PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11463743-3 2001 We identified the novel KRE-M9 element, further downstream to the previously reported TPA responsive element in the MMP-9 promoter, and both of these two elements were shown to be important for MMP-9 transcription and Ca(2+) induction. Tetradecanoylphorbol Acetate 86-89 matrix metallopeptidase 9 Homo sapiens 116-121 11463743-3 2001 We identified the novel KRE-M9 element, further downstream to the previously reported TPA responsive element in the MMP-9 promoter, and both of these two elements were shown to be important for MMP-9 transcription and Ca(2+) induction. Tetradecanoylphorbol Acetate 86-89 matrix metallopeptidase 9 Homo sapiens 194-199 11368535-8 2001 TPA and Vitrogen resulted in up-regulation of MMP-9 in each of the cell lines, while Con-A could up-regulate MMP-9 expression only in SUIT-2. Tetradecanoylphorbol Acetate 0-3 matrix metallopeptidase 9 Homo sapiens 46-51 11368535-11 2001 CONCLUSION: These data suggest that, while MMP-2 and MMP-9 are not constitutively expressed in pancreatic carcinoma cell lines, they may be up-regulated by TPA, Con-A, and Vitrogen. Tetradecanoylphorbol Acetate 156-159 matrix metallopeptidase 9 Homo sapiens 53-58 11487146-7 2001 The present results suggested that TNF-alpha stimulates PA activity via an enhancement of tPA gene expression in HDP cells and MMP-2 activity, and further that tPA-activated TNF-alpha stimulated MMP-9. Tetradecanoylphorbol Acetate 160-163 matrix metallopeptidase 9 Homo sapiens 195-200 11299737-5 2001 TPA increased the MMP-9 production by T24 cells without altering expression of TIMP-1 gene, while NAC suppressed TPA-enhanced production of MMP-9. Tetradecanoylphorbol Acetate 0-3 matrix metallopeptidase 9 Homo sapiens 18-23 11299737-5 2001 TPA increased the MMP-9 production by T24 cells without altering expression of TIMP-1 gene, while NAC suppressed TPA-enhanced production of MMP-9. Tetradecanoylphorbol Acetate 113-116 matrix metallopeptidase 9 Homo sapiens 140-145 10936484-6 2000 Troglitazone, rosiglitazone, or AGN 4204 inhibited phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 expression. Tetradecanoylphorbol Acetate 51-82 matrix metallopeptidase 9 Homo sapiens 97-123 10936484-6 2000 Troglitazone, rosiglitazone, or AGN 4204 inhibited phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 expression. Tetradecanoylphorbol Acetate 84-87 matrix metallopeptidase 9 Homo sapiens 97-123 11315098-4 2000 In addition, conditioned medium collected from SNB19 cells transfected with these expression vectors showed diminished MMP-9 activity in the presence of phorbol myristate acetate, as determined by gelatin zymography. Tetradecanoylphorbol Acetate 153-178 matrix metallopeptidase 9 Homo sapiens 119-124 11448065-2 2000 Unstimulated cocultures did not form capillaries and produce MMP-9 but stimulation with the protein kinase C (PKC) activator 4-phorbol-12-myristate 13-acetate (PMA) produced MMP-9 and capillary networks. Tetradecanoylphorbol Acetate 160-163 matrix metallopeptidase 9 Homo sapiens 174-179 11448065-6 2000 Finally, PMA-induced MMP-9 expression and capillary formation were inhibited by the MEKK-specific inhibitor PD98059. Tetradecanoylphorbol Acetate 9-12 matrix metallopeptidase 9 Homo sapiens 21-26 10458779-5 1999 Cultured mast cells and HMC-1 cells treated with phorbol 12-myristate 13-acetate were shown to express MMP9 mRNA, and the cultured conditioned media from these cells showed gelatinolytic activity, identical with MMP9. Tetradecanoylphorbol Acetate 49-80 matrix metallopeptidase 9 Homo sapiens 103-107 10458779-5 1999 Cultured mast cells and HMC-1 cells treated with phorbol 12-myristate 13-acetate were shown to express MMP9 mRNA, and the cultured conditioned media from these cells showed gelatinolytic activity, identical with MMP9. Tetradecanoylphorbol Acetate 49-80 matrix metallopeptidase 9 Homo sapiens 212-216 10329260-5 1999 Phorbol myristate acetate, known to induce protease activity in other endothelial cell populations, stimulated MMP1, MMP9, and TIMP1 secretion in both NDEC and PEDEC. Tetradecanoylphorbol Acetate 0-25 matrix metallopeptidase 9 Homo sapiens 117-121 9873009-2 1999 In this study, we show that the secretion of matrix metalloproteinase-9 (MMP-9) from HT 1080 human fibrosarcoma cells was stimulated by phorbol 12-myristate 13-acetate in a time- and dose-dependent manner that involved protein kinase C. The phorbol ester also increased PLD activity in the cells. Tetradecanoylphorbol Acetate 136-167 matrix metallopeptidase 9 Homo sapiens 45-71 9873009-2 1999 In this study, we show that the secretion of matrix metalloproteinase-9 (MMP-9) from HT 1080 human fibrosarcoma cells was stimulated by phorbol 12-myristate 13-acetate in a time- and dose-dependent manner that involved protein kinase C. The phorbol ester also increased PLD activity in the cells. Tetradecanoylphorbol Acetate 136-167 matrix metallopeptidase 9 Homo sapiens 73-78 9831704-8 1998 Treatment of VSMCs with the PPARgamma ligands troglitazone and the naturally occurring 15-deoxy-Delta12, 14-prostaglandin J2 (15d-PGJ2) decreased phorbol 12-myristate 13-acetate-induced MMP-9 mRNA and protein levels, as well as MMP-9 gelatinolytic activity in the supernatants in a concentration-dependent manner. Tetradecanoylphorbol Acetate 146-177 matrix metallopeptidase 9 Homo sapiens 186-191 9831704-8 1998 Treatment of VSMCs with the PPARgamma ligands troglitazone and the naturally occurring 15-deoxy-Delta12, 14-prostaglandin J2 (15d-PGJ2) decreased phorbol 12-myristate 13-acetate-induced MMP-9 mRNA and protein levels, as well as MMP-9 gelatinolytic activity in the supernatants in a concentration-dependent manner. Tetradecanoylphorbol Acetate 146-177 matrix metallopeptidase 9 Homo sapiens 228-233 9972133-4 1998 Doxycycline (50 microM) completely inhibited the phorbol-12-myristate-13-acetate (PMA)-mediated induction of MMP-8 and MMP-9, as measured by Western blotting and gelatin zymography, respectively. Tetradecanoylphorbol Acetate 49-80 matrix metallopeptidase 9 Homo sapiens 119-124 9972133-4 1998 Doxycycline (50 microM) completely inhibited the phorbol-12-myristate-13-acetate (PMA)-mediated induction of MMP-8 and MMP-9, as measured by Western blotting and gelatin zymography, respectively. Tetradecanoylphorbol Acetate 82-85 matrix metallopeptidase 9 Homo sapiens 119-124 9665201-5 1998 Whereas 12-O-tetradecanoylphorbol-13 acetate (TPA) increased both MMP-9 and TIMP-1 mRNA levels, tumor necrosis factor-alpha (TNF-alpha) stimulated only MMP-9 gene expression in a dose- and time-dependent manner. Tetradecanoylphorbol Acetate 8-44 matrix metallopeptidase 9 Homo sapiens 66-71 9665201-5 1998 Whereas 12-O-tetradecanoylphorbol-13 acetate (TPA) increased both MMP-9 and TIMP-1 mRNA levels, tumor necrosis factor-alpha (TNF-alpha) stimulated only MMP-9 gene expression in a dose- and time-dependent manner. Tetradecanoylphorbol Acetate 46-49 matrix metallopeptidase 9 Homo sapiens 66-71 9665201-6 1998 Neutralizing monoclonal antibodies (MoABs) to TNF-alpha (anti-TNF-alpha) decreased the constitutive and TPA-dependent expression of MMP-9 but did not influence TIMP-1 expression, either in unstimulated or in TPA-treated NB4 cells. Tetradecanoylphorbol Acetate 104-107 matrix metallopeptidase 9 Homo sapiens 132-137 9593690-4 1998 Cytochalasin-D treatment of SNB19 cells resulted in the loss of phorbol 12-myristate 13-acetate-induced matrix metalloproteinase-9 (also known as gelatinase-B) expression and coincided with inhibition of actin polymerization, resulting in cell rounding. Tetradecanoylphorbol Acetate 64-95 matrix metallopeptidase 9 Homo sapiens 104-130 9622599-6 1998 The effect of TGFbeta2 on Gel B secretion was reversed by phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 58-83 matrix metallopeptidase 9 Homo sapiens 26-31 9622599-6 1998 The effect of TGFbeta2 on Gel B secretion was reversed by phorbol myristate acetate (PMA). Tetradecanoylphorbol Acetate 85-88 matrix metallopeptidase 9 Homo sapiens 26-31 9565574-4 1998 Phorbol 12-myristate 13-acetate (PMA) markedly induced MMP-9 gene expression in HL-60 cells; the induction closely paralleled the timing and extent of PMA-induced cell adhesion and spreading, a hallmark of macrophage differentiation. Tetradecanoylphorbol Acetate 0-31 matrix metallopeptidase 9 Homo sapiens 55-60 9565574-4 1998 Phorbol 12-myristate 13-acetate (PMA) markedly induced MMP-9 gene expression in HL-60 cells; the induction closely paralleled the timing and extent of PMA-induced cell adhesion and spreading, a hallmark of macrophage differentiation. Tetradecanoylphorbol Acetate 33-36 matrix metallopeptidase 9 Homo sapiens 55-60 9568638-6 1998 Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific. Tetradecanoylphorbol Acetate 15-51 matrix metallopeptidase 9 Homo sapiens 117-122 9568638-6 1998 Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific. Tetradecanoylphorbol Acetate 15-51 matrix metallopeptidase 9 Homo sapiens 207-212 9568638-6 1998 Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific. Tetradecanoylphorbol Acetate 53-56 matrix metallopeptidase 9 Homo sapiens 117-122 9568638-6 1998 Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA; 100 nM) induced the mRNAs for TIMP-1 as well as for MMP-1, MMP-9, the uPA receptor, and the uPA inhibitor PAI-1, amongst which only the responses of MMP-9 and PAI-1 were cell-specific. Tetradecanoylphorbol Acetate 53-56 matrix metallopeptidase 9 Homo sapiens 207-212 9568638-8 1998 The secretion of immunoreactive PAI-1 was considerably elevated (> 20-fold) in TPA-treated MCF7/LCC1 cells, whereas the TPA-dependent level of 92-kDa MMP-9 was only approximately 2-fold higher in MCF7/LCC1 cells than in MCF-7 cells. Tetradecanoylphorbol Acetate 123-126 matrix metallopeptidase 9 Homo sapiens 153-158 9520415-5 1998 Three motifs, homologous to the binding sites of NF-kappaB, SP-1, and AP-1 proteins, contribute to induction of the MMP9 promoter by 12-O-tetradecanoyl-phorbol-13-acetate and tumor necrosis factor alpha. Tetradecanoylphorbol Acetate 133-170 matrix metallopeptidase 9 Homo sapiens 116-120 9515796-4 1998 We found that inhibition of p38 by SB 203580 resulted in the almost complete reduction of phorbol myristate acetate-induced MMP-9 secretion but not of urokinase-type plasminogen activator secretion. Tetradecanoylphorbol Acetate 90-115 matrix metallopeptidase 9 Homo sapiens 124-129 9545106-12 1998 In nearly all cell types, treatment with PMA, IL-1, and TNF-alpha caused an increase of the MMP-9 mRNA levels. Tetradecanoylphorbol Acetate 41-44 matrix metallopeptidase 9 Homo sapiens 92-97 21528341-5 1997 More specifically, we observed: (a) increased secretion and/or activation of gelatinases A (MMP-2) and B (MMP-9) after exposure of 8 cell lines to 10(-6) M TPA; (b) increased activation of interstitial collagenase (MMP-1) caseinolysis after stimulation of 3 cancer cell lines with 10(-7) M TPA; and (c) increased activation of MMP-2 after exposure of 2 cell lines to 0.5 mM H3O2. Tetradecanoylphorbol Acetate 156-159 matrix metallopeptidase 9 Homo sapiens 103-111 9374109-7 1997 The phorbol ester phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, significantly increased MMP-9 in AM from healthy control subjects but not in those from untreated asthmatics. Tetradecanoylphorbol Acetate 18-49 matrix metallopeptidase 9 Homo sapiens 117-122 9374109-7 1997 The phorbol ester phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator, significantly increased MMP-9 in AM from healthy control subjects but not in those from untreated asthmatics. Tetradecanoylphorbol Acetate 51-54 matrix metallopeptidase 9 Homo sapiens 117-122 9242444-4 1997 Here, we report the cell surface association of MMP-9 in human breast epithelial MCF10A cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 107-143 matrix metallopeptidase 9 Homo sapiens 48-53 9242444-4 1997 Here, we report the cell surface association of MMP-9 in human breast epithelial MCF10A cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 145-148 matrix metallopeptidase 9 Homo sapiens 48-53 9242444-5 1997 Surface biotinylation and immunoprecipitation with anti-MMP-9 antibodies revealed the presence of two MMP-9 forms (M(r) 92,000 and 85,000) on the surface of TPA-treated MCF10A cells, whereas in the media, only the M(r) 92,000 form was detected, mostly in complex with TIMP-1, a specific MMP-9 inhibitor. Tetradecanoylphorbol Acetate 157-160 matrix metallopeptidase 9 Homo sapiens 56-61 9242444-5 1997 Surface biotinylation and immunoprecipitation with anti-MMP-9 antibodies revealed the presence of two MMP-9 forms (M(r) 92,000 and 85,000) on the surface of TPA-treated MCF10A cells, whereas in the media, only the M(r) 92,000 form was detected, mostly in complex with TIMP-1, a specific MMP-9 inhibitor. Tetradecanoylphorbol Acetate 157-160 matrix metallopeptidase 9 Homo sapiens 102-107 9242444-5 1997 Surface biotinylation and immunoprecipitation with anti-MMP-9 antibodies revealed the presence of two MMP-9 forms (M(r) 92,000 and 85,000) on the surface of TPA-treated MCF10A cells, whereas in the media, only the M(r) 92,000 form was detected, mostly in complex with TIMP-1, a specific MMP-9 inhibitor. Tetradecanoylphorbol Acetate 157-160 matrix metallopeptidase 9 Homo sapiens 102-107 9242444-6 1997 The MMP-9 forms were also found in purified plasma membranes of TPA-treated cells. Tetradecanoylphorbol Acetate 64-67 matrix metallopeptidase 9 Homo sapiens 4-9 9242444-10 1997 These studies demonstrate a specific cell surface association of MMP-9 in response to TPA that may help to localize TIMP-1-free enzyme on the surface of breast epithelial cells. Tetradecanoylphorbol Acetate 86-89 matrix metallopeptidase 9 Homo sapiens 65-70 8613475-4 1996 TPA treatment of HT1080 cells induced the expression of interstitial collagenase (MMP-1) and increased the expression of gelatinase B (MMP-9), tissue inhibitor of metalloproteinases-1 (TIMP-1), and MT-MMP, a membrane-bound activator of progelatinase A (proMMP-2), while MMP-2 and TIMP-2 expression were decreased. Tetradecanoylphorbol Acetate 0-3 matrix metallopeptidase 9 Homo sapiens 135-140 8825424-3 1996 Matrix metalloproteinase-9 activity was induced by phorbol 12-myristate 13-acetate (apical), interleukin-1 alpha (basal), and by conditioned medium from DX3 human melanoma cells (basal). Tetradecanoylphorbol Acetate 51-82 matrix metallopeptidase 9 Homo sapiens 0-26 8045973-8 1994 MMP-9, but not MMP-2, secretion was stimulated by phorbol myristate acetate. Tetradecanoylphorbol Acetate 50-75 matrix metallopeptidase 9 Homo sapiens 0-5 8204888-7 1994 Agents that inhibit TNF-alpha expression in HL-60 cells, such as pentoxifylline and dexamethasone, completely abrogated both the constitutive and TPA-evoked MMP-9 release. Tetradecanoylphorbol Acetate 146-149 matrix metallopeptidase 9 Homo sapiens 157-162 8178929-3 1994 The addition of transforming growth factor-beta (TGF-beta) or phorbolester-TPA to sparse cultures induced low levels of MMP-9 secretion, whereas in confluent cultures only TGF-beta produced this effect. Tetradecanoylphorbol Acetate 75-78 matrix metallopeptidase 9 Homo sapiens 120-125 8178929-5 1994 Treatment of sparse, actively growing cultures but not confluent stationary cultures with both TGF-beta and TPA produced synergistic induction of MMP-9 but did not affect MMP-2. Tetradecanoylphorbol Acetate 108-111 matrix metallopeptidase 9 Homo sapiens 146-151 8280080-12 1993 In human vein endothelial cells it enhanced the PMA-mediated induction of MMP-9, whereas it suppressed this induction in human microvascular endothelial cells and in synovial fibroblasts. Tetradecanoylphorbol Acetate 48-51 matrix metallopeptidase 9 Homo sapiens 74-79 8226872-3 1993 Binding sites for NF-kB, Sp-1, and AP-1 are reportedly required for induction of MMP-9 gene expression by tumor necrosis factor-alpha or 12-O-tetradecanoylphorbol-13-acetate. Tetradecanoylphorbol Acetate 137-173 matrix metallopeptidase 9 Homo sapiens 81-86 8314909-2 1993 12-o-tetradecanoyl 13-phorbol acetate (TPA) differentiated them to macrophage-like cells with induction of MMP-9, and tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) stimulated the production of MMP-9 by TPA-treated cells. Tetradecanoylphorbol Acetate 39-42 matrix metallopeptidase 9 Homo sapiens 107-112 8314909-2 1993 12-o-tetradecanoyl 13-phorbol acetate (TPA) differentiated them to macrophage-like cells with induction of MMP-9, and tumor necrosis factor alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) stimulated the production of MMP-9 by TPA-treated cells. Tetradecanoylphorbol Acetate 39-42 matrix metallopeptidase 9 Homo sapiens 224-229 8314909-3 1993 TNF alpha also induced the production of MMP-9 by TPA-untreated U937 cells without morphological differentiation. Tetradecanoylphorbol Acetate 50-53 matrix metallopeptidase 9 Homo sapiens 41-46 8314909-6 1993 MMP-9 was purified to homogeneity as an inactive zymogen with M(r) 92,000 (proMMP-9) from TPA-differentiated U937 cells treated with TNF alpha. Tetradecanoylphorbol Acetate 90-93 matrix metallopeptidase 9 Homo sapiens 0-5 8356391-4 1993 Subcultured synovial fibroblasts, devoid of macrophages, did not produce MMP-9 as judged by zymography and immunolocalisation; but when stimulated with phorbol myristate acetate and interleukin-1 alpha both MMP-9 and MMP-3 were co-expressed. Tetradecanoylphorbol Acetate 152-177 matrix metallopeptidase 9 Homo sapiens 207-212 1379048-1 1992 The precursor of matrix metalloproteinase 9 (proMMP-9), also known as "92 kDa progelatinase/type IV procollagenase", was purified from the conditioned medium of U937 monocytic leukaemia and HT1080 fibrosarcoma cell lines stimulated with phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 237-268 matrix metallopeptidase 9 Homo sapiens 17-43 1284126-4 1992 In contrast, MMP-3, MMP-9 and TIMP-1 activities were markedly stimulated by TPA in most of the tumor cell lines and human umbilical vein endothelial cells (HUVEC), whereas the fibroblast lines were minimally stimulated or unresponsive to TPA. Tetradecanoylphorbol Acetate 76-79 matrix metallopeptidase 9 Homo sapiens 20-25 1284126-10 1992 Exceptions were the fibroblast cell lines which showed either a much more marked mRNA response of MMP-9 to TPA than observed at protein level, or a high constitutive MMP-9 mRNA when MMP-9 activity was not detectable by zymography. Tetradecanoylphorbol Acetate 107-110 matrix metallopeptidase 9 Homo sapiens 98-103 1284126-11 1992 TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC). Tetradecanoylphorbol Acetate 0-3 matrix metallopeptidase 9 Homo sapiens 28-33 1284126-14 1992 This activity was maximal at 6 h. An association was observed between AP-1 binding activity and increased expression of MMP-1, MMP-3 and MMP-9, which possess TPA-responsive elements (TRE). Tetradecanoylphorbol Acetate 158-161 matrix metallopeptidase 9 Homo sapiens 137-142 11060311-6 2001 Activation of ERKs and JNKs by phorbol 12-myristate 13-acetate and tumor necrosis factor alpha, respectively, leading to increased MMP-9 amounts was not antagonized by KiSS-1 expression, suggesting that MAPK pathways modulating MMP-9 synthesis are not the target of KiSS-1. Tetradecanoylphorbol Acetate 31-62 matrix metallopeptidase 9 Homo sapiens 131-136 11060311-6 2001 Activation of ERKs and JNKs by phorbol 12-myristate 13-acetate and tumor necrosis factor alpha, respectively, leading to increased MMP-9 amounts was not antagonized by KiSS-1 expression, suggesting that MAPK pathways modulating MMP-9 synthesis are not the target of KiSS-1. Tetradecanoylphorbol Acetate 31-62 matrix metallopeptidase 9 Homo sapiens 228-233 34903321-6 2022 Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) changed the expression levels of EMT markers, increasing alpha-SMA, vimentin, and MMP-9 expression and decreasing E-cadherin expression, with changes in cell morphology. Tetradecanoylphorbol Acetate 15-51 matrix metallopeptidase 9 Homo sapiens 140-145 34903321-6 2022 Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) changed the expression levels of EMT markers, increasing alpha-SMA, vimentin, and MMP-9 expression and decreasing E-cadherin expression, with changes in cell morphology. Tetradecanoylphorbol Acetate 53-56 matrix metallopeptidase 9 Homo sapiens 140-145 34903321-9 2022 Inhibition of aurora kinase A blocked TPA-induced vimentin and MMP-9 expression, and decreased E-cadherin expression. Tetradecanoylphorbol Acetate 38-41 matrix metallopeptidase 9 Homo sapiens 63-68 34608498-8 2021 Furthermore, downregulation of matriptase suppressed TPA-induced MMP-9 expression and invasiveness via PAR-2/PLCgamma2/PKC/MAPK activation. Tetradecanoylphorbol Acetate 53-56 matrix metallopeptidase 9 Homo sapiens 65-70 34769032-0 2021 Fluoroquinolones Suppress TGF-beta and PMA-Induced MMP-9 Production in Cancer Cells: Implications in Repurposing Quinolone Antibiotics for Cancer Treatment. Tetradecanoylphorbol Acetate 39-42 matrix metallopeptidase 9 Homo sapiens 51-56 34591419-11 2021 However, treatment with phorbol myristate acetate stimulated the expression of MMP-9, both active and inactive forms in equal proportion. Tetradecanoylphorbol Acetate 24-49 matrix metallopeptidase 9 Homo sapiens 79-84 34374443-7 2021 APLME suppressed the activities of MMP-2 and MMP-9 in PMA (phorbol myristate acetate)-treated HT1080 cells. Tetradecanoylphorbol Acetate 59-84 matrix metallopeptidase 9 Homo sapiens 45-50 34093777-6 2021 The results demonstrated that triptolide decreased the expression of MMP-9 through inhibition of the TPA-induced phosphorylation of extracellular signal-regulated kinase (ERK) and the downregulation of nuclear factor-kappaB (NF-kappaB) and activator protein-1 (AP-1) activity. Tetradecanoylphorbol Acetate 101-104 matrix metallopeptidase 9 Homo sapiens 69-74 34204745-9 2021 The results showed that XN in non-cytotoxic concentrations impaired the PMA-driven migratory and invasive capacity of A549 cells by decreasing the level of expression of MMP-9 and concomitantly increasing the expression of the TIMP-1 protein, i.e., a specific blocker of pro-MMP-9 activation. Tetradecanoylphorbol Acetate 72-75 matrix metallopeptidase 9 Homo sapiens 170-175 35230372-9 2022 MUG1 blunted while Lgals3 amplified neutrophil degranulation in response to phorbol 12-myristate 13-acetate or interleukin-1beta, as measured by MMP-9 secretion. Tetradecanoylphorbol Acetate 76-107 matrix metallopeptidase 9 Homo sapiens 145-150 33760219-0 2021 Bruton"s agammaglobulinemia tyrosine kinase (Btk) regulates TPA-induced breast cancer cell invasion via PLCgamma2/PKCbeta/NF-kappaB/AP-1-dependent matrix metalloproteinase-9 activation. Tetradecanoylphorbol Acetate 60-63 matrix metallopeptidase 9 Homo sapiens 147-173 33760219-5 2021 In this study, the anti-metastatic activity of BTK inhibitors was examined in MCF-7 cells focusing on MMP-9 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated MCF-7 cells. Tetradecanoylphorbol Acetate 122-158 matrix metallopeptidase 9 Homo sapiens 102-107 33760219-5 2021 In this study, the anti-metastatic activity of BTK inhibitors was examined in MCF-7 cells focusing on MMP-9 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated MCF-7 cells. Tetradecanoylphorbol Acetate 160-163 matrix metallopeptidase 9 Homo sapiens 102-107 33760219-10 2021 Collectively, results of the present study indicated that BTK suppressed TPA-induced MMP-9 expression and cell invasion/migration by activating the MAPK or IkappaB kinase/NF-kappaB/activator protein-1 pathway. Tetradecanoylphorbol Acetate 73-76 matrix metallopeptidase 9 Homo sapiens 85-90 33019942-8 2021 It was observed that lapachol above 0.5 microM inhibited the activation of MMP-2 and MMP-9 stimulated by PMA. Tetradecanoylphorbol Acetate 105-108 matrix metallopeptidase 9 Homo sapiens 85-90 31893611-0 2020 Methyl linderone suppresses TPA-stimulated IL-8 and MMP-9 expression via the ERK/STAT3 pathway in MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 28-31 matrix metallopeptidase 9 Homo sapiens 52-57 31893611-6 2020 Moreover, it inhibited two metastasis-related factors, matrix metalloproteinase-9 (MMP-9) and interleukin-8 (IL-8), at the mRNA and protein expression levels, in TPA-treated MCF-7 cells. Tetradecanoylphorbol Acetate 162-165 matrix metallopeptidase 9 Homo sapiens 55-81 31893611-6 2020 Moreover, it inhibited two metastasis-related factors, matrix metalloproteinase-9 (MMP-9) and interleukin-8 (IL-8), at the mRNA and protein expression levels, in TPA-treated MCF-7 cells. Tetradecanoylphorbol Acetate 162-165 matrix metallopeptidase 9 Homo sapiens 83-88 32191627-0 2020 3,5-Dicaffeoyl-epi-quinic acid inhibits the PMA-stimulated activation and expression of MMP-9 but not MMP-2 via downregulation of MAPK pathway. Tetradecanoylphorbol Acetate 44-47 matrix metallopeptidase 9 Homo sapiens 88-93 31939617-4 2020 The results showed that morin hydrate suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell migration and invasion via the inhibition of matrix metalloproteinase (MMP)-9 activity. Tetradecanoylphorbol Acetate 49-85 matrix metallopeptidase 9 Homo sapiens 150-182 31939617-4 2020 The results showed that morin hydrate suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cell migration and invasion via the inhibition of matrix metalloproteinase (MMP)-9 activity. Tetradecanoylphorbol Acetate 87-90 matrix metallopeptidase 9 Homo sapiens 150-182 31432146-4 2019 We used phorbol 12-myristate 13-acetate (PMA), which is known to induce MMP-9 expression and secretion, to stimulate HT1080 cells. Tetradecanoylphorbol Acetate 8-39 matrix metallopeptidase 9 Homo sapiens 72-77 31432146-4 2019 We used phorbol 12-myristate 13-acetate (PMA), which is known to induce MMP-9 expression and secretion, to stimulate HT1080 cells. Tetradecanoylphorbol Acetate 41-44 matrix metallopeptidase 9 Homo sapiens 72-77 31632572-7 2019 In an in vitro assay, after treatment with phorbol myristate acetate (PMA), the THP-1 cells differentiated into M2 macrophages and induced COX2/MMP9-dependent invasiveness in GC cells. Tetradecanoylphorbol Acetate 43-68 matrix metallopeptidase 9 Homo sapiens 144-148 31632572-7 2019 In an in vitro assay, after treatment with phorbol myristate acetate (PMA), the THP-1 cells differentiated into M2 macrophages and induced COX2/MMP9-dependent invasiveness in GC cells. Tetradecanoylphorbol Acetate 70-73 matrix metallopeptidase 9 Homo sapiens 144-148 30668328-6 2019 PG significantly suppressed the phorbol 12-myristate 13-acetate (PMA)-induced increase of matrix metalloproteinase (MMP)-9 expression as well as gelatinolytic MMP-9 activity, which are essential for cancer metastasis. Tetradecanoylphorbol Acetate 32-63 matrix metallopeptidase 9 Homo sapiens 90-122 30668328-6 2019 PG significantly suppressed the phorbol 12-myristate 13-acetate (PMA)-induced increase of matrix metalloproteinase (MMP)-9 expression as well as gelatinolytic MMP-9 activity, which are essential for cancer metastasis. Tetradecanoylphorbol Acetate 65-68 matrix metallopeptidase 9 Homo sapiens 90-122 30590137-8 2019 KA repressed the PMA-induced phosphorylation of Akt, c-Jun N-terminal kinase (JNK) 1/2, and p38 MAPK, which are signaling molecules upstream of MMP-9 expression. Tetradecanoylphorbol Acetate 17-20 matrix metallopeptidase 9 Homo sapiens 144-149 30645596-11 2019 PMA could activate PKCalpha and promote the angiogenesis capacity of human EPCs via NADPH oxidase-mediated, redox-related, MMP-2 and MMP-9 pathways. Tetradecanoylphorbol Acetate 0-3 matrix metallopeptidase 9 Homo sapiens 133-138 30618749-5 2018 ISLA significantly decreased phorbol 12-myristate 13-acetate (PMA)-induced increases in matrix metalloproteinase (MMP) activities and suppressed PMA-induced activation of mitogen-activated protein kinase as well as NF-kappaB, which are involved in cancer metastasis. Tetradecanoylphorbol Acetate 29-60 matrix metallopeptidase 9 Homo sapiens 114-117 30618749-5 2018 ISLA significantly decreased phorbol 12-myristate 13-acetate (PMA)-induced increases in matrix metalloproteinase (MMP) activities and suppressed PMA-induced activation of mitogen-activated protein kinase as well as NF-kappaB, which are involved in cancer metastasis. Tetradecanoylphorbol Acetate 62-65 matrix metallopeptidase 9 Homo sapiens 114-117 30466990-0 2018 Orientin inhibits invasion by suppressing MMP-9 and IL-8 expression via the PKCalpha/ ERK/AP-1/STAT3-mediated signaling pathways in TPA-treated MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 132-135 matrix metallopeptidase 9 Homo sapiens 42-47 30466990-9 2018 CONCLUSION: Orientin inhibits migratory and invasive responses by suppressing MMP-9 and IL-8 expression through mitigation of TPA-induced PKCalpha and ERK activation, as well as the nuclear translocation of AP-1 and STAT3. Tetradecanoylphorbol Acetate 126-129 matrix metallopeptidase 9 Homo sapiens 78-83 30519264-3 2018 In the present study, SE1 potently inhibited gelatin digestion by MMP-9 induced by phorbol 12-myristate 13-acetate (PMA) and migration of human fibrosarcoma HT1080 cells in dose-dependent manner. Tetradecanoylphorbol Acetate 83-114 matrix metallopeptidase 9 Homo sapiens 66-71 30519264-3 2018 In the present study, SE1 potently inhibited gelatin digestion by MMP-9 induced by phorbol 12-myristate 13-acetate (PMA) and migration of human fibrosarcoma HT1080 cells in dose-dependent manner. Tetradecanoylphorbol Acetate 116-119 matrix metallopeptidase 9 Homo sapiens 66-71 30133131-8 2018 These results indicate that mLU8C-PU inhibits migratory and invasive responses in MCF-7 breast cancer cells by suppressing MMP-9 and IL-8 expression through mitigating TPA-induced PKCalpha, JNK activation, and the nuclear translocation of AP-1 and NF-kappaB. Tetradecanoylphorbol Acetate 168-171 matrix metallopeptidase 9 Homo sapiens 123-128 30015874-4 2018 P2X7R may serve a crucial role in the development of atherosclerosis; therefore, the present study aimed to determine whether P2X7R regulated the expression of EMMPRIN and MMP-9 in phorbol 12-myristate 13-acetate (PMA)-induced macrophages. Tetradecanoylphorbol Acetate 181-212 matrix metallopeptidase 9 Homo sapiens 172-177 29630947-3 2018 At non-lethal concentrations, the compounds suppressed in vitro migration of MDA-MB-231 breast carcinoma cells, which was correlated with a dose-dependent downregulation of phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) expression and secretion. Tetradecanoylphorbol Acetate 173-204 matrix metallopeptidase 9 Homo sapiens 247-252 29630947-3 2018 At non-lethal concentrations, the compounds suppressed in vitro migration of MDA-MB-231 breast carcinoma cells, which was correlated with a dose-dependent downregulation of phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) expression and secretion. Tetradecanoylphorbol Acetate 206-209 matrix metallopeptidase 9 Homo sapiens 247-252 29563383-1 2018 To investigate whether focal adhesion kinase (FAK) can participate in the secretion of matrix metalloproteinase 9 (MMP9) after CD147 stimulation in THP-1 induced macrophages; thus, to explore the potential treatment perspectives for acute coronary syndrome (ACS).Phorbol-12-myristate-13-acetate (PMA) was used to induce THP-1 cells to differentiate into macrophages. Tetradecanoylphorbol Acetate 263-294 matrix metallopeptidase 9 Homo sapiens 115-119 29563383-1 2018 To investigate whether focal adhesion kinase (FAK) can participate in the secretion of matrix metalloproteinase 9 (MMP9) after CD147 stimulation in THP-1 induced macrophages; thus, to explore the potential treatment perspectives for acute coronary syndrome (ACS).Phorbol-12-myristate-13-acetate (PMA) was used to induce THP-1 cells to differentiate into macrophages. Tetradecanoylphorbol Acetate 296-299 matrix metallopeptidase 9 Homo sapiens 115-119 29710490-5 2018 In addition, matrix metalloproteinase-9 (MMP-9) activity and mRNA expressions were reversed by proton beam irradiation in TPA-treated HepG2 cells only. Tetradecanoylphorbol Acetate 122-125 matrix metallopeptidase 9 Homo sapiens 13-39 29710490-5 2018 In addition, matrix metalloproteinase-9 (MMP-9) activity and mRNA expressions were reversed by proton beam irradiation in TPA-treated HepG2 cells only. Tetradecanoylphorbol Acetate 122-125 matrix metallopeptidase 9 Homo sapiens 41-46 29710490-8 2018 Therefore, the result demonstrates that the anti-metastatic effects of a proton beam in TPA-treated HepG2 cells are associated with the inhibition of MMP-9 activity and the down-regulations of MMP-9, uPA, uPAR, Snail-1 and VEGF gene expression via the p38 MAPK/c-Fos signaling pathway. Tetradecanoylphorbol Acetate 88-91 matrix metallopeptidase 9 Homo sapiens 150-155 29710490-8 2018 Therefore, the result demonstrates that the anti-metastatic effects of a proton beam in TPA-treated HepG2 cells are associated with the inhibition of MMP-9 activity and the down-regulations of MMP-9, uPA, uPAR, Snail-1 and VEGF gene expression via the p38 MAPK/c-Fos signaling pathway. Tetradecanoylphorbol Acetate 88-91 matrix metallopeptidase 9 Homo sapiens 193-198 29628981-9 2018 12-O-tetradecanoylphorbol-13-acetate (TPA) induced MMP-9 expression and invasion in MCF-7 cell. Tetradecanoylphorbol Acetate 0-36 matrix metallopeptidase 9 Homo sapiens 51-56 29628981-9 2018 12-O-tetradecanoylphorbol-13-acetate (TPA) induced MMP-9 expression and invasion in MCF-7 cell. Tetradecanoylphorbol Acetate 38-41 matrix metallopeptidase 9 Homo sapiens 51-56 29628981-12 2018 The selective PPARgamma antagonist GW9662 reversed MMP-9 inhibition by troglitazone in TPA-treated MCF-7 cells. Tetradecanoylphorbol Acetate 87-90 matrix metallopeptidase 9 Homo sapiens 51-56 29259250-3 2017 Herein, we investigated how Snail upregulated transcription of ZEB1 and MMP9 induced by the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA) in hepatoma cell HepG2. Tetradecanoylphorbol Acetate 107-144 matrix metallopeptidase 9 Homo sapiens 72-76 29259250-3 2017 Herein, we investigated how Snail upregulated transcription of ZEB1 and MMP9 induced by the tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA) in hepatoma cell HepG2. Tetradecanoylphorbol Acetate 146-149 matrix metallopeptidase 9 Homo sapiens 72-76 29259250-4 2017 According to deletion mapping and site directed mutagenesis analysis, the TPA-responsive elements on both MMP9 and ZEB1 promoters locate on a putative EGR1 and SP1 overlapping region coupled with an upstream proposed Snail binding motif TCACA. Tetradecanoylphorbol Acetate 74-77 matrix metallopeptidase 9 Homo sapiens 106-110 29259250-5 2017 Consistently, chromatin immunoprecipitation (ChIP) assay showed TPA triggered binding of Snail, EGR1 and SP1 on MMP9 and ZEB1 promoters. Tetradecanoylphorbol Acetate 64-67 matrix metallopeptidase 9 Homo sapiens 112-116 29259250-7 2017 Also, electrophoresis mobility shift assay revealed TPA enhanced binding of Snail with a MMP9 promoter fragment. Tetradecanoylphorbol Acetate 52-55 matrix metallopeptidase 9 Homo sapiens 89-93 29130110-0 2017 Epimedium koreanum Nakai inhibits PMA-induced cancer cell migration and invasion by modulating NF-kappaB/MMP-9 signaling in monomorphic malignant human glioma cells. Tetradecanoylphorbol Acetate 34-37 matrix metallopeptidase 9 Homo sapiens 105-110 29130110-5 2017 Additionally, pre- or post-treatment with PMA followed by EYK decreased MMP-9 activity in A172 cells. Tetradecanoylphorbol Acetate 42-45 matrix metallopeptidase 9 Homo sapiens 72-77 29130110-8 2017 Taken together, our results suggest that EYK suppresses PMA-induced cancer cell migration in monomorphic malignant human glioma cells by downregulating the NF-kappaB pathway and decreasing MMP-9 activity. Tetradecanoylphorbol Acetate 56-59 matrix metallopeptidase 9 Homo sapiens 189-194 28731287-4 2017 Our results demonstrated that tricetin attenuates 12-O-tetradecanoylphorbol-13-acetate-induced SCC-9, HSC-3, and OECM-1 cell invasiveness and migration by reducing matrix metalloproteinase (MMP)-9 enzyme activity. Tetradecanoylphorbol Acetate 50-86 matrix metallopeptidase 9 Homo sapiens 164-196 28970848-0 2017 Crotonis Fructus Extract Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Expression of Matrix Metalloproteinase-9 via the Activator Protein-1 Pathway in MCF-7 Cells. Tetradecanoylphorbol Acetate 34-70 matrix metallopeptidase 9 Homo sapiens 93-119 28970848-10 2017 CONCLUSION: The results indicated that the inhibitory effects of CFE against TPA-induced MMP-9 expression and MCF-7 cell invasion were dependent on the protein kinase C delta/p38/c-Jun N-terminal kinase/AP-1 pathway. Tetradecanoylphorbol Acetate 77-80 matrix metallopeptidase 9 Homo sapiens 89-94 28927117-0 2017 Salvia miltiorrhiza extract inhibits TPA-induced MMP-9 expression and invasion through the MAPK/AP-1 signaling pathway in human breast cancer MCF-7 cells. Tetradecanoylphorbol Acetate 37-40 matrix metallopeptidase 9 Homo sapiens 49-54 28927117-6 2017 The inhibitory effects of SME on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression were assessed using western blotting, reverse transcription-quantitative polymerase chain reaction and zymography assays. Tetradecanoylphorbol Acetate 33-69 matrix metallopeptidase 9 Homo sapiens 84-89 28927117-6 2017 The inhibitory effects of SME on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression were assessed using western blotting, reverse transcription-quantitative polymerase chain reaction and zymography assays. Tetradecanoylphorbol Acetate 71-74 matrix metallopeptidase 9 Homo sapiens 84-89 28927117-9 2017 The present study demonstrated the inhibitory effects of the SME ethanol solution on MMP-9 expression and cell invasion in TPA-treated MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 123-126 matrix metallopeptidase 9 Homo sapiens 85-90 28927117-10 2017 SME suppressed TPA-induced MMP-9 expression and MCF-7 cell invasion by blocking the transcriptional activation of AP-1. Tetradecanoylphorbol Acetate 15-18 matrix metallopeptidase 9 Homo sapiens 27-32 28969043-3 2017 Isothiocyanates, particularly PEITC, suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 activity and invasion in various cancer cell lines. Tetradecanoylphorbol Acetate 48-84 matrix metallopeptidase 9 Homo sapiens 99-104 28969043-3 2017 Isothiocyanates, particularly PEITC, suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 activity and invasion in various cancer cell lines. Tetradecanoylphorbol Acetate 86-89 matrix metallopeptidase 9 Homo sapiens 99-104 28380444-4 2017 Exposure of human nasopharyngeal carcinoma (NPC) cells to phorbol-12-myristate-13-acetate (PMA) increased the levels of Casp12 and MMP-9 resulting in NPC cell invasion. Tetradecanoylphorbol Acetate 58-89 matrix metallopeptidase 9 Homo sapiens 131-136 28380444-4 2017 Exposure of human nasopharyngeal carcinoma (NPC) cells to phorbol-12-myristate-13-acetate (PMA) increased the levels of Casp12 and MMP-9 resulting in NPC cell invasion. Tetradecanoylphorbol Acetate 91-94 matrix metallopeptidase 9 Homo sapiens 131-136 28098879-9 2017 PMA potently stimulated MMP-9 and had a moderate effect on MMP-2. Tetradecanoylphorbol Acetate 0-3 matrix metallopeptidase 9 Homo sapiens 24-29 27876502-3 2017 MATERIALS AND METHODS: MeOH extracts (MOD) and BuOH extracts (BOD) were prepared and examined for their ability to inhibit phorbol myristate acetate (PMA)-induced matrix metalloproteinase (MMP)-9 and intercellular adhesion molecule (ICAM)-1 expressions in MCF-7 human breast cancer cells. Tetradecanoylphorbol Acetate 123-148 matrix metallopeptidase 9 Homo sapiens 163-195 27876502-3 2017 MATERIALS AND METHODS: MeOH extracts (MOD) and BuOH extracts (BOD) were prepared and examined for their ability to inhibit phorbol myristate acetate (PMA)-induced matrix metalloproteinase (MMP)-9 and intercellular adhesion molecule (ICAM)-1 expressions in MCF-7 human breast cancer cells. Tetradecanoylphorbol Acetate 150-153 matrix metallopeptidase 9 Homo sapiens 163-195 28123548-0 2017 DHA blocks TPA-induced cell invasion by inhibiting MMP-9 expression via suppression of the PPAR-gamma/NF-kappaB pathway in MCF-7 cells. Tetradecanoylphorbol Acetate 11-14 matrix metallopeptidase 9 Homo sapiens 51-56 28123548-4 2017 The present study investigated the inhibitory effect of DHA on MMP-9 expression and cell invasion induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the MCF-7 breast cancer cell line. Tetradecanoylphorbol Acetate 109-145 matrix metallopeptidase 9 Homo sapiens 63-68 28123548-4 2017 The present study investigated the inhibitory effect of DHA on MMP-9 expression and cell invasion induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the MCF-7 breast cancer cell line. Tetradecanoylphorbol Acetate 147-150 matrix metallopeptidase 9 Homo sapiens 63-68 27600920-0 2016 Melatonin suppresses TPA-induced metastasis by downregulating matrix metalloproteinase-9 expression through JNK/SP-1 signaling in nasopharyngeal carcinoma. Tetradecanoylphorbol Acetate 21-24 matrix metallopeptidase 9 Homo sapiens 62-88 27600920-4 2016 Here, we show that melatonin treatment inhibits TPA-induced cell motility by regulating the matrix metalloproteinase-9 (MMP-9) expression in NPC. Tetradecanoylphorbol Acetate 48-51 matrix metallopeptidase 9 Homo sapiens 92-118 27600920-4 2016 Here, we show that melatonin treatment inhibits TPA-induced cell motility by regulating the matrix metalloproteinase-9 (MMP-9) expression in NPC. Tetradecanoylphorbol Acetate 48-51 matrix metallopeptidase 9 Homo sapiens 120-125 27600920-8 2016 Thus, we conclude that melatonin suppresses the motility of NPC by regulating TPA-induced MMP-9 gene expression via inhibiting SP-1-DNA binding ability. Tetradecanoylphorbol Acetate 78-81 matrix metallopeptidase 9 Homo sapiens 90-95 27737648-3 2016 METHODS AND RESULTS: Exposure of NPC cells to phorbol-12-myristate-13-acetate (PMA) or macrophage conditioned media (CM) upregulated MMP-9 and N-cadherin cleavage, which resulted in NPC cell invasion. Tetradecanoylphorbol Acetate 46-77 matrix metallopeptidase 9 Homo sapiens 133-138 27737648-3 2016 METHODS AND RESULTS: Exposure of NPC cells to phorbol-12-myristate-13-acetate (PMA) or macrophage conditioned media (CM) upregulated MMP-9 and N-cadherin cleavage, which resulted in NPC cell invasion. Tetradecanoylphorbol Acetate 79-82 matrix metallopeptidase 9 Homo sapiens 133-138 27035791-6 2016 Rev-AuNPs suppressed TPA-induced enzymatic activity and the expression of matrix metalloproteinase (MMP)-9 and cyclooxygenase-2 (COX-2). Tetradecanoylphorbol Acetate 21-24 matrix metallopeptidase 9 Homo sapiens 74-106 27035791-12 2016 Our findings revealed that the anti-invasive effects of Rev-AuNPs in response to TPA-stimulation were mediated by the suppression of MMP-9, COX-2, NF-kappaB, AP-1, PI3K/Akt and ERK and/or the activation of HO-1 signaling cascades. Tetradecanoylphorbol Acetate 81-84 matrix metallopeptidase 9 Homo sapiens 133-138 26614570-8 2016 Atorvastatin attenuated PMA-induced MMP-9 gelatinolytic activity by mechanisms not involving NO, although it increased nitrite concentrations, whereas sildenafil had no effects. Tetradecanoylphorbol Acetate 24-27 matrix metallopeptidase 9 Homo sapiens 36-41 27476935-3 2016 p-Cymene was found to dose-dependently inhibit the 12-O-tetradecanoylphorbol 13-acetate (TPA)-augmented production and gene expression of MMP-9 in HT-1080 cells. Tetradecanoylphorbol Acetate 51-87 matrix metallopeptidase 9 Homo sapiens 138-143 27476935-3 2016 p-Cymene was found to dose-dependently inhibit the 12-O-tetradecanoylphorbol 13-acetate (TPA)-augmented production and gene expression of MMP-9 in HT-1080 cells. Tetradecanoylphorbol Acetate 89-92 matrix metallopeptidase 9 Homo sapiens 138-143 26717978-5 2016 (PJT) on MMP-9 expression and the invasion of MCF-7 breast cancer cells induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 83-119 matrix metallopeptidase 9 Homo sapiens 9-14 26717978-5 2016 (PJT) on MMP-9 expression and the invasion of MCF-7 breast cancer cells induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 121-124 matrix metallopeptidase 9 Homo sapiens 9-14 26717978-8 2016 The results indicated that the PJT-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involved the suppression of the PKCalpha/NF-kappaB pathway in MCF-7 cells. Tetradecanoylphorbol Acetate 58-61 matrix metallopeptidase 9 Homo sapiens 70-75 26498639-11 2015 The levels of MMP-2, MMP-9, E-cad and integrin beta1 in the TPA-induced A549 cells changed markedly, compared with the untreated cells. Tetradecanoylphorbol Acetate 60-63 matrix metallopeptidase 9 Homo sapiens 21-26 26397194-5 2015 The inhibitory effects of ITCs on PMA-induced MMP-9 expression were found to be associated with the inhibition of MMP-9 transcription levels through suppression of nuclear translocation of NF-kappaB and activator protein-1 (AP-1). Tetradecanoylphorbol Acetate 34-37 matrix metallopeptidase 9 Homo sapiens 46-51 26397194-5 2015 The inhibitory effects of ITCs on PMA-induced MMP-9 expression were found to be associated with the inhibition of MMP-9 transcription levels through suppression of nuclear translocation of NF-kappaB and activator protein-1 (AP-1). Tetradecanoylphorbol Acetate 34-37 matrix metallopeptidase 9 Homo sapiens 114-119 26608825-5 2015 In HT1080 cells, TSG101 depletion increased both baseline and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion through enhancing MMP-9 mRNA expression, but did not affect the expression or activation of MMP-2. Tetradecanoylphorbol Acetate 62-93 matrix metallopeptidase 9 Homo sapiens 108-113 26608825-5 2015 In HT1080 cells, TSG101 depletion increased both baseline and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion through enhancing MMP-9 mRNA expression, but did not affect the expression or activation of MMP-2. Tetradecanoylphorbol Acetate 95-98 matrix metallopeptidase 9 Homo sapiens 108-113 26414495-7 2015 Production of reactive oxygen species (ROS) induced by PMA (126.7 +- 2.1%) was markedly attenuated by curcumin, DMC, and BDMC to 99.5 +- 7.8%, 87.8 +- 8.2%, and 89.8 +- 7.6%, respectively, resulting in the down-regulation of CD11b and MMP-9 expression. Tetradecanoylphorbol Acetate 55-58 matrix metallopeptidase 9 Homo sapiens 235-240 26101063-0 2015 Fisetin regulates TPA-induced breast cell invasion by suppressing matrix metalloproteinase-9 activation via the PKC/ROS/MAPK pathways. Tetradecanoylphorbol Acetate 18-21 matrix metallopeptidase 9 Homo sapiens 66-92 26101063-4 2015 Matrix metalloproteinase (MMP)-9 is a major component facilitating the invasion of many cancer tumor cell types, and thus the inhibitory effect of fisetin on MMP-9 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated human breast cancer cells was investigated in this study. Tetradecanoylphorbol Acetate 178-214 matrix metallopeptidase 9 Homo sapiens 158-163 26101063-4 2015 Matrix metalloproteinase (MMP)-9 is a major component facilitating the invasion of many cancer tumor cell types, and thus the inhibitory effect of fisetin on MMP-9 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated human breast cancer cells was investigated in this study. Tetradecanoylphorbol Acetate 216-219 matrix metallopeptidase 9 Homo sapiens 0-32 25401496-0 2015 Resveratrol suppresses TPA-induced matrix metalloproteinase-9 expression through the inhibition of MAPK pathways in oral cancer cells. Tetradecanoylphorbol Acetate 23-26 matrix metallopeptidase 9 Homo sapiens 35-61 25401496-8 2015 Zymography and Western blot analyses suggested that resveratrol inhibited TPA-induced MMP-9 gelatinolytic activity and protein expression. Tetradecanoylphorbol Acetate 74-77 matrix metallopeptidase 9 Homo sapiens 86-91 26044736-6 2015 Moreover, the inhibition of Aurora kinases by their siRNAs and inhibitors suppressed TPA-induced cell invasion and expression of MMP-9 by inhibiting the activation of NF-kappaB/AP-1, major transcription factors for MMP-9 expression in MCF-7 cells. Tetradecanoylphorbol Acetate 85-88 matrix metallopeptidase 9 Homo sapiens 129-134 26044736-6 2015 Moreover, the inhibition of Aurora kinases by their siRNAs and inhibitors suppressed TPA-induced cell invasion and expression of MMP-9 by inhibiting the activation of NF-kappaB/AP-1, major transcription factors for MMP-9 expression in MCF-7 cells. Tetradecanoylphorbol Acetate 85-88 matrix metallopeptidase 9 Homo sapiens 215-220 25997494-9 2015 On gelatinase zymography, SK-Hep-1 showed bands corresponding to MMP-2 and MMP-9 with enhancement of MMP-9 with PMA (100 ng/ml) treatment. Tetradecanoylphorbol Acetate 112-115 matrix metallopeptidase 9 Homo sapiens 101-106 26171065-0 2015 Hispolon inhibits TPA-induced invasion by reducing MMP-9 expression through the NF-kappaB signaling pathway in MDA-MB-231 human breast cancer cells. Tetradecanoylphorbol Acetate 18-21 matrix metallopeptidase 9 Homo sapiens 51-56 26171065-5 2015 Hispolon also prevented the TPA-induced secretion of matrix metalloproteinase-9 (MMP-9) and reduced its expression at the transcriptional and translational levels. Tetradecanoylphorbol Acetate 28-31 matrix metallopeptidase 9 Homo sapiens 53-79 26171065-5 2015 Hispolon also prevented the TPA-induced secretion of matrix metalloproteinase-9 (MMP-9) and reduced its expression at the transcriptional and translational levels. Tetradecanoylphorbol Acetate 28-31 matrix metallopeptidase 9 Homo sapiens 81-86 26171065-9 2015 In conclusion, the results of the present study indicated that hispolon inhibited TPA-induced migration and invasion of MDA-MB-231 cells by reducing the secretion and expression of MMP-9 through the NF-kappaB signaling pathway. Tetradecanoylphorbol Acetate 82-85 matrix metallopeptidase 9 Homo sapiens 181-186 26137162-0 2015 Failure of matrix metalloproteinase-9 dimer induction by phorbol 12-myristate 13-acetate in normal human cell lines. Tetradecanoylphorbol Acetate 57-88 matrix metallopeptidase 9 Homo sapiens 11-37 26137162-8 2015 The aim of the present study was to analyze the expression patterns of MMP-2, MMP-9 and MMP-9 dimer in normal human cells from a number of tissues treated with PMA. Tetradecanoylphorbol Acetate 160-163 matrix metallopeptidase 9 Homo sapiens 78-83 26137162-8 2015 The aim of the present study was to analyze the expression patterns of MMP-2, MMP-9 and MMP-9 dimer in normal human cells from a number of tissues treated with PMA. Tetradecanoylphorbol Acetate 160-163 matrix metallopeptidase 9 Homo sapiens 88-93 25912851-9 2015 alpha-Asarone increased the expression levels of MMP-2 and MMP-9 stimulated by phenazine methosulfate (PMS) and phorbol 12-myristate 13-acetate (PMA) in HT1080. Tetradecanoylphorbol Acetate 112-143 matrix metallopeptidase 9 Homo sapiens 59-64 25912851-9 2015 alpha-Asarone increased the expression levels of MMP-2 and MMP-9 stimulated by phenazine methosulfate (PMS) and phorbol 12-myristate 13-acetate (PMA) in HT1080. Tetradecanoylphorbol Acetate 145-148 matrix metallopeptidase 9 Homo sapiens 59-64 25941985-4 2015 Treatment with CPT also downregulated phorbol-12-myristate-13-acetate (PMA)- and tumor necrosis factor-alpha (TNF-alpha)-induced MMP-9 and VEGF expression by inhibiting nuclear factor-kappaB (NF-kappaB) activity. Tetradecanoylphorbol Acetate 38-69 matrix metallopeptidase 9 Homo sapiens 129-134 25941985-4 2015 Treatment with CPT also downregulated phorbol-12-myristate-13-acetate (PMA)- and tumor necrosis factor-alpha (TNF-alpha)-induced MMP-9 and VEGF expression by inhibiting nuclear factor-kappaB (NF-kappaB) activity. Tetradecanoylphorbol Acetate 71-74 matrix metallopeptidase 9 Homo sapiens 129-134 25941985-6 2015 We further confirmed that CPT inhibits PMA-induced MMP-9 and VEGF expression by upregulating nuclear factor-erythroid related factor-2 (Nrf2)-mediated heme oxygenase-1 (HO-1) induction. Tetradecanoylphorbol Acetate 39-42 matrix metallopeptidase 9 Homo sapiens 51-56 25695860-5 2015 Cells were also treated with PMA to induce MMP-9 activity. Tetradecanoylphorbol Acetate 29-32 matrix metallopeptidase 9 Homo sapiens 43-48 25670016-3 2015 We further show that glaucine significantly blocks phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression and activity in a dose-dependent manner. Tetradecanoylphorbol Acetate 51-82 matrix metallopeptidase 9 Homo sapiens 97-102 25670016-3 2015 We further show that glaucine significantly blocks phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression and activity in a dose-dependent manner. Tetradecanoylphorbol Acetate 84-87 matrix metallopeptidase 9 Homo sapiens 97-102 25875631-9 2015 Chrysin inhibited phorbol-12-myristate 13-acetate (PMA)-induced MMP-9 expression in a dose-dependent manner. Tetradecanoylphorbol Acetate 18-49 matrix metallopeptidase 9 Homo sapiens 64-69 25875631-9 2015 Chrysin inhibited phorbol-12-myristate 13-acetate (PMA)-induced MMP-9 expression in a dose-dependent manner. Tetradecanoylphorbol Acetate 51-54 matrix metallopeptidase 9 Homo sapiens 64-69 25840633-6 2015 The effects of these compounds on phorbol 12-myristate 13-acetate (PMA)- induced MMP-9 gene and protein expression in airway epithelial cells (NCI-H292) were also investigated. Tetradecanoylphorbol Acetate 34-65 matrix metallopeptidase 9 Homo sapiens 81-86 25840633-6 2015 The effects of these compounds on phorbol 12-myristate 13-acetate (PMA)- induced MMP-9 gene and protein expression in airway epithelial cells (NCI-H292) were also investigated. Tetradecanoylphorbol Acetate 67-70 matrix metallopeptidase 9 Homo sapiens 81-86 25840633-13 2015 Furthermore, crude Phlai extracts (100 mg/ml) and compound D, at concentrations of 50 and 100 mg/ml, attenuated the PMA-induced MMP-9 gene and expression in NCI-H292 cells. Tetradecanoylphorbol Acetate 116-119 matrix metallopeptidase 9 Homo sapiens 128-133 25698902-4 2015 Furthermore, the results of gelatin zymography and reverse transcriptase polymerase chain reaction (RT-PCR) assays showed that galangin reduced the TPA-induced enzyme activity of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in HepG2 cells; moreover, the messenger RNA level was downregulated. Tetradecanoylphorbol Acetate 148-151 matrix metallopeptidase 9 Homo sapiens 218-244 25698902-4 2015 Furthermore, the results of gelatin zymography and reverse transcriptase polymerase chain reaction (RT-PCR) assays showed that galangin reduced the TPA-induced enzyme activity of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in HepG2 cells; moreover, the messenger RNA level was downregulated. Tetradecanoylphorbol Acetate 148-151 matrix metallopeptidase 9 Homo sapiens 246-251 25453494-6 2015 Moreover, kaempferol repressed phorbol-12-myristate-13-acetate (PMA)-induced MMP-9 expression and activity through suppressing the translocation of protein kinase Cdelta (PKCdelta) and MAPK signaling pathway. Tetradecanoylphorbol Acetate 31-62 matrix metallopeptidase 9 Homo sapiens 77-82 25453494-6 2015 Moreover, kaempferol repressed phorbol-12-myristate-13-acetate (PMA)-induced MMP-9 expression and activity through suppressing the translocation of protein kinase Cdelta (PKCdelta) and MAPK signaling pathway. Tetradecanoylphorbol Acetate 64-67 matrix metallopeptidase 9 Homo sapiens 77-82 25518925-2 2015 In this study, we analyzed the effect of flavonols on MMP-9 expression in phorbol-12-myristate-13-acetate (PMA)-induced human fibrosarcoma HT-1080 cells. Tetradecanoylphorbol Acetate 74-105 matrix metallopeptidase 9 Homo sapiens 54-59 25518925-2 2015 In this study, we analyzed the effect of flavonols on MMP-9 expression in phorbol-12-myristate-13-acetate (PMA)-induced human fibrosarcoma HT-1080 cells. Tetradecanoylphorbol Acetate 107-110 matrix metallopeptidase 9 Homo sapiens 54-59 25520561-8 2014 Furthermore, recombinant cavin-3 significantly prevented PMA-mediated dephosphorylation of AKT, a crucial regulator in MMP-9 transcription. Tetradecanoylphorbol Acetate 57-60 matrix metallopeptidase 9 Homo sapiens 119-124 25479224-9 2014 In the nasal epithelial cells of patients with allergic rhinitis, EGCG significantly decreased phorbol 12-myristate 13-acetate (PMA)-induced MUC5B and MMP-9 expression. Tetradecanoylphorbol Acetate 95-126 matrix metallopeptidase 9 Homo sapiens 151-156 25479224-9 2014 In the nasal epithelial cells of patients with allergic rhinitis, EGCG significantly decreased phorbol 12-myristate 13-acetate (PMA)-induced MUC5B and MMP-9 expression. Tetradecanoylphorbol Acetate 128-131 matrix metallopeptidase 9 Homo sapiens 151-156 25282183-1 2014 BACKGROUND: Matrix metalloproteinase-9 (MMP-9) plays a key role for the blood-brain barrier disruption and intravenous tissue plasminogen activator (iv-tPA) therapy increases MMP-9. Tetradecanoylphorbol Acetate 152-155 matrix metallopeptidase 9 Homo sapiens 12-38 25282183-1 2014 BACKGROUND: Matrix metalloproteinase-9 (MMP-9) plays a key role for the blood-brain barrier disruption and intravenous tissue plasminogen activator (iv-tPA) therapy increases MMP-9. Tetradecanoylphorbol Acetate 152-155 matrix metallopeptidase 9 Homo sapiens 40-45 25282183-1 2014 BACKGROUND: Matrix metalloproteinase-9 (MMP-9) plays a key role for the blood-brain barrier disruption and intravenous tissue plasminogen activator (iv-tPA) therapy increases MMP-9. Tetradecanoylphorbol Acetate 152-155 matrix metallopeptidase 9 Homo sapiens 175-180 25282183-3 2014 We aimed to investigate whether edaravone would suppress the MMP-9 increase after iv-tPA using low-dose alteplase (0.6 mg/kg). Tetradecanoylphorbol Acetate 85-88 matrix metallopeptidase 9 Homo sapiens 61-66 25174454-10 2014 The siRNA studies also showed that PMA-induced MMP-9 expression is NF-kappaB-dependent. Tetradecanoylphorbol Acetate 35-38 matrix metallopeptidase 9 Homo sapiens 47-52 25260594-8 2014 Further investigation disclosed that the AP-1 activator TPA-induced MMP9 activity and the TPA-promoted migration and invasion of hepatoma cells were significantly attenuated by miR-101 but were enhanced by miR-101 inhibitor. Tetradecanoylphorbol Acetate 56-59 matrix metallopeptidase 9 Homo sapiens 68-72 25244493-8 2014 Inhibition of ERK activation blocks phorbol myristate acetate-induced MMP-9 activity and VEGF-A secretion in vitro. Tetradecanoylphorbol Acetate 36-61 matrix metallopeptidase 9 Homo sapiens 70-75 25241044-8 2014 Furthermore, curcumin reversed PMA stimulated PKC activation and suppressed the chronic activation of AMPK, which in turn reduced the expression of MMP-9, MMP-13 and EMMPRIN. Tetradecanoylphorbol Acetate 31-34 matrix metallopeptidase 9 Homo sapiens 148-153 25123184-6 2014 EGCG treatment significantly decreased mRNA and protein expression levels of MMP-9 in the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) and tumor necrosis factor alpha (TNF-alpha) in human retinal pigment epithelial cells (HRPECs). Tetradecanoylphorbol Acetate 102-138 matrix metallopeptidase 9 Homo sapiens 77-82 25123184-6 2014 EGCG treatment significantly decreased mRNA and protein expression levels of MMP-9 in the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) and tumor necrosis factor alpha (TNF-alpha) in human retinal pigment epithelial cells (HRPECs). Tetradecanoylphorbol Acetate 140-143 matrix metallopeptidase 9 Homo sapiens 77-82 24867464-10 2014 On gelatinase zymography, all three cell lines showed bands corresponding to MMP-2 and LN-18 and T-98G showed PMA (100 ng/ml)-induced MMP-9. Tetradecanoylphorbol Acetate 110-113 matrix metallopeptidase 9 Homo sapiens 134-139 25000305-0 2014 Delphinidin suppresses PMA-induced MMP-9 expression by blocking the NF-kappaB activation through MAPK signaling pathways in MCF-7 human breast carcinoma cells. Tetradecanoylphorbol Acetate 23-26 matrix metallopeptidase 9 Homo sapiens 35-40 25000305-2 2014 The synthesis and secretion of MMP-9 can be stimulated by a variety of stimuli, including cytokines and phorbol 12-myristate 13-acetate (PMA), during various pathological processes, such as tumor invasion, atherosclerosis, inflammation, and rheumatoid arthritis, whereas MMP-2 is usually expressed constitutively. Tetradecanoylphorbol Acetate 104-135 matrix metallopeptidase 9 Homo sapiens 31-36 25000305-2 2014 The synthesis and secretion of MMP-9 can be stimulated by a variety of stimuli, including cytokines and phorbol 12-myristate 13-acetate (PMA), during various pathological processes, such as tumor invasion, atherosclerosis, inflammation, and rheumatoid arthritis, whereas MMP-2 is usually expressed constitutively. Tetradecanoylphorbol Acetate 137-140 matrix metallopeptidase 9 Homo sapiens 31-36 25000305-4 2014 In this study, we investigated the antiproliferative and antiinvasive effects of delphinidin on PMA-induced MMP-9 expression in MCF-7 human breast carcinoma cells using zymography, western blotting, reverse transcription-polymerase chain reaction, and Matrigel invasion assay. Tetradecanoylphorbol Acetate 96-99 matrix metallopeptidase 9 Homo sapiens 108-113 25000305-5 2014 Delphinidin significantly suppressed PMA-induced MMP-9 protein expression in MCF-7 human breast carcinoma cells, and it also inhibited the MMP-9 gene transcriptional activity by blocking the activation of NFkappaB (NF-kappaB) through MAPK signaling pathways. Tetradecanoylphorbol Acetate 37-40 matrix metallopeptidase 9 Homo sapiens 49-54 25000305-7 2014 These results suggest that delphinidin is a potential antimetastatic agent that suppresses PMA-induced cancer cell invasion through the specific inhibition of NF-kappaB-dependent MMP-9 gene expression. Tetradecanoylphorbol Acetate 91-94 matrix metallopeptidase 9 Homo sapiens 179-184 24859472-4 2014 The results revealed that 12-O-tetradecanoylphorbol-13-acetate-induced increases in COX-2 and MMP-9 expression levels were reversed by proton beam irradiation in a dose-dependent manner. Tetradecanoylphorbol Acetate 26-62 matrix metallopeptidase 9 Homo sapiens 94-99 24486723-8 2014 In addition, MED significantly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced CCA cells invasion in a dose-dependent manner by reducing the expression of matrix metalloelastase 9 (MMP-9). Tetradecanoylphorbol Acetate 79-82 matrix metallopeptidase 9 Homo sapiens 194-199 24789371-4 2014 We found that shikonin inhibited phorbol 12-myristate 13-acetate (PMA)-induced cell migration and invasion in MCF-7 breast cancer cells, which was correlated with modulation of matrix metalloproteinase-9 (MMP-9) through suppression of both expression and proteolytic and promoter activity. Tetradecanoylphorbol Acetate 33-64 matrix metallopeptidase 9 Homo sapiens 177-203 24789371-4 2014 We found that shikonin inhibited phorbol 12-myristate 13-acetate (PMA)-induced cell migration and invasion in MCF-7 breast cancer cells, which was correlated with modulation of matrix metalloproteinase-9 (MMP-9) through suppression of both expression and proteolytic and promoter activity. Tetradecanoylphorbol Acetate 33-64 matrix metallopeptidase 9 Homo sapiens 205-210 24789371-4 2014 We found that shikonin inhibited phorbol 12-myristate 13-acetate (PMA)-induced cell migration and invasion in MCF-7 breast cancer cells, which was correlated with modulation of matrix metalloproteinase-9 (MMP-9) through suppression of both expression and proteolytic and promoter activity. Tetradecanoylphorbol Acetate 66-69 matrix metallopeptidase 9 Homo sapiens 177-203 24789371-4 2014 We found that shikonin inhibited phorbol 12-myristate 13-acetate (PMA)-induced cell migration and invasion in MCF-7 breast cancer cells, which was correlated with modulation of matrix metalloproteinase-9 (MMP-9) through suppression of both expression and proteolytic and promoter activity. Tetradecanoylphorbol Acetate 66-69 matrix metallopeptidase 9 Homo sapiens 205-210 24885456-0 2014 Saussurea lappa extract suppresses TPA-induced cell invasion via inhibition of NF-kappaB-dependent MMP-9 expression in MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 35-38 matrix metallopeptidase 9 Homo sapiens 99-104 24885456-13 2014 Therefore, ELS-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of NF-kB pathway in MCF-7 cells. Tetradecanoylphorbol Acetate 38-41 matrix metallopeptidase 9 Homo sapiens 50-55 24885456-14 2014 CONCLUSIONS: These results indicate that ELS-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of NF-kB pathway in MCF-7 cells. Tetradecanoylphorbol Acetate 68-71 matrix metallopeptidase 9 Homo sapiens 80-85 24286317-5 2014 Furthermore, Bis knockdown notably decreased TPA-induced matrix metalloproteinase-9 (MMP-9) activity and mRNA expression, as measured by zymography and quantitative real time PCR, respectively. Tetradecanoylphorbol Acetate 45-48 matrix metallopeptidase 9 Homo sapiens 57-83 24286317-5 2014 Furthermore, Bis knockdown notably decreased TPA-induced matrix metalloproteinase-9 (MMP-9) activity and mRNA expression, as measured by zymography and quantitative real time PCR, respectively. Tetradecanoylphorbol Acetate 45-48 matrix metallopeptidase 9 Homo sapiens 85-90 24604087-0 2014 Decursin prevents TPA-induced invasion through suppression of PKCalpha/p38/NF-kappaB-dependent MMP-9 expression in MCF-7 human breast carcinoma cells. Tetradecanoylphorbol Acetate 18-21 matrix metallopeptidase 9 Homo sapiens 95-100 24604087-5 2014 Therefore, in this study, we investigated the inhibitory effect of decursin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion, as well as the molecular mechanisms involved in MCF-7 cells. Tetradecanoylphorbol Acetate 79-115 matrix metallopeptidase 9 Homo sapiens 130-135 24604087-5 2014 Therefore, in this study, we investigated the inhibitory effect of decursin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion, as well as the molecular mechanisms involved in MCF-7 cells. Tetradecanoylphorbol Acetate 117-120 matrix metallopeptidase 9 Homo sapiens 130-135 24604087-6 2014 Our results showed that decursin inhibits TPA-induced MMP-9 expression and cell invasion through the suppression of NF-kappaB. Tetradecanoylphorbol Acetate 42-45 matrix metallopeptidase 9 Homo sapiens 54-59 24604087-8 2014 These results indicate that decursin-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the PKCalpha, MAPK and NF-kappaB pathways in MCF-7 cells. Tetradecanoylphorbol Acetate 60-63 matrix metallopeptidase 9 Homo sapiens 72-77 24378964-7 2014 Parallel sets of cultures were treated with PMA (100 ng/ml) for induction of MMP-9. Tetradecanoylphorbol Acetate 44-47 matrix metallopeptidase 9 Homo sapiens 77-82 24173318-7 2014 Luciferase assays showed that HF decreases TPA-induced MMP-9 promoter binding activities of NF-kappaB and AP-1. Tetradecanoylphorbol Acetate 43-46 matrix metallopeptidase 9 Homo sapiens 55-60 24190483-6 2014 Osteosarcoma and rhabdomyosarcoma showed bands corresponding to MMP-2 and -9 with dose-dependent enhancement of MMP-9 with phorbol 12-myristate 13-acetate (PMA) treatment. Tetradecanoylphorbol Acetate 123-154 matrix metallopeptidase 9 Homo sapiens 112-117 24190483-6 2014 Osteosarcoma and rhabdomyosarcoma showed bands corresponding to MMP-2 and -9 with dose-dependent enhancement of MMP-9 with phorbol 12-myristate 13-acetate (PMA) treatment. Tetradecanoylphorbol Acetate 156-159 matrix metallopeptidase 9 Homo sapiens 112-117 24174064-5 2014 Matrix metalloproteinase-9 (MMP-9) activity in the resting and PMA-stimulated state in HT1080 cells was dose-dependently decreased by KIOM-C treatment via suppression of NF-kappaB activation. Tetradecanoylphorbol Acetate 63-66 matrix metallopeptidase 9 Homo sapiens 0-26 24174064-5 2014 Matrix metalloproteinase-9 (MMP-9) activity in the resting and PMA-stimulated state in HT1080 cells was dose-dependently decreased by KIOM-C treatment via suppression of NF-kappaB activation. Tetradecanoylphorbol Acetate 63-66 matrix metallopeptidase 9 Homo sapiens 28-33 24220687-0 2014 Sanguinarine inhibits invasiveness and the MMP-9 and COX-2 expression in TPA-induced breast cancer cells by inducing HO-1 expression. Tetradecanoylphorbol Acetate 73-76 matrix metallopeptidase 9 Homo sapiens 43-48 24220687-5 2014 The results showed that sanguinarine inhibited TPA-induced MMP-9 and COX-2 mRNA and protein expression in a dose-dependent manner at non-cytotoxic concentrations. Tetradecanoylphorbol Acetate 47-50 matrix metallopeptidase 9 Homo sapiens 59-64 24353864-10 2013 In addition, SB203580 and MMP-9 I (MMP-9 inhibitor) significantly decreased PMA-induced MUC5B expression. Tetradecanoylphorbol Acetate 76-79 matrix metallopeptidase 9 Homo sapiens 26-31 24353864-10 2013 In addition, SB203580 and MMP-9 I (MMP-9 inhibitor) significantly decreased PMA-induced MUC5B expression. Tetradecanoylphorbol Acetate 76-79 matrix metallopeptidase 9 Homo sapiens 35-40 24085323-5 2013 Fibrosarcoma, chondrosarcoma, liposarcoma and synovial sarcoma showed bands corresponding to MMP-2 and MMP-9 with dose-dependent enhancement of MMP-9 with phorbol 12-myristate 13-acetate (PMA) treatment. Tetradecanoylphorbol Acetate 155-186 matrix metallopeptidase 9 Homo sapiens 103-108 24085323-5 2013 Fibrosarcoma, chondrosarcoma, liposarcoma and synovial sarcoma showed bands corresponding to MMP-2 and MMP-9 with dose-dependent enhancement of MMP-9 with phorbol 12-myristate 13-acetate (PMA) treatment. Tetradecanoylphorbol Acetate 155-186 matrix metallopeptidase 9 Homo sapiens 144-149 24085323-5 2013 Fibrosarcoma, chondrosarcoma, liposarcoma and synovial sarcoma showed bands corresponding to MMP-2 and MMP-9 with dose-dependent enhancement of MMP-9 with phorbol 12-myristate 13-acetate (PMA) treatment. Tetradecanoylphorbol Acetate 188-191 matrix metallopeptidase 9 Homo sapiens 103-108 24085323-5 2013 Fibrosarcoma, chondrosarcoma, liposarcoma and synovial sarcoma showed bands corresponding to MMP-2 and MMP-9 with dose-dependent enhancement of MMP-9 with phorbol 12-myristate 13-acetate (PMA) treatment. Tetradecanoylphorbol Acetate 188-191 matrix metallopeptidase 9 Homo sapiens 144-149 23933110-0 2013 Luteolin 8-C-beta-fucopyranoside inhibits invasion and suppresses TPA-induced MMP-9 and IL-8 via ERK/AP-1 and ERK/NF-kappaB signaling in MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 66-69 matrix metallopeptidase 9 Homo sapiens 78-83 23933110-4 2013 LU8C-FP suppressed TPA-induced MMP-9 and IL-8 secretion and mRNA expression via inhibition of the MAPK signaling pathway and down-regulation of nuclear AP-1 and NF-kappaB. Tetradecanoylphorbol Acetate 19-22 matrix metallopeptidase 9 Homo sapiens 31-36 24152909-5 2013 The expression of MMP-9 and cell invasion increased after TPA treatment, whereas TPA-induced MMP-9 expression and cell invasion were decreased by BVT948 pretreatment. Tetradecanoylphorbol Acetate 58-61 matrix metallopeptidase 9 Homo sapiens 18-23 24152909-5 2013 The expression of MMP-9 and cell invasion increased after TPA treatment, whereas TPA-induced MMP-9 expression and cell invasion were decreased by BVT948 pretreatment. Tetradecanoylphorbol Acetate 81-84 matrix metallopeptidase 9 Homo sapiens 93-98 24008507-7 2013 Similar to the inhibitory effects shown in MDA-MB-231 cells, we observed that DSW treatment resulted in the inhibition of TPA-induced migration and MMP-9 activity with a concomitant decrease in mRNA levels of MMP-9, TGF-beta, Wnt5a and Wnt3a. Tetradecanoylphorbol Acetate 122-125 matrix metallopeptidase 9 Homo sapiens 148-153 23879967-7 2013 Meanwhile upregulating the [Ca2+]i either by TG or phorbol myristate acetate (PMA) could stimulate the production of MMP-9 in A375 cells with the expression of Basigin. Tetradecanoylphorbol Acetate 51-76 matrix metallopeptidase 9 Homo sapiens 117-122 23879967-7 2013 Meanwhile upregulating the [Ca2+]i either by TG or phorbol myristate acetate (PMA) could stimulate the production of MMP-9 in A375 cells with the expression of Basigin. Tetradecanoylphorbol Acetate 78-81 matrix metallopeptidase 9 Homo sapiens 117-122 23900236-10 2013 U-2OS osteosarcoma cells showed strong bands corresponding to inactive MMP-2 and MMP-9 and faint bands corresponding to active MMP-2 and MMP-9 dimer; PMA treatment enhanced MMP-9 and MMP-9 dimer activity. Tetradecanoylphorbol Acetate 150-153 matrix metallopeptidase 9 Homo sapiens 137-142 23900236-9 2013 On gelatinase zymography, osteosarcoma MNNG-HOS showed a band corresponding to MMP-2 and induction of MMP-9 with PMA (100 ng/ml) treatment. Tetradecanoylphorbol Acetate 113-116 matrix metallopeptidase 9 Homo sapiens 102-107 23900236-10 2013 U-2OS osteosarcoma cells showed strong bands corresponding to inactive MMP-2 and MMP-9 and faint bands corresponding to active MMP-2 and MMP-9 dimer; PMA treatment enhanced MMP-9 and MMP-9 dimer activity. Tetradecanoylphorbol Acetate 150-153 matrix metallopeptidase 9 Homo sapiens 81-86 23900236-10 2013 U-2OS osteosarcoma cells showed strong bands corresponding to inactive MMP-2 and MMP-9 and faint bands corresponding to active MMP-2 and MMP-9 dimer; PMA treatment enhanced MMP-9 and MMP-9 dimer activity. Tetradecanoylphorbol Acetate 150-153 matrix metallopeptidase 9 Homo sapiens 137-142 23900236-10 2013 U-2OS osteosarcoma cells showed strong bands corresponding to inactive MMP-2 and MMP-9 and faint bands corresponding to active MMP-2 and MMP-9 dimer; PMA treatment enhanced MMP-9 and MMP-9 dimer activity. Tetradecanoylphorbol Acetate 150-153 matrix metallopeptidase 9 Homo sapiens 137-142 23900236-11 2013 Rhabdomyosarcoma showed MMP-2 and faint MMP-9 bands; PMA treatment enhanced MMP-9 expression. Tetradecanoylphorbol Acetate 53-56 matrix metallopeptidase 9 Homo sapiens 76-81 24053256-0 2013 Selaginella tamariscina extract suppresses TPA-induced invasion and metastasis through inhibition of MMP-9 in human nasopharyngeal carcinoma HONE-1 cells. Tetradecanoylphorbol Acetate 43-46 matrix metallopeptidase 9 Homo sapiens 101-106 24053256-7 2013 Treatment of STE on TPA-induced HONE-1 cells inhibited MMP-9 expression and ERK1/2 phosphorylation without affecting JNK and p38 phosphorylation. Tetradecanoylphorbol Acetate 20-23 matrix metallopeptidase 9 Homo sapiens 55-60 23758794-4 2013 Compound IVn was also found to inhibit PMA-induced MMP-9 expression in MDA-MB-231 cells at sublethal concentrations. Tetradecanoylphorbol Acetate 39-42 matrix metallopeptidase 9 Homo sapiens 51-56 24089228-13 2013 It was noteworthy that the ERK activator (phorbol 12-myristate 13-acetate [PMA]) treatment increased the MMP-9/VEGF levels after propofol treatment, and led to significant increase of proliferation, invasion and angiogenesis. Tetradecanoylphorbol Acetate 42-73 matrix metallopeptidase 9 Homo sapiens 105-110 24089228-13 2013 It was noteworthy that the ERK activator (phorbol 12-myristate 13-acetate [PMA]) treatment increased the MMP-9/VEGF levels after propofol treatment, and led to significant increase of proliferation, invasion and angiogenesis. Tetradecanoylphorbol Acetate 75-78 matrix metallopeptidase 9 Homo sapiens 105-110 24084455-5 2013 Phorbol 12-myristate 13-acetate (PMA), 100 ng/ml was added to cells to induce MMP-9 secretion. Tetradecanoylphorbol Acetate 0-31 matrix metallopeptidase 9 Homo sapiens 78-83 24084455-5 2013 Phorbol 12-myristate 13-acetate (PMA), 100 ng/ml was added to cells to induce MMP-9 secretion. Tetradecanoylphorbol Acetate 33-36 matrix metallopeptidase 9 Homo sapiens 78-83 24084455-8 2013 Zymography did not demonstrate MMP-2 or MMP-9 secretion in normal cells; however, PMA strongly induced MMP-9, which was inhibited by NM in a dose-dependent manner. Tetradecanoylphorbol Acetate 82-85 matrix metallopeptidase 9 Homo sapiens 103-108 23615401-0 2013 Induction of heme oxygenase-1 and inhibition of TPA-induced matrix metalloproteinase-9 expression by andrographolide in MCF-7 human breast cancer cells. Tetradecanoylphorbol Acetate 48-51 matrix metallopeptidase 9 Homo sapiens 60-86 23615401-4 2013 In this study, we investigated the effect of AP on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and invasion in MCF-7 breast cancer cells and the possible mechanisms involved. Tetradecanoylphorbol Acetate 51-87 matrix metallopeptidase 9 Homo sapiens 102-107 23615401-4 2013 In this study, we investigated the effect of AP on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and invasion in MCF-7 breast cancer cells and the possible mechanisms involved. Tetradecanoylphorbol Acetate 89-92 matrix metallopeptidase 9 Homo sapiens 102-107 23615401-5 2013 The results showed that AP dose-dependently inhibited TPA-induced MMP-9 protein expression, enzyme activity, migration and invasion. Tetradecanoylphorbol Acetate 54-57 matrix metallopeptidase 9 Homo sapiens 66-71 23615401-8 2013 HO-1 end products, such as carbon monoxide, free iron and bilirubin, suppressed the TPA-induced MMP-9 mRNA and protein expression, enzyme activity, migration and invasion in MCF-7 cells. Tetradecanoylphorbol Acetate 84-87 matrix metallopeptidase 9 Homo sapiens 96-101 23615401-10 2013 In conclusion, these results suggest that AP inhibits TPA-induced cell migration and invasion by reducing MMP-9 activation, which is mediated mainly by inhibition of the ERK1/2 and phosphatidylinositol 3-kinase/Akt signaling pathways and subsequent AP-1 and NF-kappaB transactivation. Tetradecanoylphorbol Acetate 54-57 matrix metallopeptidase 9 Homo sapiens 106-111 23615401-11 2013 Additionally, induction of HO-1 expression is at least partially involved in the inhibition of TPA-induced MMP-9 activation and cell migration in MCF-7 cells by AP. Tetradecanoylphorbol Acetate 95-98 matrix metallopeptidase 9 Homo sapiens 107-112 23661254-10 2013 On gelatinase zymography, fibrosarcoma, chondrosarcoma, liposarcoma and synovial sarcoma showed bands corresponding to MMP-2 and MMP-9 with enhancement of MMP-9 with PMA (100 ng/ml) treatment. Tetradecanoylphorbol Acetate 166-169 matrix metallopeptidase 9 Homo sapiens 155-160 23661254-11 2013 Uterine leiomyosarcoma showed strong bands corresponding to inactive and active MMP-9 and a faint band corresponding to MMP-9 dimer induced with PMA treatment, but no MMP-2 band. Tetradecanoylphorbol Acetate 145-148 matrix metallopeptidase 9 Homo sapiens 120-125 23563849-10 2013 On gelatinase zymography, A-549 cells showed one band corresponding to MMP-2 and induction of MMP-9 with PMA (100 ng/ml) treatment. Tetradecanoylphorbol Acetate 105-108 matrix metallopeptidase 9 Homo sapiens 94-99 23563849-11 2013 MSTO-211H showed two bands, an intense band corresponding to MMP-2 and a faint band corresponding to MMP-9; MMP-9 was enhanced significantly with PMA treatment. Tetradecanoylphorbol Acetate 146-149 matrix metallopeptidase 9 Homo sapiens 101-106 23563849-11 2013 MSTO-211H showed two bands, an intense band corresponding to MMP-2 and a faint band corresponding to MMP-9; MMP-9 was enhanced significantly with PMA treatment. Tetradecanoylphorbol Acetate 146-149 matrix metallopeptidase 9 Homo sapiens 108-113 23456480-4 2013 We studied the effects of DetaNONOate (10-400 muM) or SNAP (50-400 muM) on phorbol 12-myristate 13-acetate (PMA; 10 nM)-induced increases in MMP-9 activity (by gel zymography) or concentrations (by ELISA) as well as on a tissue inhibitor of MMPs" (TIMP)-1 concentrations (by ELISA) in the conditioned medium of HUVECs incubated for 24 h with these drugs. Tetradecanoylphorbol Acetate 75-106 matrix metallopeptidase 9 Homo sapiens 141-146 23456480-4 2013 We studied the effects of DetaNONOate (10-400 muM) or SNAP (50-400 muM) on phorbol 12-myristate 13-acetate (PMA; 10 nM)-induced increases in MMP-9 activity (by gel zymography) or concentrations (by ELISA) as well as on a tissue inhibitor of MMPs" (TIMP)-1 concentrations (by ELISA) in the conditioned medium of HUVECs incubated for 24 h with these drugs. Tetradecanoylphorbol Acetate 108-111 matrix metallopeptidase 9 Homo sapiens 141-146 23456480-5 2013 We also examined whether the irreversible inhibitor of soluble guanylyl cyclase ODQ modified the effects of SNAP or whether 8-bromo-cGMP (a cell-permeable analog of cGMP) influenced PMA-induced effects on MMP-9 expression. Tetradecanoylphorbol Acetate 182-185 matrix metallopeptidase 9 Homo sapiens 205-210 23288142-0 2013 Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. Tetradecanoylphorbol Acetate 108-144 matrix metallopeptidase 9 Homo sapiens 14-40 23288142-4 2013 We found that TPA (100 ng/ml) induced MMP-9 enzyme activity both dose- and time-dependently, and 200 muM DHA and LA significantly inhibited MMP-9 mRNA and protein expression, enzyme activity, cell migration, and invasion. Tetradecanoylphorbol Acetate 14-17 matrix metallopeptidase 9 Homo sapiens 38-43 23288142-5 2013 Treatment with PD98059 (10 muM), wortmannin (10 muM), and GF109203X (0.5 muM) decreased TPA-induced MMP-9 protein expression and enzyme activity. Tetradecanoylphorbol Acetate 88-91 matrix metallopeptidase 9 Homo sapiens 100-105 23288142-10 2013 HO-1 siRNA alleviated the inhibition by DHA of TPA-induced MMP-9 protein expression and enzyme activity in MCF-7 cells, and HO-1 knockdown reversed the DHA inhibition of cell migration. Tetradecanoylphorbol Acetate 47-50 matrix metallopeptidase 9 Homo sapiens 59-64 23114726-0 2013 Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 breast adenocarcinoma cells invasion/migration by alpha-tomatine through activating PKCalpha/ERK/NF-kappaB-dependent MMP-2/MMP-9 expressions. Tetradecanoylphorbol Acetate 15-51 matrix metallopeptidase 9 Homo sapiens 189-194 23114726-7 2013 The treatment of specific inhibitor for ERK (U0126) to MCF-7 cells could inhibit TPA-induced MMP-2/MMP-9 and phospho-ERK along with an inhibition on cell invasion and migration. Tetradecanoylphorbol Acetate 81-84 matrix metallopeptidase 9 Homo sapiens 99-104 23671446-8 2013 RESULTS: Midazolam significantly down-regulated PMA-induced MMP-9 protein expression at concentrations of 5, 10 and 20 microM, the values were 1.95 +-0.09 (p < 0.01), 1.71 +-0.12 (p < 0.01) and 1.35 +-0.20 (p < 0.001), respectively. Tetradecanoylphorbol Acetate 48-51 matrix metallopeptidase 9 Homo sapiens 60-65 23615261-0 2013 Sulforaphane controls TPA-induced MMP-9 expression through the NF-kappaB signaling pathway, but not AP-1, in MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 22-25 matrix metallopeptidase 9 Homo sapiens 34-39 23615261-4 2013 In this study, we investigated the effect of sulforaphane on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. Tetradecanoylphorbol Acetate 61-98 matrix metallopeptidase 9 Homo sapiens 113-118 23615261-4 2013 In this study, we investigated the effect of sulforaphane on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. Tetradecanoylphorbol Acetate 100-103 matrix metallopeptidase 9 Homo sapiens 113-118 23615261-5 2013 TPA-induced MMP-9 expression and cell invasion were decreased by sulforaphane treatment. Tetradecanoylphorbol Acetate 0-3 matrix metallopeptidase 9 Homo sapiens 12-17 23615261-9 2013 In this study, we demonstrated that the inhibition of TPA-induced MMP-9 expression and cell invasion by sulforaphane was mediated by the suppression of the NF-kappaB pathway in MCF-7 cells. Tetradecanoylphorbol Acetate 54-57 matrix metallopeptidase 9 Homo sapiens 66-71 23353996-3 2013 Our results revealed that the levels of MMP-9 mRNA and protein expression were significantly increased by TPA but not MMP-2 in TPC-1 and MCF7 cells. Tetradecanoylphorbol Acetate 118-121 matrix metallopeptidase 9 Homo sapiens 52-57 23353996-4 2013 To verify the regulatory mechanism of TPA-induced MMP-9 expression, we treated TPC-1 and MCF7 cells with the MEK1/2 inhibitor, UO126, and TPA-induced MMP-9 expression was significantly decreased. Tetradecanoylphorbol Acetate 38-41 matrix metallopeptidase 9 Homo sapiens 62-67 23353996-4 2013 To verify the regulatory mechanism of TPA-induced MMP-9 expression, we treated TPC-1 and MCF7 cells with the MEK1/2 inhibitor, UO126, and TPA-induced MMP-9 expression was significantly decreased. Tetradecanoylphorbol Acetate 38-41 matrix metallopeptidase 9 Homo sapiens 174-179 23353996-4 2013 To verify the regulatory mechanism of TPA-induced MMP-9 expression, we treated TPC-1 and MCF7 cells with the MEK1/2 inhibitor, UO126, and TPA-induced MMP-9 expression was significantly decreased. Tetradecanoylphorbol Acetate 162-165 matrix metallopeptidase 9 Homo sapiens 62-67 23353996-4 2013 To verify the regulatory mechanism of TPA-induced MMP-9 expression, we treated TPC-1 and MCF7 cells with the MEK1/2 inhibitor, UO126, and TPA-induced MMP-9 expression was significantly decreased. Tetradecanoylphorbol Acetate 162-165 matrix metallopeptidase 9 Homo sapiens 174-179 23353996-5 2013 We also found that TPA-induced cell migration and MMP-9 expression was significantly decreased by silibinin. Tetradecanoylphorbol Acetate 31-34 matrix metallopeptidase 9 Homo sapiens 62-67 23528311-5 2013 The cells were also treated with PMA to induce MMP-9 expression. Tetradecanoylphorbol Acetate 33-36 matrix metallopeptidase 9 Homo sapiens 47-52 23292685-0 2013 Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-kappaB-dependent MMP-9 expression. Tetradecanoylphorbol Acetate 15-18 matrix metallopeptidase 9 Homo sapiens 111-116 23292685-6 2013 In this study, we investigated the inhibitory effect of sulfuretin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. Tetradecanoylphorbol Acetate 82-118 matrix metallopeptidase 9 Homo sapiens 145-150 23292685-6 2013 In this study, we investigated the inhibitory effect of sulfuretin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. Tetradecanoylphorbol Acetate 120-123 matrix metallopeptidase 9 Homo sapiens 145-150 23292685-8 2013 We demonstrated that sulfuretin mediated the inhibition of TPA-induced MMP-9 expression and that cell invasion in MCF-7 cells involved suppression of the NF-kappaB pathway. Tetradecanoylphorbol Acetate 71-74 matrix metallopeptidase 9 Homo sapiens 83-88 23242121-2 2013 In this study, we investigated the inhibitory effects of guggulsterone isomers (cis or trans) on 12-O-tetradecanoylpho-bol-13-acetate (TPA)-induced MMP-9 expression. Tetradecanoylphorbol Acetate 159-162 matrix metallopeptidase 9 Homo sapiens 172-177 23242121-4 2013 Cis-guggulsterone was more potent than trans-guggulsterone in the inhibition of TPA-induced MMP-9 expression and invasion of MCF-7 cells. Tetradecanoylphorbol Acetate 92-95 matrix metallopeptidase 9 Homo sapiens 104-109 23151889-0 2013 Surfactin suppresses TPA-induced breast cancer cell invasion through the inhibition of MMP-9 expression. Tetradecanoylphorbol Acetate 21-24 matrix metallopeptidase 9 Homo sapiens 87-92 23007964-5 2012 Cells were also treated with phorbol 12-myristate 13-acetate (PMA) to induce matrix metalloproteinase (MMP)-9 activity. Tetradecanoylphorbol Acetate 29-60 matrix metallopeptidase 9 Homo sapiens 77-109 23007964-5 2012 Cells were also treated with phorbol 12-myristate 13-acetate (PMA) to induce matrix metalloproteinase (MMP)-9 activity. Tetradecanoylphorbol Acetate 62-65 matrix metallopeptidase 9 Homo sapiens 77-109 22740037-0 2012 Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-kappaB activation in TPA-induced breast cancer cells. Tetradecanoylphorbol Acetate 119-122 matrix metallopeptidase 9 Homo sapiens 57-62 22740037-3 2012 In the present study, we investigated the inhibitory effects of ar-turmerone on expression and enzymatic activity levels of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase (MMP)-9 and cyclooxygenaase-2 (COX-2) in breast cancer cells. Tetradecanoylphorbol Acetate 124-160 matrix metallopeptidase 9 Homo sapiens 175-207 22740037-3 2012 In the present study, we investigated the inhibitory effects of ar-turmerone on expression and enzymatic activity levels of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase (MMP)-9 and cyclooxygenaase-2 (COX-2) in breast cancer cells. Tetradecanoylphorbol Acetate 162-165 matrix metallopeptidase 9 Homo sapiens 175-207 22740037-9 2012 Thus, transfection of breast cancer cells with PI3K/Akt and ERK1/2 siRNAs significantly decreased TPA-induced MMP-9 and COX-2 expression. Tetradecanoylphorbol Acetate 98-101 matrix metallopeptidase 9 Homo sapiens 110-115 22740037-10 2012 These results suggest that ar-turmerone suppressed the TPA-induced up-regulation of MMP-9 and COX-2 expression by blocking NF-kappaB, PI3K/Akt, and ERK1/2 signaling in human breast cancer cells. Tetradecanoylphorbol Acetate 55-58 matrix metallopeptidase 9 Homo sapiens 84-89 22921746-4 2012 In this study, we investigated the inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion and the molecular mechanisms involved in MCF-7 cells. Tetradecanoylphorbol Acetate 68-104 matrix metallopeptidase 9 Homo sapiens 119-124 22921746-4 2012 In this study, we investigated the inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion and the molecular mechanisms involved in MCF-7 cells. Tetradecanoylphorbol Acetate 106-109 matrix metallopeptidase 9 Homo sapiens 119-124 22921746-5 2012 Our results showed that curcumin inhibits TPA-induced MMP-9 expression and cell invasion through suppressing NF-kappaB and AP-1 activation. Tetradecanoylphorbol Acetate 42-45 matrix metallopeptidase 9 Homo sapiens 54-59 22921746-7 2012 These results indicate that curcumin-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the PKCalpha, MAPK and NF-kappaB/AP-1 pathway in MCF-7 cells. Tetradecanoylphorbol Acetate 60-63 matrix metallopeptidase 9 Homo sapiens 72-77 22488409-2 2012 Here, we show that 4-HPR blocks the activity of MMP-9 in two ways: by reducing phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion and by suppressing cell invasion through the downregulation of MMP-9 gene transcription in MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 79-110 matrix metallopeptidase 9 Homo sapiens 48-53 22488409-2 2012 Here, we show that 4-HPR blocks the activity of MMP-9 in two ways: by reducing phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion and by suppressing cell invasion through the downregulation of MMP-9 gene transcription in MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 79-110 matrix metallopeptidase 9 Homo sapiens 125-130 22488409-2 2012 Here, we show that 4-HPR blocks the activity of MMP-9 in two ways: by reducing phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion and by suppressing cell invasion through the downregulation of MMP-9 gene transcription in MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 79-110 matrix metallopeptidase 9 Homo sapiens 125-130 22488409-2 2012 Here, we show that 4-HPR blocks the activity of MMP-9 in two ways: by reducing phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion and by suppressing cell invasion through the downregulation of MMP-9 gene transcription in MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 112-115 matrix metallopeptidase 9 Homo sapiens 48-53 22488409-2 2012 Here, we show that 4-HPR blocks the activity of MMP-9 in two ways: by reducing phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion and by suppressing cell invasion through the downregulation of MMP-9 gene transcription in MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 112-115 matrix metallopeptidase 9 Homo sapiens 125-130 22488409-2 2012 Here, we show that 4-HPR blocks the activity of MMP-9 in two ways: by reducing phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 secretion and by suppressing cell invasion through the downregulation of MMP-9 gene transcription in MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 112-115 matrix metallopeptidase 9 Homo sapiens 125-130 22773582-0 2012 Sorafenib inhibits TPA-induced MMP-9 and VEGF expression via suppression of ERK/NF-kappaB pathway in hepatocellular carcinoma cells. Tetradecanoylphorbol Acetate 19-22 matrix metallopeptidase 9 Homo sapiens 31-36 22773582-4 2012 TPA increased the NF-kappaB activity and the expressions of MMP-9 and VEGF significantly, but its effects were suppressed by sorafenib in a dose-dependent manner. Tetradecanoylphorbol Acetate 0-3 matrix metallopeptidase 9 Homo sapiens 60-65 22773582-6 2012 Furthermore, transfection of Huh7 cell with an inhibitor of kappaB-alpha mutant vector, led to reduced TPA-induced MMP-9 and VEGF mRNA expressions. Tetradecanoylphorbol Acetate 103-106 matrix metallopeptidase 9 Homo sapiens 115-120 22773582-7 2012 Sorafenib inhibits TPA-induced MMP-9 and VEGF expressions via the suppression of ERK/NF-kappaB pathway in HCC cells. Tetradecanoylphorbol Acetate 19-22 matrix metallopeptidase 9 Homo sapiens 31-36 22381172-0 2012 Berberine suppresses the TPA-induced MMP-1 and MMP-9 expressions through the inhibition of PKC-alpha in breast cancer cells. Tetradecanoylphorbol Acetate 25-28 matrix metallopeptidase 9 Homo sapiens 47-52 22381172-9 2012 In contrast, TPA, which is a tumor promoter, significantly increased the levels of the MMP-1 and MMP-9 mRNA and protein expressions in the MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 13-16 matrix metallopeptidase 9 Homo sapiens 97-102 22381172-10 2012 We also observed that the TPA-induced MMP-1 and MMP-9 mRNA and protein expressions were prevented by BBR treatment. Tetradecanoylphorbol Acetate 26-29 matrix metallopeptidase 9 Homo sapiens 48-53 22381172-11 2012 In addition, the TPA-induced MMP-1 and MMP-9 expressions were completely decreased by Go6983 and PKC-alpha siRNA, respectively. Tetradecanoylphorbol Acetate 17-20 matrix metallopeptidase 9 Homo sapiens 39-44 22381172-13 2012 CONCLUSION: The TPA-induced PKC-alpha phosphorylation is suppressed and then the MMP-1 and MMP-9 expressions are also inhibited by berberine. Tetradecanoylphorbol Acetate 16-19 matrix metallopeptidase 9 Homo sapiens 91-96 22465218-4 2012 In the present study, we found that mangiferin, a glucosylxanthone isolated from Anemarrhena asphodeloides, specifically inhibited MMP-9 gene expression in phorbol myristate acetate (PMA)-stimulated human astroglioma U87MG, U373MG, and CRT-MG cells. Tetradecanoylphorbol Acetate 156-181 matrix metallopeptidase 9 Homo sapiens 131-136 22465218-4 2012 In the present study, we found that mangiferin, a glucosylxanthone isolated from Anemarrhena asphodeloides, specifically inhibited MMP-9 gene expression in phorbol myristate acetate (PMA)-stimulated human astroglioma U87MG, U373MG, and CRT-MG cells. Tetradecanoylphorbol Acetate 183-186 matrix metallopeptidase 9 Homo sapiens 131-136 22465218-8 2012 Further mechanistic studies demonstrated that mangiferin inhibits the binding of NF-kappaB and AP-1 to the MMP-9 promoter and suppresses the PMA-induced phosphorylation of Akt and MAP kinases, which are upstream signaling molecules in MMP-9 expression. Tetradecanoylphorbol Acetate 141-144 matrix metallopeptidase 9 Homo sapiens 235-240 22151918-7 2012 RESULTS: Cucurbitacin B has significantly suppressed 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced cell invasion and migration in a concentration-dependent manner, which was accompanied with suppression of TPA-induced MMP-9 expression through inactivation of phosphorylation of extracellular signal-regulated kinase (ERK) 1/2, p38 and Akt. Tetradecanoylphorbol Acetate 93-96 matrix metallopeptidase 9 Homo sapiens 225-230 24213313-11 2012 MMP-2 and MMP-9 activities were further modulated by phorbol 12-myristate 13-acetate (PMA) induction and inhibited by NM. Tetradecanoylphorbol Acetate 53-84 matrix metallopeptidase 9 Homo sapiens 10-15 24213313-11 2012 MMP-2 and MMP-9 activities were further modulated by phorbol 12-myristate 13-acetate (PMA) induction and inhibited by NM. Tetradecanoylphorbol Acetate 86-89 matrix metallopeptidase 9 Homo sapiens 10-15 22382313-2 2012 The present study was performed to determine the anti-invasive effect of Kalopanaxsaponin A (KPS-A) on matrix metalloproteinase-9 (MMP-9)-meidated invasion in phorbol 12-myristate 13-acetate (PMA)-stimulated human oral squamous cell carcinoma (OSCC) cells and a murine xenograft model of human OSCC. Tetradecanoylphorbol Acetate 159-190 matrix metallopeptidase 9 Homo sapiens 103-129 22382313-2 2012 The present study was performed to determine the anti-invasive effect of Kalopanaxsaponin A (KPS-A) on matrix metalloproteinase-9 (MMP-9)-meidated invasion in phorbol 12-myristate 13-acetate (PMA)-stimulated human oral squamous cell carcinoma (OSCC) cells and a murine xenograft model of human OSCC. Tetradecanoylphorbol Acetate 159-190 matrix metallopeptidase 9 Homo sapiens 131-136 22382313-2 2012 The present study was performed to determine the anti-invasive effect of Kalopanaxsaponin A (KPS-A) on matrix metalloproteinase-9 (MMP-9)-meidated invasion in phorbol 12-myristate 13-acetate (PMA)-stimulated human oral squamous cell carcinoma (OSCC) cells and a murine xenograft model of human OSCC. Tetradecanoylphorbol Acetate 192-195 matrix metallopeptidase 9 Homo sapiens 103-129 22382313-2 2012 The present study was performed to determine the anti-invasive effect of Kalopanaxsaponin A (KPS-A) on matrix metalloproteinase-9 (MMP-9)-meidated invasion in phorbol 12-myristate 13-acetate (PMA)-stimulated human oral squamous cell carcinoma (OSCC) cells and a murine xenograft model of human OSCC. Tetradecanoylphorbol Acetate 192-195 matrix metallopeptidase 9 Homo sapiens 131-136 22382313-4 2012 KPS-A treatment reduced the stability of PMA-induced MMP-9 mRNA and inhibited the PMA-induced cytoplasmic translocation of HuR. Tetradecanoylphorbol Acetate 41-44 matrix metallopeptidase 9 Homo sapiens 53-58 22523472-7 2012 HBMEC were treated with a combination of resveratrol and phorbol 12-myristate 13-acetate (PMA), a carcinogen known to increase MMP-9 and COX-2 through NF-kappaB. Tetradecanoylphorbol Acetate 57-88 matrix metallopeptidase 9 Homo sapiens 127-132 22523472-7 2012 HBMEC were treated with a combination of resveratrol and phorbol 12-myristate 13-acetate (PMA), a carcinogen known to increase MMP-9 and COX-2 through NF-kappaB. Tetradecanoylphorbol Acetate 90-93 matrix metallopeptidase 9 Homo sapiens 127-132 22523472-8 2012 We found that resveratrol efficiently reversed the PMA-induced MMP-9 secretion and COX-2 expression. Tetradecanoylphorbol Acetate 51-54 matrix metallopeptidase 9 Homo sapiens 63-68 22293298-0 2012 The cadin-2-en-1beta-ol-1beta-D-glucuronopyranoside suppresses TPA-mediated matrix metalloproteinase-9 expression through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells. Tetradecanoylphorbol Acetate 63-66 matrix metallopeptidase 9 Homo sapiens 76-102 22293298-6 2012 Zymographic analysis showed that CR4-1 suppressed TPA-induced MMP-9 activity in a dose-dependent manner. Tetradecanoylphorbol Acetate 50-53 matrix metallopeptidase 9 Homo sapiens 62-67 21947138-7 2012 In both cell lines, zymography demonstrated a band corresponding to MMP-2 in normal cells and MMP-9 with phorbol 12-myristate 13-acetate treatment. Tetradecanoylphorbol Acetate 117-148 matrix metallopeptidase 9 Homo sapiens 106-111 22879913-3 2012 Although it has been widely noted that interferon-beta (IFNbeta) downregulates both the basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression at the transcriptional level, the molecular mechanism of this repression is poorly understood. Tetradecanoylphorbol Acetate 98-129 matrix metallopeptidase 9 Homo sapiens 144-149 22879913-3 2012 Although it has been widely noted that interferon-beta (IFNbeta) downregulates both the basal and phorbol 12-myristate 13-acetate (PMA)-induced MMP-9 expression at the transcriptional level, the molecular mechanism of this repression is poorly understood. Tetradecanoylphorbol Acetate 131-134 matrix metallopeptidase 9 Homo sapiens 144-149 22232712-0 2011 The Effect of Doxycycline on PMA-Induced MUC5B Expression via MMP-9 and p38 in NCI-H292 Cells. Tetradecanoylphorbol Acetate 29-32 matrix metallopeptidase 9 Homo sapiens 62-67 22232712-5 2011 Therefore, the effects and signal pathways of doxycycline on PMA-induced MUC5B expression dependent MMP-9 in human airway epithelial cells were investigated. Tetradecanoylphorbol Acetate 61-64 matrix metallopeptidase 9 Homo sapiens 100-105 22232712-6 2011 METHODS: In human NCI-H292 airway epithelial cells, MUC5B and MMP-9 mRNA expression, MUC5B protein expression, and MMP-9 protein activity after the treatment with PMA, MMP-9 or doxycycline were determined by reverse transcriptase-polymerase chain reaction, enzyme immunoassay, gelatin zymography, and Western blot analysis. Tetradecanoylphorbol Acetate 163-166 matrix metallopeptidase 9 Homo sapiens 62-67 22232712-9 2011 Doxycycline inhibited PMA-induced MUC5B expression, and PMA-induced MMP-9 mRNA expression and protein activity. Tetradecanoylphorbol Acetate 56-59 matrix metallopeptidase 9 Homo sapiens 68-73 22232712-11 2011 CONCLUSION: The results of this study suggest that doxycycline inhibited PMA-induced MUC5B mRNA expression and protein production through the MMP-9 and p38 pathways in human NCI-H292 airway epithelial cells. Tetradecanoylphorbol Acetate 73-76 matrix metallopeptidase 9 Homo sapiens 142-147 22217709-7 2011 Zymography revealed matrix MMP-2 and phorbol 12-myristate 13-acetate induced MMP-9 expression. Tetradecanoylphorbol Acetate 37-68 matrix metallopeptidase 9 Homo sapiens 77-82 21925496-3 2011 The present study aimed to investigate the modulating effects of cilostazol on monocyte invasion and the gene expressions of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1. Tetradecanoylphorbol Acetate 223-254 matrix metallopeptidase 9 Homo sapiens 125-151 21925496-3 2011 The present study aimed to investigate the modulating effects of cilostazol on monocyte invasion and the gene expressions of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1. Tetradecanoylphorbol Acetate 256-259 matrix metallopeptidase 9 Homo sapiens 125-151 21871883-5 2011 In this study we investigated the effect of A771726, the active metabolite of leflunomide, on expression of CD147 and on the gelatinolytic activity of MMP-2 and MMP-9 in phorbol myristate acetate (PMA) differentiated THP-1 cells. Tetradecanoylphorbol Acetate 170-195 matrix metallopeptidase 9 Homo sapiens 161-166 21805048-7 2011 Results showed that the expression of MMP-9 and cell invasion in response to TPA was increased, whereas TPA-induced MMP-9 expression and cell invasion was decreased by RCE. Tetradecanoylphorbol Acetate 77-80 matrix metallopeptidase 9 Homo sapiens 38-43 21805048-0 2011 Radix clematidis extract inhibits TPA-induced MMP-9 expression by suppressing NF-kappaB activation in MCF-7 human breast cancer cells. Tetradecanoylphorbol Acetate 34-37 matrix metallopeptidase 9 Homo sapiens 46-51 21805048-3 2011 The purpose of the present study was to investigate the effects of RCE on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. Tetradecanoylphorbol Acetate 74-111 matrix metallopeptidase 9 Homo sapiens 126-131 21805048-3 2011 The purpose of the present study was to investigate the effects of RCE on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. Tetradecanoylphorbol Acetate 113-116 matrix metallopeptidase 9 Homo sapiens 126-131 21805048-7 2011 Results showed that the expression of MMP-9 and cell invasion in response to TPA was increased, whereas TPA-induced MMP-9 expression and cell invasion was decreased by RCE. Tetradecanoylphorbol Acetate 104-107 matrix metallopeptidase 9 Homo sapiens 116-121 21805048-9 2011 Thus, RCE is a potent inhibitor of TPA-induced MMP-9 expression and markedly blocks the NF-kappaB pathway in MCF-7 cells. Tetradecanoylphorbol Acetate 35-38 matrix metallopeptidase 9 Homo sapiens 47-52 21737808-1 2011 BACKGROUND AND PURPOSE: Plasma matrix metalloproteinase-9 levels predict posttissue plasminogen activator (tPA) hemorrhage. Tetradecanoylphorbol Acetate 107-110 matrix metallopeptidase 9 Homo sapiens 31-57 21737808-3 2011 RESULTS: Matrix metalloproteinase-9 level decreased at 72 hours compared with baseline in MINOS (tPA, P=0.0022; non-tPA, P=0.0066) and was lower than in the non-MINOS comparison group at 24 hours (tPA, P<0.0001; non-tPA, P=0.0019). Tetradecanoylphorbol Acetate 97-100 matrix metallopeptidase 9 Homo sapiens 9-35 21737808-3 2011 RESULTS: Matrix metalloproteinase-9 level decreased at 72 hours compared with baseline in MINOS (tPA, P=0.0022; non-tPA, P=0.0066) and was lower than in the non-MINOS comparison group at 24 hours (tPA, P<0.0001; non-tPA, P=0.0019). Tetradecanoylphorbol Acetate 116-119 matrix metallopeptidase 9 Homo sapiens 9-35 21737808-3 2011 RESULTS: Matrix metalloproteinase-9 level decreased at 72 hours compared with baseline in MINOS (tPA, P=0.0022; non-tPA, P=0.0066) and was lower than in the non-MINOS comparison group at 24 hours (tPA, P<0.0001; non-tPA, P=0.0019). Tetradecanoylphorbol Acetate 116-119 matrix metallopeptidase 9 Homo sapiens 9-35 21737808-3 2011 RESULTS: Matrix metalloproteinase-9 level decreased at 72 hours compared with baseline in MINOS (tPA, P=0.0022; non-tPA, P=0.0066) and was lower than in the non-MINOS comparison group at 24 hours (tPA, P<0.0001; non-tPA, P=0.0019). Tetradecanoylphorbol Acetate 116-119 matrix metallopeptidase 9 Homo sapiens 9-35 21737808-4 2011 CONCLUSIONS: Lower plasma matrix metalloproteinase-9 was seen among tPA-treated subjects in the MINOS trial. Tetradecanoylphorbol Acetate 68-71 matrix metallopeptidase 9 Homo sapiens 26-52 21737808-5 2011 Combining minocycline with tPA may prevent the adverse consequences of thrombolytic therapy through suppression of matrix metalloproteinase-9 activity. Tetradecanoylphorbol Acetate 27-30 matrix metallopeptidase 9 Homo sapiens 115-141 21713380-0 2011 Inhibitory effect of phytoglycoprotein (38 kDa) on expression of matrix metalloproteinase-9 in 12-O-tetradecanoylphorbol-13-acetate-treated HepG2cells. Tetradecanoylphorbol Acetate 95-131 matrix metallopeptidase 9 Homo sapiens 65-91 21448567-6 2011 Simvastatin and atorvastatin, but not pravastatin, attenuated PMA-induced increases in MMP-9 levels (P < 0.05). Tetradecanoylphorbol Acetate 62-65 matrix metallopeptidase 9 Homo sapiens 87-92 21354279-0 2011 Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCalpha/ERK1/2-dependent matrix metalloproteinase-9 expression. Tetradecanoylphorbol Acetate 15-46 matrix metallopeptidase 9 Homo sapiens 135-161 21354279-4 2011 We found that piperine suppresses PMA-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB and AP-1 activation without changing the level of tissue inhibitor of metalloproteinase (TIMP)-1. Tetradecanoylphorbol Acetate 34-37 matrix metallopeptidase 9 Homo sapiens 47-73 21354279-4 2011 We found that piperine suppresses PMA-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB and AP-1 activation without changing the level of tissue inhibitor of metalloproteinase (TIMP)-1. Tetradecanoylphorbol Acetate 34-37 matrix metallopeptidase 9 Homo sapiens 75-80 21089054-5 2011 We found that acteoside suppresses phorbol-12-myristate-13-acetate (PMA)-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB activation. Tetradecanoylphorbol Acetate 68-71 matrix metallopeptidase 9 Homo sapiens 110-115 21089054-0 2011 Acteoside inhibits PMA-induced matrix metalloproteinase-9 expression via CaMK/ERK- and JNK/NF-kappaB-dependent signaling. Tetradecanoylphorbol Acetate 19-22 matrix metallopeptidase 9 Homo sapiens 31-57 21089054-5 2011 We found that acteoside suppresses phorbol-12-myristate-13-acetate (PMA)-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB activation. Tetradecanoylphorbol Acetate 35-66 matrix metallopeptidase 9 Homo sapiens 82-108 21089054-5 2011 We found that acteoside suppresses phorbol-12-myristate-13-acetate (PMA)-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB activation. Tetradecanoylphorbol Acetate 35-66 matrix metallopeptidase 9 Homo sapiens 110-115 21089054-5 2011 We found that acteoside suppresses phorbol-12-myristate-13-acetate (PMA)-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB activation. Tetradecanoylphorbol Acetate 68-71 matrix metallopeptidase 9 Homo sapiens 82-108 21295103-5 2011 The mechanism revealed that wogonin significantly inhibited the expression and activity of both endogenous and phorbol-12-myristate-13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) potentially associating with the suppression of translocation of protein kinase C (PKC) delta and phosphorylation of extracellular signal-regulated kinase (ERK1/2). Tetradecanoylphorbol Acetate 111-142 matrix metallopeptidase 9 Homo sapiens 157-183 21295103-5 2011 The mechanism revealed that wogonin significantly inhibited the expression and activity of both endogenous and phorbol-12-myristate-13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) potentially associating with the suppression of translocation of protein kinase C (PKC) delta and phosphorylation of extracellular signal-regulated kinase (ERK1/2). Tetradecanoylphorbol Acetate 111-142 matrix metallopeptidase 9 Homo sapiens 185-190 21295103-5 2011 The mechanism revealed that wogonin significantly inhibited the expression and activity of both endogenous and phorbol-12-myristate-13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) potentially associating with the suppression of translocation of protein kinase C (PKC) delta and phosphorylation of extracellular signal-regulated kinase (ERK1/2). Tetradecanoylphorbol Acetate 144-147 matrix metallopeptidase 9 Homo sapiens 157-183 21295103-5 2011 The mechanism revealed that wogonin significantly inhibited the expression and activity of both endogenous and phorbol-12-myristate-13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) potentially associating with the suppression of translocation of protein kinase C (PKC) delta and phosphorylation of extracellular signal-regulated kinase (ERK1/2). Tetradecanoylphorbol Acetate 144-147 matrix metallopeptidase 9 Homo sapiens 185-190 21262201-4 2011 MMP-9 expression and cell invasion in response to 12-O-tetradecanoylphorbol-13-acetate (TPA) was increased, whereas these inductions were muted by DHAvD. Tetradecanoylphorbol Acetate 50-86 matrix metallopeptidase 9 Homo sapiens 0-5 21262201-4 2011 MMP-9 expression and cell invasion in response to 12-O-tetradecanoylphorbol-13-acetate (TPA) was increased, whereas these inductions were muted by DHAvD. Tetradecanoylphorbol Acetate 88-91 matrix metallopeptidase 9 Homo sapiens 0-5 21262201-6 2011 The results indicate that DHAvD-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the MAPK/NF-kappaB and MAPK/AP-1 pathways in MCF-7 cells. Tetradecanoylphorbol Acetate 55-58 matrix metallopeptidase 9 Homo sapiens 67-72 21865725-6 2011 We also found that celastrol inhibited PMA-induced MMP-9 expression at both the mRNA and the protein levels, and the proteolytic activity of MMP-9 in MCF-7 cells. Tetradecanoylphorbol Acetate 39-42 matrix metallopeptidase 9 Homo sapiens 51-56 21039753-0 2011 Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cdelta/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages. Tetradecanoylphorbol Acetate 201-226 matrix metallopeptidase 9 Homo sapiens 82-108 21039753-3 2011 The aim of the present study was to explore whether artemisinin, a natural extract from Artemisia annua, could decrease EMMPRIN and MMP-9 expression in phorbol myristate acetate (PMA)-induced macrophages by regulating the protein kinase (PK) Cdelta/c-Jun N-terminal kinase (JNK)/p38/extracellular signal-regulated kinase (ERK) pathway. Tetradecanoylphorbol Acetate 179-182 matrix metallopeptidase 9 Homo sapiens 132-137 21625419-5 2011 Human brain microvascular endothelial cells were treated with a combination of phorbol 12-myristate 13-acetate (PMA), a carcinogen documented to increase MMP-9 and COX-2 through NF-kappaB, and several naturally occurring flavonoids. Tetradecanoylphorbol Acetate 79-110 matrix metallopeptidase 9 Homo sapiens 154-159 21625419-5 2011 Human brain microvascular endothelial cells were treated with a combination of phorbol 12-myristate 13-acetate (PMA), a carcinogen documented to increase MMP-9 and COX-2 through NF-kappaB, and several naturally occurring flavonoids. Tetradecanoylphorbol Acetate 112-115 matrix metallopeptidase 9 Homo sapiens 154-159 22096365-6 2011 Inversely, PMA-induced matrix-metalloproteinase-9 (MMP-9) gene expression and protein secretion were abrogated in the presence of 2-DG, and this can be partially explained by reduced nuclear factor-kappaB signaling. Tetradecanoylphorbol Acetate 11-14 matrix metallopeptidase 9 Homo sapiens 23-49 22096365-6 2011 Inversely, PMA-induced matrix-metalloproteinase-9 (MMP-9) gene expression and protein secretion were abrogated in the presence of 2-DG, and this can be partially explained by reduced nuclear factor-kappaB signaling. Tetradecanoylphorbol Acetate 11-14 matrix metallopeptidase 9 Homo sapiens 51-56 20718733-5 2010 The suppressive effects of 6-shogaol on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) gelatinolytic activity and nuclear factor-kappaB (NF-kappaB) activation were further determined. Tetradecanoylphorbol Acetate 40-71 matrix metallopeptidase 9 Homo sapiens 86-112 20718733-5 2010 The suppressive effects of 6-shogaol on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) gelatinolytic activity and nuclear factor-kappaB (NF-kappaB) activation were further determined. Tetradecanoylphorbol Acetate 40-71 matrix metallopeptidase 9 Homo sapiens 114-119 20718733-5 2010 The suppressive effects of 6-shogaol on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) gelatinolytic activity and nuclear factor-kappaB (NF-kappaB) activation were further determined. Tetradecanoylphorbol Acetate 73-76 matrix metallopeptidase 9 Homo sapiens 86-112 20718733-5 2010 The suppressive effects of 6-shogaol on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) gelatinolytic activity and nuclear factor-kappaB (NF-kappaB) activation were further determined. Tetradecanoylphorbol Acetate 73-76 matrix metallopeptidase 9 Homo sapiens 114-119 20131957-0 2010 Hyul-Tong-Ryung suppresses PMA-induced MMP-9 expression by inhibiting AP-1-mediated gene expression via ERK 1/2 signaling pathway in MCF-7 human breast cancer cells. Tetradecanoylphorbol Acetate 27-30 matrix metallopeptidase 9 Homo sapiens 39-44 20131957-1 2010 Our previous study has demonstrated that the methanol extract of Hyul-Tong-Ryung (HM) specifically suppresses the phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) production through the inhibition of MMP-9 mRNA expression in MCF-7 human breast carcinoma cells. Tetradecanoylphorbol Acetate 114-145 matrix metallopeptidase 9 Homo sapiens 188-193 20131957-1 2010 Our previous study has demonstrated that the methanol extract of Hyul-Tong-Ryung (HM) specifically suppresses the phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) production through the inhibition of MMP-9 mRNA expression in MCF-7 human breast carcinoma cells. Tetradecanoylphorbol Acetate 114-145 matrix metallopeptidase 9 Homo sapiens 232-237 20131957-1 2010 Our previous study has demonstrated that the methanol extract of Hyul-Tong-Ryung (HM) specifically suppresses the phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) production through the inhibition of MMP-9 mRNA expression in MCF-7 human breast carcinoma cells. Tetradecanoylphorbol Acetate 147-150 matrix metallopeptidase 9 Homo sapiens 188-193 20131957-1 2010 Our previous study has demonstrated that the methanol extract of Hyul-Tong-Ryung (HM) specifically suppresses the phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) production through the inhibition of MMP-9 mRNA expression in MCF-7 human breast carcinoma cells. Tetradecanoylphorbol Acetate 147-150 matrix metallopeptidase 9 Homo sapiens 232-237 20131957-7 2010 These results indicate that HM inhibits PMA-induced MMP-9 expression by blocking the activation of activator protein-1 (AP-1) via extracellular signal regulated kinase 1/2 (ERK 1/2) signaling pathway. Tetradecanoylphorbol Acetate 40-43 matrix metallopeptidase 9 Homo sapiens 52-57 21124749-6 2010 We next found that propranolol dose-dependently inhibited induction of the key extracellular matrix-degrading and blood-brain barrier disrupting enzyme matrix metalloproteinase- 9 (MMP-9) by phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 191-222 matrix metallopeptidase 9 Homo sapiens 152-179 21124749-6 2010 We next found that propranolol dose-dependently inhibited induction of the key extracellular matrix-degrading and blood-brain barrier disrupting enzyme matrix metalloproteinase- 9 (MMP-9) by phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 191-222 matrix metallopeptidase 9 Homo sapiens 181-186 21124749-6 2010 We next found that propranolol dose-dependently inhibited induction of the key extracellular matrix-degrading and blood-brain barrier disrupting enzyme matrix metalloproteinase- 9 (MMP-9) by phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 224-227 matrix metallopeptidase 9 Homo sapiens 152-179 21124749-6 2010 We next found that propranolol dose-dependently inhibited induction of the key extracellular matrix-degrading and blood-brain barrier disrupting enzyme matrix metalloproteinase- 9 (MMP-9) by phorbol 12-myristate 13-acetate (PMA). Tetradecanoylphorbol Acetate 224-227 matrix metallopeptidase 9 Homo sapiens 181-186 20458747-0 2010 12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expression. Tetradecanoylphorbol Acetate 0-36 matrix metallopeptidase 9 Homo sapiens 138-143 20458747-1 2010 An increase in MMP-9 gene expression and enzyme activity with stimulating the migration of GBM8401 glioma cells via wound healing assay by 12-O-tetradecanoylphorbol-13-acetate (TPA) was detected in glioblastoma cells GBM8401. Tetradecanoylphorbol Acetate 139-175 matrix metallopeptidase 9 Homo sapiens 15-20 20458747-1 2010 An increase in MMP-9 gene expression and enzyme activity with stimulating the migration of GBM8401 glioma cells via wound healing assay by 12-O-tetradecanoylphorbol-13-acetate (TPA) was detected in glioblastoma cells GBM8401. Tetradecanoylphorbol Acetate 177-180 matrix metallopeptidase 9 Homo sapiens 15-20 20458747-3 2010 Activation of extracellular signal-regulated kinase (ERK) and c-Jun-N-terminal kinase (JNK) by TPA was identified, and TPA-induced migration and MMP-9 activity was significantly blocked by ERK inhibitor PD98059 and U0126, but not JNK inhibitor SP600125. Tetradecanoylphorbol Acetate 119-122 matrix metallopeptidase 9 Homo sapiens 145-150 20458747-4 2010 Activation of NF-kappaB protein p65 nuclear translocation and IkappaBalpha protein phosphorylation with increased NF-kappaB-directed luciferase activity by TPA were observed, and these were blocked by the PD98059 and IkB inhibitor BAY117082 accompanied by reducing migration and MMP-9 activity induced by TPA in GBM8401 cells. Tetradecanoylphorbol Acetate 156-159 matrix metallopeptidase 9 Homo sapiens 279-284 20458747-4 2010 Activation of NF-kappaB protein p65 nuclear translocation and IkappaBalpha protein phosphorylation with increased NF-kappaB-directed luciferase activity by TPA were observed, and these were blocked by the PD98059 and IkB inhibitor BAY117082 accompanied by reducing migration and MMP-9 activity induced by TPA in GBM8401 cells. Tetradecanoylphorbol Acetate 305-308 matrix metallopeptidase 9 Homo sapiens 279-284 20458747-5 2010 Transfection of GBM8401 cells with PKCalpha siRNA specifically reduced PKCalpha protein expression with blocking TPA-induced MMP-9 activation and migration. Tetradecanoylphorbol Acetate 113-116 matrix metallopeptidase 9 Homo sapiens 125-130 21047770-4 2010 To understand the underlying mechanism, we showed that CADPE significantly inhibited phorbol 12-myristate 13-acetate (PMA)-induced increases in MMP-9 expression and activity in a dose-dependent manner. Tetradecanoylphorbol Acetate 85-116 matrix metallopeptidase 9 Homo sapiens 144-149 21047770-4 2010 To understand the underlying mechanism, we showed that CADPE significantly inhibited phorbol 12-myristate 13-acetate (PMA)-induced increases in MMP-9 expression and activity in a dose-dependent manner. Tetradecanoylphorbol Acetate 118-121 matrix metallopeptidase 9 Homo sapiens 144-149 20696233-7 2010 Furthermore, butein repressed the expression of VEGF and MMP-9 induced by treatment with tumor necrosis factor-alpha and phorbol-12-myristate-13-acetate. Tetradecanoylphorbol Acetate 121-152 matrix metallopeptidase 9 Homo sapiens 57-62 20652762-0 2010 Alpha-mangostin suppresses phorbol 12-myristate 13-acetate-induced MMP-2/MMP-9 expressions via alphavbeta3 integrin/FAK/ERK and NF-kappaB signaling pathway in human lung adenocarcinoma A549 cells. Tetradecanoylphorbol Acetate 27-58 matrix metallopeptidase 9 Homo sapiens 73-78 20652762-1 2010 The purpose of this study is to investigate the anti-metastatic effect of alpha-mangostin on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in A549 human lung adenocarcinoma cells. Tetradecanoylphorbol Acetate 93-124 matrix metallopeptidase 9 Homo sapiens 178-204 20652762-1 2010 The purpose of this study is to investigate the anti-metastatic effect of alpha-mangostin on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in A549 human lung adenocarcinoma cells. Tetradecanoylphorbol Acetate 93-124 matrix metallopeptidase 9 Homo sapiens 206-211 20652762-1 2010 The purpose of this study is to investigate the anti-metastatic effect of alpha-mangostin on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in A549 human lung adenocarcinoma cells. Tetradecanoylphorbol Acetate 126-129 matrix metallopeptidase 9 Homo sapiens 178-204 20652762-1 2010 The purpose of this study is to investigate the anti-metastatic effect of alpha-mangostin on phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in A549 human lung adenocarcinoma cells. Tetradecanoylphorbol Acetate 126-129 matrix metallopeptidase 9 Homo sapiens 206-211 20590612-0 2010 Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced/extracellular signal-regulated kinase/activator protein-1. Tetradecanoylphorbol Acetate 174-205 matrix metallopeptidase 9 Homo sapiens 73-99 20590612-6 2010 In these cells, metformin also suppressed phorbol-12-myristate-13-acetate (PMA)-enhanced levels of matrix metalloproteinases-9 (MMP-9) protein, mRNA and transcription activity through suppression of activator protein-1 (AP-1) activation. Tetradecanoylphorbol Acetate 42-73 matrix metallopeptidase 9 Homo sapiens 99-126 20590612-6 2010 In these cells, metformin also suppressed phorbol-12-myristate-13-acetate (PMA)-enhanced levels of matrix metalloproteinases-9 (MMP-9) protein, mRNA and transcription activity through suppression of activator protein-1 (AP-1) activation. Tetradecanoylphorbol Acetate 42-73 matrix metallopeptidase 9 Homo sapiens 128-133 20590612-6 2010 In these cells, metformin also suppressed phorbol-12-myristate-13-acetate (PMA)-enhanced levels of matrix metalloproteinases-9 (MMP-9) protein, mRNA and transcription activity through suppression of activator protein-1 (AP-1) activation. Tetradecanoylphorbol Acetate 75-78 matrix metallopeptidase 9 Homo sapiens 99-126 20590612-6 2010 In these cells, metformin also suppressed phorbol-12-myristate-13-acetate (PMA)-enhanced levels of matrix metalloproteinases-9 (MMP-9) protein, mRNA and transcription activity through suppression of activator protein-1 (AP-1) activation. Tetradecanoylphorbol Acetate 75-78 matrix metallopeptidase 9 Homo sapiens 128-133 19943262-3 2010 Bergamottin reduced phorbol-12-myristate-13-acetate (PMA)-induced activation of MMP-9 and MMP-2 and further inhibited cell invasion and migration. Tetradecanoylphorbol Acetate 20-51 matrix metallopeptidase 9 Homo sapiens 80-85 19943262-3 2010 Bergamottin reduced phorbol-12-myristate-13-acetate (PMA)-induced activation of MMP-9 and MMP-2 and further inhibited cell invasion and migration. Tetradecanoylphorbol Acetate 53-56 matrix metallopeptidase 9 Homo sapiens 80-85 20514473-0 2010 Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by apigenin via the inhibition of p38 mitogen-activated protein kinase-dependent matrix metalloproteinase-9 expression. Tetradecanoylphorbol Acetate 15-46 matrix metallopeptidase 9 Homo sapiens 156-182 20514473-3 2010 We found that apigenin markedly inhibits the phorbol-12-myristate-13-acetate (PMA)-induced increase in MMP-9 expression and activity in several cancer cell lines. Tetradecanoylphorbol Acetate 45-76 matrix metallopeptidase 9 Homo sapiens 103-108 20514473-3 2010 We found that apigenin markedly inhibits the phorbol-12-myristate-13-acetate (PMA)-induced increase in MMP-9 expression and activity in several cancer cell lines. Tetradecanoylphorbol Acetate 78-81 matrix metallopeptidase 9 Homo sapiens 103-108 20514473-6 2010 We found that apigenin could inhibit PMA-induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), which was involved in the down-regulation of the expression of matrix metalloproteinase-9 (MMP-9) at mRNA levels. Tetradecanoylphorbol Acetate 37-40 matrix metallopeptidase 9 Homo sapiens 180-206 20514473-6 2010 We found that apigenin could inhibit PMA-induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), which was involved in the down-regulation of the expression of matrix metalloproteinase-9 (MMP-9) at mRNA levels. Tetradecanoylphorbol Acetate 37-40 matrix metallopeptidase 9 Homo sapiens 208-213 20152819-4 2010 DHA reduced PMA-induced activation of MMP-9 and MMP-2 and further inhibited cell invasion and migration. Tetradecanoylphorbol Acetate 12-15 matrix metallopeptidase 9 Homo sapiens 38-43 20152819-5 2010 DHA suppressed PMA-enhanced expression of MMP-9 protein, mRNA, and transcriptional activity through suppressing NF-kappaB and AP-1 activation without changing the level of tissue inhibitor of metalloproteinase (TIMP)-1. Tetradecanoylphorbol Acetate 15-18 matrix metallopeptidase 9 Homo sapiens 42-47 20152819-7 2010 DHA-inhibited PMA-induced NF-kappaB and c-Jun nuclear translocation, which are upstream of PMA-induced MMP-9 expression and invasion. Tetradecanoylphorbol Acetate 14-17 matrix metallopeptidase 9 Homo sapiens 103-108 20152819-7 2010 DHA-inhibited PMA-induced NF-kappaB and c-Jun nuclear translocation, which are upstream of PMA-induced MMP-9 expression and invasion. Tetradecanoylphorbol Acetate 91-94 matrix metallopeptidase 9 Homo sapiens 103-108 20486934-6 2010 The mumbaistatin analog significantly inhibited the phorbol 12-myristate 13-acetate (PMA)-induced matrix-metalloproteinase (MMP)-9 secretion and gene expression as assessed by zymography and RT-PCR. Tetradecanoylphorbol Acetate 52-83 matrix metallopeptidase 9 Homo sapiens 98-130 20486934-6 2010 The mumbaistatin analog significantly inhibited the phorbol 12-myristate 13-acetate (PMA)-induced matrix-metalloproteinase (MMP)-9 secretion and gene expression as assessed by zymography and RT-PCR. Tetradecanoylphorbol Acetate 85-88 matrix metallopeptidase 9 Homo sapiens 98-130 20188714-4 2010 In addition, gelatin zymography showed that glycitein inhibited the PMA-induced MMP-9 secretion in U87MG cells. Tetradecanoylphorbol Acetate 68-71 matrix metallopeptidase 9 Homo sapiens 80-85 20188714-6 2010 In support of this, treatment of MMP-3- or MMP-9-specific inhibitor significantly suppressed PMA-induced invasion of glioma cells. Tetradecanoylphorbol Acetate 93-96 matrix metallopeptidase 9 Homo sapiens 43-48 20138977-3 2010 First, we suggest that the expression of MMP-9 by TPA involves phosphorylation of IKK, p38, and PKC in hepG2. Tetradecanoylphorbol Acetate 50-53 matrix metallopeptidase 9 Homo sapiens 41-46 20138977-5 2010 Hesperidin significantly suppressed the TPA-induced the mRNA level of MMP-9. Tetradecanoylphorbol Acetate 40-43 matrix metallopeptidase 9 Homo sapiens 70-75 20126997-8 2010 MMP-9 was stimulated by phorbol 12-myristate 13-acetate in HeLa cells and enhanced in DoTc2-4510. Tetradecanoylphorbol Acetate 24-55 matrix metallopeptidase 9 Homo sapiens 0-5 20082219-2 2010 In this study, we examined the inhibitory effect of bee venom (BV) and its major peptides, melittin and apamin, on PMA-induced invasion induced by MMP-9 expression in Caki-1 renal cancer cells. Tetradecanoylphorbol Acetate 115-118 matrix metallopeptidase 9 Homo sapiens 147-152 19969058-10 2010 We confirmed that PMA-induced MMP-9 activity was significantly decreased by melittin, but not by apamin and phospholipase A(2). Tetradecanoylphorbol Acetate 18-21 matrix metallopeptidase 9 Homo sapiens 30-35 19969058-12 2010 CONCLUSION: Bee venom inhibits PMA-induced MMP-9 expression and activity by inhibition of NF-kappaB via p38 MAPK and JNK signaling pathways in MCF-7 cells. Tetradecanoylphorbol Acetate 31-34 matrix metallopeptidase 9 Homo sapiens 43-48 20043135-0 2010 Cordycepin inhibits TPA-induced matrix metalloproteinase-9 expression by suppressing the MAPK/AP-1 pathway in MCF-7 human breast cancer cells. Tetradecanoylphorbol Acetate 20-23 matrix metallopeptidase 9 Homo sapiens 32-58 20043135-9 2010 Cordycepin inhibits TPA-induced MMP-9 expression and cell invasion by suppressing AP-1 activation. Tetradecanoylphorbol Acetate 20-23 matrix metallopeptidase 9 Homo sapiens 32-37 20043135-11 2010 Cordycepin is a potent inhibitor of TPA-induced MMP-9 expression and blocks strongly the ability of AP-1 activation via MAPK signaling pathway in MCF-7 cells. Tetradecanoylphorbol Acetate 36-39 matrix metallopeptidase 9 Homo sapiens 48-53 19784811-9 2010 In the presence of the RXR agonists 9-cis retinoic acid or SR11237, PMA-induced THP-1 cells became less adherent, showed decreased macrophage-like morphological changes, decreased cell surface antigen CD11b and CD36 expression, and down regulated the phagocytosis of latex beads and the production of TNF-alpha and MMP-9. Tetradecanoylphorbol Acetate 68-71 matrix metallopeptidase 9 Homo sapiens 315-320 20492173-0 2010 alpha-Mangostin, a novel dietary xanthone, suppresses TPA-mediated MMP-2 and MMP-9 expressions through the ERK signaling pathway in MCF-7 human breast adenocarcinoma cells. Tetradecanoylphorbol Acetate 54-57 matrix metallopeptidase 9 Homo sapiens 77-82 20492173-1 2010 This study first investigates the anti-metastatic effect of alpha-mangostin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in human breast adenocarcinoma cells, MCF-7. Tetradecanoylphorbol Acetate 79-115 matrix metallopeptidase 9 Homo sapiens 169-195 20492173-1 2010 This study first investigates the anti-metastatic effect of alpha-mangostin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in human breast adenocarcinoma cells, MCF-7. Tetradecanoylphorbol Acetate 79-115 matrix metallopeptidase 9 Homo sapiens 197-202 20492173-1 2010 This study first investigates the anti-metastatic effect of alpha-mangostin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expressions in human breast adenocarcinoma cells, MCF-7. Tetradecanoylphorbol Acetate 117-120 matrix metallopeptidase 9 Homo sapiens 197-202 20492173-3 2010 Data also showed alpha-mangostin could inhibit the activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) involved in the downregulation the enzyme activities, protein, and messenger RNA levels of MMP-2 and MMP-9 induced by TPA. Tetradecanoylphorbol Acetate 238-241 matrix metallopeptidase 9 Homo sapiens 221-226 20492173-6 2010 Further, the treatment of specific inhibitor for ERK (U0126) to MCF-7 cells could inhibit TPA-induced MMP-2 and MMP-9 expressions along with an inhibition on cell invasion and migration. Tetradecanoylphorbol Acetate 90-93 matrix metallopeptidase 9 Homo sapiens 112-117 19804834-1 2010 In the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation, an increase in the migration/invasion of U87 glioblastoma cells was detected by a wound healing assay, transwell analysis, and spheroid formation assay by inducing matrix metalloproteinase-9 (MMP-9) enzyme activity via a gelatin zymographic analysis. Tetradecanoylphorbol Acetate 19-55 matrix metallopeptidase 9 Homo sapiens 239-265 19804834-1 2010 In the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation, an increase in the migration/invasion of U87 glioblastoma cells was detected by a wound healing assay, transwell analysis, and spheroid formation assay by inducing matrix metalloproteinase-9 (MMP-9) enzyme activity via a gelatin zymographic analysis. Tetradecanoylphorbol Acetate 19-55 matrix metallopeptidase 9 Homo sapiens 267-272 19804834-1 2010 In the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation, an increase in the migration/invasion of U87 glioblastoma cells was detected by a wound healing assay, transwell analysis, and spheroid formation assay by inducing matrix metalloproteinase-9 (MMP-9) enzyme activity via a gelatin zymographic analysis. Tetradecanoylphorbol Acetate 57-60 matrix metallopeptidase 9 Homo sapiens 239-265 19804834-1 2010 In the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation, an increase in the migration/invasion of U87 glioblastoma cells was detected by a wound healing assay, transwell analysis, and spheroid formation assay by inducing matrix metalloproteinase-9 (MMP-9) enzyme activity via a gelatin zymographic analysis. Tetradecanoylphorbol Acetate 57-60 matrix metallopeptidase 9 Homo sapiens 267-272 19804834-3 2010 Data from the pharmacological studies using specific chemical inhibitors showed that activation of protein kinase C (PKC) and extracellular signal-regulated kinases (ERKs) was involved in TPA-induced migration/invasion, COX-2 protein expression, and MMP-9 activation. Tetradecanoylphorbol Acetate 188-191 matrix metallopeptidase 9 Homo sapiens 250-255 19804834-6 2010 Additionally, the natural flavonoids quercetin (QE), baicalein (BE), and myricetin (ME) effectively blocked TPA-induced migration/invasion while simultaneously inhibiting COX-2/PGE(2) production, MMP-9 enzyme activity, and peroxide production in U87 cells. Tetradecanoylphorbol Acetate 108-111 matrix metallopeptidase 9 Homo sapiens 196-201 19715751-0 2009 Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast cancer cells. Tetradecanoylphorbol Acetate 19-22 matrix metallopeptidase 9 Homo sapiens 31-36 19715751-2 2009 In a previous study, we reported that silibinin suppresses TPA-induced MMP-9 expression through the Raf/MEK/ERK pathway. Tetradecanoylphorbol Acetate 59-62 matrix metallopeptidase 9 Homo sapiens 71-76 19715751-3 2009 AIMS OF THE STUDY: Herein we determined the co-relationship between MMP-9 and COX-2, as well as the effect of silibinin on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 and COX-2 expression in the human breast cancer cells, MCF-7 and MDA-MB231. Tetradecanoylphorbol Acetate 123-160 matrix metallopeptidase 9 Homo sapiens 175-180 19715751-7 2009 RESULTS: The expression of MMP-9 and COX-2 in response to TPA was increased, whereas TPA-induced MMP-9 and COX-2 expression was decreased by silibinin. Tetradecanoylphorbol Acetate 58-61 matrix metallopeptidase 9 Homo sapiens 27-32 19715751-7 2009 RESULTS: The expression of MMP-9 and COX-2 in response to TPA was increased, whereas TPA-induced MMP-9 and COX-2 expression was decreased by silibinin. Tetradecanoylphorbol Acetate 85-88 matrix metallopeptidase 9 Homo sapiens 97-102 19715751-8 2009 Our results showed that TPA-induced MMP-9 expression was inhibited by celecoxib in a dose-dependent fashion, but not MMP-1-expression. Tetradecanoylphorbol Acetate 24-27 matrix metallopeptidase 9 Homo sapiens 36-41 19715751-10 2009 In contrast, TPA-induced MMP-9 and COX-2 expression was decreased by UO126 (MEK 1/2 inhibitor). Tetradecanoylphorbol Acetate 13-16 matrix metallopeptidase 9 Homo sapiens 25-30 19715751-11 2009 CONCLUSION: Silibinin down-regulates TPA-induced MMP-9 expression through inhibition of COX-2 expression in breast cancer cells. Tetradecanoylphorbol Acetate 37-40 matrix metallopeptidase 9 Homo sapiens 49-54 19828892-3 2009 We tested the hypothesis that cPLA(2)alpha also regulates MMP-9 induction by Fusobacterium nucleatum and by phorbol 12-myristate-13-acetate (PMA) in gingival epithelial cells. Tetradecanoylphorbol Acetate 108-139 matrix metallopeptidase 9 Homo sapiens 58-63 19467330-7 2009 Propranolol significantly reduced MMP-9 secretion upon treatment with the tumor-promoting agent phorbol 12-myristate 13-acetate, while secretion of MMP-2 remained unaffected. Tetradecanoylphorbol Acetate 96-127 matrix metallopeptidase 9 Homo sapiens 34-39 19687351-8 2009 EXP3179 also inhibited (P<0.05) phorbol myristate acetate-stimulated MMP-9 secretion. Tetradecanoylphorbol Acetate 35-60 matrix metallopeptidase 9 Homo sapiens 72-77 19420332-3 2009 Changes of expression of MMP-2 and MMP-9 of fibroblasts after the simulation of a standard PKC activator, 2-O-tetradecanoyl-phorbol-13-acetate (TPA), were studied. Tetradecanoylphorbol Acetate 144-147 matrix metallopeptidase 9 Homo sapiens 35-40 19420332-7 2009 TPA stimulated the expression of MMP-2 and MMP-9 by pterygium fibroblasts isolated from early-stage specimens in a dose-dependent manner. Tetradecanoylphorbol Acetate 0-3 matrix metallopeptidase 9 Homo sapiens 43-48 19420016-0 2009 Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells. Tetradecanoylphorbol Acetate 28-31 matrix metallopeptidase 9 Homo sapiens 61-87 19420016-2 2009 We investigated the inhibitory effect of kalopanaxsaponin A (KPS-A) on cell invasion and MMP-9 activation in phorbol 12-myristate 13-acetate (PMA)-treated MCF-7 human breast cancer cells. Tetradecanoylphorbol Acetate 142-145 matrix metallopeptidase 9 Homo sapiens 89-94 19420016-4 2009 PMA-induced cell invasion was blocked in the presence of a primary antibody of MMP-9, and KPS-A suppressed the increased expression and/or secretion of MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1. Tetradecanoylphorbol Acetate 0-3 matrix metallopeptidase 9 Homo sapiens 79-84 19420016-5 2009 Using specific inhibitors, we confirmed that PMA-induced cell invasion and MMP-9 expression is primarily regulated by nuclear factor-kappa B (NF-kappaB) activation via phosphatidylinositol 3-kinase (PI3K)/Akt and activator protein-1 (AP-1) activation via extracellular signal-regulated kinase (ERK)1/2. Tetradecanoylphorbol Acetate 45-48 matrix metallopeptidase 9 Homo sapiens 75-80 19420016-7 2009 Treatment with the protein kinase C (PKC)delta inhibitor rottlerin caused a marked decrease in PMA-induced MMP-9 secretion and cell invasion, as well as ERK/AP-1 activation, and KPS-A reduced PMA-induced membrane localization of PKCdelta. Tetradecanoylphorbol Acetate 95-98 matrix metallopeptidase 9 Homo sapiens 107-112 19420016-9 2009 These results suggest that KPS-A inhibits PMA-induced invasion by reducing MMP-9 activation, mainly via the PI3K/Akt/NF-kappaB and PKCdelta/ERK/AP-1 pathways in MCF-7 cells and blocks tumor growth and MMP-9-mediated invasiveness in mice with breast carcinoma. Tetradecanoylphorbol Acetate 42-45 matrix metallopeptidase 9 Homo sapiens 75-80 19420016-9 2009 These results suggest that KPS-A inhibits PMA-induced invasion by reducing MMP-9 activation, mainly via the PI3K/Akt/NF-kappaB and PKCdelta/ERK/AP-1 pathways in MCF-7 cells and blocks tumor growth and MMP-9-mediated invasiveness in mice with breast carcinoma. Tetradecanoylphorbol Acetate 42-45 matrix metallopeptidase 9 Homo sapiens 201-206 19447859-4 2009 Increase in the enzyme activity, protein and messenger RNA levels of matrix metalloproteinase (MMP)-9 were observed in TPA-treated HepG(2) cells, and these were blocked by pterostilbene. Tetradecanoylphorbol Acetate 119-122 matrix metallopeptidase 9 Homo sapiens 69-101 19422227-4 2009 Phorbol-12-myristate-13-acetate (PMA)-induced invasion and matrix metalloproteinase (MMP)-9 expression levels of HepG2 cells were reduced by GLE treatment in a dose-dependent manner. Tetradecanoylphorbol Acetate 33-36 matrix metallopeptidase 9 Homo sapiens 59-91 19205902-6 2009 PMA treatment in THP-1 cells resulted in increased expression of matrix metalloproteinase (MMP) 9 and vascular endothelial growth factor receptor 1 (VEGFR1), whereas inhibition of ATP7A resulted in suppression of PMA-induced expression of VEGFR1, but not MMP9. Tetradecanoylphorbol Acetate 0-3 matrix metallopeptidase 9 Homo sapiens 65-97 19205902-6 2009 PMA treatment in THP-1 cells resulted in increased expression of matrix metalloproteinase (MMP) 9 and vascular endothelial growth factor receptor 1 (VEGFR1), whereas inhibition of ATP7A resulted in suppression of PMA-induced expression of VEGFR1, but not MMP9. Tetradecanoylphorbol Acetate 0-3 matrix metallopeptidase 9 Homo sapiens 255-259 19679626-8 2009 Zymography revealed MMP-2 and phorbol 12-myristate 13-acetate-induced MMP-9 secretion. Tetradecanoylphorbol Acetate 30-61 matrix metallopeptidase 9 Homo sapiens 70-75 19181503-0 2009 Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells. Tetradecanoylphorbol Acetate 19-22 matrix metallopeptidase 9 Homo sapiens 31-36 19181503-2 2009 Herein, we investigated the effect of silibinin, a major constituent (flavanolignan) of the fruits of Silybum marianum, on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 and VEGF expression in MCF-7 human breast cancer cells. Tetradecanoylphorbol Acetate 123-160 matrix metallopeptidase 9 Homo sapiens 175-180 19181503-3 2009 The expression of MMP-9 and VEGF in response to TPA was increased, whereas TPA-induced MMP-9 and VEGF expression was decreased by silibinin. Tetradecanoylphorbol Acetate 48-51 matrix metallopeptidase 9 Homo sapiens 18-23 19181503-3 2009 The expression of MMP-9 and VEGF in response to TPA was increased, whereas TPA-induced MMP-9 and VEGF expression was decreased by silibinin. Tetradecanoylphorbol Acetate 75-78 matrix metallopeptidase 9 Homo sapiens 87-92 19181503-4 2009 To investigate the regulatory mechanism of silibinin on TPA-induced MMP-9 and VEGF expression, we pretreated cells with various inhibitors, such as UO126 (MEK1/2 inhibitor), SP600125 (JNK inhibitor), and SB203580 (p38 inhibitor). Tetradecanoylphorbol Acetate 56-59 matrix metallopeptidase 9 Homo sapiens 68-73 19181503-5 2009 Interestingly, TPA-induced MMP-9 expression was significantly inhibited by UO126, but not by SP600125 and SB203580. Tetradecanoylphorbol Acetate 15-18 matrix metallopeptidase 9 Homo sapiens 27-32 19181503-10 2009 Taken together, we suggest that the inhibition of TPA-induced MMP-9 and VEGF expression by silibinin is mediated by the suppression of the Raf/MEK/ERK pathway in MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 50-53 matrix metallopeptidase 9 Homo sapiens 62-67 19375915-5 2009 Apparently, phorbol myristate acetate (PMA) stimulated expressions of ERK, JNK and p38 were altered in the presence of potent tumour inducer, phorbol myristate acetate QAGlc, suggesting their suppression also contributes to QAGlc-mediated inhibition of MMP-9 and MMP-2. Tetradecanoylphorbol Acetate 12-37 matrix metallopeptidase 9 Homo sapiens 253-258 19375915-5 2009 Apparently, phorbol myristate acetate (PMA) stimulated expressions of ERK, JNK and p38 were altered in the presence of potent tumour inducer, phorbol myristate acetate QAGlc, suggesting their suppression also contributes to QAGlc-mediated inhibition of MMP-9 and MMP-2. Tetradecanoylphorbol Acetate 39-42 matrix metallopeptidase 9 Homo sapiens 253-258 19375915-5 2009 Apparently, phorbol myristate acetate (PMA) stimulated expressions of ERK, JNK and p38 were altered in the presence of potent tumour inducer, phorbol myristate acetate QAGlc, suggesting their suppression also contributes to QAGlc-mediated inhibition of MMP-9 and MMP-2. Tetradecanoylphorbol Acetate 142-167 matrix metallopeptidase 9 Homo sapiens 253-258 19130490-0 2009 Molecular mechanisms of nitric oxide-dependent inhibition of TPA-induced matrix metalloproteinase-9 (MMP-9) in MCF-7 cells. Tetradecanoylphorbol Acetate 61-64 matrix metallopeptidase 9 Homo sapiens 73-99 19130490-0 2009 Molecular mechanisms of nitric oxide-dependent inhibition of TPA-induced matrix metalloproteinase-9 (MMP-9) in MCF-7 cells. Tetradecanoylphorbol Acetate 61-64 matrix metallopeptidase 9 Homo sapiens 101-106 19130490-2 2009 We investigated the modulatory effects of nitric oxide (NO) on the 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced MMP-9 expression in MCF-7 cells. Tetradecanoylphorbol Acetate 67-103 matrix metallopeptidase 9 Homo sapiens 118-123 19130490-2 2009 We investigated the modulatory effects of nitric oxide (NO) on the 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced MMP-9 expression in MCF-7 cells. Tetradecanoylphorbol Acetate 105-108 matrix metallopeptidase 9 Homo sapiens 118-123 19130490-3 2009 Different chemical NO donors inhibited the extracellular content of TPA-induced MMP-9 protein and MMP-9 activity as assessed by gelatin-zymography and ELISA, respectively. Tetradecanoylphorbol Acetate 68-71 matrix metallopeptidase 9 Homo sapiens 80-85 19130490-3 2009 Different chemical NO donors inhibited the extracellular content of TPA-induced MMP-9 protein and MMP-9 activity as assessed by gelatin-zymography and ELISA, respectively. Tetradecanoylphorbol Acetate 68-71 matrix metallopeptidase 9 Homo sapiens 98-103 19130490-7 2009 Using pharmacological inhibitors and small interfering (si)RNA we found that PKCdelta is indispensably involved in the TPA-triggered MMP-9 expression. Tetradecanoylphorbol Acetate 119-122 matrix metallopeptidase 9 Homo sapiens 133-138 19130490-8 2009 Concomitantly, the TPA-evoked increase in total PKC activity was strongly attenuated in the lysates from NO-treated MCF-7 cells, thus suggesting that NO attenuates TPA-triggered MMP-9 mainly through a direct inhibition of PKCdelta. Tetradecanoylphorbol Acetate 19-22 matrix metallopeptidase 9 Homo sapiens 178-183 19130490-8 2009 Concomitantly, the TPA-evoked increase in total PKC activity was strongly attenuated in the lysates from NO-treated MCF-7 cells, thus suggesting that NO attenuates TPA-triggered MMP-9 mainly through a direct inhibition of PKCdelta. Tetradecanoylphorbol Acetate 164-167 matrix metallopeptidase 9 Homo sapiens 178-183 19360311-9 2009 The first group characterized by low basal MMP-9 secretion fell into three different categories of susceptibility to PMA induction of MMP-9 expression: resistant, moderately susceptible and highly susceptible. Tetradecanoylphorbol Acetate 117-120 matrix metallopeptidase 9 Homo sapiens 134-139 19360311-10 2009 High basal MMP-9 levels responsive to PMA induction characterized the second group. Tetradecanoylphorbol Acetate 38-41 matrix metallopeptidase 9 Homo sapiens 11-16 18843292-10 2009 Coculture with PMA-treated THP-1 macrophages induced COX-2-dependent release of matrix metalloproteinase-9 and subsequent increased invasion of BCC cells. Tetradecanoylphorbol Acetate 15-18 matrix metallopeptidase 9 Homo sapiens 80-106 19208844-4 2009 The promoter assay showed that MMP-9 promoter activity was suppressed by RECK and that RECK-mediated suppression of MMP-9 promoter activity requires 12-O-tetradecanoylphorbol-13-acetate-responsive element (TRE) and kappaB sites. Tetradecanoylphorbol Acetate 149-185 matrix metallopeptidase 9 Homo sapiens 31-36 19208844-4 2009 The promoter assay showed that MMP-9 promoter activity was suppressed by RECK and that RECK-mediated suppression of MMP-9 promoter activity requires 12-O-tetradecanoylphorbol-13-acetate-responsive element (TRE) and kappaB sites. Tetradecanoylphorbol Acetate 149-185 matrix metallopeptidase 9 Homo sapiens 116-121 18835982-3 2009 Herein we demonstrate that vanillin reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 gelatinolytic activity and suppressed cell invasion through the down-regulation of MMP-9 gene transcription in HepG2 cells. Tetradecanoylphorbol Acetate 44-80 matrix metallopeptidase 9 Homo sapiens 95-100 18835982-3 2009 Herein we demonstrate that vanillin reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 gelatinolytic activity and suppressed cell invasion through the down-regulation of MMP-9 gene transcription in HepG2 cells. Tetradecanoylphorbol Acetate 44-80 matrix metallopeptidase 9 Homo sapiens 184-189 18835982-3 2009 Herein we demonstrate that vanillin reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 gelatinolytic activity and suppressed cell invasion through the down-regulation of MMP-9 gene transcription in HepG2 cells. Tetradecanoylphorbol Acetate 82-85 matrix metallopeptidase 9 Homo sapiens 95-100 18835982-3 2009 Herein we demonstrate that vanillin reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 gelatinolytic activity and suppressed cell invasion through the down-regulation of MMP-9 gene transcription in HepG2 cells. Tetradecanoylphorbol Acetate 82-85 matrix metallopeptidase 9 Homo sapiens 184-189 18835982-5 2009 Moreover, vanillin significantly suppressed the TPA-induced enzymatic activity of MMP-9 and decreased the induced mRNA level of MMP-9. Tetradecanoylphorbol Acetate 48-51 matrix metallopeptidase 9 Homo sapiens 82-87 18835982-5 2009 Moreover, vanillin significantly suppressed the TPA-induced enzymatic activity of MMP-9 and decreased the induced mRNA level of MMP-9. Tetradecanoylphorbol Acetate 48-51 matrix metallopeptidase 9 Homo sapiens 128-133 19418353-0 2009 Inhibitory effect of immature plum on PMA-induced MMP-9 expression in human hepatocellular carcinoma. Tetradecanoylphorbol Acetate 38-41 matrix metallopeptidase 9 Homo sapiens 50-55 18499341-2 2008 In this study, we found that CKS reduced 12-O-tetradecanoylphorbol-13-acetate (PMA)-enhanced Matrix metalloproteinases (MMP)-9 and MMP-2 activation in a dose-dependant manner and further inhibited HT-1080 cell invasion and migration. Tetradecanoylphorbol Acetate 41-77 matrix metallopeptidase 9 Homo sapiens 93-126 18499341-2 2008 In this study, we found that CKS reduced 12-O-tetradecanoylphorbol-13-acetate (PMA)-enhanced Matrix metalloproteinases (MMP)-9 and MMP-2 activation in a dose-dependant manner and further inhibited HT-1080 cell invasion and migration. Tetradecanoylphorbol Acetate 79-82 matrix metallopeptidase 9 Homo sapiens 93-126 18628248-2 2008 Increases in the protein, messenger RNA and enzyme activity levels of matrix metalloproteinase (MMP)-9 were observed in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells, and these were blocked by QUE, but not by quercitrin or rutin. Tetradecanoylphorbol Acetate 120-156 matrix metallopeptidase 9 Homo sapiens 70-102 18628248-2 2008 Increases in the protein, messenger RNA and enzyme activity levels of matrix metalloproteinase (MMP)-9 were observed in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated MCF-7 cells, and these were blocked by QUE, but not by quercitrin or rutin. Tetradecanoylphorbol Acetate 158-161 matrix metallopeptidase 9 Homo sapiens 70-102 18628248-3 2008 A translocation of protein kinase C (PKC)delta from the cytosol to the membrane followed by activation of extracellular signal-regulated kinase (ERK) and c-Jun/activator protein-1 (AP-1) by TPA was demonstrated, and TPA-induced MMP-9 activation and migration were inhibited by the pan PKC inhibitor, GF109203X, the specific PKCdelta inhibitor, rottlerin, an ERK inhibitor (PD98059) and an AP-1 inhibitor (curcumin). Tetradecanoylphorbol Acetate 190-193 matrix metallopeptidase 9 Homo sapiens 228-233 18628248-6 2008 Results suggested that OH groups at both C3" and C4" play central roles in QUE"s inhibition of TPA-induced MMP-9 activation and migration, and an additional OH at C3, C5 or C7 may increase the inhibitory potency of the 3",4"-diOH flavone against TPA-induced MMP-9 activity and migration. Tetradecanoylphorbol Acetate 95-98 matrix metallopeptidase 9 Homo sapiens 107-112 18628248-6 2008 Results suggested that OH groups at both C3" and C4" play central roles in QUE"s inhibition of TPA-induced MMP-9 activation and migration, and an additional OH at C3, C5 or C7 may increase the inhibitory potency of the 3",4"-diOH flavone against TPA-induced MMP-9 activity and migration. Tetradecanoylphorbol Acetate 95-98 matrix metallopeptidase 9 Homo sapiens 258-263 21479483-12 2008 Although phorbol 12-myristate 13-acetate treatment induced MMP-9 activity in E-type cells, it had no effect on R-type cells. Tetradecanoylphorbol Acetate 9-40 matrix metallopeptidase 9 Homo sapiens 59-64 18496150-7 2008 RESULTS: We discovered that the MMP-9 promoter was significantly stimulated by phorbol myristate acetate and TNF-alpha on luciferase reporter gene assays. Tetradecanoylphorbol Acetate 79-104 matrix metallopeptidase 9 Homo sapiens 32-37 18177935-4 2008 By using 12-O-tetradecanoylphorbol-13-acetate (TPA)-differentiated human promyelocytic HL-60 and promonocytic U-937 cells, we discover that polyamines block the expression, secretion and activation of MMP-9. Tetradecanoylphorbol Acetate 9-45 matrix metallopeptidase 9 Homo sapiens 201-206 18177935-4 2008 By using 12-O-tetradecanoylphorbol-13-acetate (TPA)-differentiated human promyelocytic HL-60 and promonocytic U-937 cells, we discover that polyamines block the expression, secretion and activation of MMP-9. Tetradecanoylphorbol Acetate 47-50 matrix metallopeptidase 9 Homo sapiens 201-206 18177935-7 2008 In addition, the NF-kappaB inhibitors (pyrrolidinedithiocarbamate, BAY-11-7082 and lactacystin) suppress the TPA-induced MMP-9 enzyme activity. Tetradecanoylphorbol Acetate 109-112 matrix metallopeptidase 9 Homo sapiens 121-126 18177935-10 2008 Therefore, we suggest that ODC inhibits the TNF-alpha-elevated MMP-9 activation via NF-kappaB as TPA-induced macrophage-like differentiation and this interrupting mechanism may provide a new conceivable resolution why leukemia is poorly differentiated besides atypical growth. Tetradecanoylphorbol Acetate 97-100 matrix metallopeptidase 9 Homo sapiens 63-68 18435488-3 2008 Our study delineates a unique brain endothelial phenotype in that MMP-9 secretion is increased upon phorbol 12-myristate 13-acetate (PMA) treatment of HBMEC. Tetradecanoylphorbol Acetate 100-131 matrix metallopeptidase 9 Homo sapiens 66-71 18435488-3 2008 Our study delineates a unique brain endothelial phenotype in that MMP-9 secretion is increased upon phorbol 12-myristate 13-acetate (PMA) treatment of HBMEC. Tetradecanoylphorbol Acetate 133-136 matrix metallopeptidase 9 Homo sapiens 66-71 18355442-4 2008 B428 inhibited basal and PMA-induced active MMP-9 in glioblastomas (GBM) U1242 cell media as well as cell invasion in vitro. Tetradecanoylphorbol Acetate 25-28 matrix metallopeptidase 9 Homo sapiens 44-49 18483307-2 2008 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-9 (MMP-9) enzyme activity and gene expression at both protein and mRNA levels were examined in human breast carcinoma cells (MCF-7 and MDA-MB-231), and the addition of the MMP-9 inhibitor, SB3CT, significantly suppressed TPA-induced invasion and migration according to the in vitro Transwell assay. Tetradecanoylphorbol Acetate 0-36 matrix metallopeptidase 9 Homo sapiens 51-77 18483307-2 2008 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-9 (MMP-9) enzyme activity and gene expression at both protein and mRNA levels were examined in human breast carcinoma cells (MCF-7 and MDA-MB-231), and the addition of the MMP-9 inhibitor, SB3CT, significantly suppressed TPA-induced invasion and migration according to the in vitro Transwell assay. Tetradecanoylphorbol Acetate 0-36 matrix metallopeptidase 9 Homo sapiens 79-84 18483307-2 2008 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-9 (MMP-9) enzyme activity and gene expression at both protein and mRNA levels were examined in human breast carcinoma cells (MCF-7 and MDA-MB-231), and the addition of the MMP-9 inhibitor, SB3CT, significantly suppressed TPA-induced invasion and migration according to the in vitro Transwell assay. Tetradecanoylphorbol Acetate 0-36 matrix metallopeptidase 9 Homo sapiens 248-253 18483307-2 2008 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-9 (MMP-9) enzyme activity and gene expression at both protein and mRNA levels were examined in human breast carcinoma cells (MCF-7 and MDA-MB-231), and the addition of the MMP-9 inhibitor, SB3CT, significantly suppressed TPA-induced invasion and migration according to the in vitro Transwell assay. Tetradecanoylphorbol Acetate 38-41 matrix metallopeptidase 9 Homo sapiens 51-77 18483307-2 2008 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-9 (MMP-9) enzyme activity and gene expression at both protein and mRNA levels were examined in human breast carcinoma cells (MCF-7 and MDA-MB-231), and the addition of the MMP-9 inhibitor, SB3CT, significantly suppressed TPA-induced invasion and migration according to the in vitro Transwell assay. Tetradecanoylphorbol Acetate 38-41 matrix metallopeptidase 9 Homo sapiens 79-84 18483307-2 2008 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-9 (MMP-9) enzyme activity and gene expression at both protein and mRNA levels were examined in human breast carcinoma cells (MCF-7 and MDA-MB-231), and the addition of the MMP-9 inhibitor, SB3CT, significantly suppressed TPA-induced invasion and migration according to the in vitro Transwell assay. Tetradecanoylphorbol Acetate 38-41 matrix metallopeptidase 9 Homo sapiens 248-253 18483307-4 2008 MCF-7 cells overexpressing HO-1 (MCF-7/HO-1) were established in the present study, and TPA-induced MMP-9 gene expression, tumor invasion, and colony formation were significantly reduced in MCF-7/HO-1 cells, compared with those in Neo-transfected cells. Tetradecanoylphorbol Acetate 88-91 matrix metallopeptidase 9 Homo sapiens 100-105 18483307-6 2008 Additionally, the addition of carbon monoxide, but not ferric ions, biliverdin, or bilirubin, inhibited TPA-induced invasion through suppressing MMP-9, extracellular signal-regulated kinases, and AP-1 activation stimulated by TPA. Tetradecanoylphorbol Acetate 104-107 matrix metallopeptidase 9 Homo sapiens 145-150 18088599-2 2008 In this study, we examined the inhibitory effect of capillarisin, a bioactive flavonoid of Artemisia capillaries, on phorbol myristate acetate (PMA)-induced MMP-9 expression in MCF-7 human breast carcinoma cells. Tetradecanoylphorbol Acetate 117-142 matrix metallopeptidase 9 Homo sapiens 157-162 18088599-2 2008 In this study, we examined the inhibitory effect of capillarisin, a bioactive flavonoid of Artemisia capillaries, on phorbol myristate acetate (PMA)-induced MMP-9 expression in MCF-7 human breast carcinoma cells. Tetradecanoylphorbol Acetate 144-147 matrix metallopeptidase 9 Homo sapiens 157-162 18088599-3 2008 Capillarisin significantly and selectively suppressed PMA-induced MMP-9 expression in MCF-7 and the Matrigel invasion assay showed that capillarisin reduces PMA-induced invasion of MCF-7 cells. Tetradecanoylphorbol Acetate 54-57 matrix metallopeptidase 9 Homo sapiens 66-71 18088599-4 2008 Capillarisin has been found to suppress PMA-induced MMP-9 expression through inhibition of the NF-kappaB-dependent transcriptional activity of MMP-9 gene via p38 MAPK and JNK signaling pathways. Tetradecanoylphorbol Acetate 40-43 matrix metallopeptidase 9 Homo sapiens 52-57 18088599-4 2008 Capillarisin has been found to suppress PMA-induced MMP-9 expression through inhibition of the NF-kappaB-dependent transcriptional activity of MMP-9 gene via p38 MAPK and JNK signaling pathways. Tetradecanoylphorbol Acetate 40-43 matrix metallopeptidase 9 Homo sapiens 143-148 18070596-4 2008 Further mechanistic studies revealed that irisolidone inhibits the binding of NF-kappaB and AP-1 to the MMP-9 promoter and suppresses the PMA-induced phosphorylation of ERK and JNK, which are upstream signaling molecules in MMP-9 expression. Tetradecanoylphorbol Acetate 138-141 matrix metallopeptidase 9 Homo sapiens 224-229 18024477-4 2008 The results showed that the LAB suppressed PMA-induced MMP-9 activity in a dose-dependent transcriptional level. Tetradecanoylphorbol Acetate 43-46 matrix metallopeptidase 9 Homo sapiens 55-60 18024477-9 2008 In conclusion, we demonstrated that the anti-invasive effects of the LAB on the PMA-induced HepG(2) cells might be through inhibiting the phosphorylation of ERK1/2 and reducing AP-1 and NF-kappaB DNA-binding activities, leading to downregulation of MMP-9 expression. Tetradecanoylphorbol Acetate 80-83 matrix metallopeptidase 9 Homo sapiens 249-254 18063832-6 2008 We aimed to determine the change in plasma F2IP levels over time and relationship with plasma MMP-9 in tPA-treated and tPA-untreated stroke patients. Tetradecanoylphorbol Acetate 103-106 matrix metallopeptidase 9 Homo sapiens 94-99 17761425-4 2007 MMP-9 effect was enhanced by phorbol 12-mysistrate-13-acetate (PMA), an alpha-secretase activator and inhibited by EDTA or SB-3CT, an MMP-9 inhibitor. Tetradecanoylphorbol Acetate 63-66 matrix metallopeptidase 9 Homo sapiens 0-5 17507007-4 2007 FPP-3 also suppressed TPA-induced increases in MMP-9 protein and mRNA levels, but did not alter TIMP-1 level. Tetradecanoylphorbol Acetate 22-25 matrix metallopeptidase 9 Homo sapiens 47-52 17114644-0 2007 Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. Tetradecanoylphorbol Acetate 24-27 matrix metallopeptidase 9 Homo sapiens 37-63 17114644-2 2007 Here, we found that an antitumor antibiotic, ascofuranone, inhibits invasion and MMP-9 induction induced by phorbol myristate acetate (PMA) in human cell lines. Tetradecanoylphorbol Acetate 108-133 matrix metallopeptidase 9 Homo sapiens 81-86 17114644-2 2007 Here, we found that an antitumor antibiotic, ascofuranone, inhibits invasion and MMP-9 induction induced by phorbol myristate acetate (PMA) in human cell lines. Tetradecanoylphorbol Acetate 135-138 matrix metallopeptidase 9 Homo sapiens 81-86 17214970-0 2007 Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells. Tetradecanoylphorbol Acetate 21-24 matrix metallopeptidase 9 Homo sapiens 33-38 17214970-2 2007 In this study, we examined the inhibitory effect of silibinin, a flavonoid antioxidant from milk thistle (Silybum marianum L.) on PMA-induced MMP-9 expression in MCF-7 human breast carcinoma cells. Tetradecanoylphorbol Acetate 130-133 matrix metallopeptidase 9 Homo sapiens 142-147 17214970-3 2007 Silibinin significantly and selectively suppressed PMA-induced MMP-9 expression in MCF-7. Tetradecanoylphorbol Acetate 51-54 matrix metallopeptidase 9 Homo sapiens 63-68 17214970-4 2007 Silibinin has been found to inhibit PMA-induced MMP-9 gene transcriptional activity by blocking the activation of AP-1 via MAPK signaling pathways. Tetradecanoylphorbol Acetate 36-39 matrix metallopeptidase 9 Homo sapiens 48-53 17214970-6 2007 These results suggest that silibinin represents a potential anti-metastatic agent suppressing PMA-induced cancer cell invasion through the specific inhibition of AP-1-dependent MMP-9 gene expression. Tetradecanoylphorbol Acetate 94-97 matrix metallopeptidase 9 Homo sapiens 177-182 17334233-0 2007 PMA-induced up-regulation of MMP-9 is regulated by a PKCalpha-NF-kappaB cascade in human lung epithelial cells. Tetradecanoylphorbol Acetate 0-3 matrix metallopeptidase 9 Homo sapiens 29-34 17334233-3 2007 In this study, we show that phorbol myristate acetate (PMA) induces MMP-9 expression via a protein kinase Calpha (PKCalpha)-dependent signaling cascade in BEAS-2B human lung epithelial cells. Tetradecanoylphorbol Acetate 28-53 matrix metallopeptidase 9 Homo sapiens 68-73 17334233-3 2007 In this study, we show that phorbol myristate acetate (PMA) induces MMP-9 expression via a protein kinase Calpha (PKCalpha)-dependent signaling cascade in BEAS-2B human lung epithelial cells. Tetradecanoylphorbol Acetate 55-58 matrix metallopeptidase 9 Homo sapiens 68-73 17334233-4 2007 Pretreatment with either GF109203X, a general PKC inhibitor, or Go6976, a PKCalpha/beta isozyme inhibitor, inhibited PMA-induced activation of the MMP-9 promoter, as did transient transfection with PKCalpha antisense oligonuclotides. Tetradecanoylphorbol Acetate 117-120 matrix metallopeptidase 9 Homo sapiens 147-152 17200207-3 2007 Gene clustering revealed a robust eightfold increase in matrix metalloproteinase (MMP)-9 expression in surgically resected human invasive PAs and in the (nonfunctioning) HP75 human pituitary tumor-derived cell line treated with phorbol-12-myristate-13-acetate; these results were confirmed by real-time polymerase chain reaction, gelatin zymography, reverse transcriptase-polymerase chain reaction, Western blot, immunohistochemistry, and Northern blot analyses. Tetradecanoylphorbol Acetate 228-259 matrix metallopeptidase 9 Homo sapiens 56-88 17200207-5 2007 In a transmembrane invasion assay, phorbol-12-myristate-13-acetate (100 nmol/L) increased the number of invaded HP75 cells, a process that was attenuated by PKC inhibitors, MMP-9 antibody, PKC-alpha siRNA, or PKC-delta siRNA. Tetradecanoylphorbol Acetate 35-66 matrix metallopeptidase 9 Homo sapiens 173-178 17404058-3 2007 Treatment of MCF10A cells with TPA induced the upregulation of COX-2 and MMP-9, and this was attenuated by jaceosidin treatment. Tetradecanoylphorbol Acetate 31-34 matrix metallopeptidase 9 Homo sapiens 73-78 17404058-6 2007 These results suggest that jaceosidin inhibits the TPA-induced upregulation of COX-2 and MMP-9 by blocking ERK-1 and -2 phosphorylation in human breast epithelial cells, which may be indicative of its chemopreventive potential. Tetradecanoylphorbol Acetate 51-54 matrix metallopeptidase 9 Homo sapiens 89-94 17848742-8 2007 Zymography demonstrated secretion of MMP-2 by untreated human testis cancer cells and MMP-9 with PMA induction. Tetradecanoylphorbol Acetate 97-100 matrix metallopeptidase 9 Homo sapiens 86-91 16953115-3 2006 Hsp70 overexpression in human monocytic cell line U937 was found to increase PMA-induced MMP-9 expression and enhance cell motility. Tetradecanoylphorbol Acetate 77-80 matrix metallopeptidase 9 Homo sapiens 89-94 16803512-5 2006 Untreated DoTc2 4510 cells showed MMP-9 expression, which was enhanced with phorbol 12-myristate 13-acetate treatment. Tetradecanoylphorbol Acetate 76-107 matrix metallopeptidase 9 Homo sapiens 34-39 17075289-7 2006 RESULTS: We detected the de novo synthesis of MMP-9 in HCMC after stimulation with PMA and found that the synthesis was mediated through protein kinase C-mitogen activated protein kinase kinase (MEK)-ERK pathway. Tetradecanoylphorbol Acetate 83-86 matrix metallopeptidase 9 Homo sapiens 46-51 17075289-8 2006 The MMP-9 production induced by PMA was suppressed by simultaneous treatment with A23187, whereas GM-CSF production was potentiated. Tetradecanoylphorbol Acetate 32-35 matrix metallopeptidase 9 Homo sapiens 4-9 16455237-4 2006 Conversely, PMA induced a marked increase of MT1-MMP and MMP-9. Tetradecanoylphorbol Acetate 12-15 matrix metallopeptidase 9 Homo sapiens 57-62 16380122-3 2006 sibirica, on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in MCF10A human breast epithelial cells. Tetradecanoylphorbol Acetate 77-113 matrix metallopeptidase 9 Homo sapiens 41-46 16380122-3 2006 sibirica, on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in MCF10A human breast epithelial cells. Tetradecanoylphorbol Acetate 115-118 matrix metallopeptidase 9 Homo sapiens 41-46 16380122-4 2006 Treatment of MCF10A cells with TPA led to the expression of COX-2 and MMP-9. Tetradecanoylphorbol Acetate 31-34 matrix metallopeptidase 9 Homo sapiens 70-75 16380122-7 2006 The upregulation of MMP-9 by TPA was also significantly reduced by hirsutenone. Tetradecanoylphorbol Acetate 29-32 matrix metallopeptidase 9 Homo sapiens 20-25 16380122-11 2006 Treatment of MCF10A cells with N-alpha-Tosyl-l-phenylalanine chloromethyl ketone, a specific inhibitor of NF-kappaB, reduced the TPA-induced expression of COX-2 and MMP-9. Tetradecanoylphorbol Acetate 129-132 matrix metallopeptidase 9 Homo sapiens 165-170 16380122-12 2006 In summary, hirsutenone inhibits the TPA-induced upregulation of COX-2 and MMP-9 in human breast epithelial cells, possibly by targeting NF-kappaB, which may contribute to its chemopreventive effects. Tetradecanoylphorbol Acetate 37-40 matrix metallopeptidase 9 Homo sapiens 75-80 15953625-5 2005 Our results demonstrate that extracts of broccoli and Rorripa suppressed TPA-induced MMP-9 activity and invasiveness in a concentration dependent manner as determined by zymographic analysis. Tetradecanoylphorbol Acetate 73-76 matrix metallopeptidase 9 Homo sapiens 85-90 16271356-6 2005 Exposure to PMA for 1-2 days additionally induced down-regulation of claudin-2 and up-regulation of barrier modulating matrix metalloproteinase (MMP)-9, respectively. Tetradecanoylphorbol Acetate 12-15 matrix metallopeptidase 9 Homo sapiens 119-151 16356124-2 2005 In the present study, we investigated the possible inhibitory effects of curcumin on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in MCF10A human breast epithelial (MCF10A) cells and the underlying mechanisms. Tetradecanoylphorbol Acetate 149-185 matrix metallopeptidase 9 Homo sapiens 113-118 16356124-2 2005 In the present study, we investigated the possible inhibitory effects of curcumin on the expression of COX-2 and MMP-9 induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in MCF10A human breast epithelial (MCF10A) cells and the underlying mechanisms. Tetradecanoylphorbol Acetate 187-190 matrix metallopeptidase 9 Homo sapiens 113-118 16356124-7 2005 Treatment of MCF10A cells with U0126, which is a pharmacological inhibitor of ERK1/2, reduced TPA-induced up-regulation of COX-2 and MMP-9. Tetradecanoylphorbol Acetate 94-97 matrix metallopeptidase 9 Homo sapiens 133-138 16356124-8 2005 Taken together, these findings suggest that curcumin inhibits the TPA-induced up-regulation of COX-2 and MMP-9 by suppressing ERK1/2 phosphorylation and NF-kappaB trans-activation in human breast epithelial cells, which may contribute to its chemopreventive potential. Tetradecanoylphorbol Acetate 66-69 matrix metallopeptidase 9 Homo sapiens 105-110 16323285-8 2005 Conversely, protein levels of manganese superoxide dismutase and the matrix metalloproteinases MMP-1 and MMP-9 were progressively increased in TPA-treated asPARP TUR cells, respectively. Tetradecanoylphorbol Acetate 143-146 matrix metallopeptidase 9 Homo sapiens 105-110 15863510-3 2005 Ascochlorin reduced the invasive activity of Caki-1 cells and inhibited phorbol 12-myristate 13-acetate-induced increases in MMP-9 expression and activity in a dose-dependent manner. Tetradecanoylphorbol Acetate 72-103 matrix metallopeptidase 9 Homo sapiens 125-130 15863510-7 2005 Moreover, transfection of Caki-1 cells with AP-1 decoy oligodeoxynucleotides resulted in the suppression of phorbol 12-myristate 13-acetate-induced MMP-9 expression and invasion. Tetradecanoylphorbol Acetate 108-139 matrix metallopeptidase 9 Homo sapiens 148-153 15728660-7 2005 Simvastatin reduced TPA- and PDGF/IL-1-induced MMP-9 secretion and mRNA levels, effects reversed by geranylgeranyl pyrophosphate and mimicked by inhibiting Rho geranylgeranylation or Rho-kinase (ROCK). Tetradecanoylphorbol Acetate 20-23 matrix metallopeptidase 9 Homo sapiens 47-52 15788229-0 2005 Tumor promoter TPA stimulates MMP-9 secretion from human keratinocytes by activation of superoxide-producing NADPH oxidase. Tetradecanoylphorbol Acetate 15-18 matrix metallopeptidase 9 Homo sapiens 30-35 15788229-2 2005 The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) increases MMP-9 secretion from normal human epidermal keratinocytes (NHEK) in vivo and in vitro. Tetradecanoylphorbol Acetate 19-55 matrix metallopeptidase 9 Homo sapiens 72-77 15788229-2 2005 The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) increases MMP-9 secretion from normal human epidermal keratinocytes (NHEK) in vivo and in vitro. Tetradecanoylphorbol Acetate 57-60 matrix metallopeptidase 9 Homo sapiens 72-77 15788229-3 2005 Here we show that the flavoprotein inhibitor diphenyleneiodinium (DPI) and the NADPH oxidase inhibitor apocynin block TPA-induced MMP-9 secretion of NHEK in vitro. Tetradecanoylphorbol Acetate 118-121 matrix metallopeptidase 9 Homo sapiens 130-135 15788229-4 2005 Furthermore, N-acetyl-L-cysteine and L-cysteine lowered TPA-induced MMP-9 secretion, suggesting an involvement of reactive oxygen species(ROS). Tetradecanoylphorbol Acetate 56-59 matrix metallopeptidase 9 Homo sapiens 68-73 15541021-4 2004 Addition of 12-O-tetradecanoyl-phorbol-13-acetate (10 ng/ml) to the culture medium caused an increase of production of MMP-2 and MMP-9 by cultured uveal melanocytes, and also stimulated the transcription of MMP-2 and MMP-9 of these cells. Tetradecanoylphorbol Acetate 12-49 matrix metallopeptidase 9 Homo sapiens 129-134 15541021-4 2004 Addition of 12-O-tetradecanoyl-phorbol-13-acetate (10 ng/ml) to the culture medium caused an increase of production of MMP-2 and MMP-9 by cultured uveal melanocytes, and also stimulated the transcription of MMP-2 and MMP-9 of these cells. Tetradecanoylphorbol Acetate 12-49 matrix metallopeptidase 9 Homo sapiens 217-222 15522912-6 2004 Treatment of HepG2 cells with CA (100 microg/mL) and CAPE (5 microg/mL) suppressed phorbol 12-myristate 13-acetate (PMA) -induced MMP-9 expression by inhibiting the function of NF-kappaB, but not AP-1. Tetradecanoylphorbol Acetate 83-114 matrix metallopeptidase 9 Homo sapiens 130-135 15522912-6 2004 Treatment of HepG2 cells with CA (100 microg/mL) and CAPE (5 microg/mL) suppressed phorbol 12-myristate 13-acetate (PMA) -induced MMP-9 expression by inhibiting the function of NF-kappaB, but not AP-1. Tetradecanoylphorbol Acetate 116-119 matrix metallopeptidase 9 Homo sapiens 130-135 15194008-4 2004 Zymographic analysis showed that emodin suppressed TPA-induced MMP-9 activity in a concentration-dependent manner. Tetradecanoylphorbol Acetate 51-54 matrix metallopeptidase 9 Homo sapiens 63-68 15481789-4 2004 Administration of 12-o-tetradecanoyl- phorbol-13-acetate (TPA) increased the release of MMP-9 but not of MMP-2. Tetradecanoylphorbol Acetate 18-56 matrix metallopeptidase 9 Homo sapiens 88-93 15481789-4 2004 Administration of 12-o-tetradecanoyl- phorbol-13-acetate (TPA) increased the release of MMP-9 but not of MMP-2. Tetradecanoylphorbol Acetate 58-61 matrix metallopeptidase 9 Homo sapiens 88-93 15481789-6 2004 Moreover, the increased level of MMP-9 by TPA in breast cancer was also higher than that in adjacent normal breast tissue and fibroadenoma. Tetradecanoylphorbol Acetate 42-45 matrix metallopeptidase 9 Homo sapiens 33-38 15287155-0 2004 Exogenous prostaglandin E2 inhibits TPA induced matrix metalloproteinase-9 production in MCF-7 cells. Tetradecanoylphorbol Acetate 36-39 matrix metallopeptidase 9 Homo sapiens 48-74 15287155-3 2004 TPA induced a strong production of MMP-9 while exogenous PGE2 had no effect on the basal MMP-9 level, but inhibited the TPA induced enzyme expression and matrigel invasiveness. Tetradecanoylphorbol Acetate 0-3 matrix metallopeptidase 9 Homo sapiens 35-40 14661062-3 2004 We found that resveratrol, a phytoalexin present in grapes, significantly inhibits the PMA-induced increase in MMP-9 expression and activity. Tetradecanoylphorbol Acetate 87-90 matrix metallopeptidase 9 Homo sapiens 111-116 15161022-3 2004 EGCG inhibited the phorbol 12-myristate 13-acetate (PMA)-induced cell invasiveness and MMP-9 expression in a dose-dependent manner. Tetradecanoylphorbol Acetate 19-50 matrix metallopeptidase 9 Homo sapiens 87-92 15161022-3 2004 EGCG inhibited the phorbol 12-myristate 13-acetate (PMA)-induced cell invasiveness and MMP-9 expression in a dose-dependent manner. Tetradecanoylphorbol Acetate 52-55 matrix metallopeptidase 9 Homo sapiens 87-92 15041541-0 2004 [Effects of mitogen-activated protein kinase on phorbol 12-myristate 13-acetate-induced matrix metalloproteinase-9 gene expression in cytotrophoblastic cells]. Tetradecanoylphorbol Acetate 48-79 matrix metallopeptidase 9 Homo sapiens 88-114 15041541-1 2004 OBJECTIVE: To explore the regulatory mechanism of matrix metalloproteinase-9 (MMP-9) gene expression induced by phorbol 12-myristate 13-acetate (PMA) in cytotrophoblastic cells. Tetradecanoylphorbol Acetate 112-143 matrix metallopeptidase 9 Homo sapiens 50-76 15041541-1 2004 OBJECTIVE: To explore the regulatory mechanism of matrix metalloproteinase-9 (MMP-9) gene expression induced by phorbol 12-myristate 13-acetate (PMA) in cytotrophoblastic cells. Tetradecanoylphorbol Acetate 112-143 matrix metallopeptidase 9 Homo sapiens 78-83 15041541-1 2004 OBJECTIVE: To explore the regulatory mechanism of matrix metalloproteinase-9 (MMP-9) gene expression induced by phorbol 12-myristate 13-acetate (PMA) in cytotrophoblastic cells. Tetradecanoylphorbol Acetate 145-148 matrix metallopeptidase 9 Homo sapiens 50-76 15041541-1 2004 OBJECTIVE: To explore the regulatory mechanism of matrix metalloproteinase-9 (MMP-9) gene expression induced by phorbol 12-myristate 13-acetate (PMA) in cytotrophoblastic cells. Tetradecanoylphorbol Acetate 145-148 matrix metallopeptidase 9 Homo sapiens 78-83 15041541-3 2004 RESULTS: Cytotrophoblastic cells treated with PMA showed markedly increased MMP-9 mRNA level. Tetradecanoylphorbol Acetate 46-49 matrix metallopeptidase 9 Homo sapiens 76-81 15009705-0 2004 Matrix metalloproteinase 9 expression is coordinately modulated by the KRE-M9 and 12-O-tetradecanoyl-phorbol-13-acetate responsive elements. Tetradecanoylphorbol Acetate 82-119 matrix metallopeptidase 9 Homo sapiens 0-26 15009705-2 2004 The KRE-M9 element, which is located between the 12-O-tetradecanoyl-phorbol-13-acetate responsive element (TRE) and the transcription initiation site in the MMP-9 promoter, is essential for MMP-9 transcription in the absence of the TRE. Tetradecanoylphorbol Acetate 49-86 matrix metallopeptidase 9 Homo sapiens 190-195 14627504-4 2003 RESULTS: MMP-9 activity in U937 cells increased significantly after exposed to PMA at 10 nmol/L for 24 h without FCS (P<0.01). Tetradecanoylphorbol Acetate 79-82 matrix metallopeptidase 9 Homo sapiens 9-14 14627504-6 2003 Western blot and RT-PCR experiments displayed that MMP-9 protein (P<0.01) and mRNA expression (P<0.01) increased significantly in PMA-treated U937 cells. Tetradecanoylphorbol Acetate 136-139 matrix metallopeptidase 9 Homo sapiens 51-56 14515793-7 2003 Gelatin zymography results showed that MMP-9 expression in U937 cells increased significantly after exposed to PMA at 1 x 10(-8) mol.L-1 (P < 0.001); MMP-9 expression induced with phorbol myristate acetate(PMA) was inhibited by dexamethasone at 1 x 10(-9), 1 x 10(-7) and 1 x 10(-5) mol.L-1, indomethacin at 1 x 10(-6) and 1 x 10(-5) mol.L-1 and resveratrol at 1 x 10(-6) and 1 x 10(-5) mol.L-1. Tetradecanoylphorbol Acetate 111-114 matrix metallopeptidase 9 Homo sapiens 39-44 14515793-7 2003 Gelatin zymography results showed that MMP-9 expression in U937 cells increased significantly after exposed to PMA at 1 x 10(-8) mol.L-1 (P < 0.001); MMP-9 expression induced with phorbol myristate acetate(PMA) was inhibited by dexamethasone at 1 x 10(-9), 1 x 10(-7) and 1 x 10(-5) mol.L-1, indomethacin at 1 x 10(-6) and 1 x 10(-5) mol.L-1 and resveratrol at 1 x 10(-6) and 1 x 10(-5) mol.L-1. Tetradecanoylphorbol Acetate 111-114 matrix metallopeptidase 9 Homo sapiens 153-158 14515793-7 2003 Gelatin zymography results showed that MMP-9 expression in U937 cells increased significantly after exposed to PMA at 1 x 10(-8) mol.L-1 (P < 0.001); MMP-9 expression induced with phorbol myristate acetate(PMA) was inhibited by dexamethasone at 1 x 10(-9), 1 x 10(-7) and 1 x 10(-5) mol.L-1, indomethacin at 1 x 10(-6) and 1 x 10(-5) mol.L-1 and resveratrol at 1 x 10(-6) and 1 x 10(-5) mol.L-1. Tetradecanoylphorbol Acetate 183-208 matrix metallopeptidase 9 Homo sapiens 39-44 14515793-7 2003 Gelatin zymography results showed that MMP-9 expression in U937 cells increased significantly after exposed to PMA at 1 x 10(-8) mol.L-1 (P < 0.001); MMP-9 expression induced with phorbol myristate acetate(PMA) was inhibited by dexamethasone at 1 x 10(-9), 1 x 10(-7) and 1 x 10(-5) mol.L-1, indomethacin at 1 x 10(-6) and 1 x 10(-5) mol.L-1 and resveratrol at 1 x 10(-6) and 1 x 10(-5) mol.L-1. Tetradecanoylphorbol Acetate 183-208 matrix metallopeptidase 9 Homo sapiens 153-158 14515793-7 2003 Gelatin zymography results showed that MMP-9 expression in U937 cells increased significantly after exposed to PMA at 1 x 10(-8) mol.L-1 (P < 0.001); MMP-9 expression induced with phorbol myristate acetate(PMA) was inhibited by dexamethasone at 1 x 10(-9), 1 x 10(-7) and 1 x 10(-5) mol.L-1, indomethacin at 1 x 10(-6) and 1 x 10(-5) mol.L-1 and resveratrol at 1 x 10(-6) and 1 x 10(-5) mol.L-1. Tetradecanoylphorbol Acetate 209-212 matrix metallopeptidase 9 Homo sapiens 39-44 14515793-7 2003 Gelatin zymography results showed that MMP-9 expression in U937 cells increased significantly after exposed to PMA at 1 x 10(-8) mol.L-1 (P < 0.001); MMP-9 expression induced with phorbol myristate acetate(PMA) was inhibited by dexamethasone at 1 x 10(-9), 1 x 10(-7) and 1 x 10(-5) mol.L-1, indomethacin at 1 x 10(-6) and 1 x 10(-5) mol.L-1 and resveratrol at 1 x 10(-6) and 1 x 10(-5) mol.L-1. Tetradecanoylphorbol Acetate 209-212 matrix metallopeptidase 9 Homo sapiens 153-158 12810681-0 2003 Dykellic acid inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting nuclear factor kappa B transcriptional activity. Tetradecanoylphorbol Acetate 23-48 matrix metallopeptidase 9 Homo sapiens 57-83 12810681-2 2003 Expression of MMPs is regulated by cytokines and signal transduction pathways, including those activated by phorbol myristate acetate. Tetradecanoylphorbol Acetate 108-133 matrix metallopeptidase 9 Homo sapiens 14-18 12810681-3 2003 We found that dykellic acid, a fungal metabolite, significantly inhibits the phorbol myristate acetate-induced increase in MMP-9 expression and activity. Tetradecanoylphorbol Acetate 77-102 matrix metallopeptidase 9 Homo sapiens 123-128 12745093-2 2003 We found that phorbol-12-myristate-13-acetate (PMA)-stimulated invasion of the hepatocellular carcinoma (HCC) SNU-387 and SNU-398 cells and that PMA induced the secretion of MMP-9 in the cells, but did not induce the secretion of MMP-2. Tetradecanoylphorbol Acetate 14-45 matrix metallopeptidase 9 Homo sapiens 174-179 12745093-2 2003 We found that phorbol-12-myristate-13-acetate (PMA)-stimulated invasion of the hepatocellular carcinoma (HCC) SNU-387 and SNU-398 cells and that PMA induced the secretion of MMP-9 in the cells, but did not induce the secretion of MMP-2. Tetradecanoylphorbol Acetate 47-50 matrix metallopeptidase 9 Homo sapiens 174-179 12788669-7 2003 Administration of TPA, Con-A, and RGD increased the expression of MMPs 1, 2, 9, and 10. Tetradecanoylphorbol Acetate 18-21 matrix metallopeptidase 9 Homo sapiens 66-70 12788669-9 2003 MAPK-I had no effect on constitutive MMP expression but reduced or abolished the TPA up-regulation of MMP-9 in MDA-MB-231 and MCF-7. Tetradecanoylphorbol Acetate 81-84 matrix metallopeptidase 9 Homo sapiens 102-107 12620479-7 2003 RESULT(S): Phorbol 12-myristate 13-acetate elicited an increase in MMP-9 and TIMP-1 secretion in both groups and apparently did not affect progesterone secretion. Tetradecanoylphorbol Acetate 11-42 matrix metallopeptidase 9 Homo sapiens 67-72 12606037-3 2003 These results support a role for ARF in PMA-stimulated MMP-9 secretion. Tetradecanoylphorbol Acetate 40-43 matrix metallopeptidase 9 Homo sapiens 55-60 12572591-9 2002 Substrate zymography confirmed increased release of MMP-9 in response to PMA (control vs. PMA 10(-8) and PMA 10(-7) mol/l; p < 0.01). Tetradecanoylphorbol Acetate 73-76 matrix metallopeptidase 9 Homo sapiens 52-57 12208511-2 2002 We found that in a dose-dependent manner soluble CD163 induces a decrease in CD69 expression, a reduced [(3)H]thymidine uptake and a down-regulated matrix metalloproteinase-9 RNA expression in phorbol myristate acetate-stimulated T-cells. Tetradecanoylphorbol Acetate 193-218 matrix metallopeptidase 9 Homo sapiens 148-174 12054499-3 2002 As shown by gelatin zymography, both FGF-2 and TPA stimulated the secretion of MMP-9 in MCF-7 cells while they did not change the level of MMP-2 secretion. Tetradecanoylphorbol Acetate 47-50 matrix metallopeptidase 9 Homo sapiens 79-84 12054499-5 2002 The FGF-2- and TPA-induced MMP-9 secretion was significantly inhibited by transient transfection of MCF-7 cells with dominant negative Ras (Ras-N17) and by treatment with MEK(1/2) inhibitor PD98059. Tetradecanoylphorbol Acetate 15-18 matrix metallopeptidase 9 Homo sapiens 27-32 12054499-6 2002 A pan-protein kinase C (PKC) inhibitor, GF109203X, was found to totally abolish the FGF-2- and TPA-induced MMP-9 secretion and ERK(1/2) phosphorylation. Tetradecanoylphorbol Acetate 95-98 matrix metallopeptidase 9 Homo sapiens 107-112 12054499-8 2002 These results demonstrated that FGF-2 and TPA induce MMP-9 secretion in MCF-7 cells mainly through PKC-dependent activation of the Ras/ERK(1/2) signaling pathway. Tetradecanoylphorbol Acetate 42-45 matrix metallopeptidase 9 Homo sapiens 53-58 12058964-7 2002 TPA induced MMP-9 activity in MCF-7 cells and increased its activity in MDA-MB-231 cells, however, MMP-2 activity was not detected. Tetradecanoylphorbol Acetate 0-3 matrix metallopeptidase 9 Homo sapiens 12-17 11716547-4 2001 We have previously demonstrated that the tumor promoter TPA can induce MMP-9 expression via a third signaling cascade, the p38 pathway. Tetradecanoylphorbol Acetate 56-59 matrix metallopeptidase 9 Homo sapiens 71-76 11716547-5 2001 Considering that TPA is a potent activator of AP-1, we hypothesized that this transcription factor might also be required for p38 pathway-dependent MMP-9 regulation. Tetradecanoylphorbol Acetate 17-20 matrix metallopeptidase 9 Homo sapiens 148-153