PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1834742-9 1991 Furthermore, Jurkat cells grown continuously in 100 nM TPA regained full proliferative capacity after several weeks in culture and transferrin receptor expression returned to near the level seen in untreated Jurkat cells. Tetradecanoylphorbol Acetate 55-58 transferrin Homo sapiens 131-142 2401848-8 1990 Exposure of cells to phorbol myristate acetate resulted in a decrease in cell surface transferrin receptor and a decrease in the release of soluble transferrin receptor. Tetradecanoylphorbol Acetate 21-46 transferrin Homo sapiens 86-97 1846518-3 1991 In contrast, incubation of phorbol myristate acetate (PMA)-stimulated PMNs with holosaturated transferrin at pH 7.4 enhanced the release of Fe2+ from transferrin eightfold in association with marked generation of O2-. Tetradecanoylphorbol Acetate 27-52 transferrin Homo sapiens 94-105 1846518-3 1991 In contrast, incubation of phorbol myristate acetate (PMA)-stimulated PMNs with holosaturated transferrin at pH 7.4 enhanced the release of Fe2+ from transferrin eightfold in association with marked generation of O2-. Tetradecanoylphorbol Acetate 27-52 transferrin Homo sapiens 150-161 1846518-3 1991 In contrast, incubation of phorbol myristate acetate (PMA)-stimulated PMNs with holosaturated transferrin at pH 7.4 enhanced the release of Fe2+ from transferrin eightfold in association with marked generation of O2-. Tetradecanoylphorbol Acetate 54-57 transferrin Homo sapiens 94-105 1846518-3 1991 In contrast, incubation of phorbol myristate acetate (PMA)-stimulated PMNs with holosaturated transferrin at pH 7.4 enhanced the release of Fe2+ from transferrin eightfold in association with marked generation of O2-. Tetradecanoylphorbol Acetate 54-57 transferrin Homo sapiens 150-161 2224856-6 1990 We conclude that TPA-induced down-regulation of transferrin binding and internalization does not mediate the subsequent growth arrest and differentiation of HL-60 cells. Tetradecanoylphorbol Acetate 17-20 transferrin Homo sapiens 48-59 2401848-8 1990 Exposure of cells to phorbol myristate acetate resulted in a decrease in cell surface transferrin receptor and a decrease in the release of soluble transferrin receptor. Tetradecanoylphorbol Acetate 21-46 transferrin Homo sapiens 148-159 2196473-6 1990 Major induced alterations included down-regulation of CD4 (induced by TPA, and to a lesser extent by IFN-alpha), TPA-induced decrease of cell surface expression of transferrin receptor (unmodified by IFN-alpha) and IFN-alpha induced increase of antigen density (fluorescence intensity) of MHC class I antigen. Tetradecanoylphorbol Acetate 113-116 transferrin Homo sapiens 164-175 2702640-5 1989 However, a reduction in levels of receptor message appears to contribute to the maintenance of diminished transferrin receptor activity in these 12-O-tetradecanoylphorbol-13-acetate-treated cells. Tetradecanoylphorbol Acetate 145-181 transferrin Homo sapiens 106-117 3017998-5 1986 In contrast, activation of protein kinase C by phorbol myristate acetate markedly stimulated the internalization of both occupied and unoccupied transferrin receptors, even in cells with very low [Ca2+]i. Tetradecanoylphorbol Acetate 47-72 transferrin Homo sapiens 145-156 3624319-1 1987 We compared transferrin receptor (TfR) expression on human peripheral blood lymphocytes (PBL) activated by phorbol myristate acetate (PMA) or L-phytohemagglutinin (LPHA) using two techniques: (1) 125I-iron-saturated transferrin (FeTf) binding, (2) reactivity with monoclonal anti-TfR antibodies--OKT9 and B3/25. Tetradecanoylphorbol Acetate 107-132 transferrin Homo sapiens 12-23 3624319-1 1987 We compared transferrin receptor (TfR) expression on human peripheral blood lymphocytes (PBL) activated by phorbol myristate acetate (PMA) or L-phytohemagglutinin (LPHA) using two techniques: (1) 125I-iron-saturated transferrin (FeTf) binding, (2) reactivity with monoclonal anti-TfR antibodies--OKT9 and B3/25. Tetradecanoylphorbol Acetate 134-137 transferrin Homo sapiens 12-23 2844758-1 1988 The effects of the tumor promotor, 4 beta-phorbol 12 beta-myristate 13 alpha-acetate (PMA), on the intra- and extracellular distribution of transferrin receptors and rates of iron uptake were studied in normal developing myogenic cells and myogenic cells transformed with a temperature-sensitive strain of the Rous sarcoma virus. Tetradecanoylphorbol Acetate 86-89 transferrin Homo sapiens 140-151 3495445-6 1987 Activation markers such as the transferrin and interleukin 2 (IL2) receptors were markedly increased after 24 h incubation with TPA and ionomycin. Tetradecanoylphorbol Acetate 128-131 transferrin Homo sapiens 31-42 3934268-6 1985 Combination of the ionophore with PMA induced the occurrence of Tac and further increased the expression of transferrin receptor and HLA-DR. A23187 similarly enhanced the PMA-mediated increase in cell size. Tetradecanoylphorbol Acetate 34-37 transferrin Homo sapiens 108-119 3015429-1 1986 The treatment of human leukemia K562 cells with 12-0-tetradecanoyl phorbol-13-acetate (TPA) caused a decrease of transferrin receptors. Tetradecanoylphorbol Acetate 87-90 transferrin Homo sapiens 113-124 3015429-3 1986 In cells incubated with TPA, the rate of biosynthesis of transferrin receptors was reduced to 10-20% of that in untreated cells. Tetradecanoylphorbol Acetate 24-27 transferrin Homo sapiens 57-68 3015429-5 1986 These results indicated that the decrease of transferrin receptors in TPA-treated cells was caused by reduced biosynthesis and accelerated degradation of the receptors. Tetradecanoylphorbol Acetate 70-73 transferrin Homo sapiens 45-56 3005248-10 1985 These results indicated that TPA treatment of mitogen-activated human lymphocytes stimulated the phosphorylation of transferrin receptors, but TPA had no effect on the expression of the receptors thereafter. Tetradecanoylphorbol Acetate 29-32 transferrin Homo sapiens 116-127 3934268-6 1985 Combination of the ionophore with PMA induced the occurrence of Tac and further increased the expression of transferrin receptor and HLA-DR. A23187 similarly enhanced the PMA-mediated increase in cell size. Tetradecanoylphorbol Acetate 171-174 transferrin Homo sapiens 108-119 2988800-1 1985 When human erythroleukemia cells (K562) were exposed to phorbol-12-myristate 13-acetate (PMA), phosphorylation of transferrin receptors was enhanced 5-fold with 10(-7) M PMA and 7-fold with 10(-6) M PMA, but not with 4 alpha-phorbol (5 X 10(-7) M). Tetradecanoylphorbol Acetate 56-87 transferrin Homo sapiens 114-125 2992482-6 1985 Additionally, TPA and TCD both induced a high density of cell surface receptors for interleukin 2 (IL2) and transferrin, but not synthesis or production of IL2. Tetradecanoylphorbol Acetate 14-17 transferrin Homo sapiens 108-119 2988800-1 1985 When human erythroleukemia cells (K562) were exposed to phorbol-12-myristate 13-acetate (PMA), phosphorylation of transferrin receptors was enhanced 5-fold with 10(-7) M PMA and 7-fold with 10(-6) M PMA, but not with 4 alpha-phorbol (5 X 10(-7) M). Tetradecanoylphorbol Acetate 89-92 transferrin Homo sapiens 114-125 2988800-1 1985 When human erythroleukemia cells (K562) were exposed to phorbol-12-myristate 13-acetate (PMA), phosphorylation of transferrin receptors was enhanced 5-fold with 10(-7) M PMA and 7-fold with 10(-6) M PMA, but not with 4 alpha-phorbol (5 X 10(-7) M). Tetradecanoylphorbol Acetate 170-173 transferrin Homo sapiens 114-125 2988800-1 1985 When human erythroleukemia cells (K562) were exposed to phorbol-12-myristate 13-acetate (PMA), phosphorylation of transferrin receptors was enhanced 5-fold with 10(-7) M PMA and 7-fold with 10(-6) M PMA, but not with 4 alpha-phorbol (5 X 10(-7) M). Tetradecanoylphorbol Acetate 170-173 transferrin Homo sapiens 114-125 2580014-4 1985 Phorbol myristate acetate (PMA)-activated human T and small resting B cells and enhanced the expression of HLA-DR, HLA-DC/DS, and transferrin receptors while reducing Leu-4 antigen expression by T cells and IgM and IgD expression on B cells. Tetradecanoylphorbol Acetate 0-25 transferrin Homo sapiens 130-141 2580014-4 1985 Phorbol myristate acetate (PMA)-activated human T and small resting B cells and enhanced the expression of HLA-DR, HLA-DC/DS, and transferrin receptors while reducing Leu-4 antigen expression by T cells and IgM and IgD expression on B cells. Tetradecanoylphorbol Acetate 27-30 transferrin Homo sapiens 130-141 6088899-2 1984 Exposure of these cells to 12-0-tetradecanoyl phorbol-13-acetate (TPA) at 37 degrees C results in a 40% reduction of the specific binding of 125I-transferrin, which is apparent within 15 min. Tetradecanoylphorbol Acetate 66-69 transferrin Homo sapiens 146-157 6088899-5 1984 TPA reduces the number of transferrin receptors, and does not alter the degradation or the internalization of transferrin. Tetradecanoylphorbol Acetate 0-3 transferrin Homo sapiens 26-37 6961843-4 1982 TPA treatment of HL60 cells causes the rapid disappearance of the transferrin receptor from the cell surface. Tetradecanoylphorbol Acetate 0-3 transferrin Homo sapiens 66-77 7059675-4 1982 Binding of both L5.1 and transferrin to the surface of K562(S) cells is inhibited by treatment with 12--O-tetradecanoyl-phorbol-13-acetate, and the extent and time course of inhibition is similar in both cases. Tetradecanoylphorbol Acetate 100-138 transferrin Homo sapiens 25-36 9013617-3 1997 Ii chains visualized with luminal and cytoplasmic directed antibodies appeared in early endosomal compartments accessible to transferrin in response to phorbol 12-myristate 13-acetate treatment, whereas transmembrane Ii degradation products equivalent to the p12 Ii fragments were colocalized with the B cell receptors internalized after cross-linking. Tetradecanoylphorbol Acetate 152-183 transferrin Homo sapiens 125-136 6091866-4 1984 This effect of TPA was dependent upon an inhibition of the transferrin-binding capacity as estimated on intact cells. Tetradecanoylphorbol Acetate 15-18 transferrin Homo sapiens 59-70 6091866-5 1984 However, experiments with transferrin binding on cell samples dissolved in 1% Triton X-100 showed that TPA-treated cells exhibited a transferrin-binding capacity similar to that of control cells. Tetradecanoylphorbol Acetate 103-106 transferrin Homo sapiens 26-37 6091866-5 1984 However, experiments with transferrin binding on cell samples dissolved in 1% Triton X-100 showed that TPA-treated cells exhibited a transferrin-binding capacity similar to that of control cells. Tetradecanoylphorbol Acetate 103-106 transferrin Homo sapiens 133-144 6091866-6 1984 On the basis of this result, it is suggested that TPA modified a part of transferrin receptors present in the cells; as a result of this modification, these receptors became unavailable for binding transferrin, but they remained physically present in the cell. Tetradecanoylphorbol Acetate 50-53 transferrin Homo sapiens 73-84 6091866-6 1984 On the basis of this result, it is suggested that TPA modified a part of transferrin receptors present in the cells; as a result of this modification, these receptors became unavailable for binding transferrin, but they remained physically present in the cell. Tetradecanoylphorbol Acetate 50-53 transferrin Homo sapiens 198-209 6091866-10 1984 However, in spite of this marked stimulation of cell proliferation, TPA-stimulated lymphocytes exhibited a transferrin-binding capacity much inferior to cells stimulated by other mitogens, such as phytohemagglutinin. Tetradecanoylphorbol Acetate 68-71 transferrin Homo sapiens 107-118 6328486-1 1984 Treatment of human K562 cells with 4 beta-phorbol 12-myristate 13-acetate (PMA) resulted in an approximately 50% reduction in cell surface transferrin receptors within 30-45 min as judged by binding of both ligand and anti-receptor antibody. Tetradecanoylphorbol Acetate 35-73 transferrin Homo sapiens 139-150 6328486-1 1984 Treatment of human K562 cells with 4 beta-phorbol 12-myristate 13-acetate (PMA) resulted in an approximately 50% reduction in cell surface transferrin receptors within 30-45 min as judged by binding of both ligand and anti-receptor antibody. Tetradecanoylphorbol Acetate 75-78 transferrin Homo sapiens 139-150 6328486-4 1984 The kinetic parameters for the binding, internalization, intracellular residency, and recycling of 125I-labeled transferrin were unchanged by PMA treatment, as were the rate and extent of internalization of anti-receptor antibody. Tetradecanoylphorbol Acetate 142-145 transferrin Homo sapiens 112-123 8557777-10 1996 In Ca(2+)- or PMA-stimulated cells, FITC-dextran was delivered to endosomes that had been labeled with TRITC-transferrin. Tetradecanoylphorbol Acetate 14-17 transferrin Homo sapiens 109-120