THP-1 macrophages). Tetradecanoylphorbol Acetate 92-95 GLI family zinc finger 2 Homo sapiens 130-135 10570263-4 1999 PMA/ionomycin stimulation of monocytic cell lines (U937, THP-1, and MM6), but not of neutrophils, resulted in release of sCD89. Tetradecanoylphorbol Acetate 0-3 GLI family zinc finger 2 Homo sapiens 57-62 10515876-4 1999 Activation of HUVEC with 100 nmol/L phorbol myristate acetate (PMA) increased THP-1 cell adhesion at shear rates less than 400 s(-1). Tetradecanoylphorbol Acetate 36-61 GLI family zinc finger 2 Homo sapiens 78-83 10515876-4 1999 Activation of HUVEC with 100 nmol/L phorbol myristate acetate (PMA) increased THP-1 cell adhesion at shear rates less than 400 s(-1). Tetradecanoylphorbol Acetate 63-66 GLI family zinc finger 2 Homo sapiens 78-83 10446065-4 1999 When treated with IL-6, macrophages derived from peripheral monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells showed significantly reduced uptake and/or binding of the MSR ligand, acetylated LDL. Tetradecanoylphorbol Acetate 74-105 GLI family zinc finger 2 Homo sapiens 127-132 10446065-4 1999 When treated with IL-6, macrophages derived from peripheral monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells showed significantly reduced uptake and/or binding of the MSR ligand, acetylated LDL. Tetradecanoylphorbol Acetate 107-110 GLI family zinc finger 2 Homo sapiens 127-132 10233362-5 1999 Consistent with this observation, when THP-1 monocytic and HL-60 promyelocytic leukaemia cells expressing Ret were differentiated toward macrophages or granulocytes by treatment of 12-O-tetradecanoylphorbol-13-acetate (TPA) or all-trans retinoic acid (RA), Ret expression strikingly decreased during differentiation. Tetradecanoylphorbol Acetate 181-217 GLI family zinc finger 2 Homo sapiens 39-44 10233362-5 1999 Consistent with this observation, when THP-1 monocytic and HL-60 promyelocytic leukaemia cells expressing Ret were differentiated toward macrophages or granulocytes by treatment of 12-O-tetradecanoylphorbol-13-acetate (TPA) or all-trans retinoic acid (RA), Ret expression strikingly decreased during differentiation. Tetradecanoylphorbol Acetate 219-222 GLI family zinc finger 2 Homo sapiens 39-44 10404956-5 1999 Differentiated THP-1, induced by adding phorbol 12-myristate 13-acetate for 24 h, were used as macrophages. Tetradecanoylphorbol Acetate 40-71 GLI family zinc finger 2 Homo sapiens 15-20 9809627-2 1998 Pretreatment of HL-60 or THP-1 cells with phorbol myristate acetate (PMA) enhanced their capacity to induce IL-8 production by T98G cells. Tetradecanoylphorbol Acetate 42-67 GLI family zinc finger 2 Homo sapiens 25-30 9528941-14 1998 On the other hand, dibutyryl cAMP suppressed PMA-stimulated expression of exon I.6 in THP-1 cells and adipose stromal cells. Tetradecanoylphorbol Acetate 45-48 GLI family zinc finger 2 Homo sapiens 86-91 9809627-2 1998 Pretreatment of HL-60 or THP-1 cells with phorbol myristate acetate (PMA) enhanced their capacity to induce IL-8 production by T98G cells. Tetradecanoylphorbol Acetate 69-72 GLI family zinc finger 2 Homo sapiens 25-30 9599015-3 1998 Retinoic acid exerted synergistic effects on AM secretion from THP-1 and HL-60 cells when administered with tumor necrosis factor-alpha, lipopolysaccharide or 12-O-tetradecanoyl phorbol-13-acetate. Tetradecanoylphorbol Acetate 159-196 GLI family zinc finger 2 Homo sapiens 63-68 9636198-5 1998 PPARgamma mRNA expression was also induced in primary macrophages and THP-1 monocytic leukemia cells by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA). Tetradecanoylphorbol Acetate 122-158 GLI family zinc finger 2 Homo sapiens 70-75 9636198-5 1998 PPARgamma mRNA expression was also induced in primary macrophages and THP-1 monocytic leukemia cells by the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA). Tetradecanoylphorbol Acetate 160-163 GLI family zinc finger 2 Homo sapiens 70-75 9528978-5 1998 We used a human monocytic leukemia cell line, THP-1, which differentiates into macrophages when treated with phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 109-140 GLI family zinc finger 2 Homo sapiens 46-51 9528978-6 1998 The coculture of EC and THP-1-derived macrophages enhanced CNP secretion by more than 10-fold compared with the single culture of EC or the coculture of EC and THP-1 without phorbol 12-myristate 13-acetate treatment. Tetradecanoylphorbol Acetate 174-205 GLI family zinc finger 2 Homo sapiens 24-29 9430696-6 1998 The culture medium of subtype THP-1 cells treated with 12-O-tetradecanoylphorbol-13-acetate inhibited the uptake of Ac-LDL and the expression of ScR in parent THP-1 cells. Tetradecanoylphorbol Acetate 55-91 GLI family zinc finger 2 Homo sapiens 30-35 9430696-6 1998 The culture medium of subtype THP-1 cells treated with 12-O-tetradecanoylphorbol-13-acetate inhibited the uptake of Ac-LDL and the expression of ScR in parent THP-1 cells. Tetradecanoylphorbol Acetate 55-91 GLI family zinc finger 2 Homo sapiens 159-164 9430696-7 1998 After a 48-h incubation in the culture medium containing 12-O-tetradecanoylphorbol-13-acetate, the culture medium of differentiated subtype THP-1 cells contained 6.9 ng/ml transforming growth factor (TGF)-beta 1, while that of parent THP-1 cells secreted below detection level, which was less than 3 ng/ml. Tetradecanoylphorbol Acetate 57-93 GLI family zinc finger 2 Homo sapiens 140-145 9430696-7 1998 After a 48-h incubation in the culture medium containing 12-O-tetradecanoylphorbol-13-acetate, the culture medium of differentiated subtype THP-1 cells contained 6.9 ng/ml transforming growth factor (TGF)-beta 1, while that of parent THP-1 cells secreted below detection level, which was less than 3 ng/ml. Tetradecanoylphorbol Acetate 57-93 GLI family zinc finger 2 Homo sapiens 234-239 9367827-1 1997 The human monocytic leukemic cell line, THP-1, which differentiates toward macrophages in response to phorbol 12-myristate 13-acetate (PMA) was investigated for its ability to produce granulocyte colony-stimulating factor (G-CSF). Tetradecanoylphorbol Acetate 102-133 GLI family zinc finger 2 Homo sapiens 40-45 9367827-1 1997 The human monocytic leukemic cell line, THP-1, which differentiates toward macrophages in response to phorbol 12-myristate 13-acetate (PMA) was investigated for its ability to produce granulocyte colony-stimulating factor (G-CSF). Tetradecanoylphorbol Acetate 135-138 GLI family zinc finger 2 Homo sapiens 40-45 9367827-3 1997 However, when combined, PMA and Dex synergistically stimulated THP-1 cells to produce G-CSF. Tetradecanoylphorbol Acetate 24-27 GLI family zinc finger 2 Homo sapiens 63-68 9367827-5 1997 Further experiments demonstrated that in THP-1 cells pretreated with PMA, Dex potently synergized with IL-1 to stimulate G-CSF production. Tetradecanoylphorbol Acetate 69-72 GLI family zinc finger 2 Homo sapiens 41-46 9307240-3 1997 Cultured human monocytic THP-1 cells increased their glutamate secretion following 18 and 68 h exposure to the inflammatory mediators zymosan, phorbol myristate acetate (PMA), lipopolysaccharide, interferon-gamma, tumor-necrosis factor-alpha and interleukin-1beta. Tetradecanoylphorbol Acetate 143-168 GLI family zinc finger 2 Homo sapiens 25-30 9307240-3 1997 Cultured human monocytic THP-1 cells increased their glutamate secretion following 18 and 68 h exposure to the inflammatory mediators zymosan, phorbol myristate acetate (PMA), lipopolysaccharide, interferon-gamma, tumor-necrosis factor-alpha and interleukin-1beta. Tetradecanoylphorbol Acetate 170-173 GLI family zinc finger 2 Homo sapiens 25-30 9443579-3 1997 Stimulation by phorbol myristate acetate (PMA) (100 ng/ml for 48 h) induced TNF alpha secretion in THP-1 and Namalwa cells (100 to 300 pg/ml). Tetradecanoylphorbol Acetate 15-40 GLI family zinc finger 2 Homo sapiens 99-104 9443579-3 1997 Stimulation by phorbol myristate acetate (PMA) (100 ng/ml for 48 h) induced TNF alpha secretion in THP-1 and Namalwa cells (100 to 300 pg/ml). Tetradecanoylphorbol Acetate 42-45 GLI family zinc finger 2 Homo sapiens 99-104 8908154-5 1996 Lovastatin (5-15 microM) caused a significant dose-related reduction in steady state levels of type-I SCR mRNA in phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells. Tetradecanoylphorbol Acetate 114-145 GLI family zinc finger 2 Homo sapiens 160-165 9024988-6 1996 THP-1 cells were primed with a phorbol ester (PMA) for 24 h, then they were cultured for 4 and 24 h in the presence of inactivated culture supernatant of dengue infected AP61 cells or control preparations. Tetradecanoylphorbol Acetate 46-49 GLI family zinc finger 2 Homo sapiens 0-5 8908154-5 1996 Lovastatin (5-15 microM) caused a significant dose-related reduction in steady state levels of type-I SCR mRNA in phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells. Tetradecanoylphorbol Acetate 147-150 GLI family zinc finger 2 Homo sapiens 160-165 8870667-0 1996 Post-transcriptional regulation of H-ferritin gene expression in human monocytic THP-1 cells by protein kinase C. The mRNA coding for H-ferritin was highly induced in human monocytic THP-1 cells following treatment with phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 220-251 GLI family zinc finger 2 Homo sapiens 81-86 8870667-0 1996 Post-transcriptional regulation of H-ferritin gene expression in human monocytic THP-1 cells by protein kinase C. The mRNA coding for H-ferritin was highly induced in human monocytic THP-1 cells following treatment with phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 220-251 GLI family zinc finger 2 Homo sapiens 183-188 8753812-5 1996 It has been previously reported that IL-1 potently synergizes with RA to stimulate G-CSF production by THP-1 cells pretreated with PMA Using synthetic ligands to RA receptors (RAR) and retinoid X receptors (RXR) that selectively bind and activate RAR-RXR and RXR-RXR dimers respectively, we showed that the ability of RA to synergize with IL-1 was signaled through RAR-RXR heterodimer pathway. Tetradecanoylphorbol Acetate 131-134 GLI family zinc finger 2 Homo sapiens 103-108 8805854-5 1996 Phorbol myristate acetate (PMA) induced macrophage-like differentiation and up-regulated the gamma c chain mRNA expression in THP-1 cells. Tetradecanoylphorbol Acetate 0-25 GLI family zinc finger 2 Homo sapiens 126-131 8805854-5 1996 Phorbol myristate acetate (PMA) induced macrophage-like differentiation and up-regulated the gamma c chain mRNA expression in THP-1 cells. Tetradecanoylphorbol Acetate 27-30 GLI family zinc finger 2 Homo sapiens 126-131 8723471-6 1996 Untreated THP-1 and phorbol myristate acetate-differentiated THP-1 were permissive for infection and multiplication of intracellular L. monocytogenes Hly+ (virulent variant). Tetradecanoylphorbol Acetate 20-45 GLI family zinc finger 2 Homo sapiens 61-66 8758495-4 1996 THP-1 cells were cultivated with a phorbol 12-myristate 13-acetate (PMA) for 24h prior to the infection. Tetradecanoylphorbol Acetate 35-66 GLI family zinc finger 2 Homo sapiens 0-5 8758495-4 1996 THP-1 cells were cultivated with a phorbol 12-myristate 13-acetate (PMA) for 24h prior to the infection. Tetradecanoylphorbol Acetate 68-71 GLI family zinc finger 2 Homo sapiens 0-5 8613704-1 1996 Human THP-1 leukemia cells differentiate along the monocytic lineage following exposure to phorbol-12-myristate-13-acetate (PMA) or 1,25-dihydroxyvitamin D3 (VD3). Tetradecanoylphorbol Acetate 91-122 GLI family zinc finger 2 Homo sapiens 6-11 8753812-1 1996 The human monocytic leukemic cell line, THP-1, which differentiates toward macrophages in response to phorbol 12-myristate 13-acetate (PMA) was investigated for its ability to produce granulocyte colony-stimulating factor (G-CSF). Tetradecanoylphorbol Acetate 102-133 GLI family zinc finger 2 Homo sapiens 40-45 8753812-1 1996 The human monocytic leukemic cell line, THP-1, which differentiates toward macrophages in response to phorbol 12-myristate 13-acetate (PMA) was investigated for its ability to produce granulocyte colony-stimulating factor (G-CSF). Tetradecanoylphorbol Acetate 135-138 GLI family zinc finger 2 Homo sapiens 40-45 8613704-1 1996 Human THP-1 leukemia cells differentiate along the monocytic lineage following exposure to phorbol-12-myristate-13-acetate (PMA) or 1,25-dihydroxyvitamin D3 (VD3). Tetradecanoylphorbol Acetate 124-127 GLI family zinc finger 2 Homo sapiens 6-11 8631819-6 1996 Binding of aLDL to phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages was suppressed by TNF-alpha in a dose-dependent manner. Tetradecanoylphorbol Acetate 19-50 GLI family zinc finger 2 Homo sapiens 72-77 8631819-6 1996 Binding of aLDL to phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophages was suppressed by TNF-alpha in a dose-dependent manner. Tetradecanoylphorbol Acetate 52-55 GLI family zinc finger 2 Homo sapiens 72-77 8850300-2 1996 125I-Labeled LF (125I-LF) bound to THP-1 cells, and the binding increased markedly as the cells matured into macrophages (THP-1 macrophages) by stimulation with phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 161-192 GLI family zinc finger 2 Homo sapiens 122-127 8786703-4 1996 Phorbol 12-myristate 13-acetate (PMA) arrests the constitutive cycling of THP-1 and induces a phenotype that approaches normalcy. Tetradecanoylphorbol Acetate 0-31 GLI family zinc finger 2 Homo sapiens 74-79 8654390-2 1996 The human heme-oxygenase-1 gene is transcriptionally activated through the cis-regulatory element (MTE), GTCATATGAC (positions -156 to -147), during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of myelomonocytic cell lines, such as THP-1, to macrophages. Tetradecanoylphorbol Acetate 149-185 GLI family zinc finger 2 Homo sapiens 254-259 8654390-2 1996 The human heme-oxygenase-1 gene is transcriptionally activated through the cis-regulatory element (MTE), GTCATATGAC (positions -156 to -147), during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of myelomonocytic cell lines, such as THP-1, to macrophages. Tetradecanoylphorbol Acetate 187-190 GLI family zinc finger 2 Homo sapiens 254-259 8786703-4 1996 Phorbol 12-myristate 13-acetate (PMA) arrests the constitutive cycling of THP-1 and induces a phenotype that approaches normalcy. Tetradecanoylphorbol Acetate 33-36 GLI family zinc finger 2 Homo sapiens 74-79 7593234-0 1995 Effect of 1,25-dihydroxyvitamin D3 on induction of scavenger receptor and differentiation of 12-O-tetradecanoylphorbol-13-acetate-treated THP-1 human monocyte like cells. Tetradecanoylphorbol Acetate 93-129 GLI family zinc finger 2 Homo sapiens 138-143 7545622-1 1995 Aromatase cytochrome P450 mRNA and activity was strongly expressed in THP 1 myeloid leukaemia cells after treatment with phorbol-myristate-acetate (PMA) and dexamethasone, low level expression was caused by calcitriol. Tetradecanoylphorbol Acetate 121-146 GLI family zinc finger 2 Homo sapiens 70-75 7593234-7 1995 The mRNA of type I scavenger receptor was first detected in THP-1 cells 4 days after the treatment with TPA, the mRNA level increased up to 6 days, and then decreased. Tetradecanoylphorbol Acetate 104-107 GLI family zinc finger 2 Homo sapiens 60-65 7593234-10 1995 These findings suggest that 1,25(OH)2D3 exclusively decreases the expression of scavenger receptors in TPA-induced THP-1 macrophages without affecting the basic cellular functions as macrophages. Tetradecanoylphorbol Acetate 103-106 GLI family zinc finger 2 Homo sapiens 115-120 7760824-1 1995 Human myeloid leukemia cells, such as HL60, U937, and THP1 cells, undergo macrophage differentiation and growth arrest following treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 162-198 GLI family zinc finger 2 Homo sapiens 54-58 7760824-1 1995 Human myeloid leukemia cells, such as HL60, U937, and THP1 cells, undergo macrophage differentiation and growth arrest following treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 200-203 GLI family zinc finger 2 Homo sapiens 54-58 7760824-7 1995 Analysis of THP1 nuclear proteins revealed a 55-kDa protein that was induced by TPA and interacted with the cdc2 promoter in an R-box-dependent manner. Tetradecanoylphorbol Acetate 80-83 GLI family zinc finger 2 Homo sapiens 12-16 7545622-1 1995 Aromatase cytochrome P450 mRNA and activity was strongly expressed in THP 1 myeloid leukaemia cells after treatment with phorbol-myristate-acetate (PMA) and dexamethasone, low level expression was caused by calcitriol. Tetradecanoylphorbol Acetate 148-151 GLI family zinc finger 2 Homo sapiens 70-75 7890370-6 1995 THP-1 cells showed maximal activation by the LPS molecules after cell differentiation was induced by phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 101-132 GLI family zinc finger 2 Homo sapiens 0-5 7545349-6 1995 Finally, LPS-stimulated Raji and PMA-stimulated THP-1 human cell lines showed increased levels of the cannabinoid receptor mRNA. Tetradecanoylphorbol Acetate 33-36 GLI family zinc finger 2 Homo sapiens 48-53 7624733-1 1995 The human monocytic leukaemia cell line THP-1 was induced to differentiate to macrophage-like cells by the addition of phorbol myristoyl acetate (PMA). Tetradecanoylphorbol Acetate 146-149 GLI family zinc finger 2 Homo sapiens 40-45 8011674-3 1994 LPS-mediated PLD activation of THP-1 or U-937 was inhibited by staurosporine (2 microM) and by protein kinase C (PKC) down-regulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) suggesting a role for PKC. Tetradecanoylphorbol Acetate 139-175 GLI family zinc finger 2 Homo sapiens 31-36 7661690-2 1995 Treatment of phorbol 12-myristate 13-acetate (PMA) differentiated monocyte-like cells THP-1 or human fibroblasts MRC-5 with lectins specific for N-acetylneuraminic acid (NeuAc) blocked infection with HCMV. Tetradecanoylphorbol Acetate 13-44 GLI family zinc finger 2 Homo sapiens 86-91 7661690-2 1995 Treatment of phorbol 12-myristate 13-acetate (PMA) differentiated monocyte-like cells THP-1 or human fibroblasts MRC-5 with lectins specific for N-acetylneuraminic acid (NeuAc) blocked infection with HCMV. Tetradecanoylphorbol Acetate 46-49 GLI family zinc finger 2 Homo sapiens 86-91 7915087-4 1994 In THP-1 macrophages, histamine inhibited 4 beta-phorbol 12-myristate 13-acetate (PMA)-induced H2O2 formation via the activation of H2 receptors. Tetradecanoylphorbol Acetate 44-80 GLI family zinc finger 2 Homo sapiens 3-8 7915087-4 1994 In THP-1 macrophages, histamine inhibited 4 beta-phorbol 12-myristate 13-acetate (PMA)-induced H2O2 formation via the activation of H2 receptors. Tetradecanoylphorbol Acetate 82-85 GLI family zinc finger 2 Homo sapiens 3-8 7869830-2 1995 THP-1 cells were exposed to TPA for 48 or 96 hours to induce differentiation. Tetradecanoylphorbol Acetate 28-31 GLI family zinc finger 2 Homo sapiens 0-5 7720732-4 1994 U937 cells and other human myeloid leukemia cell lines (HL-60, THP-1) can be induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to differentiate along the monocytic pathway. Tetradecanoylphorbol Acetate 106-142 GLI family zinc finger 2 Homo sapiens 63-68 7720732-4 1994 U937 cells and other human myeloid leukemia cell lines (HL-60, THP-1) can be induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to differentiate along the monocytic pathway. Tetradecanoylphorbol Acetate 144-147 GLI family zinc finger 2 Homo sapiens 63-68 7720732-6 1994 Thus, the presence of leukocyte integrins including CD11 and CD18, which are significantly induced during TPA-induced differentiation of HL-60, U937 and THP-1 cells, remained nearly unchanged at low levels in both TUR and TPA-treated TUR cells. Tetradecanoylphorbol Acetate 106-109 GLI family zinc finger 2 Homo sapiens 153-158 8011674-3 1994 LPS-mediated PLD activation of THP-1 or U-937 was inhibited by staurosporine (2 microM) and by protein kinase C (PKC) down-regulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) suggesting a role for PKC. Tetradecanoylphorbol Acetate 177-180 GLI family zinc finger 2 Homo sapiens 31-36 8119777-8 1994 The expression of NCA-50/90 by U-937 and THP-1 was down-regulated at both the protein and mRNA levels during cell differentiation from monoblastoid to monocyte/macrophage-like cells induced by stimulation with phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 210-241 GLI family zinc finger 2 Homo sapiens 41-46 7925881-4 1994 Of the stimuli used (phorbol myristate acetate, retinoic acid, calcitriol), only calcitriol can induce differentiation of THP-1 cells, as assessed by CD14 expression. Tetradecanoylphorbol Acetate 21-46 GLI family zinc finger 2 Homo sapiens 122-127 8247003-1 1993 The human monocytic leukemia cell line THP-1 differentiates into macrophage-like cells when treated with a variety of agents, including 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 136-172 GLI family zinc finger 2 Homo sapiens 39-44 7509804-4 1994 With THP-1 cells, PMA also induced the production of 92-kDa gelatinase fully, but unlike U937 cells, the combination of PMA and 1,25-(OH)2D3 was required for substantial interstitial collagenase biosynthesis. Tetradecanoylphorbol Acetate 18-21 GLI family zinc finger 2 Homo sapiens 5-10 8247003-1 1993 The human monocytic leukemia cell line THP-1 differentiates into macrophage-like cells when treated with a variety of agents, including 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 174-177 GLI family zinc finger 2 Homo sapiens 39-44 8228252-0 1993 Mechanism of release of soluble forms of tumor necrosis factor/lymphotoxin receptors by phorbol myristate acetate-stimulated human THP-1 cells in vitro. Tetradecanoylphorbol Acetate 88-113 GLI family zinc finger 2 Homo sapiens 131-136 1464736-9 1992 In THP-1 cells, TPA also induced a new, faster-migrating NF kappa B species not induced in monocytes. Tetradecanoylphorbol Acetate 16-19 GLI family zinc finger 2 Homo sapiens 3-8 8328965-4 1993 Treatment of THP-1 cells for 1-72 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) led to a stable enzyme activation, which was also found after partial purification of PLA2 from PMA-stimulated THP-1 cells. Tetradecanoylphorbol Acetate 59-90 GLI family zinc finger 2 Homo sapiens 13-18 8328965-4 1993 Treatment of THP-1 cells for 1-72 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) led to a stable enzyme activation, which was also found after partial purification of PLA2 from PMA-stimulated THP-1 cells. Tetradecanoylphorbol Acetate 59-90 GLI family zinc finger 2 Homo sapiens 208-213 8328965-4 1993 Treatment of THP-1 cells for 1-72 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) led to a stable enzyme activation, which was also found after partial purification of PLA2 from PMA-stimulated THP-1 cells. Tetradecanoylphorbol Acetate 92-95 GLI family zinc finger 2 Homo sapiens 13-18 8328965-4 1993 Treatment of THP-1 cells for 1-72 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) led to a stable enzyme activation, which was also found after partial purification of PLA2 from PMA-stimulated THP-1 cells. Tetradecanoylphorbol Acetate 92-95 GLI family zinc finger 2 Homo sapiens 208-213 8386622-2 1993 We have previously reported that a structural analog of cAMP (dibutyryl cAMP, Bt2cAMP) or agents elevating the endogenous cAMP levels strongly enhanced the PMA-induced interleukin-1 beta(IL-1 beta)-gene expression in human myeloid leukemia cells (THP-1, HL-60). Tetradecanoylphorbol Acetate 156-159 GLI family zinc finger 2 Homo sapiens 247-252 8396466-0 1993 Phorbol myristate acetate-differentiated THP-1 cells display increased levels of MHC class I and class II mRNA and interferon-gamma-inducible tumoricidal activity. Tetradecanoylphorbol Acetate 0-25 GLI family zinc finger 2 Homo sapiens 41-46 8396466-1 1993 The protein kinase C activators phorbol 12-myristate 13-acetate (PMA) and mezerein induce differentiation of human monocytic leukemia (THP-1) cells along the monocyte/macrophage pathway of development. Tetradecanoylphorbol Acetate 32-63 GLI family zinc finger 2 Homo sapiens 135-140 8396466-1 1993 The protein kinase C activators phorbol 12-myristate 13-acetate (PMA) and mezerein induce differentiation of human monocytic leukemia (THP-1) cells along the monocyte/macrophage pathway of development. Tetradecanoylphorbol Acetate 65-68 GLI family zinc finger 2 Homo sapiens 135-140 8134164-7 1993 Compared with another human monocytic leukemia cell line, THP-1, KP-1 expressed scavenger receptor and accumulated cholesterol ester more rapidly in the presence of 12-o-tetradecanoyl phorbol-13-acetate and acetylated LDL. Tetradecanoylphorbol Acetate 165-202 GLI family zinc finger 2 Homo sapiens 58-63 8460491-2 1993 Both infected cells (THP-1/HIV-1IIIB) growing in suspension and uninfected, phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells, which are adherent, showed ultrastructural characteristics of differentiated cells. Tetradecanoylphorbol Acetate 76-107 GLI family zinc finger 2 Homo sapiens 122-127 8460491-2 1993 Both infected cells (THP-1/HIV-1IIIB) growing in suspension and uninfected, phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells, which are adherent, showed ultrastructural characteristics of differentiated cells. Tetradecanoylphorbol Acetate 109-112 GLI family zinc finger 2 Homo sapiens 122-127 1518836-2 1992 In the present studies, THP-1 human monocytic leukemia cells were used to investigate mechanisms responsible for expression of the AcLDL receptor gene after treatment with phorbol 12-myristate 13-acetate (TPA). Tetradecanoylphorbol Acetate 172-203 GLI family zinc finger 2 Homo sapiens 24-29 1417981-1 1992 The treatment of human myeloid leukemia cells (HL-60, U-937, THP-1) with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with growth arrest and appearance of a differentiated monocytic phenotype. Tetradecanoylphorbol Acetate 73-109 GLI family zinc finger 2 Homo sapiens 61-66 1417981-1 1992 The treatment of human myeloid leukemia cells (HL-60, U-937, THP-1) with 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with growth arrest and appearance of a differentiated monocytic phenotype. Tetradecanoylphorbol Acetate 111-114 GLI family zinc finger 2 Homo sapiens 61-66 1518836-2 1992 In the present studies, THP-1 human monocytic leukemia cells were used to investigate mechanisms responsible for expression of the AcLDL receptor gene after treatment with phorbol 12-myristate 13-acetate (TPA). Tetradecanoylphorbol Acetate 205-208 GLI family zinc finger 2 Homo sapiens 24-29 1532844-0 1992 Changes in IgG Fc receptor expression induced by phorbol 12-myristate 13-acetate treatment of THP-1 monocytic leukemia cells. Tetradecanoylphorbol Acetate 49-80 GLI family zinc finger 2 Homo sapiens 94-99 1493432-1 1992 Previous studies showed that the human monocytic leukemia cell line THP-1 can be induced to undergo monocytic differentiation by tumor promoting phorbol esters (TPA), suggesting that protein kinase C (PK-C), the primary binding site of TPA, may play a role in the control of monocytic differentiation: The effect of exogenous phospholipase C (PLC) on THP-1 cells was investigated. Tetradecanoylphorbol Acetate 161-164 GLI family zinc finger 2 Homo sapiens 68-73 1493432-1 1992 Previous studies showed that the human monocytic leukemia cell line THP-1 can be induced to undergo monocytic differentiation by tumor promoting phorbol esters (TPA), suggesting that protein kinase C (PK-C), the primary binding site of TPA, may play a role in the control of monocytic differentiation: The effect of exogenous phospholipase C (PLC) on THP-1 cells was investigated. Tetradecanoylphorbol Acetate 161-164 GLI family zinc finger 2 Homo sapiens 351-356 1493432-1 1992 Previous studies showed that the human monocytic leukemia cell line THP-1 can be induced to undergo monocytic differentiation by tumor promoting phorbol esters (TPA), suggesting that protein kinase C (PK-C), the primary binding site of TPA, may play a role in the control of monocytic differentiation: The effect of exogenous phospholipase C (PLC) on THP-1 cells was investigated. Tetradecanoylphorbol Acetate 236-239 GLI family zinc finger 2 Homo sapiens 68-73 1644056-1 1992 Human myeloid leukemia cells (i.e., HL-60, U937, THP-1) which are induced to differentiate along the monocytic pathway by 12-O-tetradecanoylphorbol-13-acetate (TPA), revert back to the undifferentiated phenotype after 3 to 4 weeks. Tetradecanoylphorbol Acetate 122-158 GLI family zinc finger 2 Homo sapiens 49-54 1644056-1 1992 Human myeloid leukemia cells (i.e., HL-60, U937, THP-1) which are induced to differentiate along the monocytic pathway by 12-O-tetradecanoylphorbol-13-acetate (TPA), revert back to the undifferentiated phenotype after 3 to 4 weeks. Tetradecanoylphorbol Acetate 160-163 GLI family zinc finger 2 Homo sapiens 49-54 1531783-1 1992 Treatment of human myeloid leukemia cells (HL-60, U-937, THP-1) with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with differentiation along the monocytic lineage. Tetradecanoylphorbol Acetate 87-123 GLI family zinc finger 2 Homo sapiens 57-62 1531783-1 1992 Treatment of human myeloid leukemia cells (HL-60, U-937, THP-1) with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) is associated with differentiation along the monocytic lineage. Tetradecanoylphorbol Acetate 125-128 GLI family zinc finger 2 Homo sapiens 57-62 1371989-4 1992 Human myelomonocytic leukemia THP-1 cells were induced to differentiate into macrophage-like cells by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 117-153 GLI family zinc finger 2 Homo sapiens 30-35 1371989-4 1992 Human myelomonocytic leukemia THP-1 cells were induced to differentiate into macrophage-like cells by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 155-158 GLI family zinc finger 2 Homo sapiens 30-35 1532844-1 1992 We studied changes in the three types of Fc gamma receptor (FcR) on the THP-1 human monocytic leukemia cells, after incubation with the phorbol ester, PMA, which has been shown to alter the expression of several genes in these cells. Tetradecanoylphorbol Acetate 151-154 GLI family zinc finger 2 Homo sapiens 72-77 1742485-3 1991 Upon differentiation induced by phorbol ester (phorbol 12-myristate 13-acetate [PMA]), metabolites via the COX pathway were increased by 100-fold in ML-1 and THP-1 cells, while the LOX products remained barely detectable. Tetradecanoylphorbol Acetate 47-78 GLI family zinc finger 2 Homo sapiens 158-163 1742485-3 1991 Upon differentiation induced by phorbol ester (phorbol 12-myristate 13-acetate [PMA]), metabolites via the COX pathway were increased by 100-fold in ML-1 and THP-1 cells, while the LOX products remained barely detectable. Tetradecanoylphorbol Acetate 80-83 GLI family zinc finger 2 Homo sapiens 158-163 2007095-6 1991 Similar increases in jun-B transcripts were detectable in TPA-treated THP-1 and U-937 myeloid leukemia cells, although expression of this gene was transient in the more differentiated THP-1 cells. Tetradecanoylphorbol Acetate 58-61 GLI family zinc finger 2 Homo sapiens 70-75 1797949-1 1991 A human monocytic cell line, THP-1, stimulated with 40 nM phorbol myristate acetate (PMA), differentiated to macrophage-like cells, and exhibited increased expression and release of interleukin-1 beta and expression of acetylated low density lipoprotein (ac-LDL) receptors. Tetradecanoylphorbol Acetate 58-83 GLI family zinc finger 2 Homo sapiens 29-34 1797949-1 1991 A human monocytic cell line, THP-1, stimulated with 40 nM phorbol myristate acetate (PMA), differentiated to macrophage-like cells, and exhibited increased expression and release of interleukin-1 beta and expression of acetylated low density lipoprotein (ac-LDL) receptors. Tetradecanoylphorbol Acetate 85-88 GLI family zinc finger 2 Homo sapiens 29-34 1986775-9 1991 12-O-tetradecanoylphorbol-13-acetate (TPA) suppresses ERP secretion by THP-1 cells, but it does not modify secretion in macrophages. Tetradecanoylphorbol Acetate 0-36 GLI family zinc finger 2 Homo sapiens 71-76 1986775-9 1991 12-O-tetradecanoylphorbol-13-acetate (TPA) suppresses ERP secretion by THP-1 cells, but it does not modify secretion in macrophages. Tetradecanoylphorbol Acetate 38-41 GLI family zinc finger 2 Homo sapiens 71-76 1905924-6 1991 Stimulation of THP1 cells for 2-4 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) activated cytosolic and membrane-bound phospholipase A2. Tetradecanoylphorbol Acetate 59-90 GLI family zinc finger 2 Homo sapiens 15-19 1905924-6 1991 Stimulation of THP1 cells for 2-4 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) activated cytosolic and membrane-bound phospholipase A2. Tetradecanoylphorbol Acetate 92-95 GLI family zinc finger 2 Homo sapiens 15-19 2365815-1 1990 The phorbol myristate acetate (PMA)-differentiated myelomonocytic cell line, THP-1, and human alveolar macrophages contain the cysteine proteinase cathepsin L. Tetradecanoylphorbol Acetate 4-29 GLI family zinc finger 2 Homo sapiens 77-82 2365815-1 1990 The phorbol myristate acetate (PMA)-differentiated myelomonocytic cell line, THP-1, and human alveolar macrophages contain the cysteine proteinase cathepsin L. Tetradecanoylphorbol Acetate 31-34 GLI family zinc finger 2 Homo sapiens 77-82 2307845-9 1990 THP-1 cells express low levels of an abnormally sized mRNA for PAI-2 and demonstrate a regulatory defect whereby steady state levels of PAI-2 mRNA are markedly reduced upon stimulation with PMA or LPS. Tetradecanoylphorbol Acetate 190-193 GLI family zinc finger 2 Homo sapiens 0-5 2140592-0 1990 Inhibition of TPA-induced monocytic differentiation in THP-1 human monocytic leukemic cells by staurosporine, a potent protein kinase C inhibitor. Tetradecanoylphorbol Acetate 14-17 GLI family zinc finger 2 Homo sapiens 55-60 11222479-3 2001 This study investigates the effect of interferon (IFN)-gamma on VLDL receptor expression in phorbol-12-myristate-13-acetate (PMA)-treated THP-1, HL-60 macrophages, and human monocyte-derived macrophages. Tetradecanoylphorbol Acetate 92-123 GLI family zinc finger 2 Homo sapiens 138-143 11222479-3 2001 This study investigates the effect of interferon (IFN)-gamma on VLDL receptor expression in phorbol-12-myristate-13-acetate (PMA)-treated THP-1, HL-60 macrophages, and human monocyte-derived macrophages. Tetradecanoylphorbol Acetate 125-128 GLI family zinc finger 2 Homo sapiens 138-143 1696041-3 1990 In this study the human myelomonoblast line THP-1 has been used to study monocytic differentiation in response to various cytokines and the phorbolester TPA. Tetradecanoylphorbol Acetate 153-156 GLI family zinc finger 2 Homo sapiens 44-49 1696041-4 1990 After treatment of THP-1 cells with Tumor Necrosis Factor (TNF)-alpha, Interleukin (IL-6) and TPA the cells became adherent, lost their division potential and expressed new surface structures associated with monocytic differentiation. Tetradecanoylphorbol Acetate 94-97 GLI family zinc finger 2 Homo sapiens 19-24 2140592-1 1990 THP-1 is a factor-indepencent, monocytic leukemia cell line which differentiates into adherent macrophages upon treatment with 12-O-tetra-decanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 166-169 GLI family zinc finger 2 Homo sapiens 0-5 2140592-3 1990 Northern blot analysis showed that the c-FMS mRNA levels in THP-1 cells was greatly enhanced during TPA-induced monocytic differentiation. Tetradecanoylphorbol Acetate 100-103 GLI family zinc finger 2 Homo sapiens 60-65 2140592-5 1990 The inducing activity associated with TPA was completely abrogated when THP-1 cells were pretreated with staurosporine, a potent protein kinase C (PK-C) inhibitor. Tetradecanoylphorbol Acetate 38-41 GLI family zinc finger 2 Homo sapiens 72-77 11222479-7 2001 In THP-1 macrophages, VLDL receptor protein expression decreased at 2 days after PMA treatment but increased at 3 days and increased up to 5 days. Tetradecanoylphorbol Acetate 81-84 GLI family zinc finger 2 Homo sapiens 3-8