PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25297509-8	2014	Primary-cultured skin keratinocytes from CKO mice also showed reduced expression of these cytokines and weak activation of Rap1 compared with those from control mice after the TPA treatment.	Tetradecanoylphorbol Acetate	176-179	RAS-related protein 1a	Mus musculus	123-127	
11124936-5	2001	In 32D cells, Rap1 was also activated by phorbol 12-myristate 13-acetate and ionomycin, which also enhanced cell adhesion to fibronectin, whereas, an inhibitor of phospholipase C, inhibited both cytokine-induced activation of Rap1 and cell adhesion.	Tetradecanoylphorbol Acetate	41-72	RAS-related protein 1a	Mus musculus	14-18	
11124936-5	2001	In 32D cells, Rap1 was also activated by phorbol 12-myristate 13-acetate and ionomycin, which also enhanced cell adhesion to fibronectin, whereas, an inhibitor of phospholipase C, inhibited both cytokine-induced activation of Rap1 and cell adhesion.	Tetradecanoylphorbol Acetate	41-72	RAS-related protein 1a	Mus musculus	226-230	
18172297-8	2008	Experiments using small interfering RNA-mediated knockdown indicate that this activation is mediated by Rap1, which is activated by a TPA-responsive guanine nucleotide exchange factor RasGRP3.	Tetradecanoylphorbol Acetate	134-137	RAS-related protein 1a	Mus musculus	104-108	
18172297-9	2008	Moreover, TPA-induced activation of Rap1 and PLC epsilon is inhibited by a PKC inhibitor GF109203X, indicating a crucial role of PKC in signaling from TPA to PLC epsilon.	Tetradecanoylphorbol Acetate	10-13	RAS-related protein 1a	Mus musculus	36-40	
18172297-9	2008	Moreover, TPA-induced activation of Rap1 and PLC epsilon is inhibited by a PKC inhibitor GF109203X, indicating a crucial role of PKC in signaling from TPA to PLC epsilon.	Tetradecanoylphorbol Acetate	151-154	RAS-related protein 1a	Mus musculus	36-40