PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16268908-0 2005 The effects of erythromycin on the viability and the secretion of TNF-alpha and TGF-beta1 and expression of connexin43 by human pleural mesothelial cells. Erythromycin 15-27 tumor necrosis factor Homo sapiens 66-75 23800068-7 2013 Suppression of TNFalpha signalling by tetracyclines, erythromycin and other macrolides may attenuate IKKbeta-TSC1-mediated mTORC1 activation. Erythromycin 53-65 tumor necrosis factor Homo sapiens 15-23 19318426-6 2009 On the contrary, Ucn II mRNA was increased by TNF-alpha alone and Ang II with tempol, and the TNF-alpha-induced increase in Ucn II mRNA was abolished by erythromycin and PDTC. Erythromycin 153-165 tumor necrosis factor Homo sapiens 94-103 31342602-5 2019 Furthermore, a significantly lower TNF-alpha response (P < 0 05) was observed in U937 cells challenged with GBS when erythromycin and nisin were used in combination. Erythromycin 117-129 tumor necrosis factor Homo sapiens 35-44 25769240-9 2015 EM900, CAM, or erythromycin significantly inhibited MUC5AC secretion induced by tumor necrosis factor-alpha from NCI-H292 cells. Erythromycin 15-27 tumor necrosis factor Homo sapiens 80-107 24852442-7 2013 However, erythromycin suppressed only the upregulation of TLR2 and TNFA. Erythromycin 9-21 tumor necrosis factor Homo sapiens 67-71 19500694-0 2009 In vitro effects of erythromycin on RANKL and nuclear factor-kappa B by human TNF-alpha stimulated Jurkat cells. Erythromycin 20-32 tumor necrosis factor Homo sapiens 78-87 16268908-7 2005 The secretion of both TNF-alpha and TGF-beta(1) by HMPC increased significantly when they were incubated with 100 mg/L erythromycin for 3 or 5 days. Erythromycin 119-131 tumor necrosis factor Homo sapiens 22-31 16268908-9 2005 CONCLUSIONS: Erythromycin injures HPMC in a dose- and time-dependent manner and results in the secretion of TNF-alpha and TGF-beta(1). Erythromycin 13-25 tumor necrosis factor Homo sapiens 108-117 14551160-7 2004 On the other hand, pretreatment of TNF-alpha-stimulated A549 cells by erythromycin, clarithromycin, azithromycin, or dexamethasone, but not josamycin, decreased the neutrophil survival-enhancing effects in a dose-dependent manner. Erythromycin 70-82 tumor necrosis factor Homo sapiens 35-44 14551160-9 2004 Erythromycin, clarithromycin, azithromycin, and dexamethasone inhibited TNF-alpha-induced GM-CSF expression in A549 cells at both the protein and messenger RNA levels. Erythromycin 0-12 tumor necrosis factor Homo sapiens 72-81 12901826-0 2003 [The effects of erythromycin on the secretion of tumor necrosis factor-alpha and transforming growth factor-beta1 and expression of connexin 43 in human pleural mesothelial cells]. Erythromycin 16-28 tumor necrosis factor Homo sapiens 49-76 12901826-1 2003 OBJECTIVES: To investigate the effects of erythromycin on secretion of tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta(1) (TGF-beta(1)), and the level of connexin 43 in human pleural mesothelial cells (HPMC), and to explore the mechanism of pleurodesis. Erythromycin 42-54 tumor necrosis factor Homo sapiens 71-98 12901826-1 2003 OBJECTIVES: To investigate the effects of erythromycin on secretion of tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta(1) (TGF-beta(1)), and the level of connexin 43 in human pleural mesothelial cells (HPMC), and to explore the mechanism of pleurodesis. Erythromycin 42-54 tumor necrosis factor Homo sapiens 100-109 12901826-4 2003 RESULTS: The secretion of TNF-alpha by HMPC increased after incubation with 100 mg/L erythromycin for 3 or 5 days, and the secretion of TGF-beta(1) increased markedly after incubation with lower or higher concentrations of erythromycin. Erythromycin 85-97 tumor necrosis factor Homo sapiens 26-35 12901826-6 2003 CONCLUSIONS: HPMC incubated with erythromycin showed increased secretion of TNF-alpha and TGF-beta(1), which may be one of the mechanisms for erythromycin pleurodesis. Erythromycin 33-45 tumor necrosis factor Homo sapiens 76-85 12901826-6 2003 CONCLUSIONS: HPMC incubated with erythromycin showed increased secretion of TNF-alpha and TGF-beta(1), which may be one of the mechanisms for erythromycin pleurodesis. Erythromycin 142-154 tumor necrosis factor Homo sapiens 76-85 1759822-3 1991 We compared the in vitro effects of three macrolides (roxithromycin, spiramycin, and erythromycin) actively concentrated by leukocytes on interleukin-1 alpha, (IL-1 alpha), IL-1 beta, IL-6, and tumor necrosis factor alpha production by human monocytes stimulated with lipopolysaccharide. Erythromycin 85-97 tumor necrosis factor Homo sapiens 194-221 12829454-5 2003 CAM and erythromycin significantly inhibited spontaneous and tumor necrosis factor-alpha (20 ng/ml)-induced mucus secretion from NCI-H292 cells at 10-6 to 10-7 M and from human nasal epithelial cells at 10-4 to 10-5 M. MUC5AC messenger RNA expression was also significantly inhibited. Erythromycin 8-20 tumor necrosis factor Homo sapiens 61-88 1416647-0 1992 Erythromycin inhibition of lipopolysaccharide-stimulated tumor necrosis factor alpha production by human monocytes in vitro. Erythromycin 0-12 tumor necrosis factor Homo sapiens 57-84 1416647-1 1992 The mechanism of clinical effectiveness of low-dose and long-term erythromycin (EM) treatment for diffuse panbronchiolitis, sinobronchial syndrome, and associated otitis media with effusion was investigated by studying the effects of EM on tumor necrosis factor alpha (TNF-alpha) production by cultured human monocytes stimulated with lipopolysaccharide. Erythromycin 66-78 tumor necrosis factor Homo sapiens 269-278