PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18212111-1	2008	The production of interleukin-8 induced by the activation of protease-activated receptor 2 and its synergism with interleukin-1beta were modulated by 14-membered-ring macrolides, namely, roxithromycin, erythromycin, and clarithromycin, in cultured normal human epidermal keratinocytes.	Erythromycin	202-214	interleukin 1 beta	Homo sapiens	114-131	
8608647-12	1996	Our results suggest that the relative amounts of IL-1beta and IL-1Ra or IL-8 may contribute, at least in part, to the neutrophil-mediated chronic airway inflammation in patients with chronic airway disease, and long-term erythromycin therapy may down-regulate the vigorous cycle between the cytokine network and neutrophil accumulation, with resultant reduction of neutrophil-mediated inflammatory response.	Erythromycin	221-233	interleukin 1 beta	Homo sapiens	49-57	
1759822-3	1991	We compared the in vitro effects of three macrolides (roxithromycin, spiramycin, and erythromycin) actively concentrated by leukocytes on interleukin-1 alpha, (IL-1 alpha), IL-1 beta, IL-6, and tumor necrosis factor alpha production by human monocytes stimulated with lipopolysaccharide.	Erythromycin	85-97	interleukin 1 beta	Homo sapiens	173-182	
30862504-3	2019	We report that in human primary articular chondrocytes, erythromycin, a well-known macrolide antibiotic, had the ability to inhibit pro-inflammatory cytokine Interleukin 1beta (IL-1beta)-induced catabolic gene expression and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activation.	Erythromycin	56-68	interleukin 1 beta	Homo sapiens	158-175