PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11044097-6 2000 Consistent with this observation, using nuclear extracts prepared from Jurkat T cells, we show that HMG I (but not HMG Y) is strongly induced upon phorbol myristate acetate stimulation and this induced HMG I appears to both selectively inhibit the binding of basal DNA-binding proteins and enhance the binding of an inducible AP-1 transcription factor to this AP-1 binding site. Tetradecanoylphorbol Acetate 147-172 high mobility group AT-hook 1 Homo sapiens 100-105 24062859-8 2013 Finally, HMGA1 binding affinity to DNA was found to be influenced by the DNA A:T segment sequence context, with higher specificity be observed in HMGA1 binding to TnAn segments, which have two local minor groove minima on either side of the TpA step, compared to An:Tn segments, which have a single minor groove minimum at the 3" end of the An run, implying AT-hook binding favors narrow minor groove structure. Tetradecanoylphorbol Acetate 241-244 high mobility group AT-hook 1 Homo sapiens 9-14 24062859-8 2013 Finally, HMGA1 binding affinity to DNA was found to be influenced by the DNA A:T segment sequence context, with higher specificity be observed in HMGA1 binding to TnAn segments, which have two local minor groove minima on either side of the TpA step, compared to An:Tn segments, which have a single minor groove minimum at the 3" end of the An run, implying AT-hook binding favors narrow minor groove structure. Tetradecanoylphorbol Acetate 241-244 high mobility group AT-hook 1 Homo sapiens 146-151 15064752-8 2004 One of the identified genes, the high-mobility group protein A1 (Hmga1) is induced by TPA in P+, but not in transformation-resistant P cells. Tetradecanoylphorbol Acetate 86-89 high mobility group AT-hook 1 Homo sapiens 33-63 15064752-8 2004 One of the identified genes, the high-mobility group protein A1 (Hmga1) is induced by TPA in P+, but not in transformation-resistant P cells. Tetradecanoylphorbol Acetate 86-89 high mobility group AT-hook 1 Homo sapiens 65-70 15064752-9 2004 We show that TPA induction of the architectural transcription factor HMGA1 is inhibited by TAM67, is extracellular-signal-regulated kinase (ERK)-activation dependent, and is mediated by AP-1. Tetradecanoylphorbol Acetate 13-16 high mobility group AT-hook 1 Homo sapiens 69-74 15064752-10 2004 HMGA1 antisense construct transfected into P+ cells blocked HMGA1 protein expression and inhibited TPA-induced transformation indicating that HMGA1 is required for transformation. Tetradecanoylphorbol Acetate 99-102 high mobility group AT-hook 1 Homo sapiens 0-5 9692546-4 1998 HMG-I(Y) mRNAs were induced to higher levels by the tumor promoter 12-O-tetradecanoylphorbol acetate (TPA) and were sustained longer in P+ than in P- cells. Tetradecanoylphorbol Acetate 67-100 high mobility group AT-hook 1 Homo sapiens 0-8 9692546-4 1998 HMG-I(Y) mRNAs were induced to higher levels by the tumor promoter 12-O-tetradecanoylphorbol acetate (TPA) and were sustained longer in P+ than in P- cells. Tetradecanoylphorbol Acetate 102-105 high mobility group AT-hook 1 Homo sapiens 0-8 7775485-1 1995 Selective 12-O-tetradecanoylphorbol-13-acetate induction of a single transcription start site in the HMG-I/Y gene. Tetradecanoylphorbol Acetate 10-46 high mobility group AT-hook 1 Homo sapiens 101-108 7775485-2 1995 The human HMG-I/Y gene, encoding the non-histone "high mobility group" proteins HMG-I and HMG-Y, is transcriptionally activated in human K562 erythroleukemia cells by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 182-218 high mobility group AT-hook 1 Homo sapiens 10-17 7775485-2 1995 The human HMG-I/Y gene, encoding the non-histone "high mobility group" proteins HMG-I and HMG-Y, is transcriptionally activated in human K562 erythroleukemia cells by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA). Tetradecanoylphorbol Acetate 220-223 high mobility group AT-hook 1 Homo sapiens 10-17 7775485-4 1995 In this report, we show that transcriptional activation of the HMG-I/Y gene is dependent on protein synthesis and is an early event (2 h after induction) in the TPA-mediated differentiation process. Tetradecanoylphorbol Acetate 161-164 high mobility group AT-hook 1 Homo sapiens 63-70