PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27858342-6 2017 RESULTS: The statin models reasonably predicted the observed exposure change due to Organic Anion Transporting Polypeptide (OATP) 1B1 polymorphism or clinical DDIs with itraconazole, erythromycin, and gemfibrozil, while under-predicted the observed DDIs caused by rifampin and cyclosporine. Erythromycin 183-195 solute carrier organic anion transporter family member 1B1 Homo sapiens 84-133 22990751-0 2012 OATP1B1 polymorphism as a determinant of erythromycin disposition. Erythromycin 41-53 solute carrier organic anion transporter family member 1B1 Homo sapiens 0-7 22990751-3 2012 Using stably transfected Flp-In T-Rex293 cells, erythromycin was found to be a substrate for OATP1B1*1A (wild type) with a Michaelis-Menten constant of ~13 micromol/l, and that its transport was reduced by ~50% in cells expressing OATP1B1*5 (V174A). Erythromycin 48-60 solute carrier organic anion transporter family member 1B1 Homo sapiens 93-100 22990751-3 2012 Using stably transfected Flp-In T-Rex293 cells, erythromycin was found to be a substrate for OATP1B1*1A (wild type) with a Michaelis-Menten constant of ~13 micromol/l, and that its transport was reduced by ~50% in cells expressing OATP1B1*5 (V174A). Erythromycin 48-60 solute carrier organic anion transporter family member 1B1 Homo sapiens 231-238 22990751-5 2012 In line with these observations, in humans the c.521T>C variant in SLCO1B1 (rs4149056), encoding OATP1B1*5, was associated with a decline in erythromycin metabolism (P = 0.0072). Erythromycin 144-156 solute carrier organic anion transporter family member 1B1 Homo sapiens 70-77 22990751-5 2012 In line with these observations, in humans the c.521T>C variant in SLCO1B1 (rs4149056), encoding OATP1B1*5, was associated with a decline in erythromycin metabolism (P = 0.0072). Erythromycin 144-156 solute carrier organic anion transporter family member 1B1 Homo sapiens 100-107 22990751-6 2012 These results suggest that impairment of OATP1B1 function can alter erythromycin metabolism, independent of changes in CYP3A4 activity. Erythromycin 68-80 solute carrier organic anion transporter family member 1B1 Homo sapiens 41-48