PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32067950-1 2020 BACKGROUND AND PURPOSE: N,N-dimethyltryptamine (DMT) is an endogenous ligand of the Sigma 1 receptor (Sig-1R) with documented in vitro cytoprotective properties against hypoxia. N,N-Dimethyltryptamine 24-46 sigma non-opioid intracellular receptor 1 Rattus norvegicus 84-100 32067950-1 2020 BACKGROUND AND PURPOSE: N,N-dimethyltryptamine (DMT) is an endogenous ligand of the Sigma 1 receptor (Sig-1R) with documented in vitro cytoprotective properties against hypoxia. N,N-Dimethyltryptamine 24-46 sigma non-opioid intracellular receptor 1 Rattus norvegicus 102-108 32067950-1 2020 BACKGROUND AND PURPOSE: N,N-dimethyltryptamine (DMT) is an endogenous ligand of the Sigma 1 receptor (Sig-1R) with documented in vitro cytoprotective properties against hypoxia. N,N-Dimethyltryptamine 48-51 sigma non-opioid intracellular receptor 1 Rattus norvegicus 84-100 32067950-1 2020 BACKGROUND AND PURPOSE: N,N-dimethyltryptamine (DMT) is an endogenous ligand of the Sigma 1 receptor (Sig-1R) with documented in vitro cytoprotective properties against hypoxia. N,N-Dimethyltryptamine 48-51 sigma non-opioid intracellular receptor 1 Rattus norvegicus 102-108 32067950-13 2020 Sig-1R was expressed both in neurons and in microglia in the peri-infarct cortex, and the DMT induced change in the lesion volume was hindered by BD1063. N,N-Dimethyltryptamine 90-93 sigma non-opioid intracellular receptor 1 Rattus norvegicus 0-6 32067950-15 2020 CONCLUSION: Our results indicate a Sig-1R dependent reduction of the ischemic brain injury following exogenous DMT administration in rats, presumably through a combined anti-apoptotic, pro-neurotrophic and anti-inflammatory treatment effect. N,N-Dimethyltryptamine 111-114 sigma non-opioid intracellular receptor 1 Rattus norvegicus 35-41 34023338-0 2021 N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain. N,N-Dimethyltryptamine 0-22 sigma non-opioid intracellular receptor 1 Rattus norvegicus 94-110