PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12628440-4	2003	Treatment of CHO-IR cells with a cell-permeable calcium chelator, BAPTA-AM, abolished the insulin-induced activation of SGK1.	CAV protocol	13-16	insulin	Cricetulus griseus	90-97	
8617284-3	1996	Exposure of CHO.T cells to insulin, phorbol ester or serum resulted in a rapid increase (up to twofold) in eIF-4E phosphorylation.	CAV protocol	12-15	insulin	Cricetulus griseus	27-34	
9632753-7	1998	Insulin activation of p70 S6 kinase was inhibited by approximately 75% in CHO cells and approximately 30% in 3T3-L1 adipocytes, whereas insulin-induced activation of endogenous Akt was inhibited by 80 to 95%, by expression of Akt-AA.	CAV protocol	74-77	insulin	Cricetulus griseus	0-7	
9632753-9	1998	However, insulin-stimulated glucose uptake in both CHO cells and 3T3-L1 adipocytes was not affected by overexpression of Akt-AA, suggesting that Akt is not required for this effect of insulin.	CAV protocol	51-54	insulin	Cricetulus griseus	9-16	
12556481-2	2003	In this study, we show that SKIP inhibits phosphoinositide 3-kinase signaling in insulin-stimulated CHO cells.	CAV protocol	100-103	insulin	Cricetulus griseus	81-88	
8943212-6	1996	Co-transfection of CHO.T cells with dominant-negative mitogen-activated protein (MAP) kinase-kinase (MKK1) abrogated both insulin- and TZD-mediated activation of PPARgamma; transactivation was markedly increased in cells co-transfected with constitutively active MKK1.	CAV protocol	19-22	insulin	Cricetulus griseus	122-138	
8039498-6	1994	After insulin treatment of CHO-IR cells, anti-dynamin antibodies co-immunoprecipitated the IR beta-subunit and IRS-1, as tyrosine-phosphorylated proteins and PI 3-kinase activity.	CAV protocol	27-30	insulin	Cricetulus griseus	6-13	
7929278-4	1994	In contrast, treatment of CHO.T cells with the compounds resulted in significant increases in insulin-stimulated phosphatidylinositol (PI) 3-kinase activity.	CAV protocol	26-29	insulin	Cricetulus griseus	94-101	
3305910-6	1987	In these cells half maximum stimulation of glucose uptake occurs at 5 X 10(-10)M insulin, whereas normal CHO cells require 5 X 10(-12)M insulin.	CAV protocol	105-108	insulin	Cricetulus griseus	136-143	
8003510-8	1994	Insulin (1 microM) and FCS (9%) stimulate [3H]thymidine incorporation in parental CHO cells to a similar high level whereas in insulin receptor overexpressing CHO cells the maximum of insulin-stimulated [3H]thymidine incorporation is only 55% of the level reached by 9% FCS.	CAV protocol	82-85	insulin	Cricetulus griseus	0-7	
8003510-8	1994	Insulin (1 microM) and FCS (9%) stimulate [3H]thymidine incorporation in parental CHO cells to a similar high level whereas in insulin receptor overexpressing CHO cells the maximum of insulin-stimulated [3H]thymidine incorporation is only 55% of the level reached by 9% FCS.	CAV protocol	159-162	insulin	Cricetulus griseus	0-7	
8003510-8	1994	Insulin (1 microM) and FCS (9%) stimulate [3H]thymidine incorporation in parental CHO cells to a similar high level whereas in insulin receptor overexpressing CHO cells the maximum of insulin-stimulated [3H]thymidine incorporation is only 55% of the level reached by 9% FCS.	CAV protocol	159-162	insulin	Cricetulus griseus	127-134	
8266574-0	1993	[Synergism in the stimulating effect of transforming growth factor beta and insulin on the substrate-independent proliferation of the CHO-719 cell line].	CAV protocol	134-137	insulin	Cricetulus griseus	76-83	
1329727-2	1992	(1) Insulin treatment of CHO cells over-expressing wild-type insulin receptors resulted in the rapid and substantial (5-10-fold) activation of cytosolic protein kinases which phosphorylated myelin basic protein, Kemptide and two peptide substrates based on sites phosphorylated on ribosomal protein S6 in vivo.	CAV protocol	25-28	insulin	Cricetulus griseus	61-68	
7765921-0	1994	Extracellular insulin degrading activity creates instability in a CHO-based batch-refeed continuous process.	CAV protocol	66-69	insulin	Cricetulus griseus	14-21	
1647198-0	1991	Cytoplasmic juxtamembrane region of the insulin receptor: a critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells.	CAV protocol	165-168	insulin	Cricetulus griseus	40-47	
2154747-4	1990	Here we report that PI 3-kinase activity is immunoprecipitated from insulin-stimulated CHO cells by antiphosphotyrosine and anti-insulin receptor antibodies.	CAV protocol	87-90	insulin	Cricetulus griseus	68-75