PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11892999-9 2001 Furthermore, we have shown that the IL-6 receptor complex is functional in U-937-1 cells induced to differentiate towards a secretory macrophage by treatment with PMA. Tetradecanoylphorbol Acetate 163-166 interleukin 6 Homo sapiens 36-40 11356008-3 2001 Here, we report that IL-6 and 12-O-tetradecanoylphorbol-13-acetate (TPA) synergistically transactivate the IRE in HepG2 cells, which is coupled to a strong upregulation of c-Jun and c-Fos expression by TPA via the mitogen-activated protein kinase (MAPK) pathway. Tetradecanoylphorbol Acetate 202-205 interleukin 6 Homo sapiens 21-25 10928984-6 2000 Coincubation with OPC cell lines with conditioned medium from a TPA-exposed HL-60 cells stimulated growth proportional to the IL-6 levels measured in the conditioned medium. Tetradecanoylphorbol Acetate 64-67 interleukin 6 Homo sapiens 126-130 11053033-3 2000 Triptolide, with an IC(50) of approximately 20-50 ng/ml, inhibits normal and transformed human bronchial epithelial cell expression of interleukin (IL)-6 and IL-8 stimulated by phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-alpha, or IL-1 beta. Tetradecanoylphorbol Acetate 177-208 interleukin 6 Homo sapiens 135-153 11053033-3 2000 Triptolide, with an IC(50) of approximately 20-50 ng/ml, inhibits normal and transformed human bronchial epithelial cell expression of interleukin (IL)-6 and IL-8 stimulated by phorbol 12-myristate 13-acetate (PMA), tumor necrosis factor-alpha, or IL-1 beta. Tetradecanoylphorbol Acetate 210-213 interleukin 6 Homo sapiens 135-153 10922477-1 2000 Prior activation of mitogen-activated protein kinases by phorbol 13-myristate 12-acetate (PMA) results in an inhibition of interleukin (IL)-6-induced activation of the Janus kinase/signal transducer and activator of transcription (STAT) signaling pathway which is most likely mediated by the induction of suppressor of cytokine signaling-3 and requires the specific SHP2 binding site Y759 of the IL-6 signal transducer gp130. Tetradecanoylphorbol Acetate 90-93 interleukin 6 Homo sapiens 123-141 10922477-1 2000 Prior activation of mitogen-activated protein kinases by phorbol 13-myristate 12-acetate (PMA) results in an inhibition of interleukin (IL)-6-induced activation of the Janus kinase/signal transducer and activator of transcription (STAT) signaling pathway which is most likely mediated by the induction of suppressor of cytokine signaling-3 and requires the specific SHP2 binding site Y759 of the IL-6 signal transducer gp130. Tetradecanoylphorbol Acetate 90-93 interleukin 6 Homo sapiens 396-400 10922477-2 2000 In this study, we demonstrate that PMA inhibits STAT activation by IL-6 and the related cytokine leukemia inhibitory factor (LIF) but not by oncostatin M (OSM). Tetradecanoylphorbol Acetate 35-38 interleukin 6 Homo sapiens 67-71 10880263-5 2000 Phorbol-12-myristate-13-acetate (PMA), calcium ionophore A23187, TNF-alpha, IL-1beta, oncostatin M (OSM) but not lipopolysaccharide stimulated IL-6 production from gastric epithelial cell line MKN-28. Tetradecanoylphorbol Acetate 0-31 interleukin 6 Homo sapiens 143-147 10764798-1 2000 Mitogen-activated protein (MAP) kinases stimulated by phorbol 13-myristate 12-acetate (PMA) have been shown to inhibit interleukin-6-induced activation of STAT3 (Sengupta, T. K., Talbot, E. S., Scherle, P. A., and Ivashkiv, L. B. Tetradecanoylphorbol Acetate 87-90 interleukin 6 Homo sapiens 119-132 10833370-5 2000 IL-6 transcription and secretion were dose-dependently enhanced by stimulation with IL-1beta, tumour necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta1 and 12-O-tetradecanoyl phorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 173-210 interleukin 6 Homo sapiens 0-4 10833370-5 2000 IL-6 transcription and secretion were dose-dependently enhanced by stimulation with IL-1beta, tumour necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta1 and 12-O-tetradecanoyl phorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 212-215 interleukin 6 Homo sapiens 0-4 10833370-8 2000 The TPA-induced production of IL-6 was inhibited by 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine and sphyngosine, suggesting the involvement of a protein kinase C-dependent pathway. Tetradecanoylphorbol Acetate 4-7 interleukin 6 Homo sapiens 30-34 10446065-4 1999 When treated with IL-6, macrophages derived from peripheral monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells showed significantly reduced uptake and/or binding of the MSR ligand, acetylated LDL. Tetradecanoylphorbol Acetate 74-105 interleukin 6 Homo sapiens 18-22 10613356-1 1999 It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells. Tetradecanoylphorbol Acetate 34-65 interleukin 6 Homo sapiens 138-151 10613356-1 1999 It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells. Tetradecanoylphorbol Acetate 34-65 interleukin 6 Homo sapiens 153-157 10613356-1 1999 It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells. Tetradecanoylphorbol Acetate 34-65 interleukin 6 Homo sapiens 163-167 10613356-1 1999 It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells. Tetradecanoylphorbol Acetate 67-70 interleukin 6 Homo sapiens 138-151 10613356-1 1999 It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells. Tetradecanoylphorbol Acetate 67-70 interleukin 6 Homo sapiens 153-157 10613356-1 1999 It has been previously shown that phorbol 12-myristate 13-acetate (PMA), a potent differentiation inducer, induced the expression of both interleukin-6 (IL-6) and IL-6 receptor alpha component (IL-6Ralpha) in K562 leukemia cells. Tetradecanoylphorbol Acetate 67-70 interleukin 6 Homo sapiens 163-167 10446065-4 1999 When treated with IL-6, macrophages derived from peripheral monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 monocytic cells showed significantly reduced uptake and/or binding of the MSR ligand, acetylated LDL. Tetradecanoylphorbol Acetate 107-110 interleukin 6 Homo sapiens 18-22 9504629-4 1998 Mitogenic stimulation with phorbol 12-myristate 13-acetate (PMA) or PMA plus interleukin-2 (IL-2) resulted in a tremendous increase in TNF-alpha and IL-6 production in cells representing early stage (Binet A) disease. Tetradecanoylphorbol Acetate 27-58 interleukin 6 Homo sapiens 149-153 9740146-10 1998 TPA (10 nmol/L) also stimulated the production of IL-6 and IL-8 by these cells, but inhibited that of monocyte chemoattractant protein-1. Tetradecanoylphorbol Acetate 0-3 interleukin 6 Homo sapiens 50-54 10023015-8 1999 Especially in kidney cell lines, the levels of granulocyte-macrophage-CSF (GM-CSF), M-CSF and IL-6 were further strongly increased by the TPA and IL-1 pretreatment. Tetradecanoylphorbol Acetate 138-141 interleukin 6 Homo sapiens 94-98 9885283-7 1999 ATP stimulation triggered release of the pro-inflammatory cytokine IL-6 in fibroblasts pre-treated with PMA and bacterial endotoxin. Tetradecanoylphorbol Acetate 104-107 interleukin 6 Homo sapiens 67-71 10191628-4 1999 Flow cytometric detection of intracellular cytokines in tonsillar mononuclear cells stimulated with PMA and ionomycin revealed that CD3 cells produced IL-1 alpha, IL-2, IL-4, IL-8, IFN-gamma and TNF-alpha, and CD19 cells produced IL-1 alpha, IL-6, IL-8 and TFN-alpha. Tetradecanoylphorbol Acetate 100-103 interleukin 6 Homo sapiens 242-246 10704080-3 1999 We measured the effect of CsA on basal and phorbol-myristate-acetate (PMA)-stimulated production of interleukin-6 using the human monocyte cell line U937 differentiated with dimethylsulfoxide (DMSO). Tetradecanoylphorbol Acetate 43-68 interleukin 6 Homo sapiens 100-113 10704080-3 1999 We measured the effect of CsA on basal and phorbol-myristate-acetate (PMA)-stimulated production of interleukin-6 using the human monocyte cell line U937 differentiated with dimethylsulfoxide (DMSO). Tetradecanoylphorbol Acetate 70-73 interleukin 6 Homo sapiens 100-113 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Tetradecanoylphorbol Acetate 218-249 interleukin 6 Homo sapiens 56-69 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Tetradecanoylphorbol Acetate 218-249 interleukin 6 Homo sapiens 71-75 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Tetradecanoylphorbol Acetate 218-249 interleukin 6 Homo sapiens 268-272 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Tetradecanoylphorbol Acetate 251-254 interleukin 6 Homo sapiens 56-69 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Tetradecanoylphorbol Acetate 251-254 interleukin 6 Homo sapiens 71-75 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Tetradecanoylphorbol Acetate 251-254 interleukin 6 Homo sapiens 268-272 9408252-7 1997 Production of both IL-6 and IL-8 was stimulated in a concentration-dependent fashion by interleukin-1beta (0.1-10 ng/ml), tumor necrosis factor-alpha (1-100 ng/ml), and bacterial lipopolysaccharide (0.1-10 microg/ml), and also by 100 nM phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 237-268 interleukin 6 Homo sapiens 19-23 9504629-4 1998 Mitogenic stimulation with phorbol 12-myristate 13-acetate (PMA) or PMA plus interleukin-2 (IL-2) resulted in a tremendous increase in TNF-alpha and IL-6 production in cells representing early stage (Binet A) disease. Tetradecanoylphorbol Acetate 60-63 interleukin 6 Homo sapiens 149-153 9504629-4 1998 Mitogenic stimulation with phorbol 12-myristate 13-acetate (PMA) or PMA plus interleukin-2 (IL-2) resulted in a tremendous increase in TNF-alpha and IL-6 production in cells representing early stage (Binet A) disease. Tetradecanoylphorbol Acetate 68-71 interleukin 6 Homo sapiens 149-153 9504629-7 1998 The most remarkable difference was recorded in PMA-stimulated (1 ng/ml) IL-6 production. Tetradecanoylphorbol Acetate 47-50 interleukin 6 Homo sapiens 72-76 9368513-4 1997 The effects of dexamethasone and 17 beta-oestradiol on IL-1-, TNF-, TSH-, forskolin- and phorbol 12-myristate 13-acetate (PMA)-stimulated IL-6 release in serum-free conditions were studied in human thyrocytes derived from patients with Graves" disease and toxic multinodular goitres, and in the immortalised human thyrocyte cell line, HTori3. Tetradecanoylphorbol Acetate 89-120 interleukin 6 Homo sapiens 138-142 9368513-4 1997 The effects of dexamethasone and 17 beta-oestradiol on IL-1-, TNF-, TSH-, forskolin- and phorbol 12-myristate 13-acetate (PMA)-stimulated IL-6 release in serum-free conditions were studied in human thyrocytes derived from patients with Graves" disease and toxic multinodular goitres, and in the immortalised human thyrocyte cell line, HTori3. Tetradecanoylphorbol Acetate 122-125 interleukin 6 Homo sapiens 138-142 9125669-4 1997 IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide. Tetradecanoylphorbol Acetate 131-134 interleukin 6 Homo sapiens 68-72 9246192-6 1997 At the transcriptional level, a slight increase of IL-6 transcripts was already detectable 1 h after irradiation, with maximum levels at 2 h, and a decline to baseline levels between 8 and 24 h. Addition of the transcriptional inhibitor actinomycin D inhibited the inducibility of IL-6 mRNA by TPA and IR. Tetradecanoylphorbol Acetate 294-297 interleukin 6 Homo sapiens 51-55 9246192-8 1997 All corticosteroids applied could efficiently downregulate TPA- or radiation-induced IL-6 expression on both gene expression and protein levels. Tetradecanoylphorbol Acetate 59-62 interleukin 6 Homo sapiens 85-89 9169347-5 1997 Agonists for protein kinase A (PKA) (forskolin), and protein kinase C (PKC) (phorbol 12-myristate 13-acetate; PMA) also stimulated IL-6/IL-11 production. Tetradecanoylphorbol Acetate 77-108 interleukin 6 Homo sapiens 131-135 9500150-11 1997 Pretreatment of C6 glioma cells with 1 microM phorbol myristate acetate (PMA) for 24 h completely blocked the subsequent stimulation of IL-6 release by PMA (20-250 nM) and partially blocked by 50% the TF5 stimulation of this cytokine. Tetradecanoylphorbol Acetate 46-71 interleukin 6 Homo sapiens 136-140 9500150-11 1997 Pretreatment of C6 glioma cells with 1 microM phorbol myristate acetate (PMA) for 24 h completely blocked the subsequent stimulation of IL-6 release by PMA (20-250 nM) and partially blocked by 50% the TF5 stimulation of this cytokine. Tetradecanoylphorbol Acetate 73-76 interleukin 6 Homo sapiens 136-140 9500150-11 1997 Pretreatment of C6 glioma cells with 1 microM phorbol myristate acetate (PMA) for 24 h completely blocked the subsequent stimulation of IL-6 release by PMA (20-250 nM) and partially blocked by 50% the TF5 stimulation of this cytokine. Tetradecanoylphorbol Acetate 152-155 interleukin 6 Homo sapiens 136-140 9154298-13 1997 The increase in IL-6 luciferase activity occurs in the absence of the multiple response region, the area of the IL-6 promoter responsive to IL-1, TNF alpha, cyclic amp, and phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 173-204 interleukin 6 Homo sapiens 16-20 9154298-13 1997 The increase in IL-6 luciferase activity occurs in the absence of the multiple response region, the area of the IL-6 promoter responsive to IL-1, TNF alpha, cyclic amp, and phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 173-204 interleukin 6 Homo sapiens 112-116 9010683-6 1996 Treatment of THP-1 cells with PMA and LPS caused the highest production of both IL-1 beta and IL-6 (> 5ng/ml). Tetradecanoylphorbol Acetate 30-33 interleukin 6 Homo sapiens 94-98 9169347-10 1997 Similarly, 17 beta-E2 inhibited PMA-stimulated IL-6 production, whereas neither forskolin-stimulated IL-6/ IL-11 production nor PMA-stimulated IL-11 production was affected by 17 beta-E2. Tetradecanoylphorbol Acetate 32-35 interleukin 6 Homo sapiens 47-51 18472849-2 1997 Phorbol-12-myristate 13 acetate (PMA) caused a decrease in the levels of IL-6 in 14 out of 16 cultures and an increase in levels of sIL6R in all 15 cases. Tetradecanoylphorbol Acetate 0-31 interleukin 6 Homo sapiens 73-77 18472849-2 1997 Phorbol-12-myristate 13 acetate (PMA) caused a decrease in the levels of IL-6 in 14 out of 16 cultures and an increase in levels of sIL6R in all 15 cases. Tetradecanoylphorbol Acetate 33-36 interleukin 6 Homo sapiens 73-77 9125669-4 1997 IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide. Tetradecanoylphorbol Acetate 131-134 interleukin 6 Homo sapiens 143-147 9125669-4 1997 IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide. Tetradecanoylphorbol Acetate 227-230 interleukin 6 Homo sapiens 68-72 9125669-4 1997 IL-1, a physiological activator of PKC, induced a rapid increase in IL-6 messenger RNA (mRNA) levels, which was sustained at 24 h. PMA-induced IL-6 mRNA levels in RASMC were markedly attenuated after downregulation of PKC with PMA and by the selective PKC inhibitor, bisindolylmaleimide. Tetradecanoylphorbol Acetate 227-230 interleukin 6 Homo sapiens 143-147 8780895-7 1996 Upon incubation with differentiation inducers such as 12-O-tetradecanoylphorbol-13-acetate, lipopolysaccharide, a combination of interleukin (IL) 6 plus tumor necrosis factor (TNF) alpha, or IFN-gamma plus TNF-alpha, a pronounced increase in the amounts of Met mRNA and protein are seen in THP-1 cells. Tetradecanoylphorbol Acetate 54-90 interleukin 6 Homo sapiens 129-147 8798409-1 1996 We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A). Tetradecanoylphorbol Acetate 51-82 interleukin 6 Homo sapiens 109-122 8798409-1 1996 We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A). Tetradecanoylphorbol Acetate 51-82 interleukin 6 Homo sapiens 124-128 8798409-1 1996 We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A). Tetradecanoylphorbol Acetate 84-87 interleukin 6 Homo sapiens 109-122 8798409-1 1996 We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A). Tetradecanoylphorbol Acetate 84-87 interleukin 6 Homo sapiens 124-128 7642569-12 1995 Pretreatment of cells with phorbol 12-myristate 13-acetate for 15 min, to activate protein kinase C, resulted in inhibition of the IL-6-induced SIF response (10 min). Tetradecanoylphorbol Acetate 27-58 interleukin 6 Homo sapiens 131-135 8630547-7 1996 Similarly, BAL-derived cells displayed significantly increased phorbol myristate acetate-stimulated release of superoxide anion (8.8 +/- 1.3 versus 4.5 +/- 0.7 nmol/5 x 10 5 cells/h; p<0.01) for the oldest versus youngest subject group, and mean BAL IL-6 concentrations were significantly elevated in the oldest age group (0.86 +/- 0.13 ng/ml) compared with the youngest age group (0.53 +/- 0.03 ng/ml; p<0.01). Tetradecanoylphorbol Acetate 63-88 interleukin 6 Homo sapiens 253-257 8592085-3 1996 Transcription of IL-6 mRNA was first detectable 2 h after stimulation with the ester phorbol myristate acetate (PMA) and the calcium ionophore A23187 in both cell lines, as evidenced by semiquantitative reverse transcriptase polymerase chain reaction analysis. Tetradecanoylphorbol Acetate 85-110 interleukin 6 Homo sapiens 17-21 8592085-3 1996 Transcription of IL-6 mRNA was first detectable 2 h after stimulation with the ester phorbol myristate acetate (PMA) and the calcium ionophore A23187 in both cell lines, as evidenced by semiquantitative reverse transcriptase polymerase chain reaction analysis. Tetradecanoylphorbol Acetate 112-115 interleukin 6 Homo sapiens 17-21 7595543-6 1995 The phorbol ester 12-O-tetradecanoylphorbol 13-acetate induced interleukin-6 production, and treatment with a combination of this phorbol ester and interleukin-1 produced synergistic stimulation. Tetradecanoylphorbol Acetate 18-54 interleukin 6 Homo sapiens 63-76 8632663-3 1995 TPA treatment also enhanced the expression of GPIIb mRNA, and induced the expression of interleukin-6 (IL-6) and its receptor mRNAs, while it did not induce transcripts of the genes IL-11 and mpl ligand, and further decreased the transcript of the mpl gene. Tetradecanoylphorbol Acetate 0-3 interleukin 6 Homo sapiens 88-101 8632663-3 1995 TPA treatment also enhanced the expression of GPIIb mRNA, and induced the expression of interleukin-6 (IL-6) and its receptor mRNAs, while it did not induce transcripts of the genes IL-11 and mpl ligand, and further decreased the transcript of the mpl gene. Tetradecanoylphorbol Acetate 0-3 interleukin 6 Homo sapiens 103-107 7615975-4 1995 Transforming growth factor (TGF)-alpha, epidermal growth factor, and phorbol myristate acetate also enhanced the secretion of VPF/VEGF by keratinocytes; in contrast, a number of other cytokines including interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor-alpha, interferon-gamma, and transforming growth factor-beta did not induce VPF/VEGF secretion. Tetradecanoylphorbol Acetate 69-94 interleukin 6 Homo sapiens 224-228 7914891-7 1994 Differentiation of U937 cells by exposure to 12-O-tetradecanoyl phorbol-13-acetate abolishes response to IL-6 but not IFN-gamma. Tetradecanoylphorbol Acetate 45-82 interleukin 6 Homo sapiens 105-109 7851022-13 1995 Stimulation with phytohaemagglutinin (PHA) and phorbol myristate acetate (PMA) induced most TCC to produce higher amounts of TNF-alpha, IL-2 and IL-6. Tetradecanoylphorbol Acetate 47-72 interleukin 6 Homo sapiens 145-149 7851022-13 1995 Stimulation with phytohaemagglutinin (PHA) and phorbol myristate acetate (PMA) induced most TCC to produce higher amounts of TNF-alpha, IL-2 and IL-6. Tetradecanoylphorbol Acetate 74-77 interleukin 6 Homo sapiens 145-149 7865515-7 1994 Activation of six additional isolates of lymphocytes with phorbol myristate acetate before exposure to human aortic endothelial cells resulted in an increase in human aortic endothelial cell-derived interleukin-6 bioactivity regardless of whether the cells were in direct contact with the human aortic endothelial cells, but the interleukin-6 level increase was approximately twofold higher in those cocultures where there was direct contact. Tetradecanoylphorbol Acetate 58-83 interleukin 6 Homo sapiens 199-212 7865515-7 1994 Activation of six additional isolates of lymphocytes with phorbol myristate acetate before exposure to human aortic endothelial cells resulted in an increase in human aortic endothelial cell-derived interleukin-6 bioactivity regardless of whether the cells were in direct contact with the human aortic endothelial cells, but the interleukin-6 level increase was approximately twofold higher in those cocultures where there was direct contact. Tetradecanoylphorbol Acetate 58-83 interleukin 6 Homo sapiens 329-342 7519668-9 1994 Indeed, phorbol 12-myristate 13-acetate, a protein kinase C activator, also evoked IL-6 release from the U373MG cells. Tetradecanoylphorbol Acetate 8-39 interleukin 6 Homo sapiens 83-87 7731274-6 1994 A significant increase in IL-6 production after mitogen stimulation with tetradecanoylphorbol acetate (TPA) and phytohemagglutinin (PHA) after 24 and 48 h of culture, as well as a greater induced TNF alpha production after 48 h of incubation with the same mitogens, was found in the anorectic patients as compared with the elderly controls. Tetradecanoylphorbol Acetate 73-101 interleukin 6 Homo sapiens 26-30 7731274-6 1994 A significant increase in IL-6 production after mitogen stimulation with tetradecanoylphorbol acetate (TPA) and phytohemagglutinin (PHA) after 24 and 48 h of culture, as well as a greater induced TNF alpha production after 48 h of incubation with the same mitogens, was found in the anorectic patients as compared with the elderly controls. Tetradecanoylphorbol Acetate 103-106 interleukin 6 Homo sapiens 26-30 7912755-10 1994 Culture supernatants from blasts cultured with or without TPA showed the production of large amounts of IL-8, IL-6, TNF-alpha, MIP-1 alpha, IL-10 and interferon gamma and modest amounts of IL-1 alpha, GM-CSF and stem cell factor. Tetradecanoylphorbol Acetate 58-61 interleukin 6 Homo sapiens 110-114 8045498-5 1994 Interleukin-1 beta and phorbol myristate acetate were also shown to induce in a dose-dependent fashion a threefold to fivefold increase of interleukin-6 production as measured by enzyme-linked immunosorbent assay in human primary biliary duct epithelium cultures, when compared with hepatocyte growth factor, epidermal growth factor, insulin-like growth factor, phytohemagglutinin, tumor necrosis factor-alpha or platelet-derived growth factor. Tetradecanoylphorbol Acetate 23-48 interleukin 6 Homo sapiens 139-152 8034686-2 1994 IL-6 expression is induced in young human diploid fibroblasts (HDF) in response to a number of agents including fetal bovine serum, 12-O-tetradecanoylphorbol-13-acetate, double-stranded RNA, and forskolin. Tetradecanoylphorbol Acetate 132-168 interleukin 6 Homo sapiens 0-4 8034686-3 1994 In contrast, we find that senescent HDF are markedly deficient in their ability to express IL-6 in response to serum, double-stranded RNA, and 12-O-tetradecanoyl-phorbol-13-acetate, whereas forskolin is still an effective inducer for senescent cells. Tetradecanoylphorbol Acetate 143-180 interleukin 6 Homo sapiens 91-95 8168335-9 1994 Both phorbol myristate acetate and N-formyl-methionyl-leucylphenylalanine induced further release of nitric oxide, which was increased by preincubation with lipopolysaccharide, interleukin-6 and interferon-gamma. Tetradecanoylphorbol Acetate 5-30 interleukin 6 Homo sapiens 177-190 7512730-6 1994 Either acidic fibroblast growth factor or phorbol 12-myristate 13-acetate can replace serum as a cofactor in IL-6-induced ZR-75-1-Tx cell detachment. Tetradecanoylphorbol Acetate 42-73 interleukin 6 Homo sapiens 109-113 8099851-2 1993 Interferon-gamma, interleukin-1, and interleukin-6 significantly increased adhesion; however, the highest adhesive response was obtained when cocultures were treated with phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 171-196 interleukin 6 Homo sapiens 37-50 8199014-3 1994 Co-stimulation with A23187 plus PMA resulted in an up-regulation of M-CSF mRNA and a down-regulation of IL-6 mRNA. Tetradecanoylphorbol Acetate 32-35 interleukin 6 Homo sapiens 104-108 7505212-7 1994 We also demonstrated that phorbol 12-myristate 13-acetate (PMA) or triggering of the CD28 molecule is an effective helper signal for IL-6 production by anti-CD3-stimulated T cells. Tetradecanoylphorbol Acetate 26-57 interleukin 6 Homo sapiens 133-137 7505212-7 1994 We also demonstrated that phorbol 12-myristate 13-acetate (PMA) or triggering of the CD28 molecule is an effective helper signal for IL-6 production by anti-CD3-stimulated T cells. Tetradecanoylphorbol Acetate 59-62 interleukin 6 Homo sapiens 133-137 8365378-7 1993 Stimulation by interleukin-6 (IL-6; 200 U/ml), epidermal growth factor (4 nM), and estradiol (10(-7) M) was 2- to 3-fold, whereas stimulations by tetradecanoylphorbol-13-acetate (TPA; 80 nM) and IL-1 (10 U/ml) were 2- to 5-fold and 5- to 10-fold, respectively. Tetradecanoylphorbol Acetate 179-182 interleukin 6 Homo sapiens 15-28 8245177-5 1993 PMA pretreatment of HEp-2 cells abolished PMA-induced IL-6 but the IL-1 effect was not reduced. Tetradecanoylphorbol Acetate 0-3 interleukin 6 Homo sapiens 54-58 8202627-1 1994 In human fibroblast cultures TPA increased IL-6 and IL-8 production. Tetradecanoylphorbol Acetate 29-32 interleukin 6 Homo sapiens 43-47 8398910-3 1993 It is reported here that IL-6 elevated the junB and c-jun mRNA levels and induced the formation of a novel DNA-protein complex with high sequence specificity to 12-O-tetradecanoylphorbol-13-acetate response element (TRE) oligonucleotides. Tetradecanoylphorbol Acetate 161-197 interleukin 6 Homo sapiens 25-29 8360592-5 1993 While phorbol myristate acetate-induced IL-1 beta and IL-8 mRNA expression was increased by RA (IL-6 could not be induced by this pathway in monocytes), IL-1 beta-induced expression of IL-1 beta and IL-8 was markedly reduced and IL-6 gene expression was almost completely suppressed. Tetradecanoylphorbol Acetate 6-31 interleukin 6 Homo sapiens 96-100 8360592-5 1993 While phorbol myristate acetate-induced IL-1 beta and IL-8 mRNA expression was increased by RA (IL-6 could not be induced by this pathway in monocytes), IL-1 beta-induced expression of IL-1 beta and IL-8 was markedly reduced and IL-6 gene expression was almost completely suppressed. Tetradecanoylphorbol Acetate 6-31 interleukin 6 Homo sapiens 229-233 8099851-2 1993 Interferon-gamma, interleukin-1, and interleukin-6 significantly increased adhesion; however, the highest adhesive response was obtained when cocultures were treated with phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 198-201 interleukin 6 Homo sapiens 37-50 8440709-7 1993 Exposure of HepG2 cells to phorbol 12-myristate 13-acetate (PMA) or PMA-dexamethasone led to an increase in the 80-kDa IL-6 receptor mRNA and functional receptor protein. Tetradecanoylphorbol Acetate 27-58 interleukin 6 Homo sapiens 119-123 8485909-2 1993 A strong hybridization signal for the IL-6 probe was observed in mRNA extracted from phytohaemagglutinin (PHA)- and PHA/phorbol myristate acetate (PMA)-stimulated PBMC from most of 12 CVI patients analysed. Tetradecanoylphorbol Acetate 120-145 interleukin 6 Homo sapiens 38-42 8485909-2 1993 A strong hybridization signal for the IL-6 probe was observed in mRNA extracted from phytohaemagglutinin (PHA)- and PHA/phorbol myristate acetate (PMA)-stimulated PBMC from most of 12 CVI patients analysed. Tetradecanoylphorbol Acetate 147-150 interleukin 6 Homo sapiens 38-42 8440709-7 1993 Exposure of HepG2 cells to phorbol 12-myristate 13-acetate (PMA) or PMA-dexamethasone led to an increase in the 80-kDa IL-6 receptor mRNA and functional receptor protein. Tetradecanoylphorbol Acetate 60-63 interleukin 6 Homo sapiens 119-123 8440709-8 1993 Whereas treatment of HepG2 cells with PMA led to an increase in the formation of gp80.gp130.IL-6 complexes determined by cross-linking, no corresponding increase in high affinity binding sites was found. Tetradecanoylphorbol Acetate 38-41 interleukin 6 Homo sapiens 92-96 8440709-10 1993 Evidence is presented that the 80-kDa IL-6 receptor up-regulation by PMA-dexamethasone is caused by the depletion of protein kinase C since the protein kinase C inhibitor staurosporine mimics the effect of PMA-dexamethasone. Tetradecanoylphorbol Acetate 69-72 interleukin 6 Homo sapiens 38-42 7679006-3 1993 However, in the presence of optimal concentrations of granulocyte colony-stimulating factor (G-CSF) or interleukin-6 (IL-6), TPA or bryostatin markedly elevated the number of colonies formed from the GM-CFC. Tetradecanoylphorbol Acetate 125-128 interleukin 6 Homo sapiens 118-122 8289985-4 1993 Calcitriol therapy resulted in significant increases in the phorbol myristate acetate (PMA)-induced secretion of IL-1 and IL-6 (p = 0.04 and 0.03, respectively). Tetradecanoylphorbol Acetate 60-85 interleukin 6 Homo sapiens 122-126 8440336-1 1993 The exposure of human peripheral blood mononuclear cells to extremely low frequency pulsed electromagnetic fields (PEMFs) increased both the spontaneous and the PHA- and TPA-induced production of interleukin-1 (IL-1) and IL-6. Tetradecanoylphorbol Acetate 170-173 interleukin 6 Homo sapiens 221-225 8289985-4 1993 Calcitriol therapy resulted in significant increases in the phorbol myristate acetate (PMA)-induced secretion of IL-1 and IL-6 (p = 0.04 and 0.03, respectively). Tetradecanoylphorbol Acetate 87-90 interleukin 6 Homo sapiens 122-126 1332971-1 1992 Transcription of interleukin-6 (IL-6) gene in human HepG2 and HeLa cells was induced by treatment with interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha), phorbol 12-myristate 13-acetate, or dibutyryl cyclic AMP. Tetradecanoylphorbol Acetate 166-197 interleukin 6 Homo sapiens 17-30 1332971-1 1992 Transcription of interleukin-6 (IL-6) gene in human HepG2 and HeLa cells was induced by treatment with interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-alpha), phorbol 12-myristate 13-acetate, or dibutyryl cyclic AMP. Tetradecanoylphorbol Acetate 166-197 interleukin 6 Homo sapiens 32-36 1496542-3 1992 PHA alone or in combination with PMA was the most effective stimulant in up-regulating IL-6 binding in all the experiments performed. Tetradecanoylphorbol Acetate 33-36 interleukin 6 Homo sapiens 87-91 1545152-4 1992 After 24 h of exposure to PMA, levels for most cytokines declined to baseline, except for IL-6 which appeared as a new transcript. Tetradecanoylphorbol Acetate 26-29 interleukin 6 Homo sapiens 90-94 1545152-5 1992 PMA-stimulated CMK lines synthesized low levels of TNF-alpha and IL-6, and higher levels of GM-CSF, IL-1 beta, and IL-1 alpha protein. Tetradecanoylphorbol Acetate 0-3 interleukin 6 Homo sapiens 65-69 1493924-4 1992 Further, 1,25(OH)2D3 inhibited the release of IL-6 in cultures of PHA-activated PBMC, whereas it stimulated IL-6 with the addition of PMA in these cultures. Tetradecanoylphorbol Acetate 134-137 interleukin 6 Homo sapiens 108-112 1496542-6 1992 The overall effect of the three pharmacological agents on mitogen-up-regulated IL-6 binding was minimal; most significant were a down-regulation by all three agents of IL-6 binding by small lymphocytes in PHA/PMA cultures, a down-regulation of IL-6 binding by CsA in PHA/PMA-induced large PBMC, and an up-regulation by verapamil of PMA-induced IL-6 binding in large PBMC. Tetradecanoylphorbol Acetate 209-212 interleukin 6 Homo sapiens 168-172 1496542-6 1992 The overall effect of the three pharmacological agents on mitogen-up-regulated IL-6 binding was minimal; most significant were a down-regulation by all three agents of IL-6 binding by small lymphocytes in PHA/PMA cultures, a down-regulation of IL-6 binding by CsA in PHA/PMA-induced large PBMC, and an up-regulation by verapamil of PMA-induced IL-6 binding in large PBMC. Tetradecanoylphorbol Acetate 209-212 interleukin 6 Homo sapiens 168-172 1496542-6 1992 The overall effect of the three pharmacological agents on mitogen-up-regulated IL-6 binding was minimal; most significant were a down-regulation by all three agents of IL-6 binding by small lymphocytes in PHA/PMA cultures, a down-regulation of IL-6 binding by CsA in PHA/PMA-induced large PBMC, and an up-regulation by verapamil of PMA-induced IL-6 binding in large PBMC. Tetradecanoylphorbol Acetate 209-212 interleukin 6 Homo sapiens 168-172 1391235-4 1992 Treatment of the two IL-6-producing melanoma cell lines with interleukin-1 beta, tumor necrosis factor-alpha, or phorbol myristate acetate caused a marked increase in IL-6 production. Tetradecanoylphorbol Acetate 113-138 interleukin 6 Homo sapiens 21-25 1391235-4 1992 Treatment of the two IL-6-producing melanoma cell lines with interleukin-1 beta, tumor necrosis factor-alpha, or phorbol myristate acetate caused a marked increase in IL-6 production. Tetradecanoylphorbol Acetate 113-138 interleukin 6 Homo sapiens 167-171 1779468-4 1991 On the contrary, IL-6 mRNA was detected by the method of RT-PCR, and its expression induced by the addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) could be clearly shown by Northern blotting. Tetradecanoylphorbol Acetate 111-147 interleukin 6 Homo sapiens 17-21 1425019-6 1992 High IL-6 production could be induced by stimulating the cells with a combination of phorbol-12-myristate 13-acetate (PMA) and anti-CD28 antibodies. Tetradecanoylphorbol Acetate 85-116 interleukin 6 Homo sapiens 5-9 1425019-6 1992 High IL-6 production could be induced by stimulating the cells with a combination of phorbol-12-myristate 13-acetate (PMA) and anti-CD28 antibodies. Tetradecanoylphorbol Acetate 118-121 interleukin 6 Homo sapiens 5-9 1779468-4 1991 On the contrary, IL-6 mRNA was detected by the method of RT-PCR, and its expression induced by the addition of 12-O-tetradecanoylphorbol-13-acetate (TPA) could be clearly shown by Northern blotting. Tetradecanoylphorbol Acetate 149-152 interleukin 6 Homo sapiens 17-21 2242429-11 1990 DNA synthesis induced by TPA/Ca2+ was blocked specifically by anti-IL-6 Ab; in contrast, the HCL proliferative response to SAC, TNF, or IL-4 and IL-5 was not inhibited by anti-IL-6 Ab. Tetradecanoylphorbol Acetate 25-28 interleukin 6 Homo sapiens 67-71 1653054-6 1991 12-O-tetradecanoyl phorbol-13-acetate (TPA) but not 8-bromoadenosine 3",5"-cyclic monophosphate (Br-cAMP) induces changes in the morphology and associative behavior of ZR-75-1 cells that are similar but not identical to those caused by IL-6. Tetradecanoylphorbol Acetate 0-37 interleukin 6 Homo sapiens 236-240 1653054-6 1991 12-O-tetradecanoyl phorbol-13-acetate (TPA) but not 8-bromoadenosine 3",5"-cyclic monophosphate (Br-cAMP) induces changes in the morphology and associative behavior of ZR-75-1 cells that are similar but not identical to those caused by IL-6. Tetradecanoylphorbol Acetate 39-42 interleukin 6 Homo sapiens 236-240 1713637-6 1991 In contrast, IL-1 beta, TNF, and TPA equally stimulated increased levels of M-CSF, GM-CSF, IL-1 beta and IL-6 RNAs. Tetradecanoylphorbol Acetate 33-36 interleukin 6 Homo sapiens 105-109 1989890-5 1991 After phorbol ester myristate acetate (PMA) treatment, all the cell lines studied expressed or overexpressed IL-6. Tetradecanoylphorbol Acetate 39-42 interleukin 6 Homo sapiens 109-113 1701344-2 1990 When cells were cultured in the presence of 12-O-tetradecanoylphorbol-13-acetate, significant amounts of IL6 were detected in the culture supernatants of Chang liver cells, HLF cells, and HLE cells. Tetradecanoylphorbol Acetate 44-80 interleukin 6 Homo sapiens 105-108 2242429-13 1990 Finally, peroxidase-antiperoxidase staining demonstrated that HCLs are induced by TPA/Ca2+, but not by SAC, to produce intracytoplasmic IL-6. Tetradecanoylphorbol Acetate 82-85 interleukin 6 Homo sapiens 136-140 2165096-9 1990 When added to PMA-stimulated SKW6.4 cells, IL-6 stimulated additional IgM production. Tetradecanoylphorbol Acetate 14-17 interleukin 6 Homo sapiens 43-47 2118969-9 1990 In contrast, PMA-induced IL-6 gene transcription was not affected by rIL-4. Tetradecanoylphorbol Acetate 13-16 interleukin 6 Homo sapiens 25-29 2113479-4 1990 Constitutive production of IL 6 in early passage lines could be enhanced by the phorbol ester phorbol 12-myristate 13-acetate (PMA) and recombinant (r)IL 4 but not by rIL 1 alpha or rIL 1 beta. Tetradecanoylphorbol Acetate 94-125 interleukin 6 Homo sapiens 27-31 2113479-4 1990 Constitutive production of IL 6 in early passage lines could be enhanced by the phorbol ester phorbol 12-myristate 13-acetate (PMA) and recombinant (r)IL 4 but not by rIL 1 alpha or rIL 1 beta. Tetradecanoylphorbol Acetate 127-130 interleukin 6 Homo sapiens 27-31 2162322-5 1990 The IL-6 activity in culture supernatants of EBV-transformed B cells, though much less than that of lipopolysaccharide (LPS)-stimulated monocytes, was increased by the addition of phorbol myristate acetate. Tetradecanoylphorbol Acetate 180-205 interleukin 6 Homo sapiens 4-8 33799840-0 2021 Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents. Tetradecanoylphorbol Acetate 121-124 interleukin 6 Homo sapiens 72-85 2183031-6 1990 Mutations in the NF-kappa B-binding site abolished inducibility of IL-6 promoter-cat constructs in U-937 cells by lipopolysaccharide, tumor necrosis factor alpha, the double-stranded RNA poly(IC), or phytohemagglutinin and in HeLa cells by tumor necrosis factor alpha and drastically reduced but did not completely eliminate inducibility in HeLa cells stimulated by double-stranded RNA poly(IC) or phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 398-429 interleukin 6 Homo sapiens 67-71 2294005-5 1990 IL-6 production was stimulated by phorbol myristate acetate (10-100 nM) approximately 2-fold and by lipopolysaccharide (0.001-10.0 micrograms/ml) 4-fold during 4-h incubations. Tetradecanoylphorbol Acetate 34-59 interleukin 6 Homo sapiens 0-4 33799840-2 2021 The aim of this study is to investigate the effects of hydrogen nano-bubble water (HW) on ROS generation, adipogenesis, and interleukin-6 (IL-6) secretion in hydrogen peroxide (H2O2) or phorbol 12-myristate 13-acetate (PMA)-stimulated OP9 adipocytes, and three-dimensional (3D) subcutaneous adipose equivalents. Tetradecanoylphorbol Acetate 186-217 interleukin 6 Homo sapiens 139-143 34732304-12 2021 The inflammatory cytokines, TNF-alpha and IL-6, were significantly increased after HDAC6 knockdown in PMA-stimulated THP1 cells and SW982 cells (p < 0.05). Tetradecanoylphorbol Acetate 102-105 interleukin 6 Homo sapiens 42-46 30919561-4 2019 In this study, it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells. Tetradecanoylphorbol Acetate 62-93 interleukin 6 Homo sapiens 108-112 34289257-5 2021 Interleukin (IL) 1beta, IL6, and tumor necrosis factor (TNF) alpha messenger RNA (mRNA) expressions were analyzed in freshly isolated and cultured PBMCs with phytohemagglutinin and phorbol myristate acetate stimulation by real-time reverse transcription polymerase chain reaction and serum MMP3 by enzyme-linked immunosorbent assay (ELISA). Tetradecanoylphorbol Acetate 181-206 interleukin 6 Homo sapiens 24-27 35612375-4 2022 In this study, we found that pro-inflammatory cytokines-IL-1beta, IL-6 and TNFalpha showed greater induction in phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells than in THP-1 cells. Tetradecanoylphorbol Acetate 112-143 interleukin 6 Homo sapiens 66-70 35612375-4 2022 In this study, we found that pro-inflammatory cytokines-IL-1beta, IL-6 and TNFalpha showed greater induction in phorbol-12-myristate-13-acetate (PMA)-differentiated THP-1 cells than in THP-1 cells. Tetradecanoylphorbol Acetate 145-148 interleukin 6 Homo sapiens 66-70 2544300-11 1989 However, IL-6 did "prime" PMN, enhancing superoxide secretion by fMLP (10(-7) M)-treated PMN by 50.8% (5.9 +/- 1.0 to 8.9 +/- 1.5 nmol superoxide at 100 U of IL-6; P less than 0.01) and PMA (5.0 nM) by 54.3% (8.1 +/- 2.6 to 12.5 +/- 3.6 nmol; P less than 0.05). Tetradecanoylphorbol Acetate 186-189 interleukin 6 Homo sapiens 9-13 2460462-2 1988 Phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), partially mimics the stimulatory effect of IL-6 but reduces that effect of IL-1. Tetradecanoylphorbol Acetate 15-51 interleukin 6 Homo sapiens 102-106 2460462-2 1988 Phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), partially mimics the stimulatory effect of IL-6 but reduces that effect of IL-1. Tetradecanoylphorbol Acetate 53-56 interleukin 6 Homo sapiens 102-106 2460462-4 1988 These regulatory properties of TPA are also manifested in HepG2 cells transiently transfected with an indicator gene construct carrying the IL-1/IL-6 regulatory enhancer element of the rat alpha 1-acid glycoprotein gene. Tetradecanoylphorbol Acetate 31-34 interleukin 6 Homo sapiens 145-149 2460462-5 1988 IL-6 and IL-1 act independently of TPA-inducible kinase C, and of changes in intracellular Ca2+ concentrations. Tetradecanoylphorbol Acetate 35-38 interleukin 6 Homo sapiens 0-4 2821154-8 1987 Several other cell lines, the histiocytic line U937, the promyelocytic line HL60, the astrocytoma line U373 and the glioblastoma line SK-MG-4, in which BSF-2 was inducible with IL-1 or TPA, displayed BSF-2-R with Kd in the range of 1.3-6.4 X 10(-10) M, suggesting the autocrine mechanism in BSF-2 function. Tetradecanoylphorbol Acetate 185-188 interleukin 6 Homo sapiens 152-157 32504994-9 2020 In phorbol myristate acetate (PMA)-stimulated A549 or H292 airway epithelial cells, pretreatment of THCA dose-dependently inhibited the generation of IL-6. Tetradecanoylphorbol Acetate 3-28 interleukin 6 Homo sapiens 150-154 32504994-9 2020 In phorbol myristate acetate (PMA)-stimulated A549 or H292 airway epithelial cells, pretreatment of THCA dose-dependently inhibited the generation of IL-6. Tetradecanoylphorbol Acetate 30-33 interleukin 6 Homo sapiens 150-154 32447451-5 2020 RESULTS: Stimulation of cells by PMA or LPS (without Actovegin ) significantly increased the secretion of IL-1beta, IL-6, IL-10 and TNF-alpha from PBMCs, compared to controls. Tetradecanoylphorbol Acetate 33-36 interleukin 6 Homo sapiens 116-120 3494671-1 1987 The effect of a B-cell differentiation factor (BCDF) found in the supernatant of the human bladder carcinoma cell line T-24 (T-24.BCDF) was assessed using the human lymphoblastoid line CESS (Muraguchi et al., 1981) and TPA-stimulated human B-CLL B cells. Tetradecanoylphorbol Acetate 219-222 interleukin 6 Homo sapiens 16-45 3494671-1 1987 The effect of a B-cell differentiation factor (BCDF) found in the supernatant of the human bladder carcinoma cell line T-24 (T-24.BCDF) was assessed using the human lymphoblastoid line CESS (Muraguchi et al., 1981) and TPA-stimulated human B-CLL B cells. Tetradecanoylphorbol Acetate 219-222 interleukin 6 Homo sapiens 47-51 32289862-0 2020 Heparanase Facilitates PMA-Induced Megakaryocytic Differentiation in K562 Cells via Interleukin 6/STAT3 Pathway. Tetradecanoylphorbol Acetate 23-26 interleukin 6 Homo sapiens 84-97 30919561-4 2019 In this study, it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells. Tetradecanoylphorbol Acetate 95-98 interleukin 6 Homo sapiens 108-112 30919561-4 2019 In this study, it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells. Tetradecanoylphorbol Acetate 95-98 interleukin 6 Homo sapiens 135-139 27104574-3 2016 Their ability to induce the production of cytokines TNFalpha, IL-1beta and IL-6 in phorbol-12-myristate-13-acetate (PMA)-treated U937 cells was assessed. Tetradecanoylphorbol Acetate 83-114 interleukin 6 Homo sapiens 75-79 27598116-5 2016 IL-6 levels in the HMC-1 stimulated by phorbol-12-myristate-13-acetate and A23187 were apparently decreased by the treatment of atractylodin. Tetradecanoylphorbol Acetate 39-70 interleukin 6 Homo sapiens 0-4 31070650-6 2019 Furthermore, TPA obviously assuaged TNF-alpha-evoked up-regulation of IL-8 and IL-6 expression, down-regulation of occludin and ZO-3 expression, and markedly suppressed the activation and protein expression of NF-kappaB p65. Tetradecanoylphorbol Acetate 13-16 interleukin 6 Homo sapiens 79-83 30226556-9 2018 The in vitro experiments demonstrated that NGE reduced the phorbol 12-myristate 13-acetate + ionomycin-induced expression of pro-inflammatory cytokines interleukin (IL)-4, IL-13, tumor necrosis factor-alpha, and IL-6 in HMC-1 cells. Tetradecanoylphorbol Acetate 59-90 interleukin 6 Homo sapiens 212-216 30154906-6 2018 Furthermore, KJS018A diminished the effect of PMA, an inflammatory inducer via IL-6/STAT3/Cox-2 pathway. Tetradecanoylphorbol Acetate 46-49 interleukin 6 Homo sapiens 79-83 28276734-5 2017 In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells. Tetradecanoylphorbol Acetate 149-174 interleukin 6 Homo sapiens 141-145 28276734-5 2017 In addition, we also showed that 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7 cells. Tetradecanoylphorbol Acetate 176-179 interleukin 6 Homo sapiens 141-145 27871911-5 2017 In addition, we also showed that theaflavin-3,3"-digallate inhibited the expression of tumor necrosis factor alpha, interleukin -1 beta, and interleukin 6 in phorbol myristate acetate -primed U937 and RAW 264.7 cells. Tetradecanoylphorbol Acetate 158-183 interleukin 6 Homo sapiens 141-154 27138049-3 2016 The assay employed a model of the human monocyte cell line U937 stimulated with lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate (PMA) for the release of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6. Tetradecanoylphorbol Acetate 109-140 interleukin 6 Homo sapiens 204-222 27104574-3 2016 Their ability to induce the production of cytokines TNFalpha, IL-1beta and IL-6 in phorbol-12-myristate-13-acetate (PMA)-treated U937 cells was assessed. Tetradecanoylphorbol Acetate 116-119 interleukin 6 Homo sapiens 75-79 26718326-5 2016 We noted that the purified nonameric peptide (AIGIDP) attenuated the phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-induced histamine release and the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and IL-6 in human mast cells (HMC-1 cells). Tetradecanoylphorbol Acetate 69-100 interleukin 6 Homo sapiens 291-295 25933972-6 2015 Here, we investigated the precise mechanism by which LU8C-FP inhibited phorbol 12-myristate 13-acetate-induced IL-6 mRNA and protein expression. Tetradecanoylphorbol Acetate 71-102 interleukin 6 Homo sapiens 111-115 26573554-7 2016 In human mast cells, sesamin reduced the stimulatory effects of phorbol 12-myristate 13-acetate and calcium ionophore A23187 on the production and secretion of pro-inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-6. Tetradecanoylphorbol Acetate 64-95 interleukin 6 Homo sapiens 230-243 24877691-6 2014 ZO-NP was found to inhibit the productions and mRNA expressions of inflammatory cytokines such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha on the phorbol 12-myristate 13-acetate plus A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells. Tetradecanoylphorbol Acetate 167-198 interleukin 6 Homo sapiens 122-159 25973018-12 2015 BCG induced HMGB1, IL-6, IL-10 and TNF-alpha production effectively in PMA-treated THP-1 cells. Tetradecanoylphorbol Acetate 71-74 interleukin 6 Homo sapiens 19-23 24589569-5 2014 TET significantly inhibited the induction of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 by phorbol 12-myristate 13-acetate (PMA) plus A23187. Tetradecanoylphorbol Acetate 143-174 interleukin 6 Homo sapiens 111-129 24951586-4 2014 First, silencing ASM with siRNA abrogated IL-6 production in response to the tumor promoter, 4beta-phorbol 12-myristate 13-acetate (PMA), in MCF-7 cells, in distinction to acid beta-glucosidase 1 and acid ceramidase, suggesting specialization of the pathways. Tetradecanoylphorbol Acetate 132-135 interleukin 6 Homo sapiens 42-46 24951586-4 2014 First, silencing ASM with siRNA abrogated IL-6 production in response to the tumor promoter, 4beta-phorbol 12-myristate 13-acetate (PMA), in MCF-7 cells, in distinction to acid beta-glucosidase 1 and acid ceramidase, suggesting specialization of the pathways. Tetradecanoylphorbol Acetate 93-130 interleukin 6 Homo sapiens 42-46 22351517-6 2013 TPA treatment also elevates levels of c-jun (AP-1 component), cyclooxygenase-2 (COX-2), p50 (NF-kappaB component), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in the skin. Tetradecanoylphorbol Acetate 0-3 interleukin 6 Homo sapiens 115-128 23764888-5 2013 Arazyme inhibited the secretion of IL-6 and IL-8 due to phorbol 12-myristate 13-acetate and calcium ionophores in human mast cells. Tetradecanoylphorbol Acetate 56-87 interleukin 6 Homo sapiens 35-39 22351517-6 2013 TPA treatment also elevates levels of c-jun (AP-1 component), cyclooxygenase-2 (COX-2), p50 (NF-kappaB component), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in the skin. Tetradecanoylphorbol Acetate 0-3 interleukin 6 Homo sapiens 130-134 22445541-3 2012 Here, we showed that staphylococcal LTA (Sa.LTA) substantially enhanced IL-6 expression at both the protein and the mRNA levels in the human basophil line, KU812, in the presence of a PKC activator (phorbol 12-myristrate 13-acetate; PMA), and a calcium ionophore (A23187), whereas Sa.LTA alone could not induce IL-6 expression. Tetradecanoylphorbol Acetate 233-236 interleukin 6 Homo sapiens 72-76 23806369-8 2013 With knockdown of LSD1, H3K4 methylation at IL-6 promoter was found increased after TPA treatment at different times points (all P<0.05, except 24 hours). Tetradecanoylphorbol Acetate 84-87 interleukin 6 Homo sapiens 44-48 23488631-3 2013 SI, AD, and DM reduced a mean phorbol-12-myristate-13-acetate/ionomycin (PMA/I)-stimulated release of the pro-inflammatory interleukins IL-6 and IL-8 by more than 50% (p < 0.05). Tetradecanoylphorbol Acetate 30-61 interleukin 6 Homo sapiens 136-140 22927445-4 2012 We show that phorbol 12-myristate 13-acetate (PMA)-induced increase in IL-6 production by IL-32alpha-expressing cells was higher than that by empty vector-expressing cells and that this increase occurred in a time- and dose-dependent manner. Tetradecanoylphorbol Acetate 13-44 interleukin 6 Homo sapiens 71-75 22927445-4 2012 We show that phorbol 12-myristate 13-acetate (PMA)-induced increase in IL-6 production by IL-32alpha-expressing cells was higher than that by empty vector-expressing cells and that this increase occurred in a time- and dose-dependent manner. Tetradecanoylphorbol Acetate 46-49 interleukin 6 Homo sapiens 71-75 22696070-0 2012 Enhancement of protease-induced IL-6 release in monocytic U-937 cells by phorbol-12-myristate-13-acetate. Tetradecanoylphorbol Acetate 73-104 interleukin 6 Homo sapiens 32-36 22696070-1 2012 OBJECTIVE AND DESIGN: Serine proteases and phorbol-12-myristate-13-acetate (PMA) are able to induce the release of pro-inflammatory interleukin-6 (IL-6) in monocytic cells. Tetradecanoylphorbol Acetate 43-74 interleukin 6 Homo sapiens 147-151 22696070-1 2012 OBJECTIVE AND DESIGN: Serine proteases and phorbol-12-myristate-13-acetate (PMA) are able to induce the release of pro-inflammatory interleukin-6 (IL-6) in monocytic cells. Tetradecanoylphorbol Acetate 76-79 interleukin 6 Homo sapiens 147-151 21771721-5 2011 12-O-tetradecanoylphorbol 13-acetate-induced differentiation of human U937 monocytes increased the expression and secretion of inflammatory cytokines such as tumor necrosis factor alpha, interleukin (IL)-6 and IL-8. Tetradecanoylphorbol Acetate 0-36 interleukin 6 Homo sapiens 187-205 21142820-5 2011 Apigenin significantly inhibits the inductive effect of phorbol 12-myristate 13-acetate (PMA) plus A23187 on the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF). Tetradecanoylphorbol Acetate 56-87 interleukin 6 Homo sapiens 213-217 21555360-7 2011 Finally, we have shown that lipoxin A(4) can suppress phorbol myristate acetate-induced expression of the inflammatory cytokines interleukin 6 and 8 in human endometrium and decidua tissue. Tetradecanoylphorbol Acetate 54-79 interleukin 6 Homo sapiens 129-148 20604677-4 2011 The results indicated that beta-eudesmol inhibited the production and expression of interleukin (IL)-6 on phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated human mast cell (HMC). Tetradecanoylphorbol Acetate 106-137 interleukin 6 Homo sapiens 84-102 21302967-3 2011 This sesquiterpenoid inhibited the secretion and expression of IL-6 in phorbol 12-myristate 13-acetate- and calcium ionophore A23187-stimulated human mast cells (HMC)-1. Tetradecanoylphorbol Acetate 71-102 interleukin 6 Homo sapiens 63-67 21165548-3 2011 In the present study, we demonstrate that artemisinin inhibits the secretion and the mRNA levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1ss, and IL-6 in a dose-dependent manner in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 human monocytes. Tetradecanoylphorbol Acetate 196-227 interleukin 6 Homo sapiens 161-165 20953574-5 2011 Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1. Tetradecanoylphorbol Acetate 95-126 interleukin 6 Homo sapiens 230-234 20953574-5 2011 Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1. Tetradecanoylphorbol Acetate 128-131 interleukin 6 Homo sapiens 230-234 20953574-9 2011 In Rab7b-silenced cells, PMA-induced activation of NF-kappaB, IL-6 production, and megakaryocytic differentiation are impaired. Tetradecanoylphorbol Acetate 25-28 interleukin 6 Homo sapiens 62-66 19789931-7 2010 Moreover, AAS significantly inhibited production of inflammatory cytokines, tumor necrosis factor (TNF), interleukin (IL)-6, and IL-8 on the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated human mast cell line, HMC-1 cells. Tetradecanoylphorbol Acetate 141-172 interleukin 6 Homo sapiens 105-123 21628878-2 2011 SA significantly inhibited phorbol myristate acetate (PMA) plus A23187-induced the production and expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in human mast cell (HMC)-1 cells. Tetradecanoylphorbol Acetate 27-52 interleukin 6 Homo sapiens 112-130 21628878-2 2011 SA significantly inhibited phorbol myristate acetate (PMA) plus A23187-induced the production and expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in human mast cell (HMC)-1 cells. Tetradecanoylphorbol Acetate 54-57 interleukin 6 Homo sapiens 112-130 20463301-8 2010 In addition, WECG attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187-stimulated gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6 in human mast cells. Tetradecanoylphorbol Acetate 33-64 interleukin 6 Homo sapiens 204-217 20164300-5 2010 Our results showed that butrin, isobutrin, and butein significantly reduced the phorbol 12-myristate 13-acetate and calcium ionophore A23187-induced inflammatory gene expression and production of TNF-alpha, IL-6, and IL-8 in HMC-1 cells by inhibiting the activation of NF-kappaB. Tetradecanoylphorbol Acetate 80-111 interleukin 6 Homo sapiens 207-211 20512034-11 2010 Phosphorylation levels induced by interleukin-6 in STAT1 and STAT3 and by combination of phorbol 12-myristate 13-acetate and calcium ionophore A23187 in extracellular signal-regulated kinases 1/2, members of a mitogen-activated protein kinase family, were depressed in patients" monocytes, whereas phosphorylation levels induced by granulocyte-macrophage colony-stimulating factor in STAT5 was normal. Tetradecanoylphorbol Acetate 89-120 interleukin 6 Homo sapiens 34-47 19907654-4 2009 We provide evidence for decreased DNA fragmentation, reduced mitochondrial membrane depolarization, impaired reactive oxygen species production, diminished cytochrome c release and increased IL-6 production compared to healthy subjects after PMA exposure. Tetradecanoylphorbol Acetate 242-245 interleukin 6 Homo sapiens 191-195 20110595-5 2010 Basal and PMA-stimulated levels of IFN-gamma, TNF-alpha, and IL-6 were measured by ELISPOT (PBMC culture supernatant). Tetradecanoylphorbol Acetate 10-13 interleukin 6 Homo sapiens 61-65 19279008-5 2009 Knockdown of GBA1 also evoked the hyperproduction of IL-6 in response to 4beta phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 73-110 interleukin 6 Homo sapiens 53-57 19416633-6 2009 Resveratrol significantly inhibited the PMA plus A23187-induction of inflammatory cytokines such as tumour necrosis factor (TNF)-alpha, interleukin (IL)-6 and IL-8. Tetradecanoylphorbol Acetate 40-43 interleukin 6 Homo sapiens 136-154 18954528-4 2008 The deregulation of 17AAG and phorbol 12-myristate 13-acetate (PMA) on the IL-6 gene was determined by ELISA and transient gene expression assays using an IL-6 reporter vector. Tetradecanoylphorbol Acetate 30-61 interleukin 6 Homo sapiens 75-79 18954528-4 2008 The deregulation of 17AAG and phorbol 12-myristate 13-acetate (PMA) on the IL-6 gene was determined by ELISA and transient gene expression assays using an IL-6 reporter vector. Tetradecanoylphorbol Acetate 63-66 interleukin 6 Homo sapiens 75-79 18954528-4 2008 The deregulation of 17AAG and phorbol 12-myristate 13-acetate (PMA) on the IL-6 gene was determined by ELISA and transient gene expression assays using an IL-6 reporter vector. Tetradecanoylphorbol Acetate 63-66 interleukin 6 Homo sapiens 155-159 18222974-9 2008 In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells. Tetradecanoylphorbol Acetate 33-64 interleukin 6 Homo sapiens 155-168 18222974-9 2008 In addition, MEVA attenuated the phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-stimulated secretion of tumor necrosis factor-alpha, interleukin-6 (IL-6), and IL-8 in human mast cells. Tetradecanoylphorbol Acetate 33-64 interleukin 6 Homo sapiens 170-174 17609508-4 2007 In addition, PVAE attenuated phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-6, and IL-8 secretion in human mast cells. Tetradecanoylphorbol Acetate 29-60 interleukin 6 Homo sapiens 118-122 17321112-9 2007 Protein kinase C (PKC) activation by phorbol myristate acetate (PMA) potentiated IL-6 mRNA expression, whereas PKC inhibition by bisindolylmaleimide blocked SPC-induced p42/44 ERK phosphorylation and IL-6 expression. Tetradecanoylphorbol Acetate 37-62 interleukin 6 Homo sapiens 81-85 17321112-9 2007 Protein kinase C (PKC) activation by phorbol myristate acetate (PMA) potentiated IL-6 mRNA expression, whereas PKC inhibition by bisindolylmaleimide blocked SPC-induced p42/44 ERK phosphorylation and IL-6 expression. Tetradecanoylphorbol Acetate 64-67 interleukin 6 Homo sapiens 81-85 17094021-5 2007 DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 106-137 interleukin 6 Homo sapiens 98-102 17049124-5 2006 RESULTS: The peptide has the ability to interact with the NF-kappaB p50 subunit and can effectively inhibit TNF-alpha and IL-6 production in the THP-1 cell line, PMA-induced ear edema and zymosan A-induced peritonitis in mice. Tetradecanoylphorbol Acetate 162-165 interleukin 6 Homo sapiens 122-126 17094021-5 2007 DA-9601 dose-dependently decreased the gene expression and production of TNF-alpha, IL-1beta, and IL-6 on phorbol 12-myristate 13-acetate (PMA)- and calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 139-142 interleukin 6 Homo sapiens 98-102 17113069-4 2007 Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P<0.05). Tetradecanoylphorbol Acetate 72-103 interleukin 6 Homo sapiens 214-232 17113069-4 2007 Scopoletin significantly and dose-dependently inhibits the way in which phorbol 12-myristate 13-acetate (PMA) plus A23187 induces the production of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 (P<0.05). Tetradecanoylphorbol Acetate 105-108 interleukin 6 Homo sapiens 214-232 17079162-4 2007 Fisetin decreased phorbol-12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated gene expression and production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-4, IL-6, and IL-8 in HMC-1 cells. Tetradecanoylphorbol Acetate 18-49 interleukin 6 Homo sapiens 204-208 16574371-4 2006 FPT dose dependently decreased the gene expression and production of TNF-alpha and IL-6 on phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 91-122 interleukin 6 Homo sapiens 83-87 16890260-8 2006 Furthermore, AEMD attenuated the phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated TNF-alpha, IL-8 and IL-6 secretion in human mast cells. Tetradecanoylphorbol Acetate 33-64 interleukin 6 Homo sapiens 131-135 16574371-4 2006 FPT dose dependently decreased the gene expression and production of TNF-alpha and IL-6 on phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 124-127 interleukin 6 Homo sapiens 83-87 16322071-6 2006 Gallic acid decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated pro-inflammatory cytokine gene expression and production such as TNF-alpha and IL-6 in human mast cells. Tetradecanoylphorbol Acetate 26-57 interleukin 6 Homo sapiens 178-182 16562828-1 2006 Crude extracts of Witheringia solanacea leaves showed inhibition of NF-kappaB activation at 100 microg/mL induced by phorbol 12-myristate-13-acetate (PMA) in HeLa cells stably transfected with a luciferase reporter gene controlled by the IL-6 promoter. Tetradecanoylphorbol Acetate 150-153 interleukin 6 Homo sapiens 238-242 16997791-7 2006 Furthermore, AIAE attenuated the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 secretion in human mast cells. Tetradecanoylphorbol Acetate 33-64 interleukin 6 Homo sapiens 138-151 16275618-7 2005 Furthermore, GRJ decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated TNF-alpha and IL-6 secretion in human mast cells. Tetradecanoylphorbol Acetate 31-62 interleukin 6 Homo sapiens 118-122 16357489-12 2006 In addition, DAAE decreased TNF-alpha and IL-6 gene expression and production in human mast cells stimulated by phorbol-12-myristate-13-acetate (PMA) plus calcium ionophore A23187. Tetradecanoylphorbol Acetate 112-143 interleukin 6 Homo sapiens 42-46 16357489-12 2006 In addition, DAAE decreased TNF-alpha and IL-6 gene expression and production in human mast cells stimulated by phorbol-12-myristate-13-acetate (PMA) plus calcium ionophore A23187. Tetradecanoylphorbol Acetate 145-148 interleukin 6 Homo sapiens 42-46 15936049-10 2005 Furthermore, LAE decreased the secretion of TNF-alpha and IL-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cells. Tetradecanoylphorbol Acetate 66-97 interleukin 6 Homo sapiens 58-62 15936049-10 2005 Furthermore, LAE decreased the secretion of TNF-alpha and IL-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cells. Tetradecanoylphorbol Acetate 99-102 interleukin 6 Homo sapiens 58-62 16179737-6 2005 Furthermore, AXE attenuated the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore (A23187)-stimulated tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 secretion in human mast cells. Tetradecanoylphorbol Acetate 32-63 interleukin 6 Homo sapiens 157-175 16179737-6 2005 Furthermore, AXE attenuated the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore (A23187)-stimulated tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 secretion in human mast cells. Tetradecanoylphorbol Acetate 65-68 interleukin 6 Homo sapiens 157-175 15618130-9 2005 Furthermore, AIE decreased the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 gene expression and production in human mast cells. Tetradecanoylphorbol Acetate 64-67 interleukin 6 Homo sapiens 142-155 15946602-12 2005 In addition, GBIT extract inhibited phorbol 12-myristate 13-acetate + A23187-induced interleukin-6 secretion from human mast cell line HMC-1 cells. Tetradecanoylphorbol Acetate 36-67 interleukin 6 Homo sapiens 85-98 15652280-5 2005 When CYSST (1mg/ml) was added, the production of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8 was significantly inhibited about 37, 33.6, and 48%, respectively on phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 176-207 interleukin 6 Homo sapiens 78-96 15618130-9 2005 Furthermore, AIE decreased the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor-alpha and interleukin-6 gene expression and production in human mast cells. Tetradecanoylphorbol Acetate 31-62 interleukin 6 Homo sapiens 142-155 15625014-3 2004 In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect. Tetradecanoylphorbol Acetate 192-228 interleukin 6 Homo sapiens 39-52 15625014-3 2004 In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect. Tetradecanoylphorbol Acetate 192-228 interleukin 6 Homo sapiens 54-58 15625014-3 2004 In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect. Tetradecanoylphorbol Acetate 230-233 interleukin 6 Homo sapiens 39-52 19180800-4 2003 Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively. Tetradecanoylphorbol Acetate 39-70 interleukin 6 Homo sapiens 180-184 15625014-3 2004 In K562 leukemia cells, treatment with interleukin-6 (IL-6) or granulocyte-macrophage colony stimulating factor (GM-CSF) reduced the proportion of the Bcl-xL variant mRNA while treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) had no effect. Tetradecanoylphorbol Acetate 230-233 interleukin 6 Homo sapiens 54-58 15654514-4 2004 RESULTS: HMC-1 produced substantial amounts of GM-CSF and IL-8 and smaller amounts of TNF-alpha, IL-4 and IL-6 after being stimulated with PMA together with A23187. Tetradecanoylphorbol Acetate 139-142 interleukin 6 Homo sapiens 106-110 15209363-6 2004 IJAE inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cell line (HMC-1) cells. Tetradecanoylphorbol Acetate 98-129 interleukin 6 Homo sapiens 76-94 19180800-4 2003 Purple bamboo salt (1 mg/mL) inhibited phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 secretion, by 67.04% +/- 0.08%, 68.01% +/- 1.85%, and 69.48% +/- 0.54%, respectively. Tetradecanoylphorbol Acetate 72-75 interleukin 6 Homo sapiens 180-184 12748876-4 2003 In addition, granulosa cells obtained from the follicular fluid were cultured and treated with forskolin and 12- o-tetradecanoylphorbol 13-acetate for 24-48 h. The concentration of IL-6 was significantly higher in the follicular fluid than in the serum (P<0.01). Tetradecanoylphorbol Acetate 109-146 interleukin 6 Homo sapiens 181-185 12576215-6 2003 When DGHT (1mg/ml) was added, the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 was inhibited by 60.1, 81.8, 72.5%, respectively in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 166-197 interleukin 6 Homo sapiens 109-113 12626585-3 2003 Pretreatment of macrophages with PMA or the proinflammatory mediators LPS and TNF-alpha blocks IL-6-induced STAT3 activation, whereas IL-10-induced activation of STAT3 remains largely unaffected. Tetradecanoylphorbol Acetate 33-36 interleukin 6 Homo sapiens 95-99 12576215-6 2003 When DGHT (1mg/ml) was added, the secretion of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-6 was inhibited by 60.1, 81.8, 72.5%, respectively in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 199-202 interleukin 6 Homo sapiens 109-113 11884403-4 2002 Phorbol myristate acetate induced a dramatic increase of both IL-6R shedding (i.e. the production of sIL-6R) and IL-6 release in osteoblast cultures, but the cell surface expression of gp130 remained unchanged. Tetradecanoylphorbol Acetate 0-25 interleukin 6 Homo sapiens 62-66 12675201-8 2003 In addition, PUAE (0.1 and 1 mg/mL) inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 126-157 interleukin 6 Homo sapiens 104-122 12675201-8 2003 In addition, PUAE (0.1 and 1 mg/mL) inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated HMC-1 cells. Tetradecanoylphorbol Acetate 159-162 interleukin 6 Homo sapiens 104-122 12452835-6 2002 In the A549 cells, gp-340 was up-regulated along with the PMA-induced proinflammatory expression of both IL-6 and IL-8. Tetradecanoylphorbol Acetate 58-61 interleukin 6 Homo sapiens 105-109 12023021-4 2002 By prednisolone or phorbol myristate acetate treatment, EC-SOD levels were correlated negatively with levels of IL-6 and IL-8. Tetradecanoylphorbol Acetate 19-44 interleukin 6 Homo sapiens 112-116