PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15365312-6 2004 Shedding of p75 and p55 TNF receptors (Mono Mac 6 cells) or L-selectin (Jurkat T cells) was induced by stimulation with lipopolysaccharide and phorbol myristate acetate for Mono Mac 6 cells and PMA alone for Jurkat T cells. Tetradecanoylphorbol Acetate 143-168 selectin L Homo sapiens 60-70 15558242-2 2004 Treatment with chymotrypsin or phorbol 12-myristate 13-acetate to shedding of L: -selectin had no effect on subsequent kazinol B-induced Ca(2+) response. Tetradecanoylphorbol Acetate 31-62 selectin L Homo sapiens 78-90 16199204-3 2005 Albumin pretreatment significantly reduced CD11b expression and L-selectin shedding induced by fMLP and ROS production induced by PMA, G-CSF combined with PMA or LPS-fMLP, or anti-HNA-1a combined with PMA. Tetradecanoylphorbol Acetate 130-133 selectin L Homo sapiens 64-74 12949242-6 2003 Although inducible L-selectin shedding by phorbol 12-myristate 13-acetate stimulation was not observed by these cells in short-term assays, basal turnover did occur, resulting in the production of soluble L-selectin, as determined by enzyme-linked immunosorbent assay. Tetradecanoylphorbol Acetate 42-73 selectin L Homo sapiens 19-29 15178693-4 2004 L-selectin mutants defective for ERM binding show reduced localization to microvilli and decreased phorbol 12-myristate 13-acetate-induced shedding of the L-selectin ectodomain. Tetradecanoylphorbol Acetate 99-130 selectin L Homo sapiens 0-10 15178693-4 2004 L-selectin mutants defective for ERM binding show reduced localization to microvilli and decreased phorbol 12-myristate 13-acetate-induced shedding of the L-selectin ectodomain. Tetradecanoylphorbol Acetate 99-130 selectin L Homo sapiens 155-165 11706008-3 2002 Treatment of naive lymphocytes with phorbol myristate acetate (PMA) induces rapid ectodomain proteolytic down-regulation (shedding) of surface L-selectin via a protein kinase C (PKC)-dependent pathway. Tetradecanoylphorbol Acetate 36-61 selectin L Homo sapiens 143-153 12165498-2 2002 This study shows that CD62L acquired E-selectin-binding activity following phorbol ester (PMA) treatment of the Jurkat T cell line and anti-CD3/IL-2-driven proliferation of human T lymphocytes in vitro. Tetradecanoylphorbol Acetate 90-93 selectin L Homo sapiens 22-27 11706008-3 2002 Treatment of naive lymphocytes with phorbol myristate acetate (PMA) induces rapid ectodomain proteolytic down-regulation (shedding) of surface L-selectin via a protein kinase C (PKC)-dependent pathway. Tetradecanoylphorbol Acetate 63-66 selectin L Homo sapiens 143-153 11740186-5 2001 MATERIALS AND METHODS: A new technique was developed to detect cytokine expression in phorbol 12-myristate 13-acetate/ionomycin-activated CD62L and alpha4beta7-expressing CD4 T cell subsets, using the protease inhibitor KD-IX-73-4. Tetradecanoylphorbol Acetate 86-117 selectin L Homo sapiens 138-143 12749772-8 2000 An L-selectin cytoplasmic tail deletion mutant (344del.15) expressed in L1.2 pre-B cells was down-modulated by PMA or sulfatides, but not Dreg 200. Tetradecanoylphorbol Acetate 111-114 selectin L Homo sapiens 3-13 11156944-5 2001 Here, we demonstrate that PMA induces both reactive oxygen species (ROS) generation and TNF p75 receptor shedding in Mono Mac 6 cells, a human monocytic cell line, and l-selectin shedding in Jurkat T-cells. Tetradecanoylphorbol Acetate 26-29 selectin L Homo sapiens 168-178 10625005-4 2000 Ketamine inhibited both the N-formyl-methionyl-leucyl-phenylalanine- and phorbol 12-myristate 13-acetate-induced up-regulation of CD18 and shedding of CD62L, determined by flow cytometry, in a concentration-dependent manner. Tetradecanoylphorbol Acetate 73-104 selectin L Homo sapiens 151-156 10733103-4 2000 We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC. Tetradecanoylphorbol Acetate 119-150 selectin L Homo sapiens 165-175 10733103-4 2000 We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC. Tetradecanoylphorbol Acetate 152-155 selectin L Homo sapiens 165-175 7514078-5 1994 Stimulation with phorbol 12-myristate 13-acetate (PMA), however, gave rise to large, plastic adherent cells which also showed strong homotypic adhesion, expressed CD62L at minimal levels and CD11c at comparably highest levels and altogether mimicked the large cell variant of EF B cells. Tetradecanoylphorbol Acetate 17-48 selectin L Homo sapiens 163-168 9428734-3 1997 While cell surface L-selectin expression was abolished by phorbol 12-myristate 13-acetate (PMA), lymphocytes retained the ability to bind sulfatide in liquid phase as well as in immobilized solid phase. Tetradecanoylphorbol Acetate 58-89 selectin L Homo sapiens 19-29 9428734-3 1997 While cell surface L-selectin expression was abolished by phorbol 12-myristate 13-acetate (PMA), lymphocytes retained the ability to bind sulfatide in liquid phase as well as in immobilized solid phase. Tetradecanoylphorbol Acetate 91-94 selectin L Homo sapiens 19-29 8636132-6 1996 The hydroxamic acid-based peptide was also found to inhibit wild type L-selectin down-regulation from the surfaces of phorbol myristate acetate-activated peripheral blood lymphocytes and phytohemagglutinin-stimulated lymphoblasts. Tetradecanoylphorbol Acetate 118-143 selectin L Homo sapiens 70-80 9153259-2 1997 In this study, L-selectin was found to be phosphorylated in lymphoblastoid cell lines, and phosphorylation was enhanced by phorbol ester (phorbol 12-myristate 13-acetate (PMA)) treatment. Tetradecanoylphorbol Acetate 138-169 selectin L Homo sapiens 15-25 9153259-2 1997 In this study, L-selectin was found to be phosphorylated in lymphoblastoid cell lines, and phosphorylation was enhanced by phorbol ester (phorbol 12-myristate 13-acetate (PMA)) treatment. Tetradecanoylphorbol Acetate 171-174 selectin L Homo sapiens 15-25 9153259-6 1997 PMA-induced phosphorylation was on serine residues within the cytoplasmic tail of L-selectin that have been well conserved during recent evolution. Tetradecanoylphorbol Acetate 0-3 selectin L Homo sapiens 82-92 8693290-9 1996 While activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) induces rapid L-selectin down-regulation of L-selectin surface expression in both lymphocytes and granulocytes, the PKC inhibitor, H 7, was also found to down-regulate lymphocyte and granulocyte L-selectin surface expression. Tetradecanoylphorbol Acetate 46-77 selectin L Homo sapiens 98-108 8693290-9 1996 While activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) induces rapid L-selectin down-regulation of L-selectin surface expression in both lymphocytes and granulocytes, the PKC inhibitor, H 7, was also found to down-regulate lymphocyte and granulocyte L-selectin surface expression. Tetradecanoylphorbol Acetate 46-77 selectin L Homo sapiens 128-138 8693290-9 1996 While activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) induces rapid L-selectin down-regulation of L-selectin surface expression in both lymphocytes and granulocytes, the PKC inhibitor, H 7, was also found to down-regulate lymphocyte and granulocyte L-selectin surface expression. Tetradecanoylphorbol Acetate 46-77 selectin L Homo sapiens 128-138 8693290-9 1996 While activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) induces rapid L-selectin down-regulation of L-selectin surface expression in both lymphocytes and granulocytes, the PKC inhibitor, H 7, was also found to down-regulate lymphocyte and granulocyte L-selectin surface expression. Tetradecanoylphorbol Acetate 79-82 selectin L Homo sapiens 98-108 8693290-9 1996 While activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) induces rapid L-selectin down-regulation of L-selectin surface expression in both lymphocytes and granulocytes, the PKC inhibitor, H 7, was also found to down-regulate lymphocyte and granulocyte L-selectin surface expression. Tetradecanoylphorbol Acetate 79-82 selectin L Homo sapiens 128-138 8693290-9 1996 While activation of protein kinase C (PKC) by phorbol 12-myristate 13-acetate (PMA) induces rapid L-selectin down-regulation of L-selectin surface expression in both lymphocytes and granulocytes, the PKC inhibitor, H 7, was also found to down-regulate lymphocyte and granulocyte L-selectin surface expression. Tetradecanoylphorbol Acetate 79-82 selectin L Homo sapiens 128-138 7515343-8 1994 Thus, CD4+, Leu-8+ T cells from patients with PBC have a defect of proliferation and suppressor function that is reversed by coculture with PMA. Tetradecanoylphorbol Acetate 140-143 selectin L Homo sapiens 12-17 7508438-4 1994 Chymotrypsin and phorbol 12-myristate 13-acetate treatment of neutrophils caused shedding of L-selectin, but not of class I major histocompatibility complex antigens or beta 2 integrins, and blunted the capability of neutrophils to respond to sulfatides with an increase of cytosolic free calcium. Tetradecanoylphorbol Acetate 17-48 selectin L Homo sapiens 93-103 7514078-5 1994 Stimulation with phorbol 12-myristate 13-acetate (PMA), however, gave rise to large, plastic adherent cells which also showed strong homotypic adhesion, expressed CD62L at minimal levels and CD11c at comparably highest levels and altogether mimicked the large cell variant of EF B cells. Tetradecanoylphorbol Acetate 50-53 selectin L Homo sapiens 163-168 2044931-7 1991 Phorbol myristate acetate was found to be a strong inducer of Leu-8 messenger RNA in Leu-8-positive lymphocytes; however, phorbol myristate acetate did not induce membrane Leu-8 expression or Leu-8 messenger RNA in lamina propria lymphocytes. Tetradecanoylphorbol Acetate 0-25 selectin L Homo sapiens 62-67 7690438-9 1993 The functional importance of this aberrant glycosylation is unclear, however, since L-selectin is shed normally from phorbol myristate acetate (PMA)-stimulated CLL cells and since normal and CLL lymphocytes bind equally well in vitro to high endothelial venules. Tetradecanoylphorbol Acetate 144-147 selectin L Homo sapiens 84-94 2044931-7 1991 Phorbol myristate acetate was found to be a strong inducer of Leu-8 messenger RNA in Leu-8-positive lymphocytes; however, phorbol myristate acetate did not induce membrane Leu-8 expression or Leu-8 messenger RNA in lamina propria lymphocytes. Tetradecanoylphorbol Acetate 0-25 selectin L Homo sapiens 85-90 2044931-7 1991 Phorbol myristate acetate was found to be a strong inducer of Leu-8 messenger RNA in Leu-8-positive lymphocytes; however, phorbol myristate acetate did not induce membrane Leu-8 expression or Leu-8 messenger RNA in lamina propria lymphocytes. Tetradecanoylphorbol Acetate 0-25 selectin L Homo sapiens 85-90 2044931-7 1991 Phorbol myristate acetate was found to be a strong inducer of Leu-8 messenger RNA in Leu-8-positive lymphocytes; however, phorbol myristate acetate did not induce membrane Leu-8 expression or Leu-8 messenger RNA in lamina propria lymphocytes. Tetradecanoylphorbol Acetate 0-25 selectin L Homo sapiens 85-90 1709244-6 1991 As with normal lymphocytes, cells transfected with the LAM-1 cDNA and chronic lymphocytic leukemia (CLL) cells also shed LAM-1 following phorbol myristate acetate (PMA) exposure. Tetradecanoylphorbol Acetate 137-162 selectin L Homo sapiens 55-60 1709244-6 1991 As with normal lymphocytes, cells transfected with the LAM-1 cDNA and chronic lymphocytic leukemia (CLL) cells also shed LAM-1 following phorbol myristate acetate (PMA) exposure. Tetradecanoylphorbol Acetate 137-162 selectin L Homo sapiens 121-126 1709244-6 1991 As with normal lymphocytes, cells transfected with the LAM-1 cDNA and chronic lymphocytic leukemia (CLL) cells also shed LAM-1 following phorbol myristate acetate (PMA) exposure. Tetradecanoylphorbol Acetate 164-167 selectin L Homo sapiens 55-60 1709244-6 1991 As with normal lymphocytes, cells transfected with the LAM-1 cDNA and chronic lymphocytic leukemia (CLL) cells also shed LAM-1 following phorbol myristate acetate (PMA) exposure. Tetradecanoylphorbol Acetate 164-167 selectin L Homo sapiens 121-126 1701670-2 1990 Most circulating human neutrophils express the Leu-8 molecule, and activation of neutrophils with phorbol myristate acetate causes a rapid decline in Leu-8 membrane fluorescence staining within 15 minutes. Tetradecanoylphorbol Acetate 98-123 selectin L Homo sapiens 47-52 1701670-2 1990 Most circulating human neutrophils express the Leu-8 molecule, and activation of neutrophils with phorbol myristate acetate causes a rapid decline in Leu-8 membrane fluorescence staining within 15 minutes. Tetradecanoylphorbol Acetate 98-123 selectin L Homo sapiens 150-155 28235798-4 2017 Incubation of the L-selectin tail with cell extracts from phorbol 12-myristate 13-acetate-stimulated Raw 264.7 macrophages resulted in the binding of mu1A of the clathrin-coated vesicle AP-1 complex. Tetradecanoylphorbol Acetate 58-89 selectin L Homo sapiens 18-28 1702752-4 1990 Exposure of freshly isolated peripheral blood lymphocytes to phorbol 12-myristate 13-acetate (PMA) and/or calcium ionophores was found to cause rapid down-regulation of the Leu-8 antigen, with little or no Leu-8 reactivity remaining 1 hr after simultaneous addition of PMA and calcium ionophores to the culture medium. Tetradecanoylphorbol Acetate 61-92 selectin L Homo sapiens 173-178 1702752-4 1990 Exposure of freshly isolated peripheral blood lymphocytes to phorbol 12-myristate 13-acetate (PMA) and/or calcium ionophores was found to cause rapid down-regulation of the Leu-8 antigen, with little or no Leu-8 reactivity remaining 1 hr after simultaneous addition of PMA and calcium ionophores to the culture medium. Tetradecanoylphorbol Acetate 94-97 selectin L Homo sapiens 173-178 1702752-4 1990 Exposure of freshly isolated peripheral blood lymphocytes to phorbol 12-myristate 13-acetate (PMA) and/or calcium ionophores was found to cause rapid down-regulation of the Leu-8 antigen, with little or no Leu-8 reactivity remaining 1 hr after simultaneous addition of PMA and calcium ionophores to the culture medium. Tetradecanoylphorbol Acetate 94-97 selectin L Homo sapiens 206-211 1702752-9 1990 After Leu-8 down-regulation induced by 1 hr treatment with PMA or calcium ionophores. Tetradecanoylphorbol Acetate 59-62 selectin L Homo sapiens 6-11 20331435-4 2010 By using PMA and the phosphatase inhibitors cantharidin and calyculin A, we could selectively activate PKC or p38 MAPK respectively to promote TACE-dependent shedding of L-selectin. Tetradecanoylphorbol Acetate 9-12 selectin L Homo sapiens 170-180 24337742-5 2014 ADAM17 was found to be expressed on NK cells, and stimulation with PMA or N-ethyl-maleimide resulted in the shedding of FcgammaRIIIA/CD16A and CD62L, a specific substrate of ADAM17. Tetradecanoylphorbol Acetate 67-70 selectin L Homo sapiens 143-148 21131700-6 2010 In contrast to the differential effect of GM-CSF on neutrophils versus eosinophils, stimulation with phorbol myristate acetate demonstrated a similar degree of inhibition of rolling and L-selectin shedding by neutrophils and eosinophils suggesting that there was no defect in L-selectin shedding in the eosinophil donors who did not respond to GM-CSF. Tetradecanoylphorbol Acetate 101-126 selectin L Homo sapiens 186-196 21131700-6 2010 In contrast to the differential effect of GM-CSF on neutrophils versus eosinophils, stimulation with phorbol myristate acetate demonstrated a similar degree of inhibition of rolling and L-selectin shedding by neutrophils and eosinophils suggesting that there was no defect in L-selectin shedding in the eosinophil donors who did not respond to GM-CSF. Tetradecanoylphorbol Acetate 101-126 selectin L Homo sapiens 276-286