PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8672532-5	1996	Phospholipase C activating agents (carbachol, CCK-8), adenylate cyclase activating agents (secretin, VIP), TPA and the calcium ionophore, A23187, all inhibited the binding of 125I-BH-SP and it was due to inhibition of ligand internalization with no change in surface bound parameters.	Tetradecanoylphorbol Acetate	107-110	tachykinin precursor 1	Homo sapiens	183-185	
10402232-7	1999	We recently demonstrated that the ability of substance P (SP) neuropeptide to activate MAP kinase pathway in U-373MG astrocytoma cells correlates with its ability to selectively translocate PKCepsilon from cytosolic to membrane fraction, and that PKC inhibitors (e.g. CGP 41251) inhibit the activation of this pathway by SP or the PKC activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	345-382	tachykinin precursor 1	Homo sapiens	45-56	
10402232-7	1999	We recently demonstrated that the ability of substance P (SP) neuropeptide to activate MAP kinase pathway in U-373MG astrocytoma cells correlates with its ability to selectively translocate PKCepsilon from cytosolic to membrane fraction, and that PKC inhibitors (e.g. CGP 41251) inhibit the activation of this pathway by SP or the PKC activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	345-382	tachykinin precursor 1	Homo sapiens	58-60	
10402232-7	1999	We recently demonstrated that the ability of substance P (SP) neuropeptide to activate MAP kinase pathway in U-373MG astrocytoma cells correlates with its ability to selectively translocate PKCepsilon from cytosolic to membrane fraction, and that PKC inhibitors (e.g. CGP 41251) inhibit the activation of this pathway by SP or the PKC activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	384-387	tachykinin precursor 1	Homo sapiens	45-56	
10402232-7	1999	We recently demonstrated that the ability of substance P (SP) neuropeptide to activate MAP kinase pathway in U-373MG astrocytoma cells correlates with its ability to selectively translocate PKCepsilon from cytosolic to membrane fraction, and that PKC inhibitors (e.g. CGP 41251) inhibit the activation of this pathway by SP or the PKC activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).	Tetradecanoylphorbol Acetate	384-387	tachykinin precursor 1	Homo sapiens	58-60	
9372245-4	1997	SP peptide, epidermal growth factor, and the PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) induced the tyrosine phosphorylation of the Erk1 and Erk2 MAP kinases in a concentration-dependent manner in U-373 MG cells.	Tetradecanoylphorbol Acetate	97-100	tachykinin precursor 1	Homo sapiens	0-2	
9372245-9	1997	Prolonged treatment with TPA resulted in down-regulation of PKC and selective inhibition of TPA- and SP-induced Erk1 and Erk2 tyrosine phosphorylation in U-373 MG cells.	Tetradecanoylphorbol Acetate	25-28	tachykinin precursor 1	Homo sapiens	101-103	
8808644-3	1996	Similarly to anti-IgE, two activators of protein kinase C, tetradecanoylphorbol acetate (TPA) and bryostatin 1, significantly inhibited the substance P-induced response.	Tetradecanoylphorbol Acetate	59-87	tachykinin precursor 1	Homo sapiens	140-151	
8808644-3	1996	Similarly to anti-IgE, two activators of protein kinase C, tetradecanoylphorbol acetate (TPA) and bryostatin 1, significantly inhibited the substance P-induced response.	Tetradecanoylphorbol Acetate	89-92	tachykinin precursor 1	Homo sapiens	140-151	
7679371-4	1993	The O2- production induced by substance P was also found to be fivefold higher in exudate cells, while the metabolic response to other stimulants such as concanavalin A (con A), phorbol-myristate acetate (PMA), NaF, and immunocomplexes was not primed.	Tetradecanoylphorbol Acetate	205-208	tachykinin precursor 1	Homo sapiens	30-41	
2430623-2	1986	Basal release and release in response to the beta-adrenergic agonist, terbutaline and 12-O-tetradecanoylphorbol 13-acetate (TPA) were significantly decreased in the presence of substance P.	Tetradecanoylphorbol Acetate	86-122	tachykinin precursor 1	Homo sapiens	177-188	
2430623-2	1986	Basal release and release in response to the beta-adrenergic agonist, terbutaline and 12-O-tetradecanoylphorbol 13-acetate (TPA) were significantly decreased in the presence of substance P.	Tetradecanoylphorbol Acetate	124-127	tachykinin precursor 1	Homo sapiens	177-188	
2430623-3	1986	Inhibitory effects of substance P were noted following a 1 h exposure of primary cultures of Type II cells in vitro and persisted up to 3 h in the presence of the secretagogues, TPA and terbutaline.	Tetradecanoylphorbol Acetate	178-181	tachykinin precursor 1	Homo sapiens	22-33	
2430623-4	1986	The IC50 values for substance P inhibition of [3H]PC release were 10 microM for basal release, 40 microM for TPA-induced release and 50 microM for terbutaline-induced release.	Tetradecanoylphorbol Acetate	109-112	tachykinin precursor 1	Homo sapiens	20-31