PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 13679379-0 2003 Multiple cis-elements mediate the transcriptional activation of human fra-1 by 12-O-tetradecanoylphorbol-13-acetate in bronchial epithelial cells. Tetradecanoylphorbol Acetate 79-115 FOS like 1, AP-1 transcription factor subunit Homo sapiens 70-75 18435914-3 2008 We have previously shown that two critical elements of Fra-1 promoter, the upstream TPA response element (TRE) and the serum response element (SRE), are necessary for its induction in response to phorbol esters in human pulmonary epithelial cell lines. Tetradecanoylphorbol Acetate 84-87 FOS like 1, AP-1 transcription factor subunit Homo sapiens 55-60 18435914-4 2008 Here, we have investigated the roles of various MAP kinases in regulating Fra-1 expression in response to TPA. Tetradecanoylphorbol Acetate 106-109 FOS like 1, AP-1 transcription factor subunit Homo sapiens 74-79 17082637-3 2006 In this study, we report that TNF-alpha stimulates the expression of the FRA-1 protooncogene in human pulmonary epithelial cells using c-Jun, acting via a 12-O-tetradecanoylphorbol-13 acetate response element located at -318. Tetradecanoylphorbol Acetate 155-191 FOS like 1, AP-1 transcription factor subunit Homo sapiens 73-78 15806162-0 2005 Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements. Tetradecanoylphorbol Acetate 121-124 FOS like 1, AP-1 transcription factor subunit Homo sapiens 31-36 15806162-4 2005 Our recent analysis of the FRA-1 promoter has shown a critical role for a TRE located at -318 in mediating the TPA-induced expression. Tetradecanoylphorbol Acetate 111-114 FOS like 1, AP-1 transcription factor subunit Homo sapiens 27-32 15806162-6 2005 Here, we show that a 40-bp (-276/-237) segment, comprising a TCF binding site and the CArG box (collectively known as serum response element, SRE), and an ATF site, is also necessary for the FRA-1 induction by TPA and EGF. Tetradecanoylphorbol Acetate 210-213 FOS like 1, AP-1 transcription factor subunit Homo sapiens 191-196 15806162-11 2005 RNAi-mediated knockdown of endogenous SRF, ELK1 and c-JUN protein expression significantly reduced TPA-stimulated FRA-1 promoter activity. Tetradecanoylphorbol Acetate 99-102 FOS like 1, AP-1 transcription factor subunit Homo sapiens 114-119 15790882-10 2005 Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased AP1 factor (Fra-1 and JunB) binding to the hINV gene AP1-5 response element. Tetradecanoylphorbol Acetate 15-51 FOS like 1, AP-1 transcription factor subunit Homo sapiens 175-180 15790882-10 2005 Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a protein kinase C activator, increased hINV gene expression, a response that correlates with increased AP1 factor (Fra-1 and JunB) binding to the hINV gene AP1-5 response element. Tetradecanoylphorbol Acetate 53-56 FOS like 1, AP-1 transcription factor subunit Homo sapiens 175-180 13679379-3 2003 In contrast to a transient induction by H2O2, TPA persistently activated fra-1 transcription, principally at the transcriptional level. Tetradecanoylphorbol Acetate 46-49 FOS like 1, AP-1 transcription factor subunit Homo sapiens 73-78 13679379-7 2003 Thus, cooperative interactions between factors binding to multiple cis-elements of the -379/-283 promoter region appear to regulate TPA-induced fra-1 transcription in HBE cells. Tetradecanoylphorbol Acetate 132-135 FOS like 1, AP-1 transcription factor subunit Homo sapiens 144-149 13679379-11 2003 Chromatin immunoprecipitation assays revealed an enhanced recruitment of c-Jun, Jun-D, and Fra-2 to the endogenous fra-1 promoter upon TPA stimulation. Tetradecanoylphorbol Acetate 135-138 FOS like 1, AP-1 transcription factor subunit Homo sapiens 115-120 13679379-12 2003 These results underscore the regulatory role of c-Jun, Jun-D, and Fra-2 in TPA-inducible fra-1 expression in HBE cells in vivo. Tetradecanoylphorbol Acetate 75-78 FOS like 1, AP-1 transcription factor subunit Homo sapiens 89-94 13679379-2 2003 Here, we have investigated the transcriptional regulation of fra-1 by 12-O-tetradecanoylphorbol-13-acetate (TPA) in human bronchial epithelial (HBE) cells, which are the direct targets of inhaled toxins/carcinogens. Tetradecanoylphorbol Acetate 70-106 FOS like 1, AP-1 transcription factor subunit Homo sapiens 61-66 13679379-2 2003 Here, we have investigated the transcriptional regulation of fra-1 by 12-O-tetradecanoylphorbol-13-acetate (TPA) in human bronchial epithelial (HBE) cells, which are the direct targets of inhaled toxins/carcinogens. Tetradecanoylphorbol Acetate 108-111 FOS like 1, AP-1 transcription factor subunit Homo sapiens 61-66 11756554-8 2002 Fra-1 was activated by TPA in ERK-sufficient P(+) cells but not in ERK-deficient P(-) cells. Tetradecanoylphorbol Acetate 23-26 FOS like 1, AP-1 transcription factor subunit Homo sapiens 0-5 12682075-2 2003 Previously, we have shown that the transcriptional stimulation of SPRR1B expression by phorbol 12-myristate 13-acetate (PMA) is mainly mediated by a -150/-94 bp enhancer harboring two critical 12-O-tetradecanoylphorbol-13-acetate-responsive elements (TREs) and by Jun.Fra-1 dimers. Tetradecanoylphorbol Acetate 87-118 FOS like 1, AP-1 transcription factor subunit Homo sapiens 268-273 12682075-2 2003 Previously, we have shown that the transcriptional stimulation of SPRR1B expression by phorbol 12-myristate 13-acetate (PMA) is mainly mediated by a -150/-94 bp enhancer harboring two critical 12-O-tetradecanoylphorbol-13-acetate-responsive elements (TREs) and by Jun.Fra-1 dimers. Tetradecanoylphorbol Acetate 120-123 FOS like 1, AP-1 transcription factor subunit Homo sapiens 268-273 11948401-9 2002 The transcriptional activities of full-length JunB and full-length Fra-1, but not the transactivation domain fusions, were increased by TPA treatment and suppressed by RA. Tetradecanoylphorbol Acetate 136-139 FOS like 1, AP-1 transcription factor subunit Homo sapiens 67-72 8389757-8 1993 Other studies further demonstrate that the jun-B and fra-1 genes are induced by TPA in both HL-60/vinc and HL-60/vinc/R cells, whereas c-fos expression is attenuated in the HL-60/vinc line. Tetradecanoylphorbol Acetate 80-83 FOS like 1, AP-1 transcription factor subunit Homo sapiens 53-58 7761434-8 1995 Furthermore, Fra-1 repressed AP-1 activity induced by either TPA or expression of c-Jun and c-Fos. Tetradecanoylphorbol Acetate 61-64 FOS like 1, AP-1 transcription factor subunit Homo sapiens 13-18 7761434-9 1995 We therefore conclude that inhibitory AP-1 complexes composed of Jun-Fra heterodimers, induced by BHQ, antagonize the transcriptional effects of the tumor promoter TPA, which are mediated by Jun-Fos heterodimers. Tetradecanoylphorbol Acetate 164-167 FOS like 1, AP-1 transcription factor subunit Homo sapiens 69-72 1445622-0 1992 12-O-tetradecanoylphorbol-13-acetate--induced levels of AP-1 proteins: a 46-kDa protein immunoprecipitated by anti-fra-1 and induced in promotion-resistant but not promotion-sensitive JB6 cells. Tetradecanoylphorbol Acetate 0-36 FOS like 1, AP-1 transcription factor subunit Homo sapiens 115-120 1445622-5 1992 Whereas the AP-1 proteins junB, junD, and fosB did not show differential basal or TPA-inducible levels in P+ and P- cells, a 46-kDa species precipitated by anti-fra-1 antibody was TPA-inducible in P- cells but not in P+ cells, and c-jun protein was present at higher levels in TPA-treated and untreated P+ cells than in P- cells. Tetradecanoylphorbol Acetate 180-183 FOS like 1, AP-1 transcription factor subunit Homo sapiens 161-166 1445622-5 1992 Whereas the AP-1 proteins junB, junD, and fosB did not show differential basal or TPA-inducible levels in P+ and P- cells, a 46-kDa species precipitated by anti-fra-1 antibody was TPA-inducible in P- cells but not in P+ cells, and c-jun protein was present at higher levels in TPA-treated and untreated P+ cells than in P- cells. Tetradecanoylphorbol Acetate 180-183 FOS like 1, AP-1 transcription factor subunit Homo sapiens 161-166 2107490-6 1990 Transcription of the fos, fra-1 and fra-2 genes was induced by phorbol ester (TPA) stimulation of U937 human monocytic cells. Tetradecanoylphorbol Acetate 78-81 FOS like 1, AP-1 transcription factor subunit Homo sapiens 26-31 2107490-7 1990 On TPA stimulation, the transcriptions of fos, fra-1 and fra-2 were detectable after 30, 60 and 120 min and maximum after 60, 90 and 240 min, respectively. Tetradecanoylphorbol Acetate 3-6 FOS like 1, AP-1 transcription factor subunit Homo sapiens 47-52