PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24946851-9 2014 A dose-dependent suppression in TPA-mediated TNF-alpha, IL-6, IFN-gamma, IL-17 and PGE2 levels which was associated with a decrease in infiltration of inflammatory cells was also observed with the treatment. Tetradecanoylphorbol Acetate 32-35 interleukin 17A Mus musculus 73-78 24322293-10 2014 Furthermore, intracellular cytokine staining revealed that expression of IL-4 and IL-17 were significantly enhanced in both the NK and NKT cells of infected mice after phorbol 12-myristate 13-acetate (PMA) and ionomycin stimulation (P < 0.05). Tetradecanoylphorbol Acetate 168-199 interleukin 17A Mus musculus 82-87 23989051-12 2014 Treatment with PMA and ionomycin significantly prevented the decrease in IL-17 but not IL-22 after EtOH exposure and burn injury. Tetradecanoylphorbol Acetate 15-18 interleukin 17A Mus musculus 73-78 24322293-10 2014 Furthermore, intracellular cytokine staining revealed that expression of IL-4 and IL-17 were significantly enhanced in both the NK and NKT cells of infected mice after phorbol 12-myristate 13-acetate (PMA) and ionomycin stimulation (P < 0.05). Tetradecanoylphorbol Acetate 201-204 interleukin 17A Mus musculus 82-87 23551262-5 2013 Expression and release of IL-17 was significantly higher in hepatic lymphocytes from infected mice compared with control mice in response to both non-specific stimulation with anti-CD3 monoclonal antibody plus/anti-CD28 monoclonal antibody and PMA plus ionomycin. Tetradecanoylphorbol Acetate 244-247 interleukin 17A Mus musculus 26-31 24212062-5 2013 FACS results indicated that Th17 cell was the main source of IL-17 in the infected pulmonary lymphocytes after phorbol-12-myristate-13-acetate (PMA) and Ionomycin stimulation. Tetradecanoylphorbol Acetate 111-142 interleukin 17A Mus musculus 61-66 24212062-5 2013 FACS results indicated that Th17 cell was the main source of IL-17 in the infected pulmonary lymphocytes after phorbol-12-myristate-13-acetate (PMA) and Ionomycin stimulation. Tetradecanoylphorbol Acetate 144-147 interleukin 17A Mus musculus 61-66 19229172-2 2008 In order to label IL-17-secreting cells, a single cell suspension of mouse splenocytes is prepared and stimulated at 37 degrees C with PMA/ionomycin to induce cytokine secretion. Tetradecanoylphorbol Acetate 135-138 interleukin 17A Mus musculus 18-23 23643258-4 2013 Moreover, IFN-gamma, IL-4, IL-9 and IL-17 secreted by gammadeltaT cells were detected by means of intracellular cytokine staining after stimulation with PMA plus ionomycin. Tetradecanoylphorbol Acetate 153-156 interleukin 17A Mus musculus 36-41 22289359-6 2012 Next, five azole-type fungicides, showing ROR inverse agonist activity, were tested on IL-17 mRNA expression in mouse T lymphoma EL4 cells treated with phorbol myristate acetate and ionomycin. Tetradecanoylphorbol Acetate 152-177 interleukin 17A Mus musculus 87-92 21346238-8 2011 Crossing IL-17A-deficient mice with K5.Stat3C mice resulted in partial attenuation of 12-O-tetradecanoylphorbol-13-acetate-induced lesions, which were further attenuated by anti-IL-12/23p40 Ab treatment. Tetradecanoylphorbol Acetate 86-122 interleukin 17A Mus musculus 9-15 19244111-8 2009 Remarkably, up-regulation of both IL-17 expression in the skin and T helper 17 (Th17) cell number in draining lymph nodes after DMBA/TPA treatment was dependent on IFNgamma signaling. Tetradecanoylphorbol Acetate 133-136 interleukin 17A Mus musculus 34-39 19244111-9 2009 Depletion of IL-17 not only decreased the DMBA/TPA-induced inflammation and keratinocyte proliferation but also delayed papilloma development. Tetradecanoylphorbol Acetate 47-50 interleukin 17A Mus musculus 13-18 27810232-0 2017 Potential role of IL-17-producing CD4/CD8 double negative alphabeta T cells in psoriatic skin inflammation in a TPA-induced STAT3C transgenic mouse model. Tetradecanoylphorbol Acetate 112-115 interleukin 17A Mus musculus 18-23 12054913-5 2002 IL-17 also enhanced the IL-6 synthesis stimulated by 12- O -tetradecanoylphorbol-13-acetate, a direct activator of protein kinase C. In addition, IL-17 amplified the IL-6 synthesis induced by ET-1. Tetradecanoylphorbol Acetate 53-91 interleukin 17A Mus musculus 0-5 12054913-5 2002 IL-17 also enhanced the IL-6 synthesis stimulated by 12- O -tetradecanoylphorbol-13-acetate, a direct activator of protein kinase C. In addition, IL-17 amplified the IL-6 synthesis induced by ET-1. Tetradecanoylphorbol Acetate 53-91 interleukin 17A Mus musculus 146-151 33788722-5 2021 The induction of IL-17 and other inflammatory cytokines by TPA was also suppressed by mPGES-1 deficiency, although DMBA-induced apoptosis was not affected. Tetradecanoylphorbol Acetate 59-62 interleukin 17A Mus musculus 17-22 34780714-5 2022 Although mRNA levels of inflammatory cytokines in skin after topical application of 12-O-tetradecanoylphorbol-13-acetate or imiquimod were comparable between kCYC+/- and wild-type mice, protein levels of inflammatory cytokines such as interleukin (IL)-17A, IL-22, and IL-23 were significantly upregulated in kCYC+/- mice in both models. Tetradecanoylphorbol Acetate 84-120 interleukin 17A Mus musculus 235-255 27810232-4 2017 OBJECTIVE: To investigate which subsets of IL-17-producing cells are involved in psoriasis-like skin inflammation in a TPA (tumor promoter 12-O-tetradecanoylphorbol-13-acetate)-induced K14.Stat3C mouse model. Tetradecanoylphorbol Acetate 119-122 interleukin 17A Mus musculus 43-48 27810232-4 2017 OBJECTIVE: To investigate which subsets of IL-17-producing cells are involved in psoriasis-like skin inflammation in a TPA (tumor promoter 12-O-tetradecanoylphorbol-13-acetate)-induced K14.Stat3C mouse model. Tetradecanoylphorbol Acetate 139-175 interleukin 17A Mus musculus 43-48 27810232-6 2017 RESULTS: We observed significantly increased numbers of IL-17-producing CD4+ T cells, CD8+ T cells and dermal gammadelta T cells in TPA-induced skin lesions of K14.Stat3C mice. Tetradecanoylphorbol Acetate 132-135 interleukin 17A Mus musculus 56-61 27810232-11 2017 CONCLUSION: In TPA-induced lesional skin of K14.Stat3C mice, IL-17-producing CD4+ Th17 cells, CD8+ Tc17 cells, dermal gammadelta T cells and TCR- cells probably containing ILCs all participated in skin inflammation, which is similar to human clinical psoriatic features. Tetradecanoylphorbol Acetate 15-18 interleukin 17A Mus musculus 61-66 25753147-5 2016 Notably, a short-term DMBA/TPA challenge, modeling the initial stages of chemical skin carcinogenesis treatment, elicited an enhanced inflammation in p38delta-null skin compared with skin of wild-type mice, as assessed by measuring the expression of pro-inflammatory cytokines, including IL-1beta, IL-6, IL-17, and TNFalpha. Tetradecanoylphorbol Acetate 27-30 interleukin 17A Mus musculus 304-309 27596969-7 2016 Interestingly, immunohistochemistry and flow cytometry analyses revealed that TPA treatment significantly increased infiltration of interleukin-17 (IL-17) producing dermal gammadelta T cells, while frequencies of gammadelta T cells was decreased by GF2 treatment, subsequently ameliorating inflammation in skin. Tetradecanoylphorbol Acetate 78-81 interleukin 17A Mus musculus 132-146 27596969-7 2016 Interestingly, immunohistochemistry and flow cytometry analyses revealed that TPA treatment significantly increased infiltration of interleukin-17 (IL-17) producing dermal gammadelta T cells, while frequencies of gammadelta T cells was decreased by GF2 treatment, subsequently ameliorating inflammation in skin. Tetradecanoylphorbol Acetate 78-81 interleukin 17A Mus musculus 148-153 27596969-8 2016 Concomitantly, TPA-mediated skin inflammation was significantly ameliorated in IL-17A knock out mice. Tetradecanoylphorbol Acetate 15-18 interleukin 17A Mus musculus 79-85 27596969-10 2016 These results clearly suggest that GF2 treatment ameliorates TPA-induced dermal inflammation by inhibiting production of IL-17 and ROS in gammadelta T cells and neutrophils, respectively. Tetradecanoylphorbol Acetate 61-64 interleukin 17A Mus musculus 121-126 26319521-5 2015 At the same time, the results showed that infected mouse splenic NK cells expressed increased levels of CD25 and CD69 and produced more IL-2, IL-4, and IL-17 and less IFN-gamma after stimulation with PMA and ionomycin. Tetradecanoylphorbol Acetate 200-203 interleukin 17A Mus musculus 152-157 26376757-11 2016 In vitro treatment of splenocytes isolated from healthy mice with rmMFG-E8 showed significant downregulation in PMA/ionomycin-induced IL-17 expression. Tetradecanoylphorbol Acetate 112-115 interleukin 17A Mus musculus 134-139 25682767-2 2015 It was suggested that the interleukin-23 (IL-23)/IL-17A cytokine axis played a critical role in the pathogenesis of 12-O-tetradecanoyl phorbol 12-myristate 13-acetate (TPA)-induced K14-VEGF transgenic psoriasis-like mice model. Tetradecanoylphorbol Acetate 168-171 interleukin 17A Mus musculus 49-55 25583575-5 2015 In addition, these isoflavones potently enhanced Il17a mRNA expression in mouse T lymphoma EL4 cells treated with phorbol myristate acetate and ionomycin, but showed slight enhancement of Il17a gene expression in RORalpha/gamma-knockdown EL4 cells. Tetradecanoylphorbol Acetate 114-139 interleukin 17A Mus musculus 49-54