PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27810232-0 2017 Potential role of IL-17-producing CD4/CD8 double negative alphabeta T cells in psoriatic skin inflammation in a TPA-induced STAT3C transgenic mouse model. Tetradecanoylphorbol Acetate 112-115 signal transducer and activator of transcription 3 Mus musculus 124-129 28322331-6 2017 Western blot analysis showed that both phosphorylated STAT3 and phosphorylated AKT expressions were significantly increased in epidermis of TC-PTP-deficient mice compared to control mice following TPA treatment. Tetradecanoylphorbol Acetate 197-200 signal transducer and activator of transcription 3 Mus musculus 54-59 25232490-2 2014 Mice lacking the pro-oncogenic transcription factor STAT3 were shown to be protected from both colitis-associated and epidermal cancers induced by the AOM/DSS and DMBA/TPA protocols, respectively. Tetradecanoylphorbol Acetate 168-171 signal transducer and activator of transcription 3 Mus musculus 52-57 26100520-4 2015 The combination of ursolic acid + resveratrol inhibited TPA-induced signaling pathways, including EGFR, STAT3, Src, Akt, Cox-2, Fas, NF-kappaB, p38 MAPK, c-Jun, and JNK1/2 while increasing levels of tumor suppressors, such as p21 and PDCD4, to a greater extent compared with the groups treated with the individual compounds. Tetradecanoylphorbol Acetate 56-59 signal transducer and activator of transcription 3 Mus musculus 104-109 19789299-8 2009 Using Western blotting and immunohistochemical staining with phosphospecific antibodies, we show that coadministration of ATRA suppressed the 12-O-tetradecanoylphorbol-13-acetate-induced phosphorylation of Stat3 in both models, but was only able to suppress tumor formation in the SENCAR mice. Tetradecanoylphorbol Acetate 142-178 signal transducer and activator of transcription 3 Mus musculus 206-211 24631338-5 2014 TTGE blocked the induction of iNOS and COX-2 through the regulation of NF-kappaB and STAT3, which could explain the reduced TPA-induced edema symptoms. Tetradecanoylphorbol Acetate 124-127 signal transducer and activator of transcription 3 Mus musculus 85-90 21480396-8 2012 Both UVR and TPA treatment stimulated PKCepsilon-Stat3 interaction, Stat3Ser727 phosphorylation and Stat3-regulated gene COX-2 expression. Tetradecanoylphorbol Acetate 13-16 signal transducer and activator of transcription 3 Mus musculus 49-54 21480396-8 2012 Both UVR and TPA treatment stimulated PKCepsilon-Stat3 interaction, Stat3Ser727 phosphorylation and Stat3-regulated gene COX-2 expression. Tetradecanoylphorbol Acetate 13-16 signal transducer and activator of transcription 3 Mus musculus 68-73 19738054-4 2009 Targeted disruption of Stat3 in bulge region KSCs at the time of initiation also dramatically reduced the number of skin tumors (by approximately 80%) produced following promotion with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Tetradecanoylphorbol Acetate 203-239 signal transducer and activator of transcription 3 Mus musculus 23-28 21480396-0 2012 Ultraviolet radiation and 12-O-tetradecanoylphorbol-13-acetate-induced interaction of mouse epidermal protein kinase Cepsilon with Stat3 involve integration with ERK1/2. Tetradecanoylphorbol Acetate 26-62 signal transducer and activator of transcription 3 Mus musculus 131-136 20469933-10 2010 MEK1/2, c-Jun, and STAT3 knockdown also reduced basal as well as PMA-induced Tspo mRNA levels in NIH-3T3 cells. Tetradecanoylphorbol Acetate 65-68 signal transducer and activator of transcription 3 Mus musculus 19-24 17583567-7 2007 PKCepsilon overexpression increases Stat3 activation after either TPA treatment or UVR exposure. Tetradecanoylphorbol Acetate 66-69 signal transducer and activator of transcription 3 Mus musculus 36-41 17962218-5 2007 In addition, 5-OH-HxMF can inhibit TPA-induced phosphorylation and nuclear translocation of the signal transducer and activator of transcription-3. Tetradecanoylphorbol Acetate 35-38 signal transducer and activator of transcription 3 Mus musculus 96-146 18820286-6 2008 DDMN inhibited TPA-induced phosphorylation and nuclear translocation of the signal transducer and activator of transcription 3. Tetradecanoylphorbol Acetate 15-18 signal transducer and activator of transcription 3 Mus musculus 76-126 17700521-3 2008 Keratinocytes from K5.Stat3C mice showed increased survival following exposure to 7,12-dimethylbenz[a]anthracene (DMBA) and enhanced proliferation following exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 169-205 signal transducer and activator of transcription 3 Mus musculus 22-28 17700521-3 2008 Keratinocytes from K5.Stat3C mice showed increased survival following exposure to 7,12-dimethylbenz[a]anthracene (DMBA) and enhanced proliferation following exposure to 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 207-210 signal transducer and activator of transcription 3 Mus musculus 22-28 17700521-4 2008 In two-stage chemical carcinogenesis experiments using DMBA as the tumor initiator and TPA as the promoter, K5.Stat3C mice developed skin tumors with a shorter latency and in much greater number compared to non-transgenic littermates. Tetradecanoylphorbol Acetate 87-90 signal transducer and activator of transcription 3 Mus musculus 111-117 15059889-2 2004 Stat1, Stat3, and Stat5 were activated in mouse epidermis after treatment with different classes of tumor promoters, including 12-O-tetradecanoylphorbol-13-acetate (TPA), okadaic acid, and chrysarobin. Tetradecanoylphorbol Acetate 127-163 signal transducer and activator of transcription 3 Mus musculus 7-12 15343391-3 2004 The epidermis of Stat3-deficient mice showed a significantly reduced proliferative response following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) because of a defect in G1-to-S-phase cell cycle progression. Tetradecanoylphorbol Acetate 136-172 signal transducer and activator of transcription 3 Mus musculus 17-22 15343391-3 2004 The epidermis of Stat3-deficient mice showed a significantly reduced proliferative response following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) because of a defect in G1-to-S-phase cell cycle progression. Tetradecanoylphorbol Acetate 174-177 signal transducer and activator of transcription 3 Mus musculus 17-22 15343391-5 2004 Notably, Stat3-deficient mice were completely resistant to skin tumor development when DMBA was used as the initiator and TPA as the promoter. Tetradecanoylphorbol Acetate 122-125 signal transducer and activator of transcription 3 Mus musculus 9-14 15059889-7 2004 Abrogation of EGFR function in mouse epidermis using an EGFR kinase inhibitor or by overexpressing a dominant negative form of EGFR led to a reduction in Stat3 activation in response to TPA treatment. Tetradecanoylphorbol Acetate 186-189 signal transducer and activator of transcription 3 Mus musculus 154-159 15059889-8 2004 Immunoprecipitation analyses using lysates from TPA-treated epidermis and skin papillomas showed enhanced interaction between the EGFR and Stat3. Tetradecanoylphorbol Acetate 48-51 signal transducer and activator of transcription 3 Mus musculus 139-144 15059889-9 2004 Finally, Stat3 deficiency in mouse epidermis significantly reduced the proliferative response after TPA treatment. Tetradecanoylphorbol Acetate 100-103 signal transducer and activator of transcription 3 Mus musculus 9-14 15059889-3 2004 In addition, Stat1, Stat3, and Stat5 were constitutively activated in skin tumors generated by the two-stage carcinogenesis regimen using 7,12-dimethylbenz(a)anthracene as initiator and TPA as promoter. Tetradecanoylphorbol Acetate 186-189 signal transducer and activator of transcription 3 Mus musculus 20-25 11087819-6 2000 It was demonstrated that anagen was successfully induced in Stat3-disrupted as well as wild-type mice by chemical or mechanical stimulation, i.e. , by topical application of phorbol 12-myristate 13-acetate (PMA) or by hair plucking, respectively. Tetradecanoylphorbol Acetate 174-205 signal transducer and activator of transcription 3 Mus musculus 60-65 11087819-6 2000 It was demonstrated that anagen was successfully induced in Stat3-disrupted as well as wild-type mice by chemical or mechanical stimulation, i.e. , by topical application of phorbol 12-myristate 13-acetate (PMA) or by hair plucking, respectively. Tetradecanoylphorbol Acetate 207-210 signal transducer and activator of transcription 3 Mus musculus 60-65