PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3606934-5 1987 The unbound fraction (fu) of erythromycin was significantly higher in cirrhotic patients (58.3 +/- 17.7%) than in normal subjects (30.5 +/- 2.8%, P less than 0.01), and a negative correlation was found between fu values and serum AAG (r = -0.867, P less than 0.01). Erythromycin 29-41 N-methylpurine DNA glycosylase Homo sapiens 230-233 3606934-9 1987 It is concluded that in cirrhotic patients, low serum AAG levels and reduced liver metabolic capacity may lead to marked changes in pharmacokinetics of erythromycin, and that similar results might be expected for drugs which exhibit the same serum binding and pharmacokinetic behaviour as erythromycin. Erythromycin 152-164 N-methylpurine DNA glycosylase Homo sapiens 54-57 3606934-9 1987 It is concluded that in cirrhotic patients, low serum AAG levels and reduced liver metabolic capacity may lead to marked changes in pharmacokinetics of erythromycin, and that similar results might be expected for drugs which exhibit the same serum binding and pharmacokinetic behaviour as erythromycin. Erythromycin 289-301 N-methylpurine DNA glycosylase Homo sapiens 54-57