PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8780573-0	1996	Erythromycin inhibits rabbit pyloric smooth muscle through neuronal motilin receptors.	Erythromycin	0-12	promotilin	Oryctolagus cuniculus	68-75	
9416990-11	1997	The motilin receptor present in the ileum is different from that demonstrated in the rabbit intestine, because of a different rank order of motilin peptides in producing the contraction, low contracting activity of erythromycin derivatives and low antagonistic efficacy of GM109.	Erythromycin	215-227	promotilin	Oryctolagus cuniculus	4-11	
9176206-6	1997	Erythromycin A and its derivative N-trimethyl erythromycin A cnol ether also bound to cerebellar motilin receptors (pKd,hi = 7.29 and 8.91, respectively).	Erythromycin	0-14	promotilin	Oryctolagus cuniculus	97-104	
10764957-6	2000	Motilin binding to these membranes was determined by the displacement of (125)I MOT by the native peptide MOT 1-22, or by peptide analogues MOT 1-12 [CH(2)NH](10-11) or GM-109 and by erythromycin derivative GM-611.	Erythromycin	183-195	promotilin	Oryctolagus cuniculus	0-7	
8780573-8	1996	Motilin tachyphylaxis both in the presence or absence of tetrodotoxin abolished the effects of erythromycin.	Erythromycin	95-107	promotilin	Oryctolagus cuniculus	0-7	
8780573-10	1996	CONCLUSIONS: These studies suggest that motilin receptors are present on both pyloric muscle and inhibitory neurons to pyloric muscle, that the primary effect of erythromycin on the pylorus is mediated by activating motilin receptors on inhibitory motor neurons, and that both nitric oxide and vasoactive intestinal peptide may mediate the inhibitory effect of erythromycin.	Erythromycin	162-174	promotilin	Oryctolagus cuniculus	40-47	
8780573-10	1996	CONCLUSIONS: These studies suggest that motilin receptors are present on both pyloric muscle and inhibitory neurons to pyloric muscle, that the primary effect of erythromycin on the pylorus is mediated by activating motilin receptors on inhibitory motor neurons, and that both nitric oxide and vasoactive intestinal peptide may mediate the inhibitory effect of erythromycin.	Erythromycin	162-174	promotilin	Oryctolagus cuniculus	216-223	
8959762-3	1996	The binding of [125I]motilin to BL membrane was competitively inhibited by both unlabeled motilin and erythromycin.	Erythromycin	102-114	promotilin	Oryctolagus cuniculus	21-28	
8959762-4	1996	The IC50s were (2.1 +/- 0.4) 10(-8) M and (1.3 +/- 0.1) 10(-6) M for motilin and erythromycin, respectively, and the Ki were (6.83 +/- 1.3) 10(-9) M for motilin and (4.32 +/- 0.33) 10(-7) M for erythromycin.	Erythromycin	81-93	promotilin	Oryctolagus cuniculus	153-160	
8959762-4	1996	The IC50s were (2.1 +/- 0.4) 10(-8) M and (1.3 +/- 0.1) 10(-6) M for motilin and erythromycin, respectively, and the Ki were (6.83 +/- 1.3) 10(-9) M for motilin and (4.32 +/- 0.33) 10(-7) M for erythromycin.	Erythromycin	194-206	promotilin	Oryctolagus cuniculus	69-76	
8297350-1	1994	Studies on the physiological role of motilin, and more recently, on the relationship between motilin and erythromycin A, have been hampered by the lack of antagonists.	Erythromycin	105-119	promotilin	Oryctolagus cuniculus	93-100	
7995222-2	1994	A recently developed motilin antagonist confirms that motility effects of erythromycin are mediated by motilin receptors.	Erythromycin	74-86	promotilin	Oryctolagus cuniculus	21-28	
7995222-2	1994	A recently developed motilin antagonist confirms that motility effects of erythromycin are mediated by motilin receptors.	Erythromycin	74-86	promotilin	Oryctolagus cuniculus	103-110	
2379773-5	1990	The correlation between the maximum contractile response toward motilin and erythromycin was almost perfect (r2 = 0.82).	Erythromycin	76-88	promotilin	Oryctolagus cuniculus	64-71