PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11023549-10 2000 These results suggested that tyrosinase-dependent oxidative metabolism of PA was at least partially involved in the enhanced effects of PA on TPA-induced inflammatory responses and thus tumor promotion. Tetradecanoylphorbol Acetate 142-145 tyrosinase Mus musculus 29-39 9582014-0 1998 In B16 melanoma cells, the inhibition of melanogenesis by TPA results from PKC activation and diminution of microphthalmia binding to the M-box of the tyrosinase promoter. Tetradecanoylphorbol Acetate 58-61 tyrosinase Mus musculus 151-161 9582014-4 1998 Further, the inhibition of melanogenesis by TPA results from a decrease of the tyrosinase promoter transcriptional activity and this effect is mimicked by over-expression of a constitutively active form of PKC alpha. Tetradecanoylphorbol Acetate 44-47 tyrosinase Mus musculus 79-89 9582014-6 1998 Additional experiments were undertaken to elucidate the mechanism by which TPA inhibits the tyrosinase gene transcription. Tetradecanoylphorbol Acetate 75-78 tyrosinase Mus musculus 92-102 9582014-7 1998 Deletions and mutation in the tyrosinase promoter showed that TPA acts on a M-box which is involved in tissue-specific expression and regulation by cAMP of the tyrosinase gene. Tetradecanoylphorbol Acetate 62-65 tyrosinase Mus musculus 30-40 9582014-7 1998 Deletions and mutation in the tyrosinase promoter showed that TPA acts on a M-box which is involved in tissue-specific expression and regulation by cAMP of the tyrosinase gene. Tetradecanoylphorbol Acetate 62-65 tyrosinase Mus musculus 160-170 9582014-9 1998 Since microphthalmia, strongly stimulates the transcriptional activity of the promoter we propose that TPA, through PKC activation, decreases microphthalmia binding to the M-box of the tyrosinase promoter, thereby leading to a reduced tyrosinase expression and melanogenesis inhibition. Tetradecanoylphorbol Acetate 103-106 tyrosinase Mus musculus 185-195 9582014-9 1998 Since microphthalmia, strongly stimulates the transcriptional activity of the promoter we propose that TPA, through PKC activation, decreases microphthalmia binding to the M-box of the tyrosinase promoter, thereby leading to a reduced tyrosinase expression and melanogenesis inhibition. Tetradecanoylphorbol Acetate 103-106 tyrosinase Mus musculus 235-245 7775602-4 1995 12-O-Tetradecanoylphorbol-13-acetate (TPA) or linoleic acid decreased tyrosinase activity, while dibutyryl cyclic adenosine monophosphate (dbcAMP) or palmitic acid increased it. Tetradecanoylphorbol Acetate 0-36 tyrosinase Mus musculus 70-80 7775602-4 1995 12-O-Tetradecanoylphorbol-13-acetate (TPA) or linoleic acid decreased tyrosinase activity, while dibutyryl cyclic adenosine monophosphate (dbcAMP) or palmitic acid increased it. Tetradecanoylphorbol Acetate 38-41 tyrosinase Mus musculus 70-80 7775602-6 1995 The number of melanosomes changed when agents which modulate the tyrosinase gene expression were added, since TPA decreased, dbcAMP increased, and linoleic acid or palmitic acid did not alter their number. Tetradecanoylphorbol Acetate 110-113 tyrosinase Mus musculus 65-75 7686498-6 1993 In contrast, 12-O-tetradecanoylphorbol 13-acetate reduced tyrosinase activity and eumelanin synthesis. Tetradecanoylphorbol Acetate 13-49 tyrosinase Mus musculus 58-68 1823929-6 1991 A tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA) decreased tyrosinase mRNA level at 30 nM concentration. Tetradecanoylphorbol Acetate 18-55 tyrosinase Mus musculus 72-82 1823929-6 1991 A tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA) decreased tyrosinase mRNA level at 30 nM concentration. Tetradecanoylphorbol Acetate 57-60 tyrosinase Mus musculus 72-82 1823929-7 1991 Dexamethasone antagonized this TPA-mediated decrease in tyrosinase mRNA. Tetradecanoylphorbol Acetate 31-34 tyrosinase Mus musculus 56-66 1704321-2 1990 In this study the effect of the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA), on the hormonal induction of tyrosinase was examined. Tetradecanoylphorbol Acetate 48-84 tyrosinase Mus musculus 121-131 1704321-2 1990 In this study the effect of the tumor promoter, 12-O-tetradecanoylphorbol 13-acetate (TPA), on the hormonal induction of tyrosinase was examined. Tetradecanoylphorbol Acetate 86-89 tyrosinase Mus musculus 121-131 1704321-3 1990 TPA was found to lower basal levels of tyrosinase activity in melanoma cells and to reduce tyrosinase levels in cells treated with either MSH (10(-7) M), dibutyryl cAMP (10(-4) M), isobutylmethylxanthine (IBMX, 10(-4) M), or with the potent MSH analogue, [Nle4,D-phe7]-alpha-MSH. Tetradecanoylphorbol Acetate 0-3 tyrosinase Mus musculus 39-49 1704321-3 1990 TPA was found to lower basal levels of tyrosinase activity in melanoma cells and to reduce tyrosinase levels in cells treated with either MSH (10(-7) M), dibutyryl cAMP (10(-4) M), isobutylmethylxanthine (IBMX, 10(-4) M), or with the potent MSH analogue, [Nle4,D-phe7]-alpha-MSH. Tetradecanoylphorbol Acetate 0-3 tyrosinase Mus musculus 91-101 1704321-5 1990 In order to determine how TPA may reduce tyrosinase activity in melanoma cells, the levels of tyrosinase mRNA in untreated or TPA-treated cells were determined by Northern blot analysis. Tetradecanoylphorbol Acetate 26-29 tyrosinase Mus musculus 41-51 1704321-5 1990 In order to determine how TPA may reduce tyrosinase activity in melanoma cells, the levels of tyrosinase mRNA in untreated or TPA-treated cells were determined by Northern blot analysis. Tetradecanoylphorbol Acetate 126-129 tyrosinase Mus musculus 94-104 1704321-7 1990 Tyrosinase mRNA levels in cultures exposed to TPA for 48 h were only 7% of control levels. Tetradecanoylphorbol Acetate 46-49 tyrosinase Mus musculus 0-10 1704321-8 1990 Tyrosinase mRNA levels in cells treated with both MSH and TPA were also lower than in cells treated with MSH alone. Tetradecanoylphorbol Acetate 58-61 tyrosinase Mus musculus 0-10 7620342-1 1995 Sequence analysis of the promoter region of the murine tyrosinase gene identified various consensus motifs including AP2 sites, cAMP and TPA response elements (CREs/TREs) and retinoic acid response element (RARE) half-sites. Tetradecanoylphorbol Acetate 137-140 tyrosinase Mus musculus 55-65 15067002-11 2004 Taken together, the present results indicate that the TPA-induced down-regulation of melanogenesis is mediated by PLD2 but not by PLD1 through the ubiquitin proteasome-mediated degradation of tyrosinase. Tetradecanoylphorbol Acetate 54-57 tyrosinase Mus musculus 192-202 12519122-6 2003 Using northern blots, we show that in DMEL-2 cells, TPA significantly increases the messenger ribonucleic acid (mRNA) levels of the tyrosinase gene family (tyrosinase, Tyrp1 and Dct) and the expression of Mitf. Tetradecanoylphorbol Acetate 52-55 tyrosinase Mus musculus 132-142 12519122-6 2003 Using northern blots, we show that in DMEL-2 cells, TPA significantly increases the messenger ribonucleic acid (mRNA) levels of the tyrosinase gene family (tyrosinase, Tyrp1 and Dct) and the expression of Mitf. Tetradecanoylphorbol Acetate 52-55 tyrosinase Mus musculus 156-166