PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23614738-10 2013 TNFalpha, 12-O-Tetradecanoylphorbol 13-acetate (TPA) and UVB irradiation induced Ser727 phosphorylation of STAT3 in an ERK1/2- and p38 MAPK-dependent manner, which resulted in a modulatory effect on STAT3 transcriptional activity. Tetradecanoylphorbol Acetate 10-46 signal transducer and activator of transcription 3 Homo sapiens 107-112 23614738-10 2013 TNFalpha, 12-O-Tetradecanoylphorbol 13-acetate (TPA) and UVB irradiation induced Ser727 phosphorylation of STAT3 in an ERK1/2- and p38 MAPK-dependent manner, which resulted in a modulatory effect on STAT3 transcriptional activity. Tetradecanoylphorbol Acetate 10-46 signal transducer and activator of transcription 3 Homo sapiens 199-204 23614738-10 2013 TNFalpha, 12-O-Tetradecanoylphorbol 13-acetate (TPA) and UVB irradiation induced Ser727 phosphorylation of STAT3 in an ERK1/2- and p38 MAPK-dependent manner, which resulted in a modulatory effect on STAT3 transcriptional activity. Tetradecanoylphorbol Acetate 48-51 signal transducer and activator of transcription 3 Homo sapiens 107-112 23614738-10 2013 TNFalpha, 12-O-Tetradecanoylphorbol 13-acetate (TPA) and UVB irradiation induced Ser727 phosphorylation of STAT3 in an ERK1/2- and p38 MAPK-dependent manner, which resulted in a modulatory effect on STAT3 transcriptional activity. Tetradecanoylphorbol Acetate 48-51 signal transducer and activator of transcription 3 Homo sapiens 199-204 33717069-7 2021 Overexpression of LOC645166 in Jurkat cells down-regulated the IL-23p19 expression and suppressed the JAK2/STAT3 signaling in response to stimulation by phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate 153-184 signal transducer and activator of transcription 3 Homo sapiens 107-112 32289862-0 2020 Heparanase Facilitates PMA-Induced Megakaryocytic Differentiation in K562 Cells via Interleukin 6/STAT3 Pathway. Tetradecanoylphorbol Acetate 23-26 signal transducer and activator of transcription 3 Homo sapiens 98-103 31893611-0 2020 Methyl linderone suppresses TPA-stimulated IL-8 and MMP-9 expression via the ERK/STAT3 pathway in MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 28-31 signal transducer and activator of transcription 3 Homo sapiens 81-86 31893611-8 2020 Taken together, our findings indicated that ML attenuated the TPA-stimulated invasion and migration of MCF-7 cells by suppressing the phosphorylation of ERK and its downstream factors, AP-1 and STAT3. Tetradecanoylphorbol Acetate 62-65 signal transducer and activator of transcription 3 Homo sapiens 194-199 30616203-5 2019 As a possible link between STAT3, p53-p21 and KSHV lytic cycle, we found that TPA and AG490 reduced the expression of KAP-1, promoting p53 stability, p21 transcription and KSHV lytic cycle activation in PEL cells. Tetradecanoylphorbol Acetate 78-81 signal transducer and activator of transcription 3 Homo sapiens 27-32 30466990-0 2018 Orientin inhibits invasion by suppressing MMP-9 and IL-8 expression via the PKCalpha/ ERK/AP-1/STAT3-mediated signaling pathways in TPA-treated MCF-7 breast cancer cells. Tetradecanoylphorbol Acetate 132-135 signal transducer and activator of transcription 3 Homo sapiens 95-100 30466990-7 2018 TPA-induced membrane translocation of protein kinase C alpha (PKCalpha), phosphorylation of extracellular signal regulated kinase (ERK), and nuclear translocations of activator protein-1 (AP-1) and signal transducer and activator of transcription 3 (STAT3) were downregulated by orientin. Tetradecanoylphorbol Acetate 0-3 signal transducer and activator of transcription 3 Homo sapiens 198-248 30466990-7 2018 TPA-induced membrane translocation of protein kinase C alpha (PKCalpha), phosphorylation of extracellular signal regulated kinase (ERK), and nuclear translocations of activator protein-1 (AP-1) and signal transducer and activator of transcription 3 (STAT3) were downregulated by orientin. Tetradecanoylphorbol Acetate 0-3 signal transducer and activator of transcription 3 Homo sapiens 250-255 30466990-9 2018 CONCLUSION: Orientin inhibits migratory and invasive responses by suppressing MMP-9 and IL-8 expression through mitigation of TPA-induced PKCalpha and ERK activation, as well as the nuclear translocation of AP-1 and STAT3. Tetradecanoylphorbol Acetate 126-129 signal transducer and activator of transcription 3 Homo sapiens 216-221 30154906-6 2018 Furthermore, KJS018A diminished the effect of PMA, an inflammatory inducer via IL-6/STAT3/Cox-2 pathway. Tetradecanoylphorbol Acetate 46-49 signal transducer and activator of transcription 3 Homo sapiens 84-89 27036017-5 2016 WP1066, a STAT3 inhibitor, suppressed TPA-induced STAT3alpha DNA binding activity and beta-catenin expression. Tetradecanoylphorbol Acetate 38-41 signal transducer and activator of transcription 3 Homo sapiens 10-15 27036017-5 2016 WP1066, a STAT3 inhibitor, suppressed TPA-induced STAT3alpha DNA binding activity and beta-catenin expression. Tetradecanoylphorbol Acetate 38-41 signal transducer and activator of transcription 3 Homo sapiens 50-55 24496235-6 2014 EGF and 12-O-tetradecanoylphorbol-13-acetate induce Stat3 mitochondrial translocation mediated through the phosphorylation of Stat3 at Ser727. Tetradecanoylphorbol Acetate 8-44 signal transducer and activator of transcription 3 Homo sapiens 52-57 24496235-6 2014 EGF and 12-O-tetradecanoylphorbol-13-acetate induce Stat3 mitochondrial translocation mediated through the phosphorylation of Stat3 at Ser727. Tetradecanoylphorbol Acetate 8-44 signal transducer and activator of transcription 3 Homo sapiens 126-131 22927445-9 2012 PMA-induced enhancement of STAT3 phosphorylation was observed only in IL-32alpha-expressing cells, and this enhancement was inhibited by Ro-31-8220, but not by Go6976. Tetradecanoylphorbol Acetate 0-3 signal transducer and activator of transcription 3 Homo sapiens 27-32 22418867-5 2012 12-O-tetradecanoylphorbol-13-acetate-induced increase in cell survival activity and nuclear translocation of STAT3 was associated with Ser727 phosphorylation. Tetradecanoylphorbol Acetate 0-36 signal transducer and activator of transcription 3 Homo sapiens 109-114 22336225-4 2012 Other indicators of PMA-induced HEL cell differentiation, such as increased expression of CD41/CD61 and an increase in cell complexity/granularity, were inhibited by cicaprost in an IP receptor-dependent and STAT3-dependent manner. Tetradecanoylphorbol Acetate 20-23 signal transducer and activator of transcription 3 Homo sapiens 208-213 20953574-5 2011 Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1. Tetradecanoylphorbol Acetate 95-126 signal transducer and activator of transcription 3 Homo sapiens 302-352 20953574-5 2011 Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1. Tetradecanoylphorbol Acetate 95-126 signal transducer and activator of transcription 3 Homo sapiens 354-359 20953574-5 2011 Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1. Tetradecanoylphorbol Acetate 128-131 signal transducer and activator of transcription 3 Homo sapiens 302-352 20953574-5 2011 Herein we report that Rab7b, a late endosome/lysosome-localized myeloid small GTPase, promotes phorbol-12-myristate-13-acetate (PMA)-induced megakaryocytic differentiation by increasing nuclear factor kappaB (NF-kappaB)-dependent IL-6 production and subsequently enhancing the association of activated signal transducer and activator of transcription 3 (STAT3) with GATA-1. Tetradecanoylphorbol Acetate 128-131 signal transducer and activator of transcription 3 Homo sapiens 354-359 19755418-0 2009 12-O-tetradecanoylphorbol-13-acetate inhibits melanoma growth by inactivation of STAT3 through protein kinase C-activated tyrosine phosphatase(s). Tetradecanoylphorbol Acetate 0-36 signal transducer and activator of transcription 3 Homo sapiens 81-86 19755418-2 2009 In this study, the involvement of the signal transducer and activator of transcription 3 (STAT3) in the TPA-induced growth inhibition of melanoma cells was examined. Tetradecanoylphorbol Acetate 104-107 signal transducer and activator of transcription 3 Homo sapiens 38-88 19755418-2 2009 In this study, the involvement of the signal transducer and activator of transcription 3 (STAT3) in the TPA-induced growth inhibition of melanoma cells was examined. Tetradecanoylphorbol Acetate 104-107 signal transducer and activator of transcription 3 Homo sapiens 90-95 19755418-3 2009 The in vitro growth and DNA synthesis of five melanoma cell lines, whose STAT3 was activated (phosphorylated), was inhibited by TPA, whereas that of WM35 and WM39 cells, whose STAT3 activity was at negligible levels, was considerably slow and not affected by TPA. Tetradecanoylphorbol Acetate 128-131 signal transducer and activator of transcription 3 Homo sapiens 73-78 19755418-5 2009 Treatment of WM1205Lu cells with TPA decreased both the phosphorylated STAT3 and the DNA-binding activity of STAT3. Tetradecanoylphorbol Acetate 33-36 signal transducer and activator of transcription 3 Homo sapiens 71-76 19755418-5 2009 Treatment of WM1205Lu cells with TPA decreased both the phosphorylated STAT3 and the DNA-binding activity of STAT3. Tetradecanoylphorbol Acetate 33-36 signal transducer and activator of transcription 3 Homo sapiens 109-114 19755418-6 2009 Pretreatment of WM1205Lu cells with either a protein-tyrosine phosphatase inhibitor or a protein kinase C (PKC) inhibitor prevented the inhibitory effects of TPA on the level of phosphorylated STAT3. Tetradecanoylphorbol Acetate 158-161 signal transducer and activator of transcription 3 Homo sapiens 193-198 19755418-8 2009 Introduction of the dominant negative mutant of one of these PKC isoforms into WM1205Lu cells inhibited the TPA-induced dephosphorylation of STAT3. Tetradecanoylphorbol Acetate 108-111 signal transducer and activator of transcription 3 Homo sapiens 141-146 19755418-11 2009 Because TPA did not affect c-Src activity, we conclude that the growth inhibitory effect of TPA on melanoma cells is mediated through inactivation of STAT3 by a PKC-activated tyrosine phosphatase(s). Tetradecanoylphorbol Acetate 92-95 signal transducer and activator of transcription 3 Homo sapiens 150-155 12626585-3 2003 Pretreatment of macrophages with PMA or the proinflammatory mediators LPS and TNF-alpha blocks IL-6-induced STAT3 activation, whereas IL-10-induced activation of STAT3 remains largely unaffected. Tetradecanoylphorbol Acetate 33-36 signal transducer and activator of transcription 3 Homo sapiens 108-113 10764798-1 2000 Mitogen-activated protein (MAP) kinases stimulated by phorbol 13-myristate 12-acetate (PMA) have been shown to inhibit interleukin-6-induced activation of STAT3 (Sengupta, T. K., Talbot, E. S., Scherle, P. A., and Ivashkiv, L. B. Tetradecanoylphorbol Acetate 87-90 signal transducer and activator of transcription 3 Homo sapiens 155-160 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Tetradecanoylphorbol Acetate 218-249 signal transducer and activator of transcription 3 Homo sapiens 102-107 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Tetradecanoylphorbol Acetate 218-249 signal transducer and activator of transcription 3 Homo sapiens 281-286 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Tetradecanoylphorbol Acetate 251-254 signal transducer and activator of transcription 3 Homo sapiens 102-107 9736697-1 1998 Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced Stat3 activation. Tetradecanoylphorbol Acetate 251-254 signal transducer and activator of transcription 3 Homo sapiens 281-286 9736697-4 1998 Inhibition of Stat3 DNA-binding activity and tyrosine phosphorylation by PMA, ionomycin, and granulocyte/macrophage-colony-stimulating factor was reversed when activation of the extracellular signal-regulated kinase (ERK) group of MAPKs was blocked by using specific kinase inhibitors. Tetradecanoylphorbol Acetate 73-76 signal transducer and activator of transcription 3 Homo sapiens 14-19 8989665-5 1997 TPA-treated cells showed a decreased sensitivity to CNTF and a sevenfold decrease in levels of STAT3. Tetradecanoylphorbol Acetate 0-3 signal transducer and activator of transcription 3 Homo sapiens 95-100 8798409-1 1996 We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A). Tetradecanoylphorbol Acetate 51-82 signal transducer and activator of transcription 3 Homo sapiens 169-221 8798409-1 1996 We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A). Tetradecanoylphorbol Acetate 51-82 signal transducer and activator of transcription 3 Homo sapiens 223-228 8798409-1 1996 We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A). Tetradecanoylphorbol Acetate 84-87 signal transducer and activator of transcription 3 Homo sapiens 169-221 8798409-1 1996 We reported recently that angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) transiently inhibit interleukin 6 (IL-6)-stimulated tyrosine phosphorylation of signal transducers and activators of transcription 3 (Stat3) and subsequent formation of sis-inducing factor-A (SIF-A). Tetradecanoylphorbol Acetate 84-87 signal transducer and activator of transcription 3 Homo sapiens 223-228