PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19420016-4 2009 PMA-induced cell invasion was blocked in the presence of a primary antibody of MMP-9, and KPS-A suppressed the increased expression and/or secretion of MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1. Tetradecanoylphorbol Acetate 0-3 TIMP metallopeptidase inhibitor 1 Homo sapiens 162-208 12882798-7 2003 12-O-tetradecanoyl-phorbol-13-acetate was effective in increasing the levels of proMMP-1, -3, and -9 and TIMP-1. Tetradecanoylphorbol Acetate 0-37 TIMP metallopeptidase inhibitor 1 Homo sapiens 105-111 15324351-8 2004 Tyrosine kinase inhibitor herbimycin A reduced MMP-1 production induced by PMA, whereas the p38 MAPK-inhibitor SB 203580 synergistically increased the stimulatory effect of PMA on both MMP-1 and TIMP-1 production. Tetradecanoylphorbol Acetate 173-176 TIMP metallopeptidase inhibitor 1 Homo sapiens 195-201 15252145-9 2004 Furthermore, nobiletin enhancement of TIMP-1 production in TPA-stimulated HT-1080 cells was found to be diminished by adding a JNK inhibitor, SP600125. Tetradecanoylphorbol Acetate 59-62 TIMP metallopeptidase inhibitor 1 Homo sapiens 38-44 15274349-5 2004 PMA also inhibited the nafoxidine-induced secretion of metalloproteinase-2 and tissue inhibitor of metalloproteinases-1 in HUVEC monolayers. Tetradecanoylphorbol Acetate 0-3 TIMP metallopeptidase inhibitor 1 Homo sapiens 55-119 12620479-7 2003 RESULT(S): Phorbol 12-myristate 13-acetate elicited an increase in MMP-9 and TIMP-1 secretion in both groups and apparently did not affect progesterone secretion. Tetradecanoylphorbol Acetate 11-42 TIMP metallopeptidase inhibitor 1 Homo sapiens 77-83 12454040-16 2002 TIMP-1 protein levels were increased 27% +/- 9.3% and 15% +/- 11% in the media of cells exposed for 24 hours to 100 nM LA and 100 nM PMA, respectively (n = 5). Tetradecanoylphorbol Acetate 133-136 TIMP metallopeptidase inhibitor 1 Homo sapiens 0-6 12134900-6 2002 In addition, PMA-induced downregulation of TIMP-1 and TIMP-2 secretion and upregulation of the membrane type I MMP, a major activator of MMP-2 on the cell surface, were reversed by SB203580 in these cells; the PMA-induced increase of invasion in vitro decreased when SB203580 was added to the top compartment of a modified Boyden chamber; and the inhibitor also reduced the MMP secretion and PMA-induced in vitro invasion in various glioma cell lines. Tetradecanoylphorbol Acetate 13-16 TIMP metallopeptidase inhibitor 1 Homo sapiens 43-49 10936484-8 2000 AGN 4204 increased PMA-induced tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) expression, whereas all PPAR ligands showed no effect. Tetradecanoylphorbol Acetate 19-22 TIMP metallopeptidase inhibitor 1 Homo sapiens 31-78 12058964-4 2002 TPA stimulated MMP-1, -9 and TIMP-1 mRNA expression in both cell lines. Tetradecanoylphorbol Acetate 0-3 TIMP metallopeptidase inhibitor 1 Homo sapiens 29-35 10936484-8 2000 AGN 4204 increased PMA-induced tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) expression, whereas all PPAR ligands showed no effect. Tetradecanoylphorbol Acetate 19-22 TIMP metallopeptidase inhibitor 1 Homo sapiens 80-86 10487706-7 1999 In benign cells, however, TPA induced a small, though significant, increase in TIMP-1. Tetradecanoylphorbol Acetate 26-29 TIMP metallopeptidase inhibitor 1 Homo sapiens 79-85 10487706-8 1999 The MMP-1 stimulation by EGF and lack of TPA-induced rise in TIMP-1 in malignant cells, in sharp contrast to the effects obtained in benign thyrocytes, seems to indicate that the MMP: TIMP balance favors a more extensive extracellular matrix protein breakdown by malignant thyrocytes, as expected of cells exhibiting invasive capacity. Tetradecanoylphorbol Acetate 41-44 TIMP metallopeptidase inhibitor 1 Homo sapiens 61-67 10487706-9 1999 TSH (10-500 microU/mL) failed to significantly influence basal MMP-1 or TIMP-1 mRNA levels, but it caused a dose-dependent inhibition in TPA- and EGF-induced MMP-1 mRNA in malignant cells, and TPA-stimulated MMP-1 and TIMP-1 in benign cells. Tetradecanoylphorbol Acetate 137-140 TIMP metallopeptidase inhibitor 1 Homo sapiens 218-224 8913498-1 1996 In this report, we have investigated the effect of interleukin 1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA), potent stimulators of proMMPs and TIMP-1 production, on the translation of proMMP-3 and TIMP-1 mRNAs. Tetradecanoylphorbol Acetate 88-124 TIMP metallopeptidase inhibitor 1 Homo sapiens 166-172 10329260-5 1999 Phorbol myristate acetate, known to induce protease activity in other endothelial cell populations, stimulated MMP1, MMP9, and TIMP1 secretion in both NDEC and PEDEC. Tetradecanoylphorbol Acetate 0-25 TIMP metallopeptidase inhibitor 1 Homo sapiens 127-132 9665201-5 1998 Whereas 12-O-tetradecanoylphorbol-13 acetate (TPA) increased both MMP-9 and TIMP-1 mRNA levels, tumor necrosis factor-alpha (TNF-alpha) stimulated only MMP-9 gene expression in a dose- and time-dependent manner. Tetradecanoylphorbol Acetate 8-44 TIMP metallopeptidase inhibitor 1 Homo sapiens 76-82 9665201-5 1998 Whereas 12-O-tetradecanoylphorbol-13 acetate (TPA) increased both MMP-9 and TIMP-1 mRNA levels, tumor necrosis factor-alpha (TNF-alpha) stimulated only MMP-9 gene expression in a dose- and time-dependent manner. Tetradecanoylphorbol Acetate 46-49 TIMP metallopeptidase inhibitor 1 Homo sapiens 76-82 9543636-5 1998 RESULTS: A phorbol mitogen (TPA), and TNF alpha and beta, interleukin-1 alpha and PDGF BB stimulate gelatinase B, stromelysin, interstitial collagenase and TIMP-1 expression, while having negligible effects on gelatinase A expression; TIMP-2 levels are reduced by TNF but not affected by the other treatments. Tetradecanoylphorbol Acetate 28-31 TIMP metallopeptidase inhibitor 1 Homo sapiens 156-162 9054554-1 1997 Upon exposure to 12-O-tetradecanoylphorbol 13-acetate (PMA), promonocyte-like U937 cells differentiate into macrophage-like cells and begin to express certain metalloproteinases and TIMP-1. Tetradecanoylphorbol Acetate 17-53 TIMP metallopeptidase inhibitor 1 Homo sapiens 182-188 9054554-1 1997 Upon exposure to 12-O-tetradecanoylphorbol 13-acetate (PMA), promonocyte-like U937 cells differentiate into macrophage-like cells and begin to express certain metalloproteinases and TIMP-1. Tetradecanoylphorbol Acetate 55-58 TIMP metallopeptidase inhibitor 1 Homo sapiens 182-188 9548562-10 1998 Ionomycin- and TPA-induced HB-EGF-AP secretion was not dependent on the presence of the proHB-EGF cytoplasmic domain and was specifically inhibited by the metalloproteinase inhibitors 1,10-phenanthroline and tissue inhibitor of metalloproteinase-1 (TIMP-1). Tetradecanoylphorbol Acetate 15-18 TIMP metallopeptidase inhibitor 1 Homo sapiens 208-247 9548562-10 1998 Ionomycin- and TPA-induced HB-EGF-AP secretion was not dependent on the presence of the proHB-EGF cytoplasmic domain and was specifically inhibited by the metalloproteinase inhibitors 1,10-phenanthroline and tissue inhibitor of metalloproteinase-1 (TIMP-1). Tetradecanoylphorbol Acetate 15-18 TIMP metallopeptidase inhibitor 1 Homo sapiens 249-255 9568638-6 1998 Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific. Tetradecanoylphorbol Acetate 15-51 TIMP metallopeptidase inhibitor 1 Homo sapiens 88-94 9568638-6 1998 Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific. Tetradecanoylphorbol Acetate 53-56 TIMP metallopeptidase inhibitor 1 Homo sapiens 88-94 9242444-5 1997 Surface biotinylation and immunoprecipitation with anti-MMP-9 antibodies revealed the presence of two MMP-9 forms (M(r) 92,000 and 85,000) on the surface of TPA-treated MCF10A cells, whereas in the media, only the M(r) 92,000 form was detected, mostly in complex with TIMP-1, a specific MMP-9 inhibitor. Tetradecanoylphorbol Acetate 157-160 TIMP metallopeptidase inhibitor 1 Homo sapiens 268-274 9242444-10 1997 These studies demonstrate a specific cell surface association of MMP-9 in response to TPA that may help to localize TIMP-1-free enzyme on the surface of breast epithelial cells. Tetradecanoylphorbol Acetate 86-89 TIMP metallopeptidase inhibitor 1 Homo sapiens 116-122 8913498-1 1996 In this report, we have investigated the effect of interleukin 1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA), potent stimulators of proMMPs and TIMP-1 production, on the translation of proMMP-3 and TIMP-1 mRNAs. Tetradecanoylphorbol Acetate 88-124 TIMP metallopeptidase inhibitor 1 Homo sapiens 220-226 8913498-1 1996 In this report, we have investigated the effect of interleukin 1 alpha (IL-1 alpha) and 12-O-tetradecanoylphorbol 13-acetate (TPA), potent stimulators of proMMPs and TIMP-1 production, on the translation of proMMP-3 and TIMP-1 mRNAs. Tetradecanoylphorbol Acetate 126-129 TIMP metallopeptidase inhibitor 1 Homo sapiens 166-172 8913498-2 1996 When human uterine cervical fibroblasts were treated with IL-1 alpha or TPA for 2h, their translations were not augmented, whereas the steady-state levels of proMMP-3 and TIMP-1 mRNAs in the cells treated with these stimuli for 24 h were increased 13.3- and 1.3-fold by IL-1 alpha and 52.5- and 5.7-fold by TPA, respectively. Tetradecanoylphorbol Acetate 72-75 TIMP metallopeptidase inhibitor 1 Homo sapiens 171-177 8878412-3 1996 Treatment of MCF-7 cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (100 nM) was associated with a high expression of MMP-1 mRNA, as well as an induction of the level of TIMP-1 mRNA (5- to 10-fold). Tetradecanoylphorbol Acetate 48-84 TIMP metallopeptidase inhibitor 1 Homo sapiens 193-199 8878412-3 1996 Treatment of MCF-7 cells with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) (100 nM) was associated with a high expression of MMP-1 mRNA, as well as an induction of the level of TIMP-1 mRNA (5- to 10-fold). Tetradecanoylphorbol Acetate 86-89 TIMP metallopeptidase inhibitor 1 Homo sapiens 193-199 8613475-4 1996 TPA treatment of HT1080 cells induced the expression of interstitial collagenase (MMP-1) and increased the expression of gelatinase B (MMP-9), tissue inhibitor of metalloproteinases-1 (TIMP-1), and MT-MMP, a membrane-bound activator of progelatinase A (proMMP-2), while MMP-2 and TIMP-2 expression were decreased. Tetradecanoylphorbol Acetate 0-3 TIMP metallopeptidase inhibitor 1 Homo sapiens 143-183 8613475-4 1996 TPA treatment of HT1080 cells induced the expression of interstitial collagenase (MMP-1) and increased the expression of gelatinase B (MMP-9), tissue inhibitor of metalloproteinases-1 (TIMP-1), and MT-MMP, a membrane-bound activator of progelatinase A (proMMP-2), while MMP-2 and TIMP-2 expression were decreased. Tetradecanoylphorbol Acetate 0-3 TIMP metallopeptidase inhibitor 1 Homo sapiens 185-191 8706790-4 1996 In both young and old cells, phorbol myristoyl-13 acetate (PMA) induced the expression of transcripts of collagenase, stromelysin-1, gelatinase-B, TIMP-1, and TIMP-3. Tetradecanoylphorbol Acetate 59-62 TIMP metallopeptidase inhibitor 1 Homo sapiens 147-153 7615646-8 1995 The phorbol ester, PMA, up-regulated considerably the mRNA expression of TIMP-1 but had no effect on protein production. Tetradecanoylphorbol Acetate 19-22 TIMP metallopeptidase inhibitor 1 Homo sapiens 73-79 7543547-6 1995 PMA stimulated the production of collagenase, stromelysin, 92-kDa gelatinase, and TIMP-1 in both endothelial cell types. Tetradecanoylphorbol Acetate 0-3 TIMP metallopeptidase inhibitor 1 Homo sapiens 82-88 7616276-7 1995 Interstitial collagenase, gelatinase B, stromelysin, and TIMP-1 genes were upregulated in many cell lines by phorbol-12-myristate-13-acetate (PMA) and in some cell lines by epidermal growth factor, tumor necrosis factor-alpha, or interleukin-1 beta. Tetradecanoylphorbol Acetate 109-140 TIMP metallopeptidase inhibitor 1 Homo sapiens 57-63 7616276-7 1995 Interstitial collagenase, gelatinase B, stromelysin, and TIMP-1 genes were upregulated in many cell lines by phorbol-12-myristate-13-acetate (PMA) and in some cell lines by epidermal growth factor, tumor necrosis factor-alpha, or interleukin-1 beta. Tetradecanoylphorbol Acetate 142-145 TIMP metallopeptidase inhibitor 1 Homo sapiens 57-63 7512058-7 1994 Morphological examination of control, PMA-treated HUVECs, as well as PMA-treated HUVECs receiving TIMP or BB-94, revealed that MMP inhibition resulted in a block to invasion and tubule formation within the collagen gels. Tetradecanoylphorbol Acetate 69-72 TIMP metallopeptidase inhibitor 1 Homo sapiens 98-102 8268245-2 1993 IL-1 and a protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) augmented the production of proMMP-1 (interstitial procollagenase), proMMP-3 (prostromelysin-1) and TIMP-1, but their effects were inhibited by the protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and staurosporine in a dose-dependent manner. Tetradecanoylphorbol Acetate 39-75 TIMP metallopeptidase inhibitor 1 Homo sapiens 182-188 8268245-2 1993 IL-1 and a protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) augmented the production of proMMP-1 (interstitial procollagenase), proMMP-3 (prostromelysin-1) and TIMP-1, but their effects were inhibited by the protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and staurosporine in a dose-dependent manner. Tetradecanoylphorbol Acetate 77-80 TIMP metallopeptidase inhibitor 1 Homo sapiens 182-188 8253535-6 1993 Addition of TIMP (tissue inhibitors of metalloproteinase)-I inhibited TPA-enhanced invasion of Matrigel by only up to 13%. Tetradecanoylphorbol Acetate 70-73 TIMP metallopeptidase inhibitor 1 Homo sapiens 12-16 8253535-6 1993 Addition of TIMP (tissue inhibitors of metalloproteinase)-I inhibited TPA-enhanced invasion of Matrigel by only up to 13%. Tetradecanoylphorbol Acetate 70-73 TIMP metallopeptidase inhibitor 1 Homo sapiens 18-56 8476858-2 1993 Our results show that differentiation of U937 cells with exposure to 12-O-tetradecanoylphorbol 13-acetate (TPA) induces a temporally delayed (16-24 h) but marked increase in the biosynthesis and secretion of interstitial collagenase and TIMP. Tetradecanoylphorbol Acetate 69-105 TIMP metallopeptidase inhibitor 1 Homo sapiens 237-241 8253876-8 1993 These data demonstrate that TPA-stimulated lymphoid cells adhere to type IV collagen and subsequently synthesize and secrete gelatinase B and TIMP-1. Tetradecanoylphorbol Acetate 28-31 TIMP metallopeptidase inhibitor 1 Homo sapiens 142-148 8476858-2 1993 Our results show that differentiation of U937 cells with exposure to 12-O-tetradecanoylphorbol 13-acetate (TPA) induces a temporally delayed (16-24 h) but marked increase in the biosynthesis and secretion of interstitial collagenase and TIMP. Tetradecanoylphorbol Acetate 107-110 TIMP metallopeptidase inhibitor 1 Homo sapiens 237-241 8476858-7 1993 However, TPA exposure markedly prolonged the half-life of TIMP mRNA from 4 h to > 20 h. While cycloheximide treatment completely blocked TPA-mediated induction of collagenase mRNA, it only marginally interfered with simultaneously induced TIMP mRNA levels. Tetradecanoylphorbol Acetate 9-12 TIMP metallopeptidase inhibitor 1 Homo sapiens 58-62 8476858-7 1993 However, TPA exposure markedly prolonged the half-life of TIMP mRNA from 4 h to > 20 h. While cycloheximide treatment completely blocked TPA-mediated induction of collagenase mRNA, it only marginally interfered with simultaneously induced TIMP mRNA levels. Tetradecanoylphorbol Acetate 9-12 TIMP metallopeptidase inhibitor 1 Homo sapiens 242-246 8476858-7 1993 However, TPA exposure markedly prolonged the half-life of TIMP mRNA from 4 h to > 20 h. While cycloheximide treatment completely blocked TPA-mediated induction of collagenase mRNA, it only marginally interfered with simultaneously induced TIMP mRNA levels. Tetradecanoylphorbol Acetate 140-143 TIMP metallopeptidase inhibitor 1 Homo sapiens 58-62 8476858-7 1993 However, TPA exposure markedly prolonged the half-life of TIMP mRNA from 4 h to > 20 h. While cycloheximide treatment completely blocked TPA-mediated induction of collagenase mRNA, it only marginally interfered with simultaneously induced TIMP mRNA levels. Tetradecanoylphorbol Acetate 140-143 TIMP metallopeptidase inhibitor 1 Homo sapiens 242-246 2176183-5 1990 The phorbol mitogen, 12-tetradecanoylphorbol-13-acetate, differentially increases the levels of these metalloproteinases and TIMP found in retinal pigment epithelium culture medium with stromelysin and the 92-kD type IV collagenase responding most strongly and TIMP actually decreasing in certain cases. Tetradecanoylphorbol Acetate 21-55 TIMP metallopeptidase inhibitor 1 Homo sapiens 125-129 1284126-4 1992 In contrast, MMP-3, MMP-9 and TIMP-1 activities were markedly stimulated by TPA in most of the tumor cell lines and human umbilical vein endothelial cells (HUVEC), whereas the fibroblast lines were minimally stimulated or unresponsive to TPA. Tetradecanoylphorbol Acetate 76-79 TIMP metallopeptidase inhibitor 1 Homo sapiens 30-36 1284126-11 1992 TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC). Tetradecanoylphorbol Acetate 0-3 TIMP metallopeptidase inhibitor 1 Homo sapiens 38-44 2174435-8 1990 In comparison, 12-O-tetradecanoylphorbol-13-acetate (50 ng/ml, 8 x 10(-8) M), which also stimulates collagenase expression strongly (greater than 30-fold), elevated TIMP protein and mRNA levels (2- and 3-fold, respectively) and did not affect MMP-2 expression. Tetradecanoylphorbol Acetate 15-51 TIMP metallopeptidase inhibitor 1 Homo sapiens 165-169 1330702-4 1992 We show at mRNA and protein levels that TIMP-1 is expressed in differentiated human hepatoma cells (HepG2) and that its synthesis is up-regulated by interleukin-6 (IL-6), transforming growth factor beta 1 and phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 209-240 TIMP metallopeptidase inhibitor 1 Homo sapiens 40-46 2176183-5 1990 The phorbol mitogen, 12-tetradecanoylphorbol-13-acetate, differentially increases the levels of these metalloproteinases and TIMP found in retinal pigment epithelium culture medium with stromelysin and the 92-kD type IV collagenase responding most strongly and TIMP actually decreasing in certain cases. Tetradecanoylphorbol Acetate 21-55 TIMP metallopeptidase inhibitor 1 Homo sapiens 261-265 2159816-2 1990 We have studied the expression of the EPA/TIMP gene at the mRNA and protein levels during 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced megakaryoblastic differentiation of K562 human chronic myeloid leukemia cells. Tetradecanoylphorbol Acetate 90-127 TIMP metallopeptidase inhibitor 1 Homo sapiens 42-46 2159816-2 1990 We have studied the expression of the EPA/TIMP gene at the mRNA and protein levels during 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced megakaryoblastic differentiation of K562 human chronic myeloid leukemia cells. Tetradecanoylphorbol Acetate 129-132 TIMP metallopeptidase inhibitor 1 Homo sapiens 42-46 2159816-3 1990 Northern hybridization analysis showed that the EPA/TIMP mRNA was increased within 3 hours of TPA-induction and reached maximal levels (about 50-fold induction) during the first day of treatment. Tetradecanoylphorbol Acetate 94-97 TIMP metallopeptidase inhibitor 1 Homo sapiens 52-56 2159816-5 1990 The increase of EPA/TIMP mRNA correlated with increased EPA/TIMP protein biosynthesis and secretion: the TPA-induced cells secreted substantially enhanced amounts of metabolically labeled proteins, of which EPA/TIMP represented up to 50% after the first day of treatment (over 100-fold induction). Tetradecanoylphorbol Acetate 105-108 TIMP metallopeptidase inhibitor 1 Homo sapiens 20-24 2159816-5 1990 The increase of EPA/TIMP mRNA correlated with increased EPA/TIMP protein biosynthesis and secretion: the TPA-induced cells secreted substantially enhanced amounts of metabolically labeled proteins, of which EPA/TIMP represented up to 50% after the first day of treatment (over 100-fold induction). Tetradecanoylphorbol Acetate 105-108 TIMP metallopeptidase inhibitor 1 Homo sapiens 60-64 2159816-5 1990 The increase of EPA/TIMP mRNA correlated with increased EPA/TIMP protein biosynthesis and secretion: the TPA-induced cells secreted substantially enhanced amounts of metabolically labeled proteins, of which EPA/TIMP represented up to 50% after the first day of treatment (over 100-fold induction). Tetradecanoylphorbol Acetate 105-108 TIMP metallopeptidase inhibitor 1 Homo sapiens 60-64 2159816-7 1990 EPA/TIMP induction required continuous protein synthesis, being completely inhibited by addition of the protein synthesis inhibitor cycloheximide simultaneously with TPA, but only partially inhibited in a time-dependent manner if cycloheximide was added after TPA. Tetradecanoylphorbol Acetate 166-169 TIMP metallopeptidase inhibitor 1 Homo sapiens 4-8 2159816-7 1990 EPA/TIMP induction required continuous protein synthesis, being completely inhibited by addition of the protein synthesis inhibitor cycloheximide simultaneously with TPA, but only partially inhibited in a time-dependent manner if cycloheximide was added after TPA. Tetradecanoylphorbol Acetate 260-263 TIMP metallopeptidase inhibitor 1 Homo sapiens 4-8 2159816-9 1990 This response was associated with enhanced activity of a transfected recombinant reporter plasmid containing binding sites for the jun/fos transcription factor complex (AP-1) similar to the TPA-responsive element (TRE) sequence we found in the EPA/TIMP gene promoter. Tetradecanoylphorbol Acetate 190-193 TIMP metallopeptidase inhibitor 1 Homo sapiens 248-252 2991920-4 1985 However, upon exposure to 1,25-dihydroxyvitamin D3 or phorbol esters (PMA), both of which promote monocytic differentiation of HL60, these cells synthesized and released CI in a dose-dependent manner. Tetradecanoylphorbol Acetate 70-73 TIMP metallopeptidase inhibitor 1 Homo sapiens 170-172 2992392-0 1985 Coregulation of collagenase and collagenase inhibitor production by phorbol myristate acetate in human skin fibroblasts. Tetradecanoylphorbol Acetate 68-93 TIMP metallopeptidase inhibitor 1 Homo sapiens 32-53 2992392-1 1985 Phorbol myristate acetate (PMA), a tumor promotor known to stimulate collagenase production in fibroblasts and endothelial cells, was examined with regard to its ability to regulate the expression of the collagenase inhibitor secreted by human skin fibroblasts. Tetradecanoylphorbol Acetate 0-25 TIMP metallopeptidase inhibitor 1 Homo sapiens 204-225 2992392-1 1985 Phorbol myristate acetate (PMA), a tumor promotor known to stimulate collagenase production in fibroblasts and endothelial cells, was examined with regard to its ability to regulate the expression of the collagenase inhibitor secreted by human skin fibroblasts. Tetradecanoylphorbol Acetate 27-30 TIMP metallopeptidase inhibitor 1 Homo sapiens 204-225 2992392-3 1985 PMA stimulated the production of both collagenase and collagenase inhibitor in several cell lines to maximal rates that were very similar, 300 to 350 vs 230 to 330 pmol 10 micrograms DNA-1 48 h-1, respectively. Tetradecanoylphorbol Acetate 0-3 TIMP metallopeptidase inhibitor 1 Homo sapiens 54-75 23268563-6 2013 Under phorbol 12-myristate 13-acetate (PMA) incubation, 6-DG increased fibroblast collagen yield obviously, reduced matrix metalloproteinase-1 (MMP-1) protein expression, and recovered tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion. Tetradecanoylphorbol Acetate 6-37 TIMP metallopeptidase inhibitor 1 Homo sapiens 185-224 27476935-4 2016 In contrast, p-cymene enhanced the TPA-augmented production and gene expression of TIMP-1 in HT-1080 cells. Tetradecanoylphorbol Acetate 35-38 TIMP metallopeptidase inhibitor 1 Homo sapiens 83-89 2982848-5 1985 Secretion of TIMP was stimulated up to 10-fold by treating the cells with 20-100 ng/ml of 12-O-tetradecanoylphorbol 13-acetate or 10 units/ml of human interleukin 1. Tetradecanoylphorbol Acetate 90-126 TIMP metallopeptidase inhibitor 1 Homo sapiens 13-17 3894382-4 1985 The phorbol ester, 12-O-tetradecanoylphorbol-13-acetate, was used to stimulate secretion of TIMP by human foetal lung fibroblasts and the ionophore monensin was used to demonstrate intracellular accumulation of TIMP in the Golgi apparatus of these cells. Tetradecanoylphorbol Acetate 19-55 TIMP metallopeptidase inhibitor 1 Homo sapiens 92-96 23268563-6 2013 Under phorbol 12-myristate 13-acetate (PMA) incubation, 6-DG increased fibroblast collagen yield obviously, reduced matrix metalloproteinase-1 (MMP-1) protein expression, and recovered tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion. Tetradecanoylphorbol Acetate 6-37 TIMP metallopeptidase inhibitor 1 Homo sapiens 226-232 23268563-6 2013 Under phorbol 12-myristate 13-acetate (PMA) incubation, 6-DG increased fibroblast collagen yield obviously, reduced matrix metalloproteinase-1 (MMP-1) protein expression, and recovered tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion. Tetradecanoylphorbol Acetate 39-42 TIMP metallopeptidase inhibitor 1 Homo sapiens 185-224 23268563-6 2013 Under phorbol 12-myristate 13-acetate (PMA) incubation, 6-DG increased fibroblast collagen yield obviously, reduced matrix metalloproteinase-1 (MMP-1) protein expression, and recovered tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion. Tetradecanoylphorbol Acetate 39-42 TIMP metallopeptidase inhibitor 1 Homo sapiens 226-232 21354279-4 2011 We found that piperine suppresses PMA-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB and AP-1 activation without changing the level of tissue inhibitor of metalloproteinase (TIMP)-1. Tetradecanoylphorbol Acetate 34-37 TIMP metallopeptidase inhibitor 1 Homo sapiens 229-275 22974092-8 2012 The baseline values of CEA, TPA and TIMP-1 were also significantly correlated to PFS and TPA to RR. Tetradecanoylphorbol Acetate 89-92 TIMP metallopeptidase inhibitor 1 Homo sapiens 36-42 21925496-3 2011 The present study aimed to investigate the modulating effects of cilostazol on monocyte invasion and the gene expressions of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1. Tetradecanoylphorbol Acetate 223-254 TIMP metallopeptidase inhibitor 1 Homo sapiens 164-210 21925496-3 2011 The present study aimed to investigate the modulating effects of cilostazol on monocyte invasion and the gene expressions of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1. Tetradecanoylphorbol Acetate 223-254 TIMP metallopeptidase inhibitor 1 Homo sapiens 212-218 21925496-3 2011 The present study aimed to investigate the modulating effects of cilostazol on monocyte invasion and the gene expressions of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1. Tetradecanoylphorbol Acetate 256-259 TIMP metallopeptidase inhibitor 1 Homo sapiens 212-218 20471972-10 2010 Different concentration PMA enhanced TIMP-1 mRNA expression, but IL-1beta did not affect the TIMP-1 mRNA expression. Tetradecanoylphorbol Acetate 24-27 TIMP metallopeptidase inhibitor 1 Homo sapiens 37-43