PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7683406-1 1993 CD43, the major sialoglycoprotein of human leukocytes, whose expression is defective in patients with the Wiskott-Aldrich syndrome, was down-regulated by phorbol 12-myristate 13-acetate (PMA) on granulocytes but not on lymphocytes. Tetradecanoylphorbol Acetate 154-185 sialophorin Homo sapiens 0-4 2531463-5 1989 We show that CD43 was rapidly superphosphorylated (within minutes) on serine residues following addition of phorbol ester (PMA) to peripheral blood lymphocytes. Tetradecanoylphorbol Acetate 123-126 sialophorin Homo sapiens 13-17 2785706-3 1989 In the presence of TPA or antibodies to CDw40, the proportions of CD43+ cells drastically increased. Tetradecanoylphorbol Acetate 19-22 sialophorin Homo sapiens 66-70 2785706-6 1989 Tonsillar populations depleted of CD43+ B cells responded with lower proliferation to TPA alone or to TPA and B1B6 or anti-CDw40 antibodies. Tetradecanoylphorbol Acetate 86-89 sialophorin Homo sapiens 34-38 2785706-6 1989 Tonsillar populations depleted of CD43+ B cells responded with lower proliferation to TPA alone or to TPA and B1B6 or anti-CDw40 antibodies. Tetradecanoylphorbol Acetate 102-105 sialophorin Homo sapiens 34-38 25436216-12 2014 CONCLUSION: We found that the disparities observed in tPA use were attenuated after adjustment for time from LSN-to-ED arrival, suggesting an area for future intervention. Tetradecanoylphorbol Acetate 54-57 sialophorin Homo sapiens 109-112 7925647-7 1994 Labeling of cell surface carbohydrates with [3H]-glucosamine followed by treatment with TPA revealed that O-glycosylated glycoproteins including CD43 were released from the cell surface during this treatment. Tetradecanoylphorbol Acetate 88-91 sialophorin Homo sapiens 145-149 7835929-5 1994 Expression of CD43 on HMC-1 was down-regulated after stimulation with phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 70-95 sialophorin Homo sapiens 14-18 7835929-5 1994 Expression of CD43 on HMC-1 was down-regulated after stimulation with phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 97-100 sialophorin Homo sapiens 14-18 2785706-10 1989 Furthermore, CD43+ B cells are included in the population which responds to signals delivered by TPA, anti-CD43 or anti-CDw40 antibodies, and the proliferation of this population is not merely due to an expansion of the small population of CD43+ cells present among these cells. Tetradecanoylphorbol Acetate 97-100 sialophorin Homo sapiens 13-17 9241533-1 1997 Leukosialin (CD43), the major sialoprotein on circulating leukocytes, has been previously described to be down-regulated on neutrophils following activation with phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 162-187 sialophorin Homo sapiens 13-17 9241533-1 1997 Leukosialin (CD43), the major sialoprotein on circulating leukocytes, has been previously described to be down-regulated on neutrophils following activation with phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 189-192 sialophorin Homo sapiens 13-17 9241533-7 1997 Inhibitors of serine proteases, like phenylmethylsulphonyl fluoride (PMSF), benzamidine and 3, 4-dichloroisocoumarin, blocked the PMA-mediated cleavage of CD43. Tetradecanoylphorbol Acetate 130-133 sialophorin Homo sapiens 155-159 7811990-5 1995 Based on densitometry of immune precipitates, CD43 levels were decreased 42% +/- 6% in neutrophils treated for 10 minutes with opsonized zymosan and decreased 70% +/- 3% in neutrophils treated with phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 198-229 sialophorin Homo sapiens 46-50 7811990-5 1995 Based on densitometry of immune precipitates, CD43 levels were decreased 42% +/- 6% in neutrophils treated for 10 minutes with opsonized zymosan and decreased 70% +/- 3% in neutrophils treated with phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 231-234 sialophorin Homo sapiens 46-50 7811990-6 1995 CD43 downregulation in response to opsonized zymosan, like PMA-induced CD43 downregulation, was insensitive to the serine protease inhibitor diisopropylfluorophosphate (DFP). Tetradecanoylphorbol Acetate 59-62 sialophorin Homo sapiens 0-4 7811990-6 1995 CD43 downregulation in response to opsonized zymosan, like PMA-induced CD43 downregulation, was insensitive to the serine protease inhibitor diisopropylfluorophosphate (DFP). Tetradecanoylphorbol Acetate 59-62 sialophorin Homo sapiens 71-75 7683406-1 1993 CD43, the major sialoglycoprotein of human leukocytes, whose expression is defective in patients with the Wiskott-Aldrich syndrome, was down-regulated by phorbol 12-myristate 13-acetate (PMA) on granulocytes but not on lymphocytes. Tetradecanoylphorbol Acetate 187-190 sialophorin Homo sapiens 0-4 7683406-6 1993 Importantly, PMA-induced down-regulation of CD43 on granulocytes was markedly blocked both by the metalloprotease inhibitor 1,10-phenanthroline and by the serine protease inhibitors N alpha-(p-tosyl)-L-lysine chloromethyl ketone and Pefabloc SC, which inhibit two different classes of proteases, thus indicating that the release is proteolytic. Tetradecanoylphorbol Acetate 13-16 sialophorin Homo sapiens 44-48 1358626-3 1992 As tested by immunofluorescence, neutrophil CD43 membrane expression was shown to decrease by up to 80% upon cell activation by phorbol myristate acetate (10 ng/ml) or by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP; 10(-6) M) in the presence of cytochalasin B. Tetradecanoylphorbol Acetate 128-153 sialophorin Homo sapiens 44-48 1594606-6 1992 The CD43 anti-adhesion effect was not overcome by treating cells with phorbol 12-myristate 13-acetate, a chemical that increases the binding avidity of leukocyte function-associated antigen 1 for intercellular adhesion molecule 1. Tetradecanoylphorbol Acetate 70-101 sialophorin Homo sapiens 4-8 1708162-4 1991 As expected, activation of protein kinase C by TPA increased both CD40 and CD43. Tetradecanoylphorbol Acetate 47-50 sialophorin Homo sapiens 75-79 1708162-6 1991 However, in the presence of TPA, ionomycin further up-regulated CD43 but not CD40. Tetradecanoylphorbol Acetate 28-31 sialophorin Homo sapiens 64-68 2137493-7 1990 The inhibition of CD43-mediated signaling by PMA was due, in part, to uncoupling of CD43 from the signal-transducing G protein. Tetradecanoylphorbol Acetate 45-48 sialophorin Homo sapiens 18-22 2137493-7 1990 The inhibition of CD43-mediated signaling by PMA was due, in part, to uncoupling of CD43 from the signal-transducing G protein. Tetradecanoylphorbol Acetate 45-48 sialophorin Homo sapiens 84-88 2137493-11 1990 Staurosporine, a potent inhibitor of PKC, abrogated the hyperphosphorylation of CD43 and normalized CD43-mediated signaling in PMA-treated cells. Tetradecanoylphorbol Acetate 127-130 sialophorin Homo sapiens 100-104