PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8608647-12 1996 Our results suggest that the relative amounts of IL-1beta and IL-1Ra or IL-8 may contribute, at least in part, to the neutrophil-mediated chronic airway inflammation in patients with chronic airway disease, and long-term erythromycin therapy may down-regulate the vigorous cycle between the cytokine network and neutrophil accumulation, with resultant reduction of neutrophil-mediated inflammatory response. Erythromycin 221-233 interleukin 1 beta Homo sapiens 49-57 18212111-1 2008 The production of interleukin-8 induced by the activation of protease-activated receptor 2 and its synergism with interleukin-1beta were modulated by 14-membered-ring macrolides, namely, roxithromycin, erythromycin, and clarithromycin, in cultured normal human epidermal keratinocytes. Erythromycin 202-214 interleukin 1 beta Homo sapiens 114-131 1759822-3 1991 We compared the in vitro effects of three macrolides (roxithromycin, spiramycin, and erythromycin) actively concentrated by leukocytes on interleukin-1 alpha, (IL-1 alpha), IL-1 beta, IL-6, and tumor necrosis factor alpha production by human monocytes stimulated with lipopolysaccharide. Erythromycin 85-97 interleukin 1 beta Homo sapiens 173-182 30862504-3 2019 We report that in human primary articular chondrocytes, erythromycin, a well-known macrolide antibiotic, had the ability to inhibit pro-inflammatory cytokine Interleukin 1beta (IL-1beta)-induced catabolic gene expression and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) activation. Erythromycin 56-68 interleukin 1 beta Homo sapiens 158-175